Aliases for GSDMA Gene
External Ids for GSDMA Gene
Previous HGNC Symbols for GSDMA Gene
Previous GeneCards Identifiers for GSDMA Gene
GeneCards Summary for GSDMA Gene
UniProtKB/Swiss-Prot for GSDMA Gene
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).