Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRPR Gene

Aliases for GRPR Gene

  • Gastrin Releasing Peptide Receptor 2 3 5
  • GRP-Preferring Bombesin Receptor 3 4
  • Bombesin Receptor 2 2 3
  • GRP-R 3 4
  • Gastrin-Releasing Peptide Receptor 3
  • BB2R 3
  • BB2 3

External Ids for GRPR Gene

Previous GeneCards Identifiers for GRPR Gene

  • GC0XP015862
  • GC0XP014967
  • GC0XP015343
  • GC0XP015503
  • GC0XP015901
  • GC0XP016051
  • GC0XP013896

Summaries for GRPR Gene

Entrez Gene Summary for GRPR Gene

  • Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRPR Gene

GRPR (Gastrin Releasing Peptide Receptor) is a Protein Coding gene. Diseases associated with GRPR include Agoraphobia and Prostate Adenocarcinoma. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is NMBR.

UniProtKB/Swiss-Prot for GRPR Gene

  • Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for GRPR Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for GRPR Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRPR Gene

Genomics for GRPR Gene

Regulatory Elements for GRPR Gene

Enhancers for GRPR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG016185 1.3 Ensembl ENCODE dbSUPER 12.9 +63.2 63213 2.8 PKNOX1 ZNF146 ATF1 JUN CHD7 RAD21 FOSL1 ZNF316 NR2F6 NFE2 GRPR ZRSR2 RPL6P30 LOC102724124
GH0XG015988 0.9 Ensembl ENCODE 12 -134.0 -133997 1.4 FOSL1 JUND EED JUN IKZF1 FOS EBF1 IKZF2 SPI1 GRPR ZRSR2 PIR40959 SETP15
GH0XG016100 0.8 ENCODE 12.6 -22.3 -22291 1.8 ZSCAN4 ZNF766 CBX5 ETV6 RELB IKZF2 MCM3 NCOA1 JUNB GATAD2B ZRSR2 GRPR PIR40959
GH0XG016211 0.6 dbSUPER 12 +88.9 88886 0.6 CTCF JUND SMC3 FOS REST RAD21 MAGEB17 LOC102724124 GRPR ZRSR2 RPL6P30 GC0XP016374
GH0XG015930 0.6 ENCODE 11.3 -192.5 -192509 0.2 CTCF GLIS1 HLF SMC3 REST RAD21 GRPR SETP15 PIR40959
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRPR on UCSC Golden Path with GeneCards custom track

Genomic Location for GRPR Gene

Chromosome:
X
Start:
16,123,301 bp from pter
End:
16,153,518 bp from pter
Size:
30,218 bases
Orientation:
Plus strand

Genomic View for GRPR Gene

Genes around GRPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRPR Gene

Proteins for GRPR Gene

  • Protein details for GRPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30550-GRPR_HUMAN
    Recommended name:
    Gastrin-releasing peptide receptor
    Protein Accession:
    P30550
    Secondary Accessions:
    • B2R910

    Protein attributes for GRPR Gene

    Size:
    384 amino acids
    Molecular mass:
    43199 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GRPR Gene

Post-translational modifications for GRPR Gene

  • Glycosylation at isoforms=20
  • Modification sites at PhosphoSitePlus

Other Protein References for GRPR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRPR Gene

Domains & Families for GRPR Gene

Gene Families for GRPR Gene

Suggested Antigen Peptide Sequences for GRPR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30550

UniProtKB/Swiss-Prot:

GRPR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GRPR: view

Function for GRPR Gene

Molecular function for GRPR Gene

GENATLAS Biochemistry:
gastrin releasing peptide receptor
UniProtKB/Swiss-Prot Function:
Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008188 neuropeptide receptor activity ISS --
GO:0008528 G-protein coupled peptide receptor activity IDA,TAS 1655761
genes like me logo Genes that share ontologies with GRPR: view
genes like me logo Genes that share phenotypes with GRPR: view

Animal Models for GRPR Gene

MGI Knock Outs for GRPR:

Animal Model Products

miRNA for GRPR Gene

miRTarBase miRNAs that target GRPR

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GRPR
  • R&D Systems cDNA Clones for GRPR (Gastrin-releasing Peptide R/GRPR)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRPR Gene

Localization for GRPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRPR gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRPR: view

Pathways & Interactions for GRPR Gene

genes like me logo Genes that share pathways with GRPR: view

SIGNOR curated interactions for GRPR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GRPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 1655761
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0008283 cell proliferation TAS 1655761
genes like me logo Genes that share ontologies with GRPR: view

Drugs & Compounds for GRPR Gene

(42) Drugs for GRPR Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bombesin Pharma Full agonist, Agonist Involved in gastrointestinal tract function 9
PD 176252 Pharma Antagonist GRP (BB2) and NMB (BB1) receptor antagonist 0
ranatensin Pharma Full agonist, Agonist 0
(D-Ala<sup>11</sup>]bombesin Pharma Full agonist, Agonist 0
[<sup>125</sup>I][Tyr<sup>4</sup>]bombesin Pharma Full agonist, Agonist 0

(18) Additional Compounds for GRPR Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[(3-Ph-Pr<sup>6</sup>), His<sup>7</sup>,D-Ala<sup>11</sup>,D-Pro<sup>13</sup>,psi13-14),Phe<sup>14</sup>]bombesin-(6-14)
Antagonist
[D-Phe<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14)
Full agonist, Agonist
[D-Phe<sup>6</sup>,Cpa<sup>14</sup>,psi13-14]bombesin-(6-14)
Antagonist
[Leu<sup>14</sup>, psi 13-14)]bombesin
Antagonist
10-OBn-7alpha-F-gingkolide B
Full agonist, Agonist

(5) Tocris Compounds for GRPR Gene

Compound Action Cas Number
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9
Neuromedin B (porcine) Mammalian bombesin-like peptide 87096-84-2
PD 176252 GRP (BB2) and NMB (BB1) receptor antagonist 204067-01-6

(1) ApexBio Compounds for GRPR Gene

Compound Action Cas Number
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
genes like me logo Genes that share compounds with GRPR: view

Drug Products

Transcripts for GRPR Gene

mRNA/cDNA for GRPR Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRPR Gene

Gastrin-releasing peptide receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GRPR
  • R&D Systems cDNA Clones for GRPR (Gastrin-releasing Peptide R/GRPR)

Alternative Splicing Database (ASD) splice patterns (SP) for GRPR Gene

No ASD Table

Relevant External Links for GRPR Gene

GeneLoc Exon Structure for
GRPR
ECgene alternative splicing isoforms for
GRPR

Expression for GRPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRPR Gene

This gene is overexpressed in Pancreas (x18.2), Esophagus - Gastroesophageal Junction (x7.9), and Esophagus - Muscularis (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of GRPR Gene:

GRPR

SOURCE GeneReport for Unigene cluster for GRPR Gene:

Hs.567282

mRNA Expression by UniProt/SwissProt for GRPR Gene:

P30550-GRPR_HUMAN
Tissue specificity: Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.

Evidence on tissue expression from TISSUES for GRPR Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with GRPR: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRPR Gene

Orthologs for GRPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GRPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRPR 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia GRPR 34 35
  • 90.71 (n)
dog
(Canis familiaris)
Mammalia GRPR 34 35
  • 90.54 (n)
mouse
(Mus musculus)
Mammalia Grpr 34 16 35
  • 87.73 (n)
rat
(Rattus norvegicus)
Mammalia Grpr 34
  • 87.64 (n)
oppossum
(Monodelphis domestica)
Mammalia GRPR 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRPR 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRPR 35 34
  • 77.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRPR 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grpr 34
  • 72.11 (n)
zebrafish
(Danio rerio)
Actinopterygii grpr 34 35
  • 71.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30106 36
  • 37 (a)
CCHa1r 35
  • 27 (a)
ManyToMany
CCHa2r 35
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK455.3 36
  • 29 (a)
Species where no ortholog for GRPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRPR Gene

ENSEMBL:
Gene Tree for GRPR (if available)
TreeFam:
Gene Tree for GRPR (if available)

Paralogs for GRPR Gene

Paralogs for GRPR Gene

(7) SIMAP similar genes for GRPR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRPR: view

Variants for GRPR Gene

Sequence variations from dbSNP and Humsavar for GRPR Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000029339 -- 16,137,552(+) GGCTC(A/C)TGTGA intron-variant
rs1000229914 -- 16,143,594(+) CCTTA(G/T)CTTCT intron-variant
rs1000341758 -- 16,122,794(+) TGCCG(A/G)TTCAT upstream-variant-2KB
rs1000447252 -- 16,131,596(+) ATTCT(A/T)TCATG intron-variant
rs1000458644 -- 16,131,927(+) TAAAT(A/G)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRPR Gene

Variant ID Type Subtype PubMed ID
nsv436917 CNV insertion 17901297

Variation tolerance for GRPR Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRPR Gene

Human Gene Mutation Database (HGMD)
GRPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRPR Gene

Disorders for GRPR Gene

MalaCards: The human disease database

(6) MalaCards diseases for GRPR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
agoraphobia
  • fear of open spaces
prostate adenocarcinoma
  • adenocarcinoma of prostate
prostate cancer
  • prostate cancer, hereditary, 5
lung cancer
  • lung cancer, protection against
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GRPR in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRPR

Genetic Association Database (GAD)
GRPR
Human Genome Epidemiology (HuGE) Navigator
GRPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRPR
genes like me logo Genes that share disorders with GRPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRPR Gene

Publications for GRPR Gene

  1. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PMID: 18452185) Hodges L.M. … Hamilton S.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 22 46 64
  2. Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism. (PMID: 14729406) Marui T. … Sasaki T. (Brain Dev. 2004) 3 22 46 64
  3. The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. (PMID: 11245983) Xiao D. … Weber H.C. (Gene 2001) 3 4 22 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cells. (PMID: 19642024) Schmidt A.L. … Roesler R. (J. Mol. Neurosci. 2010) 3 22 64

Products for GRPR Gene

  • Addgene plasmids for GRPR

Sources for GRPR Gene

Content
Loading form....