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Aliases for GRP Gene

Aliases for GRP Gene

  • Gastrin-Releasing Peptide 2 3
  • Neuromedin C 2 3
  • Prepro-GRP 2 3
  • Bombesin 2 3
  • Pre-Progastrin Releasing Peptide 3
  • PreproGRP 3
  • GRP-10 3
  • ProGRP 3
  • BN 3

External Ids for GRP Gene

Previous GeneCards Identifiers for GRP Gene

  • GC18P056719
  • GC18P056861
  • GC18P055036
  • GC18P055038
  • GC18P053595

Summaries for GRP Gene

Entrez Gene Summary for GRP Gene

  • This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRP Gene

GRP (Gastrin-Releasing Peptide) is a Protein Coding gene. Diseases associated with GRP include diffuse pulmonary fibrosis and neuroaxonal dystrophy. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for GRP Gene

  • GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity).

Tocris Summary for GRP Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor)

Gene Wiki entry for GRP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRP Gene

Genomics for GRP Gene

Regulatory Elements for GRP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRP Gene

Start:
59,220,168 bp from pter
End:
59,230,774 bp from pter
Size:
10,607 bases
Orientation:
Plus strand

Genomic View for GRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRP Gene

Proteins for GRP Gene

  • Protein details for GRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07492-GRP_HUMAN
    Recommended name:
    Gastrin-releasing peptide
    Protein Accession:
    P07492
    Secondary Accessions:
    • P07491
    • P81553
    • Q14454
    • Q53YA0
    • Q9BSY7

    Protein attributes for GRP Gene

    Size:
    148 amino acids
    Molecular mass:
    16213 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA52612.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRP Gene

Proteomics data for GRP Gene at MOPED

Post-translational modifications for GRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRP Gene

No data available for DME Specific Peptides for GRP Gene

Domains for GRP Gene

Gene Families for GRP Gene

HGNC:

Protein Domains for GRP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GRP Gene

Graphical View of Domain Structure for InterPro Entry

P07492

UniProtKB/Swiss-Prot:

GRP_HUMAN :
  • P07492
Family:
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
genes like me logo Genes that share domains with GRP: view

Function for GRP Gene

Molecular function for GRP Gene

UniProtKB/Swiss-Prot Function: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear (By similarity).

Gene Ontology (GO) - Molecular Function for GRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding NAS 3027901
GO:0005184 neuropeptide hormone activity IDA 8756537
genes like me logo Genes that share ontologies with GRP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for GRP Gene

Localization for GRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRP Gene COMPARTMENTS Subcellular localization image for GRP gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 8756537
genes like me logo Genes that share ontologies with GRP: view

Pathways for GRP Gene

genes like me logo Genes that share pathways with GRP: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 3027901
GO:0007218 neuropeptide signaling pathway IDA 8756537
genes like me logo Genes that share ontologies with GRP: view

Compounds for GRP Gene

(5) Tocris Compounds for GRP Gene

Compound Action Cas Number
BIM 23042 Selective neuromedin B receptor antagonist (NMB-R, BB1) [111857-96-6]
Bombesin Involved in gastrointestinal tract function [31362-50-2]
GRP (human) Endogenous GRP receptor agonist [93755-85-2]
GRP (porcine) Endogenous GRP receptor agonist [74815-57-9]
PD 176252 GRP (BB2) and NMB (BB1) receptor antagonist [204067-01-6]

(139) Novoseek inferred chemical compound relationships for GRP Gene

Compound -log(P) Hits PubMed IDs
2-pyrrolinodoxorubicin 83.5 4
phyllolitorin 78.9 6
ranatensin 78.4 4
gastrin releasing peptide 77.5 9
bw 2258u89 74.3 2
genes like me logo Genes that share compounds with GRP: view

Transcripts for GRP Gene

Unigene Clusters for GRP Gene

Gastrin-releasing peptide:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for GRP Gene

GeneLoc Exon Structure for
GRP
ECgene alternative splicing isoforms for
GRP

Expression for GRP Gene

mRNA expression in normal human tissues for GRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRP Gene

This gene is overexpressed in Brain - Hippocampus (7.3), Stomach (6.8), and Brain - Substantia nigra (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRP Gene

SOURCE GeneReport for Unigene cluster for GRP Gene Hs.153444

genes like me logo Genes that share expressions with GRP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRP Gene

Orthologs for GRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRP 35
  • 99.76 (n)
  • 99.28 (a)
GRP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRP 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRP 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grp 35
  • 78.35 (n)
  • 70.07 (a)
Grp 16
Grp 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRP 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRP 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grp 35
  • 80.43 (n)
  • 72.46 (a)
chicken
(Gallus gallus)
Aves GRP 35
  • 63.31 (n)
  • 47.06 (a)
GRP 36
  • 38 (a)
OneToOne
Species with no ortholog for GRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GRP Gene

ENSEMBL:
Gene Tree for GRP (if available)
TreeFam:
Gene Tree for GRP (if available)

Paralogs for GRP Gene

No data available for Paralogs for GRP Gene

Variants for GRP Gene

Sequence variations from dbSNP and Humsavar for GRP Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2742 -- 59,230,539(+) TTCTA(C/T)GGATC utr-variant-3-prime
rs15526 -- 59,225,715(+) AAAGA(C/T)GTAGG synonymous-codon, reference
rs936431 -- 59,221,524(-) TCCCA(A/C)GAAGC intron-variant
rs1042431 -- 59,220,316(+) TGCCT(A/G)GCGCC synonymous-codon, reference
rs1062557 - 59,220,275(+) GCGGC(A/C)GTGAG missense, reference

Relevant External Links for GRP Gene

HapMap Linkage Disequilibrium report
GRP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GRP Gene

Disorders for GRP Gene

(4) University of Copenhagen DISEASES for GRP Gene

(93) Novoseek inferred disease relationships for GRP Gene

Disease -log(P) Hits PubMed IDs
small cell lung cancer 84.6 115
neuroendocrine tumors 65.2 8
prostate cancer 63.5 101
tumors 61.4 157
diffuse pulmonary fibrosis 60.9 1

Relevant External Links for GRP

Genetic Association Database (GAD)
GRP
Human Genome Epidemiology (HuGE) Navigator
GRP
genes like me logo Genes that share disorders with GRP: view

No data available for UniProtKB/Swiss-Prot for GRP Gene

Publications for GRP Gene

  1. Receptor subtype expression and responsiveness to bombesin in cultured human bronchial epithelial cells. (PMID: 8137267) Frankel A. … Viallet J. (Cancer Res. 1994) 3 23
  2. Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract. (PMID: 11960700) Carroll R.E. … Benya R.V. (Mech. Dev. 2002) 3 23
  3. Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. (PMID: 12474049) Uchida K. … Yoshimura K. (J. Cancer Res. Clin. Oncol. 2002) 3 23
  4. Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases. (PMID: 12820318) Schneider J. … Katz N. (Anticancer Res. 2003) 3 23
  5. Pro-gastrin-releasing peptide (Pro-GRP), a tumor marker for small cell lung cancer. (PMID: 12820319) Oremek G.M. … Sapoutzis N. (Anticancer Res. 2003) 3 23

Products for GRP Gene

  • Addgene plasmids for GRP

Sources for GRP Gene

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