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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GSC Gene

protein-coding GIFtS: 56
GCID: GC14M095234

Goosecoid Homeobox

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Goosecoid Homeobox¹ ²
Homeobox Protein Goosecoid²

External Ids:	HGNC: 4612¹	Entrez Gene: 145258²	Ensembl: ENSG00000133937⁷	OMIM: 138890⁵	UniProtKB: P56915³

Export aliases for GSC gene to outside databases

Previous GC identifers: GC14U990025 GC14M089051 GC14M093224 GC14M094304 GC14M075414

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GSC Gene:

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded

protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in

craniofacial and rib cage development during embryogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for GSC Gene:

GSC (goosecoid homeobox) is a protein-coding gene. Diseases associated with GSC include miller fisher syndrome, and auditory neuropathy. GO annotations related to this gene include RNA polymerase II transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PITX1.

UniProtKB/Swiss-Prot: GSC_HUMAN, P56915

Function: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or

lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural

components of the middle ear; required for the development of the entire tympanic ring (By similarity)

Gene Wiki entry for GSC Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.2 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GSC gene promoter:
COUP-TF1 COUP-TF COUP MyoD HNF-4alpha2 Nkx2-5 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSC promoter sequence

Search SABiosciences Chromatin IP Primers for GSC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32.13

GSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSC gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M095234: view genomic region (about GC identifiers)

Start:	95,234,553 bp from pter	End:	95,236,562 bp from pter
Size:	2,010 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GSC_HUMAN, P56915 (See protein sequence)

Recommended Name: Homeobox protein goosecoid

Size: 257 amino acids; 28150 Da

Subcellular location: Nucleus

1 PDB 3D structure from and Proteopedia for GSC:

2DMU (3D)

Secondary accessions: Q86YR1

Explore the universe of human proteins at neXtProt for GSC: NX_P56915

Explore proteomics data for GSC at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P56915

GSC Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_776248.1

ENSEMBL proteins:

ENSP00000238558

Human Recombinant Protein Products for GSC:

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	Novus Biologicals GSC Proteins Novus Biologicals GSC Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
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	Cloud-Clone Corp. Proteins for GSC

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005667	transcription factor complex	IEA	--

GSC for ontologies About GeneDecksing

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Assay Products for GSC:

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	Cloud-Clone Corp. ELISAs for GSC Cloud-Clone Corp. CLIAs for GSC

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

PRD: Homeoboxes / PRD class

3 InterPro protein domains:

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P56915

ProtoNet protein and cluster: P56915

UniProtKB/Swiss-Prot: GSC_HUMAN, P56915

Similarity: Belongs to the paired homeobox family. Bicoid subfamily

Similarity: Contains 1 homeobox DNA-binding domain

GSC for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: GSC_HUMAN, P56915

Function: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or

lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural

components of the middle ear; required for the development of the entire tympanic ring (By similarity)

Genatlas biochemistry entry for GSC:

Xenopus goosecoid homologous,homeo domain encoding gene,expressed during,and involved in,gastrulation process

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001085	RNA polymerase II transcription factor binding	ISS	--
GO:0001103	RNA polymerase II repressing transcription factor binding	ISS	--
GO:0003677	DNA binding	NAS	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	--	--

GSC for ontologies About GeneDecksing

Phenotypes:
15/17 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gsc) (see all 17):

behavior/neurological	cardiovascular system	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	integument	limbs/digits/tail
mortality/aging	muscle	nervous system	respiratory system	skeleton

GSC for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for GSC: Gsc^tm1Pgr Gsc^tm1Bhr

inGenious Targeting Laboratory - Custom generated mouse model solutions for GSC

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GSC

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GSC

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GSC

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSC
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate GSC:
		hsa-miR-885-3p hsa-miR-562 hsa-miR-19b hsa-miR-19a hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: GSC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GSC
		Search LifeMap BioReagents cell lines for GSC

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for GSC About

See pathways by source

SuperPath

Contained pathways About

Regulation of nuclear SMAD2/3 signaling

Regulation of nuclear SMAD2/3 signaling

Regulation of retinoblastoma protein

Regulation of retinoblastoma protein

2 BioSystems Pathways for GSC

	Regulation of retinoblastoma protein
	Regulation of nuclear SMAD2/3 signaling

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GSC

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/20 Interacting proteins for GSC (P56915³ ENSP00000238558⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD2	Q15796³, ENSP00000262160⁴	I2D: score=3 STRING: ENSP00000262160
SMAD3	P84022³, ENSP00000332973⁴	I2D: score=3 STRING: ENSP00000332973
FOXA2	Q9Y261³, ENSP00000315955⁴	I2D: score=2 STRING: ENSP00000315955
SMAD1	Q15797³, ENSP00000305769⁴	I2D: score=3 STRING: ENSP00000305769
HDAC11	Q96DB2³, ENSP00000295757⁴	I2D: score=1 STRING: ENSP00000295757

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007369	gastrulation	NAS	7916327
GO:0009653	anatomical structure morphogenesis	--	--
GO:0021904	dorsal/ventral neural tube patterning	IEA	--

GSC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GSC

Search CenterWatch for drugs/clinical trials and news about GSC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GSC gene:

NM_173849.2

Unigene Cluster for GSC:

Goosecoid homeobox

Hs.440438 [show with all ESTs]

Unigene Representative Sequence: BG112580

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000238558(uc001ydu.3)

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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate GSC:
		hsa-miR-885-3p hsa-miR-562 hsa-miR-19b hsa-miR-19a hsa-miR-3714
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSC

Additional mRNA sequence:

AY177407.1 BC063580.1

2 DOTS entries:

DT.100018623 DT.100660023

11 AceView cDNA sequences:

CA414748 BC063580 NM_173849 AY177407 BQ446670 AI758825 BQ772276 BQ771765

BX091000 AW138807 CB219115

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GSC expression in normal human tissues (normalized intensities) GSC embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AACGTGGGCA

About this image

GSC expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/18 selected tissues (see all 18) fully expand


Primitive Streak (Early Embryonic Tissues) fully expand to see all 10 entries
Anterior Primitive Streak Cells Anterior Primitive Streak
Primitive streak-like cells ( Generation of endoderm cells and pancreatic progenitor...

Epiblast (Early Embryonic Tissues) fully expand to see all 6 entries
Early-Gastrula Organizer Epiblast
Epiblast Stem Cell line 5

Bone (Muscoskeletal System) fully expand to see all 4 entries
Mesenchymal Condensate Cells Zeugopod
Mandibular Process
Chondrocyte-like cells ( Direct differentiation of human embryonic stem cells into...
sensory organ/ear/inner ear

Mesoderm (Gastrulation Derivatives) fully expand to see all 4 entries
Mesoderm Cells Mesoderm
Mesoderm
Mesoderm-like cells ( Direct differentiation of human embryonic stem cells into chondrocytes...

Limb (Muscoskeletal System) fully expand to see all 4 entries
Mesenchymal Condensate Cells Zeugopod
Autopod
limb/hindlimb

See GSC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GSC

SOURCE GeneReport for Unigene cluster: Hs.440438

SABiosciences Expression via Pathway-Focused PCR Arrays including GSC:

TGFB/BMP Signaling Pathway in human mouse rat

Cancer PathwayFinder in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GSC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GSC gene from 7/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gsc^{1 , 5}	goosecoid homeobox^{1, 5}	92.71(n)¹ 97.27(a)¹		12 (54.32 cM)⁵ 14836¹ NM_010351.1¹ NP_034481.1¹ 104471209⁵
chicken (Gallus gallus)	Aves	GSC¹	goosecoid homeobox	82.04(n) 89.8(a)		396273 NM_205331.1 NP_990662.1
lizard (Anolis carolinensis)	Reptilia	GSC⁶	Uncharacterized protein	82(a)	1 ↔ 1	1(6723154-6736769)
African clawed frog (Xenopus laevis)	Amphibia	LOC397748²	homeobox protein	75.48(n)		M81481.1
zebrafish (Danio rerio)	Actinopterygii	gsc²	goosecoid	75.22(n)		30212 L03395.1
fruit fly (Drosophila melanogaster)	Insecta	Gsc⁶	Goosecoid	17(a)	1 → many	2L(583540-594810)
worm (Caenorhabditis elegans)	Secernentea	ceh-45⁶	Protein CEH-45	23(a)	1 → many	I(1128324-1131737)

ENSEMBL Gene Tree for GSC (if available)
TreeFam Gene Tree for GSC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GSC gene

PITX1² OTX2² UNCX² VSX1² HESX1² RHOXF2² PITX2² VSX2²

RHOXF1² PITX3² DMBX1² ESX1² GSC2² OTX1² CRX² RHOXF2B²

2 SIMAP similar genes for GSC using alignment to 1 protein entry: GSC_HUMAN:

HESX1 POU6F1

GSC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4511463^1,2	C,F,A,H	--	95234173(+)	`AGCTTG/AGAGCA`	1	--	ds500¹		28		NA NS EA WA CSA	2907
rs190854357^1,2	C	--	95234345(+)	`AAACCC/TTCCTA`	1	--	ds500¹		0	--	--	--	--
rs182689395^1,2		--	95234374(+)	`AAACCA/GGGACA`	1	--	ds500¹		0	--	--	--	--
rs3850401^1,2	C,F,A	--	95234442(+)	`GATCAG/TAGCTG`	1	--	ds500¹		14		NA WA CSA EA	516
rs3850402^1,2	C,F,A	--	95234452(+)	`GCTCAA/GTTTTT`	1	--	ds500¹		12		NA WA CSA EA	512
rs138867999^1,2		--	95234753(+)	`CGTGTG/TCAAGA`	1	--	ut3¹		0	--	--	--	--
rs199891655^1,2		--	95234861(+)	`CCTTCC/TTCTTC`	2	E	syn¹		0	--	--	--	--
rs141452513^1,2		--	95234970(+)	`GCGGC-/GGGTTC`	2	R PP	fra¹		0	--	--	--	--
rs202126439^1,2	C	--	95235015(+)	`CAGTTC/TAGATC`	1	--	int¹		0	--	--	--	--
rs201517530^1,2		--	95235026(+)	`AAAGGA/CGCGCT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GSC (95234553 - 95236562 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for GSC: About this table

Variant ID	Type	Subtype	PubMed ID
nsv470662	CNV	Gain	18288195
nsv902208	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): GSC

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing GSC

DNA2.0 Custom Variant and Variant Library Synthesis for GSC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 138890 OMIM disorders: --

11 diseases for GSC: About MalaCards

miller fisher syndrome auditory neuropathy microtia cornelia de lange syndrome

velocardiofacial syndrome guillain-barre syndrome digeorge syndrome malignant glioma

neuropathy type 1 diabetes retinoblastoma

GSC for disorders About GeneDecksing

Genetic Association Database (GAD): GSC
Human Genome Epidemiology (HuGE) Navigator: GSC (4 documents)

Export disorders for GSC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for GSC gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with GSC)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1. (PubMed id 7916327)^{1, 2, 3, 9} Blum M.... Sparkes R.S. (1994)
Environmental and genetic factors associated with con genital microtia: a case-control study in Jiangsu, China, 2004 to 2007. (PubMed id 19935299)^{1, 4, 9} Zhang Q.G....Shen H. (2009)
A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)^{1, 4} Paterson A.D....Bull S.B. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. (PubMed id 12642491)^{1, 9} Foucher I....Trembleau A. (2003)
EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differe ntiation by directly repressing GOOSECOID expression. (PubMed id 22178155)¹ Kalisz M....Serup P. (2012)
Evaluation of four novel genetic variants affecting h emoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 st udy). (PubMed id 21294870)¹ Hertel J.K....RA (2011)
Pedigree and genetic study of a bilateral congenital microtia family. (PubMed id 20195123)¹ Zhang Q....Yin W. (2010)
A child with deletion (14)(q24.3q32.13) and auditory neuropathy. (PubMed id 18074379)¹ Schlade-Bartusiak K....Cox D.W. (2008)
The Spemann organizer gene, Goosecoid, promotes tumor metastasis. (PubMed id 17142318)¹ Hartwell K.A....Weinberg R.A. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 145258	HGNC: 4612	AceView: GSC	Ensembl:ENSG00000133937	euGenes: HUgn145258
ECgene: GSC	H-InvDB: GSC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GSC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GSC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GSC gene:
Search GeneIP for patents involving GSC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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