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Aliases for GSE1 Gene

Aliases for GSE1 Gene

  • Gse1 Coiled-Coil Protein 2 3 5
  • KIAA0182 2 3 4
  • Genetic Suppressor Element 1 2 3
  • Gse1 Coiled-Coil Protein Homolog (Mouse) 2
  • Gse1 Coiled-Coil Protein Homolog 3
  • CTC-786C10.1 3
  • CRHSP24 3

External Ids for GSE1 Gene

Previous HGNC Symbols for GSE1 Gene

  • KIAA0182

Previous GeneCards Identifiers for GSE1 Gene

  • GC16P085646

Summaries for GSE1 Gene

GeneCards Summary for GSE1 Gene

GSE1 (Gse1 Coiled-Coil Protein) is a Protein Coding gene. Diseases associated with GSE1 include Central Nervous System Primitive Neuroectodermal Neoplasm.

Gene Wiki entry for GSE1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSE1 Gene

Genomics for GSE1 Gene

Regulatory Elements for GSE1 Gene

Enhancers for GSE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F085582 1 Ensembl ENCODE 23.1 +413.8 413791 2.6 HDGF ATF1 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF48 GLIS2 GSE1 ENSG00000270184 GINS2 RNU1-103P ZDHHC7 LOC105371384 GC16P085552
GH16F085550 1.4 FANTOM5 Ensembl ENCODE 22.9 +394.8 394849 27.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000270184 RNU1-103P KLHL36 ZDHHC7 GSE1 RN7SL381P ENSG00000269898 ENSG00000261177 ENSG00000269826 ENSG00000260859
GH16F085578 1.3 Ensembl ENCODE 21.8 +409.9 409880 2.4 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 GSE1 ENSG00000269898 ENSG00000261177 ENSG00000269826 GINS2 USP10 LOC105371384 GC16P085552
GH16F085585 1.4 VISTA Ensembl ENCODE 13.2 +417.5 417535 2.9 HDGF ATF1 MLX ARID4B YY1 SP5 MIER2 REST PPARG KAT8 GSE1 GINS2 LOC105371384 ENSG00000260417
GH16F085590 0.8 FANTOM5 13.2 +420.8 420769 0.4 HDGF YBX1 CDC5L ZBTB40 ZFHX2 POLR2A SCRT2 TRIM24 ZSCAN29 KDM4B GSE1 GINS2 ENSG00000260417 LOC105371384
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GSE1 on UCSC Golden Path with GeneCards custom track

Promoters for GSE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001803582 75 1601 SUZ12 CREB3L1 THRB ZIC2 RARA E2F1 POLR2A E2F6 L3MBTL2 RNF2

Genomic Location for GSE1 Gene

Chromosome:
16
Start:
85,169,525 bp from pter
End:
85,676,206 bp from pter
Size:
506,682 bases
Orientation:
Plus strand

Genomic View for GSE1 Gene

Genes around GSE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSE1 Gene

Proteins for GSE1 Gene

  • Protein details for GSE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14687-GSE1_HUMAN
    Recommended name:
    Genetic suppressor element 1
    Protein Accession:
    Q14687
    Secondary Accessions:
    • D3DUM4
    • Q8IY61
    • Q96GA4
    • Q9BW09

    Protein attributes for GSE1 Gene

    Size:
    1217 amino acids
    Molecular mass:
    136164 Da
    Quaternary structure:
    • May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
    SequenceCaution:
    • Sequence=BAA11499.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GSE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSE1 Gene

Post-translational modifications for GSE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GSE1 Gene

Domains & Families for GSE1 Gene

Protein Domains for GSE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GSE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GSE1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GSE1 Gene

Function for GSE1 Gene

Molecular function for GSE1 Gene

UniProtKB/Swiss-Prot Induction:
Negatively regulated by miR-489-5p.

Gene Ontology (GO) - Molecular Function for GSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GSE1: view
genes like me logo Genes that share phenotypes with GSE1: view

Animal Models for GSE1 Gene

MGI Knock Outs for GSE1:
  • Gse1 tm1a(EUCOMM)Wtsi

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSE1 Gene

Localization for GSE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSE1 Gene COMPARTMENTS Subcellular localization image for GSE1 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GSE1 Gene

Pathways & Interactions for GSE1 Gene

SuperPathways for GSE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GSE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GSE1 Gene

Transcripts for GSE1 Gene

Unigene Clusters for GSE1 Gene

Gse1 coiled-coil protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSE1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: - - - - -
SP3:
SP4: -
SP5:
SP6:
SP7:

Relevant External Links for GSE1 Gene

GeneLoc Exon Structure for
GSE1
ECgene alternative splicing isoforms for
GSE1

Expression for GSE1 Gene

mRNA expression in normal human tissues for GSE1 Gene

Protein differential expression in normal tissues from HIPED for GSE1 Gene

This gene is overexpressed in Cervix (31.9), Placenta (18.2), and Monocytes (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSE1 Gene



Protein tissue co-expression partners for GSE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GSE1 Gene:

GSE1

SOURCE GeneReport for Unigene cluster for GSE1 Gene:

Hs.461647
genes like me logo Genes that share expression patterns with GSE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GSE1 Gene

Orthologs for GSE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSE1 34 35
  • 97.58 (n)
dog
(Canis familiaris)
Mammalia GSE1 35
  • 91 (a)
OneToOne
KIAA0182 34
  • 88.76 (n)
cow
(Bos Taurus)
Mammalia GSE1 35
  • 89 (a)
OneToOne
KIAA0182 34
  • 86.08 (n)
rat
(Rattus norvegicus)
Mammalia Gse1 34
  • 84.47 (n)
mouse
(Mus musculus)
Mammalia Gse1 34 16 35
  • 84.19 (n)
oppossum
(Monodelphis domestica)
Mammalia GSE1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GSE1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves GSE1 35
  • 76 (a)
OneToOne
KIAA0182 34
  • 74.77 (n)
lizard
(Anolis carolinensis)
Reptilia GSE1 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gse1 34
  • 61.97 (n)
Str.17615 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1433 34
zebrafish
(Danio rerio)
Actinopterygii gse1 34 35
  • 60.63 (n)
Species where no ortholog for GSE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSE1 Gene

ENSEMBL:
Gene Tree for GSE1 (if available)
TreeFam:
Gene Tree for GSE1 (if available)

Paralogs for GSE1 Gene

(5) SIMAP similar genes for GSE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GSE1: view

No data available for Paralogs for GSE1 Gene

Variants for GSE1 Gene

Sequence variations from dbSNP and Humsavar for GSE1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs757859891 A colorectal cancer sample 85,661,384(+) TGGAG(C/T)GGGTC reference, missense
rs879255401 Likely benign 85,656,484(+) AGCGT(-/GAGAAGGAGCGCGAGCGC)GAGAA cds-indel
rs10048112 -- 85,370,997(+) GGCGG(C/T)GGCTG intron-variant, utr-variant-5-prime
rs10083744 -- 85,198,371(+) TGTTT(C/T)CTAGG intron-variant
rs10083753 -- 85,196,095(+) gggct(C/G)taaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSE1 Gene

Variant ID Type Subtype PubMed ID
esv2714853 CNV deletion 23290073
esv2714854 CNV deletion 23290073
esv27887 CNV loss 19812545
esv4262 OTHER complex 18987735
nsv1071306 CNV deletion 25765185
nsv1144777 CNV deletion 24896259
nsv483044 CNV gain 15286789
nsv515746 CNV loss 19592680
nsv526299 CNV loss 19592680
nsv952062 CNV deletion 24416366

Variation tolerance for GSE1 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.84; 79.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSE1 Gene

Human Gene Mutation Database (HGMD)
GSE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSE1 Gene

Disorders for GSE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GSE1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GSE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSE1
genes like me logo Genes that share disorders with GSE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSE1 Gene

Publications for GSE1 Gene

  1. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
  2. GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion. (PMID: 26828271) Chai P. … Liu B. (Biochem. Biophys. Res. Commun. 2016) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. (PMID: 12493763) Hakimi M.-A. … Shiekhattar R. (J. Biol. Chem. 2003) 3 4 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for GSE1 Gene

Sources for GSE1 Gene

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