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Aliases for GRPEL2 Gene

Aliases for GRPEL2 Gene

  • GrpE Like 2, Mitochondrial 2 3 5
  • Mt-GrpE#2 3 4
  • GrpE Protein Homolog 2, Mitochondrial 3
  • GrpE-Like 2, Mitochondrial (E. Coli) 2

External Ids for GRPEL2 Gene

Previous GeneCards Identifiers for GRPEL2 Gene

  • GC05P148708
  • GC05P148753
  • GC05P148705
  • GC05P143872

Summaries for GRPEL2 Gene

GeneCards Summary for GRPEL2 Gene

GRPEL2 (GrpE Like 2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chaperone binding. An important paralog of this gene is GRPEL1.

UniProtKB/Swiss-Prot for GRPEL2 Gene

  • Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).

Additional gene information for GRPEL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRPEL2 Gene

Genomics for GRPEL2 Gene

GeneHancer (GH) Regulatory Elements for GRPEL2 Gene

Promoters and enhancers for GRPEL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I149343 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1283 6.4 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 PPARGC1A MEF2D ZNF610 GRPEL2 HMGXB3 ENSG00000251330 FBXO38 PCYOX1L RPL7P1 ENSG00000253865 RPS20P4 MIR143 MIR145
GH05I149319 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -22.8 -22816 6.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 HMGXB3 PCYOX1L RPL7P1 GRPEL2 ENSG00000251330 ENSG00000253865 GRPEL2-AS1 MIR145 AFAP1L1 MIR143
GH05I149367 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 +22.2 22165 0.8 HDGF ELF3 PKNOX1 FOXA2 ARID4B SIN3A ZSCAN9 RAD21 RARA SLC30A9 GRPEL2 MIR143 CARMN IL17B ENSG00000248647 ENSG00000253406 AFAP1L1 ENSG00000253865 PCYOX1L
GH05I149317 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.3 -28.0 -27955 0.3 CTCF ESRRA ARNT TEAD4 ZNF2 RAD21 CC2D1A POLR2A BRD9 ZNF143 AFAP1L1 RNU6-588P ENSG00000248647 ENSG00000253406 GC05M149307 GRPEL2
GH05I149340 Enhancer 0.3 ENCODE 0.8 -3.7 -3700 2.1 ZMYM3 PCYOX1L MIR143 ENSG00000248647 ENSG00000253406 CARMN IL17B GRPEL2 GC05M149307 AFAP1L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRPEL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRPEL2 gene promoter:

Genomic Locations for GRPEL2 Gene

Genomic Locations for GRPEL2 Gene
chr5:149,345,414-149,354,583
(GRCh38/hg38)
Size:
9,170 bases
Orientation:
Plus strand
chr5:148,724,977-148,734,146
(GRCh37/hg19)

Genomic View for GRPEL2 Gene

Genes around GRPEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRPEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRPEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRPEL2 Gene

Proteins for GRPEL2 Gene

  • Protein details for GRPEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAA5-GRPE2_HUMAN
    Recommended name:
    GrpE protein homolog 2, mitochondrial
    Protein Accession:
    Q8TAA5
    Secondary Accessions:
    • B4DFA6
    • Q49AJ6

    Protein attributes for GRPEL2 Gene

    Size:
    225 amino acids
    Molecular mass:
    25431 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19.

    Alternative splice isoforms for GRPEL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRPEL2 Gene

Post-translational modifications for GRPEL2 Gene

No Post-translational modifications

Other Protein References for GRPEL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRPEL2 Gene

Domains & Families for GRPEL2 Gene

Gene Families for GRPEL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRPEL2 Gene

Suggested Antigen Peptide Sequences for GRPEL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAA5

UniProtKB/Swiss-Prot:

GRPE2_HUMAN :
  • Belongs to the GrpE family.
Family:
  • Belongs to the GrpE family.
genes like me logo Genes that share domains with GRPEL2: view

Function for GRPEL2 Gene

Molecular function for GRPEL2 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).

Gene Ontology (GO) - Molecular Function for GRPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity IBA --
GO:0042803 protein homodimerization activity IEA --
GO:0051082 unfolded protein binding IBA --
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with GRPEL2: view
genes like me logo Genes that share phenotypes with GRPEL2: view

miRNA for GRPEL2 Gene

miRTarBase miRNAs that target GRPEL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRPEL2 Gene

Localization for GRPEL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRPEL2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRPEL2 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GRPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001405 presequence translocase-associated import motor IBA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with GRPEL2: view

Pathways & Interactions for GRPEL2 Gene

genes like me logo Genes that share pathways with GRPEL2: view

Pathways by source for GRPEL2 Gene

2 Reactome pathways for GRPEL2 Gene

Gene Ontology (GO) - Biological Process for GRPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GRPEL2: view

No data available for SIGNOR curated interactions for GRPEL2 Gene

Drugs & Compounds for GRPEL2 Gene

No Compound Related Data Available

Transcripts for GRPEL2 Gene

Unigene Clusters for GRPEL2 Gene

GrpE-like 2, mitochondrial (E. coli):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRPEL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for GRPEL2 Gene

GeneLoc Exon Structure for
GRPEL2
ECgene alternative splicing isoforms for
GRPEL2

Expression for GRPEL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRPEL2 Gene

mRNA differential expression in normal tissues according to GTEx for GRPEL2 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.0).

Protein differential expression in normal tissues from HIPED for GRPEL2 Gene

This gene is overexpressed in Cervix (58.5) and Bone (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRPEL2 Gene



Protein tissue co-expression partners for GRPEL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GRPEL2 Gene:

GRPEL2

SOURCE GeneReport for Unigene cluster for GRPEL2 Gene:

Hs.511816

Evidence on tissue expression from TISSUES for GRPEL2 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with GRPEL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRPEL2 Gene

Orthologs for GRPEL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRPEL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRPEL2 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia GRPEL2 33 34
  • 90.07 (n)
cow
(Bos Taurus)
Mammalia GRPEL2 33 34
  • 88.99 (n)
rat
(Rattus norvegicus)
Mammalia Grpel2 33
  • 86.31 (n)
mouse
(Mus musculus)
Mammalia Grpel2 33 16 34
  • 85.27 (n)
oppossum
(Monodelphis domestica)
Mammalia GRPEL2 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRPEL2 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRPEL2 33 34
  • 69.47 (n)
lizard
(Anolis carolinensis)
Reptilia GRPEL2 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grpel2 33
  • 61.88 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100004941 33
  • 57.98 (n)
grpel2 34
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Roe1 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34C12.8 34
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGE1 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6300 34
  • 31 (a)
OneToMany
Species where no ortholog for GRPEL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRPEL2 Gene

ENSEMBL:
Gene Tree for GRPEL2 (if available)
TreeFam:
Gene Tree for GRPEL2 (if available)

Paralogs for GRPEL2 Gene

Paralogs for GRPEL2 Gene

(2) SIMAP similar genes for GRPEL2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GRPEL2 Gene

genes like me logo Genes that share paralogs with GRPEL2: view

Variants for GRPEL2 Gene

Sequence variations from dbSNP and Humsavar for GRPEL2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000202482 -- 149,350,155(+) T/A intron_variant
rs1000280045 -- 149,346,326(+) T/C intron_variant
rs1000291378 -- 149,346,555(+) T/C intron_variant
rs1001071984 -- 149,345,353(+) C/G upstream_transcript_variant
rs1001248314 -- 149,352,234(+) TTTTTTTTT/TTTTTTTT/TTTTTTTTTT 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for GRPEL2 Gene

Variant ID Type Subtype PubMed ID
esv3607137 CNV gain 21293372
nsv599948 CNV loss 21841781

Variation tolerance for GRPEL2 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRPEL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRPEL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRPEL2 Gene

Disorders for GRPEL2 Gene

Additional Disease Information for GRPEL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GRPEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRPEL2 Gene

Publications for GRPEL2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. (PMID: 9694873) Naylor DJ … Høj PB (The Journal of biological chemistry 1998) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GRPEL2 Gene

Sources for GRPEL2 Gene

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