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GSPT1 Gene

protein-coding GIFtS: 66

GC16M011874

G1 to S phase transition 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
551G9.2 ^²
ERF3A ^³
ETF3A ^¹, ²
FLJ38048 ^²
FLJ39067 ^²
GST1 ^¹, ²
eRF3a ^¹, ², ³

Descriptions
Eukaryotic peptide chain release factor subunit 3a ^³
G1 to S phase transition 1 ^²
G1 to S phase transition protein ^²
G1 to S phase transition protein 1 homolog ^³

External Ids
HGNC: 4621¹
Entrez Gene: 2935²
UniProtKB: P15170³
Ensembl: ENSG00000103342⁷

Search outside databases for aliases for GSPT1 gene

Previous GC identifers: GC16M011749 GC16M012118 GC16M011932

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170

Function: Involved in translation termination in response to the termination codons UAA, UAG and

UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth

Gene Wiki entry for GSPT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GSPT1 gene

Entrez Gene cytogenetic band: 16p13.1 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13.1

GSPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M011874: (about GC identifiers)

Start:	11,874,040 bp from pter
End:	11,917,313 bp from pter
Size:	43,274 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170 (See protein sequence)

Recommended Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Size: 499 amino acids; 55756 Da

Subunit: Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or

ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001123478.1 NP_001123479.1 NP_002085.2

ENSEMBL proteins:

ENSP00000219627

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (eRF3/GSPT1 )
	Human Recombinant Proteins from Abnova (GSPT1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	NAS	15326224

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Antibodies for GSPT1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GSPT1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (eRF3/GSPT1 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GSPT1)
	Novus Biologicals Antibody for GSPT1

Assays for GSPT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P15170

ProtoNet protein and cluster: P15170

1 Blocks protein family: IPB004160 Elongation factor Tu

UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170

Similarity: Belongs to the GTP-binding elongation factor family. ERF3 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSPT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GSPT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130006

Applied Biosystems Silencer® siRNAs for GSPT1

Sigma-Aldrich siRNA and siRNA Panels for GSPT1

Sigma-Aldrich shRNA for GSPT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GSPT1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130006
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130006
untagged cDNA clones in CMV expression vector (see all 4): NM_001130006

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002094

UniProtKB/Swiss-Prot: ERF3A_HUMAN, P15170

Function: Involved in translation termination in response to the termination codons UAA, UAG and

UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth

Genatlas biochemistry entry for GSPT1:

peptide chain factor release 3,interacting with and stimulating ERF1,controlled stop-codon directed

release,mapping at the FRA16A locus

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003747	translation release factor activity	IMP	15326224
GO:0003924	GTPase activity	TAS	15326224
GO:0005515	protein binding	IPI	9620853 9712840 12489690
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for GSPT1

5/6 Interacting proteins for GSPT1 (P15170² ENSP00000219627³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UPF1	Q92900², ENSP00000262803³	MINT-6539771 MINT-6539822 MINT-6539753 STRING (score=.867)
ETF1	P62495², ENSP00000353741³	MINT-6539807 MINT-6539753 STRING (score=.998)
PABPCP5	P11940², ENSP00000313007³	MINT-6539792 STRING (score=.873)
ATXN1	P54253²	MINT-2859396
PABPC1	P11940²	MINT-6539792

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	TAS	2511002
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	15326224
GO:0006412	translation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GSPT1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSPT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GSPT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130006

Sigma-Aldrich siRNA and siRNA Panels for GSPT1

Sigma-Aldrich shRNA for GSPT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001130006 NM_001130007 NM_002094

REFSEQ mRNAs for GSPT1 gene (3 alternative transcripts):

NM_001130006.1 NM_001130007.1 NM_002094.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001130006 NM_001130007 NM_002094

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001130006
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001130006
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001130006

Additional cDNA sequence:

AK095367.1 AK095483.1 AK096386.1 AK290382.1 AK315267.1 BC008391.1 BC009503.2 BT006722.1

CR593395.1 CR594646.1 X17644.1

22 DOTS entries:

DT.454604 DT.99988904 DT.446626 DT.97847629 DT.100683056 DT.95135414 DT.120689640 DT.120689662

DT.97847628 DT.120689743 DT.309978 DT.86845343 DT.101976268 DT.91758716 DT.95135409 DT.120689650

DT.120689654 DT.91695202 DT.91758717 DT.91851060 DT.95114873 DT.95135413

24/512 AceView cDNA sequences (see all 512 ):

AI991920 AA505929 BQ447004 BU182937 BE872397 AW304874 AA962601 BX477370

AA329788 AA847969 CB215506 D12056 AA706417 AA039996 AI040556 BI861124

AI301584 CR593395 BU070633 CB161307 AA995745 AA450256 AK096386 CB242406

highest scoring ESTs for GSPT1:

X17644 AA083295 AU100047 AU126336 AU128425 AU128450 AU128549 AU129233 AW245830 AW328500

Unigene Cluster for GSPT1:

G1 to S phase transition 1

Hs.528780 [show with all ESTs]

Unigene Representative Sequence: NM_001130007

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GSPT1

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16
SP1:			-														-
SP2:			-														-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for GSPT1

1 Ensembl transcript including schematic representation:

ENST00000219627

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GSPT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GSPT1

¹ / ² / ³

15 probe-sets matching GSPT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
58486_at²^{, 3}	U95-C	1	1.00	1.00	0.93	0.84	N31268	0.20	1.00	0.72	1
64091_at²	U95-C	1	1.00	1.00	0.74	1.20	--	--	--	--	--
81055_at²^{, 3}	U95-E	1	1.00	1.00	0.35	1.14	AL079436	0.40	1.00	0.76	1
33932_at²^{, 3}	U95-A	2	1.00	0.94	0.59	0.91	X17644	1.00	0.87	0.94	1
80058_at²^{, 3}	U95-D	1	0.94	1.00	0.90	0.91	AA121686	0.20	1.00	0.72	1
201912_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002094	0.60	1.00	0.82	1
225276_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA143579	0.20	1.00	0.72	1
234975_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE544748	0.20	1.00	0.72	1
215438_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE906054	0.20	1.00	0.72	1
217595_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AV701723	0.20	1.00	0.72	1
201912_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225276_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234975_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215438_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217595_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks GSPT1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAATAAAAT

SOURCE GeneReport for Unigene cluster: Hs.528780
Expression variation in blood from EXPOLDB for GSPT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GSPT1 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GSPT1¹	--	G1 to S phase transition 1	94.32(n) 98.2(a)	479846 XM_536971.2 XP_536971.1
chimpanzee (Pan troglodytes)	GSPT1¹	--	G1 to S phase transition 1	99.75(n) 100(a)	739261 XM_001140542.1 XP_001140542.1
cow (Bos taurus)	GSPT1¹	--	G1 to S phase transition 1	94.46(n) 99.2(a)	532337 XM_610849.3 XP_610849.3
rat (Rattus norvegicus)	Gspt1¹	--	G1 to S phase transition 1	93.05(n) 98.6(a)	24420 NM_001003978.1 NP_001003978.1
mouse (Mus musculus)	Gspt1^{1, 5}	16 (3.80 cM)⁵	G1 to S phase transition 1^{1, 5}	93.39(n)¹ 98.6(a)¹	14852¹ NM_146066.1¹ NP_666178.1¹ AA386565⁵ AB003502⁵ (see all 37)

About this table Species with no ortholog for GSPT1

ENSEMBL Gene Tree for GSPT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GSPT1 gene

GSPT2² HBS1L² TUFM²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/318 NCBI SNPs in GSPT1 are shown (see all 318 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs40311^1,2	A,C,F,H,O	11870691(-)	`TGTTTG/CTTTCG`	3	--	ut3¹		16		MN NA EU EA WA	1584
	rs467106^1,2	A,C,F,H	11917867(-)	`GTGGAA/GAGAGA`	2	--	ut5¹ ng3¹ trp³		5		MN EU EA WA	602
	rs464017^1,2	C,F,H,O	11917945(-)	`TAAAAT/GGAAAT`	2	--	ng3¹ ut5¹		6		MN EU EA WA	1524
	rs2051546^1,2	C,F,H,O	11873242(-)	`ATGAAC/TCACAG`	3	--	ut3¹		9		MN EU EA WA NA	810
	rs33659^1,2	A,C,F,H	11870862(-)	`TTGGCC/TTACCT`	3	--	ut3¹		9		MN EU EA WA	1022
	rs434762^1,2	A,C,F,H	11917282(-)	`GCTGCT/CGCCGC`	2	--	ut5¹ ese³		4		EU EA WA	420
	rs2075151^1,2	A,C,F	11917635(-)	`CCCCCC/AACCAG`	2	--	ut5¹ ng3¹		3		EA MN	1846
--	rs11641520^1,2	A,C	11872891(+)	`ctgcaC/Gtccag`	3	--	ut3¹		0	--	--	--	--
	rs2075150^1,2	C,F	11917771(-)	`TCTTCC/TCCATG`	2	--	ng3¹ ut5¹ trp³		1		EA	1108
--	rs382158^1,2	A,C	11918619(-)	`TTGTTA/GGGTTT`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for GSPT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 139259

Human Gene Mutation Database: GSPT1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/29 PubMed articles for GSPT1 gene (see all 29 ):

A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. (PubMed id 2511002)^{2, 3, 4} Hoshino S.... Ui M. (1989)
G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1. (PubMed id 17700517)^{2, 3} Lee J.A....Cho S. (2008)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{3, 4} Loftus B.J....Adams M.D. (1999)
Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway. (PubMed id 17562865)^{1, 3} Chauvin C....Jean-Jean O. (2007)
Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. (PubMed id 15987998)^{1, 3} Chauvin C....Jean-Jean O. (2005)
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. (PubMed id 12865429)^{1, 3} Hegde R....Alnemri E.S. (2003)
Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1. (PubMed id 1574740)^{1, 3} Ozawa K....Hanaoka F. (1992)
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)³ Martins-de-Souza D....Turck C.W. (2009)
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PubMed id 19417104)⁴ Yamashita A....Ohno S. (2009)
Proteasomal degradation of human release factor eRF3a regulates translation termination complex formation. (PubMed id 18083835)³ Chauvin C. and Jean-Jean O. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2935	HGNC: 4621	AceView: GSPT1	Ensembl:ENSG00000103342	euGenes: HUgn2935
ECgene: GSPT1	H-InvDB: GSPT1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for GSPT1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GSPT1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GSPT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GSPT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GSPT1		Antibodies for GSPT1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GSPT1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GSPT1)
	Antibodies (GSPT1)
	Chimera RNAi (GSPT1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (eRF3/GSPT1 )
	Antibodies (eRF3/GSPT1 )

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Search Tocris compounds for GSPT1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GSPT1

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GSPT1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for GSPT1

Summaries
for GSPT1

Genomic Location
for GSPT1

Proteins
for GSPT1

Protein Domains/
Families
for GSPT1

Gene Function
for GSPT1

Pathways & Interactions
for GSPT1

Drugs & Compounds
for GSPT1

Transcripts
for GSPT1

Expression
for GSPT1

Orthologs
for GSPT1

Paralogs
for GSPT1

SNPs/Variants
for GSPT1

Disorders & Mutations
for GSPT1

Medical News
for GSPT1

Publications
for GSPT1

Search for GSPT1

Genome Databases showing GSPT1

Other Databases showing GSPT1

Specialized Databases showing GSPT1

Licensable Technologies
for GSPT1

Services
for GSPT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GSPT1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor GSPT1

Summariesfor GSPT1

Genomic Locationfor GSPT1

Proteinsfor GSPT1

Protein Domains/Familiesfor GSPT1

Gene Functionfor GSPT1

Pathways & Interactionsfor GSPT1

Drugs & Compoundsfor GSPT1

Transcriptsfor GSPT1

Expression for GSPT1

Orthologsfor GSPT1

Paralogsfor GSPT1

SNPs/Variantsfor GSPT1

Disorders & Mutationsfor GSPT1

Medical Newsfor GSPT1

Publicationsfor GSPT1

Search for GSPT1

Genome Databases showing GSPT1

Other Databases showing GSPT1

Specialized Databases showing GSPT1

Licensable Technologiesfor GSPT1

Servicesfor GSPT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GSPT1

Summaries
for GSPT1

Genomic Location
for GSPT1

Proteins
for GSPT1

Protein Domains/
Families
for GSPT1

Gene Function
for GSPT1

Pathways & Interactions
for GSPT1

Drugs & Compounds
for GSPT1

Transcripts
for GSPT1

Expression
for GSPT1

Orthologs
for GSPT1

Paralogs
for GSPT1

SNPs/Variants
for GSPT1

Disorders & Mutations
for GSPT1

Medical News
for GSPT1

Publications
for GSPT1

Licensable Technologies
for GSPT1

Services
for GSPT1