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Aliases for GSPT2 Gene

Aliases for GSPT2 Gene

  • G1 To S Phase Transition 2 2 3 5
  • Eukaryotic Peptide Chain Release Factor Subunit 3b 3 4
  • ERF3B 3 4
  • Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3B 3
  • G1 To S Phase Transition Protein 2 Homolog 4
  • GST2 3

External Ids for GSPT2 Gene

Previous GeneCards Identifiers for GSPT2 Gene

  • GC05P114495
  • GC0XP049533
  • GC0XP050171
  • GC0XP050403
  • GC0XP051319
  • GC0XP051503
  • GC0XP048925

Summaries for GSPT2 Gene

Entrez Gene Summary for GSPT2 Gene

  • This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

GeneCards Summary for GSPT2 Gene

GSPT2 (G1 To S Phase Transition 2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and mRNA surveillance pathway. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is GSPT1.

UniProtKB/Swiss-Prot for GSPT2 Gene

  • Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Wiki entry for GSPT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSPT2 Gene

Genomics for GSPT2 Gene

Regulatory Elements for GSPT2 Gene

Enhancers for GSPT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF051742 0.7 ENCODE 0.8 0.0 -29 1.8 ETV1 ZBTB40 YY1 EGR1 POLR2A CBX5 PATZ1 SCRT2 ZSCAN29 EGR2 NUDT11 GSPT2 CENPVL1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GSPT2 on UCSC Golden Path with GeneCards custom track

Promoters for GSPT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071696 815 2800 RAD21 ZBTB40 YY1 CBX5 SCRT2 EGR2 ZNF680 ZNF654 CBFB REST

Genomic Location for GSPT2 Gene

Chromosome:
X
Start:
51,743,385 bp from pter
End:
51,746,232 bp from pter
Size:
2,848 bases
Orientation:
Plus strand

Genomic View for GSPT2 Gene

Genes around GSPT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSPT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSPT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSPT2 Gene

Proteins for GSPT2 Gene

  • Protein details for GSPT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYD1-ERF3B_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
    Protein Accession:
    Q8IYD1
    Secondary Accessions:
    • Q9H909
    • Q9NVY0
    • Q9NY44

    Protein attributes for GSPT2 Gene

    Size:
    628 amino acids
    Molecular mass:
    68883 Da
    Quaternary structure:
    • Interacts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1.

    Three dimensional structures from OCA and Proteopedia for GSPT2 Gene

neXtProt entry for GSPT2 Gene

Post-translational modifications for GSPT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSPT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSPT2 Gene

Domains & Families for GSPT2 Gene

Suggested Antigen Peptide Sequences for GSPT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYD1

UniProtKB/Swiss-Prot:

ERF3B_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
genes like me logo Genes that share domains with GSPT2: view

No data available for Gene Families for GSPT2 Gene

Function for GSPT2 Gene

Molecular function for GSPT2 Gene

GENATLAS Biochemistry:
peptide chain release factor 3b,interacting and stimulating ERF1,controlled stop-codon directed release
UniProtKB/Swiss-Prot Function:
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Ontology (GO) - Molecular Function for GSPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003747 translation release factor activity IBA --
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 9712840
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GSPT2: view
genes like me logo Genes that share phenotypes with GSPT2: view

Animal Model Products

miRNA for GSPT2 Gene

miRTarBase miRNAs that target GSPT2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSPT2 Gene

Localization for GSPT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSPT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSPT2 Gene COMPARTMENTS Subcellular localization image for GSPT2 gene
Compartment Confidence
cytosol 5
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GSPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0018444 translation release factor complex IBA --
genes like me logo Genes that share ontologies with GSPT2: view

Pathways & Interactions for GSPT2 Gene

genes like me logo Genes that share pathways with GSPT2: view

Gene Ontology (GO) - Biological Process for GSPT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002184 cytoplasmic translational termination IBA --
GO:0006412 translation IEA --
GO:0006415 translational termination TAS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with GSPT2: view

No data available for SIGNOR curated interactions for GSPT2 Gene

Drugs & Compounds for GSPT2 Gene

(1) Drugs for GSPT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GSPT2: view

Transcripts for GSPT2 Gene

mRNA/cDNA for GSPT2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(69) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSPT2 Gene

G1 to S phase transition 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSPT2 Gene

No ASD Table

Relevant External Links for GSPT2 Gene

GeneLoc Exon Structure for
GSPT2
ECgene alternative splicing isoforms for
GSPT2

Expression for GSPT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSPT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSPT2 Gene

This gene is overexpressed in Heart (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSPT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of GSPT2 Gene:

GSPT2

SOURCE GeneReport for Unigene cluster for GSPT2 Gene:

Hs.59523

mRNA Expression by UniProt/SwissProt for GSPT2 Gene:

Q8IYD1-ERF3B_HUMAN
Tissue specificity: Highly expressed in IUCC stage II colorectal cancer (CRC).
genes like me logo Genes that share expression patterns with GSPT2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for GSPT2 Gene

Orthologs for GSPT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GSPT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSPT2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia GSPT2 34
  • 92.37 (n)
dog
(Canis familiaris)
Mammalia LOC480921 34
  • 92.03 (n)
rat
(Rattus norvegicus)
Mammalia Gspt2 34
  • 89.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gspt2 34 16 35
  • 88.22 (n)
chicken
(Gallus gallus)
Aves GSPT1 35
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 89 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gspt1 35
  • 79 (a)
ManyToMany
gspt1l 35
  • 77 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12290 34
fruit fly
(Drosophila melanogaster)
Insecta Elf 36 35
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea erfa-3 34 35
  • 59.61 (n)
H19N07.1 36
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUP35 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9703 35
  • 65 (a)
OneToMany
Species where no ortholog for GSPT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSPT2 Gene

ENSEMBL:
Gene Tree for GSPT2 (if available)
TreeFam:
Gene Tree for GSPT2 (if available)

Paralogs for GSPT2 Gene

Paralogs for GSPT2 Gene

(5) SIMAP similar genes for GSPT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GSPT2: view

Variants for GSPT2 Gene

Sequence variations from dbSNP and Humsavar for GSPT2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs398124340 Uncertain significance 51,743,948(+) GGGGG(-/G)CACCT reference, frameshift-variant
rs797044501 Uncertain significance 51,744,784(+) ATTCA(C/T)TTTAT reference, synonymous-codon
rs111300482 -- 51,743,760(+) CCTCA(A/G)CTCGG reference, missense
rs111514646 -- 51,745,087(+) GCCCC(A/T)GGTGA reference, synonymous-codon
rs113213313 -- 51,746,479(+) TTATG(A/G)CATTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GSPT2 Gene

Variant ID Type Subtype PubMed ID
esv3350872 OTHER inversion 20981092
nsv7444 OTHER inversion 18451855

Variation tolerance for GSPT2 Gene

Residual Variation Intolerance Score: 6.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSPT2 Gene

Human Gene Mutation Database (HGMD)
GSPT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSPT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSPT2 Gene

Disorders for GSPT2 Gene

Relevant External Links for GSPT2

Genetic Association Database (GAD)
GSPT2
Human Genome Epidemiology (HuGE) Navigator
GSPT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSPT2

No disorders were found for GSPT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSPT2 Gene

Publications for GSPT2 Gene

  1. Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. (PMID: 15987998) Chauvin C. … Jean-Jean O. (Mol. Cell. Biol. 2005) 3 4 22 64
  2. Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23-->p11.21 and of the distal marker DXS1039 by radiation hybrid mapping. (PMID: 10575220) Hansen L.L. … Justesen J. (Cytogenet. Cell Genet. 1999) 2 3 22 64
  3. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PMID: 18264098) Gudmundsson J. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  4. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. (PMID: 18447585) Singh G. … Lykke-Andersen J. (PLoS Biol. 2008) 3 4 64
  5. Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway. (PMID: 17562865) Chauvin C. … Jean-Jean O. (Mol. Cell. Biol. 2007) 4 22 64

Products for GSPT2 Gene

Sources for GSPT2 Gene

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