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Aliases for GSG1 Gene

Aliases for GSG1 Gene

  • Germ Cell Associated 1 2 3 5

External Ids for GSG1 Gene

Previous GeneCards Identifiers for GSG1 Gene

  • GC12M012968
  • GC12M013381
  • GC12M013136
  • GC12M013127
  • GC12M013237
  • GC12M013007

Summaries for GSG1 Gene

GeneCards Summary for GSG1 Gene

GSG1 (Germ Cell Associated 1) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase binding. An important paralog of this gene is GSG1L.

UniProtKB/Swiss-Prot for GSG1 Gene

  • May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSG1 Gene

Genomics for GSG1 Gene

Regulatory Elements for GSG1 Gene

Enhancers for GSG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GSG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GSG1 Gene

13,083,537 bp from pter
13,103,720 bp from pter
20,184 bases
Minus strand

Genomic View for GSG1 Gene

Genes around GSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSG1 Gene

Proteins for GSG1 Gene

  • Protein details for GSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Germ cell-specific gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • Q8N4M3
    • Q8NBR4
    • Q8NBS0
    • Q8NBT1
    • Q96LP9
    • Q96SI6
    • Q9BUY4

    Protein attributes for GSG1 Gene

    349 amino acids
    Molecular mass:
    39248 Da
    Quaternary structure:
    • Interacts with PAPOLB.
    • Sequence=AAH01796.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33854.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GSG1 Gene

neXtProt entry for GSG1 Gene

Proteomics data for GSG1 Gene at MOPED

Post-translational modifications for GSG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GSG1 Gene

Domains & Families for GSG1 Gene

Protein Domains for GSG1 Gene


Suggested Antigen Peptide Sequences for GSG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GSG1 family.
  • Belongs to the GSG1 family.
genes like me logo Genes that share domains with GSG1: view

No data available for Gene Families for GSG1 Gene

Function for GSG1 Gene

Molecular function for GSG1 Gene

UniProtKB/Swiss-Prot Function:
May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.

Gene Ontology (GO) - Molecular Function for GSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GSG1: view
genes like me logo Genes that share phenotypes with GSG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSG1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSG1 Gene

Localization for GSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSG1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with PAPOLB in the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for GSG1 Gene COMPARTMENTS Subcellular localization image for GSG1 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 3
extracellular 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for GSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GSG1: view

Pathways & Interactions for GSG1 Gene

SuperPathways for GSG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GSG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for GSG1 Gene

Drugs & Compounds for GSG1 Gene

No Compound Related Data Available

Transcripts for GSG1 Gene

Unigene Clusters for GSG1 Gene

Germ cell associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSG1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - -

Relevant External Links for GSG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSG1 Gene

mRNA expression in normal human tissues for GSG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSG1 Gene

This gene is overexpressed in Testis (x50.2).

Protein differential expression in normal tissues from HIPED for GSG1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GSG1 Gene

SOURCE GeneReport for Unigene cluster for GSG1 Gene Hs.240053

genes like me logo Genes that share expression patterns with GSG1: view

Protein tissue co-expression partners for GSG1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GSG1 Gene

Orthologs for GSG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GSG1 35
  • 82.71 (n)
  • 75.31 (a)
GSG1 36
  • 66 (a)
(Canis familiaris)
Mammalia GSG1 35
  • 85.64 (n)
  • 79.65 (a)
GSG1 36
  • 68 (a)
(Mus musculus)
Mammalia Gsg1 35
  • 81.73 (n)
  • 74.92 (a)
Gsg1 16
Gsg1 36
  • 64 (a)
(Pan troglodytes)
Mammalia GSG1 35
  • 98.9 (n)
  • 98.62 (a)
GSG1 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Gsg1 35
  • 81.21 (n)
  • 74.78 (a)
(Monodelphis domestica)
Mammalia GSG1 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia GSG1 36
  • 55 (a)
(Gallus gallus)
Aves GSG1 35
  • 69.85 (n)
  • 62.15 (a)
GSG1 36
  • 62 (a)
(Anolis carolinensis)
Reptilia GSG1 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490751 35
  • 63.64 (n)
  • 61.04 (a)
(Danio rerio)
Actinopterygii GSG1 36
  • 21 (a)
Species with no ortholog for GSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSG1 Gene

Gene Tree for GSG1 (if available)
Gene Tree for GSG1 (if available)

Paralogs for GSG1 Gene

Paralogs for GSG1 Gene

(1) SIMAP similar genes for GSG1 Gene using alignment to 9 proteins: Pseudogenes for GSG1 Gene

genes like me logo Genes that share paralogs with GSG1: view

Variants for GSG1 Gene

Sequence variations from dbSNP and Humsavar for GSG1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2306765 - 13,090,713(-) ACTGG(C/T)TTGTG reference, missense
rs11546332 - 13,090,628(-) GGATG(G/T)AGATA reference, missense
rs17212998 -- 13,090,234(+) ATGCT(A/G)TTTTG intron-variant
rs17759413 -- 13,093,276(+) ATAAT(C/T)GTTTT intron-variant
rs17820032 -- 13,095,223(+) AGGGT(C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSG1 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv832333 CNV Gain 17160897

Variation tolerance for GSG1 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.13; 69.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for GSG1 Gene

Disorders for GSG1 Gene

Relevant External Links for GSG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSG1 Gene

Publications for GSG1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for GSG1 Gene

Sources for GSG1 Gene