Aliases for GSDMD Gene
External Ids for GSDMD Gene
Previous HGNC Symbols for GSDMD Gene
Previous GeneCards Identifiers for GSDMD Gene
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
GeneCards Summary for GSDMD Gene
GSDMD (Gasdermin D) is a Protein Coding gene. An important paralog of this gene is GSDMC.
UniProtKB/Swiss-Prot for GSDMD Gene
Component of inflammasomes responsible for the execution of pyroptosis and the release of mature IL1B. In response to canonical, as well as non-canonical(such as cytosolic LPS) inflammasome activators, undergoes cleavage by inflammatory caspases CASP1 and CASP4, respectively. The released N-terminal moiety promotes pyroptosis and release of mature IL1B.