Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSN Gene

protein-coding GIFtS: 68
GCID: GC09P123971

gelsolin

(Previous names: gelsolin (amyloidosis, Finnish type) )

Explore 83 diseases affiliated with
GSN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Gelsolin¹		DKFZp313L0718¹
Actin-Depolymerizing Factor² ³		Gelsolin (Amyloidosis, Finnish Type)¹
ADF² ³		Brevin³
AGEL² ³		Brevin³

External Ids:	HGNC: 4620¹	Entrez Gene: 2934²	Ensembl: ENSG00000148180⁷	OMIM: 137350⁵	UniProtKB: P06396³

Export aliases for GSN gene to outside databases

Previous GC identifers: GC09P115166 GC09P115708 GC09P117515 GC09P119438 GC09P119406 GC09P121109 GC09P123070 GC09P093648

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSN:

The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange.

The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this

gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different

isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GELS_HUMAN, P06396

Function: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or

filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into

filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis

Gene Wiki entry for GSN (Gelsolin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSN gene promoter:
Sp1 HNF-4alpha2 GATA-1 NF-AT Evi-1 HNF-4alpha1 NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GSN promoter sequence

Search SABiosciences Chromatin IP Primers for GSN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q33

GSN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSN gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P123971: view genomic region (about GC identifiers)

Start:	123,970,075 bp from pter	End:	124,095,121 bp from pter
Size:	125,047 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GELS_HUMAN, P06396 (See protein sequence)

Recommended Name: Gelsolin precursor

Size: 782 amino acids; 85698 Da

Subunit: Binds to actin and to fibronectin

Subcellular location: Isoform 2: Cytoplasm, cytoskeleton

Subcellular location: Isoform 1: Secreted

6/35 PDB 3D structures from and Proteopedia for GSN (see all 35):

1C0F (3D)

1C0G (3D)

1D4X (3D)

1DEJ (3D)

1EQY (3D)

1ESV (3D)

Secondary accessions: A2A418 A8MUD1 A8MYN7 B7Z373 Q5T0I2 Q8WVV7

Alternative splicing, Alternative initiation: 3 isoforms: P06396-1 P06396-2 P06396-3 (Initiator Met-1 may be either removed, or N-acetylated)

Explore the universe of human proteins at neXtProt for GSN: NX_P06396

Post-translational modifications:

Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06396

GSN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (10 alternative transcripts):

NP_000168.1 NP_001121134.1 NP_001121135.2 NP_001121136.1 NP_001121137.1 NP_001121138.1 NP_001121139.1 NP_001244958.1

NP_001244959.1 NP_937895.1

ENSEMBL proteins:

ENSP00000362929 ENSP00000410657 ENSP00000404226 ENSP00000362924 ENSP00000362913

ENSP00000362912 ENSP00000362911 ENSP00000445823 ENSP00000411293 ENSP00000377882

ENSP00000409358 ENSP00000416586 ENSP00000340888 ENSP00000362914

Reactome Protein details: P06396
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: GSN OriGene Protein Over-expression Lysate: GSN OriGene Custom Protein Services for GSN
	GenScript Custom Purified and Recombinant Proteins Services for GSN
	Novus Biologicals GSN Proteins Novus Biologicals GSN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005829	cytosol	TAS	--
GO:0015629	actin cytoskeleton	IEA	--

GSN for ontologies About GeneDecksing

GSN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GSN
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for GSN (gelsolin)
	OriGene Antibodies (see all 4): GSN OriGene Custom Antibody Services for GSN
	GenScript Custom Superior Antibodies Services for GSN
	Novus Biologicals GSN Antibodies
	Abcam antibodies for GSN
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for GSN

Assay Products for GSN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for GSN
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GSN for domains About GeneDecksing

2 InterPro domains/families:

IPR007122 Gelsolin

IPR007123 Gelsolin_dom

Graphical View of Domain Structure for InterPro Entry P06396

ProtoNet protein and cluster: P06396

2 Blocks protein families:

IPB007122 Gelsolin family signature

IPB007123 Gelsolin region

UniProtKB/Swiss-Prot: GELS_HUMAN, P06396

Similarity: Belongs to the villin/gelsolin family

Similarity: Contains 6 gelsolin-like repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GELS_HUMAN, P06396

Function: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or

filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into

filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis

Genatlas biochemistry entry for GSN:

gelsolin,actin filaments severing and capping protein,expressed in macrophages,platelets,plasma,with homology to

villin,Ca2+ and polyphosphoinositide 4,5-biphosphate (PIP2)-regulated,implicated in actin remodeling in growing and in

apoptotic cells,cleaved by CASP3 to form a potential effector of morphologic change during apoptosis

miRNA Products:		miRTarBase miRNAs that target GSN: hsa-mir-124 (MIRT002639)

		OriGene 3'-UTR Clone (see all 8): GSN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate GSN:
		hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: GSN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSN (see all 7) OriGene shRNA RFP: GSN OriGene siRNA: GSN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GSN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSN (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSN (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): GSN (NM_001127665)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GSN
		Search LifeMap BioReagents cell lines for GSN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005509	calcium ion binding	TAS	1321812
GO:0005515	protein binding	IPI	17620599

GSN for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for GSN:

Decreased cilium length

Decreased cilium length after

Animal Models:
Mouse knock-out Gsn^tm1Djk for GSN
12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Gsn):

cardiovascular system	cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	nervous system	reproductive system
respiratory system	skeleton

GSN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic cleavage of cellular proteins

	Apoptotic cleavage of cellular proteins	1.00			Caspase-mediated cleavage of cytoskeletal proteins	0.32
	Apoptotic execution phase	0.73

Amyloid precursor proteins form ordered fibrils

Amyloid precursor proteins form ordered fibrils

1.00

Amyloids

0.43

Integrin Pathway

Integrin Pathway

1.00

Transendothelial Migration of Leukocytes

0.38

Regulation of Actin Cytoskeleton

Regulation of Actin Cytoskeleton

1.00

Regulation of actin cytoskeleton

0.58

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GSN (see all 7)

	Actin-Based Motility by Rho Family GTPases
	Guidance Cues and Growth Cone Motility
	Integrin Pathway
	Germ Cell-Sertoli Cell Junction Dynamics
	Transendothelial Migration of Leukocytes

2 Cell Signaling Technology (CST) Pathways for GSN

	Ca, cAMP and Lipid Signaling
	Cytoskeletal Signaling

5/7 BioSystems Pathways for GSN (see all 7)

	Senescence and Autophagy
	Regulation of Actin Cytoskeleton
	Caspase cascade in apoptosis
	EGF receptor (ErbB1) signaling pathway
	Osteopontin-mediated events

5/7 Reactome Pathways for GSN (see all 7)

	Amyloids
	Amyloid precursor proteins form ordered fibrils
	Apoptotic execution phase
	Apoptotic cleavage of cellular proteins
	Caspase-mediated cleavage of cytoskeletal proteins

2 Kegg Pathways (Kegg details for GSN):

	Fc gamma R-mediated phagocytosis
	Regulation of actin cytoskeleton

GSN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GSN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/82 Interacting proteins for GSN (P06396^{1, 2, 3} ENSP00000362924⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARRB1	P49407¹^,³	EBI-351506,EBI-2561130 I2D: score=1
ARRB2	P32121¹^,³	EBI-351506,EBI-714559 I2D: score=1
ACTA1	P68133²^,³, ENSP00000355645⁴	MINT-24898 I2D: score=5 STRING: ENSP00000355645
VDAC1	P21796²^,³, ENSP00000265333⁴	MINT-4792996 I2D: score=4 STRING: ENSP00000265333
ACTN4	O43707³, ENSP00000252699⁴	I2D: score=3 STRING: ENSP00000252699

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	TAS	--
GO:0007568	aging	IEA	--
GO:0008154	actin polymerization or depolymerization	--	--
GO:0014003	oligodendrocyte development	IEA	--

GSN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GSN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GSN

1 HMDB Compound for GSN About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for GSN About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Latrunculin A	--	--	target	--	10592235

10/78 Novoseek chemical compound relationships for GSN gene (see all 78) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
kabiramide c	85.6	3	16287234 (1), 14612571 (1)
pip2	79.4	45	9265648 (4), 9252353 (3), 1313007 (3), 1318302 (3) (see all 24)
phalloidin	68.2	15	8987989 (3), 7806519 (2), 12475760 (2), 1661732 (2) (see all 9)
apicidin	57.5	10	17257588 (5), 11085529 (3)
deoxypodophyllotoxin	51.2	2	11455440 (1)
cytochalasin d	51.1	5	12475760 (2), 9464993 (1), 11016945 (1), 14742433 (1)
phosphoinositide	50.6	13	11090061 (3), 11170411 (3), 8641669 (1), 10429191 (1) (see all 8)
calcium	45.4	190	9398317 (7), 8386174 (6), 10336615 (5), 12752443 (5) (see all 67)
jasplakinolide	40	3	10828033 (2), 15591047 (1)
potassium acetate	36.7	1	8425898 (1)

Search CenterWatch for drugs/clinical trials and news about GSN / GELS

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSN gene (10 alternative transcripts):

NM_000177.4 NM_001127662.1 NM_001127663.1 NM_001127664.1 NM_001127665.1 NM_001127666.1 NM_001127667.1 NM_001258029.1

NM_001258030.1 NM_198252.2

Unigene Cluster for GSN:

Gelsolin

Hs.522373 [show with all ESTs]

Unigene Representative Sequence: AF220263

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000373823(uc004bld.1 uc011lyj.1) ENST00000449773 ENST00000432226

ENST00000477863 ENST00000483960 ENST00000475428 ENST00000477104 ENST00000373818(uc004blf.1)

ENST00000485767 ENST00000373807(uc004blg.1) ENST00000373806 ENST00000373805

ENST00000477553 ENST00000545652 ENST00000436847(uc010mvq.1) ENST00000394353(uc010mvr.1)

ENST00000449733(uc010mvu.1) ENST00000412819(uc010mvs.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 8): GSN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate GSN:
		hsa-miR-124 hsa-miR-506
		SwitchGear 3'UTR luciferase reporter plasmid: GSN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSN (see all 7) OriGene shRNA RFP: GSN OriGene siRNA: GSN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSN (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSN (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): GSN (NM_001127665)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GSN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSN

Additional cDNA sequence:

AF220263.1 AK096280.1 AK295201.1 AK295572.1 AK297870.1 AK299453.1 AK300631.1 AK304629.1

AK304675.1 AK307859.1 AK315494.1 AL832614.1 BC017491.1 BC026033.1 BX647999.1 X04412.1

24/67 DOTS entries (see all 67):

DT.100881707 DT.91894886 DT.453410 DT.100881695 DT.91771655 DT.95354439 DT.97860794 DT.100881704

DT.95309109 DT.100881699 DT.121211956 DT.121211910 DT.100881698 DT.121211858 DT.100039145 DT.121211779

DT.100881713 DT.95206638 DT.87017285 DT.91862299 DT.437979 DT.100881709 DT.121211776 DT.100881693

24/954 AceView cDNA sequences (see all 954):

AJ574512 BQ678899 AA743280 N54948 AJ573228 BM663114 BM758042 AL047355

BF928277 AI460213 BU620811 BQ685383 BM664179 CA427016 BM669896 BP371939

F27467 AL602858 BM783032 CB270013 BI819590 BU788993 BU172279 BM672813

GeneLoc Exon Structure

5/44 Alternative Splicing Database (ASD) splice patterns (SP) for GSN (see all 44) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c	^	14a	·	14b	·	14c	^	15a	·	15b	·
SP1:					-		-		-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP2:									-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:																																											-		-		-		-
SP4:
SP5:																	-		-		-						-		-		-		-				-		-		-								-

ExUns:	15c	·	15d	·	15e	^	16	^	17a	·	17b	·	17c	·	17d	·	17e	·	17f	·	17g	^	18a	·	18b	·	18c	·	18d	·	18e	^	19a	·	19b	^	20a	·	20b	·	20c	·	20d	^	21a	·	21b	·	21c	·	21d	^
SP1:																							-														-								-
SP2:																							-														-								-
SP3:																							-														-								-
SP4:																																													-
SP5:

ExUns:	22	^	23	^	24a	·	24b	·	24c	^	25	^	26	^	27a	·	27b	·	27c	^	28	^	29a	·	29b	^	30a	·	30b	^	31	^	32a	·	32b	^	33a	·	33b	·	33c
SP1:															-						-				-		-								-
SP2:															-						-				-		-								-
SP3:															-						-				-		-								-
SP4:															-						-				-		-
SP5:

ECgene alternative splicing isoforms for GSN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCGGTCA

About this image

GSN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Selective marker (cell-identifying gene)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Choroid Plexus

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Limb

Forelimb Myotome

Limb Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See GSN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSN

SOURCE GeneReport for Unigene cluster: Hs.522373

UniProtKB/Swiss-Prot: GELS_HUMAN, P06396

Tissue specificity: Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells

SABiosciences Expression via Pathway-Focused PCR Arrays including GSN:

Cytoskeleton Regulators in human mouse rat

Neurotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat GSN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSN gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	GSN¹	gelsolin	72.53(n) 79.1(a)	395774 NM_204934.1 NP_990265.1
African clawed frog (Xenopus laevis)	Amphibia	LOC397895²	gelsolin (AA=417)	78.41(n)	M36652.1
zebrafish (Danio rerio)	Actinopterygii	AF175294.1²	--	75.8(n)	323285 AF175294.1
fruit fly (Drosophila melanogaster)	Insecta	Gel³	actin binding	37(a)	82A1 --
worm (Caenorhabditis elegans)	Secernentea	K06A4.3³	gelsolin	38(a)	V(9499695-9501863) --
thale cress (Arabidopsis thaliana)	eudicotyledons	VLN4¹	villin 4	46.93(n) 36.67(a)	829139 NM_001203940.1 NP_001190869.1
rice (Oryza sativa)	Liliopsida	Os06g0659300¹	hypothetical protein	45.96(n) 37.57(a)	4341731 NM_001064798.1 NP_001058263.1

ENSEMBL Gene Tree for GSN (if available)
TreeFam Gene Tree for GSN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GSN gene

SVIL² FLII² AVIL² VILL² SCIN² VIL1² CAPG²

7 SIMAP similar genes for GSN using alignment to 7 protein entries: GELS_HUMAN (see all proteins):

DKFZp313L0718 SCIN CAPG AVIL VIL1 VILL

FLII

GSN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121909715^1,2	C	pathogenic	94678501(+)	`ATGGCA/G/TACTGC`	27	N D Y	mis¹		0	--	--	--	--
rs56907206^1,2		--	93646874(+)	`GCATGA/GGGCAT`	7	--	us2k¹		0	--	--	--	--
rs111529327^1,2		--	93648374(+)	`GTCCTG/ATCTCG`	7	--	int¹		1		CSA	2
rs10985195^1,2	H	--	93648911(+)	`AACCCC/TTTCTC`	7	--	int¹ trp³		4		NS EA	414
rs73660426^1,2	C,	--	93649102(+)	`TCTGCG/CCAGAC`	7	--	int¹		1		WA	2
rs73660427^1,2	C,	--	93651569(+)	`GCTGAC/ATAACA`	7	--	int¹		1		WA	2
rs116412307^1,2	C,F,	--	93651595(+)	`GGCTAT/CTGGGT`	7	--	int¹		1		WA	118
rs77475717^1,2		--	93651956(+)	`CTGGTA/C/TCCCCC`	7	--	int¹		1		NA	2
rs73660428^1,2	C,	--	93652703(+)	`GATTTG/CTTGAT`	7	--	int¹		2		WA	120
rs12006064^1,2	C,F,H,	--	93652852(+)	`TTTTAC/TAGATG`	7	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for GSN (123970075 - 124095121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GSN: --
Human Gene Mutation Database (HGMD): GSN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSN

DNA2.0 Custom Variant and Variant Library Synthesis for GSN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GSN for disorders           About GeneDecksing

OMIM gene information: 137350
OMIM disorders: 105120
UniProtKB/Swiss-Prot: GELS_HUMAN, P06396

Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis

Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically

characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal

organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid

cardiomyopathy, and nephrotic syndrome leading to renal failure

20/83 diseases for GSN (see all 83): About MalaCards

amyloidosis lattice corneal dystrophy lattice corneal dystrophy type ii finnish type amyloidosis

corneal dystrophy wiskott-aldrich syndrome cutis laxa familial mediterranean fever

inclusion body myositis cerebral amyloid angiopathy amyloidosis corneal renal clear cell carcinoma

amyloid neuropathy sensorineural hearing loss facial paralysis blepharochalasis

bladder transitional cell carcinoma autonomic dysfunction myofibrillar myopathy hearing loss

5 diseases from the University of Copenhagen DISEASES database for GSN:

Amyloidosis Corneal dystrophy Cutis laxa Polyneuropathy

Blepharochalasis

10/68 Novoseek disease relationships for GSN gene (see all 68) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
finnish type amyloidosis	94.8	15	2162627 (2), 7672107 (1), 11226199 (1), 8243656 (1) (see all 12)
amyloidosis familial	94.4	37	7683843 (2), 8395367 (2), 2162627 (2), 1315488 (1) (see all 32)
lattice corneal dystrophy	89.5	12	19832730 (2), 10767822 (1), 8110676 (1), 7683843 (1) (see all 7)
amyloidosis hereditary	80.6	8	1849145 (3), 2176164 (2), 11849445 (1), 20376775 (1) (see all 5)
amyloidosis	74.3	75	19440061 (4), 19701715 (4), 19842787 (3), 17453628 (3) (see all 31)
type iv familial amyloid polyneuropathy	73.9	1	2176550 (1)
neuropathies cranial	69.1	1	10767822 (1)
amyloid neuropathies	66.9	3	8599717 (1), 8388189 (1), 12766975 (1)
familial amyloid polyneuropathies	64.2	5	1848334 (2), 16870032 (1), 8293178 (1), 14639586 (1)
amyloidosis systemic	61.4	1	11401442 (1)

Human Genome Epidemiology (HuGE) Navigator: GSN (1 document)

Export disorders for GSN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GSN gene, integrated from 9 sources (see all 535):
(articles sorted by number of sources associating them with GSN)

Utopia: connect your pdf to the dynamic
world of online information

Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach. (PubMed id 10210201)^{1, 2, 9} De Corte V....Vandekerckhove J. (1999)
Functional consequences of disulfide bond formation in gelsolin. (PubMed id 9003812)^{1, 2, 9} Allen P.G. (1997)
Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles. (PubMed id 8599675)^{1, 2, 9} Xian W.... Braunlin W.H. (1995)
Structure of gelsolin segment 1-actin complex and the mechanism of filament severing. (PubMed id 8395021)^{1, 2, 9} McLaughlin P.J.... Weeds A.G. (1993)
Gelsolin-derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187. (PubMed id 1338910)^{1, 2, 9} de la Chapelle A.... Kere J. (1992)
Finnish type of familial amyloidosis: cosegregation of Asp187----Asn mutation of gelsolin with the disease in three large families. (PubMed id 1652889)^{1, 3, 9} Hiltunen T....Peltonen L. (1991)
Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type. (PubMed id 2176481)^{1, 2, 9} Ghiso J.... Frangione B. (1990)
Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein. (PubMed id 2157434)^{1, 2, 9} Haltia M....Frangione B. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2934	HGNC: 4620	AceView: GSN	Ensembl:ENSG00000148180	euGenes: HUgn2934
ECgene: GSN	Kegg: 2934	H-InvDB: GSN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GSN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GSN	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GSN
Wikipedia	http://en.wikipedia.org/wiki/Gelsolin

Intellectual Property for GSN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GSN gene:
Search GeneIP for patents involving GSN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of GSN
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for GSN		OriGene shRNA RFP for GSN
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSN		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSN
	OriGene Protein Over-expression Lysate for GSN		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for GSN		OriGene 3'-UTR Clone for GSN
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSN		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSN
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for GSN		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GSN		OriGene Custom Protein Services for GSN
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSN
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSN
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSN
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSN

	GenScript Custom Purified and Recombinant Proteins Services for GSN		GenScript cDNA clones with any tag delivered in your preferred vector for GSN
	GenScript Custom Assay Services for GSN		GenScript Custom Superior Antibodies Services for GSN
	GenScript Custom overexpressing Cell Line Services for GSN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for GSN (gelsolin)

	Regulatory tfbs in GSN promoter
	Search Chromatin IP Primers for GSN
	RT² qPCR Primer Assay in human, mouse, rat GSN
	GNC Network for GSN
	SABiosciences PCR Arrays including human, mouse, rat GSN

Search Tocris compounds for GSN

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	GSN antibodies
	GSN proteins
	GSN lysates

	Antibodies for GSN
	See all of Abcam's Antibodies, Kits and Proteins for GSN
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for GSN

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSN

	SwitchGear 3'UTR luciferase reporter plasmids for GSN
	SwitchGear Promoter luciferase reporter plasmids for GSN

ThermoFisher Antibodies for GSN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSN

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GSN gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

GSN Gene

gelsolin

Aliases
for GSN gene

Summaries
for GSN gene

Genomic Views
for GSN gene

Proteins
for GSN gene

Protein Domains /
Families
for GSN gene

Function
for GSN gene

Pathways & Interactions
for GSN gene

Drugs & Compounds
for GSN gene

Transcripts
for GSN gene

Expression
for GSN gene

Orthologs
for GSN gene

Paralogs
for GSN gene

Genomic Variants
for GSN gene

Disorders / Diseases
for GSN gene

Publications
for GSN gene

External Searches for GSN gene

Genome Databases showing GSN gene

Other Databases showing GSN gene

Specialized Databases showing GSN gene

Intellectual Property
for GSN gene

Products
for GSN gene

View Random Gene

Wiskott-Aldrich Syndrome
Renal Cancer
Amyloidosis Familial
sepsis
Amyloid Neuropathies
Cystic Fibrosis
Cutis Laxa
CORNEAL DYSTROPHY, LATTICE TYPE I
Polyneuropathy
Systemic Disease
Breast Cancer
CORNEAL DYSTROPHY
NSCLC
Adenocarcinoma
Asthma
Keratoconus
Amyloidosis
Cancer
premalignant
mammary tumor
Ovarian Cancer
RENAL DISEASE
Shock
Corneal Diseases
Colorectal Cancer
Inflammation
Bladder Tumors
cancer recurrence
Renal Failure
Intracerebral Hemorrhage
Neuropathies Cranial
prostate cancer
Tumors
Metastasis
Carcinoma Ductal
Necrosis
FIBROSIS IDIOPATHIC PULMONARY
renal clear cell carcinoma
Type IV Familial Amyloid Polyneuropathy
BREAST CARCINOMA
Melanoma
bladder cancer
Critically Ill
promyelocytic leukemia
Amyloid deposition
Hyperplasia
Glioma
Familial Amyloid Polyneuropathies
Tetanus
Lattice corneal dystrophy
Familial Mediterranean Fever
Carcinoma
Leukemia
Alzheimers Disease
Tuberous Sclerosis
Myopathy
Carcinoma Renal Cell
AMYLOIDOSIS, CORNEAL
Cancer Lung
HEART FAILURE
FINNISH TYPE AMYLOIDOSIS
Adenoma
Amyloidosis Hereditary
Amyloidosis Systemic
Carcinoma Squamous Cell
Atrophy
BLADDER CARCINOMA
genetic disorder

Advanced Search

Export list of displayed genes

GSN Gene

gelsolin

Aliasesfor GSN gene

Summariesfor GSN gene

Genomic Viewsfor GSN gene

Proteinsfor GSN gene

Protein Domains /Familiesfor GSN gene

Functionfor GSN gene

Pathways & Interactionsfor GSN gene

Drugs & Compoundsfor GSN gene

Transcriptsfor GSN gene

Expression for GSN gene

Orthologsfor GSN gene

Paralogsfor GSN gene

Genomic Variantsfor GSN gene

Disorders / Diseasesfor GSN gene

Publicationsfor GSN gene

External Searches for GSN gene

Genome Databases showing GSN gene

Other Databases showing GSN gene

Specialized Databases showing GSN gene

Intellectual Propertyfor GSN gene

Productsfor GSN gene

View Random Gene

Aliases
for GSN gene

Summaries
for GSN gene

Genomic Views
for GSN gene

Proteins
for GSN gene

Protein Domains /
Families
for GSN gene

Function
for GSN gene

Pathways & Interactions
for GSN gene

Drugs & Compounds
for GSN gene

Transcripts
for GSN gene

Expression
for GSN gene

Orthologs
for GSN gene

Paralogs
for GSN gene

Genomic Variants
for GSN gene

Disorders / Diseases
for GSN gene

Publications
for GSN gene

Intellectual Property
for GSN gene

Products
for GSN gene