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GSK3B Gene

protein-coding   GIFtS: 74
GCID: GC03M119540

Glycogen Synthase Kinase 3 Beta

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycogen Synthase Kinase 3 Beta1 2     Glycogen Synthase Kinase-3 Beta2
Serine/Threonine-Protein Kinase GSK3B2 3     GSK3beta Isoform2
GSK-3 Beta2 3     EC 2.7.11.13
EC 2.7.11.263 8     EC 2.7.118

External Ids:    HGNC: 46171   Entrez Gene: 29322   Ensembl: ENSG000000827017   OMIM: 6050045   UniProtKB: P498413   

Export aliases for GSK3B gene to outside databases

Previous GC identifers: GC03M116184 GC03M119174 GC03M120822 GC03M120866 GC03M121028 GC03M116916


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GSK3B Gene:
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase
subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation.
Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show
that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for GSK3B Gene:
GSK3B (glycogen synthase kinase 3 beta) is a protein-coding gene. Diseases associated with GSK3B include neurologic diseases, and aneurysmal bone cysts. GO annotations related to this gene include protein kinase binding and identical protein binding. An important paralog of this gene is GSK3A.

UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of
glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating
and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN,
NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal
muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity
and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of
transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B
(EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with
APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation
mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby
reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC
nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin.
Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize
microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an
important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1,
inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound
repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the
NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in
pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the
anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates
MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the
establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity.
Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its
antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal
degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and
'Ser-59' and stabilizes it by protecting it from proteasomal degradation

summary for GSK3B Gene:
Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was
originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in
cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological
conditions including cancer and diabetes and is increasingly seen as an important component of neurological
diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's
disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta
are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor
trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription
factors and structural proteins, and is part of the signal transduction cascade of a large number of growth
factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt, S6K, RSK, PKA and PKC),
dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta-catenin, axin, CK1 and the
APC complex).

Gene Wiki entry for GSK3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSK3B gene promoter:
         CREB   FOXO4   deltaCREB   FOXO1a   FOXO1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSK3B promoter sequence
   Search Chromatin IP Primers for GSK3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSK3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.3

GSK3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSK3B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M119540:  view genomic region     (about GC identifiers)

Start:
119,540,170 bp from pter      End:
119,813,264 bp from pter
Size:
273,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841 (See protein sequence)
Recommended Name: Glycogen synthase kinase-3 beta  
Size: 420 amino acids; 46744 Da
Subunit: Monomer. Interacts with ARRB2, DISC1 and ZBED3 (By similarity). Interacts with CABYR, MMP2, MUC1, NIN and
PRUNE Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination
and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain). Found
in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with SGK3. Interacts with
DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA
Miscellaneous: Higher expression and activity of GSK3B are found in the skeletal muscle (vastus lateralis) of
patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been
identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350)
Selected PDB 3D structures from and Proteopedia for GSK3B (see all 55):
1GNG (3D)        1H8F (3D)        1I09 (3D)        1J1B (3D)        1J1C (3D)        1O6K (3D)    
Secondary accessions: D3DN89 Q9BWH3 Q9UL47
Alternative splicing: 2 isoforms:  P49841-1   P49841-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GSK3B: NX_P49841

Explore proteomics data for GSK3B at MOPED

Post-translational modifications: 

  • Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase
    phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by
    phosphorylation at Tyr-2161
  • Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity1
  • Ubiquitination2 at Lys205, Lys292, Lys297
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSK3B (P49841) (see all 20)
     CDFGSAK  FAESCKP  YFFYSSG  VPETVYR 


    See GSK3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139628.1  NP_002084.2  

    ENSEMBL proteins: 
     ENSP00000264235   ENSP00000324806  
    Reactome Protein details: P49841

    GSK3B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant GSK3B Protein
    R&D Systems Recombinant & Natural Proteins for GSK3B (GSK-3 beta)
    Enzo Life Sciences proteins for GSK3B
    OriGene Purified Protein for GSK3B
    OriGene Protein Over-expression Lysate for GSK3B
    OriGene MassSpec for GSK3B
    OriGene Custom Protein Services for GSK3B
    GenScript Custom Purified and Recombinant Proteins Services for GSK3B
    Novus Biologicals GSK3B Proteins
    Novus Biologicals GSK3B Lysates
    Sino Biological Recombinant Protein for GSK3B
    Sino Biological Cell Lysate for GSK3B
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    GSK3B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GSK3B
    R&D Systems Antibodies for GSK3B (GSK-3 beta)
    Cell Signaling Technology (CST) Antibodies for GSK3B 
    OriGene Antibodies for GSK3B
    OriGene Custom Antibody Services for GSK3B
    Novus Biologicals GSK3B Antibodies
    Abcam antibodies for GSK3B (P49840, P49841)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GSK3B
    LSBio Antibodies in human, mouse, rat for GSK3B

    GSK3B Assay Products:

    EMD Millipore Kits and Assays for the Analysis of GSK3B
    OriGene Custom Assay Services for GSK3B
    R&D Systems ELISAs for GSK3B (GSK-3 beta)         (see all)
    GenScript GSK3B-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for GSK3B
    Enzo Life Sciences assays for GSK3B
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: glycogen synthase kinase 3 beta
    GSK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49841

    ProtoNet protein and cluster: P49841

    UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily
    Similarity: Contains 1 protein kinase domain


    GSK3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSK3B_HUMAN, P49841
    Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of
    glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating
    and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN,
    NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal
    muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity
    and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of
    transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B
    (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with
    APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation
    mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby
    reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC
    nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin.
    Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize
    microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an
    important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1,
    inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound
    repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the
    NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in
    pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the
    anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates
    MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the
    establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity.
    Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its
    antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal
    degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and
    'Ser-59' and stabilizes it by protecting it from proteasomal degradation
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation
    at Ser-9 by PKB/AKT1 and RPS6KA3; phosphorylation at this site causes a conformational change, preventing access
    of substrates to the active site. Inhibited by lithium

         Genatlas biochemistry entry for GSK3B:
    glycogen synthase kinase 3 beta,dual specificity protein-kinase,regulating glycogen synthesis in skeletal muscle
    through Tyr activating or Ser/Thr inactivating prosphorylation,key downstream target of PI3-kinase/AKT survival
    signaling pathway and involved in the regulation of apoptosis,Drosophila Shaggy-Zeste-White 3 homolog,binding to
    APC-beta-catenin complex,

         Enzyme Numbers (IUBMB): EC 2.7.11.261 2 EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI--
    GO:0002039p53 binding IDA14744935
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
         
    GSK3B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GSK3B:
     Decreased mitotic index  Decreased substrate adherent c  Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

         15 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Gsk3b):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system  no phenotypic analysis  normal  renal/urinary system  skeleton 

    GSK3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GSK3B: Gsk3btm1Jrw Gsk3btm1Grc Gsk3btm1.2Ypc Gsk3btm1.1Atak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSK3B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSK3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSK3B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSK3B

    miRNA
    Products:
        
    miRTarBase miRNAs that target GSK3B:
    hsa-mir-877-3p (MIRT036842), hsa-mir-26a-5p (MIRT004676), hsa-mir-425-5p (MIRT039319), hsa-mir-92a-3p (MIRT049345), hsa-mir-155-5p (MIRT021044)

    Block miRNA regulation of human, mouse, rat GSK3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GSK3B (see all 171):
    hsa-miR-579 hsa-miR-100* hsa-miR-640 hsa-miR-631 hsa-miR-1245 hsa-miR-128 hsa-miR-3074-3p hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GSK3B
    Predesigned siRNA for gene silencing in human, mouse, rat GSK3B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSK3B

    Clone
    Products:
         
    OriGene clones in human, mouse for GSK3B (see all 18)
    OriGene ORF clones in mouse, rat for GSK3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GSK3B (NM_002093)
    Sino Biological Human cDNA Clone for GSK3B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSK3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSK3B

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for GSK3B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GSK3B_HUMAN, P49841: Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to
    cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated
    form to the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane5
    cytosol4
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA14744935
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    GSK3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GSK3B About   (see all 124)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39
    3Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    4Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    Translation Regulation activity of EIF20.47
    5Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for GSK3B (see all 11)
        Wnt Signaling Pathways
    IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GSK3B (see all 37)
        IL-4 Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    G12-G13 in Cellular Signaling
    p53 Signaling

    4 Cell Signaling Technology (CST) Pathways for GSK3B
        Wnt / Hedgehog / Notch
    Neuroscience
    PI3K / Akt Signaling
    Glucose / Energy Metabolism

    Selected Tocris Bioscience Pathways for GSK3B (see all 6)
        Akt Pathway
    NF-kappaB Pathway
    Hedgehog Pathway
    MAPK Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for GSK3B (see all 30)
        Signal transduction cAMP signaling
    Development EGFR signaling pathway
    Signal transduction AKT signaling
    Development Endothelin-1/EDNRA signaling
    Immune response CD28 signaling

    Selected BioSystems Pathways for GSK3B (see all 47)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Cell cycle
    Senescence and Autophagy
    Wnt Signaling Pathway

    2 Sino Biological Pathways for GSK3B
        Canonical Wnt Pathway
    NF-kB (NFkB) Pathway

    Selected Reactome Pathways for GSK3B (see all 7)
        AKT phosphorylates targets in the cytosol
    CRMPs in Sema3A signaling
    Regulation of HSF1-mediated heat shock response
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    Constitutive PI3K/AKT Signaling in Cancer


    Selected Kegg Pathways  (Kegg details for GSK3B) (see all 29):
        ErbB signaling pathway
    Chemokine signaling pathway
    Cell cycle
    PI3K-Akt signaling pathway
    Wnt signaling pathway


    GSK3B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSK3B (see all 17): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cellular Senescence in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GSK3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSK3B (P498411, 2, 3 ENSP000003248064) via UniProtKB, MINT, STRING, and/or I2D (see all 563)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPTP106361, 2, 3, ENSP000003408204EBI-373586,EBI-366182 MINT-3974171 MINT-8211409 MINT-3974216 MINT-8211419 MINT-8211397 MINT-8211467 MINT-8210275 I2D: score=4 STRING: ENSP00000340820
    BICD1Q96G011, 2, 3, ENSP000002814744EBI-373586,EBI-1104509 MINT-4051287 MINT-4049823 MINT-4049804 MINT-4049784 MINT-4049883 MINT-4049943 MINT-4049862 I2D: score=2 STRING: ENSP00000281474
    AXIN1O151691, 2, 3, ENSP000002623204EBI-373586,EBI-710484 MINT-7025816 MINT-7025684 MINT-7025707 MINT-8403910 MINT-4508259 I2D: score=7 STRING: ENSP00000262320
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-373586,EBI-491549 MINT-8403910 MINT-8398846 MINT-4508051 I2D: score=9 STRING: ENSP00000344456
    TP53P046371, 2, 3, ENSP000002693054EBI-373586,EBI-366083 MINT-4793253 MINT-8257746 MINT-4793219 I2D: score=5 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 64):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000320re-entry into mitotic cell cycle IEA--
    GO:0001837epithelial to mesenchymal transition IMP15448698
    GO:0001954positive regulation of cell-matrix adhesion IMP18156211
    GO:0005977glycogen metabolic process IDA8638126
    GO:0006349regulation of gene expression by genetic imprinting IEA--

    GSK3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GSK3B
    6 ApexBio Compounds for GSK3B     About this table
    CompoundAction CAS #
    AR-A014418Cell-permeable GSK-3beta inhibitor[487021-52-3]
    CHIR-98014selective and ATP-competitive inhibitor of GSK-3beta[252935-94-7]
    CHIR-99021 (CT99021)Cell-permeable, ATP-competitive GSK-3 inhibitor[252917-06-9]
    LY2090314potent inhibitor of glycogen synthase kinase-3[603288-22-8]
    SB 216763Potent and selective, ATP-competitive GSK-3 inhibitor[280744-09-4]
    SB 415286Potent and selective GSK-3 inhibitor[264218-23-7]

    Compounds for GSK3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIO Potent, selective GSK-3 inhibitor [667463-62-9]
    BIO-acetoximeSelective GSK-3alpha/beta inhibitor[667463-85-6]
    MeBIOInactive analog of BIO (Cat. No. 3194)[667463-95-8]
    TWS 119GSK-3beta inhibitor; induces neuronal differentiation in ESCs[601514-19-6]
    SB 216763 Potent, selective GSK-3 inhibitor [280744-09-4]

    3 HMDB Compounds for GSK3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    LithiumLi (see all 5)7439-93-2--

    Selected DrugBank Compounds for GSK3B (see all 20)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione-- --target--17139284 17016423 10592235
    Alsterpaullone-- --target--17139284 17016423 10592235
    I-5-- --target--17139284 17016423 10592235
    Indirubin-3'-Monoxime-- --target--17139284 17016423 10592235
    Lithium-- 7439-93-2targetinhibitor17628506 16733521 19754466
    N-(4-Methoxybenzyl)-N'-(5-Nitro-1,3-Thiazol-2-Yl)Urea-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423
    Staurosporine-- 62996-74-1target--17139284 17016423
    (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for GSK3B gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 91.9 279 14985354 (6), 19642201 (5), 8809831 (4), 15661493 (3) (see all 99)
    sb-216763 73.5 1 18417075 (1)
    lithium 67 51 11579131 (6), 19442155 (4), 12787068 (3), 18932008 (3) (see all 17)
    lithium chloride 60.7 5 12794074 (1), 15178691 (1), 11035789 (1)
    threonine 57.3 21 10076565 (2), 12787068 (1), 18547980 (1), 18851699 (1) (see all 14)
    serine 47.9 22 10076565 (2), 12787068 (1), 18547980 (1), 11956818 (1) (see all 14)
    phosphatidylinositol 41.9 15 10954722 (5), 16055672 (1), 15062551 (1), 12584189 (1) (see all 6)
    valproate 41.4 4 11579131 (1), 12787068 (1), 15121343 (1), 12504922 (1)
    valproic acid 29.2 2 18240065 (1)
    inositol 21.1 7 19442155 (3)

    3 PharmGKB related drug/compound annotations for GSK3B gene    About this table
    Drug/compound PharmGKB Annotation
    citalopramCA  
    fluoxetineCA  
    lithiumCA  



    GSK3B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for GSK3B gene (2 alternative transcripts): 
    NM_001146156.1  NM_002093.3  

    Unigene Cluster for GSK3B:

    Glycogen synthase kinase 3 beta
    Hs.445733  [show with all ESTs]
    Unigene Representative Sequence: NM_002093
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264235(uc003edm.3 uc003edn.3 uc003edo.3) ENST00000316626
    ENST00000474830 ENST00000473886

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GSK3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GSK3B (see all 171):
    hsa-miR-579 hsa-miR-100* hsa-miR-640 hsa-miR-631 hsa-miR-1245 hsa-miR-128 hsa-miR-3074-3p hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GSK3B
    Predesigned siRNA for gene silencing in human, mouse, rat GSK3B
    Clone
    Products:
         
    OriGene clones in human, mouse for GSK3B (see all 18)
    OriGene ORF clones in mouse, rat for GSK3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GSK3B (NM_002093)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSK3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSK3B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GSK3B
    OriGene qSTAR qPCR primer pairs in human, mouse for GSK3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSK3B
      QuantiTect SYBR Green Assays in human, mouse, rat GSK3B
      QuantiFast Probe-based Assays in human, mouse, rat GSK3B

    Additional mRNA sequence: 

    AB451356.1 AK290897.1 AY123976.1 BC000251.1 BC012760.2 BX640779.1 CR536510.1 EU302497.1 
    L33801.1 

    13 DOTS entries:

    DT.95158463  DT.75162342  DT.100814329  DT.102828961  DT.307506  DT.97833687  DT.91746688  DT.91918846 
    DT.92030498  DT.92419358  DT.95366430  DT.100682142  DT.100773350 

    Selected AceView cDNA sequences (see all 218):

    CR615239 AA495996 AA312353 AA351029 CR536510 N20039 AA778906 F04515 
    BU194539 BF056411 BM703312 AA911658 AW959406 AI160379 BM471863 BX091271 
    AA291353 NM_002093 Z43594 Z39659 AW198237 AY123976 CB242301 BX403207 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GSK3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGGATTCA
    GSK3B Expression
    About this image


    GSK3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    GSK3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSK3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445733

    UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841
    Tissue specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and
    kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSK3B (see all 17): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Cellular Senescence in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GSK3B
    OriGene qSTAR qPCR primer pairs in human, mouse for GSK3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSK3B
    QuantiTect SYBR Green Assays in human, mouse, rat GSK3B
    QuantiFast Probe-based Assays in human, mouse, rat GSK3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GSK3B gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsk3b1 , 5 glycogen synthase kinase 3 beta1, 5 92.73(n)1
    99.02(a)1
      16 (26.54 cM)5
    566371  NM_019827.61  NP_062801.11 
     380890015 
    chicken
    (Gallus gallus)
    Aves GSK3B1 glycogen synthase kinase 3 beta 88.52(n)
    97.39(a)
      418335  XM_416557.4  XP_416557.4 
    lizard
    (Anolis carolinensis)
    Reptilia GSK3B6
    glycogen synthase kinase 3 beta
    92(a)
    1 ↔ 1
    GL343414.1(302380-423848)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xgsk-32 intracellular kinase 77.89(n)    L38492.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gsk3b2 glycogen synthase kinase 3 beta 78.1(n)   30654  AJ223502.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sgg3 circadian rhythm protein
    serine/threonine kinase
    75(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y18D10A.53
    gsk-31
    Eukaryotic protein kinase domain3
    gsk-31
    74(a)
    (best of 6)3
    64.84(n)1
    77.74(a)1
      I(12827414-12832717)3
    1731491  NM_060842.51  NP_493243.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RIM11(YMR139W)4 Protein kinase required for signal transduction during more   --   13(546125-547237) 855170  NP_013859.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SK131 SK13 63.58(n)
    68.12(a)
      831316  NM_121468.3  NP_196968.2 
    rice
    (Oryza sativa)
    Liliopsida NM_188342.12   -- 73.01(n)    NM_188342.1 


    ENSEMBL Gene Tree for GSK3B (if available)
    TreeFam Gene Tree for GSK3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GSK3B gene
    GSK3A2  ENSG000002686432  
    Selected SIMAP similar genes for GSK3B using alignment to 4 protein entries:     GSK3B_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D0638    GSK3A    CDK3    DKFZp686O0215    MAK    CDKL2
    CDK2    CDK1    CDK7    MAPK13    CDK20    CDKL4
    CDKL5    CDK6    MAPK1    MAPK11    MAPK3    CDK5

    GSK3B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GSK3B
    PGOHUM00000238681


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GSK3B (see all 5177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500210491,2
    C--116932533(+) TTCAC-/ATATAT
            
    ATATA
    2 -- int10--------
    rs355732141,2
    C--116932559(+) ATATA-/AT/A  
      TAT
    /TA
    TTTCA
    2 -- int11NA 2
    rs754039381,2
    F--116938346(+) AAAGAG/CACTTA 2 -- int12Minor allele frequency- C:0.50NA 4
    rs794918521,2
    F--116938351(+) ACTTAG/CACTCC 2 -- int12Minor allele frequency- C:0.50NA 4
    rs681027081,2
    C--116960115(+) TATATA/TTTTTT 2 -- int12Minor allele frequency- T:0.00NA 4
    rs23194001,2
    C,A--117012295(+) TTTTTA/GAAAAA 2 -- int1 trp33Minor allele frequency- G:0.38NA EA 242
    rs1411066951,2
    C--117019113(+) CACGC-/AGAGAGA 2 -- int10--------
    rs2010379341,2
    C--117035584(+) ACTAA-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs1914958411,2
    --117046525(+) CATTAA/TAAAAA 2 -- int10--------
    rs785650631,2
    C--117047858(+) CAAAT-/ATAAC 
            
    ATGAG
    2 -- int10--------

    HapMap Linkage Disequilibrium report for GSK3B (119540170 - 119790170 bp, first 250kb of GSK3B)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for GSK3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666502CNV Deletion23128226
    esv2516850CNV Deletion19546169
    esv2631534CNV Deletion19546169
    dgv883e199CNV Deletion23128226
    nsv507120CNV Insertion20534489
    esv22981CNV Loss19812545
    nsv829697CNV Loss17160897
    nsv3964CNV Loss18451855
    nsv829696CNV Gain17160897
    nsv482988CNV Complex15286789

    Human Gene Mutation Database (HGMD): GSK3B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSK3B
    DNA2.0 Custom Variant and Variant Library Synthesis for GSK3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605004    OMIM disorders: --

    Selected diseases for GSK3B (see all 86):    
    About MalaCards
    neurologic diseases    aneurysmal bone cysts    waardenburg syndrome type 2    waardenburg's syndrome
    alzheimer's disease    parathyroid carcinoma    leopard syndrome    myoclonus epilepsy
    parkinson's disease    myoclonus    progressive myoclonus epilepsy    severe congenital neutropenia
    tardive dyskinesia    bipolar disorder    usher syndrome    corneal dystrophy
    toxic encephalopathy    frontotemporal dementia    brain disease    familial adenomatous polyposis

    4 diseases from the University of Copenhagen DISEASES database for GSK3B:
    Alzheimer's disease     Usher syndrome     Cancer     Toxic encephalopathy

    GSK3B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for GSK3B gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paired helical filament 74.7 1 7686508 (1)
    familial adenomatous polyposis 67.3 12 10477752 (1), 12213737 (1), 12771132 (1), 10549354 (1) (see all 11)
    neurofibrillary tangles 58 4 10754226 (1), 18932008 (1)
    alzheimers disease 56.7 25 18932008 (3), 11805297 (2), 11881998 (2), 11013232 (2) (see all 13)
    late onset alzheimer disease 52.4 1 11326302 (1)
    bipolar disorder 50.1 9 16289845 (4), 17628506 (1), 14729229 (1), 19442155 (1)
    brain diseases 33.3 1 7758758 (1)
    senile plaques 29.5 2 18932008 (1)
    neurodegeneration 26.9 4 8809831 (1), 19642201 (1), 10509176 (1)
    insulin resistance 19.9 1 11520307 (1)

    Genetic Association Database (GAD): GSK3B
    Human Genome Epidemiology (HuGE) Navigator: GSK3B (67 documents)

    Export disorders for GSK3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GSK3B gene, integrated from 10 sources (see all 942):
    (articles sorted by number of sources associating them with GSK3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter. (PubMed id 10486203)1, 2, 3 Lau K.F.... Shaw P.C. (Genomics 1999)
    2. Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease. (PubMed id 18991351)1, 4, 9 Kwok J.B....Schofield P.R. (Ann. Neurol. 2008)
    3. No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population. (PubMed id 16289845)1, 4, 9 Lee K.Y....Kim Y.S. (Neurosci. Lett. 2006)
    4. GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. (PubMed id 16315267)1, 4, 9 Kwok J.B....Schofield P.R. (Ann. Neurol. 2005)
    5. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. (PubMed id 11440715)1, 2, 9 Dajani R....Pearl L.H. (Cell 2001)
    6. No significant association between the genetic polymorphisms in the GSK-3 beta gene and schizophrenia in the Chinese population. (PubMed id 17368486)1, 4, 9 Meng J....He L. (J Psychiatr Res 2008)
    7. No association of GSK3beta gene (GSK3B) with Japanese schizophrenia. (PubMed id 15719395)1, 4, 9 Ikeda M....Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005)
    8. Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome. (PubMed id 17270183)1, 4, 9 Goodarzi M.O....Azziz R. (Fertil. Steril. 2007)
    9. Human dynamin-like protein interacts with the glycogen synthase kinase 3beta. (PubMed id 9731200)1, 2, 9 Hong Y.-R.... Chow C.-C. (Biochem. Biophys. Res. Commun. 1998)
    10. Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. (PubMed id 7980435)1, 2, 9 Stambolic V. and Woodgett J.R. (Biochem. J. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2932 HGNC: 4617 AceView: GSK3B Ensembl:ENSG00000082701 euGenes: HUgn2932
    ECgene: GSK3B Kegg: 2932 H-InvDB: GSK3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GSK3B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSK3B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GSK3B gene:
    Search GeneIP for patents involving GSK3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of GSK3B
     EMD Millipore Purified and/or Recombinant GSK3B Protein
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     Antibodies for GSK3B (GSK-3 beta)   Browse Cell Culture Products  
     ELISAs for GSK3B (GSK-3 beta)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
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     Recombinant/Natural Proteins for GSK3B (GSK-3 beta)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for GSK3B (GSK-3 beta)  
     OriGene Antibodies for GSK3B   OriGene RNAi products in human, mouse, rat for GSK3B  
     OriGene qPCR primer pairs and template standards for GSK3B   OriGene Protein Over-expression Lysate for GSK3B  
     OriGene MassSpec something-or-other for GSK3B   OriGene clones in human, mouse for GSK3B  
     OriGene qSTAR qPCR primer pairs in human, mouse for GSK3B   OriGene Purified Protein for GSK3B  
     OriGene ORF clones in mouse, rat for GSK3B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GSK3B   OriGene Custom Protein Services for GSK3B  

     
     
     Block miRNA regulation of human, mouse, rat GSK3B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GSK3B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSK3B Predesigned siRNA for gene silencing in human, mouse, rat GSK3B
     QuantiFast Probe-based Assays in human, mouse, rat GSK3B QuantiTect SYBR Green Assays in human, mouse, rat GSK3B
     PCR Arrays including human, mouse, rat GSK3B Search Chromatin IP Primers for GSK3B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSK3B  GeneGlobe Interaction Network for GSK3B
     Regulatory tfbs in GSK3B promoter
     GenScript Custom Purified and Recombinant Proteins Services for GSK3B GenScript cDNA clones with any tag delivered in your preferred vector for GSK3B
     GenScript GSK3B-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for GSK3B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for GSK3B 

     Tocris compounds for GSK3B
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     Cell Lysates for GSK3B
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     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Drugs/Proteins for GSK3B
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Antibodies for GSK3B
     See all of Abcam's Antibodies, Kits and Proteins for GSK3B
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GSK3B
     Gene Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GSK3B
     SwitchGear Promoter luciferase reporter plasmids for GSK3B
     ThermoFisher Antibody for GSK3B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSK3B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GSK3B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GSK3B
     LSBio Antibodies in human, mouse, rat for GSK3B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for GSK3B
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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