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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRP Gene

protein-coding   GIFtS: 61
GCID: GC18P056861

Gastrin-Releasing Peptide

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Gastrin-Releasing Peptide1 2     GRP-102
bombesin1 2     Pre-Progastrin Releasing Peptide2
Neuromedin C1 2     preproGRP2
prepro-GRP1 2     proGRP2
BN2     

External Ids:    HGNC: 46051   Entrez Gene: 29222   Ensembl: ENSG000001344437   OMIM: 1372605   UniProtKB: P074923   

Export aliases for GRP gene to outside databases

Previous GC identifers: GC18P056719 GC18P055036 GC18P055038 GC18P053595


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRP Gene:
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following
cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the
10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central
nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial
cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach,
pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRP Gene: 
GRP (gastrin-releasing peptide) is a protein-coding gene. Diseases associated with GRP include diffuse pulmonary fibrosis, and congenital central hypoventilation syndrome, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include neuropeptide hormone activity and receptor binding.

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492
Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative
feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term
potentiation, and amygdala-dependent memory for fear (By similarity)

summary for GRP Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor).

Gene Wiki entry for GRP (Gastrin-releasing peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRP gene promoter:
         CREB   PPAR-gamma1   AP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRP promoter sequence
   Search SABiosciences Chromatin IP Primers for GRP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1-q21.32   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.1-q21.32

GRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRP gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P056861:  view genomic region     (about GC identifiers)

Start:
56,887,400 bp from pter      End:
56,898,006 bp from pter
Size:
10,607 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492 (See protein sequence)
Recommended Name: Gastrin-releasing peptide precursor  
Size: 148 amino acids; 16213 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAA52612.1; Type=Erroneous gene model prediction;
Secondary accessions: P07491 P81553 Q14454 Q53YA0 Q9BSY7
Alternative splicing: 3 isoforms:  P07492-1   P07492-2   P07492-3   

Explore the universe of human proteins at neXtProt for GRP: NX_P07492

Explore proteomics data for GRP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07492

  • GRP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRP Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001012530.1  NP_001012531.1  NP_002082.2  

    ENSEMBL proteins: 
     ENSP00000256857   ENSP00000434101   ENSP00000389696   ENSP00000397814   ENSP00000431579  
    Reactome Protein details: P07492
    Human Recombinant Protein Products for GRP: 
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    Novus Biologicals GRP Protein
    Novus Biologicals GRP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA8756537

    GRP for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for GRP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR015674 Gastrin-RP
     IPR000874 Bombesin

    Graphical View of Domain Structure for InterPro Entry P07492

    ProtoNet protein and cluster: P07492

    1 Blocks protein domain: IPB000874 Bombesin-like peptide

    UniProtKB/Swiss-Prot: GRP_HUMAN, P07492
    Similarity: Belongs to the bombesin/neuromedin-B/ranatensin family


    GRP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRP_HUMAN, P07492
    Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative
    feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term
    potentiation, and amygdala-dependent memory for fear (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding NAS3027901
    GO:0005184neuropeptide hormone activity IDA8756537
         
    GRP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRP 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GRP:
    hsa-miR-1257 hsa-miR-7 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidGRP 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for GRP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRP
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/8        Reactome Pathways for GRP (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    GRP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for GRP (P074923 ENSP000002568574) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274873, ENSP000003537314I2D: score=1 STRING: ENSP00000353731
    NCLP193383, ENSP000003181954I2D: score=1 STRING: ENSP00000318195
    PCBP1Q153653, ENSP000003055564I2D: score=1 STRING: ENSP00000305556
    GRPRP305503, ENSP000003696434I2D: score=1 STRING: ENSP00000369643
    ANKRD28O150843, ENSP000003823794I2D: score=1 STRING: ENSP00000382379
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS3027901
    GO:0007218neuropeptide signaling pathway IDA8756537

    GRP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

    10/139 Novoseek inferred chemical compound relationships for GRP gene (see all 139)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-pyrrolinodoxorubicin 83.5 6 11027415 (1), 16801542 (1), 16322338 (1), 11953892 (1)
    phyllolitorin 78.9 20 8786559 (3), 1717141 (1), 19296643 (1), 8788416 (1)
    ranatensin 78.4 11 8786559 (2), 8391296 (1), 8788416 (1)
    gastrin releasing peptide 77.5 20 16464792 (5), 7910153 (2), 10470218 (2)
    bw 2258u89 74.3 2 1332139 (2)
    minigastrin 69.3 8 17707803 (2), 17896914 (1), 19601842 (1)
    loxiglumide 67.9 19 8243522 (4), 1397878 (2), 8403798 (2), 7904286 (2) (see all 9)
    diaminopropionic acid 60.6 1 15246374 (1)
    8-aminooctanoic acid 59.5 1 17626788 (1)
    phorbol 12,13-dibutyrate 58.7 20 8314789 (3), 8408063 (2), 12692126 (2), 2022702 (1) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about GRP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRP gene (3 alternative transcripts): 
    NM_001012512.1  NM_001012513.1  NM_002091.3  

    Unigene Cluster for GRP:

    Gastrin-releasing peptide
    Hs.153444  [show with all ESTs]
    Unigene Representative Sequence: NM_002091
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256857(uc002lhu.3 uc002lhv.3 uc002lhw.3) ENST00000529320
    ENST00000420468 ENST00000456142 ENST00000530323

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate GRP:
    hsa-miR-1257 hsa-miR-7 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidGRP 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene ORF clones in mouse, rat for GRP
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    GenScript: all cDNA clones in your preferred vector: GRP (NM_001138)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRP
    Sirion Biotech Customized lentivirus for stable overexpression of GRP 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRP
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    Additional mRNA sequence: 

    AB102889.1 AK307264.1 BC004488.2 BT006803.1 K02054.1 M12550.1 

    3 DOTS entries:

    DT.121097835  DT.444537  DT.40106111 

    24/54 AceView cDNA sequences (see all 54):

    AA838825 CK903483 AI088154 N75350 BF110750 BC004488 AI375795 AI350288 
    AA456297 AI301134 AI675366 BF445372 NM_002091 BX105760 AI474286 AI268383 
    AI808774 BT006803 AI435491 AA975512 AI697753 BF446684 N92382 BE348606 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GRP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for GRP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRP expression in normal human tissues (normalized intensities)      GRP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCGGCAGTG
    GRP Expression
    About this image


    GRP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             superior temporal gyrus   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             limb/forelimb   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   
     
     Lung (Respiratory System)
             Neuroendocrine Cells Stem Bronchi

    See GRP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRP

    SOURCE GeneReport for Unigene cluster: Hs.153444
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRP: 
              Angiogenic Growth Factors in human mouse rat
              Obesity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for GRP gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grp1 , 5 gastrin releasing peptide1, 5 76.86(n)1
    69.42(a)1
      18 (38.98 cM)5
    2256421  NM_175012.21  NP_778177.11 
     658728205 
    chicken
    (Gallus gallus)
    Aves GRP6
    Gastrin-releasing peptide Neuromedin-C
    37(a)
    1 ↔ 1
    Z(911812-916640)


    ENSEMBL Gene Tree for GRP (if available)
    TreeFam Gene Tree for GRP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 SNPs in GRP are shown (see all 293)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830312661,2
    --56885401(+) AGTCCC/TTGTGT 3 -- us2k10--------
    rs1133588211,2
    C,F--56885437(+) CAGCAC/AGCCTA 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1504671471,2
    --56885565(+) CTTTTG/TATTTT 3 -- us2k10--------
    rs774356421,2
    C,F--56885625(+) AAACTA/GTTAAT 3 -- us2k11Minor allele frequency- G:0.02NA 120
    rs790835301,2
    C,F--56885671(+) ACACAT/AGCATG 3 -- us2k11Minor allele frequency- A:0.06WA 118
    rs748760041,2
    C,F--56885684(+) AATACT/CCTTCA 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1151796751,2
    C,F--56885762(+) CAGTGG/ACTCAT 3 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1122537501,2
    C,F--56885795(+) GAGGCT/CACGGC 3 -- us2k12Minor allele frequency- C:0.33CSA 3
    rs1873780971,2
    --56885894(+) GTGCAC/TGCCTG 3 -- us2k10--------
    rs1129934901,2
    C--56885946(+) GAGCCG/AGGAAG 3 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for GRP (56887400 - 56898006 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for GRP: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GRP
    DNA2.0 Custom Variant and Variant Library Synthesis for GRP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 137260    OMIM disorders: --

    20/104 diseases for GRP (see all 104):    About MalaCards
    diffuse pulmonary fibrosis    congenital central hypoventilation syndrome    paraneoplastic cerebellar degeneration    neuroaxonal dystrophy
    zollinger-ellison syndrome    breast cyst    thyroid medullary carcinoma    central hypoventilation syndrome
    primitive neuroectodermal tumor    neuroendocrine tumor    pulmonary fibrosis    anencephaly
    pulmonary neuroendocrine tumor    lambert-eaton myasthenic syndrome    prostate disease    peripheral primitive neuroectodermal tumor
    cerebellar degeneration    neuroepithelioma    duodenal ulcer    gastrinoma

    4 diseases from the University of Copenhagen DISEASES database for GRP:
    Lung cancer     Prostate cancer     Carcinoma     Duodenal ulcer

    GRP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for GRP gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 84.6 169 8262160 (3), 19031951 (3), 10470218 (3), 2169019 (2) (see all 95)
    neuroendocrine tumors 65.2 10 18927341 (1), 12570813 (1), 8383784 (1), 15192313 (1) (see all 8)
    prostate cancer 63.5 144 8782088 (4), 12195749 (4), 12873708 (3), 8242552 (3) (see all 68)
    tumors 61.4 324 12474049 (7), 7747837 (5), 7559089 (4), 1460673 (3) (see all 99)
    diffuse pulmonary fibrosis 60.9 3 7541167 (1)
    carcinoid 58.8 27 14747448 (4), 16464792 (3), 1747931 (2), 1752059 (2) (see all 14)
    cancer lung 58.7 75 12593474 (5), 15638385 (4), 12820318 (3), 16691010 (3) (see all 44)
    prostate carcinoma 56.3 16 1434289 (2), 8661226 (1), 15866427 (1), 9247295 (1) (see all 12)
    nsclc 56.2 73 20032442 (7), 10545285 (6), 17349623 (3), 15967120 (3) (see all 29)
    duodenal ulcer disease 54.2 9 1639220 (2), 8613042 (1), 1763293 (1), 2253822 (1) (see all 6)

    Genetic Association Database (GAD): GRP
    Human Genome Epidemiology (HuGE) Navigator: GRP (5 documents)

    Export disorders for GRP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRP gene, integrated from 9 sources (see all 1183):
    (articles sorted by number of sources associating them with GRP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    3. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PubMed id 18452185)1, 4 Hodges L.M....Hamilton S.P. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Posttranslational processing of endogenous and of baculovirus- expressed human gastrin-releasing peptide precursor. (PubMed id 3211139)1, 2 Lebacq-Verheyden A.-M.... Battey J.F. (1988)
    6. Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. (PubMed id 3001723)1, 2 Spindel E.R.... Chin W.W. (1986)
    7. Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs. (PubMed id 3003116)1, 2 Sausville E.A.... Battey J.F. (1986)
    8. Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. (PubMed id 12474049)1, 9 Uchida K....Yoshimura K. (2002)
    9. Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. (PubMed id 14764456)1, 9 Fang M.Z....Yang C.S. (2004)
    10. Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. (PubMed id 12820318)1, 9 Schneider J....Katz N. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2922 HGNC: 4605 AceView: GRP Ensembl:ENSG00000134443 euGenes: HUgn2922
    ECgene: GRP H-InvDB: GRP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GRP Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Gastrin_releasing_peptide

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRP gene:
    Search GeneIP for patents involving GRP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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