Aliases for GRP Gene
External Ids for GRP Gene
Previous GeneCards Identifiers for GRP Gene
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRP Gene
GRP (Gastrin-Releasing Peptide) is a Protein Coding gene. Diseases associated with GRP include splenic tuberculosis and urinary bladder small cell neuroendocrine carcinoma. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.
UniProtKB/Swiss-Prot for GRP Gene
GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity).
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).