Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GSK3A Gene

protein-coding   GIFtS: 72
GCID: GC19M042734

Glycogen Synthase Kinase 3 Alpha

  See GSK3A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glycogen Synthase Kinase 3 Alpha1 2     Glycogen Synthase Kinase-3 Alpha2
Serine/Threonine-Protein Kinase GSK3A2 3     EC 2.7.11.13
GSK-3 Alpha2 3     EC 2.7.118
EC 2.7.11.263 8     

External Ids:    HGNC: 46161   Entrez Gene: 29312   Ensembl: ENSG000001057237   OMIM: 6067845   UniProtKB: P498403   

Export aliases for GSK3A gene to outside databases

Previous GC identifers: GC19M043380 GC19M043126 GC19M047410 GC19M047426 GC19M039164


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GSK3A Gene:
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory
proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and
PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's
disease. (provided by RefSeq, Oct 2011)

GeneCards Summary for GSK3A Gene:
GSK3A (glycogen synthase kinase 3 alpha) is a protein-coding gene. Diseases associated with GSK3A include schizophrenia. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase A catalytic subunit binding. An important paralog of this gene is ENSG00000268643.

UniProtKB/Swiss-Prot: GSK3A_HUMAN, P49840
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of
glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating
and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed
phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by
phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in
liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of
transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear
CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived
amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic
beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation
of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation

summary for GSK3A Gene:
Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was
originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in
cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological
conditions including cancer and diabetes and is increasingly seen as an important component of neurological
diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's
disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta
are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor
trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription
factors and structural proteins, and is part of the signal transduction cascade of a large number of growth
factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt, S6K, RSK, PKA and PKC),
dephosphorylation (PP1 and PP2A), and by binding to protein complexes (with beta-catenin, axin, CK1 and the
APC complex).

Gene Wiki entry for GSK3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GSK3A gene promoter:
         CREB   p53   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GSK3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSK3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13

GSK3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSK3A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042734:  view genomic region     (about GC identifiers)

Start:
42,734,338 bp from pter      End:
42,746,777 bp from pter
Size:
12,440 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GSK3A_HUMAN, P49840 (See protein sequence)
Recommended Name: Glycogen synthase kinase-3 alpha  
Size: 483 amino acids; 50981 Da
Subunit: Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-catenin
Miscellaneous: Higher expression and activity of GSK3A are found in the skeletal muscle (vastus lateralis) of
patients with type 2 diabetes (PubMed:10868943). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been
identified and characterized in preclinical models for treatments of type 2 diabetes (PubMed:19366350)
1 PDB 3D structure from and Proteopedia for GSK3A:
2DFM (3D)    
Secondary accessions: O14959

Explore the universe of human proteins at neXtProt for GSK3A: NX_P49840

Explore proteomics data for GSK3A at MOPED

Post-translational modifications: 

  • Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase
    phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by
    phosphorylation at Tyr-2791
  • Ubiquitination2 at Lys268, Lys355, Lys360
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GSK3A (P49840) (see all 19)
     CDFGSAK  YFFYSSG  LPPLFNF  VPETVYR 


    See GSK3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_063937.2  
    ENSEMBL proteins: 
     ENSP00000222330   ENSP00000381301   ENSP00000412663  
    Reactome Protein details: P49840

    GSK3A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant GSK3A Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for GSK3A
    OriGene Protein Over-expression Lysate for GSK3A
    OriGene MassSpec for GSK3A
    OriGene Custom Protein Services for GSK3A
    GenScript Custom Purified and Recombinant Proteins Services for GSK3A
    Novus Biologicals GSK3A Proteins
    Novus Biologicals GSK3A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for GSK3A 

     
    antibodies-online proteins for GSK3A (8 products) 

     
    antibodies-online peptides for GSK3A

    GSK3A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GSK3A
    R&D Systems Antibodies for GSK3A (GSK-3 alpha)
    Cell Signaling Technology (CST) Antibodies for GSK3A 
    OriGene Antibodies for GSK3A
    OriGene Custom Antibody Services for GSK3A
    Novus Biologicals GSK3A Antibodies
    Abcam antibodies for GSK3A (P49840, P49841)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for GSK3A
    antibodies-online antibodies for GSK3A (235 products) 

    GSK3A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GSK3A
    R&D Systems ELISAs for GSK3A (GSK-3 alpha)
    GenScript GSK3A-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for GSK3A 
    antibodies-online kits for GSK3A (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: glycogen synthase kinase 3 alpha
    GSK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49840

    ProtoNet protein and cluster: P49840

    UniProtKB/Swiss-Prot: GSK3A_HUMAN, P49840
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with GSK3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GSK3A_HUMAN, P49840
    Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of
    glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating
    and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed
    phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by
    phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in
    liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of
    transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear
    CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived
    amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic
    beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation
    of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation
    at Ser-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of
    substrates to the active site. Inhibited by lithium

         Genatlas biochemistry entry for GSK3A:
    glycogen synthase kinase 3 alpha,regulator of glycogen synthesis in skeletal muscle,unstabilized in response to
    insulin with both protein level and activity increased by heat stress

         Enzyme Numbers (IUBMB): EC 2.7.11.261 2 EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11035810
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16365045
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with GSK3A           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for GSK3A:
     Decreased influenza A virus in  Decreased substrate adherent c  Increased viability with TRAIL  PARP inhibitor sensitization 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Gsk3a) (see all 16):
     adipose tissue  behavior/neurological  craniofacial  digestive/alimentary  growth/size/body 
     homeostasis/metabolism  immune system  liver/biliary system  nervous system  no phenotypic analysis 
     normal  other  pigmentation  renal/urinary system  skeleton 

    Find genes that share phenotypes with GSK3A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Gsk3atm1.1Jrw for GSK3A

       genOway: Develop your customized and physiologically relevant rodent model for GSK3A

    miRNA
    Products:
        
    miRTarBase miRNAs that target GSK3A:
    hsa-let-7c-5p (MIRT051796), hsa-let-7b-5p (MIRT052236), hsa-mir-744-5p (MIRT037683), hsa-mir-149-5p (MIRT045619)

    Block miRNA regulation of human, mouse, rat GSK3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GSK3A (see all 13):
    hsa-miR-485-5p hsa-miR-4318 hsa-miR-324-3p hsa-miR-887 hsa-miR-3617 hsa-miR-3653 hsa-miR-138-2* hsa-miR-182*
    SwitchGear 3'UTR luciferase reporter plasmidGSK3A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GSK3A
    Predesigned siRNA for gene silencing in human, mouse, rat GSK3A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSK3A

    Clone
    Products:
         
    OriGene clones in human, mouse for GSK3A (see all 6)
    OriGene ORF clones in mouse, rat for GSK3A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSK3A (NM_019884)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSK3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSK3A
    Addgene plasmids for GSK3A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GSK3A
    Browse ESI BIO Cell Lines and PureStem Progenitors for GSK3A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS11035810
    GO:0030877beta-catenin destruction complex TAS19366350

    Find genes that share ontologies with GSK3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GSK3A About   (see all 48)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Adipocytokines and Insulin Signaling0.34
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    PIP3 activates AKT signaling0.88
    Signaling by ERBB40.66
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56


    Find genes that share SuperPaths with GSK3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for GSK3A (see all 10)
        Wnt Signaling Pathways
    IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GSK3A (see all 16)
        DHA Signaling
    PKA Signaling
    Sertoli-Sertoli Cell Junction Dynamics
    IL-4 Pathway
    Molecular Mechanisms of Cancer

    4 Cell Signaling Technology (CST) Pathways for GSK3A
        Wnt / Hedgehog / Notch
    Neuroscience
    PI3K / Akt Signaling
    Glucose / Energy Metabolism

    4 Tocris Bioscience Pathways for GSK3A
        Akt Pathway
    NF-kappaB Pathway
    MAPK Pathway
    mTOR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for GSK3A (see all 9)
        G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Signal transduction AKT signaling
    Development Thrombopoietin-regulated cell processes

    Selected BioSystems Pathways for GSK3A (see all 10)
        Insulin Signaling
    Glycogen Metabolism
    Integrated Breast Cancer Pathway
    SREBP signalling
    IL-5 Signaling Pathway

    3 Reactome Pathways for GSK3A
        AKT phosphorylates targets in the cytosol
    XBP1(S) activates chaperone genes
    Constitutive PI3K/AKT Signaling in Cancer


    3 Kegg Pathways  (Kegg details for GSK3A):
        Chemokine signaling pathway
    Dopaminergic synapse
    Non-alcoholic fatty liver disease (NAFLD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSK3A (see all 7): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              WNT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GSK3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GSK3A (P498401, 2, 3 ENSP000002223304) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151691, 2, 3, ENSP000002623204EBI-1044067,EBI-710484 MINT-4544606 I2D: score=3 STRING: ENSP00000262320
    BICD1Q96G012, 3, ENSP000002814744MINT-4051287 I2D: score=1 STRING: ENSP00000281474
    DEAF1O753981, 3, ENSP000003718464EBI-1044067,EBI-718185 I2D: score=1 STRING: ENSP00000371846
    YWHAGP619812, 3, ENSP000003063304MINT-50786 I2D: score=4 STRING: ENSP00000306330
    CREMQ030603, ENSP000002653724I2D: score=2 STRING: ENSP00000265372
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003073regulation of systemic arterial blood pressure ISS--
    GO:0003214cardiac left ventricle morphogenesis ISS--
    GO:0005977glycogen metabolic process IEA--
    GO:0006468protein phosphorylation IDA11035810
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    Find genes that share ontologies with GSK3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GSK3A
    6 ApexBio Compounds for GSK3A     About this table
    CompoundAction CAS #
    AR-A014418Cell-permeable GSK-3beta inhibitor[487021-52-3]
    CHIR-98014selective and ATP-competitive inhibitor of GSK-3beta[252935-94-7]
    CHIR-99021 (CT99021)Cell-permeable, ATP-competitive GSK-3 inhibitor[252917-06-9]
    LY2090314potent inhibitor of glycogen synthase kinase-3[603288-22-8]
    SB 216763Potent and selective, ATP-competitive GSK-3 inhibitor[280744-09-4]
    SB 415286Potent and selective GSK-3 inhibitor[264218-23-7]

    Compounds for GSK3A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BIO Potent, selective GSK-3 inhibitor [667463-62-9]
    BIO-acetoximeSelective GSK-3alpha/beta inhibitor[667463-85-6]
    MeBIOInactive analog of BIO (Cat. No. 3194)[667463-95-8]
    TWS 119GSK-3beta inhibitor; induces neuronal differentiation in ESCs[601514-19-6]
    SB 216763 Potent, selective GSK-3 inhibitor [280744-09-4]

    2 HMDB Compounds for GSK3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    7 Novoseek inferred chemical compound relationships for GSK3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 83.2 42 7931292 (2), 7891113 (2), 11113543 (2), 7787767 (1) (see all 24)
    lithium 54.2 2 18322101 (1), 17456772 (1)
    serine 52.7 9 7514166 (2), 18322101 (1), 7891113 (1), 11113543 (1)
    threonine 47.2 8 7514166 (2), 7695638 (1), 11113543 (1)
    okadaic acid 32.2 7 8655632 (3), 7514166 (2)
    tyrosine 28.2 51 7890813 (5), 8825421 (5), 9215524 (4), 7514166 (4) (see all 5)
    genistein 23.1 6 9215524 (2), 7806586 (2)



    Find genes that share compounds with GSK3A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GSK3A gene: 
    NM_019884.2  

    Unigene Cluster for GSK3A:

    Glycogen synthase kinase 3 alpha
    Hs.466828  [show with all ESTs]
    Unigene Representative Sequence: CR749620
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222330(uc002otb.1) ENST00000398249(uc002ota.1) ENST00000453535
    ENST00000493059
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GSK3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GSK3A (see all 13):
    hsa-miR-485-5p hsa-miR-4318 hsa-miR-324-3p hsa-miR-887 hsa-miR-3617 hsa-miR-3653 hsa-miR-138-2* hsa-miR-182*
    SwitchGear 3'UTR luciferase reporter plasmidGSK3A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GSK3A
    Predesigned siRNA for gene silencing in human, mouse, rat GSK3A
    Clone
    Products:
         
    OriGene clones in human, mouse for GSK3A (see all 6)
    OriGene ORF clones in mouse, rat for GSK3A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSK3A (NM_019884)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSK3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSK3A
    Addgene plasmids for GSK3A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GSK3A
    OriGene qSTAR qPCR primer pairs in human, mouse for GSK3A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSK3A
      QuantiTect SYBR Green Assays in human, mouse, rat GSK3A
      QuantiFast Probe-based Assays in human, mouse, rat GSK3A

    Additional mRNA sequence: 

    BC027984.1 BC051865.2 CR749620.1 D63424.1 L40027.1 

    16 DOTS entries:

    DT.449417  DT.91656740  DT.92456675  DT.100821603  DT.40123674  DT.100821602  DT.95210349  DT.100821609 
    DT.121444278  DT.40123671  DT.95210342  DT.97799184  DT.97810039  DT.91645606  DT.95354451  DT.97766011 

    Selected AceView cDNA sequences (see all 530):

    AI825095 BX282169 BM707789 BQ026791 AI270547 BC051865 BQ639323 AI632196 
    CR593340 AA295634 BM677955 F05075 AI873860 BU625841 BM905776 BQ774755 
    BU156430 BQ185653 BM478839 BQ653062 BQ651422 CB852788 BU849941 BQ647694 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GSK3A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                                              -                     
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for GSK3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GSK3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACCTGAA
    GSK3A Expression
    About this image


    GSK3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Epiblast (Early Embryonic Tissues)
             Early Epiblast Cells Epiblast
    GSK3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GSK3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466828
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GSK3A (see all 7): 
              Insulin Signaling Pathway in human mouse rat
              Tight Junctions in human mouse rat
              WNT Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GSK3A
    OriGene qSTAR qPCR primer pairs in human, mouse for GSK3A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSK3A
    QuantiTect SYBR Green Assays in human, mouse, rat GSK3A
    QuantiFast Probe-based Assays in human, mouse, rat GSK3A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GSK3A gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsk3a1 , 5 glycogen synthase kinase 3 alpha1, 5 89.53(n)1
    95.09(a)1
      7 (13.73 cM)5
    6064961  NM_001031667.11  NP_001026837.11 
     252282585 
    lizard
    (Anolis carolinensis)
    Reptilia --
    glycogen synthase kinase 3 beta-like
    83(a)
    1 → many
    GL343909.1(7757-13765)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gsk3a1 glycogen synthase kinase 3 alpha 75.37(n)
    86.26(a)
      100144645  XM_002936404.2  XP_002936450.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gsk3a2 glycogen synthase kinase 3 alpha 78.29(n)   30664  AJ223501.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sgg3 circadian rhythm protein
    serine/threonine kinase
    78(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y18D10A.53 Eukaryotic protein kinase domain 76(a)
    (best of 6)
      I(12827414-12832717)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MCK1(YNL307C)4
    RIM111
    Protein serine/threonine/tyrosine (dual-specificity) more4
    RIM111
    58.76(n)1
    59.32(a)1
      14(57573-56446)4
    8551701  NP_013859.11  8554094 
     NP_014092.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATSK121 ATSK12 62.75(n)
    67.05(a)
      819753  NM_111458.4  NP_187235.1 
    rice
    (Oryza sativa)
    Liliopsida AK070062.12   -- 75.93(n)    AK070062.1 


    ENSEMBL Gene Tree for GSK3A (if available)
    TreeFam Gene Tree for GSK3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GSK3A gene
    ENSG000002686432  GSK3B2  
    Selected SIMAP similar genes for GSK3A using alignment to 2 protein entries:     GSK3A_HUMAN (see all proteins) (see all similar genes):
    DKFZp686D0638    GSK3B    MAK    CDKL2    CDC2    CDK3
    PCTK3    CCRK    CDK1    CDK17    CDK5    CDK7
    DKFZp686O0215    MOK    MAPK3    DKFZp686L20222    CDK2    MAPK1

    Find genes that share paralogs with GSK3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GSK3A (see all 246)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841386561,2
    --42733838(+) GAAATG/TAAGGC 1 -- int10--------
    rs37452331,2
    C,F,H--42733865(+) TTCCAT/CCTCCA 1 -- int119Minor allele frequency- C:0.11EA NS NA CSA WA 3827
    rs1470019651,2
    C--42734027(+) AAGCTC/TCATGG 1 -- int10--------
    rs1897914441,2
    --42734034(+) ATGGCC/TTTCCC 1 -- int10--------
    rs1460284531,2
    C--42734328(+) CAGCCA/GGACAG 1 -- int10--------
    rs1809933841,2
    --42734536(+) GAATCA/GACGTT 1 -- ut310--------
    rs10543111,2
    C,F,H--42734682(-) GCCCCT/CTCCCC 1 -- ut315Minor allele frequency- C:0.21MN NS 928
    rs1997081151,2
    --42734940(+) TGGTGA/GGGCCC 1 -- ut310--------
    rs2013109071,2
    --42735007(+) TCGGAA/GTCTCA 2 T I mis10--------
    rs354545021,2,,4
    C--42735015(+) TCAGTT/AAAAGC 2 /L /F mis12Minor allele frequency- A:0.00NA 4

    HapMap Linkage Disequilibrium report for GSK3A (42734338 - 42746777 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GSK3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv520239CNV Loss19592680
    nsv833834CNV Loss17160897
    dgv3884n71CNV Loss21882294
    nsv833833CNV Loss17160897
    nsv911782CNV Loss21882294
    nsv911785CNV Loss21882294
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GSK3A
    DNA2.0 Custom Variant and Variant Library Synthesis for GSK3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606784    OMIM disorders: --

    1 disease for GSK3A:    
    About MalaCards
    schizophrenia


    Find genes that share disorders with GSK3A           About GenesLikeMe

    8 Novoseek inferred disease relationships for GSK3A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurofibrillary tangles 51.3 1 8725894 (1)
    brain diseases 42.4 4 7931292 (3)
    alzheimers disease 41 6 7931292 (3), 1336152 (1), 7704571 (1)
    neoplastic transformation 34.8 1 7593269 (1)
    shock 12.2 1 8655632 (1)
    schizophrenia 6.99 6 8530529 (3), 14518171 (1)
    tumors 0 11 7593269 (3), 8825421 (3), 7890813 (2), 8655632 (1)
    carcinoma 0 6 9215524 (2), 8825421 (1)

    Genetic Association Database (GAD): GSK3A
    Human Genome Epidemiology (HuGE) Navigator: GSK3A (5 documents)

    Export disorders for GSK3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GSK3A gene, integrated from 10 sources (see all 170):
    (articles sorted by number of sources associating them with GSK3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes. (PubMed id 9809441)1, 3, 9 Shaw P.C....Anderton B.H. (Genome 1998)
    2. Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-I^ activity. (PubMed id 20113358)1, 4 Benedetti F....Smeraldi E. (Genes Brain Behav. 2010)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. Glycogen synthase kinase 3: more than a namesake. (PubMed id 19366350)1, 2 Rayasam G.V.... Ray A. (Br. J. Pharmacol. 2009)
    5. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (Hum. Mol. Genet. 2009)
    6. Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. (PubMed id 18500637)1, 4 Souza R.P....Kennedy J.L. (Psychopharmacology (Berl.) 2008)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. (PubMed id 12761548)1, 2 Phiel C.J.... Klein P.S. (Nature 2003)
    10. Glycogen synthase kinase-3: properties, functions, and regulation. (PubMed id 11749387)1, 2 Ali A.... Woodgett J.R. (Chem. Rev. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2931 HGNC: 4616 AceView: ERFandGSK3A Ensembl:ENSG00000105723 euGenes: HUgn2931
    ECgene: GSK3A Kegg: 2931 H-InvDB: GSK3A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GSK3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GSK3A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GSK3A gene:
    Search GeneIP for patents involving GSK3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Purified and/or Recombinant GSK3A Protein
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GSK3A
     
     EMD Millipore genomic analysis products

      
     Antibodies for GSK3A (GSK-3 alpha)   Browse Cell Culture Products  
     ELISAs for GSK3A (GSK-3 alpha)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GSK3A   OriGene RNAi products in human, mouse, rat for GSK3A  
     OriGene qPCR primer pairs and template standards for GSK3A   OriGene Protein Over-expression Lysate for GSK3A  
     OriGene MassSpec for GSK3A   OriGene clones in human, mouse for GSK3A  
     OriGene qSTAR qPCR primer pairs in human, mouse for GSK3A   OriGene Purified Protein for GSK3A  
     OriGene ORF clones in mouse, rat for GSK3A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GSK3A   OriGene Custom Protein Services for GSK3A  

     
     
     Block miRNA regulation of human, mouse, rat GSK3A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GSK3A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GSK3A Predesigned siRNA for gene silencing in human, mouse, rat GSK3A
     QuantiFast Probe-based Assays in human, mouse, rat GSK3A QuantiTect SYBR Green Assays in human, mouse, rat GSK3A
     PCR Arrays including human, mouse, rat GSK3A Search Chromatin IP Primers for GSK3A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GSK3A  GeneGlobe Interaction Network for GSK3A
     Regulatory tfbs in GSK3A promoter
     GenScript Custom Purified and Recombinant Proteins Services for GSK3A GenScript cDNA clones with any tag delivered in your preferred vector for GSK3A
     GenScript GSK3A-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for GSK3A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for GSK3A 

     Tocris compounds for GSK3A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for GSK3A
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GSK3A antibodies
     GSK3A proteins
     GSK3A lysates
     Antibodies for GSK3A
     See all of Abcam's Antibodies, Kits and Proteins for GSK3A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for GSK3A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSK3A
     SwitchGear 3'UTR luciferase reporter plasmids for GSK3A
     Browse SwitchGear Promoter luciferase reporter plasmids for GSK3A
     ThermoFisher Antibody for GSK3A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSK3A
     ApexBio compounds for GSK3A
     Addgene plasmids for GSK3A
      Search eBioscience for proteins for GSK3A
      Search eBioscience for elisas for GSK3A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for GSK3A
     antibodies-online antibodies for GSK3A (235 products)
     antibodies-online kits for GSK3A (29 products)
     antibodies-online peptides for GSK3A
     antibodies-online proteins for GSK3A (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GSK3A gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4