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Aliases for GRP Gene

Aliases for GRP Gene

  • Gastrin Releasing Peptide 2 3 5
  • Gastrin-Releasing Peptide 2 3
  • Neuromedin C 2 3
  • Prepro-GRP 2 3
  • Bombesin 2 3
  • Pre-Progastrin Releasing Peptide 3
  • Testicular Tissue Protein Li 103 3
  • PreproGRP 3
  • GRP-10 3
  • ProGRP 3
  • BN 3

External Ids for GRP Gene

Previous GeneCards Identifiers for GRP Gene

  • GC18P056719
  • GC18P056861
  • GC18P055036
  • GC18P055038
  • GC18P053595

Summaries for GRP Gene

Entrez Gene Summary for GRP Gene

  • This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for GRP Gene

GRP (Gastrin Releasing Peptide) is a Protein Coding gene. Diseases associated with GRP include Duodenal Ulcer and Lung Cancer. Among its related pathways are Peptide ligand-binding receptors and Incretin synthesis, secretion, and inactivation. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for GRP Gene

  • GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity).

Tocris Summary for GRP Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for GRP Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRP Gene

Genomics for GRP Gene

Regulatory Elements for GRP Gene

Enhancers for GRP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G059138 1.1 ENCODE 10.6 -77.8 -77826 4.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 SEC11C ZNF532 GRP LOC100286992
GH18G059155 0.6 ENCODE 11 -63.7 -63735 0.2 JUND BHLHE40 SIN3A FOS MAFK NFE2L2 GRP LOC100286992 SEC11C
GH18G059724 0.2 dbSUPER 6.6 +506.3 506252 1.0 CCBE1 GRP ENSG00000273664 GC18P059755
GH18G059249 0.6 ENCODE 0.3 +30.2 30246 0.2 CTCF ZNF654 CEBPB REST CEBPG RAD21 MAFF ZNF316 SMC3 MAFK GC18M059272 GRP
GH18G059232 0.4 ENCODE 0.4 +13.4 13416 0.1 ZNF316 MAFK GRP GC18M059272
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRP on UCSC Golden Path with GeneCards custom track

Genomic Location for GRP Gene

Chromosome:
18
Start:
59,219,118 bp from pter
End:
59,230,774 bp from pter
Size:
11,657 bases
Orientation:
Plus strand

Genomic View for GRP Gene

Genes around GRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRP Gene

Proteins for GRP Gene

  • Protein details for GRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07492-GRP_HUMAN
    Recommended name:
    Gastrin-releasing peptide
    Protein Accession:
    P07492
    Secondary Accessions:
    • P07491
    • P81553
    • Q14454
    • Q53YA0
    • Q9BSY7

    Protein attributes for GRP Gene

    Size:
    148 amino acids
    Molecular mass:
    16213 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA52612.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRP Gene

    Alternative splice isoforms for GRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRP Gene

Post-translational modifications for GRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GRP

Assay Products

  • Cloud-Clone Corp Assay Kits for GRP

No data available for DME Specific Peptides for GRP Gene

Domains & Families for GRP Gene

Gene Families for GRP Gene

Protein Domains for GRP Gene

Suggested Antigen Peptide Sequences for GRP Gene

Graphical View of Domain Structure for InterPro Entry

P07492

UniProtKB/Swiss-Prot:

GRP_HUMAN :
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
Family:
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
genes like me logo Genes that share domains with GRP: view

Function for GRP Gene

Molecular function for GRP Gene

UniProtKB/Swiss-Prot Function:
GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity).

Gene Ontology (GO) - Molecular Function for GRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding NAS 3027901
GO:0005184 neuropeptide hormone activity IDA 8756537
genes like me logo Genes that share ontologies with GRP: view
genes like me logo Genes that share phenotypes with GRP: view

Animal Models for GRP Gene

MGI Knock Outs for GRP:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRP

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GRP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GRP Gene

Localization for GRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRP gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 3211139
GO:0034774 secretory granule lumen ISS --
genes like me logo Genes that share ontologies with GRP: view

Pathways & Interactions for GRP Gene

genes like me logo Genes that share pathways with GRP: view

SIGNOR curated interactions for GRP Gene

Activates:

Gene Ontology (GO) - Biological Process for GRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 3027901
GO:0007218 neuropeptide signaling pathway IDA 8756537
GO:0035176 social behavior IEA --
GO:0036343 psychomotor behavior IEA --
GO:0043207 response to external biotic stimulus IEA --
genes like me logo Genes that share ontologies with GRP: view

Drugs & Compounds for GRP Gene

(80) Drugs for GRP Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GRP (porcine) Pharma Endogenous GRP receptor agonist 0
Bombesin Pharma Full agonist, Agonist Involved in gastrointestinal tract function 9
GRP (human) Pharma Endogenous GRP receptor agonist 0
Neuromedin B (porcine) Pharma Mammalian bombesin-like peptide 0
PD 176252 Pharma Antagonist GRP (BB2) and NMB (BB1) receptor antagonist 0

(64) Additional Compounds for GRP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GRP Gene

Compound Action Cas Number
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9
Neuromedin B (porcine) Mammalian bombesin-like peptide 87096-84-2
PD 176252 GRP (BB2) and NMB (BB1) receptor antagonist 204067-01-6

(1) ApexBio Compounds for GRP Gene

Compound Action Cas Number
GRP (porcine) 74815-57-9
genes like me logo Genes that share compounds with GRP: view

Drug Products

Transcripts for GRP Gene

Unigene Clusters for GRP Gene

Gastrin-releasing peptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GRP

Alternative Splicing Database (ASD) splice patterns (SP) for GRP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for GRP Gene

GeneLoc Exon Structure for
GRP
ECgene alternative splicing isoforms for
GRP

Expression for GRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRP Gene

This gene is overexpressed in Brain - Hippocampus (x7.3), Stomach (x6.8), and Brain - Substantia nigra (x5.6).

Protein differential expression in normal tissues from HIPED for GRP Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRP Gene



Protein tissue co-expression partners for GRP Gene

NURSA nuclear receptor signaling pathways regulating expression of GRP Gene:

GRP

SOURCE GeneReport for Unigene cluster for GRP Gene:

Hs.153444

Evidence on tissue expression from TISSUES for GRP Gene

  • Lung(4.5)
  • Nervous system(3.8)
  • Pancreas(3.3)
  • Stomach(3.2)
  • Intestine(2.8)
  • Blood(2.2)
  • Gall bladder(2.1)
  • Muscle(2.1)
  • Skin(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with GRP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRP Gene

Orthologs for GRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRP 34 35
  • 99.76 (n)
rat
(Rattus norvegicus)
Mammalia Grp 34
  • 80.43 (n)
mouse
(Mus musculus)
Mammalia Grp 34 16 35
  • 78.35 (n)
cow
(Bos Taurus)
Mammalia GRP 35
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRP 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRP 35
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRP 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRP 34 35
  • 63.31 (n)
Species where no ortholog for GRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GRP Gene

ENSEMBL:
Gene Tree for GRP (if available)
TreeFam:
Gene Tree for GRP (if available)

Paralogs for GRP Gene

No data available for Paralogs for GRP Gene

Variants for GRP Gene

Sequence variations from dbSNP and Humsavar for GRP Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000061458 -- 59,218,959(+) AGGAG(A/G)AATAG upstream-variant-2KB
rs1000209299 -- 59,231,067(+) AATAG(C/T)CCTTT downstream-variant-500B
rs1000413706 -- 59,225,232(+) ACCTA(A/G/T)CTAGT intron-variant
rs1000657195 -- 59,222,590(+) ATGTT(A/T)CACTT intron-variant, upstream-variant-2KB
rs1001015781 -- 59,226,859(+) AGCCT(C/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRP Gene

Variant ID Type Subtype PubMed ID
nsv1065588 CNV gain 25217958
nsv1144836 CNV deletion 24896259

Variation tolerance for GRP Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRP Gene

Disorders for GRP Gene

MalaCards: The human disease database

(25) MalaCards diseases for GRP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duodenal ulcer
  • curling ulcer
lung cancer
  • lung cancer, protection against
neuroendocrine tumor
  • neuroendocrine neoplasm
zollinger-ellison syndrome
  • gastrinoma
small cell cancer of the lung, somatic
  • small cell cancer of the lung
- elite association - COSMIC cancer census association via MalaCards
Search GRP in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRP

Genetic Association Database (GAD)
GRP
Human Genome Epidemiology (HuGE) Navigator
GRP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRP
genes like me logo Genes that share disorders with GRP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRP Gene

Publications for GRP Gene

  1. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  2. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PMID: 18452185) Hodges L.M. … Hamilton S.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
  4. Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. (PMID: 16909108) Corral R.S. … Fresno M. (Oncogene 2007) 3 22 64
  5. Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. (PMID: 15750618) MartA-nez A. … Cuttitta F. (Oncogene 2005) 3 22 64

Products for GRP Gene

  • Addgene plasmids for GRP

Sources for GRP Gene

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