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Aliases for GRPEL1 Gene

Aliases for GRPEL1 Gene

  • GrpE-Like 1, Mitochondrial (E. Coli) 2 3
  • HMGE 3 4 6
  • Mt-GrpE#1 3 4
  • GrpE Protein Homolog 1, Mitochondrial 3
  • GrpE-Like Protein Cochaperone 3
  • GREPEL1 4

External Ids for GRPEL1 Gene

Summaries for GRPEL1 Gene

GeneCards Summary for GRPEL1 Gene

GRPEL1 (GrpE-Like 1, Mitochondrial (E. Coli)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include protein homodimerization activity and chaperone binding. An important paralog of this gene is GRPEL2.

UniProtKB/Swiss-Prot for GRPEL1 Gene

  • Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRPEL1 Gene

Genomics for GRPEL1 Gene

Genomic Location for GRPEL1 Gene

Start:
7,058,906 bp from pter
End:
7,068,197 bp from pter
Size:
9,292 bases
Orientation:
Minus strand

Genomic View for GRPEL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRPEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRPEL1 Gene

Regulatory Elements for GRPEL1 Gene

Proteins for GRPEL1 Gene

  • Protein details for GRPEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAV7-GRPE1_HUMAN
    Recommended name:
    GrpE protein homolog 1, mitochondrial
    Protein Accession:
    Q9HAV7
    Secondary Accessions:
    • B2R783
    • Q549M6

    Protein attributes for GRPEL1 Gene

    Size:
    217 amino acids
    Molecular mass:
    24279 Da
    Quaternary structure:
    • Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Binds to HSP70, HSC70 and HSJ1B.

neXtProt entry for GRPEL1 Gene

Proteomics data for GRPEL1 Gene at MOPED

Post-translational modifications for GRPEL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRPEL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GRPEL1 Gene

Domains for GRPEL1 Gene

Protein Domains for GRPEL1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

GRPE1_HUMAN
Family:
  • Belongs to the GrpE family.:
    • Q9HAV7
genes like me logo Genes that share domains with GRPEL1: view

No data available for Gene Families for GRPEL1 Gene

Function for GRPEL1 Gene

Molecular function for GRPEL1 Gene

UniProtKB/Swiss-Prot Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins

Gene Ontology (GO) - Molecular Function for GRPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0051082 unfolded protein binding IDA 11311562
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with GRPEL1: view

miRNA for GRPEL1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GRPEL1 Gene

Localization for GRPEL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRPEL1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRPEL1 Gene COMPARTMENTS Subcellular localization image for GRPEL1 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for GRPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix IDA 11311562
genes like me logo Genes that share ontologies with GRPEL1: view

Pathways for GRPEL1 Gene

genes like me logo Genes that share pathways with GRPEL1: view

Pathways by source for GRPEL1 Gene

2 Reactome pathways for GRPEL1 Gene

Gene Ontology (GO) - Biological Process for GRPEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006626 protein targeting to mitochondrion TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with GRPEL1: view

Transcripts for GRPEL1 Gene

mRNA/cDNA for GRPEL1 Gene

Unigene Clusters for GRPEL1 Gene

GrpE-like 1, mitochondrial (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRPEL1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for GRPEL1 Gene

GeneLoc Exon Structure for
GRPEL1
ECgene alternative splicing isoforms for
GRPEL1

Expression for GRPEL1 Gene

mRNA expression in normal human tissues for GRPEL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRPEL1 Gene

SOURCE GeneReport for Unigene cluster for GRPEL1 Gene Hs.443723

genes like me logo Genes that share expressions with GRPEL1: view

Orthologs for GRPEL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRPEL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRPEL1 36
  • 99.54 (n)
  • 100 (a)
GRPEL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRPEL1 36
  • 85.1 (n)
  • 89.86 (a)
GRPEL1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRPEL1 36
  • 86.27 (n)
  • 91.2 (a)
GRPEL1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grpel1 36
  • 83.72 (n)
  • 88.02 (a)
Grpel1 16
Grpel1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 86 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GRPEL1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grpel1 36
  • 84.02 (n)
  • 88.48 (a)
chicken
(Gallus gallus)
Aves GRPEL1 36
  • 74.11 (n)
  • 82.33 (a)
GRPEL1 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRPEL1 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23742 36
tropical clawed frog
(Silurana tropicalis)
Amphibia grpel1 36
  • 71.77 (n)
  • 73.21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12646 36
zebrafish
(Danio rerio)
Actinopterygii Dr.5829 36
grpel1 36
  • 66.35 (n)
  • 73.24 (a)
grpel1 37
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011150 36
  • 59.83 (n)
  • 58.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Roe1 36
  • 54.8 (n)
  • 49.27 (a)
Roe1 37
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34C12.8 36
  • 51.65 (n)
  • 43.83 (a)
C34C12.8 37
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGE1 36
  • 48.77 (n)
  • 41.61 (a)
MGE1 37
  • 30 (a)
OneToMany
MGE1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07326g 36
  • 48.19 (n)
  • 39.43 (a)
rice
(Oryza sativa)
Liliopsida Os08g0338700 36
  • 53.06 (n)
  • 45.58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01516 36
  • 48.84 (n)
  • 43.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mge1 36
  • 47.27 (n)
  • 39.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6300 37
  • 39 (a)
OneToMany
Species with no ortholog for GRPEL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRPEL1 Gene

ENSEMBL:
Gene Tree for GRPEL1 (if available)
TreeFam:
Gene Tree for GRPEL1 (if available)

Paralogs for GRPEL1 Gene

Paralogs for GRPEL1 Gene

Selected SIMAP similar genes for GRPEL1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for GRPEL1 Gene

genes like me logo Genes that share paralogs with GRPEL1: view

Variants for GRPEL1 Gene

Sequence variations from dbSNP and Humsavar for GRPEL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1056569 -- 7,061,143(-) AGTGT(G/T)TTCCA reference, missense
rs2276968 -- 7,068,391(-) AAACC(A/C)GGCTC upstream-variant-2KB
rs2276969 -- 7,067,879(-) CCCGG(C/T)CTCGG intron-variant
rs2358718 -- 7,067,016(+) GTGTT(G/T)TTAAG intron-variant
rs2359011 -- 7,064,325(+) TTTAC(G/T)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRPEL1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
esv34033 CNV Loss 18971310
dgv1568e1 CNV Complex 17122850
nsv428436 CNV Gain 18775914
nsv469847 CNV Complex 16826518
nsv878531 CNV Loss 21882294
nsv878533 CNV Loss 21882294
nsv4217 CNV Loss 18451855

Relevant External Links for GRPEL1 Gene

HapMap Linkage Disequilibrium report
GRPEL1
Human Gene Mutation Database (HGMD)
GRPEL1

Disorders for GRPEL1 Gene

Relevant External Links for GRPEL1

Genetic Association Database (GAD)
GRPEL1
Human Genome Epidemiology (HuGE) Navigator
GRPEL1
genes like me logo Genes that share disorders with GRPEL1: view

No data available for UniProtKB/Swiss-Prot for GRPEL1 Gene

Publications for GRPEL1 Gene

  1. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. (PMID: 11311562) Choglay A.A. … Cheetham M.E. (Gene 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PMID: 21642987) Pichlmair A. … Superti-Furga G. (Nat. Immunol. 2011) 3

Products for GRPEL1 Gene

Sources for GRPEL1 Gene

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