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Aliases for GRWD1 Gene

Aliases for GRWD1 Gene

  • Glutamate Rich WD Repeat Containing 1 2 3 5
  • WDR28 3 4
  • GRWD 3 4
  • Regulator Of Ribosome Biogenesis 1 Homolog (S. Cerevisiae) 2
  • Glutamate-Rich WD Repeat-Containing Protein 1 3
  • Regulator Of Ribosome Biogenesis 1 Homolog 3
  • CUL4- And DDB1-Associated WDR Protein 4 3
  • Glutamate Rich WD Repeat Protein GRWD 3
  • WD Repeat Domain 28 3
  • KIAA1942 4
  • CDW4 3
  • RRB1 3

External Ids for GRWD1 Gene

Previous GeneCards Identifiers for GRWD1 Gene

  • GC19P053640
  • GC19P048949
  • GC19P045329

Summaries for GRWD1 Gene

Entrez Gene Summary for GRWD1 Gene

  • This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]

GeneCards Summary for GRWD1 Gene

GRWD1 (Glutamate Rich WD Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for GRWD1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRWD1 Gene

Genomics for GRWD1 Gene

Regulatory Elements for GRWD1 Gene

Enhancers for GRWD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F048988 1.8 FANTOM5 Ensembl ENCODE 54.7 +546.3 546281 7.2 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GRWD1 TEAD2 NUP62 AKT1S1 KDELR1 ENSG00000268157 SNORD35A LOC101059948 PLEKHA4 PRR12
GH19F048328 1.4 FANTOM5 ENCODE 45.2 -114.1 -114108 5.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 GRWD1 KDELR1 GLTSCR2-AS1 TMEM143 EHD2 GLTSCR1 PLEKHA4 SYNGR4 EMP3 RASIP1
GH19F048612 1.2 ENCODE 52.6 +171.0 170990 7.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 KDELR1 GRWD1 PRR12 SNORD35A ENSG00000269321 ALDH16A1 SNORD35B TEAD2 RPS11 RPL18
GH19F048780 1.3 Ensembl ENCODE 47.5 +335.9 335915 3.0 PKNOX1 ARNT ZFP64 ARID4B CBX5 ZNF143 FOS KLF13 SP5 JUNB PRR12 GRWD1 CYTH2 SNORD35A PIH1D1 KDELR1 ENSG00000268093 SNORD35B ALDH16A1 RPS11
GH19F048588 1.7 FANTOM5 Ensembl ENCODE 34.9 +143.4 143435 1.2 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 CBX5 ZNF416 ZNF143 GRWD1 SNORD35A SULT2B1 KDELR1 GLTSCR2-AS1 ALDH16A1 GLTSCR1 SNORD35B EHD2 SNORD23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRWD1 on UCSC Golden Path with GeneCards custom track

Promoters for GRWD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000347974 127 1801 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143

Genomic Location for GRWD1 Gene

Chromosome:
19
Start:
48,445,773 bp from pter
End:
48,457,022 bp from pter
Size:
11,250 bases
Orientation:
Plus strand

Genomic View for GRWD1 Gene

Genes around GRWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRWD1 Gene

Proteins for GRWD1 Gene

  • Protein details for GRWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ67-GRWD1_HUMAN
    Recommended name:
    Glutamate-rich WD repeat-containing protein 1
    Protein Accession:
    Q9BQ67
    Secondary Accessions:
    • Q8TF59

    Protein attributes for GRWD1 Gene

    Size:
    446 amino acids
    Molecular mass:
    49419 Da
    Quaternary structure:
    • Interacts with METTL18.

neXtProt entry for GRWD1 Gene

Post-translational modifications for GRWD1 Gene

  • Ubiquitination at Lys 172, Lys 237, Lys 297, and Lys 333
  • Modification sites at PhosphoSitePlus

Other Protein References for GRWD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRWD1 Gene

Domains & Families for GRWD1 Gene

Gene Families for GRWD1 Gene

Suggested Antigen Peptide Sequences for GRWD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ67

UniProtKB/Swiss-Prot:

GRWD1_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with GRWD1: view

Function for GRWD1 Gene

Gene Ontology (GO) - Molecular Function for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GRWD1: view
genes like me logo Genes that share phenotypes with GRWD1: view

Animal Model Products

miRNA for GRWD1 Gene

miRTarBase miRNAs that target GRWD1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRWD1 Gene

Localization for GRWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRWD1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRWD1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GRWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GRWD1: view

Pathways & Interactions for GRWD1 Gene

SuperPathways for GRWD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GRWD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRWD1 Gene

Transcripts for GRWD1 Gene

mRNA/cDNA for GRWD1 Gene

Unigene Clusters for GRWD1 Gene

Glutamate-rich WD repeat containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRWD1 Gene

No ASD Table

Relevant External Links for GRWD1 Gene

GeneLoc Exon Structure for
GRWD1
ECgene alternative splicing isoforms for
GRWD1

Expression for GRWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRWD1 Gene

Protein differential expression in normal tissues from HIPED for GRWD1 Gene

This gene is overexpressed in Pancreas (11.5), Peripheral blood mononuclear cells (10.4), and Lung (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRWD1 Gene



Protein tissue co-expression partners for GRWD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRWD1 Gene:

GRWD1

SOURCE GeneReport for Unigene cluster for GRWD1 Gene:

Hs.400625
genes like me logo Genes that share expression patterns with GRWD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRWD1 Gene

Orthologs for GRWD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRWD1 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia GRWD1 34 35
  • 90.88 (n)
dog
(Canis familiaris)
Mammalia GRWD1 34 35
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Grwd1 34 16 35
  • 87 (n)
rat
(Rattus norvegicus)
Mammalia Grwd1 34
  • 86.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRWD1 35
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRWD1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grwd1 34
  • 66.67 (n)
MGC76117 34
African clawed frog
(Xenopus laevis)
Amphibia grwd-pending-prov 34
zebrafish
(Danio rerio)
Actinopterygii grwd1 34 35
  • 64.93 (n)
Dr.16542 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5026 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007125 34
  • 59.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)09851 34 35
  • 56.75 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54H5A.1 34
  • 50.49 (n)
Y54H5A.1 35
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR242C 34
  • 49.8 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17237g 34
  • 46.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRB1 34 35 37
  • 44.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G19540 34
  • 50.43 (n)
rice
(Oryza sativa)
Liliopsida Os11g0134500 34
  • 51.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU09521 34
  • 52.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1711.07 34
  • 48.45 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2566 34
Species where no ortholog for GRWD1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRWD1 Gene

ENSEMBL:
Gene Tree for GRWD1 (if available)
TreeFam:
Gene Tree for GRWD1 (if available)

Paralogs for GRWD1 Gene

(1) SIMAP similar genes for GRWD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GRWD1: view

No data available for Paralogs for GRWD1 Gene

Variants for GRWD1 Gene

Sequence variations from dbSNP and Humsavar for GRWD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs147327994 Uncertain significance 48,450,437(+) CCTCC(A/G)GGATG reference, missense
rs10405931 -- 48,453,653(+) CCCAG(A/T)TTTGG utr-variant-3-prime
rs11083935 -- 48,449,693(+) gtgct(C/T)accca intron-variant
rs11083936 -- 48,449,728(+) AGGTG(A/G)GAGGA intron-variant
rs11083937 -- 48,449,791(+) ACTCC(A/G)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRWD1 Gene

Variant ID Type Subtype PubMed ID
nsv828572 CNV loss 20364138
nsv9739 CNV gain+loss 18304495

Variation tolerance for GRWD1 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.02; 87.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRWD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRWD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRWD1 Gene

Disorders for GRWD1 Gene

Relevant External Links for GRWD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRWD1

No disorders were found for GRWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRWD1 Gene

Publications for GRWD1 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis. (PMID: 15885502) Gratenstein K. … Fletcher B.S. (Genomics 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64

Products for GRWD1 Gene

Sources for GRWD1 Gene

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