GSC Gene

Aliases
for GSC gene

Previous GC identifers: GC14U990025 GC14M089051 GC14M093224 GC14M094304 GC14M075414

Summaries
for GSC gene

Genomic Views
for GSC gene

RefSeq DNA sequence:

NC_000014.8  NC_018925.1  NT_026437.12  

SwitchGear Promoter luciferase reporter plasmid: GSC promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSC

GSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M095234:  view genomic region     (about GC identifiers)

Proteins
for GSC gene

1 PDB 3D structure from and Proteopedia for GSC:

2DMU (3D)    

Explore the universe of human proteins at neXtProt for GSC: NX_P56915

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: GSC OriGene Custom Protein Services for GSC
	GenScript Custom Purified and Recombinant Proteins Services for GSC
	Novus Biologicals GSC Proteins Novus Biologicals GSC Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for GSC

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of GSC
	R&D Systems Antibodies for GSC (Goosecoid)
	OriGene Antibodies (see all 3): GSC OriGene Custom Antibody Services for GSC
	GenScript Custom Superior Antibodies Services for GSC
	Novus Biologicals GSC Antibodies
	Abcam antibodies for GSC
	Uscn Antibodies for GSC
	Search ThermoFisher Antibodies for GSC

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for GSC (Goosecoid)
	GenScript Custom Assay Services for GSC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GSC

Protein Domains /
Families
for GSC gene

ProtoNet protein and cluster: P56915

Function
for GSC gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSC
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate GSC:
		hsa-miR-885-3p hsa-miR-562 hsa-miR-19b hsa-miR-19a hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: GSC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSC (see all 4) OriGene shRNA RFP: GSC OriGene siRNA: GSC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSC

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for GSC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSC (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSC OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GSC (NM_005315)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GSC
		Search LifeMap BioReagents cell lines for GSC

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GSC

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

15/17 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gsc)

Pathways & Interactions
for GSC gene

	Super-pathway	contained gene-specific pathways
1	Regulation of nuclear SMAD2/3 signaling	Regulation of nuclear SMAD2/3 signaling 1.00
2	Regulation of retinoblastoma protein	Regulation of retinoblastoma protein 1.00

2 BioSystems Pathways for GSC

	Regulation of nuclear SMAD2/3 signaling
	Regulation of retinoblastoma protein

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

Drugs & Compounds
for GSC gene

Transcripts
for GSC gene

Expression
for GSC gene

GSC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACGTGGGCA

10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeVascular AdiposeStromal Vascular Preadipocyte Progenitor Cells			Adipose
	Primitive StreakAnterior Primitive StreakAnterior Primitive Streak Cells			Early Embryo
	EpiblastEpiblastEarly-Gastrula Organizer			Early Embryo
	Neural TubeMesencephalic Floor PlateEarly Floor Plate Cells			Neural Ectoderm
	Neural TubeMesencephalic Floor PlateLate Floor Plate Cells			Neural Ectoderm
	Primitive StreakPrechordal PlatePrechordal Plate Cells			Early Embryo
	Primitive StreakPrimitive NodePrimitive Node Cells			Early Embryo
	Primitive StreakPrimitive StreakMesendoderm Cells			Early Embryo
	LimbZeugopodMesenchymal Condensate Cells			Bone, Cartilage
	Skeletal MuscleHyoid Arch MusclesMononuclear Myocytes			Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14)
	Name			Category
	Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Primitive Streak Mesendoderm cells (Direct differentiati...)
	Primitive streak-like cells (Generation of primit...)
	Definitive endoderm-like cells (Generation and expan...)
	Definitive endoderm-like cells (Generation of mesend...)
	Mesendoderm-like cells (Generation of mesend...)
	Definitive endoderm-like cells (A scalable, suspensi...)
	Mesendoderm-like cells (A scalable, suspensi...)
	Primitive streak-like cells (Generation of endode...)
	Mesendoderm-like cells (Generation of interm...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GSC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GSC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSC

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GSC

Orthologs
for GSC gene

Paralogs
for GSC gene

Paralogs for GSC gene

OTX2²  HESX1²  PROP1²  ARGFX²  DMBX1²  GSC2²  SEBOX²  OTX1²  

CRX²  MIXL1²  

3 SIMAP similar genes for GSC using alignment to 1 protein entry:     GSC_HUMAN:

HESX1    POU6F1    GSC2

GSC for paralogs           About GeneDecksing

Genomic Variants
for GSC gene

10/53 NCBI SNPs in GSC are shown (see all 53)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs45114631,2	C,F,A,H,	--	95234173(+)	AGCTTG/AGAGCA	1	--	ds5001		28		NA NS EA WA CSA	2907
rs1908543571,2		--	95234345(+)	AAACCC/TTCCTA	1	--	ds5001		0	--	--	--	--
rs1826893951,2		--	95234374(+)	AAACCA/GGGACA	1	--	ds5001		0	--	--	--	--
rs38504011,2	C,F,A,	--	95234442(+)	GATCAG/TAGCTG	1	--	ds5001		14		NA WA CSA EA	516
rs38504021,2	C,F,A,	--	95234452(+)	GCTCAA/GTTTTT	1	--	ds5001		12		NA WA CSA EA	512
rs1388679991,2		--	95234753(+)	CGTGTG/TCAAGA	1	--	ut31		0	--	--	--	--
rs1998916551,2		--	95234861(+)	CCTTCC/TTCTTC	2	E	syn1		0	--	--	--	--
rs1414525131,2		--	95234968(+)	GCGGC-/GGGTTC	2	RR RPR	fra1		0	--	--	--	--
rs2021264391,2		--	95235015(+)	CAGTTC/TAGATC	1	--	int1		0	--	--	--	--
rs2015175301,2		--	95235026(+)	AAAGGA/CGCGCT	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for GSC (95234553 - 95236562 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for GSC: --
Human Gene Mutation Database (HGMD): GSC

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSC

DNA2.0 Custom Variant and Variant Library Synthesis for GSC

Disorders / Diseases
for GSC gene

Publications
for GSC gene

PubMed articles for GSC gene integrated from 9 sources (see top 10): (articles sorted by number of sources associating them with GSC)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1. (PubMed id 7916327)^{1, 2, 3, 9} Blum M.... Sparkes R.S. (1994)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Environmental and genetic factors associated with con genital microtia: a case-control study in Jiangsu, China, 2004 to 2007. (PubMed id 19935299)^{1, 9} Zhang Q.G....Shen H. (2009)
4. Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. (PubMed id 12642491)^{1, 9} Foucher I....Trembleau A. (2003)
5. EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differe ntiation by directly repressing GOOSECOID expression. (PubMed id 22178155)¹ Kalisz M....Serup P. (2012)
6. Evaluation of four novel genetic variants affecting h emoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 st udy). (PubMed id 21294870)¹ Hertel J.K....RA (2011)
7. Pedigree and genetic study of a bilateral congenital microtia family. (PubMed id 20195123)¹ Zhang Q....Yin W. (2010)
8. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)¹ Paterson A.D....Bull S.B. (2010)
9. A child with deletion (14)(q24.3q32.13) and auditory neuropathy. (PubMed id 18074379)¹ Schlade-Bartusiak K....Cox D.W. (2008)
10. The Spemann organizer gene, Goosecoid, promotes tumor metastasis. (PubMed id 17142318)¹ Hartwell K.A....Weinberg R.A. (2006)
11. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)¹ Barrios-Rodiles M....Wrana J.L. (2005)
12. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. (PubMed id 15014966)¹ Namciu S.J....Fournier R.E. (2004)
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
14. Negative autoregulation of the organizer-specific homeobox gene goosecoid. (PubMed id 9417125)¹ Danilov V....Steinbeisser H. (1998)
15. Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizer. (PubMed id 11532920)⁹ Yao J. and Kessler D.S. (2001)
16. Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. (PubMed id 10926781)⁹ Mochizuki T....Taira M. (2000)
17. The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. (PubMed id 7489713)⁹ Steinbeisser H....De Robertis E.M. (1995)
18. The homeobox gene goosecoid controls cell migration i n Xenopus embryos. (PubMed id 8095000)⁹ Niehrs C....De Robertis E.M. (1993)
19. Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. (PubMed id 18922797)⁹ Cao Y....Knochel W. (2008)
20. Antimorphic goosecoids. (PubMed id 9502717)⁹ Ferreiro B....Niehrs C. (1998)
21. Xenopus goosecoid: a gene expressed in the prechordal plate that has dorsalizing activity. (PubMed id 7521271)⁹ Steinbeisser H. and De Robertis E.M. (1993)
22. Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes. (PubMed id 10480362)⁹ Smith M....Strachan T. (1999)
23. Interaction of goosecoid and brachyury in Xenopus mesoderm patterning. (PubMed id 9256355)⁹ Artinger M....Cho K.W. (1997)
24. Drosophila goosecoid participates in neural developme nt but not in body axis formation. (PubMed id 8670808)⁹ Hahn M. and JAockle H. (1996)
25. The homeobox gene goosecoid and the origin of organiz er cells in the early chick blastoderm. (PubMed id 7916659)⁹ IzpisA_a-Belmonte J.C....Stern C.D. (1993)
26. XIPOU 2 is a potential regulator of Spemann's Organizer. (PubMed id 9102305)⁹ Witta S.E. and Sato S.M. (1997)
27. A functional homologue of goosecoid in Drosophila. (PubMed id 8625850)⁹ Goriely A....Desplan C. (1996)
28. Activin A induces craniofacial cartilage from undifferentiated Xenopus ectoderm in vitro. (PubMed id 12424341)⁹ Furue M....Asashima M. (2002)
29. Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation. (PubMed id 12498689)⁹ Branford W.W. and Yost H.J. (2002)
30. Formation of the middle ear: recent progress on the developmental and molecular mechanisms. (PubMed id 11237469)⁹ Mallo M. (2001)
31. The Xvex-1 antimorph reveals the temporal competence for organizer formation and an early role for ventral homeobox genes. (PubMed id 10585564)⁹ Shapira E....Fainsod A. (2000)
32. Development and control of tissue separation at gastrulation in Xenopus. (PubMed id 10926778)⁹ Wacker S....Winklbauer R. (2000)
33. Site-specific heterodimerization by paired class homeodomain proteins mediates selective transcriptional responses. (PubMed id 10542273)⁹ Tucker S.C. and Wisdom R. (1999)
34. Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11. (PubMed id 9441739)⁹ Funke B.... Morrow B.E. (1997)
35. The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm. (PubMed id 8898218)⁹ Onichtchouk D....Niehrs C. (1996)
36. Effect of activin and lithium on isolated Xenopus animal blastomeres and response alteration at the midblastula transition. (PubMed id 7600976)⁹ Kinoshita K. and Asashima M. (1995)
37. The surprising complexity of the transcriptional regulation of the spdri gene reveals the existence of new linkages inside sea urchin's PMC and Oral Ectoderm Gene Regulatory Networks. (PubMed id 18718463)⁹ Mahmud A.A. and Amore G. (2008)
38. Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. (PubMed id 16900388)⁹ Long J.M....Wynshaw-Boris A. (2006)
39. Role of Goosecoid, Xnot and Wnt antagonists in the maintenance of the notochord genetic programme in Xenopus gastrulae. (PubMed id 11585804)⁹ Yasuo H. and Lemaire P. (2001)
40. The role of maternal axin in patterning the Xenopus embryo. (PubMed id 11518515)⁹ Kofron M....Heasman J. (2001)
41. Expression of the organizer specific homeobox gene goosecoid (gsc) in porcine embryos. (PubMed id 10602267)⁹ Meijer H.A....Boerjan M.L. (2000)
42. Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression. (PubMed id 9539748)⁹ Crease D.J....Gurdon J.B. (1998)
43. The Xcad-2 gene can provide a ventral signal independent of BMP-4. (PubMed id 9651504)⁹ Pillemer G....Fainsod A. (1998)
44. Goosecoid-like (Gscl), a candidate gene for velocardiofacial syndrome, is not essential for normal mouse development. (PubMed id 9811927)⁹ Saint-Jore B....Skoultchi A.I. (1998)

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