GSK3A Gene
protein-coding GIFtS : 69 GCID: GC19 M042734
glycogen synthase kinase 3 alpha
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Aliasesfor GSK3A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Glycogen Synthase Kinase 3 Alpha 1 2 Glycogen Synthase Kinase-3 Alpha2 Serine/Threonine-Protein Kinase GSK3A2 3 EC 2.7.11.13 GSK-3 Alpha2 3 EC 2.7.118 EC 2.7.11.263 8
Export aliases for GSK3A gene to outside databases Previous GC identifers: GC19M043380 GC19M043126 GC19M047410 GC19M047426 GC19M039164
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Summariesfor GSK3A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for GSK3A : This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. (provided by RefSeq, Oct 2011) UniProtKB/Swiss-Prot: GSK3A_HUMAN, P49840 Function : Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucosehomeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth summary
for GSK3A : Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), wasoriginally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function incell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathologicalconditions including cancer and diabetes and is increasingly seen as an important component of neurologicaldiseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer'sdisease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3betaare found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptortrafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcriptionfactors and structural proteins, and is part of the signal transduction cascade of a large number of growthfactors and cytokines. The activity of GSK is regulated by phosphorylation (Akt, S6K, RSK, PKA and PKC),dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta-catenin, axin, CK1 and theAPC complex). Gene Wiki entry for GSK3A
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Genomic Viewsfor GSK3A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the GSK3A gene promoter:CREB p53 AP-1 deltaCREB ATF-2 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for GSK3A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13 GSK3A Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M042734: view genomic region
(about GC identifiers )
Start: 42,734,338 bp from pter End:
42,746,777 bp from pter
Size: 12,440 bases Orientation:
minus strand
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Proteinsfor GSK3A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: GSK3A_HUMAN, P49840 See
protein sequence )Recommended Name: Size : 483 amino acids; 50981 DaSubunit : Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-cateninMiscellaneous : Higher expression and activity of GSK3A are found in the skeletal muscle (vastus lateralis) of patientswith type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350)
1 PDB 3D structure from :2DFM (3D) Secondary accessions : O14959Explore the universe of human proteins at neXtProt for GSK3A: NX_P49840 Post-translational modifications:
Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-2791
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P49840 4/19 DME Specific Peptides for GSK3A (P49840 ) (see all 19 )GSK3A Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_063937.2 ENSEMBL proteins: ENSP00000222330 ENSP00000381301 ENSP00000412663 Reactome Protein details: P49840 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing GSK3A Antibody Products: Assay Products for GSK3A:
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Protein
Domains /for GSK3A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P49840 ProtoNet protein and cluster: P49840
UniProtKB/Swiss-Prot: GSK3A_HUMAN, P49840 Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamilySimilarity : Contains 1 protein kinase domain
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Functionfor GSK3A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: GSK3A_HUMAN, P49840 Function : Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucosehomeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth Catalytic activity : ATP + [tau protein] = ADP + [tau protein] phosphateCatalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation atSer-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium
Genatlas biochemistry entry for GSK3A glycogen synthase kinase 3 alpha,regulator of glycogen synthesis in skeletal muscle,unstabilized in response to insulin with both protein level and activity increased by heat stress Enzyme Numbers (IUBMB): EC 2.7.11.26 1 2 EC 2.7.11 2 EC 2.7.11.1 1 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GSK3A (NM_019884 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSK3A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GSK3A
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3A
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing 4 GenomeRNAi human phenotypes for GSK3A :Animal Models: Gsk3a tm1.1Jrw for GSK3A12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Gsk3a) :About GeneDecksing
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Pathways & Interactionsfor GSK3A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/46 super-pathways (see all 46 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Signaling by FGFR 2 IL-9 Signaling Pathways 3 PIP3 activates AKT signaling 4 Development IGF-RI signaling 5 Activation of cAMP-Dependent PKA
Pathway sources See GeneCards unified pathways Show all pathways 5/9 (see all 9 )5/9 (see all 9 )5/16 (see all 16 )4 4 5/9 (see all 9 )5/11 (see all 11 ) 5/35 (see all 35 )1 (Kegg details for GSK3A) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GSK3A STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/59 Interacting proteins for GSK3A (P49840 1 , 2 , 3 ENSP00000222330 4 via UniProtKB, MINT, STRING , and/or I2D (see all 59 )Interactant Interaction Details GeneCard External ID(s) AXIN1 O15169 2 , 3 ENSP00000262320 4 MINT-4544606 I2D:
score=3 STRING: ENSP00000262320 BICD1 Q96G01 2 , 3 ENSP00000281474 4 MINT-4051287 I2D:
score=1 STRING: ENSP00000281474 DEAF1 O75398 1 , 3 ENSP00000371846 4 EBI-1044067,EBI-718185 I2D:
score=1 STRING: ENSP00000371846 YWHAG P61981 2 , 3 ENSP00000306330 4 MINT-50786 I2D:
score=4 STRING: ENSP00000306330 CREM Q03060 3 ENSP00000265372 4 I2D:
score=2 STRING: ENSP00000265372
About this table Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003073 regulation of systemic arterial blood pressure
ISS -- GO:0003214 cardiac left ventricle morphogenesis
ISS -- GO:0005977 glycogen metabolic process
IEA -- GO:0006349 regulation of gene expression by genetic imprinting
-- -- GO:0006468 protein phosphorylation
IDA 11035810
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Drugs & Compoundsfor GSK3A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for GSK3A
Compounds for GSK3A available from Tocris Bioscience About this table Compound Action
CAS
# L803-mts Selective inhibitor of GSK-3 -- FRATide GSK-3 inhibitor [251087-38-4] BIO-acetoxime Selective GSK-3alpha/beta inhibitor [667463-85-6] SB 415286 Potent, selective GSK-3 inhibitor [264218-23-7] SB 216763 Potent, selective GSK-3 inhibitor [280744-09-4]
2 HMDB Compounds for GSK3A About this table 7 Novoseek chemical compound relationships for GSK3A gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen
83.2
42
7931292 (2), 7891113 (2), 11113543 (2), 7787767 (1) (see all 24 )
lithium
54.2
2
18322101 (1), 17456772 (1)
serine
52.7
9
7514166 (2), 18322101 (1), 7891113 (1), 11113543 (1)
threonine
47.2
8
7514166 (2), 7695638 (1), 11113543 (1)
okadaic acid
32.2
7
8655632 (3), 7514166 (2)
tyrosine
28.2
51
7890813 (5), 8825421 (5), 9215524 (4), 7514166 (4) (see all 5 )
genistein
23.1
6
9215524 (2), 7806586 (2)
GSK3A
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Transcriptsfor GSK3A gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for GSK3A gene: NM_019884.2 Unigene Cluster for GSK3A:
Glycogen synthase kinase 3 alpha Hs.466828 [show with all ESTs ] Unigene Representative Sequence: CR749620 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000222330 (uc002otb.1 ) ENST00000398249 (uc002ota.1 ) ENST00000453535 ENST00000493059 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: GSK3A (NM_019884 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GSK3A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GSK3A
Additional cDNA sequence: BC027984.1 BC051865.2 CR749620.1 D63424.1 L40027.1
16 DOTS entries : DT.449417 DT.91656740
DT.92456675 DT.100821603 DT.40123674 DT.100821602 DT.95210349 DT.100821609 DT.121444278 DT.40123671 DT.95210342 DT.97799184 DT.97810039 DT.91645606 DT.95354451 DT.97766011 24/530 AceView cDNA sequences (see all 530 ):
BX420137 BM975480 AI760234 AI336462 BQ646002 BU617983 AA341368 CD365605 AA749280 AI682929 AI347109 BM770231 BQ671377 BF927805 AI005372 BM770276 BM771463 AI920971 AI635545 AI393051 CA415843 BG152775 BQ574526 AW470070 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for GSK3A About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 SP1 : - SP2 : SP3 :
ECgene alternative splicing isoforms for GSK3A
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Expression for GSK3A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GSK3A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAACCTGAA
About this image GSK3A expression in embryonic tissues and stem cells About this table See GSK3A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for GSK3A SOURCE GeneReport for Unigene cluster: Hs.466828 SABiosciences Expression via Pathway-Focused PCR Arrays including GSK3A (see all 7 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3A
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Orthologsfor GSK3A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for GSK3A gene from 7/33 species (see all 33 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia GSK3A6
--
87(a)
1 → many
GL343909.1(9018-13403)
zebrafish Actinopterygii gsk3a2
glycogen synthase kinase 3 alpha
78.29(n)
30664 AJ223501.1
fruit fly Insecta sgg3
circadian rhythm protein serine/threonine
78(a)
--
worm Secernentea Y18D10A.53
Eukaryotic protein kinase domain
76(a)
I(12827414-12832717) --
baker's yeast Saccharomycetes MCK1(YNL307C)4 1
Protein serine/threonine/tyrosine (dual-specificity) more 4 1
58.76(n) 1 59.32(a) 1
14(57573-56446) 4 855170 1 NP_013859.1 1 855409 4 NP_014092.1 4
thale cress eudicotyledons BIN26 6 see all 10 )
Shaggy-related protein kinase zeta(see all 10 )
60(a) 58(a) (see all 10 )
many ↔ manymany ↔ many(see all 10 )
4(10296273-10301228) 2(13182069-13185949)
rice Liliopsida AK070062.12
--
75.93(n)
AK070062.1
ENSEMBL Gene Tree for GSK3A (if available)TreeFam Gene Tree for GSK3A (if available)
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Paralogsfor GSK3A gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for GSK3A gene GSK3B 2 18/34 SIMAP similar genes for GSK3A using alignment to 2 protein entries: GSK3A_HUMAN (see all proteins )
(see all similar genes ):DKFZp686D0638 GSK3B MAK CDKL2 CDC2 CDK3 PCTK3 CCRK CDK1 CDK15 CDK17 CDK5 CDK7 DKFZp686O0215 MAPK3 MOK DKFZp686L20222 CDK2 About GeneDecksing
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Genomic Variantsfor GSK3A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for GSK3A (42734338 - 42746777 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for GSK3A 1 CNV 5445
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor GSK3A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 606784
OMIM disorders : --20/23 (see all 23 ): About MalaCards alzheimer's disease amyotrophic lateral sclerosis neurologic diseases lateral sclerosis coronary heart disease insulin resistance brain disease multiple myeloma parkinson's disease myeloma leiomyoma colon cancer schizophrenia pancreatic cancer prostate cancer pancreatitis hypoxia prostatitis thyroiditis melanoma 8 Novoseek disease relationships for GSK3A gene About this table
Human Genome Epidemiology (HuGE) Navigator: GSK3A (5 documents) Export disorders for GSK3A gene to outside databases
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Publicationsfor GSK3A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for GSK3A gene, integrated from 9 sources (see all 156 ):(articles sorted by number of sources associating them with GSK3A) Utopia : connect your pdf to the dynamic
Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes. (PubMed id 9809441) 1 , 3, 9(1998) Glycogen synthase kinase 3: more than a namesake. (PubMed id 19366350) 1 , 2 (2009) The DNA sequence and biology of human chromosome 19. (PubMed id 15057824) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. (PubMed id 12761548) 1 , 2 (2003) Glycogen synthase kinase-3: properties, functions, and regulation. (PubMed id 11749387) 1 , 2 (2001) Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain. (PubMed id 7931292) 1 , 9(1994) Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells. (PubMed id 17569761) 1 , 9(2007) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. (PubMed id 11035810) 1 , 9(2000) Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. (PubMed id 8725894) 1 , 9(1996)
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External Searches for GSK3A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing GSK3A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing GSK3A gene
(According to HUGE )
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Specialized Databases showing GSK3A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for GSK3A gene: GSK3A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor GSK3A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for GSK3A OriGene shRNA RFP for GSK3A OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for GSK3A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for GSK3A OriGene 3'-UTR Clone for GSK3A OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for GSK3A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for GSK3A OriGene Custom Protein Services for GSK3A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSK3A QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for GSK3A
Tocris compounds for GSK3A
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3A
ThermoFisher Antibody for GSK3A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat GSK3A
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summary
for 
and Proteopedia 
for GSK3A:
BioSystems Pathways for GSK3A (
Kegg Pathway 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Selective marker
In-situ hybridization
