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Aliases for GSDMA Gene

Aliases for GSDMA Gene

  • Gasdermin A 2 3
  • Gasdermin 1 2 3
  • Gasdermin-1 3 4
  • GSDM1 3 4
  • GSDM 3 4
  • Gasdermin 2
  • FKSG9 3

External Ids for GSDMA Gene

Previous HGNC Symbols for GSDMA Gene

  • GSDM
  • GSDM1

Previous GeneCards Identifiers for GSDMA Gene

  • GC17P035373
  • GC17P038119
  • GC17P033913

Summaries for GSDMA Gene

GeneCards Summary for GSDMA Gene

GSDMA (Gasdermin A) is a Protein Coding gene. Diseases associated with GSDMA include gastric cancer. An important paralog of this gene is GSDMC.

UniProtKB/Swiss-Prot for GSDMA Gene

  • Induces apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSDMA Gene

Genomics for GSDMA Gene

Regulatory Elements for GSDMA Gene

Genomic Location for GSDMA Gene

Chromosome:
17
Start:
39,962,973 bp from pter
End:
39,977,880 bp from pter
Size:
14,908 bases
Orientation:
Plus strand

Genomic View for GSDMA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSDMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSDMA Gene

Proteins for GSDMA Gene

  • Protein details for GSDMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QA5-GSDMA_HUMAN
    Recommended name:
    Gasdermin-A
    Protein Accession:
    Q96QA5
    Secondary Accessions:
    • Q32MC5
    • Q86VE7
    • Q8N1M6

    Protein attributes for GSDMA Gene

    Size:
    445 amino acids
    Molecular mass:
    49365 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GSDMA Gene

Proteomics data for GSDMA Gene at MOPED

Post-translational modifications for GSDMA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSDMA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSDMA Gene

Domains & Families for GSDMA Gene

Protein Domains for GSDMA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GSDMA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QA5

UniProtKB/Swiss-Prot:

GSDMA_HUMAN :
  • Belongs to the gasdermin family.
Family:
  • Belongs to the gasdermin family.
genes like me logo Genes that share domains with GSDMA: view

No data available for Gene Families for GSDMA Gene

Function for GSDMA Gene

Molecular function for GSDMA Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis.

Phenotypes for GSDMA Gene

GenomeRNAi human phenotypes for GSDMA:
genes like me logo Genes that share phenotypes with GSDMA: view

miRNA for GSDMA Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSDMA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for GSDMA Gene

Localization for GSDMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSDMA Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSDMA Gene COMPARTMENTS Subcellular localization image for GSDMA gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for GSDMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IDA 17471240
genes like me logo Genes that share ontologies with GSDMA: view

Pathways & Interactions for GSDMA Gene

SuperPathways for GSDMA Gene

No Data Available

Interacting Proteins for GSDMA Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301659%0d%0a9606.ENSP00000316578%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000355865%0d%0a
Selected Interacting proteins: Q96QA5-GSDMA_HUMAN ENSP00000301659 for GSDMA Gene via I2D STRING

Gene Ontology (GO) - Biological Process for GSDMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 17471240
genes like me logo Genes that share ontologies with GSDMA: view

No data available for Pathways by source and SIGNOR curated interactions for GSDMA Gene

Drugs & Compounds for GSDMA Gene

No Compound Related Data Available

Transcripts for GSDMA Gene

mRNA/cDNA for GSDMA Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSDMA Gene

Gasdermin A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GSDMA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSDMA Gene

No ASD Table

Relevant External Links for GSDMA Gene

GeneLoc Exon Structure for
GSDMA
ECgene alternative splicing isoforms for
GSDMA

Expression for GSDMA Gene

mRNA expression in normal human tissues for GSDMA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSDMA Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.2) and Skin - Not Sun Exposed (Suprapubic) (x20.4).

Protein differential expression in normal tissues from HIPED for GSDMA Gene

This gene is overexpressed in Saliva (31.5), Urine (10.4), Plasma (9.6), Oral epithelium (8.4), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSDMA Gene



SOURCE GeneReport for Unigene cluster for GSDMA Gene Hs.448873

mRNA Expression by UniProt/SwissProt for GSDMA Gene

Q96QA5-GSDMA_HUMAN
Tissue specificity: Expressed predominantly in the gastrointestinal tract and in the skin at a lower level. Also detected in mammary gland. Detected in mucus-secreting pit cells of the gastric epithelium. Not expressed in gastric cancer cells.
genes like me logo Genes that share expression patterns with GSDMA: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for GSDMA Gene

Orthologs for GSDMA Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSDMA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GSDMA 35
  • 88.69 (n)
  • 89.21 (a)
GSDMA 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GSDMA 35
  • 88.14 (n)
  • 86.23 (a)
GSDMA 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsdma 35
  • 85.69 (n)
  • 88.54 (a)
Gsdma 16
Gsdma 36
  • 88 (a)
OneToMany
Gsdma2 36
  • 76 (a)
OneToMany
Gsdma3 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GSDMA 35
  • 99.33 (n)
  • 99.33 (a)
GSDMA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsdma 35
  • 83.9 (n)
  • 86.52 (a)
oppossum
(Monodelphis domestica)
Mammalia GSDMA 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves GSDMA 35
  • 49.84 (n)
  • 35.41 (a)
GSDMA 36
  • 30 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
Species with no ortholog for GSDMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GSDMA Gene

ENSEMBL:
Gene Tree for GSDMA (if available)
TreeFam:
Gene Tree for GSDMA (if available)

Paralogs for GSDMA Gene

Paralogs for GSDMA Gene

(1) SIMAP similar genes for GSDMA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GSDMA: view

Variants for GSDMA Gene

Sequence variations from dbSNP and Humsavar for GSDMA Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs921651 -- 39,977,669(+) AAAAA(A/G)AAGAT utr-variant-3-prime
rs2001476 -- 39,964,351(+) atcat(C/T)tgagg intron-variant, upstream-variant-2KB
rs2313641 -- 39,972,980(+) AAAAA(A/T)TTTTT intron-variant
rs3859191 -- 39,972,461(+) GGGTG(A/G)ATGAG intron-variant
rs3859192 -- 39,972,395(+) GAGAC(C/T)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSDMA Gene

Variant ID Type Subtype PubMed ID
esv1007042 CNV Gain 20482838

Variation tolerance for GSDMA Gene

Residual Variation Intolerance Score: 89.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.09; 99.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSDMA Gene

HapMap Linkage Disequilibrium report
GSDMA
Human Gene Mutation Database (HGMD)
GSDMA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSDMA Gene

Disorders for GSDMA Gene

MalaCards: The human disease database

(1) MalaCards diseases for GSDMA Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
- elite association
Search GSDMA in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSDMA

Genetic Association Database (GAD)
GSDMA
Human Genome Epidemiology (HuGE) Navigator
GSDMA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GSDMA
genes like me logo Genes that share disorders with GSDMA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSDMA Gene

Publications for GSDMA Gene

  1. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. (PMID: 17350798) Tamura M. … Shiroishi T. (Genomics 2007) 2 23 67
  2. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B- ERBB2-GRB7 amplicon. (PMID: 15010812) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 23 67
  3. Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB). (PMID: 20410667) Komiyama H. … Shiroishi T. (Genes Genet. Syst. 2010) 23 67
  4. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. (PMID: 19051310) Saeki N. … Sasaki H. (Genes Chromosomes Cancer 2009) 23 67
  5. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. (PMID: 17471240) Saeki N. … Sasaki H. (Oncogene 2007) 23 67

Products for GSDMA Gene

Sources for GSDMA Gene

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