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Aliases for GSPT1 Gene

Aliases for GSPT1 Gene

  • G1 To S Phase Transition 1 2 3
  • Eukaryotic Peptide Chain Release Factor Subunit 3a 3 4
  • G1 To S Phase Transition Protein 1 Homolog 3 4
  • ERF3a 3 4
  • Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A 3
  • 551G9.2 3
  • ETF3A 3
  • GST1 3

External Ids for GSPT1 Gene

Summaries for GSPT1 Gene

GeneCards Summary for GSPT1 Gene

GSPT1 (G1 To S Phase Transition 1) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway. GO annotations related to this gene include GTP binding and translation release factor activity. An important paralog of this gene is HBS1L.

UniProtKB/Swiss-Prot for GSPT1 Gene

  • Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons

Gene Wiki entry for GSPT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSPT1 Gene

Genomics for GSPT1 Gene

Genomic Location for GSPT1 Gene

Start:
11,868,128 bp from pter
End:
11,916,662 bp from pter
Size:
48,535 bases
Orientation:
Minus strand

Genomic View for GSPT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSPT1 Gene

Regulatory Elements for GSPT1 Gene

Proteins for GSPT1 Gene

  • Protein details for GSPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15170-ERF3A_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    Protein Accession:
    P15170
    Secondary Accessions:
    • J3KQG6
    • Q96GF2

    Protein attributes for GSPT1 Gene

    Size:
    499 amino acids
    Molecular mass:
    55756 Da
    Quaternary structure:
    • Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

    Three dimensional structures from OCA and Proteopedia for GSPT1 Gene

    Alternative splice isoforms for GSPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSPT1 Gene

Proteomics data for GSPT1 Gene at MOPED

Post-translational modifications for GSPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys196, Lys490, and Lys74

No data available for DME Specific Peptides for GSPT1 Gene

Domains for GSPT1 Gene

UniProtKB/Swiss-Prot:

ERF3A_HUMAN
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.:
    • P15170
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.:
    • P15170
genes like me logo Genes that share domains with GSPT1: view

No data available for Gene Families for GSPT1 Gene

Function for GSPT1 Gene

Molecular function for GSPT1 Gene

GENATLAS Biochemistry: peptide chain factor release 3,interacting with and stimulating ERF1,controlled stop-codon directed release,mapping at the FRA16A locus
UniProtKB/Swiss-Prot Function: Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons

Gene Ontology (GO) - Molecular Function for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003747 translation release factor activity IMP 15326224
GO:0003924 GTPase activity TAS 15326224
GO:0005515 protein binding IPI 12489690
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GSPT1: view
genes like me logo Genes that share phenotypes with GSPT1: view

miRNA for GSPT1 Gene

miRTarBase miRNAs that target GSPT1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GSPT1 Gene

Localization for GSPT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSPT1 Gene COMPARTMENTS Subcellular localization image for GSPT1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 15326224
genes like me logo Genes that share ontologies with GSPT1: view

Pathways for GSPT1 Gene

SuperPathways for GSPT1 Gene

Superpath Contained pathways
1 mRNA surveillance pathway
genes like me logo Genes that share pathways with GSPT1: view

Pathways by source for GSPT1 Gene

1 KEGG pathway for GSPT1 Gene

Gene Ontology (GO) - Biological Process for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 2511002
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS 15326224
GO:0006184 obsolete GTP catabolic process --
GO:0006415 translational termination IMP 15326224
GO:0006479 protein methylation IDA 18539146
genes like me logo Genes that share ontologies with GSPT1: view

Compounds for GSPT1 Gene

(1) HMDB Compounds for GSPT1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for GSPT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target
genes like me logo Genes that share compounds with GSPT1: view

Transcripts for GSPT1 Gene

Unigene Clusters for GSPT1 Gene

G1 to S phase transition 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSPT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for GSPT1 Gene

GeneLoc Exon Structure for
GSPT1
ECgene alternative splicing isoforms for
GSPT1

Expression for GSPT1 Gene

mRNA expression in normal human tissues for GSPT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSPT1 Gene

SOURCE GeneReport for Unigene cluster for GSPT1 Gene Hs.528780

genes like me logo Genes that share expressions with GSPT1: view

Orthologs for GSPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSPT1 36
  • 97.49 (n)
  • 97.68 (a)
GSPT1 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSPT1 36
  • 94.01 (n)
  • 97.39 (a)
GSPT1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSPT1 36
  • 94.24 (n)
  • 98.19 (a)
GSPT1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gspt1 36
  • 91.75 (n)
  • 95.25 (a)
Gspt1 16
Gspt1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 86 (a)
ManyToMany
-- 37
  • 94 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
ManyToMany
-- 37
  • 98 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100911685 36
  • 91.42 (n)
  • 95.74 (a)
chicken
(Gallus gallus)
Aves GSPT1 36
  • 83.88 (n)
  • 89.44 (a)
GSPT1 37
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 94 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.7810 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gspt1 36
  • 82.45 (n)
  • 89.26 (a)
Str.3230 36
zebrafish
(Danio rerio)
Actinopterygii gspt1 36
gspt1 36
  • 73.87 (n)
  • 83.6 (a)
gspt1 37
  • 80 (a)
ManyToMany
gspt1l 37
  • 79 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009310 36
  • 64 (n)
  • 75.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Elf 36
  • 63.78 (n)
  • 71.67 (a)
Elf 37
  • 57 (a)
OneToMany
Elf 38
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea erfa-3 37
  • 56 (a)
OneToMany
H19N07.1 38
  • 59 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL145W 36
  • 60.46 (n)
  • 57.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUP35 36
  • 60.69 (n)
  • 57.78 (a)
SUP35 37
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D17424g 36
  • 61.32 (n)
  • 59.43 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1162 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18070 36
  • 60.27 (n)
  • 58.78 (a)
rice
(Oryza sativa)
Liliopsida Os.16925 36
Os04g0270100 36
  • 61.58 (n)
  • 59.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04790 36
  • 58.33 (n)
  • 59.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sup35 36
  • 58.45 (n)
  • 54.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9703 37
  • 68 (a)
OneToMany
Species with no ortholog for GSPT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSPT1 Gene

ENSEMBL:
Gene Tree for GSPT1 (if available)
TreeFam:
Gene Tree for GSPT1 (if available)

Paralogs for GSPT1 Gene

Paralogs for GSPT1 Gene

Selected SIMAP similar genes for GSPT1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GSPT1 Gene

genes like me logo Genes that share paralogs with GSPT1: view

Variants for GSPT1 Gene

Sequence variations from dbSNP and Humsavar for GSPT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs15194 -- 11,868,493(+) TTTCT(A/G)AGAGC utr-variant-3-prime
rs28279 -- 11,874,698(-) AAATT(G/T)TATAA intron-variant
rs33619 -- 11,915,084(-) TACCC(A/C)CTTGA intron-variant, utr-variant-5-prime
rs33620 -- 11,914,689(-) TAGGA(C/G)ACTAT intron-variant
rs33621 -- 11,914,656(-) TGAAG(C/T)TTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSPT1 Gene

Variant ID Type Subtype PubMed ID
nsv1735 CNV Loss 18451855
esv2651942 CNV Deletion 19546169
esv2343500 CNV Deletion 18987734
esv2713982 CNV Deletion 23290073
esv7500 CNV Loss 19470904
nsv519892 CNV Loss 19592680
nsv524025 CNV Loss 19592680
nsv905347 CNV Gain 21882294

Relevant External Links for GSPT1 Gene

HapMap Linkage Disequilibrium report
GSPT1
Human Gene Mutation Database (HGMD)
GSPT1

Disorders for GSPT1 Gene

Relevant External Links for GSPT1

Genetic Association Database (GAD)
GSPT1
genes like me logo Genes that share disorders with GSPT1: view

No data available for UniProtKB/Swiss-Prot for GSPT1 Gene

Publications for GSPT1 Gene

  1. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. (PMID: 2511002) Hoshino S. … Ui M. (EMBO J. 1989) 2 3 4
  2. Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1. (PMID: 1574740) Ozawa K. … Hanaoka F. (Somat. Cell Mol. Genet. 1992) 3 23
  3. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. (PMID: 12865429) Hegde R. … Alnemri E.S. (J. Biol. Chem. 2003) 3 23
  4. Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. (PMID: 15987998) Chauvin C. … Jean-Jean O. (Mol. Cell. Biol. 2005) 3 23
  5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4

Products for GSPT1 Gene

Sources for GSPT1 Gene

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