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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSPT1 Gene

protein-coding   GIFtS: 62
GCID: GC16M011961

G1 to S phase transition 1

 Explore 7 diseases affiliated with
GSPT1 via our new
 Human Malady Compendium 
Biological research products
for GSPT1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
G1 To S Phase Transition 11 2     G1 To S Phase Transition Protein 1 Homolog2 3
ERF3a1     551G9.22
ETF3A1 2     Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A2
GST11 2     ERF3A3
Eukaryotic Peptide Chain Release Factor Subunit 3a2 3     

External Ids:    HGNC: 46211   Entrez Gene: 29352   Ensembl: ENSG000001033427   OMIM: 1392595   UniProtKB: P151703   

Export aliases for GSPT1 gene to outside databases

Previous GC identifers: GC16M011749 GC16M012118 GC16M011932 GC16M011874 GC16M011878


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170
Function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the
activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which
recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop
codons

Gene Wiki entry for GSPT1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSPT1 gene promoter:
         p53   XBP-1   IRF-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GSPT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSPT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.1   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.1

GSPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSPT1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M011961:  view genomic region     (about GC identifiers)

Start:
11,961,985 bp from pter      End:
12,010,519 bp from pter
Size:
48,535 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170 (See protein sequence)
Recommended Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A  
Size: 499 amino acids; 55756 Da
Subunit: Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex
Caution: eRF3 antibodies used in PubMed:19417104 do not differentiate between GSPT1/ERF3A and GSPT2/ERF3B
2 PDB 3D structures from and Proteopedia for GSPT1:
3E1Y (3D)        3KUI (3D)    
Secondary accessions: Q96GF2
Alternative splicing: 2 isoforms:  P15170-1   P15170-2   (Ref.3 (AAH09503) sequence is in conflict in position: 6-9:GGGG->G, 92:G->C, 100:V->A)

Explore the universe of human proteins at neXtProt for GSPT1: NX_P15170

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15170

  • GSPT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123478.1  NP_001123479.1  NP_002085.2  

    ENSEMBL proteins: 
     ENSP00000398131   ENSP00000408399   ENSP00000456057   ENSP00000454351   ENSP00000399539  
     ENSP00000456897   ENSP00000454538  

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    Uscn Proteins for GSPT1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS15326224


    GSPT1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GSPT1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000795 EF_GTP-bd_dom
     IPR004160 Transl_elong_EFTu/EF1A_C
     IPR004161 Transl_elong_EFTu/EF1A_2
     IPR009000 Transl_elong_init/rib_B-barrel
     IPR009001 Transl_elong_EF1A/Init_IF2_C

    Graphical View of Domain Structure for InterPro Entry P15170

    ProtoNet protein and cluster: P15170

    1 Blocks protein family: IPB004160 Elongation factor Tu

    UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170
    Similarity: Belongs to the GTP-binding elongation factor family. ERF3 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170
    Function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the
    activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which
    recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop
    codons

         Genatlas biochemistry entry for GSPT1:
    peptide chain factor release 3,interacting with and stimulating ERF1,controlled stop-codon directed release,mapping at
    the FRA16A locus

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    SwitchGear 3'UTR luciferase reporter plasmidGSPT1 3' UTR sequence
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003747translation release factor activity IMP15326224
    GO:0003924GTPase activity TAS15326224
    GO:0005515protein binding IPI12489690
    GO:0005525GTP binding IEA--


    GSPT1 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for GSPT1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  G0/1 arrest 
     Increased G1 DNA content  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA surveillance pathway
    mRNA surveillance pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for GSPT1):
        mRNA surveillance pathway


    GSPT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GSPT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/594 Interacting proteins for GSPT1 (P151702, 3 ENSP000003981314) via UniProtKB, MINT, STRING, and/or I2D (see all 594)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP2P497922, 3MINT-7945693 I2D: score=2 
    UPF1Q929002, 3, ENSP000002628034MINT-6539771 MINT-6539822 MINT-7945693 MINT-6539753 I2D: score=1 STRING: ENSP00000262803
    ETF1P624952, 3, ENSP000003537414MINT-7945693 MINT-6539807 MINT-6539753 I2D: score=3 STRING: ENSP00000353741
    PABPC1P119402, 3, ENSP000003130074MINT-6539792 MINT-7945693 I2D: score=3 STRING: ENSP00000313007
    ATXN1P542532, 3, ENSP000002447694MINT-2859396 I2D: score=2 STRING: ENSP00000244769
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS2511002
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS15326224
    GO:0006184GTP catabolic process TAS15326224
    GO:0006479protein methylation IDA18539146


    GSPT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GSPT1

    1 HMDB Compound for GSPT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for GSPT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    Search CenterWatch for drugs/clinical trials and news about GSPT1 / ERF3A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSPT1 gene (3 alternative transcripts): 
    NM_001130006.1  NM_001130007.1  NM_002094.3  

    Unigene Cluster for GSPT1:

    G1 to S phase transition 1
    Hs.528780  [show with all ESTs]
    Unigene Representative Sequence: NM_001130007
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434724(uc002dbu.3 uc002dbt.3 uc010bux.3) ENST00000439887
    ENST00000565267 ENST00000563468 ENST00000420576 ENST00000564790 ENST00000562794
    ENST00000568849 ENST00000567631 ENST00000562169

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    hsa-miR-579 hsa-miR-3678-3p hsa-miR-607 hsa-miR-4272 hsa-miR-128 hsa-miR-3138 hsa-miR-342-3p hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidGSPT1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK095367.1 AK095483.1 AK096386.1 AK290382.1 AK315267.1 BC008391.1 BC009503.2 BT006722.1 
    X17644.1 

    22 DOTS entries:

    DT.454604  DT.99988904  DT.100683056  DT.446626  DT.97847629  DT.95135414  DT.120689640  DT.120689662 
    DT.97847628  DT.120689743  DT.309978  DT.86845343  DT.101976268  DT.91695202  DT.91758716  DT.95135409 
    DT.120689650  DT.120689654  DT.91758717  DT.95114873  DT.95135413  DT.91851060 

    24/512 AceView cDNA sequences (see all 512):

    W76081 BQ447004 AA731776 BQ574806 BT006722 CB044892 CN479087 AI401471 
    AV709298 AA995745 BE221222 BM711311 CF136699 BE872397 AA505929 BM977577 
    AA847969 CB160074 AA133459 C00776 AI342286 AA706417 AI168002 AA039996 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GSPT1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:        -                                         -                                                         
    SP2:        -                                         -                                                         
    SP3:                                                                                                            
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for GSPT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSPT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAATAAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GSPT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSPT1

    SOURCE GeneReport for Unigene cluster: Hs.528780
        SABiosciences Custom PCR Arrays for GSPT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSPT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for GSPT1 gene from 10/39 species (see all 39)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves GSPT11 G1 to S phase transition 1 84.94(n)
    91(a)
      768522  NM_001135677.1  NP_001129149.1 
    lizard
    (Anolis carolinensis)
    Reptilia GSPT16
    --
    94(a)
    1 → many
    GL343580.1(1061-18633)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.78102 Xenopus laevis (clone XLSUP35) SUP35 mRNA, 3' end of more 82.54(n)    L37045.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gspt12 G1 to S phase transition 1 76.76(n)   325284  BC053244.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Elf1 , 3 translational termination translation
    termination more3
    Ef1alpha-like factor1
    74(a)3
    59.54(n)1
    64.1(a)1
      346581  NM_057911.31  NP_477259.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H19N07.13
    erfa-31
    elongation factor3
    Protein ERFA-31
    59(a)3
    60.24(n)1
    59.54(a)1
      V(11113044-11115666)3
    1795371  NM_073423.31  NP_505824.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUP351 Sup35p 56.59(n)
    51.74(a)
      851752   NP_010457.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G180701 G1 to S phase transition protein 57.95(n)
    54.15(a)
      838387  NM_001035986.1  NP_001031063.1 
    rice
    (Oryza sativa)
    Liliopsida Os.169252 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.51(n)    AK105823.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria cysN6
    sulfate adenylyltransferase, subunit 1
    23(a)
    1 → many
    Chromosome(2872014-2873441)


    ENSEMBL Gene Tree for GSPT1 (if available)
    TreeFam Gene Tree for GSPT1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSPT1 gene
    HBS1L2  GSPT22  
    9 SIMAP similar genes for GSPT1 using alignment to 5 protein entries:     ERF3A_HUMAN (see all proteins):
    GSPT2    EEF1A1    HBS1L    EEF1A2    EEF1A1P5    DKFZp434G247
    EEF1A1L14    PTI-1    EEF1A

    GSPT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GSPT1
    PGOHUM00000242886


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/928 NCBI SNPs in GSPT1 are shown (see all 928    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894273411,2
    --11961585(+) GCACAC/TTGAAT 3 -- int10--------
    rs1402955321,2
    C,--11961659(+) AGTTC-/TAATAATA 3 -- int10--------
    rs104927661,2
    C,F,H,--11961672(-) GAAACG/ATCAAT 3 -- int123Minor allele frequency- A:0.07NS NA EA WA 1814
    rs1996392241,2
    --11961722(+) TCTAG-/TTAT  
            
    TTATT
    3 -- int10--------
    rs336601,2
    C,F,O,A,H,--11961858(-) TAATAG/AGCTCT 3 -- int138Minor allele frequency- A:0.40NA EA NS WA CSA 3086
    rs1395138321,2
    --11961976(+) CAAACA/GACAAA 3 -- int10--------
    rs1810735251,2
    --11962118(+) TACAAA/CTCGTA 3 -- ut310--------
    rs1846323431,2
    --11962121(+) AAATCA/GTAAGA 3 -- ut310--------
    rs1496820821,2
    --11962163(+) CCATGC/TTTTGG 3 -- ut310--------
    rs1453929381,2
    C,--11962177(+) AGGCT-/AAAAAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for GSPT1 (11961985 - 12010519 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for GSPT1
         1 CNV: 102214
         3 Indels: 45400 49648 61493
    Human Gene Mutation Database (HGMD): GSPT1

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GSPT1 for disorders           About GeneDecksing

    OMIM gene information: 139259    OMIM disorders: --

    7 diseases for GSPT1:    About MalaCards
    gastric cancer    breast cancer    ataxia    schizophrenia
    tuberculosis    malaria    mycobacterium tuberculosis


    Export disorders for GSPT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSPT1 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with GSPT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. (PubMed id 2511002)1, 2, 3 Hoshino S.... Ui M. (1989)
    2. Molecular basis of eRF3 recognition by the MLLE domai n of poly(A)-binding protein. (PubMed id 20418951)1, 2 Kozlov G. and Gehring K. (2010)
    3. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PubMed id 19417104)1, 2 Yamashita A....Ohno S. (2009)
    4. G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1. (PubMed id 17700517)1, 3 Lee J.A....Cho S. (2008)
    5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    6. Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway. (PubMed id 17562865)1, 9 Chauvin C.... Jean-Jean O. (2007)
    7. Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. (PubMed id 15987998)1, 9 Chauvin C....Jean-Jean O. (2005)
    8. Differential expression of GSPT1 GGCn alleles in canc er. (PubMed id 19963113)1, 9 Malta-Vacas J....Brito M. (2009)
    9. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. (PubMed id 12865429)1, 9 Hegde R....Alnemri E.S. (2003)
    10. Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1. (PubMed id 1574740)1, 9 Ozawa K....Hanaoka F. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2935 HGNC: 4621 AceView: GSPT1 Ensembl:ENSG00000103342 euGenes: HUgn2935
    ECgene: GSPT1 Kegg: 2935 H-InvDB: GSPT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSPT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSPT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSPT1 gene:
    Search GeneIP for patents involving GSPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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