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Aliases for GSPT2 Gene

Aliases for GSPT2 Gene

  • G1 To S Phase Transition 2 2 3
  • ERF3B 3 4 6
  • Eukaryotic Peptide Chain Release Factor Subunit 3b 3 4
  • GST2 3 6
  • Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3B 3
  • G1 To S Phase Transition Protein 2 Homolog 4

External Ids for GSPT2 Gene

Previous GeneCards Identifiers for GSPT2 Gene

  • GC05P114495
  • GC0XP049533
  • GC0XP050171
  • GC0XP050403
  • GC0XP051319
  • GC0XP051503
  • GC0XP048925

Summaries for GSPT2 Gene

Entrez Gene Summary for GSPT2 Gene

  • This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

GeneCards Summary for GSPT2 Gene

GSPT2 (G1 To S Phase Transition 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GSPT1.

UniProtKB/Swiss-Prot for GSPT2 Gene

  • Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Wiki entry for GSPT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSPT2 Gene

Genomics for GSPT2 Gene

Regulatory Elements for GSPT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GSPT2 Gene

Start:
51,743,385 bp from pter
End:
51,746,232 bp from pter
Size:
2,848 bases
Orientation:
Plus strand

Genomic View for GSPT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSPT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSPT2 Gene

Proteins for GSPT2 Gene

  • Protein details for GSPT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYD1-ERF3B_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
    Protein Accession:
    Q8IYD1
    Secondary Accessions:
    • Q9H909
    • Q9NVY0
    • Q9NY44

    Protein attributes for GSPT2 Gene

    Size:
    628 amino acids
    Molecular mass:
    68883 Da
    Quaternary structure:
    • Interacts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1.

    Three dimensional structures from OCA and Proteopedia for GSPT2 Gene

neXtProt entry for GSPT2 Gene

Proteomics data for GSPT2 Gene at MOPED

Post-translational modifications for GSPT2 Gene

  • Ubiquitination at Lys325 and Lys619
  • Modification sites at PhosphoSitePlus

Other Protein References for GSPT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GSPT2 Gene

Domains for GSPT2 Gene

Suggested Antigen Peptide Sequences for GSPT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYD1

UniProtKB/Swiss-Prot:

ERF3B_HUMAN :
  • Q8IYD1
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
genes like me logo Genes that share domains with GSPT2: view

No data available for Gene Families for GSPT2 Gene

Function for GSPT2 Gene

Molecular function for GSPT2 Gene

GENATLAS Biochemistry: peptide chain release factor 3b,interacting and stimulating ERF1,controlled stop-codon directed release
UniProtKB/Swiss-Prot Function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Ontology (GO) - Molecular Function for GSPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 14685257
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GSPT2: view

Phenotypes for GSPT2 Gene

GenomeRNAi human phenotypes for GSPT2:
genes like me logo Genes that share phenotypes with GSPT2: view

Animal Model Products

CRISPR Products

miRNA for GSPT2 Gene

miRTarBase miRNAs that target GSPT2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GSPT2 Gene

Localization for GSPT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSPT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSPT2 Gene COMPARTMENTS Subcellular localization image for GSPT2 gene
Compartment Confidence
cytosol 4
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GSPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GSPT2: view

Pathways for GSPT2 Gene

genes like me logo Genes that share pathways with GSPT2: view

Pathways by source for GSPT2 Gene

Gene Ontology (GO) - Biological Process for GSPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0006412 translation TAS --
GO:0006415 translational termination TAS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with GSPT2: view

Compounds for GSPT2 Gene

(1) HMDB Compounds for GSPT2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GSPT2: view

Transcripts for GSPT2 Gene

mRNA/cDNA for GSPT2 Gene

(69) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSPT2 Gene

G1 to S phase transition 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSPT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSPT2 Gene

No ASD Table

Relevant External Links for GSPT2 Gene

GeneLoc Exon Structure for
GSPT2
ECgene alternative splicing isoforms for
GSPT2

Expression for GSPT2 Gene

mRNA expression in normal human tissues for GSPT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSPT2 Gene

SOURCE GeneReport for Unigene cluster for GSPT2 Gene Hs.59523

mRNA Expression by UniProt/SwissProt for GSPT2 Gene

Q8IYD1-ERF3B_HUMAN
Tissue specificity: Highly expressed in IUCC stage II colorectal cancer (CRC).
genes like me logo Genes that share expressions with GSPT2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for GSPT2 Gene

Orthologs for GSPT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GSPT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSPT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSPT2 35
  • 92.37 (n)
  • 93.18 (a)
dog
(Canis familiaris)
Mammalia LOC480921 35
  • 92.03 (n)
  • 94.26 (a)
mouse
(Mus musculus)
Mammalia Gspt2 35
  • 88.22 (n)
  • 90.39 (a)
Gspt2 16
Gspt2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Gspt2 35
  • 89.07 (n)
  • 91.68 (a)
chicken
(Gallus gallus)
Aves GSPT1 36
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12290 35
zebrafish
(Danio rerio)
Actinopterygii gspt1 36
  • 79 (a)
ManyToMany
gspt1l 36
  • 77 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Elf 36
  • 56 (a)
OneToMany
Elf 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea erfa-3 35
  • 59.61 (n)
  • 59.54 (a)
erfa-3 36
  • 56 (a)
OneToMany
H19N07.1 37
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUP35 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9703 36
  • 65 (a)
OneToMany
Species with no ortholog for GSPT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSPT2 Gene

ENSEMBL:
Gene Tree for GSPT2 (if available)
TreeFam:
Gene Tree for GSPT2 (if available)

Paralogs for GSPT2 Gene

Paralogs for GSPT2 Gene

Selected SIMAP similar genes for GSPT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GSPT2: view

Variants for GSPT2 Gene

Sequence variations from dbSNP and Humsavar for GSPT2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs974285 -- 51,743,563(+) GCCGG(C/T)GGAGC utr-variant-5-prime
rs11796743 -- 51,743,099(+) AGTTA(A/C)CCCTT upstream-variant-2KB
rs17853537 -- 51,743,638(+) TCGGG(C/T)AGCAG reference, synonymous-codon
rs17855591 -- 51,744,687(+) TGATC(A/C)CACAG missense, reference
rs17855592 -- 51,745,500(+) GGTCC(A/C)AGAGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for GSPT2 Gene

Variant ID Type Subtype PubMed ID
nsv7444 OTHER Inversion 18451855

Relevant External Links for GSPT2 Gene

HapMap Linkage Disequilibrium report
GSPT2
Human Gene Mutation Database (HGMD)
GSPT2
Locus Specific Mutation Databases (LSDB)
GSPT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSPT2 Gene

Disorders for GSPT2 Gene

Relevant External Links for GSPT2

Genetic Association Database (GAD)
GSPT2
Human Genome Epidemiology (HuGE) Navigator
GSPT2
genes like me logo Genes that share disorders with GSPT2: view

No data available for UniProtKB/Swiss-Prot for GSPT2 Gene

Publications for GSPT2 Gene

  1. Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. (PMID: 15987998) Chauvin C. … Jean-Jean O. (Mol. Cell. Biol. 2005) 3 4 23
  2. Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23-->p11.21 and of the distal marker DXS1039 by radiation hybrid mapping. (PMID: 10575220) Hansen L.L. … Justesen J. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo. (PMID: 11524954) Jakobsen C.G. … Justesen J. (Mol. Biol. (Mosk.) 2001) 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. (PMID: 9712840) Hoshino S. … Katada T. (J. Biol. Chem. 1998) 3 23

Products for GSPT2 Gene

Sources for GSPT2 Gene

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