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GRP Gene

protein-coding   GIFtS: 59
GCID: GC18P056861

Gastrin-Releasing Peptide

  See GRP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Gastrin-Releasing Peptide1 2     GRP-102
bombesin1 2     Pre-Progastrin Releasing Peptide2
Neuromedin C1 2     preproGRP2
prepro-GRP1 2     proGRP2
BN2     

External Ids:    HGNC: 46051   Entrez Gene: 29222   Ensembl: ENSG000001344437   OMIM: 1372605   UniProtKB: P074923   

Export aliases for GRP gene to outside databases

Previous GC identifers: GC18P056719 GC18P055036 GC18P055038 GC18P053595


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRP Gene:
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following
cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the
10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central
nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial
cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach,
pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRP Gene:
GRP (gastrin-releasing peptide) is a protein-coding gene. Diseases associated with GRP include diffuse pulmonary fibrosis, and anencephaly. GO annotations related to this gene include neuropeptide hormone activity and receptor binding.

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492
Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative
feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term
potentiation, and amygdala-dependent memory for fear (By similarity)

summary for GRP Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor).

Gene Wiki entry for GRP (Gastrin-releasing peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRP gene promoter:
         CREB   PPAR-gamma1   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRP promoter sequence
   Search Chromatin IP Primers for GRP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1-q21.32   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.1-q21.32

GRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRP gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P056861:  view genomic region     (about GC identifiers)

Start:
56,887,400 bp from pter      End:
56,898,006 bp from pter
Size:
10,607 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GRP_HUMAN, P07492 (See protein sequence)
Recommended Name: Gastrin-releasing peptide precursor  
Size: 148 amino acids; 16213 Da
Sequence caution: Sequence=AAA52612.1; Type=Erroneous gene model prediction;
Secondary accessions: P07491 P81553 Q14454 Q53YA0 Q9BSY7
Alternative splicing: 3 isoforms:  P07492-1   P07492-2   P07492-3   

Explore the universe of human proteins at neXtProt for GRP: NX_P07492

Explore proteomics data for GRP at MOPED


See GRP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001012530.1  NP_001012531.1  NP_002082.2  

ENSEMBL proteins: 
 ENSP00000256857   ENSP00000434101   ENSP00000389696   ENSP00000397814   ENSP00000431579  
Reactome Protein details: P07492

GRP Human Recombinant Protein Products:

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Novus Biologicals GRP Protein
Novus Biologicals GRP Lysate
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Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for GRP

 
Search eBioscience for Proteins for GRP 

 
antibodies-online proteins for GRP (5 products) 

 
antibodies-online peptides for GRP

GRP Antibody Products:

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Novus Biologicals GRP Antibodies
Abcam antibodies for GRP (Q3ZCW2, P07492)
Cloud-Clone Corp. Antibodies for GRP
ThermoFisher Antibodies for GRP
antibodies-online antibodies for GRP (62 products) 

GRP Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for GRP
R&D Systems ELISAs for GRP (Gastrin-releasing Peptide/Bombesin)
GenScript Custom Assay Services for GRP
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for GRP
Cloud-Clone Corp. CLIAs for GRP
Search eBioscience for ELISAs for GRP 
antibodies-online kits for GRP (24 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR015674 Gastrin-RP
 IPR000874 Bombesin

Graphical View of Domain Structure for InterPro Entry P07492

ProtoNet protein and cluster: P07492

1 Blocks protein domain: IPB000874 Bombesin-like peptide

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492
Similarity: Belongs to the bombesin/neuromedin-B/ranatensin family


Find genes that share domains with GRP           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: GRP_HUMAN, P07492
Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative
feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term
potentiation, and amygdala-dependent memory for fear (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding NAS3027901
GO:0005184neuropeptide hormone activity IDA8756537
     
Find genes that share ontologies with GRP           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for GRP

miRNA
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Block miRNA regulation of human, mouse, rat GRP using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate GRP:
hsa-miR-1257 hsa-miR-7 hsa-miR-507
SwitchGear 3'UTR luciferase reporter plasmidGRP 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for GRP
Predesigned siRNA for gene silencing in human, mouse, rat GRP

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for GRP

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OriGene clones in human, mouse for GRP (see all 14)
OriGene ORF clones in mouse, rat for GRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GRP (NM_001138)
Sino Biological Human cDNA Clone for GRP
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRP
Addgene plasmids for GRP 

Cell Line
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GenScript Custom overexpressing Cell Line Services for GRP
Browse ESI BIO Cell Lines and PureStem Progenitors for GRP 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRP


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GRP_HUMAN, P07492: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytoskeleton2
nucleus2
plasma membrane2
cytosol1
endoplasmic reticulum1
golgi apparatus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IDA8756537

Find genes that share ontologies with GRP           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GRP About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4Incretin Synthesis, Secretion, and Inactivation
Incretin Synthesis, Secretion, and Inactivation0.88
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)0.88
5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30


Find genes that share SuperPaths with GRP           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



3 Reactome Pathways for GRP
    Peptide ligand-binding receptors
G alpha (q) signalling events
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)


    Pathway & Disease-focused RT2 Profiler PCR Arrays including GRP: 
          Angiogenic Growth Factors in human mouse rat
          Obesity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for GRP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for GRP (P074923 ENSP000002568574) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
InteractantInteraction Details
GeneCardExternal ID(s)
DPP4P274873, ENSP000003537314I2D: score=1 STRING: ENSP00000353731
NCLP193383, ENSP000003181954I2D: score=1 STRING: ENSP00000318195
PCBP1Q153653, ENSP000003055564I2D: score=1 STRING: ENSP00000305556
GRPRP305503, ENSP000003696434I2D: score=1 STRING: ENSP00000369643
ANKRD28O150843, ENSP000003823794I2D: score=1 STRING: ENSP00000382379
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction NAS3027901
GO:0007218neuropeptide signaling pathway IDA8756537

Find genes that share ontologies with GRP           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for GRP available from Tocris Bioscience    About this table
CompoundAction CAS #
BombesinInvolved in gastrointestinal tract function[31362-50-2]
PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
GRP (human)Endogenous GRP receptor agonist[93755-85-2]
GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

Selected Novoseek inferred chemical compound relationships for GRP gene (see all 139)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
2-pyrrolinodoxorubicin 83.5 6 11027415 (1), 16801542 (1), 16322338 (1), 11953892 (1)
phyllolitorin 78.9 20 8786559 (3), 1717141 (1), 19296643 (1), 8788416 (1)
ranatensin 78.4 11 8786559 (2), 8391296 (1), 8788416 (1)
gastrin releasing peptide 77.5 20 16464792 (5), 7910153 (2), 10470218 (2)
bw 2258u89 74.3 2 1332139 (2)
minigastrin 69.3 8 17707803 (2), 17896914 (1), 19601842 (1)
loxiglumide 67.9 19 8243522 (4), 1397878 (2), 8403798 (2), 7904286 (2) (see all 9)
diaminopropionic acid 60.6 1 15246374 (1)
8-aminooctanoic acid 59.5 1 17626788 (1)
phorbol 12,13-dibutyrate 58.7 20 8314789 (3), 8408063 (2), 12692126 (2), 2022702 (1) (see all 10)



Find genes that share compounds with GRP           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for GRP gene (3 alternative transcripts): 
NM_001012512.1  NM_001012513.1  NM_002091.3  

Unigene Cluster for GRP:

Gastrin-releasing peptide
Hs.153444  [show with all ESTs]
Unigene Representative Sequence: NM_002091
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000256857(uc002lhu.3 uc002lhv.3 uc002lhw.3) ENST00000529320
ENST00000420468 ENST00000456142 ENST00000530323
miRNA
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3 qRT-PCR Assays for microRNAs that regulate GRP:
hsa-miR-1257 hsa-miR-7 hsa-miR-507
SwitchGear 3'UTR luciferase reporter plasmidGRP 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for GRP
Predesigned siRNA for gene silencing in human, mouse, rat GRP
Clone
Products:
     
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OriGene ORF clones in mouse, rat for GRP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: GRP (NM_001138)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRP
Addgene plasmids for GRP 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for GRP
OriGene qSTAR qPCR primer pairs in human, mouse for GRP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRP
  QuantiTect SYBR Green Assays in human, mouse, rat GRP
  QuantiFast Probe-based Assays in human, mouse, rat GRP

Additional mRNA sequence: 

AB102889.1 AK307264.1 BC004488.2 BT006803.1 K02054.1 M12550.1 

3 DOTS entries:

DT.121097835  DT.444537  DT.40106111 

Selected AceView cDNA sequences (see all 54):

AI301134 BX105760 N75350 AA838825 BF110750 AI474286 AI268383 AI088154 
AI375795 NM_002091 CK903483 BC004488 BF445372 AI350288 AI675366 AA456297 
AI002319 AI435491 N92382 M12550 BF446684 BE791738 K02054 AI192286 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for GRP    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1:                              
SP2:              -               


ECgene alternative splicing isoforms for GRP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGCGGCAGTG
GRP Expression
About this image


GRP expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Adult Dopaminergic Neurons Ventral Tegmental Area
         Cerebellum
 
 Epithelial Cells
         Neuroendocrine Cells Stem Bronchi
 
 Primitive Streak (Early Embryonic Tissues)
         Primitive streak-like cells
 
 Bone (Muscoskeletal System)
         Mesenchymal Condensate Cells Zeugopod
 
 Neural Tube (Nervous System)
         Spinal Dorsal Columns
GRP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

GRP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.153444
    Pathway & Disease-focused RT2 Profiler PCR Arrays including GRP: 
          Angiogenic Growth Factors in human mouse rat
          Obesity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for GRP
OriGene qSTAR qPCR primer pairs in human, mouse for GRP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRP
QuantiTect SYBR Green Assays in human, mouse, rat GRP
QuantiFast Probe-based Assays in human, mouse, rat GRP
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for GRP gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Grp1 , 5 gastrin releasing peptide1, 5 78.35(n)1
70.07(a)1
  18 (38.98 cM)5
2256421  NM_175012.31  NP_778177.11 
 658728205 
chicken
(Gallus gallus)
Aves GRP1 gastrin-releasing peptide 63.31(n)
47.06(a)
  425213  NM_001277900.1  NP_001264829.1 


ENSEMBL Gene Tree for GRP (if available)
TreeFam Gene Tree for GRP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for GRP (see all 293)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 18 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1830312661,2
--56885401(+) AGTCCC/TTGTGT 3 -- us2k10--------
rs1133588211,2
C,F--56885437(+) CAGCAC/AGCCTA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
rs1504671471,2
--56885565(+) CTTTTG/TATTTT 3 -- us2k10--------
rs774356421,2
C,F--56885625(+) AAACTA/GTTAAT 3 -- us2k11Minor allele frequency- G:0.02NA 120
rs790835301,2
C,F--56885671(+) ACACAT/AGCATG 3 -- us2k11Minor allele frequency- A:0.06WA 118
rs748760041,2
C,F--56885684(+) AATACT/CCTTCA 3 -- us2k11Minor allele frequency- C:0.02WA 118
rs1151796751,2
C,F--56885762(+) CAGTGG/ACTCAT 3 -- us2k11Minor allele frequency- A:0.04WA 118
rs1122537501,2
C,F--56885795(+) GAGGCT/CACGGC 3 -- us2k12Minor allele frequency- C:0.33CSA 3
rs1873780971,2
--56885894(+) GTGCAC/TGCCTG 3 -- us2k10--------
rs1129934901,2
C--56885946(+) GAGCCG/AGGAAG 3 -- us2k11Minor allele frequency- A:0.50CSA 2

HapMap Linkage Disequilibrium report for GRP (56887400 - 56898006 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for GRP: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing GRP
DNA2.0 Custom Variant and Variant Library Synthesis for GRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 137260    OMIM disorders: --

12 diseases for GRP:    
About MalaCards
diffuse pulmonary fibrosis    anencephaly    neuroaxonal dystrophy    congenital central hypoventilation syndrome
zollinger-ellison syndrome    central hypoventilation syndrome    thyroid medullary carcinoma    pulmonary fibrosis
pancreatic cancer    colon cancer    lung cancer    prostate cancer

4 diseases from the University of Copenhagen DISEASES database for GRP:
Lung cancer     Prostate cancer     Carcinoma     Duodenal ulcer

Find genes that share disorders with GRP           About GenesLikeMe

Selected Novoseek inferred disease relationships for GRP gene (see all 93)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
small cell lung cancer 84.6 169 8262160 (3), 19031951 (3), 10470218 (3), 2169019 (2) (see all 95)
neuroendocrine tumors 65.2 10 18927341 (1), 12570813 (1), 8383784 (1), 15192313 (1) (see all 8)
prostate cancer 63.5 144 8782088 (4), 12195749 (4), 12873708 (3), 8242552 (3) (see all 68)
tumors 61.4 324 12474049 (7), 7747837 (5), 7559089 (4), 1460673 (3) (see all 99)
diffuse pulmonary fibrosis 60.9 3 7541167 (1)
carcinoid 58.8 27 14747448 (4), 16464792 (3), 1747931 (2), 1752059 (2) (see all 14)
cancer lung 58.7 75 12593474 (5), 15638385 (4), 12820318 (3), 16691010 (3) (see all 44)
prostate carcinoma 56.3 16 1434289 (2), 8661226 (1), 15866427 (1), 9247295 (1) (see all 12)
nsclc 56.2 73 20032442 (7), 10545285 (6), 17349623 (3), 15967120 (3) (see all 29)
duodenal ulcer disease 54.2 9 1639220 (2), 8613042 (1), 1763293 (1), 2253822 (1) (see all 6)

Genetic Association Database (GAD): GRP
Human Genome Epidemiology (HuGE) Navigator: GRP (5 documents)

Export disorders for GRP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for GRP gene, integrated from 10 sources (see all 1184):
(articles sorted by number of sources associating them with GRP)
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  1. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
  2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
  3. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PubMed id 18452185)1, 4 Hodges L.M....Hamilton S.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Posttranslational processing of endogenous and of baculovirus- expressed human gastrin-releasing peptide precursor. (PubMed id 3211139)1, 2 Lebacq-Verheyden A.-M.... Battey J.F. (Mol. Cell. Biol. 1988)
  6. Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. (PubMed id 3001723)1, 2 Spindel E.R.... Chin W.W. (Proc. Natl. Acad. Sci. U.S.A. 1986)
  7. Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs. (PubMed id 3003116)1, 2 Sausville E.A.... Battey J.F. (J. Biol. Chem. 1986)
  8. Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. (PubMed id 12474049)1, 9 Uchida K....Yoshimura K. (J. Cancer Res. Clin. Oncol. 2002)
  9. Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. (PubMed id 14764456)1, 9 Fang M.Z....Yang C.S. (Carcinogenesis 2004)
  10. Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. (PubMed id 12820318)1, 9 Schneider J....Katz N. (Anticancer Res. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2922 HGNC: 4605 AceView: GRP Ensembl:ENSG00000134443 euGenes: HUgn2922
ECgene: GRP H-InvDB: GRP

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for GRP Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GRP Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Gastrin_releasing_peptide

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for GRP gene:
Search GeneIP for patents involving GRP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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