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Aliases for GSKIP Gene

Aliases for GSKIP Gene

  • GSK3B Interacting Protein 2 3
  • C14orf129 3 4
  • Chromosome 14 Open Reading Frame 129 2
  • GSK3-Beta Interaction Protein 3
  • GSK3beta Interaction Protein 2
  • HSPC210 3

External Ids for GSKIP Gene

Previous HGNC Symbols for GSKIP Gene

  • C14orf129

Previous GeneCards Identifiers for GSKIP Gene

  • GC14P096831

Summaries for GSKIP Gene

Entrez Gene Summary for GSKIP Gene

  • This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for GSKIP Gene

GSKIP (GSK3B Interacting Protein) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSKIP Gene

Genomics for GSKIP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GSKIP Gene

96,363,452 bp from pter
96,387,290 bp from pter
23,839 bases
Plus strand

Genomic View for GSKIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSKIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSKIP Gene

No data available for Regulatory Elements for GSKIP Gene

Proteins for GSKIP Gene

  • Protein details for GSKIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GSK3-beta interaction protein
    Protein Accession:
    Secondary Accessions:
    • B3KSZ0
    • Q9BST1
    • Q9NWK0

    Protein attributes for GSKIP Gene

    139 amino acids
    Molecular mass:
    15648 Da
    Quaternary structure:
    • Interacts with GSK3B.
    • Sequence=AAF36130.1; Type=Frameshift; Positions=132; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSKIP Gene

neXtProt entry for GSKIP Gene

Proteomics data for GSKIP Gene at MOPED

Post-translational modifications for GSKIP Gene

No Post-translational modifications

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GSKIP

No data available for DME Specific Peptides for GSKIP Gene

Domains for GSKIP Gene

Protein Domains for GSKIP Gene


Suggested Antigen Peptide Sequences for GSKIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0279 family.
  • Belongs to the UPF0279 family.
genes like me logo Genes that share domains with GSKIP: view

No data available for Gene Families for GSKIP Gene

Function for GSKIP Gene

Phenotypes for GSKIP Gene

GenomeRNAi human phenotypes for GSKIP:
genes like me logo Genes that share phenotypes with GSKIP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSKIP

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GSKIP Gene

Localization for GSKIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSKIP Gene


Gene Ontology (GO) - Cellular Components for GSKIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GSKIP: view

No data available for Subcellular locations from COMPARTMENTS for GSKIP Gene

Pathways for GSKIP Gene

SuperPathways for GSKIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GSKIP Gene


No data available for Pathways by source for GSKIP Gene

Transcripts for GSKIP Gene

Unigene Clusters for GSKIP Gene

GSK3B interacting protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSKIP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSKIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: - -
SP6: - - - - - -

Relevant External Links for GSKIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSKIP Gene

mRNA expression in normal human tissues for GSKIP Gene

Protein differential expression in normal tissues for GSKIP Gene

This gene is overexpressed in Bone (17.3), Colon (7.1), and Rectum (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSKIP Gene

SOURCE GeneReport for Unigene cluster for GSKIP Gene Hs.4104

mRNA Expression by UniProt/SwissProt for GSKIP Gene

Tissue specificity: Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas.
genes like me logo Genes that share expressions with GSKIP: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for GSKIP Gene

Orthologs for GSKIP Gene

This gene was present in the common ancestor of animals.

Orthologs for GSKIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GSKIP 35
  • 89.93 (n)
  • 93.53 (a)
  • 94 (a)
(Canis familiaris)
Mammalia GSKIP 35
  • 89.54 (n)
  • 93.43 (a)
  • 93 (a)
(Mus musculus)
Mammalia Gskip 35
  • 87.77 (n)
  • 93.53 (a)
Gskip 16
Gskip 36
  • 90 (a)
(Pan troglodytes)
Mammalia C14H14orf129 35
  • 99.52 (n)
  • 100 (a)
C14H14ORF129 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Gskip 35
  • 87.77 (n)
  • 95.68 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
-- 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia GSKIP 36
  • 85 (a)
(Gallus gallus)
Aves C5H14ORF129 35
  • 75.3 (n)
  • 76.98 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia GSKIP 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gskip 35
  • 72.18 (n)
  • 73.38 (a)
Str.17150 35
(Danio rerio)
Actinopterygii gskip 35
  • 65.66 (n)
  • 71.43 (a)
wufc74a11 35
gskip 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11523 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea C06A12.3 36
  • 14 (a)
T24H7.3 36
  • 28 (a)
Y43F8B.2 36
  • 13 (a)
Species with no ortholog for GSKIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSKIP Gene

Gene Tree for GSKIP (if available)
Gene Tree for GSKIP (if available)

Paralogs for GSKIP Gene

No data available for Paralogs for GSKIP Gene

Variants for GSKIP Gene

Sequence variations from dbSNP and Humsavar for GSKIP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4006 -- 96,384,774(+) CACAT(C/T)GACCT intron-variant
rs930517 -- 96,370,227(+) TCACA(A/G)GCTTA intron-variant
rs930518 -- 96,370,492(+) GGGGC(A/G)GGGTa intron-variant
rs930519 -- 96,370,636(+) CTGCT(C/T)TCTAT intron-variant
rs962851 -- 96,366,665(+) AGGCC(A/G)GAAGG intron-variant

Relevant External Links for GSKIP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GSKIP Gene

Disorders for GSKIP Gene

No disorders were found for GSKIP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GSKIP Gene

Publications for GSKIP Gene

  1. GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta. (PMID: 16981698) Chou H.-Y. … Hong Y.-R. (Biochemistry 2006) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GSKIP Gene

Sources for GSKIP Gene

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