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Aliases for GRSF1 Gene

Aliases for GRSF1 Gene

  • G-Rich RNA Sequence Binding Factor 1 2 3
  • GRSF-1 3 4

External Ids for GRSF1 Gene

Previous GeneCards Identifiers for GRSF1 Gene

  • GC04M071642
  • GC04M071925
  • GC04M072085
  • GC04M072151
  • GC04M072050
  • GC04M071681
  • GC04M067485

Summaries for GRSF1 Gene

Entrez Gene Summary for GRSF1 Gene

  • The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRSF1 Gene

GRSF1 (G-Rich RNA Sequence Binding Factor 1) is a Protein Coding gene. Among its related pathways are Infectious disease and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ESRP2.

UniProtKB/Swiss-Prot for GRSF1 Gene

  • Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRSF1 Gene

Genomics for GRSF1 Gene

Regulatory Elements for GRSF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRSF1 Gene

Chromosome:
4
Start:
70,815,782 bp from pter
End:
70,843,274 bp from pter
Size:
27,493 bases
Orientation:
Minus strand

Genomic View for GRSF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRSF1 Gene

Proteins for GRSF1 Gene

  • Protein details for GRSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12849-GRSF1_HUMAN
    Recommended name:
    G-rich sequence factor 1
    Protein Accession:
    Q12849
    Secondary Accessions:
    • B3KPW0
    • Q4W5S5
    • Q6ZST3
    • Q8IWD6
    • Q8NBD2

    Protein attributes for GRSF1 Gene

    Size:
    480 amino acids
    Molecular mass:
    53126 Da
    Quaternary structure:
    • Monomer. Found in a complex with DDX28, DHX30, FASTKD2 and FASTKD5 (PubMed:25683715). Interacts with the mitochondrial RNase P complex subunit TRMT10C/MRPP1.
    Miscellaneous:
    • Depletion of GRSF1 by siRNA results in a combined OXPHOS assembly defect, with the prominent loss of complexes I, III, IV, and V. It also leads to altered steady-state levels of mitochondrial rRNAs and mRNAs
    SequenceCaution:
    • Sequence=AAC95399.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=AAH40485.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAY40942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC03513.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAC86863.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=EAX05634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRSF1 Gene

    Alternative splice isoforms for GRSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRSF1 Gene

Proteomics data for GRSF1 Gene at MOPED

Post-translational modifications for GRSF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRSF1 Gene

No data available for DME Specific Peptides for GRSF1 Gene

Domains & Families for GRSF1 Gene

Gene Families for GRSF1 Gene

Protein Domains for GRSF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12849

UniProtKB/Swiss-Prot:

GRSF1_HUMAN :
  • Contains 3 RRM (RNA recognition motif) domains.
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with GRSF1: view

Function for GRSF1 Gene

Molecular function for GRSF1 Gene

GENATLAS Biochemistry:
G-rich RNA sequence binding factor 1
UniProtKB/Swiss-Prot Function:
Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.

Gene Ontology (GO) - Molecular Function for GRSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 8036161
GO:0003729 mRNA binding TAS 8036161
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GRSF1: view
genes like me logo Genes that share phenotypes with GRSF1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRSF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GRSF1 Gene

Localization for GRSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRSF1 Gene

Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269 PubMed:25683715}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRSF1 Gene COMPARTMENTS Subcellular localization image for GRSF1 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for GRSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8036161
GO:0005739 mitochondrion IDA --
GO:0035770 ribonucleoprotein granule IDA 25683715
GO:0042645 mitochondrial nucleoid IDA 25683715
genes like me logo Genes that share ontologies with GRSF1: view

Pathways & Interactions for GRSF1 Gene

genes like me logo Genes that share pathways with GRSF1: view

Interacting Proteins for GRSF1 Gene

Gene Ontology (GO) - Biological Process for GRSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation TAS 8036161
GO:0008033 tRNA processing IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0016331 morphogenesis of embryonic epithelium IEA --
genes like me logo Genes that share ontologies with GRSF1: view

No data available for SIGNOR curated interactions for GRSF1 Gene

Drugs & Compounds for GRSF1 Gene

No Compound Related Data Available

Transcripts for GRSF1 Gene

Unigene Clusters for GRSF1 Gene

G-rich RNA sequence binding factor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRSF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRSF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:
SP9:

Relevant External Links for GRSF1 Gene

GeneLoc Exon Structure for
GRSF1
ECgene alternative splicing isoforms for
GRSF1

Expression for GRSF1 Gene

mRNA expression in normal human tissues for GRSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GRSF1 Gene

This gene is overexpressed in Bone marrow stromal cell (7.9) and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRSF1 Gene



SOURCE GeneReport for Unigene cluster for GRSF1 Gene Hs.309763

genes like me logo Genes that share expression patterns with GRSF1: view

Protein tissue co-expression partners for GRSF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRSF1 Gene

Orthologs for GRSF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRSF1 35
  • 90.76 (n)
  • 93.33 (a)
GRSF1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRSF1 35
  • 92.24 (n)
  • 95.01 (a)
GRSF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grsf1 35
  • 87.68 (n)
  • 90.81 (a)
Grsf1 16
Grsf1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRSF1 35
  • 99.35 (n)
  • 99.14 (a)
GRSF1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grsf1 35
  • 86.08 (n)
  • 90.19 (a)
oppossum
(Monodelphis domestica)
Mammalia GRSF1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRSF1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRSF1 35
  • 62.12 (n)
  • 55.15 (a)
GRSF1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRSF1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grsf1 35
  • 62.4 (n)
  • 54.88 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
grsf1 35
  • 56.67 (n)
  • 48.21 (a)
grsf1 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6946 37
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for GRSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRSF1 Gene

ENSEMBL:
Gene Tree for GRSF1 (if available)
TreeFam:
Gene Tree for GRSF1 (if available)

Paralogs for GRSF1 Gene

Paralogs for GRSF1 Gene

(6) SIMAP similar genes for GRSF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with GRSF1: view

Variants for GRSF1 Gene

Sequence variations from dbSNP and Humsavar for GRSF1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_047537 -

Structural Variations from Database of Genomic Variants (DGV) for GRSF1 Gene

Variant ID Type Subtype PubMed ID
nsv829966 CNV Loss 17160897
nsv4381 CNV Insertion 18451855

Variation tolerance for GRSF1 Gene

Residual Variation Intolerance Score: 24.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRSF1 Gene

HapMap Linkage Disequilibrium report
GRSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRSF1 Gene

Disorders for GRSF1 Gene

Relevant External Links for GRSF1

Genetic Association Database (GAD)
GRSF1
Human Genome Epidemiology (HuGE) Navigator
GRSF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRSF1
genes like me logo Genes that share disorders with GRSF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRSF1 Gene

Publications for GRSF1 Gene

  1. GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element. (PMID: 8036161) Qian Z. … Wilusz J. (Nucleic Acids Res. 1994) 2 23 67
  2. Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis. (PMID: 12239318) Kash J.C. … Katze M.G. (J. Virol. 2002) 23 67
  3. Mitochondrial RNA granules are centers for posttranscriptional RNA processing and ribosome biogenesis. (PMID: 25683715) Antonicka H. … Shoubridge E.A. (Cell Rep. 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67

Products for GRSF1 Gene

Sources for GRSF1 Gene

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