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GRP Gene

protein-coding GIFtS: 62

GC18P055038

gastrin-releasing peptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BN ^²
GRP-10 ^²
bombesin ^²
preproGRP ^²
proGRP ^²

Descriptions
gastrin-releasing peptide ^²
neuromedin C ^²
pre-progastrin releasing peptide ^²

External Ids
HGNC: 4605¹
Entrez Gene: 2922²
UniProtKB: P07492³
Ensembl: ENSG00000134443⁷

Search outside databases for aliases for GRP gene

Previous GC identifers: GC18P056719 GC18P056861 GC18P055036

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRP:

This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its

preproprotein, following cleavage of a signal peptide, is further processed to produce either the

27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate

numerous functions of the gastrointestinal and central nervous systems, including release of

gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.

These peptides are also likely to play a role in human cancers of the lung, colon, stomach,

pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants

encoding different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492

Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a

negative feedback regulating fear and established a causal relationship between GRP-receptor gene

expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity)

Gene Wiki entry for GRP (Gastrin_releasing_peptide)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRP gene

Entrez Gene cytogenetic band: 18q21.1-q21.32 Ensembl cytogenetic band: 18q21.32 HGNC cytogenetic band: 18q21.1-q21.32

GRP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P055038: (about GC identifiers)

Start:	55,038,380 bp from pter
End:	55,048,983 bp from pter
Size:	10,604 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_025028.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492 (See protein sequence)

Recommended Name: Gastrin-releasing peptide precursor

Size: 148 amino acids; 16144 Da

Subcellular location: Secreted

Secondary accessions: P07491 P81553 Q14454 Q9BSY7

Alternative splicing: 3 isoforms: P07492-1 P07492-2 P07492-3

REFSEQ proteins (3 alternative transcripts):

NP_001012530.1 NP_001012531.1 NP_002082.2

ENSEMBL proteins:

ENSP00000256857

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for GRP
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Gastrin Releasing Peptide, Neuromedin C)
	Human Recombinant Proteins from Abnova (GRP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IDA	8756537

About this table

Antibodies for GRP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GRP
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for GRP (grp75)
	Antibodies from Abcam (Gastrin Releasing Peptide, Neuromedin C), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GRP)
	Novus Biologicals Antibody for GRP

Assays for GRP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07492

ProtoNet protein and cluster: P07492

1 Blocks protein family: IPB000874 Bombesin-like peptide

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492

Similarity: Belongs to the bombesin/neuromedin-B/ranatensin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001012512

Applied Biosystems Silencer® siRNAs for GRP

Sigma-Aldrich siRNA for GRP

Sigma-Aldrich shRNA for GRP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001012512
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001012512
untagged cDNA clones in CMV expression vector (see all 3): NM_001012512

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002091

UniProtKB/Swiss-Prot: GRP_HUMAN, P07492

Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a

negative feedback regulating fear and established a causal relationship between GRP-receptor gene

expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	NAS	3027901
GO:0005184	neuropeptide hormone activity	IDA	8756537

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for GRP

5/19 Interacting proteins for GRP (ENSP00000256857³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRPR	ENSP00000369643³	STRING (score=.989)
NMBR	ENSP00000258042³	STRING (score=.965)
NMB	ENSP00000353664³	STRING (score=.958)
PTGS2	ENSP00000356438³	STRING (score=.839)
NPY	ENSP00000242152³	STRING (score=.809)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	3027901
GO:0007218	neuropeptide signaling pathway	IDA	8756537

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for GRP available from Tocris Bioscience

Compound	Action	CAS number
PD 176252	GRP (BB2) and NMB (BB1) receptor antagonist	[204067-01-6]
Bombesin	Involved in gastrointestinal tract function	[31362-50-2]
GRP (human)	Endogenous GRP receptor agonist	[93755-85-2]
BIM 187	Bombesin/GRP receptor agonist	[137734-88-4]
BIM 189	Bombesin antagonist	[142062-55-3]

About this table

10/48 Novoseek chemical compound relationships for GRP gene (see all 48 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2-pyrrolinodoxorubicin	83.70	6	11027415 (1), 16801542 (1), 16322338 (1), 11953892 (1)
ranatensin	79.24	11	8786559 (2), 8391296 (1), 8788416 (1)
phyllolitorin	79.20	20	8786559 (3), 1717141 (1), 19296643 (1), 8788416 (1)
bw 2258u89	71.32	2	1332139 (2)
minigastrin	65.45	1	17707803 (2), 17896914 (1)
8-aminooctanoic acid	60.71	1	17626788 (1)
phorbol 12,13-dibutyrate	57.94	18	8314789 (3), 8408063 (2), 12692126 (2), 2022702 (1) (see all 9)
enterostatin	57.57	2	9208352 (1), 8489134 (1)
tyrosine	54.24	128	8408063 (5), 7683655 (5), 8910389 (5), 1721065 (3) (see all 60)
calcium	52.05	240	9828595 (8), 8842515 (6), 10465509 (5), 1846353 (5) (see all 99)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001012512

Sigma-Aldrich siRNA for GRP

Sigma-Aldrich shRNA for GRP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001012512 NM_001012513 NM_002091

REFSEQ mRNAs for GRP gene (3 alternative transcripts):

NM_001012512.1 NM_001012513.1 NM_002091.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001012512 NM_001012513 NM_002091

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001012512
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001012512
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001012512

Additional cDNA sequence:

AB102889.1 AK307264.1 BC004488.2 BT006803.1 K02054.1 M12550.1

3 DOTS entries:

DT.121097835 DT.444537 DT.40106111

24/54 AceView cDNA sequences (see all 54 ):

BF445372 AA456297 AA838825 NM_002091 BX105760 AI268383 BC004488 BF110750

AI350288 AI088154 AI675366 AI474286 AI375795 AI301134 CK903483 N75350

BF446684 AA975512 BE791738 AI435491 AI808774 AI002319 AI697753 K02054

highest scoring ESTs for GRP:

K02054 AA026118 AA031935 AA063460 AA148820 AA456297 AA456694 AA707890 AA757848 AA838825

Unigene Cluster for GRP:

Gastrin-releasing peptide

Hs.153444 [show with all ESTs]

Unigene Representative Sequence: NM_002091

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for GRP

ExUns:	1	^	2a	·	2b	^	3a	·	3b
SP1:
SP2:					-

About this scheme

ECgene alternative splicing isoforms for GRP

1 Ensembl transcript including schematic representation:

ENST00000256857

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GRP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRP

¹ / ² / ³

4 probe-sets matching GRP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
272_at²^{, 3}	U95-A	1	1.00	1.00	0.50	1.08	K02054	1.00	1.00	1.00	1
273_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.93	K02054	1.00	1.00	1.00	1
206326_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002091	0.60	1.00	0.82	1
206326_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGCGGCAGTG

SOURCE GeneReport for Unigene cluster: Hs.153444
Expression variation in blood from EXPOLDB for GRP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRP gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	GRP¹	--	gastrin-releasing peptide	99.77(n) 99.32(a)	736808 XM_001142106.1 XP_001142106.1
cow (Bos taurus)	GRP¹	--	gastrin-releasing peptide	78.36(n) 69.4(a)	615323 XM_867101.2 XP_872194.2
rat (Rattus norvegicus)	Grp¹	--	gastrin releasing peptide	70.71(n) 64.29(a)	171101 NM_133570.3 NP_598254.1
mouse (Mus musculus)	Grp^{1, 5}	18 (40.00 cM)⁵	gastrin releasing peptide^{1, 5}	76.86(n)¹ 69.42(a)¹	225642¹ NM_175012.2¹ NP_778177.1¹ AI324084⁵ AI840702⁵ (see all 8)

About this table Species with no ortholog for GRP

ENSEMBL Gene Tree for GRP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/82 NCBI SNPs in GRP are shown (see all 82 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 48)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1062557^1,2	A,C,F,H	55038487(+)	`GCGGCA/CGTGAG`	3	R/S	mis¹ ese³		14	EA MN NA EU WA	2726
	rs11873324^1,2	A,C,H	55049427(+)	`TTAAAC/TGTCCC`	3	--	ng3¹		4	EU EA WA	418
	rs1563713^1,2	A,C,F,H,O	55042364(-)	`GGCAAC/TGTCTT`	3	--	int¹		14	EU EA WA NA	1232
	rs1533478^1,2	A,C,F,H	55044682(-)	`ATTCAG/CTAAAA`	3	--	int¹		4	EU EA WA	418
	rs1533477^1,2	A,C,F,H	55044808(-)	`TATGGG/AACTAG`	3	--	int¹		6	NA EU EA WA	454
	rs11872122^1,2	A,C,F,H	55044237(+)	`CCTACA/CAGAAT`	3	--	int¹		11	EU EA WA NA	978
	rs10221365^1,2	A,C,F,H	55047659(+)	`CAGGCG/AGCAGG`	3	--	int¹		8	EU EA WA	838
	rs17065639^1,2	C,F,H	55040767(+)	`CTCTGT/CTGGAA`	3	--	int¹		7	NA EU EA WA	518
	rs936431^1,2	C,F,H	55039736(-)	`TCCCAC/AGAAGC`	3	--	int¹		6	NA EU EA WA	446
	rs11875195^1,2	C,F,H	55044855(+)	`TCAGTC/TGGCCT`	3	--	int¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for GRP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 137260

10/94 Novoseek disease relationships for GRP gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
small cell lung cancer	84.64	165	8262160 (3), 19031951 (3), 10470218 (3), 2169019 (2) (see all 91)
prostate cancer	63.39	141	8782088 (4), 12195749 (4), 12873708 (3), 8242552 (3) (see all 67)
neuroendocrine tumors	61.99	10	18927341 (1), 12570813 (1), 8383784 (1), 15192313 (1) (see all 8)
tumors	60.83	304	12474049 (7), 7747837 (5), 7559089 (4), 1460673 (3) (see all 99)
cancer lung	59.03	67	12593474 (5), 15638385 (4), 12820318 (3), 16691010 (3) (see all 41)
carcinoid	58.68	27	14747448 (4), 16464792 (3), 1747931 (2), 1752059 (2) (see all 14)
nsclc	56.31	64	10545285 (6), 17349623 (3), 15967120 (3), 8018339 (2) (see all 27)
prostate carcinoma	55.15	16	1434289 (2), 8661226 (1), 15866427 (1), 9247295 (1) (see all 12)
gastrinoma	54.15	12	2101791 (2), 1455308 (2), 8943970 (2), 7962132 (1) (see all 6)
diffuse pulmonary fibrosis	53.21	2	7541167 (1)

About this table

Human Genome Epidemiology Navigator: GRP (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1064 PubMed articles for GRP gene (see all 1064 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Posttranslational processing of endogenous and of baculovirus- expressed human gastrin-releasing peptide precursor. (PubMed id 3211139)^{3, 4} Lebacq-Verheyden A.-M.... Battey J.F. (1988)
Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. (PubMed id 3001723)^{3, 4} Spindel E.R.... Chin W.W. (1986)
Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs. (PubMed id 3003116)^{3, 4} Sausville E.A.... Battey J.F. (1986)
Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. (PubMed id 12474049)^{1, 3} Uchida K....Yoshimura K. (2002)
Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. (PubMed id 14764456)^{1, 3} Fang M.Z....Yang C.S. (2004)
Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. (PubMed id 12820318)^{1, 3} Schneider J....Katz N. (2003)
Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. (PubMed id 15750618)^{1, 3} Martinez A....Cuttitta F. (2005)
Gastrin-releasing peptide-induced down-regulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) in neuroblastomas. (PubMed id 15849504)^{1, 3} Qiao J....Chung D.H. (2005)
Serum levels of osteoprotegerin (OPG) and pro gastrin releasing peptide (ProGRP) during chemotherapy of lung cancer. (PubMed id 15638385)^{1, 3} Naumnik W....Ossolinska M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2922	HGNC: 4605	AceView: GRP	Ensembl:ENSG00000134443	euGenes: HUgn2922
ECgene: GRP	H-InvDB: GRP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for GRP	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Gastrin_releasing_peptide

Licensable Technologies for GRP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GRP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRP		Antibodies for GRP
	Explore super-pooled esiRNAs		Proteins for GRP
	Lentivirus-delivered shRNAs for GRP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GRP)
	Antibodies (GRP)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GRP (grp75)

	Recombinant Proteins (Gastrin Releasing Peptide, Neuromedin C)
	Antibodies (Gastrin Releasing Peptide, Neuromedin C)

Search OriGene for GRP

Tocris compounds for GRP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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GRP Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for GRP

Summaries
for GRP

Genomic Location
for GRP

Proteins
for GRP

Protein Domains/
Families
for GRP

Gene Function
for GRP

Pathways & Interactions
for GRP

Drugs & Compounds
for GRP

Transcripts
for GRP

Expression
for GRP

Orthologs
for GRP

Paralogs
for GRP

SNPs/Variants
for GRP

Disorders & Mutations
for GRP

Medical News
for GRP

Publications
for GRP

Search for GRP

Genome Databases showing GRP

Other Databases showing GRP

Specialized Databases showing GRP

Licensable Technologies
for GRP

Services
for GRP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRP Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor GRP

Summariesfor GRP

Genomic Locationfor GRP

Proteinsfor GRP

Protein Domains/Familiesfor GRP

Gene Functionfor GRP

Pathways & Interactionsfor GRP

Drugs & Compoundsfor GRP

Transcriptsfor GRP

Expression for GRP

Orthologsfor GRP

Paralogsfor GRP

SNPs/Variantsfor GRP

Disorders & Mutationsfor GRP

Medical Newsfor GRP

Publicationsfor GRP

Search for GRP

Genome Databases showing GRP

Other Databases showing GRP

Specialized Databases showing GRP

Licensable Technologiesfor GRP

Servicesfor GRP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRP

Summaries
for GRP

Genomic Location
for GRP

Proteins
for GRP

Protein Domains/
Families
for GRP

Gene Function
for GRP

Pathways & Interactions
for GRP

Drugs & Compounds
for GRP

Transcripts
for GRP

Expression
for GRP

Orthologs
for GRP

Paralogs
for GRP

SNPs/Variants
for GRP

Disorders & Mutations
for GRP

Medical News
for GRP

Publications
for GRP

Licensable Technologies
for GRP

Services
for GRP