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Aliases for GRPR Gene

Aliases for GRPR Gene

  • Gastrin Releasing Peptide Receptor 2 3 5
  • GRP-Preferring Bombesin Receptor 3 4
  • Bombesin Receptor 2 2 3
  • GRP-R 3 4
  • BB2 3

External Ids for GRPR Gene

Previous GeneCards Identifiers for GRPR Gene

  • GC0XP015862
  • GC0XP014967
  • GC0XP015343
  • GC0XP015503
  • GC0XP015901
  • GC0XP016051
  • GC0XP013896

Summaries for GRPR Gene

Entrez Gene Summary for GRPR Gene

  • Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRPR Gene

GRPR (Gastrin Releasing Peptide Receptor) is a Protein Coding gene. Diseases associated with GRPR include Agoraphobia and Lung Cancer. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for GRPR Gene

  • Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for GRPR Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for GRPR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRPR Gene

Genomics for GRPR Gene

Regulatory Elements for GRPR Gene

Enhancers for GRPR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRPR on UCSC Golden Path with GeneCards custom track

Genomic Location for GRPR Gene

Chromosome:
X
Start:
16,123,301 bp from pter
End:
16,153,518 bp from pter
Size:
30,218 bases
Orientation:
Plus strand

Genomic View for GRPR Gene

Genes around GRPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRPR Gene

Proteins for GRPR Gene

  • Protein details for GRPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30550-GRPR_HUMAN
    Recommended name:
    Gastrin-releasing peptide receptor
    Protein Accession:
    P30550
    Secondary Accessions:
    • B2R910

    Protein attributes for GRPR Gene

    Size:
    384 amino acids
    Molecular mass:
    43199 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GRPR Gene

Proteomics data for GRPR Gene at MOPED

Post-translational modifications for GRPR Gene

  • Glycosylation at Asn 20
  • Modification sites at PhosphoSitePlus

Other Protein References for GRPR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRPR Gene

Domains & Families for GRPR Gene

Gene Families for GRPR Gene

Suggested Antigen Peptide Sequences for GRPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30550

UniProtKB/Swiss-Prot:

GRPR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GRPR: view

Function for GRPR Gene

Molecular function for GRPR Gene

GENATLAS Biochemistry:
gastrin releasing peptide receptor
UniProtKB/Swiss-Prot Function:
Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004946 bombesin receptor activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with GRPR: view
genes like me logo Genes that share phenotypes with GRPR: view

Human Phenotype Ontology for GRPR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GRPR Gene

MGI Knock Outs for GRPR:

Animal Model Products

miRNA for GRPR Gene

miRTarBase miRNAs that target GRPR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRPR Gene

Localization for GRPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRPR Gene COMPARTMENTS Subcellular localization image for GRPR gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for GRPR Gene

Pathways & Interactions for GRPR Gene

genes like me logo Genes that share pathways with GRPR: view

SIGNOR curated interactions for GRPR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031989 bombesin receptor signaling pathway IEA --
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with GRPR: view

Drugs & Compounds for GRPR Gene

(37) Drugs for GRPR Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bombesin Pharma Full agonist, Agonist Involved in gastrointestinal tract function 8
ranatensin Pharma Full agonist, Agonist 0
(D-Ala<sup>11</sup>]bombesin Pharma Full agonist, Agonist 0
[<sup>125</sup>I][Tyr<sup>4</sup>]bombesin Pharma Full agonist, Agonist 0
[<sup>125</sup>I]GRP (human) Pharma 0

(23) Additional Compounds for GRPR Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[(3-Ph-Pr<sup>6</sup>), His<sup>7</sup>,D-Ala<sup>11</sup>,D-Pro<sup>13</sup>,psi13-14),Phe<sup>14</sup>]bombesin-(6-14)
Antagonist
[D-Phe<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14)
Full agonist, Agonist
[D-Phe<sup>6</sup>,Cpa<sup>14</sup>,psi13-14]bombesin-(6-14)
Antagonist
[Leu<sup>14</sup>, psi 13-14)]bombesin
Antagonist
10-OBn-7alpha-F-gingkolide B
Full agonist, Agonist

(5) Tocris Compounds for GRPR Gene

Compound Action Cas Number
BA 1 Potent BRS-3 agonist; also NMBR and GRPR agonist 183241-31-8
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9
genes like me logo Genes that share compounds with GRPR: view

Transcripts for GRPR Gene

mRNA/cDNA for GRPR Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRPR Gene

Gastrin-releasing peptide receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRPR Gene

No ASD Table

Relevant External Links for GRPR Gene

GeneLoc Exon Structure for
GRPR
ECgene alternative splicing isoforms for
GRPR

Expression for GRPR Gene

mRNA expression in normal human tissues for GRPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRPR Gene

This gene is overexpressed in Pancreas (x18.2), Esophagus - Gastroesophageal Junction (x7.9), and Esophagus - Muscularis (x7.0).

SOURCE GeneReport for Unigene cluster for GRPR Gene Hs.567282

mRNA Expression by UniProt/SwissProt for GRPR Gene

P30550-GRPR_HUMAN
Tissue specificity: Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.
genes like me logo Genes that share expression patterns with GRPR: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GRPR Gene

Orthologs for GRPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GRPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRPR 35
  • 90.71 (n)
  • 92.97 (a)
GRPR 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRPR 35
  • 90.54 (n)
  • 94.27 (a)
GRPR 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grpr 35
  • 87.73 (n)
  • 90.34 (a)
Grpr 16
Grpr 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRPR 35
  • 99.39 (n)
  • 99.48 (a)
GRPR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grpr 35
  • 87.64 (n)
  • 90.08 (a)
oppossum
(Monodelphis domestica)
Mammalia GRPR 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRPR 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRPR 35
  • 77.6 (n)
  • 82.55 (a)
GRPR 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRPR 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grpr 35
  • 72.11 (n)
  • 78.16 (a)
zebrafish
(Danio rerio)
Actinopterygii grpr 35
  • 71.47 (n)
  • 75.88 (a)
grpr 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30106 37
  • 37 (a)
CCHa1r 36
  • 27 (a)
ManyToMany
CCHa2r 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK455.3 37
  • 29 (a)
Species with no ortholog for GRPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRPR Gene

ENSEMBL:
Gene Tree for GRPR (if available)
TreeFam:
Gene Tree for GRPR (if available)

Paralogs for GRPR Gene

Paralogs for GRPR Gene

(7) SIMAP similar genes for GRPR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRPR: view

Variants for GRPR Gene

Sequence variations from dbSNP and Humsavar for GRPR Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747787490 -- 16,122,899(+) CTCCC(C/T)GGTAA upstream-variant-2KB
rs747979337 -- 16,145,258(+) GTCCA(C/T)CAACA intron-variant
rs748153348 -- 16,135,160(+) CCTGC(C/T)GCAGG intron-variant
rs748292383 -- 16,124,956(+) GAAAT(C/T)AAACA intron-variant
rs748364809 -- 16,146,066(+) AGCAA(C/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRPR Gene

Variant ID Type Subtype PubMed ID
nsv436917 CNV Insertion 17901297

Variation tolerance for GRPR Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRPR Gene

Human Gene Mutation Database (HGMD)
GRPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRPR Gene

Disorders for GRPR Gene

MalaCards: The human disease database

(6) MalaCards diseases for GRPR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
agoraphobia
  • fear of open spaces
lung cancer
  • lung cancer, protection against
prostate cancer
  • prostate cancer, hereditary, 5
rett syndrome
  • rett syndrome, preserved speech variant
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GRPR in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRPR

Genetic Association Database (GAD)
GRPR
Human Genome Epidemiology (HuGE) Navigator
GRPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRPR
genes like me logo Genes that share disorders with GRPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRPR Gene

Publications for GRPR Gene

  1. Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism. (PMID: 14729406) Marui T. … Sasaki T. (Brain Dev. 2004) 3 23 48 67
  2. BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cells. (PMID: 19642024) Schmidt A.L. … Roesler R. (J. Mol. Neurosci. 2010) 3 23
  3. Gastrin-releasing peptide receptor content in human glioma and normal brain. (PMID: 20211708) Flores D.G. … Roesler R. (Brain Res. Bull. 2010) 3 23
  4. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PMID: 18452185) Hodges L.M. … Hamilton S.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23
  5. Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer. (PMID: 19343734) Ananias H.J. … de Jong I.J. (Prostate 2009) 3 23

Products for GRPR Gene

Sources for GRPR Gene

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