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Aliases for GSK3B Gene

Aliases for GSK3B Gene

  • Glycogen Synthase Kinase 3 Beta 2 3
  • EC 2.7.11.26 4 63
  • Serine/Threonine-Protein Kinase GSK3B 4
  • EC 2.7.11.1 4
  • GSK-3 Beta 4
  • EC 2.7.11 63

External Ids for GSK3B Gene

Summaries for GSK3B Gene

Entrez Gene Summary for GSK3B Gene

  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for GSK3B Gene

GSK3B (Glycogen Synthase Kinase 3 Beta) is a Protein Coding gene. Diseases associated with GSK3B include aneurysmal bone cysts and waardenburg's syndrome. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is GSK3A.

UniProtKB/Swiss-Prot for GSK3B Gene

  • Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on Thr-548, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at Thr-182, leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at Thr-687 upon T-cell activation. Phosphorylates NR1D1 st Ser-55 and Ser-59 and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT Ser-427 and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at Ser-17 and Ser-21 and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at Ser-3 or Ser-4 which positively regulates its activity.

Tocris Summary for GSK3B Gene

  • Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimers disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt, S6K, RSK, PKA and PKC), dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta-catenin, axin, CK1 and the APC complex).

Gene Wiki entry for GSK3B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSK3B Gene

Genomics for GSK3B Gene

Genomic Location for GSK3B Gene

Start:
119,821,321 bp from pter
End:
120,094,417 bp from pter
Size:
273,097 bases
Orientation:
Minus strand

Genomic View for GSK3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSK3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSK3B Gene

Regulatory Elements for GSK3B Gene

Proteins for GSK3B Gene

  • Protein details for GSK3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49841-GSK3B_HUMAN
    Recommended name:
    Glycogen synthase kinase-3 beta
    Protein Accession:
    P49841
    Secondary Accessions:
    • D3DN89
    • Q9BWH3
    • Q9UL47

    Protein attributes for GSK3B Gene

    Size:
    420 amino acids
    Molecular mass:
    46744 Da
    Quaternary structure:
    • Monomer. Interacts with ARRB2, DISC1 and ZBED3 (By similarity). Interacts with CABYR, MMP2, MUC1, NIN and PRUNE Interacts with AXIN1; the interaction mediates hyperphosphorylation of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with SGK3. Interacts with DAB2IP (via C2 domain); the interaction stimulates GSK3B kinase activation. Interacts (via C2 domain) with PPP2CA. Interacts with the CLOCK-ARNTL/BMAL1 heterodimer. Interacts with the ARNTL/BMAL1.
    Miscellaneous:
    • Higher expression and activity of GSK3B are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350).

    Three dimensional structures from OCA and Proteopedia for GSK3B Gene

    Alternative splice isoforms for GSK3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSK3B Gene

Proteomics data for GSK3B Gene at MOPED

Post-translational modifications for GSK3B Gene

  • Mono-ADP-ribosylation by PARP10 negatively regulates kinase activity
  • Phosphorylated by AKT1 and ILK1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys205, Lys292, and Lys297

Other Protein References for GSK3B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for GSK3B Gene

Gene Families for GSK3B Gene

Graphical View of Domain Structure for InterPro Entry

P49841

UniProtKB/Swiss-Prot:

GSK3B_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P49841
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.:
    • P49841
genes like me logo Genes that share domains with GSK3B: view

Function for GSK3B Gene

Molecular function for GSK3B Gene

GENATLAS Biochemistry: glycogen synthase kinase 3 beta,dual specificity protein-kinase,regulating glycogen synthesis in skeletal muscle through Tyr activating or Ser/Thr inactivating prosphorylation,key downstream target of PI3-kinase/AKT survival signaling pathway and involved in the regulation of apoptosis,Drosophila Shaggy-Zeste-White 3 homolog,binding to APC-beta-catenin complex,
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [tau protein] = ADP + [tau protein] phosphate
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation at Tyr-216. In response to insulin, inhibited by phosphorylation at Ser-9 by PKB/AKT1 and RPS6KA3; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.
UniProtKB/Swiss-Prot Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on Thr-548, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at Thr-182, leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at Thr-687 upon T-cell activation. Phosphorylates NR1D1 st Ser-55 and Ser-59 and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT Ser-427 and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at Ser-17 and Ser-21 and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at Ser-3 or Ser-4 which positively regulates its activity.

Enzyme Numbers (IUBMB) for GSK3B Gene

Gene Ontology (GO) - Molecular Function for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 20864106
GO:0002039 p53 binding IDA 14744935
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with GSK3B: view
genes like me logo Genes that share phenotypes with GSK3B: view

Animal Models for GSK3B Gene

MGI Knock Outs for GSK3B:

No data available for Transcription Factor Targeting and HOMER Transcription for GSK3B Gene

Localization for GSK3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSK3B Gene

Cytoplasm. Nucleus. Cell membrane. Note=The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSK3B Gene COMPARTMENTS Subcellular localization image for GSK3B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 4
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 14744935
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GSK3B: view

Pathways for GSK3B Gene

SuperPathways for GSK3B Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 IL-9 Signaling Pathways
4 Translation Insulin regulation of translation
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with GSK3B: view

Pathways by source for GSK3B Gene

Gene Ontology (GO) - Biological Process for GSK3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001837 epithelial to mesenchymal transition IMP 15448698
GO:0001954 positive regulation of cell-matrix adhesion IMP 18156211
GO:0005977 glycogen metabolic process IDA 8638126
GO:0006349 regulation of gene expression by genetic imprinting IEA --
genes like me logo Genes that share ontologies with GSK3B: view

Compounds for GSK3B Gene

(6) ApexBio Compounds for GSK3B Gene

Compound Action Cas Number
AR-A014418 Cell-permeable GSK-3beta inhibitor [487021-52-3]
CHIR-98014 selective and ATP-competitive inhibitor of GSK-3beta. [252935-94-7]
CHIR-99021 (CT99021) Cell-permeable, ATP-competitive GSK-3 inhibitor [252917-06-9]
LY2090314 potent inhibitor of glycogen synthase kinase-3 [603288-22-8]
SB 216763 Potent and selective, ATP-competitive GSK-3 inhibitor. [280744-09-4]
SB 415286 Potent and selective GSK-3 inhibitor. [264218-23-7]

(5) Tocris Compounds for GSK3B Gene

Compound Action Cas Number
BIO Potent, selective GSK-3 inhibitor [667463-62-9]
BIO-acetoxime Selective GSK-3alpha/beta inhibitor [667463-85-6]
MeBIO Inactive analog of BIO (Cat. No. 3194) [667463-95-8]
SB 216763 Potent, selective GSK-3 inhibitor [280744-09-4]
TWS 119 GSK-3beta inhibitor; induces neuronal differentiation in ESCs [601514-19-6]

(3) HMDB Compounds for GSK3B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Lithium
  • Li
7439-93-2

(20) Novoseek inferred chemical compound relationships for GSK3B Gene

Compound -log(P) Hits PubMed IDs
glycogen 91.9 142
sb-216763 73.5 1
lithium 67 34
lithium chloride 60.7 3
threonine 57.3 15

(3) PharmGKB related drug/compound annotations for GSK3B Gene

Drug/compound Annotation
citalopram CA
fluoxetine CA
lithium CA
genes like me logo Genes that share compounds with GSK3B: view

Transcripts for GSK3B Gene

Unigene Clusters for GSK3B Gene

Glycogen synthase kinase 3 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSK3B Gene

No ASD Table

Relevant External Links for GSK3B Gene

GeneLoc Exon Structure for
GSK3B
ECgene alternative splicing isoforms for
GSK3B

Expression for GSK3B Gene

mRNA expression in normal human tissues for GSK3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSK3B Gene

SOURCE GeneReport for Unigene cluster for GSK3B Gene Hs.445733

mRNA Expression by UniProt/SwissProt for GSK3B Gene

P49841-GSK3B_HUMAN
Tissue specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
genes like me logo Genes that share expressions with GSK3B: view

No data available for mRNA differential expression in normal tissues for GSK3B Gene

Orthologs for GSK3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GSK3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSK3B 35
  • 98.46 (n)
  • 98.15 (a)
GSK3B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GSK3B 35
  • 96.37 (n)
  • 99.07 (a)
GSK3B 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSK3B 35
  • 97 (n)
  • 99.77 (a)
GSK3B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsk3b 35
  • 92.73 (n)
  • 99.02 (a)
Gsk3b 16
Gsk3b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GSK3B 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSK3B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsk3b 35
  • 92.4 (n)
  • 99.02 (a)
chicken
(Gallus gallus)
Aves GSK3B 35
  • 88.52 (n)
  • 97.39 (a)
GSK3B 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSK3B 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xgsk-3 35
tropical clawed frog
(Silurana tropicalis)
Amphibia gsk3b 35
  • 77.09 (n)
  • 91.28 (a)
Str.19775 35
zebrafish
(Danio rerio)
Actinopterygii gsk3b 35
  • 79.82 (n)
  • 95.59 (a)
gsk3b 36
  • 94 (a)
OneToMany
GSK3B (2 of 2) 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gskt 36
  • 49 (a)
ManyToMany
sgg 36
  • 26 (a)
ManyToMany
sgg 37
  • 75 (a)
Pk34A 37
  • 39 (a)
gskt 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea gsk-3 35
  • 64.84 (n)
  • 77.74 (a)
gsk-3 36
  • 72 (a)
OneToMany
C44H4.6 37
  • 42 (a)
Y18D10A.5 37
  • 74 (a)
Y106G6D.4 37
  • 31 (a)
F21F3.2 37
  • 32 (a)
R03D7.5 37
  • 38 (a)
C36B1.10 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRK1 36
  • 35 (a)
ManyToMany
RIM11 36
  • 48 (a)
ManyToMany
RIM11 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7461 35
thale cress
(Arabidopsis thaliana)
eudicotyledons SK13 35
  • 63.58 (n)
  • 68.12 (a)
corn
(Zea mays)
Liliopsida Zm.6802 35
rice
(Oryza sativa)
Liliopsida Os05g0134000 35
  • 61.67 (n)
  • 68.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
OneToMany
Species with no ortholog for GSK3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSK3B Gene

ENSEMBL:
Gene Tree for GSK3B (if available)
TreeFam:
Gene Tree for GSK3B (if available)

Paralogs for GSK3B Gene

Paralogs for GSK3B Gene

Pseudogenes.org Pseudogenes for GSK3B Gene

genes like me logo Genes that share paralogs with GSK3B: view

Variants for GSK3B Gene

Sequence variations from dbSNP and Humsavar for GSK3B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs182839 -- 120,071,347(-) TATAT(A/G)GGATA intron-variant
rs334533 -- 120,074,035(-) gagca(A/G)cggca intron-variant
rs334534 -- 120,073,762(-) acaga(A/G)cctta intron-variant
rs334535 -- 120,073,457(-) GGTAA(A/G)AAGTG intron-variant
rs334536 -- 120,071,865(-) GGTTC(G/T)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSK3B Gene

Variant ID Type Subtype PubMed ID
nsv482988 CNV Complex 15286789
nsv507120 CNV Insertion 20534489
nsv829696 CNV Gain 17160897
esv2516850 CNV Deletion 19546169
dgv883e199 CNV Deletion 23128226
esv22981 CNV Loss 19812545
esv2631534 CNV Deletion 19546169
nsv3964 CNV Loss 18451855
esv2666502 CNV Deletion 23128226
nsv829697 CNV Loss 17160897

Relevant External Links for GSK3B Gene

HapMap Linkage Disequilibrium report
GSK3B
Human Gene Mutation Database (HGMD)
GSK3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSK3B Gene

Disorders for GSK3B Gene

(4) University of Copenhagen DISEASES for GSK3B Gene

(24) Novoseek inferred disease relationships for GSK3B Gene

Disease -log(P) Hits PubMed IDs
paired helical filament 74.7 1
familial adenomatous polyposis 67.3 11
neurofibrillary tangles 58 2
alzheimers disease 56.7 18
late onset alzheimer disease 52.4 1

Relevant External Links for GSK3B

Genetic Association Database (GAD)
GSK3B
Human Genome Epidemiology (HuGE) Navigator
GSK3B
genes like me logo Genes that share disorders with GSK3B: view

No data available for UniProtKB/Swiss-Prot for GSK3B Gene

Publications for GSK3B Gene

  1. Human dynamin-like protein interacts with the glycogen synthase kinase 3beta. (PMID: 9731200) Hong Y.-R. … Chow C.-C. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  2. Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. (PMID: 7980435) Stambolic V. … Woodgett J.R. (Biochem. J. 1994) 3 4 23
  3. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. (PMID: 11440715) Dajani R. … Pearl L.H. (Cell 2001) 3 4 23
  4. A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder. (PMID: 14729229) Benedetti F. … Smeraldi E. (Neurosci. Lett. 2004) 3 23 48
  5. A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. (PMID: 15351432) Benedetti F. … Smeraldi E. (Neurosci. Lett. 2004) 3 23 48

Products for GSK3B Gene

  • Addgene plasmids for GSK3B

Sources for GSK3B Gene

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