Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GSG2 Gene

Aliases for GSG2 Gene

  • Germ Cell Associated 2, Haspin 2 3 5
  • Haploid Germ Cell-Specific Nuclear Protein Kinase 3 4
  • Germ Cell-Specific Gene 2 Protein 3 4
  • H-Haspin 3 4
  • Serine/Threonine-Protein Kinase Haspin 3
  • Germ Cell Associated 2 (Haspin) 2
  • EC 2.7.11.1 4
  • HASPIN 3

External Ids for GSG2 Gene

Previous GeneCards Identifiers for GSG2 Gene

  • GC17P003939
  • GC17P003578
  • GC17P003833
  • GC17P003573
  • GC17P003517
  • GC17P003627

Summaries for GSG2 Gene

GeneCards Summary for GSG2 Gene

GSG2 (Germ Cell Associated 2, Haspin) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for GSG2 Gene

  • Serine/threonine-protein kinase that phosphorylates histone H3 at Thr-3 (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Tocris Summary for GSG2 Gene

  • Haspin (germ cell associated 2), EC 2.7.11.1, is a serine/threonine kinase that has a critical function in mitosis. The enzyme phosphorylates threonine-3 on histone H3 during mitosis.

Gene Wiki entry for GSG2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSG2 Gene

Genomics for GSG2 Gene

Regulatory Elements for GSG2 Gene

Enhancers for GSG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F003710 1.1 Ensembl ENCODE 17.8 -12.1 -12119 3.6 HDGF HDAC1 TBL1XR1 BMI1 ZBTB40 ZNF121 ETV6 CREM JUNB TBX21 GSG2 ENSG00000262692 P2RX5 P2RX5-TAX1BP3
GH17F003797 1.6 FANTOM5 Ensembl ENCODE 11.9 +78.0 78034 8.3 PKNOX1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS PAF1 SP5 GSG2 P2RX5 NCBP3 ZZEF1 CTNS P2RX1 ITGAE GC17M003807
GH17F003790 1.5 FANTOM5 Ensembl ENCODE 12 +67.4 67398 2.2 PKNOX1 SIN3A FEZF1 ZBTB40 ZNF335 GLIS2 ZNF207 ETV6 FOS CREM GSG2 NCBP3 EMC6 TAX1BP3 CTNS ZZEF1 P2RX1 ITGAE ENSG00000262358
GH17F003762 1.4 Ensembl ENCODE 12.5 +41.2 41179 4.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS GSG2 ENSG00000262358 ITGAE
GH17F003749 1.3 FANTOM5 Ensembl ENCODE 12.8 +26.8 26788 2.2 HDGF PKNOX1 MAZ BHLHE40 EBF1 TBX21 EP300 ZFHX2 POLR2A IKZF1 GSG2 P2RX5 NCBP3 OR1E2 OR3A2 ATP2A3 ENSG00000262358 ITGAE
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GSG2 on UCSC Golden Path with GeneCards custom track

Promoters for GSG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001339308 -103 2001 HDGF CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for GSG2 Gene

Chromosome:
17
Start:
3,723,903 bp from pter
End:
3,726,699 bp from pter
Size:
2,797 bases
Orientation:
Plus strand

Genomic View for GSG2 Gene

Genes around GSG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSG2 Gene

Proteins for GSG2 Gene

  • Protein details for GSG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF76-HASP_HUMAN
    Recommended name:
    Serine/threonine-protein kinase haspin
    Protein Accession:
    Q8TF76
    Secondary Accessions:
    • Q5U5K3
    • Q96MN1
    • Q9BXS7

    Protein attributes for GSG2 Gene

    Size:
    798 amino acids
    Molecular mass:
    88495 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GSG2 Gene

    Alternative splice isoforms for GSG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSG2 Gene

Post-translational modifications for GSG2 Gene

  • Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at Ser-3 in mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSG2 Gene

Domains & Families for GSG2 Gene

Gene Families for GSG2 Gene

Protein Domains for GSG2 Gene

Suggested Antigen Peptide Sequences for GSG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF76

UniProtKB/Swiss-Prot:

HASP_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
genes like me logo Genes that share domains with GSG2: view

Function for GSG2 Gene

Molecular function for GSG2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutive activity that does not require phosphorylation. Specifically inhibited by 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine (CHR-6494).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that phosphorylates histone H3 at Thr-3 (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Enzyme Numbers (IUBMB) for GSG2 Gene

Gene Ontology (GO) - Molecular Function for GSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 11228240
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 22939624
GO:0005524 ATP binding IDA 11228240
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with GSG2: view
genes like me logo Genes that share phenotypes with GSG2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSG2

miRNA for GSG2 Gene

miRTarBase miRNAs that target GSG2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GSG2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSG2 Gene

Localization for GSG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSG2 Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSG2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11228240
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005813 centrosome IDA 11228240
GO:0005819 spindle IEA,IDA 15681610
genes like me logo Genes that share ontologies with GSG2: view

Pathways & Interactions for GSG2 Gene

No Data Available

Pathways by source for GSG2 Gene

1 GeneTex pathway for GSG2 Gene

Gene Ontology (GO) - Biological Process for GSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11228240
GO:0007049 cell cycle IEA --
GO:0007064 mitotic sister chromatid cohesion IMP 20705812
GO:0016310 phosphorylation IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with GSG2: view

No data available for SIGNOR curated interactions for GSG2 Gene

Drugs & Compounds for GSG2 Gene

(7) Drugs for GSG2 Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol Experimental Pharma Target 0
3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine Experimental Pharma Target 0
5-iodotubercidin Experimental Pharma Target Adenosine kinase inhibitor,potent, Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 0
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE Experimental Pharma Target 0
LDN 209929 dihydrochloride Pharma Haspin kinase inhibitor,potent and selective, Potent and selective haspin inhibitor 0

(1) Additional Compounds for GSG2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CHR 6494 trifluoroacetate
1458630-17-5

(2) Tocris Compounds for GSG2 Gene

Compound Action Cas Number
CHR 6494 trifluoroacetate Potent and selective haspin inhibitor 1458630-17-5
LDN 209929 dihydrochloride Potent and selective haspin inhibitor

(2) ApexBio Compounds for GSG2 Gene

Compound Action Cas Number
CHR-6494 Haspin inhibitor,potent ands selective 1333377-65-3
LDN 209929 dihydrochloride Haspin kinase inhibitor,potent and selective
genes like me logo Genes that share compounds with GSG2: view

Transcripts for GSG2 Gene

mRNA/cDNA for GSG2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSG2 Gene

Germ cell associated 2 (haspin):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GSG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSG2 Gene

No ASD Table

Relevant External Links for GSG2 Gene

GeneLoc Exon Structure for
GSG2
ECgene alternative splicing isoforms for
GSG2

Expression for GSG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSG2 Gene

mRNA expression in normal human tissues for GSG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSG2 Gene



Protein tissue co-expression partners for GSG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSG2 Gene:

GSG2

SOURCE GeneReport for Unigene cluster for GSG2 Gene:

Hs.534059

mRNA Expression by UniProt/SwissProt for GSG2 Gene:

Q8TF76-HASP_HUMAN
Tissue specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
genes like me logo Genes that share expression patterns with GSG2: view

Primer Products

No data available for mRNA differential expression in normal tissues for GSG2 Gene

Orthologs for GSG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSG2 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia GSG2 34 35
  • 82.05 (n)
cow
(Bos Taurus)
Mammalia GSG2 34 35
  • 80.77 (n)
mouse
(Mus musculus)
Mammalia Gsg2 34 16 35
  • 74.64 (n)
rat
(Rattus norvegicus)
Mammalia Gsg2 34
  • 74.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GSG2 35
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GSG2 35
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Haspin 36 35
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea F22H10.5 36 35
  • 37 (a)
Y40A1A.1 35
  • 33 (a)
OneToMany
Y18H1A.10 35
  • 28 (a)
OneToMany
C01H6.9 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8655 35
  • 39 (a)
OneToOne
Species where no ortholog for GSG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSG2 Gene

ENSEMBL:
Gene Tree for GSG2 (if available)
TreeFam:
Gene Tree for GSG2 (if available)

Paralogs for GSG2 Gene

No data available for Paralogs for GSG2 Gene

Variants for GSG2 Gene

Sequence variations from dbSNP and Humsavar for GSG2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111269600 -- 3,723,787(+) CCAAG(A/C)CGCCA intron-variant, upstream-variant-2KB
rs111318456 -- 3,726,720(+) CCCTC(-/T)TTTTT intron-variant, downstream-variant-500B
rs112585953 -- 3,722,370(+) CAGCT(A/G)CTCGG intron-variant, upstream-variant-2KB
rs112953997 -- 3,726,900(+) GTTTG(-/T)ATTTT intron-variant, downstream-variant-500B
rs113129718 -- 3,721,953(+) GGAGG(A/G)CGGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GSG2 Gene

Variant ID Type Subtype PubMed ID
nsv1055740 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv469791 CNV loss 16826518
nsv574237 CNV loss 21841781
nsv833342 CNV loss 17160897

Variation tolerance for GSG2 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSG2 Gene

Disorders for GSG2 Gene

Relevant External Links for GSG2

Human Genome Epidemiology (HuGE) Navigator
GSG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSG2

No disorders were found for GSG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSG2 Gene

Publications for GSG2 Gene

  1. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. (PMID: 17084365) Dai J. … Higgins J.M. (Dev. Cell 2006) 3 4 22 64
  2. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. (PMID: 15681610) Dai J. … Higgins J.M.G. (Genes Dev. 2005) 3 4 22 64
  3. Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase. (PMID: 11228240) Tanaka H. … Nishimune Y. (Mol. Hum. Reprod. 2001) 3 4 22 64
  4. The Haspin gene: location in an intron of the Integrin Alpha-E gene, associated transcription of an Integrin alpha-E-derived RNA and expression in diploid as well as haploid cells. (PMID: 11311556) Higgins J.M.G. (Gene 2001) 3 4 22 64
  5. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. (PMID: 21658950) Wang F. … Higgins J.M. (Curr. Biol. 2011) 3 4 64

Products for GSG2 Gene

Sources for GSG2 Gene

Content
Loading form....