GRPEL1 Gene
protein-coding GIFtS: 54
GCID: GC04M007060
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GrpE-like 1, mitochondrial (E. coli)
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Aliases
for GRPEL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GrpE-Like 1, Mitochondrial (E. Coli)1 2 | | GrpE-Like Protein Cochaperone2 | | HMGE1 2 3 5 | | Mt-GrpE#13 | | FLJ256091 | | GREPEL13 | | GrpE Protein Homolog 1, Mitochondrial2 | | Mt-GrpE#13 |
Export aliases for GRPEL1 gene to outside databasesPrevious GC identifers: GC04M007054 GC04M007126 GC04M007179 GC04M007061 |
Summaries
for GRPEL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: GRPE1_HUMAN, Q9HAV7Function: Essential component of the PAM complex, a complex required for the translocation of transitpeptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems tocontrol the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins
|
Genomic Views
for GRPEL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRPEL1 gene promoter:
NF-1 NF-1/L NRSF form 1 Nkx5-1 NRSF form 2 HNF-4alpha1 FOXL1 AREB6 Zic1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRPEL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRPEL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16GRPEL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M007060: view genomic region
(about GC identifiers)
Start:
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7,060,633 bp from pter |
End:
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7,069,924 bp from pter |
Size:
|
9,292 bases |
Orientation:
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minus strand |
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Proteins
for GRPEL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRPE1_HUMAN, Q9HAV7 (See
protein sequence)Recommended Name: GrpE protein homolog 1, mitochondrial precursor Size: 217 amino acids; 24279 Da
Subunit: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2,TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Binds to HSP70, HSC70 and HSJ1B
Subcellular location: Mitochondrion matrix
Secondary accessions: B2R783 Q549M6Explore the universe of human proteins at neXtProt for GRPEL1: NX_Q9HAV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HAV7
GRPEL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079472.1
ENSEMBL proteins: ENSP00000264954 Reactome Protein details: Q9HAV7
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
GRPEL1 for ontologies About GeneDecksing
GRPEL1 Antibody Products:
Assay Products for GRPEL1: |
Protein
Domains /
Families
for GRPEL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRPEL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HAV7ProtoNet protein and cluster: Q9HAV7 1 Blocks protein family: IPB000740 GrpE protein
UniProtKB/Swiss-Prot: GRPE1_HUMAN, Q9HAV7Similarity: Belongs to the GrpE family |
Function
for GRPEL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GRPE1_HUMAN, Q9HAV7Function: Essential component of the PAM complex, a complex required for the translocation of transitpeptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems tocontrol the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRPEL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRPEL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRPEL1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
GRPEL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for GRPEL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for GRPEL1
GRPEL1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRPEL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/363 Interacting proteins for GRPEL1 (Q9HAV72, 3 ENSP000002649544) via UniProtKB, MINT, STRING, and/or I2D (see all 363)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- | | GO:0006626 | protein targeting to mitochondrion |
TAS | -- | | GO:0030150 | protein import into mitochondrial matrix |
NAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
GRPEL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GRPEL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GRPEL1
Search CenterWatch for drugs/clinical trials and news about GRPEL1 / GRPE1
|
Transcripts
for GRPEL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRPEL1 gene: NM_025196.2 Unigene Cluster for GRPEL1: GrpE-like 1, mitochondrial (E. coli) Hs.443723 [show with all ESTs]Unigene Representative Sequence: AK0984754 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264954(uc003gjy.1) ENST00000504920(uc003gjz.1) ENST00000509696
ENST00000514056
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRPEL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRPEL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GRPEL1 (NM_025196) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRPEL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRPEL1 |
Additional cDNA sequence: AF070525.1 AF087896.1 AF298592.1 AK098475.1 AK301695.1 AK312882.1 BC024242.2 6 DOTS entries: DT.441631 DT.100026797 DT.95207473 DT.121229469 DT.121229408 DT.91766559 24/248 AceView cDNA sequences (see all 248): AI140924 BG176826 BG739863 BQ448478 BF430923 AF298592 AA894526 AL601647 CR601403 BU753681 NM_025196 BM912840 AI318370 BM662604 BP342386 BC024242 CK724917 BI838148 CR621363 CD369744 BU543304 AI492768 T51856 AL542571
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for GRPEL1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
|---|
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| SP1: | | | | | - | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for GRPEL1
|
Expression
for GRPEL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRPEL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGACTGGC
About this image
See GRPEL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRPEL1
SOURCE GeneReport for Unigene cluster: Hs.443723
SABiosciences Expression via Pathway-Focused PCR Array including GRPEL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRPEL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRPEL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRPEL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRPEL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRPEL1 |
Orthologs
for GRPEL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for GRPEL1 gene from 10/38 species (see all 38) About this table
ENSEMBL Gene Tree for GRPEL1 (if available)
TreeFam Gene Tree for GRPEL1 (if available) |
Paralogs
for GRPEL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRPEL1 gene
- GRPEL22
2 SIMAP similar genes for GRPEL1 using alignment to 1 protein entry: GRPE1_HUMAN:GRPEL2 DKFZp451C205
GRPEL1 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for GRPEL1
PGOHUM00000232845 PGOHUM00000232886 PGOHUM00000233395 PGOHUM00000263255
|
Genomic Variants
for GRPEL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for GRPEL1
2 CNVs: 3478 47919 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRPEL1 |
|
Disorders
/ Diseases
for GRPEL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRPEL1 for disorders About GeneDecksing
OMIM gene information: 606173
OMIM disorders: --
2  diseases for GRPEL1: About MalaCardspneumonia malaria
Human Genome Epidemiology (HuGE) Navigator: GRPEL1 (1 document)
Export disorders for GRPEL1 gene to outside databases
|
Publications
for GRPEL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRPEL1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with GRPEL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. (PubMed id 11311562)1, 2, 3 Choglay A.A.... Cheetham M.E. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Identification of intracellular proteins associated w ith the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-I CR mass spectrometry. (PubMed id 18457437)1 Forsman A....Rymo L. (2008)
|
External Searches for GRPEL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRPEL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRPEL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRPEL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRPEL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GRPEL1 gene:
Search GeneIP for patents involving GRPEL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRPEL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for GRPEL1 | | OriGene Custom Protein Services for GRPEL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRPEL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRPEL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRPEL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRPEL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRPEL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRPEL1 |
| |
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| |  |  |  |  | | | | | | Recombinant Protein for GRPEL1 |
|
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 | | | GRPEL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRPEL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for GRPEL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRPEL1 |
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