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CXCL2 Gene

protein-coding GIFtS: 56

GC04M075202

chemokine (C-X-C motif) ligand 2
(Previous name: GRO2 oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GRO2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CINC-2a ^¹, ²
GRO2 ^², ³, ⁵
GROB ^³
GROb ^¹, ²
Gro-beta ^³
MGSA-b ^¹, ²
MIP-2a ^¹, ²
MIP2 ^²
MIP2-alpha ^³
MIP2A ^², ³, ⁵
SCYB2 ^¹, ², ³

Descriptions
GRO2 oncogene ^¹, ²
Growth-regulated protein beta ^³
MGSA beta ^²
Macrophage inflammatory protein 2-alpha ^³
chemokine (C-X-C motif) ligand 2 ^²
melanoma growth stimulatory activity beta ^²

External Ids
HGNC: 4603¹
Entrez Gene: 2920²
UniProtKB: P19875³
Ensembl: ENSG00000081041⁷

Search outside databases for aliases for CXCL2 gene

Previous GC identifers: GC04M074951 GC04M075363 GC04M075429 GC04M075329

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation.

Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell

proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CXCL2 gene

Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3

CXCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M075202: (about GC identifiers)

Start:	75,169,527 bp from pter
End:	75,183,874 bp from pter
Size:	14,348 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_006216.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875 (See protein sequence)

Recommended Name: C-X-C motif chemokine 2 precursor

Size: 107 amino acids; 11389 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1QNK (3D)

Secondary accessions: Q9UPB8

Post-translational modifications:

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion

from bone marrow stromal cells¹

REFSEQ proteins: NP_002080.1

ENSEMBL proteins:

ENSP00000264492 ENSP00000379110

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CXCL2 (CXCL2/GRO beta/MIP-2/CINC-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRO beta)
	Human Recombinant Proteins from Abnova (CXCL2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	9873037
GO:0005625	soluble fraction	TAS	2643119

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Antibodies for CXCL2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for CXCL2 (CXCL2/GRO beta/MIP-2/CINC-3)
	Antibodies from Abcam (GRO beta), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for CXCL2

Assays for CXCL2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P19875

ProtoNet protein and cluster: P19875

1 Blocks protein family: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002089

Applied Biosystems Silencer® siRNAs for CXCL2

Sigma-Aldrich siRNA for CXCL2

Sigma-Aldrich shRNA for CXCL2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CXCL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002089
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002089
untagged cDNA clones in CMV expression vector (see all 2): NM_002089

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002089

UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Function: Produced by activated monocytes and neutrophils and expressed at sites of inflammation.

Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell

proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	TAS	9873037

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CXCL2

5/51 Interacting proteins for CXCL2 (ENSP00000264492³ P19875²) via UniProtKB, MINT, and/or STRING (see all 51 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²	MINT-6491490
IL8RB	ENSP00000319635³	STRING (score=.998)
CCL3	ENSP00000225245³	STRING (score=.961)
TLR2	ENSP00000260010³	STRING (score=.949)
TLR4	ENSP00000363089³	STRING (score=.945)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	TAS	2643119
GO:0006954	inflammatory response	TAS	2643119
GO:0006955	immune response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CXCL2
UniProtKB/Swiss-Prot: CXCL2_HUMAN, P19875

Pharmaceutical: GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is

used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and

reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias

10/28 Novoseek chemical compound relationships for CXCL2 gene (see all 28 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
grogamma	90.78	14	8702798 (5), 15832427 (2), 9553055 (2), 10695618 (1) (see all 7)
grobeta	90.74	32	8702798 (5), 16540656 (4), 15292528 (3), 15832427 (2) (see all 10)
groalpha	78.02	9	8702798 (2), 16540656 (2), 10695618 (1), 12547709 (1) (see all 6)
rantes	73.22	38	10505748 (3), 17015748 (3), 7682242 (2), 10531235 (2) (see all 26)
ccl3	69.35	9	15585879 (2), 14734774 (1), 16552065 (1), 12905486 (1) (see all 7)
tmtu	60.93	2	9726445 (1), 9707512 (1)
endotoxin	40.97	4	11705739 (2), 14504103 (1), 10768990 (1)
tarc	37.43	3	15941911 (2), 11001915 (1)
8-oxo-dg	27.89	1	15337697 (1)
ccl4	26.59	6	14734774 (1), 19120450 (1), 16552065 (1), 18340639 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CXCL2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002089

Sigma-Aldrich siRNA for CXCL2

Sigma-Aldrich shRNA for CXCL2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002089

REFSEQ mRNAs for CXCL2 gene:

NM_002089.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002089

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002089
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002089
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002089

Additional cDNA sequence:

AF043340.1 AK308504.1 AK311304.1 BC015753.1 CR542171.1 CR601860.1 CR602080.1 CR617096.1

M36820.1 M57731.1 X53799.1

10 DOTS entries:

DT.40314945 DT.40313580 DT.101968867 DT.121273395 DT.100786999 DT.95299876 DT.100786997 DT.92445243

DT.95299860 DT.101987218

24/122 AceView cDNA sequences (see all 122 ):

CA865685 CR602080 CD240332 BM820337 BM772327 BM749667 CR617096 C02042

BM763035 CD367441 CR601860 CA309975 BX397603 BM756509 CR542171 AA362186

BF847972 BM771156 AW103962 BM923815 X53799 AA487664 CA865443 BM768469

highest scoring ESTs for CXCL2:

M36820 BC005276 BC015753 BC053653 BF126645 BG547218 BG569875 BG752013 BI223477 BI837665

Unigene Cluster for CXCL2:

Chemokine (C-X-C motif) ligand 2

Hs.75765 [show with all ESTs]

Unigene Representative Sequence: CR601860

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000264492 ENST00000395761

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CXCL2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CXCL2

¹ / ² / ³

4 probe-sets matching CXCL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37187_at²^{, 3}	U95-A	2	1.00	0.88	1.00	1.00	M36820	1.00	1.00	1.00	1
209774_x_at²^{, 3}	U133-A	2	1.00	0.86	--	--	M57731	0.80	1.00	0.91	1
209774_x_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--
1569203_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks CXCL2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.75765
Expression variation in blood from EXPOLDB for CXCL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CXCL2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CXCL2¹	--	chemokine (C-X-C motif) ligand 2	98.44(n) 96.26(a)	740176 XM_001155614.1 XP_001155614.1
cow (Bos taurus)	CXCL2¹	--	chemokine (C-X-C motif) ligand 2	85.46(n) 82.98(a)	281214 NM_174299.2 NP_776724.1
rat (Rattus norvegicus)	Cxcl1¹	--	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating more	79.17(n) 71.25(a)	81503 NM_030845.1 NP_110472.1
mouse (Mus musculus)	Cxcl2⁵ Cxcl1¹	5 (51.00 cM)⁵	chemokine (C-X-C motif) ligand 2⁵ chemokine (C-X-C motif) ligand 1¹	77.04(n)¹ 70(a)¹	14825¹ NM_008176.2¹ NP_032202.1¹ AK137628⁵ AK150450⁵ (see all 13)

About this table Species with no ortholog for CXCL2

ENSEMBL Gene Tree for CXCL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CXCL2 gene

CXCL3² CXCL5² PF4² PPBP² CXCL1² IL8² PF4V1² CXCL6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in CXCL2 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 16)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9131^1,2	A,C,F,H,O	75181913(-)	`CCAGTA/GAGATC`	1	--	ut3¹ ese³		19		MN EA NA EU WA	1823
	rs3806792^1,2	C,F,H	75184138(+)	`CATCCC/TTACCG`	1	--	ng3¹		5		NA EU EA WA	454
	rs11574448^1,2	H	75184426(-)	`CCTGGC/ATCCAC`	1	--	ng3¹		5		NA EU EA WA	440
--	rs6832638^1,2	H	75183192(+)	`CAGCAT/ACTTTT`	1	L/M	mis¹ ese³		4		EU EA WA	406
	rs1837558^1,2	C,H	75182448(-)	`ATTCAG/AAAAAC`	1	--	int¹		5		MN EU EA WA	588
--	rs72207736^1,2	--	75184374(+)	`TGTGT-/GTGTGTG`	1	--	ng3¹		0	--	--	--	--
--	rs11574449^1,2	--	75183829(-)	`ACTCCG/CGGCTT`	1	--	ut5¹ ese³		1		NA	40
--	rs10670819^1,2	--	75182170(+)	`ACAaa-/CAAA taaat`	1	--	ut3¹		0	--	--	--	--
--	rs36081048^1,2	--	75182168(+)	`AAACA-/AAAT AATAA`	1	--	ut3¹		0	--	--	--	--
--	rs35705658^1,2	--	75182177(+)	`AATAA-/AATA ATAAA`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CXCL2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 139110

10/33 Novoseek disease relationships for CXCL2 gene (see all 33 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bronchoalveolar lavage fluid	63.01	13	16046875 (1), 10358192 (1), 16424224 (1), 16002559 (1) (see all 12)
inflammation	62.62	20	11292716 (1), 11303726 (1), 10453028 (1), 18572367 (1) (see all 16)
necrosis	57.79	51	2104219 (1), 14507887 (1), 18266468 (1), 14504103 (1) (see all 48)
pneumonia	52.95	1	15320896 (1)
sepsis	41.68	12	17944017 (3), 15614130 (2), 11373406 (1), 19184349 (1) (see all 7)
tumors	35.82	66	16424980 (4), 17561115 (4), 7927176 (2), 2104219 (1) (see all 47)
peritonitis	34.59	7	15614130 (2), 11231849 (2), 11755216 (2), 11303726 (1)
infections e coli	24.72	1	10072556 (1)
pulmonary infection	23.49	1	10768990 (1)
colitis	21.66	1	18542050 (1)

About this table

Human Genome Epidemiology Navigator: CXCL2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/350 PubMed articles for CXCL2 gene (see all 350 ):

Identification of three related human GRO genes encoding cytokine functions. (PubMed id 2217207)^{1, 2, 3, 4} Haskill S.... Sager R. (1990)
Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities. (PubMed id 10725737)^{1, 3, 4} King A.G....Pelus L.M. (2000)
Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. (PubMed id 2201751)^{1, 3, 4} Tekamp-Olson P.... Cerami A. (1990)
Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. (PubMed id 2078213)^{1, 3, 4} Iida N. and Grotendorst G.R. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8. (PubMed id 10600366)^{3, 4} Qian Y.Q.... McDevitt P. (1999)
Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair. (PubMed id 2341726)^{3, 4} Sporn S.A.... Haskill S. (1990)
Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes. (PubMed id 9260277)^{1, 3} Jerva L.F....Lolis E. (1997)
Expression of growth-regulated oncogene beta in an endometrial epithelial cell line, HHUA, and cultured human endometrial cells. (PubMed id 12892904)^{1, 3} Fukuda J....Miyakawa I. (2003)
The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. (PubMed id 8702798)^{1, 3} Ahuja S.K. and Murphy P.M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2920	HGNC: 4603	AceView: CXCL2	Ensembl:ENSG00000081041	euGenes: HUgn2920
ECgene: CXCL2	H-InvDB: CXCL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CXCL2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CXCL2

Licensable Technologies for CXCL2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CXCL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CXCL2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CXCL2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CXCL2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CXCL2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GRO beta)
	Antibodies (GRO beta)

Search OriGene for CXCL2

Search Tocris compounds for CXCL2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for CXCL2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CXCL2 Gene at Home site.
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CXCL2 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for CXCL2

Summaries
for CXCL2

Genomic Location
for CXCL2

Proteins
for CXCL2

Protein Domains/
Families
for CXCL2

Gene Function
for CXCL2

Pathways & Interactions
for CXCL2

Drugs & Compounds
for CXCL2

Transcripts
for CXCL2

Expression
for CXCL2

Orthologs
for CXCL2

Paralogs
for CXCL2

SNPs/Variants
for CXCL2

Disorders & Mutations
for CXCL2

Medical News
for CXCL2

Publications
for CXCL2

Search for CXCL2

Genome Databases showing CXCL2

Other Databases showing CXCL2

Specialized Databases showing CXCL2

Licensable Technologies
for CXCL2

Services
for CXCL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CXCL2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor CXCL2

Summariesfor CXCL2

Genomic Locationfor CXCL2

Proteinsfor CXCL2

Protein Domains/Familiesfor CXCL2

Gene Functionfor CXCL2

Pathways & Interactionsfor CXCL2

Drugs & Compoundsfor CXCL2

Transcriptsfor CXCL2

Expression for CXCL2

Orthologsfor CXCL2

Paralogsfor CXCL2

SNPs/Variantsfor CXCL2

Disorders & Mutationsfor CXCL2

Medical Newsfor CXCL2

Publicationsfor CXCL2

Search for CXCL2

Genome Databases showing CXCL2

Other Databases showing CXCL2

Specialized Databases showing CXCL2

Licensable Technologiesfor CXCL2

Servicesfor CXCL2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CXCL2

Summaries
for CXCL2

Genomic Location
for CXCL2

Proteins
for CXCL2

Protein Domains/
Families
for CXCL2

Gene Function
for CXCL2

Pathways & Interactions
for CXCL2

Drugs & Compounds
for CXCL2

Transcripts
for CXCL2

Expression
for CXCL2

Orthologs
for CXCL2

Paralogs
for CXCL2

SNPs/Variants
for CXCL2

Disorders & Mutations
for CXCL2

Medical News
for CXCL2

Publications
for CXCL2

Licensable Technologies
for CXCL2

Services
for CXCL2