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Aliases for GRPEL2 Gene

Aliases for GRPEL2 Gene

  • GrpE Like 2, Mitochondrial 2 3 5
  • Mt-GrpE#2 3 4
  • GrpE Protein Homolog 2, Mitochondrial 3
  • GrpE-Like 2, Mitochondrial (E. Coli) 2

External Ids for GRPEL2 Gene

Previous GeneCards Identifiers for GRPEL2 Gene

  • GC05P148708
  • GC05P148753
  • GC05P148705
  • GC05P143872

Summaries for GRPEL2 Gene

GeneCards Summary for GRPEL2 Gene

GRPEL2 (GrpE Like 2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Metabolism of proteins. GO annotations related to this gene include protein homodimerization activity and chaperone binding. An important paralog of this gene is GRPEL1.

UniProtKB/Swiss-Prot for GRPEL2 Gene

  • Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRPEL2 Gene

Genomics for GRPEL2 Gene

Regulatory Elements for GRPEL2 Gene

Enhancers for GRPEL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F149319 1.2 FANTOM5 Ensembl ENCODE 12.1 -22.8 -22816 6.6 PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B DMAP1 YY1 CBX5 FOS PCYOX1L GRPEL2 LOC105378223 GRPEL2-AS1 MIR145 AFAP1L1 MIR143 CARMN IL17B RNU6-588P
GH05F149367 0.9 Ensembl ENCODE 11.5 +22.3 22265 1.0 HDGF PKNOX1 ARNT ARID4B SLC30A9 ZNF766 GATA2 ZNF143 MXD4 REST GRPEL2 MIR143 IL17B CARMN ENSG00000248647 ENSG00000253406 AFAP1L1 LOC105378223 PCYOX1L
GH05F149340 0.6 ENCODE 0.8 -3.7 -3701 2.1 GATA3 ZMYM3 MAFG NFE2 PCYOX1L MIR143 ENSG00000248647 ENSG00000253406 CARMN IL17B GRPEL2 GC05M149307
GH05F149343 1.1 ENCODE 0.8 +1.3 1284 6.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PCYOX1L CARMN ENSG00000248696 PDGFRB RPL7P1 LOC644762 LOC105378223 MIR143 MIR145 ENSG00000248647
GH05F149353 0.4 ENCODE 0.4 +9.2 9180 2.4 HDAC1 ZBTB40 RAD21 ZNF121 SCRT2 EGR2 SMARCA5 ZNF654 ELF1 REST PCYOX1L IL17B MIR143 CARMN AFAP1L1 GC05P149356 GRPEL2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GRPEL2 on UCSC Golden Path with GeneCards custom track

Promoters for GRPEL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001293517 286 2601 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for GRPEL2 Gene

Chromosome:
5
Start:
149,345,414 bp from pter
End:
149,354,583 bp from pter
Size:
9,170 bases
Orientation:
Plus strand

Genomic View for GRPEL2 Gene

Genes around GRPEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRPEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRPEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRPEL2 Gene

Proteins for GRPEL2 Gene

  • Protein details for GRPEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAA5-GRPE2_HUMAN
    Recommended name:
    GrpE protein homolog 2, mitochondrial
    Protein Accession:
    Q8TAA5
    Secondary Accessions:
    • B4DFA6
    • Q49AJ6

    Protein attributes for GRPEL2 Gene

    Size:
    225 amino acids
    Molecular mass:
    25431 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19.

    Alternative splice isoforms for GRPEL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRPEL2 Gene

Post-translational modifications for GRPEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRPEL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRPEL2 Gene

Domains & Families for GRPEL2 Gene

Protein Domains for GRPEL2 Gene

Suggested Antigen Peptide Sequences for GRPEL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TAA5

UniProtKB/Swiss-Prot:

GRPE2_HUMAN :
  • Belongs to the GrpE family.
Family:
  • Belongs to the GrpE family.
genes like me logo Genes that share domains with GRPEL2: view

No data available for Gene Families for GRPEL2 Gene

Function for GRPEL2 Gene

Molecular function for GRPEL2 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity).

Gene Ontology (GO) - Molecular Function for GRPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity IBA --
GO:0042803 protein homodimerization activity IEA --
GO:0051082 unfolded protein binding IBA --
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with GRPEL2: view
genes like me logo Genes that share phenotypes with GRPEL2: view

Animal Model Products

miRNA for GRPEL2 Gene

miRTarBase miRNAs that target GRPEL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRPEL2 Gene

Localization for GRPEL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRPEL2 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRPEL2 Gene COMPARTMENTS Subcellular localization image for GRPEL2 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GRPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001405 presequence translocase-associated import motor IBA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with GRPEL2: view

Pathways & Interactions for GRPEL2 Gene

genes like me logo Genes that share pathways with GRPEL2: view

Pathways by source for GRPEL2 Gene

2 Reactome pathways for GRPEL2 Gene

Gene Ontology (GO) - Biological Process for GRPEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GRPEL2: view

No data available for SIGNOR curated interactions for GRPEL2 Gene

Transcripts for GRPEL2 Gene

Unigene Clusters for GRPEL2 Gene

GrpE-like 2, mitochondrial (E. coli):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRPEL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for GRPEL2 Gene

GeneLoc Exon Structure for
GRPEL2
ECgene alternative splicing isoforms for
GRPEL2

Expression for GRPEL2 Gene

mRNA expression in normal human tissues for GRPEL2 Gene

mRNA differential expression in normal tissues according to GTEx for GRPEL2 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.0).

Protein differential expression in normal tissues from HIPED for GRPEL2 Gene

This gene is overexpressed in Cervix (58.5) and Bone (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRPEL2 Gene



Protein tissue co-expression partners for GRPEL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GRPEL2 Gene:

GRPEL2

SOURCE GeneReport for Unigene cluster for GRPEL2 Gene:

Hs.511816
genes like me logo Genes that share expression patterns with GRPEL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRPEL2 Gene

Orthologs for GRPEL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRPEL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRPEL2 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia GRPEL2 34 35
  • 90.07 (n)
cow
(Bos Taurus)
Mammalia GRPEL2 34 35
  • 88.99 (n)
rat
(Rattus norvegicus)
Mammalia Grpel2 34
  • 86.31 (n)
mouse
(Mus musculus)
Mammalia Grpel2 34 16 35
  • 85.27 (n)
oppossum
(Monodelphis domestica)
Mammalia GRPEL2 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRPEL2 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRPEL2 34 35
  • 69.47 (n)
lizard
(Anolis carolinensis)
Reptilia GRPEL2 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grpel2 34
  • 61.88 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100004941 34
  • 57.98 (n)
grpel2 35
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Roe1 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34C12.8 35
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGE1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6300 35
  • 31 (a)
OneToMany
Species where no ortholog for GRPEL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRPEL2 Gene

ENSEMBL:
Gene Tree for GRPEL2 (if available)
TreeFam:
Gene Tree for GRPEL2 (if available)

Paralogs for GRPEL2 Gene

Paralogs for GRPEL2 Gene

(2) SIMAP similar genes for GRPEL2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GRPEL2 Gene

genes like me logo Genes that share paralogs with GRPEL2: view

Variants for GRPEL2 Gene

Sequence variations from dbSNP and Humsavar for GRPEL2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10477416 -- 149,354,902(+) AATGG(C/T)GCGAT intron-variant, downstream-variant-500B
rs111608650 -- 149,344,301(+) GAAGC(A/G)GAACT upstream-variant-2KB
rs112009937 -- 149,346,139(+) GTGGT(G/T)CTTTT intron-variant
rs112397354 -- 149,345,413(+) GCAAC(C/T)GGAAG upstream-variant-2KB
rs113132727 -- 149,348,995(+) CATAC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRPEL2 Gene

Variant ID Type Subtype PubMed ID
esv3607137 CNV gain 21293372
nsv599948 CNV loss 21841781

Variation tolerance for GRPEL2 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRPEL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRPEL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRPEL2 Gene

Disorders for GRPEL2 Gene

Relevant External Links for GRPEL2

Genetic Association Database (GAD)
GRPEL2
Human Genome Epidemiology (HuGE) Navigator
GRPEL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRPEL2

No disorders were found for GRPEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRPEL2 Gene

Publications for GRPEL2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. (PMID: 9694873) Naylor D.J. … j P.B. (J. Biol. Chem. 1998) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for GRPEL2 Gene

Sources for GRPEL2 Gene

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