Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GRPEL1 Gene

protein-coding   GIFtS: 58
GCID: GC04M007060

GrpE-Like 1, Mitochondrial (E. Coli)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
GrpE-Like 1, Mitochondrial (E. Coli)1 2     mt-GrpE#12
HMGE2 3 5     GREPEL13
GrpE Protein Homolog 1, Mitochondrial2     Mt-GrpE#13
GrpE-Like Protein Cochaperone2     

External Ids:    HGNC: 196961   Entrez Gene: 802732   Ensembl: ENSG000001095197   OMIM: 6061735   UniProtKB: Q9HAV73   

Export aliases for GRPEL1 gene to outside databases

Previous GC identifers: GC04M007054 GC04M007126 GC04M007179 GC04M007061


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for GRPEL1 Gene:
GRPEL1 (GrpE-like 1, mitochondrial (E. coli)) is a protein-coding gene. GO annotations related to this gene include chaperone binding and protein homodimerization activity. An important paralog of this gene is GRPEL2.

UniProtKB/Swiss-Prot: GRPE1_HUMAN, Q9HAV7
Function: Essential component of the PAM complex, a complex required for the translocation of transit
peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRPEL1 gene promoter:
         NF-1   NF-1/L   NRSF form 1   Nkx5-1   NRSF form 2   HNF-4alpha1   FOXL1   AREB6   Zic1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRPEL1 promoter sequence
   Search Chromatin IP Primers for GRPEL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRPEL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16

GRPEL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRPEL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M007060:  view genomic region     (about GC identifiers)

Start:
7,060,633 bp from pter      End:
7,069,924 bp from pter
Size:
9,292 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GRPE1_HUMAN, Q9HAV7 (See protein sequence)
Recommended Name: GrpE protein homolog 1, mitochondrial precursor  
Size: 217 amino acids; 24279 Da
Subunit: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or
GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Binds to HSP70, HSC70 and HSJ1B
Secondary accessions: B2R783 Q549M6

Explore the universe of human proteins at neXtProt for GRPEL1: NX_Q9HAV7

Explore proteomics data for GRPEL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See GRPEL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079472.1  
    ENSEMBL proteins: 
     ENSP00000264954  
    Reactome Protein details: Q9HAV7

    GRPEL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRPEL1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRPEL1
    GenScript Custom Purified and Recombinant Proteins Services for GRPEL1
    Novus Biologicals GRPEL1 Proteins
    Novus Biologicals GRPEL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for GRPEL1
    Cloud-Clone Corp. Proteins for GRPEL1

     
    Search eBioscience for Proteins for GRPEL1 

     
    antibodies-online proteins for GRPEL1 (10 products) 

     
    antibodies-online peptides for GRPEL1

    GRPEL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GRPEL1
    Novus Biologicals GRPEL1 Antibodies
    Abcam antibodies for GRPEL1
    Cloud-Clone Corp. Antibodies for GRPEL1
    Search ThermoFisher Antibodies for GRPEL1
    antibodies-online antibodies for GRPEL1 (18 products) 

    GRPEL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRPEL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRPEL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRPEL1
    Cloud-Clone Corp. CLIAs for GRPEL1
    Search eBioscience for ELISAs for GRPEL1 
    antibodies-online kits for GRPEL1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR009012 GrpE_head
     IPR013805 GrpE_coiled_coil
     IPR000740 GrpE

    Graphical View of Domain Structure for InterPro Entry Q9HAV7

    ProtoNet protein and cluster: Q9HAV7

    1 Blocks protein domain: IPB000740 GrpE protein

    UniProtKB/Swiss-Prot: GRPE1_HUMAN, Q9HAV7
    Similarity: Belongs to the GrpE family


    Find genes that share domains with GRPEL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRPE1_HUMAN, Q9HAV7
    Function: Essential component of the PAM complex, a complex required for the translocation of transit
    peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
    Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000774adenyl-nucleotide exchange factor activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0051082unfolded protein binding IDA11311562
    GO:0051087chaperone binding IEA--
         
    Find genes that share ontologies with GRPEL1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GRPEL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRPEL1:
    hsa-mir-155-5p (MIRT020623), hsa-mir-484 (MIRT042368), hsa-mir-98-5p (MIRT027433), hsa-mir-652-3p (MIRT039522)

    Block miRNA regulation of human, mouse, rat GRPEL1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GRPEL1:
    hsa-miR-877* hsa-miR-3158-3p hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidGRPEL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRPEL1
    Predesigned siRNA for gene silencing in human, mouse, rat GRPEL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRPEL1

    Clone
    Products:
         
    OriGene clones in human, mouse for GRPEL1 (see all 6)
    OriGene ORF clones in mouse, rat for GRPEL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRPEL1 (NM_025196)
    Sino Biological Human cDNA Clone for GRPEL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRPEL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRPEL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRPEL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRPEL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRPEL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GRPE1_HUMAN, Q9HAV7: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix IDA11311562

    Find genes that share ontologies with GRPEL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GRPEL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import


    Find genes that share SuperPaths with GRPEL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for GRPEL1
        Mitochondrial protein import


        Pathway & Disease-focused RT2 Profiler PCR Array including GRPEL1: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GRPEL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRPEL1 (Q9HAV72, 3 ENSP000002649544) via UniProtKB, MINT, STRING, and/or I2D (see all 403)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0030150protein import into mitochondrial matrix ----
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with GRPEL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GRPEL1 (GRPE1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GRPEL1 gene: 
    NM_025196.2  

    Unigene Cluster for GRPEL1:

    GrpE-like 1, mitochondrial (E. coli)
    Hs.443723  [show with all ESTs]
    Unigene Representative Sequence: AK098475
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264954(uc003gjy.1) ENST00000504920(uc003gjz.1) ENST00000509696
    ENST00000514056
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GRPEL1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate GRPEL1:
    hsa-miR-877* hsa-miR-3158-3p hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidGRPEL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GRPEL1
    Predesigned siRNA for gene silencing in human, mouse, rat GRPEL1
    Clone
    Products:
         
    OriGene clones in human, mouse for GRPEL1 (see all 6)
    OriGene ORF clones in mouse, rat for GRPEL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRPEL1 (NM_025196)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRPEL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRPEL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRPEL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRPEL1
      QuantiTect SYBR Green Assays in human, mouse, rat GRPEL1
      QuantiFast Probe-based Assays in human, mouse, rat GRPEL1

    Additional mRNA sequence: 

    AF070525.1 AF087896.1 AF298592.1 AK098475.1 AK301695.1 AK312882.1 BC024242.2 

    6 DOTS entries:

    DT.441631  DT.100026797  DT.95207473  DT.121229469  DT.121229408  DT.91766559 

    Selected AceView cDNA sequences (see all 248):

    CB160588 CB305906 AL601647 AI318370 AA989480 BM665927 BI826823 AA251912 
    BM662604 AL050191 AI340183 CD559208 AI492768 BG739863 AA894526 CR622705 
    AI284063 CD672043 F02140 CD672042 AI140924 BI964173 CR621363 CD369744 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GRPEL1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:              -     -                 -                     
    SP2:              -     -                                       
    SP3:                                      -                     
    SP4:                                      -                     


    ECgene alternative splicing isoforms for GRPEL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GRPEL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGACTGGC
    GRPEL1 Expression
    About this image

    GRPEL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRPEL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443723
        Pathway & Disease-focused RT2 Profiler PCR Array including GRPEL1: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GRPEL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRPEL1
    QuantiTect SYBR Green Assays in human, mouse, rat GRPEL1
    QuantiFast Probe-based Assays in human, mouse, rat GRPEL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRPEL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GRPEL1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grpel11 , 5 GrpE-like 1, mitochondrial1, 5 83.72(n)1
    88.02(a)1
      5 (19.14 cM)5
    177131  NM_024478.21  NP_077798.11 
     364649985 
    chicken
    (Gallus gallus)
    Aves GRPEL11 GrpE-like 1, mitochondrial (E. coli) 74.11(n)
    82.33(a)
      422865  NM_001006458.1  NP_001006458.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRPEL16
    GrpE-like 1, mitochondrial (E. coli)
    69(a)
    1 ↔ 1
    4(79482381-79487448)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237422 Xenopus laevis transcribed sequence with weak similarity more 77.88(n)    BG555876.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.58292 Transcribed sequence with moderate similarity to protein more 76.13(n)    57058925 
    fruit fly
    (Drosophila melanogaster)
    Insecta Roe11 Roe1 54.8(n)
    49.27(a)
      36508  NM_137042.3  NP_610886.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C34C12.81 C34C12.8 51.65(n)
    43.83(a)
      175449  NM_065312.4  NP_497713.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MGE1(YOR232W)4
    MGE11
    Mitochondrial matrix cochaperone, acts as a nucleotide more4
    MGE11
    48.77(n)1
    41.61(a)1
      15(774573-775259)4
    8544071, 4  NP_014875.31  NP_014875.14 
    rice
    (Oryza sativa)
    Liliopsida Os08g03387001 Os08g0338700 53.06(n)
    45.58(a)
      4345316  NM_001068121.1  NP_001061586.1 


    ENSEMBL Gene Tree for GRPEL1 (if available)
    TreeFam Gene Tree for GRPEL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GRPEL1 gene
    GRPEL22  
    2 SIMAP similar genes for GRPEL1 using alignment to 1 protein entry:     GRPE1_HUMAN:
    GRPEL2    DKFZp451C205

    Find genes that share paralogs with GRPEL1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for GRPEL1
    PGOHUM00000232845 PGOHUM00000232886 PGOHUM00000233395 PGOHUM00000263255


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GRPEL1 (see all 319)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399290881,2
    C--7061304(+) TATCCA/C/GAAGAT 1 -- int10--------
    rs37969081,2
    C,F,A,H--7061378(+) TTCCTA/GTGCAG 1 -- int134Minor allele frequency- G:0.31EA NA NS WA CSA 4587
    rs778901591,2
    C,F--7061484(+) TCTAAG/ACCCTG 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1866452131,2
    --7061517(+) AGCCCC/TTTGGC 1 -- int10--------
    rs1917661291,2
    --7061653(+) TGTACA/GTGAAT 1 -- int10--------
    rs1506520971,2
    --7061666(+) GCACGC/TACGCA 1 -- int10--------
    rs789965781,2
    C,F--7061737(+) CTCAGC/TGGCAA 1 -- int11Minor allele frequency- T:0.13WA 118
    rs773996831,2
    C--7061752(+) CTCCAT/CGAGAG 1 -- int12Minor allele frequency- C:0.06CSA WA 119
    rs131112811,2
    C,F--7061781(+) GAAAGT/CAGGAA 1 -- ut31 ese33Minor allele frequency- C:0.33NA 6
    rs1396910861,2
    --7061925(+) ACTAGC/TTGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GRPEL1 (7060633 - 7069924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GRPEL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4217CNV Loss18451855
    esv34033CNV Loss18971310
    nsv878533CNV Loss21882294
    nsv878531CNV Loss21882294
    nsv428436CNV Gain18775914
    nsv469847CNV Complex16826518
    dgv1568e1CNV Complex17122850
    esv34196OTHER Inversion12058347

    Human Gene Mutation Database (HGMD): GRPEL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRPEL1
    DNA2.0 Custom Variant and Variant Library Synthesis for GRPEL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606173    OMIM disorders: --


    Find genes that share disorders with GRPEL1           About GenesLikeMe

    Genetic Association Database (GAD): GRPEL1
    Human Genome Epidemiology (HuGE) Navigator: GRPEL1 (1 document)

    Export disorders for GRPEL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GRPEL1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with GRPEL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. (PubMed id 11311562)1, 2, 3 Choglay A.A.... Cheetham M.E. (Gene 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function. (PubMed id 23345595)1 Marada A....Sepuri N.B. (Mol. Biol. Cell 2013)
    5. PKCI/ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PubMed id 22304920)1 Lau E....Ronai Z.A. (Cell 2012)
    6. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80273 HGNC: 19696 AceView: GRPEL1 Ensembl:ENSG00000109519 euGenes: HUgn80273
    ECgene: GRPEL1 H-InvDB: GRPEL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GRPEL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GRPEL1 gene:
    Search GeneIP for patents involving GRPEL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GRPEL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GRPEL1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GRPEL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRPEL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GRPEL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRPEL1   OriGene Custom Protein Services for GRPEL1  

     
     
     Block miRNA regulation of human, mouse, rat GRPEL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GRPEL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRPEL1 Predesigned siRNA for gene silencing in human, mouse, rat GRPEL1
     QuantiFast Probe-based Assays in human, mouse, rat GRPEL1 QuantiTect SYBR Green Assays in human, mouse, rat GRPEL1
     PCR Arrays including human, mouse, rat GRPEL1 Search Chromatin IP Primers for GRPEL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRPEL1  Search GeneGlobe Interaction Network for GRPEL1
     Regulatory tfbs in GRPEL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GRPEL1 GenScript cDNA clones with any tag delivered in your preferred vector for GRPEL1
     GenScript Custom Assay Services for GRPEL1 GenScript Custom overexpressing Cell Line Services for GRPEL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for GRPEL1 (GRPE1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for GRPEL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GRPEL1 antibodies
     GRPEL1 proteins
     GRPEL1 lysates
     Antibodies for GRPEL1
     See all of Abcam's Antibodies, Kits and Proteins for GRPEL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GRPEL1
     Proteins for GRPEL1
     Antibodies for GRPEL1
     ELISAs for GRPEL1
     CLIAs for GRPEL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for GRPEL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRPEL1
     SwitchGear 3'UTR luciferase reporter plasmids for GRPEL1
     SwitchGear Promoter luciferase reporter plasmids for GRPEL1
     Search ThermoFisher Antibodies for GRPEL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRPEL1
     Browse compounds at ApexBio
     Search Addgene for plasmids for GRPEL1
      Search eBioscience for proteins for GRPEL1
      Search eBioscience for elisas for GRPEL1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for GRPEL1
     antibodies-online antibodies for GRPEL1 (18 products)
     antibodies-online kits for GRPEL1 (4 products)
     antibodies-online peptides for GRPEL1
     antibodies-online proteins for GRPEL1 (10 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRPEL1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4