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GSPT2 Gene

protein-coding   GIFtS: 63
GCID: GC0XP051503

G1 To S Phase Transition 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G1 To S Phase Transition 21 2     Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3B2
ERF3B2 3 5     eRF3b3
Eukaryotic Peptide Chain Release Factor Subunit 3b2 3     G1 To S Phase Transition Protein 2 Homolog3
GST22 5     

External Ids:    HGNC: 46221   Entrez Gene: 237082   Ensembl: ENSG000001893697   OMIM: 3004185   UniProtKB: Q8IYD13   

Export aliases for GSPT2 gene to outside databases

Previous GC identifers: GC05P114495 GC0XP049533 GC0XP050171 GC0XP050403 GC0XP051319 GC0XP048925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSPT2 Gene:
This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a
polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation
termination. This protein may also be involved in mRNA stability.(provided by RefSeq, Mar 2010)

GeneCards Summary for GSPT2 Gene:
GSPT2 (G1 to S phase transition 2) is a protein-coding gene. Diseases associated with GSPT2 include tuberculosis, and colorectal cancer. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is HBS1L.

UniProtKB/Swiss-Prot: ERF3B_HUMAN, Q8IYD1
Function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a
role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome-
and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which
recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature
stop codons

Gene Wiki entry for GSPT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011630.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSPT2 gene promoter:
         SRF   C/EBPbeta   AML1a   SRF (504 AA)   COMP1   HTF   POU3F1   XBP-1   Pax-4a   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSPT2 promoter sequence
   Search Chromatin IP Primers for GSPT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSPT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

GSPT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSPT2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP051503:  view genomic region     (about GC identifiers)

Start:
51,486,481 bp from pter      End:
51,489,328 bp from pter
Size:
2,848 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ERF3B_HUMAN, Q8IYD1 (See protein sequence)
Recommended Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3B  
Size: 628 amino acids; 68883 Da
Subunit: Interacts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.
Interacts with UPF1 and PABPC1
1 PDB 3D structure from and Proteopedia for GSPT2:
3KUJ (3D)    
Secondary accessions: Q9H909 Q9NVY0 Q9NY44

Explore the universe of human proteins at neXtProt for GSPT2: NX_Q8IYD1

Explore proteomics data for GSPT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys325, Lys619
  • Modification sites at PhosphoSitePlus

  • See GSPT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060564.2  
    ENSEMBL proteins: 
     ENSP00000341247  
    Reactome Protein details: Q8IYD1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000795 EF_GTP-bd_dom
     IPR009818 Ataxin-2_C
     IPR004160 Transl_elong_EFTu/EF1A_C
     IPR004161 Transl_elong_EFTu/EF1A_2
     IPR009000 Transl_B-barrel

    Graphical View of Domain Structure for InterPro Entry Q8IYD1

    ProtoNet protein and cluster: Q8IYD1

    2 Blocks protein domains:
    IPB004160 Elongation factor Tu
    IPB009818 Ataxin-2


    UniProtKB/Swiss-Prot: ERF3B_HUMAN, Q8IYD1
    Similarity: Belongs to the GTP-binding elongation factor family. ERF3 subfamily


    GSPT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERF3B_HUMAN, Q8IYD1
    Function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a
    role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome-
    and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which
    recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature
    stop codons

         Genatlas biochemistry entry for GSPT2:
    peptide chain release factor 3b,interacting and stimulating ERF1,controlled stop-codon directed release

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI14685257
    GO:0005525GTP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    GSPT2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GSPT2:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSPT2
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    miRNA
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    miRTarBase miRNAs that target GSPT2:
    hsa-mir-26b-5p (MIRT029919)

    Block miRNA regulation of human, mouse, rat GSPT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GSPT2 (see all 22):
    hsa-miR-320a hsa-miR-607 hsa-miR-520d-5p hsa-miR-539 hsa-miR-4272 hsa-miR-128 hsa-miR-888* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidGSPT2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERF3B_HUMAN, Q8IYD1: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    GSPT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSPT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Eukaryotic Translation Termination0.93
    Translation0.82
    Nonsense-Mediated Decay0.89
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Translation Factors
    Translation Factors
    5mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for GSPT2
        Translation Factors

    3 Reactome Pathways for GSPT2
        Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Eukaryotic Translation Termination
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


    1 Kegg Pathway  (Kegg details for GSPT2):
        mRNA surveillance pathway


    GSPT2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GSPT2
    Interactions:

        GeneGlobe Interaction Network for GSPT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSPT2 (Q8IYD11, 3 ENSP000003412474) via UniProtKB, MINT, STRING, and/or I2D (see all 380)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206353Q154773, ENSP000003728274I2D: score=1 STRING: ENSP00000372827
    ENSG00000223493Q154773, ENSP000004123104I2D: score=1 STRING: ENSP00000412310
    ENSG00000225737Q154773, ENSP000003944004I2D: score=1 STRING: ENSP00000394400
    ENSG00000228896Q154773, ENSP000003995304I2D: score=1 STRING: ENSP00000399530
    ENSG00000232616Q154773, ENSP000004006264I2D: score=1 STRING: ENSP00000400626
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0006412translation TAS--
    GO:0006415translational termination TAS--
    GO:0007049cell cycle IEA--
    GO:0010467gene expression TAS--

    GSPT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GSPT2 (ERF3B)

    1 HMDB Compound for GSPT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GSPT2 gene: 
    NM_018094.4  

    Unigene Cluster for GSPT2:

    G1 to S phase transition 2
    Hs.59523  [show with all ESTs]
    Unigene Representative Sequence: NM_018094
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340438(uc004dpl.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GSPT2 (see all 22):
    hsa-miR-320a hsa-miR-607 hsa-miR-520d-5p hsa-miR-539 hsa-miR-4272 hsa-miR-128 hsa-miR-888* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidGSPT2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat GSPT2
      QuantiFast Probe-based Assays in human, mouse, rat GSPT2

    Additional mRNA sequence: 

    AJ251548.1 AK001303.1 AK023155.1 AK225671.1 AK298868.1 BC036077.1 

    5 DOTS entries:

    DT.99958236  DT.455628  DT.100744560  DT.95135422  DT.121323718 

    Selected AceView cDNA sequences (see all 69):

    BF514488 NM_018094 CA417922 W94438 AW511072 F08788 BG565067 AU118532 
    BE727713 R29231 CR623122 BU947673 F05297 AW173325 BE855507 AA805179 
    AJ251548 CB162313 AI249737 BC036077 AA341451 BU934635 AK023155 AA331334 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSPT2 expression in normal human tissues (normalized intensities)      GSPT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GSPT2 Expression
    About this image


    GSPT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    GSPT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSPT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59523

    UniProtKB/Swiss-Prot: ERF3B_HUMAN, Q8IYD1
    Tissue specificity: Highly expressed in IUCC stage II colorectal cancer (CRC)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GSPT2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gspt21 , 5 G1 to S phase transition 21, 5 88.22(n)1
    90.39(a)1
      X (41.63 cM)5
    148531  NM_008179.21  NP_032205.21 
     946360695 
    chicken
    (Gallus gallus)
    Aves GSPT16
    Gallus gallus G1 to S phase transition 1 (GSPT1), ...
    85(a)
    1 → many
    14(115569-141085)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL343580.1(1061-19401)
    zebrafish
    (Danio rerio)
    Actinopterygii gspt16
    gspt1l6
    G1 to S phase transition 1, like
    79(a)
    77(a)
    many ↔ many
    many ↔ many
    12(20458617-20480227) ENSDARG00000031048
    3(36526652-36544908) ENSDARG00000014123
    fruit fly
    (Drosophila melanogaster)
    Insecta Elf3 translational termination translation
    termination more
    73(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea H19N07.13
    erfa-31
    elongation factor3
    erfa-31
    58(a)3
    59.61(n)1
    59.54(a)1
      V(11113044-11115666)3
    1795371  NM_001269363.11  NP_001256292.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUP356
    Translation termination factor eRF3, has a role in...
    39(a)
    1 → many
    IV(808324-810381) YDR172W


    ENSEMBL Gene Tree for GSPT2 (if available)
    TreeFam Gene Tree for GSPT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSPT2 gene
    HBS1L2  GSPT12  
    5 SIMAP similar genes for GSPT2 using alignment to 1 protein entry:     ERF3B_HUMAN:
    GSPT1    HBS1L    EEF1A1    EEF1A1P5    EEF1A2

    GSPT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSPT2 (see all 69)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452921171,2
    --51496855(+) TTATGA/TCACTG 1 -- us2k10--------
    rs1893587741,2
    --51496877(+) TCCATA/GACCGG 1 -- us2k10--------
    rs1814022121,2
    --51496952(+) AAAACA/CTCAAG 1 -- us2k10--------
    rs772830021,2
    C--51497420(+) CAGATC/TGTTTG 1 -- us2k10--------
    rs1424652311,2
    --51498080(+) AACTAC/TAGAAG 1 -- us2k10--------
    rs1459547971,2
    --51498276(+) CTGTAG/TAGTTA 1 -- us2k10--------
    rs117967431,2
    C,F,H--51498282(+) AGTTAA/CCCCTT 1 -- us2k115Minor allele frequency- C:0.07NS EA NA 1982
    rs1864148301,2
    C--51498382(+) ATCATC/GAGATT 1 -- us2k10--------
    rs1889605081,2
    --51498464(+) TTTTGA/GACTTA 1 -- us2k10--------
    rs1814012071,2
    --51498596(+) CCGCTC/GACACA 1 -- ut510--------

    HapMap Linkage Disequilibrium report for GSPT2 (51486481 - 51489328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for GSPT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7444OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): GSPT2
    Locus Specific Mutation Databases (LSDB): GSPT2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300418    OMIM disorders: --

    4 diseases for GSPT2:    About MalaCards
    tuberculosis    colorectal cancer    prostate cancer    prostatitis


    GSPT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): GSPT2
    Human Genome Epidemiology (HuGE) Navigator: GSPT2 (1 document)

    Export disorders for GSPT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSPT2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with GSPT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. (PubMed id 15987998)1, 2, 9 Chauvin C....Jean-Jean O. (Mol. Cell. Biol. 2005)
    2. Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23--&gt;p11.21 and of the distal marker DXS1039 by radiation hybrid mapping. (PubMed id 10575220)1, 3, 9 Hansen L.L....Justesen J. (Cytogenet. Cell Genet. 1999)
    3. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. (PubMed id 18447585)1, 2 Singh G.... Lykke-Andersen J. (PLoS Biol. 2008)
    4. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PubMed id 18264098)1, 4 Gudmundsson J.... Stefansson K. (Nat. Genet. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo. (PubMed id 11524954)2, 9 Jakobsen C.G.... Justesen J. (Mol. Biol. (Mosk.) 2001)
    7. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. (PubMed id 9712840)1, 9 Hoshino S....Katada T. (J. Biol. Chem. 1998)
    8. Evolution of translation termination factor eRF3: is GSPT2 generated by retrotransposition of GSPT1's mRNA? (PubMed id 16754297)1, 9 Zhouravleva G....Inge-Vechtomov S. (IUBMB Life 2006)
    9. Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway. (PubMed id 17562865)2, 9 Chauvin C.... Jean-Jean O. (Mol. Cell. Biol. 2007)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23708 HGNC: 4622 AceView: GSPT2 Ensembl:ENSG00000189369 euGenes: HUgn23708
    ECgene: GSPT2 Kegg: 23708 H-InvDB: GSPT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GSPT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSPT2 gene:
    Search GeneIP for patents involving GSPT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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