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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSC2 Gene

protein-coding GIFtS: 47
GCID: GC22M019136

Goosecoid Homeobox 2

(Previous name: goosecoid-like)
(Previous symbol: GSCL)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Goosecoid Homeobox 2¹ ²		goosecoid-like¹
GSCL¹ ² ³ ⁵		Homeobox Protein Goosecoid-2²
GSC-2² ³		Homeobox Protein Goosecoid-Like³
GSC-L² ³

External Ids:	HGNC: 4613¹	Entrez Gene: 2928²	Ensembl: ENSG00000063515⁷	OMIM: 601845⁵	UniProtKB: O15499³

Export aliases for GSC2 gene to outside databases

Previous GC identifer: GC22M017516

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSC2 Gene:

Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11.

Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects,

craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and

both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures

affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that

haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is

expressed in a limited number of adult tissues, as well as in early human development. (provided by RefSeq, Jul

2008)

GeneCards Summary for GSC2 Gene:

GSC2 (goosecoid homeobox 2) is a protein-coding gene. Diseases associated with GSC2 include velocardiofacial syndrome, and digeorge syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSC.

UniProtKB/Swiss-Prot: GSC2_HUMAN, O15499

Function: May have a role in development. May regulate its own transcription. May bind the bicoid consensus

sequence TAATCC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.2 NT_011519.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSC2 gene promoter:
GATA-1 E47 PPAR-gamma1 IRF-7A AP-2beta PPAR-gamma2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSC2 promoter sequence

Search SABiosciences Chromatin IP Primers for GSC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21

GSC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSC2 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M019136: view genomic region (about GC identifiers)

Start:	19,136,089 bp from pter	End:	19,137,796 bp from pter
Size:	1,708 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSC2_HUMAN, O15499 (See protein sequence)

Recommended Name: Homeobox protein goosecoid-2

Size: 205 amino acids; 21545 Da

Subcellular location: Nucleus (By similarity)

Developmental stage: Expressed in early human development as well as in a limited number of adult tissues

Explore the universe of human proteins at neXtProt for GSC2: NX_O15499

Explore proteomics data for GSC2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_O15499

GSC2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_005306.1

ENSEMBL proteins:

ENSP00000086933

Human Recombinant Protein Products for GSC2:

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	Cloud-Clone Corp. Proteins for GSC2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

GSC2 for ontologies About GeneDecksing

GSC2 Antibody Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

PRD: Homeoboxes / PRD class

3 InterPro protein domains:

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry O15499

ProtoNet protein and cluster: O15499

UniProtKB/Swiss-Prot: GSC2_HUMAN, O15499

Similarity: Belongs to the paired homeobox family. Bicoid subfamily

Similarity: Contains 1 homeobox DNA-binding domain

GSC2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GSC2_HUMAN, O15499

Function: May have a role in development. May regulate its own transcription. May bind the bicoid consensus

sequence TAATCC

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	9441739
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	9700206
GO:0005515	protein binding	--	--
GO:0043565	sequence-specific DNA binding	IEA	--

GSC2 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Gsc2):

embryogenesis

normal

GSC2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for GSC2: Gsc2^tm1Bhr Gsc2^tm1Ais

inGenious Targeting Laboratory - Custom generated mouse model solutions for GSC2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSC2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSC2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSC2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSC2
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GSC2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for GSC2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for GSC2 (O15499³ ENSP00000086933⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RNF4	P78317³, ENSP00000315212⁴	I2D: score=1 STRING: ENSP00000315212

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA	9700206
GO:0009653	anatomical structure morphogenesis	TAS	9150167

GSC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GSC2

Search CenterWatch for drugs/clinical trials and news about GSC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSC2 gene:

NM_005315.1

Unigene Cluster for GSC2:

Goosecoid homeobox 2

Hs.534318

Unigene Representative Sequence: NM_005315

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000086933(uc011ags.2)

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		GenScript: all cDNA clones in your preferred vector: GSC2 (NM_005315)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSC2

1 DOTS entry:

DT.92014810

1 AceView cDNA sequence:

NM_005315

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSC2 expression in normal human tissues (normalized intensities) GSC2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

GSC2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/2 selected tissues (see all 2) fully expand


Brain (Nervous System) fully expand to see all 5 entries
Pons
Midbrain

Neural Tube (Nervous System)
Mesencephalon

See GSC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSC2

SOURCE GeneReport for Unigene cluster: Hs.534318

UniProtKB/Swiss-Prot: GSC2_HUMAN, O15499

Tissue specificity: Detected in adult testis and pituitary, and in 9-10 week fetal tissue (thorax). Probably

expressed in other tissues at low levels

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GSC2 gene from 6/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gsc2^{1 , 5}	goosecoid homebox 2^{1, 5}	79.06(n)¹ 77.89(a)¹		16 (11.10 cM)⁵ 195333¹ NM_029469.1¹ NP_083745.1¹ 17913114⁵
chicken (Gallus gallus)	Aves	GSC2⁶	Uncharacterized protein	46(a)	1 ↔ 1	15(7863779-7865588)
lizard (Anolis carolinensis)	Reptilia	GSC2⁶	Uncharacterized protein	48(a)	1 ↔ 1	GL343282.1(760171-765966)
zebrafish (Danio rerio)	Actinopterygii	GSC2⁶ dharma⁶	dharma	35(a) 19(a)	1 ↔ 1 possible ortholog	5(1385395-1389016) 15(28360391-28361587)
fruit fly (Drosophila melanogaster)	Insecta	Gsc⁶	Goosecoid	13(a)	1 → many	2L(583540-594810)
worm (Caenorhabditis elegans)	Secernentea	ceh-45⁶	Protein CEH-45	23(a)	1 → many	I(1128324-1131737)

ENSEMBL Gene Tree for GSC2 (if available)
TreeFam Gene Tree for GSC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GSC2 gene

GSC² PITX1² OTX2² UNCX² VSX1² HESX1² RHOXF2² PITX2²

VSX2² RHOXF1² PITX3² DMBX1² ESX1² OTX1² CRX² RHOXF2B²

3 SIMAP similar genes for GSC2 using alignment to 1 protein entry: GSC2_HUMAN:

RAX2 MIXL1 PITX1

GSC2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190395947^1,2	C	--	19136007(+)	`GATACC/TAAGAC`	1	--	ds500¹		0	--	--	--	--
rs183516375^1,2		--	19136059(+)	`AGACAA/CGAACC`	1	--	ds500¹		0	--	--	--	--
rs188092208^1,2		--	19136133(+)	`AGAGGA/GTGGCC`	1	--	ds500¹		0	--	--	--	--
rs148679187^1,2	C	--	19136165(+)	`AGACGC/TTCCAC`	1	--	ds500¹		0	--	--	--	--
rs2071339^1,2	C,F,A,H	--	19136203(-)	`ACCACC/TCCGTA`	1	--	ds500¹		12		EA NS NA WA CSA	1587
rs116494273^1,2	F	--	19136235(+)	`GTGTCT/CCTCGG`	1	--	ds500¹		1		WA	118
rs115142721^1,2	C	--	19136240(+)	`TCTCGG/TGGGGT`	1	--	ds500¹		0	--	--	--	--
rs115999679^1,2	F	--	19136294(+)	`GGACTC/GGCCAC`	1	--	ds500¹		1		WA	118
rs192709390^1,2		--	19136327(+)	`GCACCG/TGGGGC`	1	--	ds500¹		0	--	--	--	--
rs182828430^1,2		--	19136330(+)	`CCGGGC/GGCCCG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GSC2 (19136089 - 19137796 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for GSC2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv435744	CNV	Deletion	17901297
nsv834122	CNV	Loss	17160897
nsv914263	CNV	Gain	21882294
nsv914268	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing GSC2

DNA2.0 Custom Variant and Variant Library Synthesis for GSC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 601845 OMIM disorders: --

5 diseases for GSC2: About MalaCards

velocardiofacial syndrome digeorge syndrome learning disability pharyngitis

atherosclerosis

2 diseases from the University of Copenhagen DISEASES database for GSC2:

Velocardiofacial syndrome DiGeorge syndrome

GSC2 for disorders About GeneDecksing

Genetic Association Database (GAD): GSC2

Export disorders for GSC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GSC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with GSC2)

Utopia: connect your pdf to the dynamic
world of online information

The DiGeorge syndrome minimal critical region contains a goosecoid- like (GSCL) homeobox gene that is expressed early in human development. (PubMed id 9150167)^{1, 2, 3, 9} Gottlieb S.... Budarf M.L. (1997)
Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11. (PubMed id 9441739)^{1, 2} Funke B.... Morrow B.E. (1997)
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)⁴ Kettunen J....Ripatti S. (2012)
Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)¹ Inouye M....de Bakker P.I. (2012)
Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region. (PubMed id 10822263)¹ Galili N....Buck C.A. (2000)
Goosecoid-like, a gene deleted in DiGeorge and velocardiofacial syndromes, recognizes DNA with a bicoid-like specificity and is expressed in the developing mouse brain. (PubMed id 9700206)¹ Gottlieb S....Budarf M.L. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2928	HGNC: 4613	AceView: GSCL	Ensembl:ENSG00000063515	euGenes: HUgn2928
ECgene: GSC2	H-InvDB: GSC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GSC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GSC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for GSC2 gene:
Search GeneIP for patents involving GSC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

	Browse Small Molecules at EMD Millipore
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	EMD Millipore Mono- and Polyclonal Antibodies for the study of GSC2
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	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for GSC2
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for GSC2
	OriGene qSTAR qPCR primer pairs in human, mouse for GSC2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for GSC2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for GSC2		OriGene Custom Protein Services for GSC2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GSC2
	QIAGEN SeqTarget long-range PCR primers for resequencing GSC2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSC2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSC2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSC2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSC2

	GenScript Custom Purified and Recombinant Proteins Services for GSC2		GenScript cDNA clones with any tag delivered in your preferred vector for GSC2
	GenScript Custom Assay Services for GSC2		GenScript Custom Superior Antibodies Services for GSC2
	GenScript Custom overexpressing Cell Line Services for GSC2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in GSC2 promoter
	Search Chromatin IP Primers for GSC2
	RT² qPCR Primer Assay in human, mouse, rat GSC2
	Search GNC Networks for GSC2
	SABiosciences Custom PCR Arrays for GSC2

Search Tocris compounds for GSC2

	Browse Sino Biological Proteins and Antibodies
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	Protein Production Services
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Antibodies for GSC2
	See all of Abcam's Antibodies, Kits and Proteins for GSC2
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Browse ProSpec Recombinant Proteins

	Proteins for GSC2
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Search LifeMap BioReagents cell lines for GSC2

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSC2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for GSC2
	SwitchGear Promoter luciferase reporter plasmids for GSC2

Search ThermoFisher Antibodies for GSC2

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GSC2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for GSC2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSC2

Customized:

	lentivirus for stable overexpression of GSC2
	lentivirus expression plasmids for stable overexpression of GSC2
	adenovirus for overexpression of GSC2

LSBio Antibodies in human, mouse, rat for GSC2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes GSC2 gene at Home site.

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GSC2 Gene

Goosecoid Homeobox 2

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Export list of displayed genes

GSC2 Gene

Goosecoid Homeobox 2

Aliasesfor GSC2 gene

Summariesfor GSC2 gene

Genomic Viewsfor GSC2 gene

Proteinsfor GSC2 gene

Protein Domains /Familiesfor GSC2 gene

Functionfor GSC2 gene

Pathways & Interactionsfor GSC2 gene

Drugs & Compoundsfor GSC2 gene

Transcriptsfor GSC2 gene

Expression for GSC2 gene

Orthologsfor GSC2 gene

Paralogsfor GSC2 gene

Genomic Variantsfor GSC2 gene

Disorders / Diseasesfor GSC2 gene

Publicationsfor GSC2 gene

External Searches for GSC2 gene

Genome Databases showing GSC2 gene

Other Databases showing GSC2 gene

Specialized Databases showing GSC2 gene

Intellectual Propertyfor GSC2 gene

Productsfor GSC2 gene

View Random Gene

Aliases
for GSC2 gene

Summaries
for GSC2 gene

Genomic Views
for GSC2 gene

Proteins
for GSC2 gene

Protein Domains /
Families
for GSC2 gene

Function
for GSC2 gene

Pathways & Interactions
for GSC2 gene

Drugs & Compounds
for GSC2 gene

Transcripts
for GSC2 gene

Expression
for GSC2 gene

Orthologs
for GSC2 gene

Paralogs
for GSC2 gene

Genomic Variants
for GSC2 gene

Disorders / Diseases
for GSC2 gene

Publications
for GSC2 gene

Intellectual Property
for GSC2 gene

Products
for GSC2 gene