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Aliases for GRWD1 Gene

Aliases for GRWD1 Gene

  • Glutamate-Rich WD Repeat Containing 1 2 3
  • WDR28 3 4
  • GRWD 3 4
  • Regulator Of Ribosome Biogenesis 1 Homolog (S. Cerevisiae) 2
  • Regulator Of Ribosome Biogenesis 1 Homolog 3
  • CUL4- And DDB1-Associated WDR Protein 4 3
  • Glutamate Rich WD Repeat Protein GRWD 3
  • WD Repeat Domain 28 3
  • KIAA1942 4
  • CDW4 3
  • RRB1 3

External Ids for GRWD1 Gene

Previous GeneCards Identifiers for GRWD1 Gene

  • GC19P053640
  • GC19P048949
  • GC19P045329

Summaries for GRWD1 Gene

Entrez Gene Summary for GRWD1 Gene

  • This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]

GeneCards Summary for GRWD1 Gene

GRWD1 (Glutamate-Rich WD Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for GRWD1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRWD1 Gene

Genomics for GRWD1 Gene

Regulatory Elements for GRWD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRWD1 Gene

Chromosome:
19
Start:
48,445,773 bp from pter
End:
48,457,022 bp from pter
Size:
11,250 bases
Orientation:
Plus strand

Genomic View for GRWD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GRWD1 Gene

Proteins for GRWD1 Gene

  • Protein details for GRWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ67-GRWD1_HUMAN
    Recommended name:
    Glutamate-rich WD repeat-containing protein 1
    Protein Accession:
    Q9BQ67
    Secondary Accessions:
    • Q8TF59

    Protein attributes for GRWD1 Gene

    Size:
    446 amino acids
    Molecular mass:
    49419 Da
    Quaternary structure:
    • Interacts with METTL18.

neXtProt entry for GRWD1 Gene

Proteomics data for GRWD1 Gene at MOPED

Post-translational modifications for GRWD1 Gene

  • Ubiquitination at Lys 172, Lys 237, Lys 297, and Lys 333
  • Modification sites at PhosphoSitePlus

Other Protein References for GRWD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRWD1 Gene

Domains & Families for GRWD1 Gene

Gene Families for GRWD1 Gene

Suggested Antigen Peptide Sequences for GRWD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ67

UniProtKB/Swiss-Prot:

GRWD1_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with GRWD1: view

Function for GRWD1 Gene

Gene Ontology (GO) - Molecular Function for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GRWD1: view
genes like me logo Genes that share phenotypes with GRWD1: view

Animal Model Products

miRNA for GRWD1 Gene

miRTarBase miRNAs that target GRWD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRWD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GRWD1 Gene

Localization for GRWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRWD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRWD1 Gene COMPARTMENTS Subcellular localization image for GRWD1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GRWD1: view

Pathways & Interactions for GRWD1 Gene

SuperPathways for GRWD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRWD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRWD1 Gene

Drugs & Compounds for GRWD1 Gene

No Compound Related Data Available

Transcripts for GRWD1 Gene

mRNA/cDNA for GRWD1 Gene

Unigene Clusters for GRWD1 Gene

Glutamate-rich WD repeat containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRWD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRWD1 Gene

No ASD Table

Relevant External Links for GRWD1 Gene

GeneLoc Exon Structure for
GRWD1
ECgene alternative splicing isoforms for
GRWD1

Expression for GRWD1 Gene

mRNA expression in normal human tissues for GRWD1 Gene

Protein differential expression in normal tissues from HIPED for GRWD1 Gene

This gene is overexpressed in Pancreas (11.5), Peripheral blood mononuclear cells (10.4), and Lung (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRWD1 Gene



SOURCE GeneReport for Unigene cluster for GRWD1 Gene Hs.400625

genes like me logo Genes that share expression patterns with GRWD1: view

Protein tissue co-expression partners for GRWD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRWD1 Gene

Orthologs for GRWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRWD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRWD1 35
  • 90.88 (n)
  • 93.05 (a)
GRWD1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRWD1 35
  • 88.71 (n)
  • 92.27 (a)
GRWD1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grwd1 35
  • 87 (n)
  • 91.48 (a)
Grwd1 16
Grwd1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRWD1 35
  • 99.6 (n)
  • 99.76 (a)
GRWD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grwd1 35
  • 86.82 (n)
  • 91.46 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia GRWD1 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRWD1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grwd1 35
  • 66.67 (n)
  • 69.77 (a)
MGC76117 35
African clawed frog
(Xenopus laevis)
Amphibia grwd-pending-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16542 35
grwd1 35
  • 64.93 (n)
  • 64.54 (a)
grwd1 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5026 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007125 35
  • 59.14 (n)
  • 53.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)09851 35
  • 56.75 (n)
  • 56.67 (a)
l(2)09851 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54H5A.1 35
  • 50.49 (n)
  • 46.34 (a)
Y54H5A.1 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR242C 35
  • 49.8 (n)
  • 38.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17237g 35
  • 46.27 (n)
  • 39.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRB1 35
  • 44.68 (n)
  • 38.77 (a)
RRB1 36
  • 31 (a)
OneToOne
RRB1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G19540 35
  • 50.43 (n)
  • 45.24 (a)
rice
(Oryza sativa)
Liliopsida Os11g0134500 35
  • 51.04 (n)
  • 48.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2566 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09521 35
  • 52.58 (n)
  • 43.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.07 35
  • 48.45 (n)
  • 42.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for GRWD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRWD1 Gene

ENSEMBL:
Gene Tree for GRWD1 (if available)
TreeFam:
Gene Tree for GRWD1 (if available)

Paralogs for GRWD1 Gene

(1) SIMAP similar genes for GRWD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GRWD1: view

No data available for Paralogs for GRWD1 Gene

Variants for GRWD1 Gene

Sequence variations from dbSNP and Humsavar for GRWD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs929743 -- 48,446,509(-) CTCGG(C/G)TCTTA intron-variant
rs1619040 -- 48,452,096(-) AAAAA(A/G)AAAAA intron-variant
rs1628806 -- 48,449,417(-) TGCTG(A/G)CTACA intron-variant
rs1629621 -- 48,449,334(-) agggc(A/G)gactg intron-variant
rs1629664 -- 48,447,269(-) acttc(A/G)tctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRWD1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912219 CNV Loss 21882294
nsv828572 CNV Loss 20364138
nsv912220 CNV Loss 21882294
nsv912221 CNV Loss 21882294
nsv912222 CNV Loss 21882294
nsv912223 CNV Loss 21882294

Variation tolerance for GRWD1 Gene

Residual Variation Intolerance Score: 58.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.02; 87.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRWD1 Gene

HapMap Linkage Disequilibrium report
GRWD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRWD1 Gene

Disorders for GRWD1 Gene

Relevant External Links for GRWD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRWD1
genes like me logo Genes that share disorders with GRWD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRWD1 Gene

Publications for GRWD1 Gene

  1. The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis. (PMID: 15885502) Gratenstein K. … Fletcher B.S. (Genomics 2005) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 67
  4. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 67
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 67

Products for GRWD1 Gene

Sources for GRWD1 Gene

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