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Aliases for GSG2 Gene

Aliases for GSG2 Gene

  • Germ Cell Associated 2, Haspin 2 3
  • Germ Cell Associated 2 (Haspin) 2 3 5
  • Haploid Germ Cell-Specific Nuclear Protein Kinase 3 4
  • Germ Cell-Specific Gene 2 Protein 3 4
  • H-Haspin 3 4
  • EC 2.7.11.1 4
  • HASPIN 3

External Ids for GSG2 Gene

Previous GeneCards Identifiers for GSG2 Gene

  • GC17P003939
  • GC17P003578
  • GC17P003833
  • GC17P003573
  • GC17P003517
  • GC17P003627

Summaries for GSG2 Gene

GeneCards Summary for GSG2 Gene

GSG2 (Germ Cell Associated 2, Haspin) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for GSG2 Gene

  • Serine/threonine-protein kinase that phosphorylates histone H3 at Ser-3 (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Tocris Summary for GSG2 Gene

Gene Wiki entry for GSG2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSG2 Gene

Genomics for GSG2 Gene

Regulatory Elements for GSG2 Gene

Enhancers for GSG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSG2 on UCSC Golden Path with GeneCards custom track

Promoters for GSG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GSG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSG2 Gene

Chromosome:
17
Start:
3,723,903 bp from pter
End:
3,726,699 bp from pter
Size:
2,797 bases
Orientation:
Plus strand

Genomic View for GSG2 Gene

Genes around GSG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSG2 Gene

Proteins for GSG2 Gene

  • Protein details for GSG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF76-HASP_HUMAN
    Recommended name:
    Serine/threonine-protein kinase haspin
    Protein Accession:
    Q8TF76
    Secondary Accessions:
    • Q5U5K3
    • Q96MN1
    • Q9BXS7

    Protein attributes for GSG2 Gene

    Size:
    798 amino acids
    Molecular mass:
    88495 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GSG2 Gene

    Alternative splice isoforms for GSG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSG2 Gene

Proteomics data for GSG2 Gene at MOPED

Post-translational modifications for GSG2 Gene

  • Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at Ser-3 in mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSG2 Gene

Domains & Families for GSG2 Gene

Gene Families for GSG2 Gene

Protein Domains for GSG2 Gene

Suggested Antigen Peptide Sequences for GSG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF76

UniProtKB/Swiss-Prot:

HASP_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
genes like me logo Genes that share domains with GSG2: view

Function for GSG2 Gene

Molecular function for GSG2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutive activity that does not require phosphorylation. Specifically inhibited by 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine (CHR-6494).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that phosphorylates histone H3 at Ser-3 (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Enzyme Numbers (IUBMB) for GSG2 Gene

Gene Ontology (GO) - Molecular Function for GSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 11228240
genes like me logo Genes that share ontologies with GSG2: view
genes like me logo Genes that share phenotypes with GSG2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSG2

miRNA for GSG2 Gene

miRTarBase miRNAs that target GSG2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSG2 Gene

Localization for GSG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSG2 Gene

Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSG2 Gene COMPARTMENTS Subcellular localization image for GSG2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11228240
GO:0005819 spindle IDA 15681610
genes like me logo Genes that share ontologies with GSG2: view

Pathways & Interactions for GSG2 Gene

SuperPathways for GSG2 Gene

No Data Available

Pathways by source for GSG2 Gene

1 GeneTex pathway for GSG2 Gene

Gene Ontology (GO) - Biological Process for GSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090231 regulation of spindle checkpoint IMP 20705812
GO:2000751 histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore IMP 23071153
genes like me logo Genes that share ontologies with GSG2: view

No data available for SIGNOR curated interactions for GSG2 Gene

Drugs & Compounds for GSG2 Gene

(5) Drugs for GSG2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol Experimental Pharma Target 0
3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine Experimental Pharma Target 0
5-iodotubercidin Experimental Pharma Target Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 0
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE Experimental Pharma Target 0
Magnesium Nutra 0

(2) Additional Compounds for GSG2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CHR 6494 trifluoroacetate
1458630-17-5
LDN 209929 dihydrochloride

(2) Tocris Compounds for GSG2 Gene

Compound Action Cas Number
CHR 6494 trifluoroacetate Potent and selective haspin inhibitor 1458630-17-5
LDN 209929 dihydrochloride Potent and selective haspin inhibitor
genes like me logo Genes that share compounds with GSG2: view

Transcripts for GSG2 Gene

mRNA/cDNA for GSG2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSG2 Gene

Germ cell associated 2 (haspin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSG2 Gene

No ASD Table

Relevant External Links for GSG2 Gene

GeneLoc Exon Structure for
GSG2
ECgene alternative splicing isoforms for
GSG2

Expression for GSG2 Gene

mRNA expression in normal human tissues for GSG2 Gene

mRNA expression in normal human tissues for GSG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSG2 Gene



SOURCE GeneReport for Unigene cluster for GSG2 Gene Hs.534059

mRNA Expression by UniProt/SwissProt for GSG2 Gene

Q8TF76-HASP_HUMAN
Tissue specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
genes like me logo Genes that share expression patterns with GSG2: view

Protein tissue co-expression partners for GSG2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for GSG2 Gene

Orthologs for GSG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSG2 35
  • 80.77 (n)
  • 72.44 (a)
GSG2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSG2 35
  • 82.05 (n)
  • 74.49 (a)
GSG2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsg2 35
  • 74.64 (n)
  • 64.44 (a)
Gsg2 16
Gsg2 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GSG2 35
  • 99.37 (n)
  • 98.62 (a)
GSG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsg2 35
  • 74.52 (n)
  • 65.73 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GSG2 36
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GSG2 36
  • 23 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Haspin 37
  • 40 (a)
Haspin 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F22H10.5 37
  • 37 (a)
C01H6.9 36
  • 19 (a)
OneToMany
F22H10.5 36
  • 33 (a)
OneToMany
Y18H1A.10 36
  • 28 (a)
OneToMany
Y40A1A.1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8655 36
  • 39 (a)
OneToOne
Species with no ortholog for GSG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSG2 Gene

ENSEMBL:
Gene Tree for GSG2 (if available)
TreeFam:
Gene Tree for GSG2 (if available)

Paralogs for GSG2 Gene

No data available for Paralogs for GSG2 Gene

Variants for GSG2 Gene

Sequence variations from dbSNP and Humsavar for GSG2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_027405 -
VAR_027406 -
VAR_027407 -
VAR_027408 -
VAR_040540 -

Structural Variations from Database of Genomic Variants (DGV) for GSG2 Gene

Variant ID Type Subtype PubMed ID
nsv833342 CNV Loss 17160897
nsv907570 CNV Gain 21882294
nsv469791 CNV Complex 16826518

Variation tolerance for GSG2 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GSG2 Gene

Disorders for GSG2 Gene

Relevant External Links for GSG2

Human Genome Epidemiology (HuGE) Navigator
GSG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSG2

No disorders were found for GSG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSG2 Gene

Publications for GSG2 Gene

  1. Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase. (PMID: 11228240) Tanaka H. … Nishimune Y. (Mol. Hum. Reprod. 2001) 3 4 23 67
  2. Haspin: a newly discovered regulator of mitotic chromosome behavior. (PMID: 19997740) Higgins J.M. (Chromosoma 2010) 3 23
  3. Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. (PMID: 19910498) Dai J. … Higgins J.M. (J. Cell. Sci. 2009) 3 23
  4. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. (PMID: 17084365) Dai J. … Higgins J.M. (Dev. Cell 2006) 3 23
  5. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. (PMID: 15681610) Dai J. … Higgins J.M.G. (Genes Dev. 2005) 3 23

Products for GSG2 Gene

Sources for GSG2 Gene

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