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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GRP Gene

protein-coding GIFtS: 59
GCID: GC18P056861

gastrin-releasing peptide

Explore 112 diseases affiliated with
GRP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Gastrin-Releasing Peptide¹ ²		Neuromedin C²
BN²		Pre-Progastrin Releasing Peptide²
GRP-10²		PreproGRP¹
Bombesin¹		ProGRP¹

External Ids:	HGNC: 4605¹	Entrez Gene: 2922²	Ensembl: ENSG00000134443⁷	OMIM: 137260⁵	UniProtKB: P07492³

Export aliases for GRP gene to outside databases

Previous GC identifers: GC18P056719 GC18P055036 GC18P055038 GC18P053595

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRP:

This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following

cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa

neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems,

including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.

These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and

prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492

Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback

regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation,

and amygdala-dependent memory for fear (By similarity)

summary for GRP:

Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B

(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor

(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The

receptors are Gq/11-coupled and are involved in the regulation of many biological functions including

sensory transmission, thermoregulation, feeding and pituitary, gastric and pancreatic secretion. They may

also be involved in tissue development, proliferation and differentiation.

Gene Wiki entry for GRP (Gastrin-releasing peptide)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GRP gene promoter:
CREB PPAR-gamma1 AP-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GRP promoter sequence

Search SABiosciences Chromatin IP Primers for GRP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1-q21.32 Ensembl cytogenetic band: 18q21.32 HGNC cytogenetic band: 18q21.1-q21.32

GRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRP gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P056861: view genomic region (about GC identifiers)

Start:	56,887,400 bp from pter	End:	56,898,006 bp from pter
Size:	10,607 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492 (See protein sequence)

Recommended Name: Gastrin-releasing peptide precursor

Size: 148 amino acids; 16213 Da

Subcellular location: Secreted

Sequence caution: Sequence=AAA52612.1; Type=Erroneous gene model prediction;

Secondary accessions: P07491 P81553 Q14454 Q53YA0 Q9BSY7

Alternative splicing: 3 isoforms: P07492-1 P07492-2 P07492-3

Explore the universe of human proteins at neXtProt for GRP: NX_P07492

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07492

GRP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001012530.1 NP_001012531.1 NP_002082.2

ENSEMBL proteins:

ENSP00000256857 ENSP00000434101 ENSP00000389696 ENSP00000397814 ENSP00000431579

Reactome Protein details: P07492
Human Recombinant Protein Products:

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	Novus Biologicals GRP Protein Novus Biologicals GRP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for GRP

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	8756537

GRP for ontologies About GeneDecksing

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Assay Products for GRP:

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	Uscn ELISAs and CLIAs for GRP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GRP for domains About GeneDecksing

2 InterPro domains/families:

IPR015674 Gastrin-RP

IPR000874 Bombesin

Graphical View of Domain Structure for InterPro Entry P07492

ProtoNet protein and cluster: P07492

1 Blocks protein family: IPB000874 Bombesin-like peptide

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492

Similarity: Belongs to the bombesin/neuromedin-B/ranatensin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492

Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback

regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation,

and amygdala-dependent memory for fear (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRP
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate GRP:
		hsa-miR-1257 hsa-miR-7 hsa-miR-507
		SwitchGear 3'UTR luciferase reporter plasmid: GRP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRP (see all 7) OriGene shRNA RFP: GRP OriGene siRNA: GRP
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GRP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRP (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRP (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GRP (NM_001138)
		Browse Sino Biological Human cDNA Clones
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GRP
		Search LifeMap BioReagents cell lines for GRP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	NAS	3027901
GO:0005184	neuropeptide hormone activity	IDA	8756537

GRP for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for GRP (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

GRP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GRP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/138 Interacting proteins for GRP (P07492³ ENSP00000256857⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 138)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487³, ENSP00000353731⁴	I2D: score=1 STRING: ENSP00000353731
NCL	P19338³, ENSP00000318195⁴	I2D: score=1 STRING: ENSP00000318195
PCBP1	Q15365³, ENSP00000305556⁴	I2D: score=1 STRING: ENSP00000305556
GRPR	P30550³, ENSP00000369643⁴	I2D: score=1 STRING: ENSP00000369643
ANKRD28	O15084³, ENSP00000382379⁴	I2D: score=1 STRING: ENSP00000382379

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	3027901
GO:0007218	neuropeptide signaling pathway	IDA	8756537

GRP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GRP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for GRP available from Tocris Bioscience About this table

Compound	Action	CAS #
Bombesin	Involved in gastrointestinal tract function	[31362-50-2]
PD 176252	GRP (BB2) and NMB (BB1) receptor antagonist	[204067-01-6]
BIM 187	Bombesin/GRP receptor agonist	[137734-88-4]
GRP (human)	Endogenous GRP receptor agonist	[93755-85-2]
BIM 189	Bombesin antagonist	[142062-55-3]

10/139 Novoseek chemical compound relationships for GRP gene (see all 139) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2-pyrrolinodoxorubicin	83.5	6	11027415 (1), 16801542 (1), 16322338 (1), 11953892 (1)
phyllolitorin	78.9	20	8786559 (3), 1717141 (1), 19296643 (1), 8788416 (1)
ranatensin	78.4	11	8786559 (2), 8391296 (1), 8788416 (1)
gastrin releasing peptide	77.5	20	16464792 (5), 7910153 (2), 10470218 (2)
bw 2258u89	74.3	2	1332139 (2)
minigastrin	69.3	8	17707803 (2), 17896914 (1), 19601842 (1)
loxiglumide	67.9	19	8243522 (4), 1397878 (2), 8403798 (2), 7904286 (2) (see all 9)
diaminopropionic acid	60.6	1	15246374 (1)
8-aminooctanoic acid	59.5	1	17626788 (1)
phorbol 12,13-dibutyrate	58.7	20	8314789 (3), 8408063 (2), 12692126 (2), 2022702 (1) (see all 10)

Search CenterWatch for drugs/clinical trials and news about GRP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GRP gene (3 alternative transcripts):

NM_001012512.1 NM_001012513.1 NM_002091.3

Unigene Cluster for GRP:

Gastrin-releasing peptide

Hs.153444 [show with all ESTs]

Unigene Representative Sequence: NM_002091

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000256857(uc002lhu.3 uc002lhv.3 uc002lhw.3) ENST00000529320

ENST00000420468 ENST00000456142 ENST00000530323

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRP
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate GRP:
		hsa-miR-1257 hsa-miR-7 hsa-miR-507
		SwitchGear 3'UTR luciferase reporter plasmid: GRP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRP (see all 7) OriGene shRNA RFP: GRP OriGene siRNA: GRP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRP (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRP (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: GRP (NM_001138)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRP

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRP

Additional cDNA sequence:

AB102889.1 AK307264.1 BC004488.2 BT006803.1 K02054.1 M12550.1

3 DOTS entries:

DT.121097835 DT.444537 DT.40106111

24/54 AceView cDNA sequences (see all 54):

AI268383 AI375795 AI088154 AI301134 NM_002091 BF445372 AA838825 BX105760

AI474286 BF110750 N75350 AI350288 AI675366 BC004488 CK903483 AA456297

AI435491 BE348606 BT006803 BE791738 BF589155 AI697753 K02054 N92382

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for GRP About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b
SP1:
SP2:					-

ECgene alternative splicing isoforms for GRP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GRP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCGGCAGTG

About this image

GRP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Cord

Spinal Dorsal Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Primitive streak-like cells (Generation of endode...)

Definitive endoderm-like cells (A scalable, suspensi...)

See GRP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRP

SOURCE GeneReport for Unigene cluster: Hs.153444

SABiosciences Expression via Pathway-Focused PCR Arrays including GRP:

Angiogenic Growth Factors in human mouse rat

Obesity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for GRP gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Grp^{1 , 5}	gastrin releasing peptide^{1, 5}	76.86(n)¹ 69.42(a)¹		18 (38.98 cM)⁵ 225642¹ NM_175012.2¹ NP_778177.1¹ 65872820⁵

ENSEMBL Gene Tree for GRP (if available)
TreeFam Gene Tree for GRP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72956177^1,2	C,	--	53602361(+)	`TTCTTC/TCTTTC`	1	--	int¹		1		WA	2
rs183031266^1,2		--	56885401(+)	`AGTCCC/TTGTGT`	3	--	us2k¹		0	--	--	--	--
rs113358821^1,2		--	56885437(+)	`CAGCAC/AGCCTA`	3	--	us2k¹		1		CSA	2
rs150467147^1,2		--	56885565(+)	`CTTTTG/TATTTT`	3	--	us2k¹		0	--	--	--	--
rs77435642^1,2	F,	--	56885625(+)	`AAACTA/GTTAAT`	3	--	us2k¹		1		NA	120
rs79083530^1,2	C,F,	--	56885671(+)	`ACACAT/AGCATG`	3	--	us2k¹		1		WA	118
rs74876004^1,2	C,F,	--	56885684(+)	`AATACT/CCTTCA`	3	--	us2k¹		1		WA	118
rs115179675^1,2	F,	--	56885762(+)	`CAGTGG/ACTCAT`	3	--	us2k¹		1		WA	118
rs112253750^1,2		--	56885795(+)	`GAGGCT/CACGGC`	3	--	us2k¹		2		CSA	3
rs187378097^1,2		--	56885894(+)	`GTGCAC/TGCCTG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GRP (56887400 - 56898006 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GRP: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRP

DNA2.0 Custom Variant and Variant Library Synthesis for GRP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GRP for disorders           About GeneDecksing

OMIM gene information: 137260    OMIM disorders: --

20/112 diseases for GRP (see all 112):    About MalaCards

zollinger-ellison syndrome lambert-eaton myasthenic syndrome primitive neuroectodermal tumor central hypoventilation syndrome

pancreatitis prostatitis sudden infant death syndrome congenital central hypoventilation syndrome

peripheral primitive neuroectodermal tumor paraneoplastic cerebellar degeneration non-small cell lung carcinoma diffuse pulmonary fibrosis

neuroectodermal tumors duodenal ulcer bronchopulmonary dysplasia cerebellar degeneration

pulmonary fibrosis neuroaxonal dystrophy myasthenic syndrome neuroendocrine tumor

4 diseases from the University of Copenhagen DISEASES database for GRP:

Lung cancer Prostate cancer Carcinoma Duodenal ulcer

10/93 Novoseek disease relationships for GRP gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
small cell lung cancer	84.6	169	8262160 (3), 19031951 (3), 10470218 (3), 2169019 (2) (see all 95)
neuroendocrine tumors	65.2	10	18927341 (1), 12570813 (1), 8383784 (1), 15192313 (1) (see all 8)
prostate cancer	63.5	144	8782088 (4), 12195749 (4), 12873708 (3), 8242552 (3) (see all 68)
tumors	61.4	324	12474049 (7), 7747837 (5), 7559089 (4), 1460673 (3) (see all 99)
diffuse pulmonary fibrosis	60.9	3	7541167 (1)
carcinoid	58.8	27	14747448 (4), 16464792 (3), 1747931 (2), 1752059 (2) (see all 14)
cancer lung	58.7	75	12593474 (5), 15638385 (4), 12820318 (3), 16691010 (3) (see all 44)
prostate carcinoma	56.3	16	1434289 (2), 8661226 (1), 15866427 (1), 9247295 (1) (see all 12)
nsclc	56.2	73	20032442 (7), 10545285 (6), 17349623 (3), 15967120 (3) (see all 29)
duodenal ulcer disease	54.2	9	1639220 (2), 8613042 (1), 1763293 (1), 2253822 (1) (see all 6)

Human Genome Epidemiology (HuGE) Navigator: GRP (5 documents)

Export disorders for GRP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GRP gene, integrated from 9 sources (see all 1179):
(articles sorted by number of sources associating them with GRP)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Posttranslational processing of endogenous and of baculovirus- expressed human gastrin-releasing peptide precursor. (PubMed id 3211139)^{1, 2} Lebacq-Verheyden A.-M.... Battey J.F. (1988)
Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. (PubMed id 3001723)^{1, 2} Spindel E.R.... Chin W.W. (1986)
Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs. (PubMed id 3003116)^{1, 2} Sausville E.A.... Battey J.F. (1986)
Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. (PubMed id 12474049)^{1, 9} Uchida K....Yoshimura K. (2002)
Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. (PubMed id 14764456)^{1, 9} Fang M.Z....Yang C.S. (2004)
Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. (PubMed id 12820318)^{1, 9} Schneider J....Katz N. (2003)
Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. (PubMed id 15750618)^{1, 9} Martinez A....Cuttitta F. (2005)
Gastrin-releasing peptide-induced down-regulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) in neuroblastomas. (PubMed id 15849504)^{1, 9} Qiao J....Chung D.H. (2005)
Serum levels of osteoprotegerin (OPG) and pro gastrin releasing peptide (ProGRP) during chemotherapy of lung cancer. (PubMed id 15638385)^{1, 9} Naumnik W....Ossolinska M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2922	HGNC: 4605	AceView: GRP	Ensembl:ENSG00000134443	euGenes: HUgn2922
ECgene: GRP	H-InvDB: GRP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GRP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GRP	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Gastrin_releasing_peptide

Intellectual Property for GRP gene
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