GSR Gene
protein-coding GIFtS: 71
GCID: GC08M030535
|
|
glutathione reductase
| |
Aliases
for GSR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutathione Reductase1 2 | | Glutathione Reductase, Mitochondrial2 | | GR2 3 | | GLUR3 | | GRase2 3 | | GRD13 | | EC 1.8.1.73 8 | | EC 1.8.18 |
Export aliases for GSR gene to outside databasesPrevious GC identifers: GC08M030441 GC08M030989 GC08M030594 GC08M030593 GC08M030655 GC08M029081 |
Summaries
for GSR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GSR:
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is ahomodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathionedisulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this generesult in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encodingdifferent isoforms have been found. (provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: GSHR_HUMAN, P00390Function: Maintains high levels of reduced glutathione in the cytosol
Gene Wiki entry for GSR (Glutathione reductase)
|
Genomic Views
for GSR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GSR gene promoter:
c-Fos GR p53 AP-1 ATF-2 c-Jun GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GSR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.1 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p21.1GSR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M030535: view genomic region
(about GC identifiers)
Start:
|
30,535,583 bp from pter |
End:
|
30,585,443 bp from pter |
Size:
|
49,861 bases |
Orientation:
|
minus strand |
|
Proteins
for GSR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GSHR_HUMAN, P00390 (See
protein sequence)Recommended Name: Glutathione reductase, mitochondrial precursor Size: 522 amino acids; 56257 Da
Cofactor: Binds 1 FAD per subunit
Subunit: Homodimer; disulfide-linked
Subcellular location: Isoform Mitochondrial: Mitochondrion
Subcellular location: Isoform Cytoplasmic: Cytoplasm
Miscellaneous: The active site is a redox-active disulfide bond
Sequence caution: Sequence=AAP88037.1; Type=Erroneous initiation;
6/27 PDB 3D structures from  and Proteopedia  for GSR (see all 27):1ALG (3D)
1BWC (3D)
1DNC (3D)
1GRA (3D)
1GRB (3D)
1GRE (3D)
Secondary accessions: C8KIL8 C8KIL9 C8KIM0 D3DSV3 Q7Z5C9 Q9NP63Alternative splicing, Alternative initiation: 5 isoforms: P00390-1 P00390-2 P00390-3 P00390-4 P00390-5 (Expressed at very high levels in peripheral blood)Explore the universe of human proteins at neXtProt for GSR: NX_P00390
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P00390
4/11 DME Specific Peptides for GSR (P00390) (see all 11)
GSR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_000628.2 NP_001182031.1 NP_001182032.1 NP_001182033.1
ENSEMBL proteins: ENSP00000221130 ENSP00000431044 ENSP00000429247 ENSP00000430825 ENSP00000445516 ENSP00000444559 ENSP00000438845 ENSP00000390065 Reactome Protein details: P00390
Human Recombinant Protein Products for GSR:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
GSR for ontologies About GeneDecksing
GSR Antibody Products:
Assay Products for GSR: |
Protein
Domains /
Families
for GSR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GSR for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P00390ProtoNet protein and cluster: P00390 3 Blocks protein families: IPB001100 Pyridine nucleotide-disulphide oxidoreductase IPB001327 Pyridine nucleotide-disulphide oxidoreductase IPB013027 FAD-dependent pyridine nucleotide reductase signature
UniProtKB/Swiss-Prot: GSHR_HUMAN, P00390Domain: Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2bind FAD and NADPH, respectively. Domain 4 forms the interfaceSimilarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family |
Function
for GSR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: GSHR_HUMAN, P00390Function: Maintains high levels of reduced glutathione in the cytosolCatalytic activity: 2 glutathione + NADP(+) = glutathione disulfide + NADPH Genatlas biochemistry entry for GSR:glutathione reductase (NADPH) FAD dependent,maintaining glutathione in the reduced state
Enzyme Numbers (IUBMB): EC 1.8.1.71 2 EC 1.8.12
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004362 | glutathione-disulfide reductase activity |
TAS | -- | | GO:0009055 | electron carrier activity |
TAS | 947404 | | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
-- | -- | | GO:0042803 | protein homodimerization activity |
-- | -- | | GO:0043295 | glutathione binding |
-- | -- |
GSR for ontologies About GeneDecksing
Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Gsr):
GSR for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSR (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSR (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): GSR (NM_000637) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSR |
|
Pathways & Interactions
for GSR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glutathione metabolism | | | 2 | Synthesis and interconversion of nucleotide di- and triphosphates | | | 3 | Oxidative Stress Regulatory Pathway (Erythrocyte) | | | 4 | Oxidative Stress | | | 5 | Selenium Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for GSR
1  GeneGo (Thomson Reuters) Pathway for GSR
5/7  BioSystems Pathways for GSR (see all 7)
3 
Reactome Pathways for GSR
1  PharmGKB Pathway for GSR
1 
Kegg Pathway (Kegg details for GSR):
GSR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GSR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/75 Interacting proteins for GSR (P003902, 3 ENSP000002211304) via UniProtKB, MINT, STRING, and/or I2D (see all 75)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006749 | glutathione metabolic process |
IEA | -- | | GO:0007283 | spermatogenesis |
-- | -- | | GO:0015949 | nucleobase-containing small molecule interconversion |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- | | GO:0045454 | cell redox homeostasis |
IEA | -- |
GSR for ontologies About GeneDecksing
|
Drugs & Compounds
for GSR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GSR for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for GSR |
 Browse Tocris compounds for GSR
9 HMDB Compounds for GSR About this table
10/13 DrugBank Compounds for GSR (see all 13) About this table
10/149 Novoseek chemical compound relationships for GSR gene (see all 149) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gssg |
89.5 |
218 |
16410648 (4), 9005440 (3), 18839590 (3), 15720387 (3) (see all 99) |
| trypanothione |
87.6 |
85 |
1924337 (4), 2059620 (3), 8168518 (3), 1924336 (3) (see all 36) |
| superoxide |
87.5 |
620 |
9853803 (4), 9013263 (3), 10569399 (2), 14633623 (2) (see all 99) |
| glucose 6-phosphate |
84 |
171 |
18308427 (3), 1841426 (2), 7586028 (2), 8655605 (2) (see all 99) |
| malondialdehyde |
80.5 |
263 |
16094713 (3), 16989498 (3), 20187535 (3), 16970843 (3) (see all 99) |
| nadph |
79.1 |
144 |
9175718 (3), 18166048 (2), 18498919 (2), 19668867 (2) (see all 99) |
| gamma-glutamylcysteine |
78.6 |
42 |
1677568 (1), 1945285 (1), 9724699 (1), 11133045 (1) (see all 31) |
| o-ethylhydroxylamine |
73.6 |
1 |
10087986 (1) |
| bcnu |
73.5 |
69 |
9113101 (4), 15857610 (4), 1468685 (1), 8254030 (1) (see all 39) |
| no-dimethylhydroxylamine |
71.5 |
5 |
9137808 (1), 10087986 (1) |
Search CenterWatch for drugs/clinical trials and news about GSR / GSHR
|
Transcripts
for GSR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GSR gene (4 alternative transcripts): NM_000637.3 NM_001195102.1 NM_001195103.1 NM_001195104.1 Unigene Cluster for GSR: Glutathione reductase Hs.271510 [show with all ESTs]Unigene Representative Sequence: NM_0006378 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221130(uc003xih.2 uc022ato.1 uc022atp.1 uc022atq.1)
ENST00000523295 ENST00000520888 ENST00000521479 ENST00000546342 ENST00000541648
ENST00000537535 ENST00000414019
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSR (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSR (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): GSR (NM_000637) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSR |
Additional cDNA sequence: AB519179.1 AB519180.1 AB519181.1 AF228704.1 BC035691.1 BC069244.1 X15722.1 X54507.1 3 DOTS entries: DT.97780985 DT.100798243 DT.86839565 24/183 AceView cDNA sequences (see all 183): BQ224655 C13971 AF228704 BQ225447 NM_000637 BQ216251 BC069244 BQ056743 CA397018 BQ436355 T08637 BQ954745 AL542274 AA725383 AW449420 CR597200 BM976198 BM478858 AI130967 BQ015920 CR603039 CB528732 T16495 BX402221
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for GSR About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GSR
|
Expression
for GSR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GSR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTGCACT
About this image
See GSR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSR
SOURCE GeneReport for Unigene cluster: Hs.271510
SABiosciences Expression via Pathway-Focused PCR Arrays including GSR (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GSR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSR |
Orthologs
for GSR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GSR gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for GSR (if available)
TreeFam Gene Tree for GSR (if available) |
Paralogs
for GSR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GSR gene
- TXNRD32 TXNRD12 TXNRD22
5 SIMAP similar genes for GSR using alignment to 4 protein entries: GSHR_HUMAN (see all proteins):DLD TXNRD2 TXNRD1 DKFZp781E0833 TXNRD3
GSR for paralogs About GeneDecksing
|
Genomic Variants
for GSR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GSR (30535583 - 30585443 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GSR
1 CNV: 52509
Human Gene Mutation Database (HGMD): GSR
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSR |
|
Disorders
/ Diseases
for GSR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GSR for disorders About GeneDecksing
OMIM gene information: 138300
OMIM disorders: --
20/205  diseases for GSR (see all 205): About MalaCardshemolytic anemia due to glutathione reductase deficiency protein-energy malnutrition tick-borne encephalitis spinal cord injury
hermansky-pudlak syndrome mitral valve prolapse rasmussen encephalitis leber hereditary optic neuropathy
pyridoxine deficiency age related macular degeneration variegate porphyria beta thalassemia
paraneoplastic cerebellar degeneration amyotrophic lateral sclerosis arterial occlusive disease peripheral arterial occlusive disease
plasmodium falciparum malaria senile cataract myocardial infarction friedreich ataxia
1 disease from the University of Copenhagen DISEASES database for GSR:Werner syndrome 10/95 Novoseek disease relationships for GSR gene (see all 95) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| riboflavin deficiency |
73 |
5 |
11924113 (1), 1915204 (1), 1425515 (1), 16109485 (1) (see all 5) |
| pyridoxine deficiency |
51.8 |
1 |
10459067 (1) |
| leishmaniasis old world cutaneous |
48.3 |
1 |
9174360 (1) |
| cell damage |
43.6 |
7 |
20041424 (2), 11676988 (1), 17952420 (1), 17427263 (1) (see all 6) |
| hemolysis |
42.6 |
14 |
15521559 (2), 20181004 (2), 2195189 (1), 1795479 (1) (see all 9) |
| chagas disease |
35.6 |
2 |
10571254 (1) |
| rasmussen encephalitis |
34.8 |
1 |
9892506 (1) |
| trypanosomiasis african |
33.5 |
1 |
9174360 (1) |
| neurodegenerative diseases |
28.8 |
3 |
15834439 (1), 12678430 (1), 16684968 (1) |
| methemoglobinemia |
25.8 |
2 |
10790768 (1), 8303876 (1) |
Genatlas disease: GSR hemolytic crisis
Genetic Association Database (GAD): GSR
Human Genome Epidemiology (HuGE) Navigator: GSR (22 documents)
Export disorders for GSR gene to outside databases
|
Publications
for GSR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GSR gene, integrated from 9 sources (see all 1257):
(articles sorted by number of sources associating them with GSR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. (PubMed id 9174360)1, 2, 9 Stoll V.S.... Pai E.F. (1997)
- Enzyme inactivation through sulfhydryl oxidation by physiologic NO- carriers. (PubMed id 9546215)1, 2, 9 Becker K.... Karplus P.A. (1998)
- Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor. (PubMed id 8626496)1, 2, 9 Savvides S.N. and Karplus P.A. (1996)
- Expression of glutathione reductase splice variants in human tissues. (PubMed id 20628807)1, 2 Satoh N.... Hisatomi H. (2010)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural organization of the human glutathione reductase (GSR) gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence. (PubMed id 10708558)1, 2 Kelner M.J. and Montoya M.A. (2000)
- Cloning and sequencing of mammalian glutathione reductase cDNA. (PubMed id 2185014)1, 2 Tutic M.... Werner D. (1990)
- Refined structure of glutathione reductase at 1.54-A resolution. (PubMed id 3656429)1, 2 Karplus P.A. and Schulz G.E. (1987)
|
External Searches for GSR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GSR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GSR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GSR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for GSR | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for GSR | Genetics and Cytogenetics in Oncology and Haematology | | NIEHS-SNPs | http://egp.gs.washington.edu/data/gsr/ | | Wikipedia | http://en.wikipedia.org/wiki/Glutathione_reductase |
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About This Section
| Patent Information for GSR gene:
Search GeneIP for patents involving GSR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GSR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for GSR | | OriGene shRNA RFP for GSR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSR | | | OriGene Protein Over-expression Lysate for GSR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GSR | | OriGene 3'-UTR Clone for GSR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GSR | | OriGene Custom Protein Services for GSR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSR |
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| | | | Search Tocris compounds for GSR |
| |  |  |  |  | | | | | | Recombinant Protein for GSR |
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 | | | GSR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSR |
|  |  |  |  | | | | ThermoFisher Antibodies for GSR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSR |
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