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GSK3B Gene

protein-coding GIFtS: 72

GC03M121028

glycogen synthase kinase 3 beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.26 ^³

Descriptions
GSK-3 beta ^³
GSK3beta isoform ^²
glycogen synthase kinase 3 beta ^²
glycogen synthase kinase-3 beta ^²

External Ids
HGNC: 4617¹
Entrez Gene: 2932²
UniProtKB: P49841³
Ensembl: ENSG00000082701⁷

Search outside databases for aliases for GSK3B gene

Previous GC identifers: GC03M116184 GC03M119174 GC03M120822 GC03M120866

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GSK3B:

Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially

identified as a phosphorylating and inactivating glycogen synthase (see GYS1, MIM 138570). Two

isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic

and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell

development, and body pattern formation (Plyte et al., 1992 [PubMed 1333807]).[supplied by OMIM]

UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841

Function: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several

regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.

Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for

DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with

CTNNB1/beta-catenin

Gene Wiki entry for GSK3B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GSK3B gene

Entrez Gene cytogenetic band: 3q13.3 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q13.3

GSK3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M121028: (about GC identifiers)

Start:	121,028,233 bp from pter
End:	121,295,954 bp from pter
Size:	267,722 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841 (See protein sequence)

Recommended Name: Glycogen synthase kinase-3 beta

Size: 420 amino acids; 46744 Da

Subunit: Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE

PDB structures from and Proteopedia :

1GNG (3D)

1H8F (3D)

1I09 (3D)

1J1B (3D)

1J1C (3D)

1O9U (3D)

1PYX (3D)

1Q3D (3D)

1Q3W (3D)

1Q41 (3D)

1Q4L (3D)

1Q5K (3D)

1R0E (3D)

1UV5 (3D)

2JDO (3D)

2JDR (3D)

2JLD (3D)

2O5K (3D)

2OW3 (3D)

2UW9 (3D)

3CQU (3D)

3CQW (3D)

3DU8 (3D)

3E87 (3D)

3E88 (3D)

3E8D (3D)

3F7Z (3D)

3F88 (3D)

Secondary accessions: Q9BWH3 Q9UL47

Alternative splicing: 2 isoforms: P49841-1 P49841-2

Post-translational modifications:

Phosphorylated by AKT1 and ILK1¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001139628.1 NP_002084.2

ENSEMBL proteins:

ENSP00000324806 ENSP00000264235

Human Recombinant Proteins

	Invitrogen human recombinant proteins for GSK3B
	Millipore Purified and/or Recombinant GSK3B Protein
	Sigma-Aldrich Proteins for GSK3B
	R&D Systems Recombinant & Natural Proteins for GSK3B (GSK-3 beta)
	Enzo Life Sciences proteins for GSK3B
	Recombinant Proteins from Abcam (GSK3 beta, GSK3 (alpha + beta))
	Human Recombinant Proteins from Abnova (GSK3B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	14744935
GO:0005737	cytoplasm	IDA	14744935
GO:0005829	cytosol	IEA	--
GO:0030426	growth cone	IEA	--
GO:0030877	beta-catenin destruction complex	IDA	9601641 16188939

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Antibodies for GSK3B:

	Invitrogen Antibodies for GSK3B
	Millipore Mono- and Polyclonal Antibodies for the study of GSK3B
	Sigma-Aldrich Antibody Arrays and Antibodies for GSK3B
	R&D Systems Antibodies for GSK3B (GSK-3 beta, GSK-3 alpha/beta)
	Cell Signaling Technology (CST) Antibodies for GSK3B (GSK-3b)
	Antibodies from Abcam (GSK3 beta, GSK3 (alpha + beta)), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for GSK3B

Assays for GSK3B:

	Invitrogen Assays for GSK3B
	Millipore Kits and Assays for the Analysis of GSK3B
	R&D Systems ELISAs for GSK3B (GSK-3 beta, GSK-3 alpha/beta) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P49841

ProtoNet protein and cluster: P49841

UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSK3B)
		Millipore RNAi Products for the Analysis of GSK3B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (GSK3B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002093

Applied Biosystems Silencer® siRNAs for GSK3B

Sigma-Aldrich siRNA and siRNA Panels for GSK3B

Sigma-Aldrich shRNA Panels and shRNA for GSK3B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GSK3B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002093
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002093
untagged cDNA clones in CMV expression vector (see all 7): NM_002093

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002093

UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841

Function: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several

regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.

Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for

DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with

CTNNB1/beta-catenin

Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate

Enzyme regulation: Inhibited when phosphorylated by AKT1

Enzyme Number (IUBMB): EC 2.7.11.26

Genatlas biochemistry entry for GSK3B:

glycogen synthase kinase 3 beta,dual specificity protein-kinase,regulating glycogen synthesis in

skeletal muscle through Tyr activating or Ser/Thr inactivating prosphorylation,key downstream

target of PI3-kinase/AKT survival signaling pathway and involved in the regulation of

apoptosis,Drosophila Shaggy-Zeste-White 3 homolog,binding to APC-beta-catenin complex,

12 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Gsk3b):

behavior/neurological	craniofacial	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system	no phenotypic analysis
normal	skeleton

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0002039	p53 binding	IDA	14744935
GO:0004696	glycogen synthase kinase 3 activity	IDA	14744935
GO:0005524	ATP binding	IEA	--
GO:0008013	beta-catenin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/26 Sigma-Aldrich "Your Favorite Gene" Pathways for GSK3B (Your Favorite Gene powered by Ingenuity) (see all 26 )

PTEN Signaling
Reelin Signaling in Neurons
Integrin Signaling
Sonic Hedgehog Signaling
Axonal Guidance Signaling

GeneDecks GSK3B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GSK3B

5/220 Interacting proteins for GSK3B (ENSP00000324806³ P49841^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 220 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACLY	P53396¹	STRING (score=.7) EBI-373586, EBI-1042794
AKT1	P31749¹	STRING (score=.998) EBI-373586, EBI-296087
AKT2	P31751¹	STRING (score=.972) EBI-373586, EBI-296058
GYS1	P13807¹	STRING (score=.997) EBI-373586, EBI-963094
MYC	P01106²	STRING (score=.91) MINT-7025816 MINT-7025684 MINT-7025707

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000320	re-entry into mitotic cell cycle	IEA	--
GO:0005977	glycogen metabolic process	IDA	8638126
GO:0006916	anti-apoptosis	IEA	--
GO:0006950	response to stress	IEA	--
GO:0006983	ER overload response	IDA	14744935

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GSK3B

Sigma-Aldrich Small Molecules for GSK3B:

Inhibitor

Compounds for GSK3B available from Tocris Bioscience

Compound	Action	CAS number
Phospho-Glycogen Synthase Peptide-2 (substrate)	Glycogen synthase kinase-3 substrate (synthetic)
Indirubin-3'-oxime	GSK-3beta inhibitor. Also inhibits other protein kinases	[160807-49-8]
SB 415286	Potent, selective GSK-3 inhibitor	[264218-23-7]
TCS 183	Fragment 1-13 of GSK-3beta sequence
SB 216763	Potent, selective GSK-3 inhibitor	[280744-09-4]

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10/13 Novoseek chemical compound relationships for GSK3B gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	91.73	256	14985354 (6), 8809831 (4), 15661493 (3), 7911658 (2) (see all 99)
lithium	67.79	49	11579131 (6), 19442155 (4), 12787068 (3), 8710892 (3) (see all 16)
sb-216763	61.37	1	18417075 (1)
threonine	55.65	19	10076565 (2), 12787068 (1), 18547980 (1), 18851699 (1) (see all 12)
lithium chloride	54.29	5	12794074 (1), 15178691 (1), 11035789 (1)
phosphatidylinositol	41.46	15	10954722 (5), 16055672 (1), 15062551 (1), 12584189 (1) (see all 6)
acetyl-coa	9.26	2	7911658 (1)
atp	0.00	4	7911658 (2), 11343704 (1)
forskolin	0.00	2	11579131 (1), 12787068 (1)
potassium	0.00	2	18502415 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GSK3B)
		Millipore RNAi Products for the Analysis of GSK3B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (GSK3B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002093

Sigma-Aldrich siRNA and siRNA Panels for GSK3B

Sigma-Aldrich shRNA Panels and shRNA for GSK3B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002093

REFSEQ mRNAs for GSK3B gene (2 alternative transcripts):

NM_001146156.1 NM_002093.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002093

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002093
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002093
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_002093

Additional cDNA sequence:

AB451356.1 AK290897.1 AY123976.1 BC000251.1 BC012760.2 CR536510.1 CR615239.1 CR617019.1

EU302497.1 L33801.1

7 DOTS entries:

DT.75162342 DT.100814329 DT.91918846 DT.92030498 DT.95366430 DT.100682142 DT.95158463

24/218 AceView cDNA sequences (see all 218 ):

AA447980 Z43594 BI093105 F04515 BM789392 BX403207 BU155585 AA291353

N20039 BP343685 BC012760 NM_002093 AY123976 BU194539 AA351029 AI160379

BF934402 AA312353 Z39659 T17427 CA309362 AA316921 BF056411 AW198237

highest scoring ESTs for GSK3B:

L33801 AA132666 AL521665 BC000251 BC012760 BE257061 BE891089 BF085588 BF901560 BF927799

Unigene Cluster for GSK3B:

Glycogen synthase kinase 3 beta

Hs.445733 [show with all ESTs]

Unigene Representative Sequence: BC012760

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000316626 ENST00000264235

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GSK3B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GSK3B

¹ / ² / ³

9 probe-sets matching GSK3B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40645_at²^{, 3}	U95-A	1	1.00	1.00	0.34	1.27	L33801	1.00	1.00	1.00	1
52456_at²^{, 3}	U95-B	1	1.00	1.00	0.52	0.73	AA778906	0.20	1.00	0.72	1
1253_at²^{, 3}	U95-A	2	1.00	0.94	0.68	1.09	L33801	1.00	1.00	1.00	1
242336_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R51305	0.20	1.00	0.72	1
226191_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI431788	0.20	1.00	0.72	1
209945_s_at²^{, 3}	U133-A	2	1.00	0.86	--	--	BC000251	0.80	1.00	0.91	1
242336_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226191_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209945_s_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--

GeneDecks GSK3B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAGTGATCA

SOURCE GeneReport for Unigene cluster: Hs.445733
Expression variation in blood from EXPOLDB for GSK3B
UniProtKB/Swiss-Prot: GSK3B_HUMAN, P49841
Tissue specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung,
brain and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GSK3B gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GSK3B¹	--	glycogen synthase kinase 3 beta	97(n) 99.77(a)	478575 XM_535751.2 XP_535751.2
chimpanzee (Pan troglodytes)	GSK3B¹	--	glycogen synthase kinase 3 beta	98.46(n) 98.15(a)	470896 XM_001164267.1 XP_001164267.1
rat (Rattus norvegicus)	Gsk3b¹	--	glycogen synthase kinase 3 beta	92.3(n) 99.05(a)	84027 NM_032080.1 NP_114469.1
mouse (Mus musculus)	Gsk3b^{1, 5}	16⁵	glycogen synthase kinase 3 beta^{1, 5}	92.7(n)¹ 99.05(a)¹	56637¹ NM_019827.4¹ NP_062801.1¹ AB066114⁵ AF156099⁵ (see all 27)
chicken (Gallus gallus)	GSK3B¹	--	glycogen synthase kinase 3 beta	88.38(n) 96.77(a)	418335 XM_416557.2 XP_416557.2

About this table Species with no ortholog for GSK3B

ENSEMBL Gene Tree for GSK3B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GSK3B gene

RAGE² GSK3A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1005 NCBI SNPs in GSK3B are shown (see all 1005 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 244)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9846422^1,2	C,F,H	121296402(+)	`GGCTTG/CAAGAG`	1	--	ng3¹		8	EU EA WA	828
	rs3755556^1,2	C,F,H	121296174(+)	`CCGAAC/AGGAGC`	1	--	ng3¹ tfbs³		4	EU EA WA	392
	rs334558^1,2	F,H	121295972(+)	`TCAGGG/AGCTGC`	1	--	ng3¹		4	MN EA WA	450
	rs4331700^1,2	H	121027963(+)	`GTTTTC/TTTCTT`	1	--	ng5¹		4	EU EA WA	404
	rs34009575^1,2	C	121068145(+)	`GTGAAA/TTGTCC`	1	H/Q	mis¹		4	EU EA WA	420
	rs2276708^1,2	H	121295581(+)	`GGGCGG/ATGGCG`	1	--	ng3¹ ese³		5	EA EU WA	1910
	rs34002644^1,2	F	121203670(-)	`AATGGA/TTCATT`	1	G/G	syn¹		1	NA	72
	rs2199503^1,2	A,C,F,H,O	121261179(-)	`AGTTGA/GACTAA`	1	--	int¹		14	EU EA WA NA	1234
	rs1154595^1,2	A,C,F,H,O	121219284(+)	`TAATAC/TCCAAT`	1	--	int¹		12	EU EA WA NA	1052
	rs334536^1,2	A,C,F,H,O	121273402(-)	`GGTTCT/GTAATG`	1	--	int¹		11	EU EA WA NA	978

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HapMap Linkage Disequilibrium images for GSK3B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605004

10/24 Novoseek disease relationships for GSK3B gene (see all 24 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
paired helical filament	75.61	1	7686508 (1)
familial adenomatous polyposis	68.61	12	10477752 (1), 12213737 (1), 12771132 (1), 10549354 (1) (see all 11)
neurofibrillary tangles	57.67	4	10754226 (1), 18932008 (1)
alzheimers disease	56.99	24	18932008 (3), 11805297 (2), 11881998 (2), 11013232 (2) (see all 12)
late onset alzheimer disease	54.72	1	11326302 (1)
bipolar disorder	50.75	9	16289845 (4), 17628506 (1), 14729229 (1), 19442155 (1)
brain diseases	35.60	1	7758758 (1)
neurodegeneration	25.24	3	8809831 (1), 10509176 (1)
senile plaques	24.93	2	18932008 (1)
colon cancer	21.79	1	17640304 (1)

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Human Gene Mutation Database: GSK3B
Genetic Association Database: GSK3B
Human Genome Epidemiology Navigator: GSK3B (34 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/519 PubMed articles for GSK3B gene (see all 519 ):

Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter. (PubMed id 10486203)^{2, 3, 4} Lau K.F.... Shaw P.C. (1999)
No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population. (PubMed id 16289845)^{1, 3, 6} Lee K.Y....Kim Y.S. (2006)
GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. (PubMed id 16315267)^{1, 3, 6} Kwok J.B....Schofield P.R. (2005)
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. (PubMed id 11440715)^{1, 3, 4} Dajani R....Pearl L.H. (2001)
No association of GSK3beta gene (GSK3B) with Japanese schizophrenia. (PubMed id 15719395)^{1, 3, 6} Ikeda M....Ozaki N. (2005)
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation. (PubMed id 7980435)^{1, 3, 4} Stambolic V. and Woodgett J.R. (1994)
A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder. (PubMed id 14729229)^{1, 3, 6} Benedetti F....Smeraldi E. (2004)
A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. (PubMed id 15351432)^{1, 3, 6} Benedetti F....Smeraldi E. (2004)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. (PubMed id 16428445)^{3, 4} Kobayashi T....Kikuchi A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2932	HGNC: 4617	AceView: GSK3B	Ensembl:ENSG00000082701	euGenes: HUgn2932
ECgene: GSK3B	H-InvDB: GSK3B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GSK3B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for GSK3B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GSK3B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GSK3B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GSK3B		Antibodies for GSK3B
	Explore super-pooled esiRNAs		Proteins for GSK3B
	Lentivirus-delivered shRNAs for GSK3B		Small molecules for GSK3B
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GSK3B)
	Search for Antibodies
	Chimera RNAi (GSK3B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GSK3B (GSK-3b)

	Recombinant Proteins (GSK3 beta, GSK3 (alpha + beta))
	Antibodies (GSK3 beta, GSK3 (alpha + beta))

Search OriGene for GSK3B

Tocris compounds for GSK3B

	Drugs/Proteins for GSK3B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GSK3B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GSK3B Gene at Home site.
Version 2.41.1
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GSK3B Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for GSK3B

Summaries
for GSK3B

Genomic Location
for GSK3B

Proteins
for GSK3B

Protein Domains/
Families
for GSK3B

Gene Function
for GSK3B

Pathways & Interactions
for GSK3B

Drugs & Compounds
for GSK3B

Transcripts
for GSK3B

Expression
for GSK3B

Orthologs
for GSK3B

Paralogs
for GSK3B

SNPs/Variants
for GSK3B

Disorders & Mutations
for GSK3B

Medical News
for GSK3B

Publications
for GSK3B

Search for GSK3B

Genome Databases showing GSK3B

Other Databases showing GSK3B

Specialized Databases showing GSK3B

Licensable Technologies
for GSK3B

Services
for GSK3B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GSK3B Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor GSK3B

Summariesfor GSK3B

Genomic Locationfor GSK3B

Proteinsfor GSK3B

Protein Domains/Familiesfor GSK3B

Gene Functionfor GSK3B

Pathways & Interactionsfor GSK3B

Drugs & Compoundsfor GSK3B

Transcriptsfor GSK3B

Expression for GSK3B

Orthologsfor GSK3B

Paralogsfor GSK3B

SNPs/Variantsfor GSK3B

Disorders & Mutationsfor GSK3B

Medical Newsfor GSK3B

Publicationsfor GSK3B

Search for GSK3B

Genome Databases showing GSK3B

Other Databases showing GSK3B

Specialized Databases showing GSK3B

Licensable Technologiesfor GSK3B

Servicesfor GSK3B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GSK3B

Summaries
for GSK3B

Genomic Location
for GSK3B

Proteins
for GSK3B

Protein Domains/
Families
for GSK3B

Gene Function
for GSK3B

Pathways & Interactions
for GSK3B

Drugs & Compounds
for GSK3B

Transcripts
for GSK3B

Expression
for GSK3B

Orthologs
for GSK3B

Paralogs
for GSK3B

SNPs/Variants
for GSK3B

Disorders & Mutations
for GSK3B

Medical News
for GSK3B

Publications
for GSK3B

Licensable Technologies
for GSK3B

Services
for GSK3B