Aliases for GSPT2 Gene
External Ids for GSPT2 Gene
Previous GeneCards Identifiers for GSPT2 Gene
This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
GeneCards Summary for GSPT2 Gene
GSPT2 (G1 To S Phase Transition 2) is a Protein Coding gene. Diseases associated with GSPT2 include Syndromic X-Linked Intellectual Disability. Among its related pathways are Gene Expression and mRNA surveillance pathway. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is GSPT1.
UniProtKB/Swiss-Prot for GSPT2 Gene
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.