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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GSC Gene

protein-coding   GIFtS: 55
GCID: GC14M095234

goosecoid homeobox
 Explore 7 diseases affiliated with
GSC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GSC    

Aliases
for GSC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Goosecoid Homeobox1 2
Homeobox Protein Goosecoid2

External Ids:    HGNC: 46121   Entrez Gene: 1452582   Ensembl: ENSG000001339377   OMIM: 1388905   UniProtKB: P569153   

Export aliases for GSC gene to outside databases

Previous GC identifers: GC14U990025 GC14M089051 GC14M093224 GC14M094304 GC14M075414


Summaries
for GSC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GSC:
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein
acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and
rib cage development during embryogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GSC_HUMAN, P56915
Function: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage
compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the
middle ear; required for the development of the entire tympanic ring (By similarity)

Gene Wiki entry for GSC


Genomic Views
for GSC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GSC gene promoter:
         COUP-TF1   COUP-TF   COUP   MyoD   HNF-4alpha2   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GSC promoter sequence
   Search SABiosciences Chromatin IP Primers for GSC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GSC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.13

GSC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GSC gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M095234:  view genomic region     (about GC identifiers)

Start:
 95,234,553 bp from pter      End:
 95,236,562 bp from pter
Size:
 2,010 bases      Orientation:
 minus strand

Proteins
for GSC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GSC_HUMAN, P56915 (See protein sequence)
Recommended Name: Homeobox protein goosecoid  
Size: 257 amino acids; 28150 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for GSC:
2DMU (3D)    
Secondary accessions: Q86YR1

Explore the universe of human proteins at neXtProt for GSC: NX_P56915

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56915

    • GSC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_776248.1  
    ENSEMBL proteins: 
     ENSP00000238558  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: GSC
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    Novus Biologicals GSC Proteins
    Novus Biologicals GSC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GSC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005667transcription factor complex IEA--


    GSC for ontologies           About GeneDecksing



    GSC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GSC
    R&D Systems Antibodies for GSC (Goosecoid)
    OriGene Antibodies (see all 3): GSC
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    GenScript Custom Superior Antibodies Services for GSC
    Novus Biologicals GSC Antibodies
    Abcam antibodies for GSC 
    Uscn Antibodies for GSC
    Search ThermoFisher Antibodies for GSC

    Assay Products for GSC: 
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    Uscn ELISAs and CLIAs for GSC

    Protein Domains /
    Families
    for GSC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GSC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P56915

    ProtoNet protein and cluster: P56915

    UniProtKB/Swiss-Prot: GSC_HUMAN, P56915
    Similarity: Belongs to the paired homeobox family. Bicoid subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for GSC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GSC_HUMAN, P56915
    Function: Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage
    compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the
    middle ear; required for the development of the entire tympanic ring (By similarity)

         Genatlas biochemistry entry for GSC:
    Xenopus goosecoid homologous,homeo domain encoding gene,expressed during,and involved in,gastrulation process

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSC
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate GSC:
    hsa-miR-885-3p hsa-miR-562 hsa-miR-19b hsa-miR-19a hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmid: GSC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSC (see all 4)
    OriGene shRNA RFP: GSC
    OriGene siRNA: GSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GSC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GSC (see all 2)
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    GenScript: all cDNA clones in your preferred vector: GSC (NM_005315)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSC 

    Cell Line
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    Search LifeMap BioReagents cell lines for GSC

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GSC

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding ISS--
    GO:0001103RNA polymerase II repressing transcription factor binding ISS--
    GO:0003677DNA binding NAS--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----


    GSC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for GSC: Gsctm1Pgr Gsctm1Bhr
         15/17 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Gsc) (see all 17):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  integument  limbs/digits/tail 
     mortality/aging  muscle  nervous system  respiratory system  skeleton 

    GSC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GSC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of nuclear SMAD2/3 signaling
    		Regulation of nuclear SMAD2/3 signaling1.00
    2Regulation of retinoblastoma protein
    		Regulation of retinoblastoma protein1.00


    2 BioSystems Pathways for GSC 
        Regulation of nuclear SMAD2/3 signaling
    Regulation of retinoblastoma protein


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GSC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/20 Interacting proteins for GSC (P569153 ENSP000002385584) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=3 STRING: ENSP00000332973
    FOXA2Q9Y2613, ENSP000003159554I2D: score=2 STRING: ENSP00000315955
    SMAD1Q157973, ENSP000003057694I2D: score=3 STRING: ENSP00000305769
    HDAC11Q96DB23, ENSP000002957574I2D: score=1 STRING: ENSP00000295757
    About this table

    Gene Ontology (GO): 11 biological process terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007369gastrulation NAS7916327
    GO:0009653anatomical structure morphogenesis ----
    GO:0021904dorsal/ventral neural tube patterning IEA--
    GO:0023019signal transduction involved in regulation of gene expression IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway IEA--
    GO:0030900forebrain development IEA--
    GO:0042474middle ear morphogenesis ISS--
    GO:0043583ear development ----
    GO:0048644muscle organ morphogenesis IEA--
    GO:0048704embryonic skeletal system morphogenesis IEA--


    GSC for ontologies           About GeneDecksing



    Drugs & Compounds
    for GSC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GSC
    Search CenterWatch for drugs/clinical trials and news about GSC 

    Transcripts
    for GSC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GSC gene: 
    NM_173849.2  

    Unigene Cluster for GSC:

    Goosecoid homeobox
    Hs.440438  [show with all ESTs]
    Unigene Representative Sequence: BG112580
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000238558(uc001ydu.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GSC
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate GSC:
    hsa-miR-885-3p hsa-miR-562 hsa-miR-19b hsa-miR-19a hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmid: GSC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GSC (see all 4)
    OriGene shRNA RFP: GSC
    OriGene siRNA: GSC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GSC
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GSC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GSC (NM_005315)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GSC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GSC 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GSC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GSC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSC

    Additional cDNA sequence: 

    AY177407.1 BC063580.1 

    2 DOTS entries:

    DT.100018623  DT.100660023 

    11 AceView cDNA sequences:

    AY177407 BC063580 CA414748 NM_173849 BQ771765 BQ446670 AI758825 BQ772276 
    AW138807 BX091000 CB219115 

    GeneLoc Exon Structure


    Expression
    for GSC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GSC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACGTGGGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GSC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVascular AdiposeStromal Vascular Preadipocyte Progenitor CellsAdipose
    Primitive StreakAnterior Primitive StreakAnterior Primitive Streak CellsEarly Embryo
    EpiblastEpiblastEarly-Gastrula OrganizerEarly Embryo
    Neural TubeMesencephalic Floor PlateEarly Floor Plate CellsNeural Ectoderm
    Neural TubeMesencephalic Floor PlateLate Floor Plate CellsNeural Ectoderm
    Primitive StreakPrechordal PlatePrechordal Plate CellsEarly Embryo
    Primitive StreakPrimitive NodePrimitive Node CellsEarly Embryo
    Primitive StreakPrimitive StreakMesendoderm CellsEarly Embryo
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14) 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Primitive Streak Mesendoderm cells (Direct differentiati...)
    Primitive streak-like cells (Generation of primit...)
    Definitive endoderm-like cells (Generation and expan...)
    Definitive endoderm-like cells (Generation of mesend...)
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Mesendoderm-like cells (A scalable, suspensi...)
    Primitive streak-like cells (Generation of endode...)
    Mesendoderm-like cells (Generation of interm...)

    See GSC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GSC

    SOURCE GeneReport for Unigene cluster: Hs.440438
        SABiosciences Expression via Pathway-Focused PCR Arrays including GSC: 
              TGFB/BMP Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GSC
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for GSC

    Orthologs
    for GSC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GSC gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GSC1 goosecoid homeobox 82.04(n)
    89.8(a)    		   396273  NM_205331.1  NP_990662.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GSC6
    		 --
    		 82(a)
    		 1 ↔ 1
    		 1(6723368-6736769)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3977482 homeobox protein 75.48(n)    M81481.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gsc2 goosecoid 75.22(n)   30212  L03395.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gsc6
    		 Goosecoid
    		 13(a)
    		 1 → many
    		 2L(583540-594810)
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-456
    		 Homeobox family member (ceh-45)
    		 19(a)
    		 1 → many
    		 I(1128327-1131740)


    ENSEMBL Gene Tree for GSC (if available)
    TreeFam Gene Tree for GSC (if available) 

    Paralogs
    for GSC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GSC gene
    OTX22  HESX12  PROP12  ARGFX2  DMBX12  GSC22  SEBOX2  OTX12  
    CRX2  MIXL12  
    3 SIMAP similar genes for GSC using alignment to 1 protein entry:     GSC_HUMAN:
    HESX1    POU6F1    GSC2

    GSC for paralogs           About GeneDecksing



    Genomic Variants
    for GSC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/53 NCBI SNPs in GSC are shown (see all 53)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs45114631,2
    		C,F,A,H,--95234173(+) AGCTTG/AGAGCA 1 -- ds500128Minor allele frequency- A:0.34NA NS EA WA CSA 2907
    rs1908543571,2
    		--95234345(+) AAACCC/TTCCTA 1 -- ds50010--------
    rs1826893951,2
    		--95234374(+) AAACCA/GGGACA 1 -- ds50010--------
    rs38504011,2
    		C,F,A,--95234442(+) GATCAG/TAGCTG 1 -- ds500114Minor allele frequency- T:0.36NA WA CSA EA 516
    rs38504021,2
    		C,F,A,--95234452(+) GCTCAA/GTTTTT 1 -- ds500112Minor allele frequency- G:0.36NA WA CSA EA 512
    rs1388679991,2
    		--95234753(+) CGTGTG/TCAAGA 1 -- ut310--------
    rs1998916551,2
    		--95234861(+) CCTTCC/TTCTTC 2 E syn10--------
    rs1414525131,2
    		--95234968(+) GCGGC-/GGGTTC 2 RR RPR fra10--------
    rs2021264391,2
    		--95235015(+) CAGTTC/TAGATC 1 -- int10--------
    rs2015175301,2
    		--95235026(+) AAAGGA/CGCGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GSC (95234553 - 95236562 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for GSC: --
    Human Gene Mutation Database (HGMD): GSC

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GSC
    DNA2.0 Custom Variant and Variant Library Synthesis for GSC

    Disorders / Diseases
    for GSC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GSC for disorders           About GeneDecksing

    OMIM gene information: 138890    OMIM disorders: --

    7 diseases for GSC:    About MalaCards
    cornelia de lange syndrome    guillain-barre syndrome    auditory neuropathy    microtia
    velocardiofacial syndrome    digeorge syndrome    neuropathy

    2 diseases from the University of Copenhagen DISEASES database for GSC:
    Malignant glioma     Miller Fisher syndrome
    Human Genome Epidemiology (HuGE) Navigator: GSC (4 documents)

    Export disorders for GSC gene to outside databases

    Publications
    for GSC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GSC gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with GSC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1. (PubMed id 7916327)1, 2, 3, 9 Blum M.... Sparkes R.S. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Environmental and genetic factors associated with con genital microtia: a case-control study in Jiangsu, China, 2004 to 2007. (PubMed id 19935299)1, 9 Zhang Q.G....Shen H. (2009)
    4. Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. (PubMed id 12642491)1, 9 Foucher I....Trembleau A. (2003)
    5. EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differe ntiation by directly repressing GOOSECOID expression. (PubMed id 22178155)1 Kalisz M....Serup P. (2012)
    6. Evaluation of four novel genetic variants affecting h emoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 st udy). (PubMed id 21294870)1 Hertel J.K....RA (2011)
    7. Pedigree and genetic study of a bilateral congenital microtia family. (PubMed id 20195123)1 Zhang Q....Yin W. (2010)
    8. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)1 Paterson A.D....Bull S.B. (2010)
    9. A child with deletion (14)(q24.3q32.13) and auditory neuropathy. (PubMed id 18074379)1 Schlade-Bartusiak K....Cox D.W. (2008)
    10. The Spemann organizer gene, Goosecoid, promotes tumor metastasis. (PubMed id 17142318)1 Hartwell K.A....Weinberg R.A. (2006)

    External Searches for GSC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing GSC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 145258 HGNC: 4612 AceView: GSC Ensembl:ENSG00000133937 euGenes: HUgn145258
    ECgene: GSC H-InvDB: GSC

    Other Databases showing GSC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GSC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GSC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GSC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GSC gene:
    Search GeneIP for patents involving GSC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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