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Aliases for GSPT1 Gene

Aliases for GSPT1 Gene

  • G1 To S Phase Transition 1 2 3 5
  • Eukaryotic Peptide Chain Release Factor Subunit 3a 3 4
  • G1 To S Phase Transition Protein 1 Homolog 3 4
  • ERF3a 3 4
  • Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3A 3
  • 551G9.2 3
  • ETF3A 3
  • GST1 3

External Ids for GSPT1 Gene

Previous GeneCards Identifiers for GSPT1 Gene

  • GC16M011749
  • GC16M012118
  • GC16M011932
  • GC16M011874
  • GC16M011961
  • GC16M011878

Summaries for GSPT1 Gene

GeneCards Summary for GSPT1 Gene

GSPT1 (G1 To S Phase Transition 1) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Translational Control. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is GSPT2.

UniProtKB/Swiss-Prot for GSPT1 Gene

  • Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Wiki entry for GSPT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSPT1 Gene

Genomics for GSPT1 Gene

Regulatory Elements for GSPT1 Gene

Enhancers for GSPT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around GSPT1 on UCSC Golden Path with GeneCards custom track

Promoters for GSPT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSPT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSPT1 Gene

Chromosome:
16
Start:
11,868,128 bp from pter
End:
11,916,662 bp from pter
Size:
48,535 bases
Orientation:
Minus strand

Genomic View for GSPT1 Gene

Genes around GSPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSPT1 Gene

Proteins for GSPT1 Gene

  • Protein details for GSPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15170-ERF3A_HUMAN
    Recommended name:
    Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    Protein Accession:
    P15170
    Secondary Accessions:
    • J3KQG6
    • Q96GF2

    Protein attributes for GSPT1 Gene

    Size:
    499 amino acids
    Molecular mass:
    55756 Da
    Quaternary structure:
    • Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

    Three dimensional structures from OCA and Proteopedia for GSPT1 Gene

    Alternative splice isoforms for GSPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSPT1 Gene

Post-translational modifications for GSPT1 Gene

  • Ubiquitination at Lys 74
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GSPT1 Gene

Domains & Families for GSPT1 Gene

Suggested Antigen Peptide Sequences for GSPT1 Gene

Graphical View of Domain Structure for InterPro Entry

P15170

UniProtKB/Swiss-Prot:

ERF3A_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
genes like me logo Genes that share domains with GSPT1: view

No data available for Gene Families for GSPT1 Gene

Function for GSPT1 Gene

Molecular function for GSPT1 Gene

GENATLAS Biochemistry:
peptide chain factor release 3,interacting with and stimulating ERF1,controlled stop-codon directed release,mapping at the FRA16A locus
UniProtKB/Swiss-Prot Function:
Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Gene Ontology (GO) - Molecular Function for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003747 translation release factor activity IMP 15326224
GO:0003924 GTPase activity TAS 15326224
GO:0005515 protein binding IPI 9620853
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GSPT1: view
genes like me logo Genes that share phenotypes with GSPT1: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSPT1 Gene

Localization for GSPT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSPT1 Gene COMPARTMENTS Subcellular localization image for GSPT1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 15326224
GO:0005829 cytosol IEA --
GO:0018444 translation release factor complex IBA --
genes like me logo Genes that share ontologies with GSPT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GSPT1 Gene

Pathways & Interactions for GSPT1 Gene

genes like me logo Genes that share pathways with GSPT1: view

Pathways by source for GSPT1 Gene

1 Cell Signaling Technology pathway for GSPT1 Gene
1 KEGG pathway for GSPT1 Gene

Gene Ontology (GO) - Biological Process for GSPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 2511002
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS 15326224
GO:0002184 cytoplasmic translational termination IBA --
GO:0006479 protein methylation IDA 18539146
genes like me logo Genes that share ontologies with GSPT1: view

No data available for SIGNOR curated interactions for GSPT1 Gene

Drugs & Compounds for GSPT1 Gene

(2) Drugs for GSPT1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GSPT1: view

Transcripts for GSPT1 Gene

Unigene Clusters for GSPT1 Gene

G1 to S phase transition 1:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSPT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for GSPT1 Gene

GeneLoc Exon Structure for
GSPT1
ECgene alternative splicing isoforms for
GSPT1

Expression for GSPT1 Gene

mRNA expression in normal human tissues for GSPT1 Gene

Protein differential expression in normal tissues from HIPED for GSPT1 Gene

This gene is overexpressed in Lymph node (11.0), Peripheral blood mononuclear cells (7.4), and Amniocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSPT1 Gene



Protein tissue co-expression partners for GSPT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GSPT1 Gene:

GSPT1

SOURCE GeneReport for Unigene cluster for GSPT1 Gene:

Hs.528780
genes like me logo Genes that share expression patterns with GSPT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GSPT1 Gene

Orthologs for GSPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSPT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSPT1 34
  • 94.01 (n)
  • 97.39 (a)
GSPT1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSPT1 34
  • 94.24 (n)
  • 98.19 (a)
GSPT1 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gspt1 34
  • 91.75 (n)
  • 95.25 (a)
Gspt1 16
Gspt1 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GSPT1 34
  • 97.49 (n)
  • 97.68 (a)
GSPT1 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911685 34
  • 91.42 (n)
  • 95.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
ManyToMany
-- 35
  • 94 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
ManyToMany
-- 35
  • 98 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GSPT1 34
  • 83.88 (n)
  • 89.44 (a)
GSPT1 35
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gspt1 34
  • 82.45 (n)
  • 89.26 (a)
Str.3230 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7810 34
zebrafish
(Danio rerio)
Actinopterygii gspt1 34
gspt1 34
  • 73.87 (n)
  • 83.6 (a)
gspt1 35
  • 80 (a)
ManyToMany
gspt1l 35
  • 79 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Elf 36
  • 74 (a)
Elf 34
  • 63.78 (n)
  • 71.67 (a)
Elf 35
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009310 34
  • 64 (n)
  • 75.76 (a)
worm
(Caenorhabditis elegans)
Secernentea H19N07.1 36
  • 59 (a)
erfa-3 35
  • 56 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL145W 34
  • 60.46 (n)
  • 57.08 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D17424g 34
  • 61.32 (n)
  • 59.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUP35 34
  • 60.69 (n)
  • 57.78 (a)
SUP35 35
  • 41 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18070 34
  • 60.27 (n)
  • 58.78 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1162 34
rice
(Oryza sativa)
Liliopsida Os.16925 34
Os04g0270100 34
  • 61.58 (n)
  • 59.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04790 34
  • 58.33 (n)
  • 59.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sup35 34
  • 58.45 (n)
  • 54.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9703 35
  • 68 (a)
OneToMany
Species where no ortholog for GSPT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSPT1 Gene

ENSEMBL:
Gene Tree for GSPT1 (if available)
TreeFam:
Gene Tree for GSPT1 (if available)

Paralogs for GSPT1 Gene

Paralogs for GSPT1 Gene

(7) SIMAP similar genes for GSPT1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GSPT1 Gene

genes like me logo Genes that share paralogs with GSPT1: view

Variants for GSPT1 Gene

Sequence variations from dbSNP and Humsavar for GSPT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3021065 -- 11,915,600(-) ccggg(C/T)cgggc intron-variant, reference, missense
rs3031121 -- 11,915,705(+) ccgcc(-/GCCGC/GCCGCC)ACTGC intron-variant, reference, frameshift-variant, cds-indel
rs3971907 -- 11,911,552(+) AGCTA(-/T)TTTTT intron-variant
rs9673473 -- 11,917,355(+) AGTGG(C/G)GCGAT upstream-variant-2KB
rs9923173 -- 11,916,902(+) GAAGT(A/G)GTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GSPT1 Gene

Variant ID Type Subtype PubMed ID
dgv1298n106 CNV deletion 24896259
esv2343500 CNV deletion 18987734
esv2651942 CNV deletion 19546169
esv2713982 CNV deletion 23290073
esv3553124 CNV deletion 23714750
esv7500 CNV loss 19470904
nsv1043909 CNV gain 25217958
nsv1151765 CNV deletion 26484159
nsv1735 CNV deletion 18451855
nsv519892 CNV loss 19592680
nsv524025 CNV loss 19592680
nsv571458 CNV gain 21841781
nsv958188 CNV deletion 24416366

Variation tolerance for GSPT1 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.44; 90.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSPT1 Gene

Human Gene Mutation Database (HGMD)
GSPT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSPT1 Gene

Disorders for GSPT1 Gene

Relevant External Links for GSPT1

Genetic Association Database (GAD)
GSPT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSPT1

No disorders were found for GSPT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSPT1 Gene

Publications for GSPT1 Gene

  1. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. (PMID: 2511002) Hoshino S. … Ui M. (EMBO J. 1989) 2 3 4 65
  2. Molecular basis of eRF3 recognition by the MLLE domain of poly(A)- binding protein. (PMID: 20418951) Kozlov G. … Gehring K. (PLoS ONE 2010) 3 4 65
  3. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PMID: 19417104) Yamashita A. … Ohno S. (Genes Dev. 2009) 3 4 65
  4. eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development. (PMID: 19424636) Malta-Vacas J. … Brito M. (Oncol. Rep. 2009) 3 22 65
  5. Differential expression of GSPT1 GGCn alleles in cancer. (PMID: 19963113) Malta-Vacas J. … Brito M. (Cancer Genet. Cytogenet. 2009) 3 22 65

Products for GSPT1 Gene

Sources for GSPT1 Gene

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