Aliases for GRPR Gene
External Ids for GRPR Gene
Previous GeneCards Identifiers for GRPR Gene
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRPR Gene
GRPR (Gastrin-Releasing Peptide Receptor) is a Protein Coding gene. Diseases associated with GRPR include agoraphobia and rett syndrome. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is EDNRB.
UniProtKB/Swiss-Prot for GRPR Gene
Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).