Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSG2 Gene

protein-coding   GIFtS: 56
GCID: GC17P003627

Germ Cell Associated 2 (Haspin)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Germ Cell Associated 2 (Haspin)1 2     HASPIN2
Germ Cell-Specific Gene 2 Protein2 3     Serine/Threonine-Protein Kinase Haspin2
Haploid Germ Cell-Specific Nuclear Protein Kinase2 3     EC 2.7.11.13
H-haspin2 3     

External Ids:    HGNC: 196821   Entrez Gene: 839032   Ensembl: ENSG000001776027   OMIM: 6092405   UniProtKB: Q8TF763   

Export aliases for GSG2 gene to outside databases

Previous GC identifers: GC17P003939 GC17P003578 GC17P003833 GC17P003573 GC17P003517


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for GSG2 Gene: 
GSG2 (germ cell associated 2 (haspin)) is a protein-coding gene. Diseases associated with GSG2 include rhinotracheitis, and mouth disease. GO annotations related to this gene include protein kinase activity and histone kinase activity (H3-T3 specific).

UniProtKB/Swiss-Prot: HASP_HUMAN, Q8TF76
Function: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This
positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to
ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle

Gene Wiki entry for GSG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for GSG2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGSG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for GSG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

GSG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSG2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P003627:  view genomic region     (about GC identifiers)

Start:
3,627,197 bp from pter      End:
3,630,067 bp from pter
Size:
2,871 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HASP_HUMAN, Q8TF76 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase haspin  
Size: 798 amino acids; 88495 Da
Cofactor: Magnesium
Subcellular location: Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and
associates with the chromosomes and spindle apparatus during mitosis
6/7 PDB 3D structures from and Proteopedia for GSG2 (see all 7):
2VUW (3D)        2WB8 (3D)        3DLZ (3D)        3E7V (3D)        3F2N (3D)        3FMD (3D)    
Secondary accessions: Q5U5K3 Q96MN1 Q9BXS7
Alternative splicing: 2 isoforms:  Q8TF76-1   Q8TF76-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GSG2: NX_Q8TF76

Explore proteomics data for GSG2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis
    but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is
    required for full activity toward histone H3 at 'Ser-3' in mitosis
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF76

  • GSG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GSG2 Protein Expression
    REFSEQ proteins: NP_114171.2  
    ENSEMBL proteins: 
     ENSP00000325290  

    Human Recombinant Protein Products for GSG2: 
    EMD Millipore Purified and/or Recombinant GSG2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GSG2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GSG2
    GenScript Custom Purified and Recombinant Proteins Services for GSG2
    Novus Biologicals GSG2 Proteins
    Novus Biologicals GSG2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GSG2 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA11228240
    GO:0005819spindle IDA15681610

    GSG2 for ontologies           About GeneDecksing



    GSG2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GSG2
    GenScript Custom Superior Antibodies Services for GSG2
    Novus Biologicals GSG2 Antibodies
    Abcam antibodies for GSG2
    Cloud-Clone Corp. Antibodies for GSG2 
    ThermoFisher Antibodies for GSG2
    LSBio Antibodies in human, mouse, rat for GSG2 

    Assay Products for GSG2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GSG2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GSG2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GSG2 
    Cloud-Clone Corp. CLIAs for GSG2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: germ cell associated 2 (haspin) 
    Haspin family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR024604 DUF3635
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8TF76

    ProtoNet protein and cluster: Q8TF76

    UniProtKB/Swiss-Prot: HASP_HUMAN, Q8TF76
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily
    Similarity: Contains 1 protein kinase domain


    GSG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HASP_HUMAN, Q8TF76
    Function: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This
    positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to
    ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Constitutive activity that does not require phosphorylation. Specifically inhibited by
    3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine (CHR-6494)

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity IDA11228240
    GO:0004674protein serine/threonine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IDA11228240
         
    GSG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GSG2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GSG2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSG2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSG2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSG2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate GSG2:
    hsa-miR-4261 hsa-miR-491-5p hsa-miR-3065-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidGSG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GSG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GSG2
    Sirion Biotech Customized adenovirus for overexpression of GSG2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GSG2 (see all 7)
    OriGene ORF clones in mouse, rat for GSG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSG2 (NM_031965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSG2
    Sirion Biotech Customized lentivirus for stable overexpression of GSG2 
                         Customized lentivirus expression plasmids for stable overexpression of GSG2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GSG2
    Search LifeMap BioReagents cell lines for GSG2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSG2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GSG2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/14 Interacting proteins for GSG2 (Q8TF761, 2, 3 ENSP000003252904) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11228240
    GO:0007049cell cycle ----
    GO:0007064mitotic sister chromatid cohesion IMP--
    GO:0007243intracellular protein kinase cascade IDA11228240
    GO:0071459protein localization to chromosome, centromeric region IMP--

    GSG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSG2 (HASP)

    1 HMDB Compound for GSG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 DrugBank Compounds for GSG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol-- --target--10592235
    3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine-- --target--10592235
    5-iodotubercidin-- 24386-93-4target--10592235
    N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about GSG2 / HASP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GSG2 gene: 
    NM_031965.2  

    Unigene Cluster for GSG2:

    Germ cell associated 2 (haspin)
    Hs.534059  [show with all ESTs]
    Unigene Representative Sequence: AK292715
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000325418(uc002fwp.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSG2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate GSG2:
    hsa-miR-4261 hsa-miR-491-5p hsa-miR-3065-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidGSG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GSG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSG2
    Clone
    Products:
         
    OriGene clones in human, mouse for GSG2 (see all 7)
    OriGene ORF clones in mouse, rat for GSG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GSG2 (NM_031965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSG2
    Sirion Biotech Customized lentivirus for stable overexpression of GSG2 
                         Customized lentivirus expression plasmids for stable overexpression of GSG2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GSG2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GSG2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSG2

    Additional mRNA sequence: 

    AB039834.3 AF289865.1 AK292715.1 AK310546.1 AK315247.1 BC016626.1 BC036181.1 BC047457.1 

    3 DOTS entries:

    DT.40272358  DT.95270360  DT.100735073 

    24/29 AceView cDNA sequences (see all 29):

    BM458397 BM013960 BC036181 CR615999 AK056691 AA504563 BI562569 BC047457 
    NM_031965 AB039834 AA504486 AL530641 BC016626 BX103601 BM838281 AF289865 
    AL530642 BG025225 BG390073 BI562471 AW752339 AW405732 AA765234 BM152111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSG2 expression in normal human tissues (normalized intensities)      GSG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCAAAAAA
    GSG2 Expression
    About this image


    GSG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See GSG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSG2

    SOURCE GeneReport for Unigene cluster: Hs.534059

    UniProtKB/Swiss-Prot: HASP_HUMAN, Q8TF76
    Tissue specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed
    in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine
    and also in proliferating but not non-proliferating cell lines

        SABiosciences Custom PCR Arrays for GSG2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GSG2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GSG2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSG2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GSG2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gsg21 , 5 germ cell-specific gene 21, 5 75.79(n)1
    65.6(a)1
      11 (45.25 cM)5
    148411  NM_010353.21  NP_034483.11 
     731354855 
    chicken
    (Gallus gallus)
    Aves GSG21 germ cell associated 2 (haspin) 52.73(n)
    46.48(a)
      427834  XM_425408.2  XP_425408.2 
    zebrafish
    (Danio rerio)
    Actinopterygii GSG26
    germ cell associated 2 (haspin)
    25(a)
    1 ↔ 1
    1(22263363-22280628)
    fruit fly
    (Drosophila melanogaster)
    Insecta Haspin3 protein serine/threonine kinase 40(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F22H10.53   -- 37(a)   X(16717006-16717976)   --


    ENSEMBL Gene Tree for GSG2 (if available)
    TreeFam Gene Tree for GSG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10 SNPs in GSG2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0405434
    ----see VAR_0405432 G S mis40--------
    VAR_0274084
    ----see VAR_0274082 N D mis40--------
    VAR_0405454
    ----see VAR_0405452 M V mis40--------
    VAR_0405444
    ----see VAR_0405442 Q L mis40--------
    VAR_0274054
    ----see VAR_0274052 G D mis40--------
    VAR_0274074
    ----see VAR_0274072 V A mis40--------
    VAR_0405404
    ----see VAR_0405402 V E mis40--------
    VAR_0405414
    ----see VAR_0405412 R C mis40--------
    VAR_0274064
    ----see VAR_0274062 I T mis40--------
    VAR_0405424
    ----see VAR_0405422 R H mis40--------

    HapMap Linkage Disequilibrium report for GSG2 (3627197 - 3630067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GSG2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833342CNV Loss17160897
    nsv907570CNV Gain21882294
    nsv469791CNV Complex16826518

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GSG2
    DNA2.0 Custom Variant and Variant Library Synthesis for GSG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609240    OMIM disorders: --

    5 diseases for GSG2:    About MalaCards
    rhinotracheitis    mouth disease    hepatitis b    hepatitis
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for GSG2:
    Rhinotracheitis

    GSG2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: GSG2 (1 document)

    Export disorders for GSG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSG2 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with GSG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase. (PubMed id 11228240)1, 2, 9 Tanaka H....Nishimune Y. (2001)
    2. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. (PubMed id 17084365)1, 2, 9 Dai J....Higgins J.M. (2006)
    3. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. (PubMed id 15681610)1, 2, 9 Dai J.... Higgins J.M.G. (2005)
    4. The Haspin gene: location in an intron of the Integrin Alpha-E gene, associated transcription of an Integrin alpha-E-derived RNA and expression in diploid as well as haploid cells. (PubMed id 11311556)1, 2, 9 Higgins J.M.G. (2001)
    5. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. (PubMed id 21658950)1, 2 Wang F....Higgins J.M. (2011)
    6. Two histone marks establish the inner centromere and chromosome bi-orientation. (PubMed id 20929775)1, 2 Yamagishi Y....Watanabe Y. (2010)
    7. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. (PubMed id 20705812)1, 2 Wang F....Higgins J.M. (2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Haspin: a newly discovered regulator of mitotic chrom osome behavior. (PubMed id 19997740)1, 9 Higgins J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83903 HGNC: 19682 AceView: GSG2 Ensembl:ENSG00000177602 euGenes: HUgn83903
    ECgene: GSG2 H-InvDB: GSG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GSG2 gene:
    Search GeneIP for patents involving GSG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant GSG2 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GSG2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GSG2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GSG2  
     OriGene qSTAR qPCR primer pairs in human, mouse for GSG2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GSG2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GSG2   OriGene Custom Protein Services for GSG2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSG2
     QIAGEN SeqTarget long-range PCR primers for resequencing GSG2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSG2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSG2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSG2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSG2
     GenScript Custom Purified and Recombinant Proteins Services for GSG2 GenScript cDNA clones with any tag delivered in your preferred vector for GSG2
     GenScript Custom Assay Services for GSG2 GenScript Custom Superior Antibodies Services for GSG2
     GenScript Custom overexpressing Cell Line Services for GSG2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for GSG2
     Search Chromatin IP Primers for GSG2
     RT2 qPCR Primer Assay in human, mouse, rat GSG2
     Search GNC Networks for GSG2
     SABiosciences Custom PCR Arrays for GSG2
     Search Tocris compounds for GSG2 (HASP)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GSG2 antibodies
     GSG2 proteins
     GSG2 lysates
     Antibodies for GSG2
     See all of Abcam's Antibodies, Kits and Proteins for GSG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GSG2
     Antibodies for GSG2
     ELISAs for GSG2
     CLIAs for GSG2
     Search LifeMap BioReagents cell lines for GSG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSG2
     SwitchGear 3'UTR luciferase reporter plasmids for GSG2
     SwitchGear Promoter luciferase reporter plasmids for GSG2
     ThermoFisher Antibodies for GSG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSG2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GSG2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSG2
    Customized:
     lentivirus for stable overexpression of GSG2
     lentivirus expression plasmids for stable overexpression of GSG2
     adenovirus for overexpression of GSG2
     LSBio Antibodies in human, mouse, rat for GSG2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GSG2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4