Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRN Gene

protein-coding   GIFtS: 69
GCID: GC17P042422

Granulin

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
granulin1 2     PGRN2
progranulin1 2     acrogranin2
PEPI2 3     granulin-epithelin2
CLN112     granulins2
GEP2     PC Cell-Derived Growth Factor2
GP882     proepithelin2
PCDGF2     Proepithelin3

External Ids:    HGNC: 46011   Entrez Gene: 28962   Ensembl: ENSG000000305827   OMIM: 1389455   UniProtKB: P287993   

Export aliases for GRN gene to outside databases

Previous GC identifers: GC17P042164 GC17P044599 GC17P042433 GC17P042897 GC17P039778 GC17P038189


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRN Gene:
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with
7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein,
progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide
produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller
cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with
granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However,
different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell
growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. (provided
by RefSeq, Jul 2008)

GeneCards Summary for GRN Gene: 
GRN (granulin) is a protein-coding gene. Diseases associated with GRN include frontotemporal lobar degeneration with ubiquitin-positive inclusions, and primary progressive aphasia. GO annotations related to this gene include growth factor activity and cytokine activity.

UniProtKB/Swiss-Prot: GRN_HUMAN, P28799
Function: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and
tissue remodeling
Function: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as
an antagonist to granulin-4, inhibiting the growth

Gene Wiki entry for GRN (Granulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRN gene promoter:
         GR   C/EBPbeta   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRN promoter sequence
   Search SABiosciences Chromatin IP Primers for GRN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.32

GRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRN gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P042422:  view genomic region     (about GC identifiers)

Start:
42,422,491 bp from pter      End:
42,430,470 bp from pter
Size:
7,980 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRN_HUMAN, P28799 (See protein sequence)
Recommended Name: Granulins precursor  
Size: 593 amino acids; 63544 Da
Subcellular location: Secreted
5 PDB 3D structures from and Proteopedia for GRN:
1G26 (3D)        2JYE (3D)        2JYT (3D)        2JYU (3D)        2JYV (3D)    
Secondary accessions: D3DX55 P23781 P23782 P23783 P23784 Q53Y88 Q540U8 Q9BWE7 Q9UCH0
Alternative splicing: 2 isoforms:  P28799-1   P28799-2   

Explore the universe of human proteins at neXtProt for GRN: NX_P28799

Explore proteomics data for GRN at MOPED 

Post-translational modifications:

  • UniProtKB: Granulins are disulfide bridged
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28799

  • GRN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRN Protein Expression
    REFSEQ proteins: NP_002078.1  
    ENSEMBL proteins: 
     ENSP00000466956   ENSP00000466271   ENSP00000465518   ENSP00000053867   ENSP00000465375  
     ENSP00000466405   ENSP00000467745   ENSP00000467022   ENSP00000467870   ENSP00000467431  
     ENSP00000466611   ENSP00000467616   ENSP00000468318   ENSP00000465673   ENSP00000467837  

    Human Recombinant Protein Products for GRN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for GRN (Progranulin/PGRN)
    Enzo Life Sciences proteins for GRN
    OriGene Purified Protein for GRN
    OriGene Protein Over-expression Lysate for GRN
    OriGene MassSpec for GRN 
    OriGene Custom Protein Services for GRN
    GenScript Custom Purified and Recombinant Proteins Services for GRN
    Novus Biologicals GRN Proteins
    Novus Biologicals GRN Lysates
    Sino Biological Recombinant Protein for GRN
    Sino Biological Cell Lysate for GRN 
    ProSpec Recombinant Protein for GRN
    Cloud-Clone Corp. Proteins for GRN 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005739mitochondrion IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    GRN for ontologies           About GeneDecksing



    GRN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for GRN (Progranulin/PGRN)
    OriGene Antibodies for GRN
    OriGene Custom Antibody Services for GRN
    GenScript Custom Superior Antibodies Services for GRN
    Novus Biologicals GRN Antibodies
    Abcam antibodies for GRN
    Cloud-Clone Corp. Antibodies for GRN 
    ThermoFisher Antibody for GRN
    LSBio Antibodies in human, mouse, rat for GRN 

    Assay Products for GRN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRN
    R&D Systems Flow Cytometry Kits for GRN (Progranulin/PGRN)         (see all)
    GenScript Custom Assay Services for GRN
    Enzo Life Sciences assays for GRN
    Cloud-Clone Corp. ELISAs for GRN 
    Cloud-Clone Corp. CLIAs for GRN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000118 Granulin
     IPR006150 Cys_repeat_1

    Graphical View of Domain Structure for InterPro Entry P28799

    ProtoNet protein and cluster: P28799

    1 Blocks protein domain: IPB000118 Granulin

    UniProtKB/Swiss-Prot: GRN_HUMAN, P28799
    Similarity: Belongs to the granulin family


    GRN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRN_HUMAN, P28799
    Function: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and
    tissue remodeling
    Function: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as
    an antagonist to granulin-4, inhibiting the growth

         Genatlas biochemistry entry for GRN:
    granulin,cysteine rich protein with growth modulatory activity,expressed by many epithelial cells,overexpressed in
    adrenal carcinoma

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding IPI--
    GO:0008083growth factor activity TAS1542665
         
    GRN for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Grn):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  nervous system  no phenotypic analysis  pigmentation 
     reproductive system 

    GRN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRN: Grntm1.1Geno Grntm1Mni Grntm1.1Aidi Grntm1.1Far

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRN:
    hsa-mir-659 (MIRT000034), hsa-mir-29b (MIRT005486), hsa-mir-107 (MIRT004761)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRN
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GRN:
    hsa-miR-588
    SwitchGear 3'UTR luciferase reporter plasmidGRN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRN
    Sirion Biotech Customized adenovirus for overexpression of GRN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GRN (see all 8)
    OriGene ORF clones in mouse, rat for GRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRN (NM_002087)
    Sino Biological Human cDNA Clone for GRN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRN
    Sirion Biotech Customized lentivirus for stable overexpression of GRN 
                         Customized lentivirus expression plasmids for stable overexpression of GRN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRN
    Search LifeMap BioReagents cell lines for GRN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for GRN
        Integrated Breast Cancer Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for GRN (P287991, 2, 3 ENSP000000538674) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPG2P981602, 3, ENSP000003638274MINT-14457 MINT-14455 MINT-14456 I2D: score=3 STRING: ENSP00000363827
    ATN1P542592, 3, ENSP000003490764MINT-2859319 MINT-2859338 I2D: score=3 STRING: ENSP00000349076
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2859357 I2D: score=3 STRING: ENSP00000344782
    SMAD9O151982, 3MINT-62094 I2D: score=3 
    CACNA1AO005551, 3EBI-747754,EBI-766279 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001835blastocyst hatching IEA--
    GO:0007165signal transduction NAS1542665
    GO:0007566embryo implantation IEA--
    GO:0008219cell death IEA--
    GO:0050679positive regulation of epithelial cell proliferation IEA--

    GRN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GRN

    7 Novoseek inferred chemical compound relationships for GRN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 17.5 7 1452336 (1), 20028451 (1), 12931033 (1), 9771457 (1) (see all 6)
    tamoxifen 3.71 3 14996734 (1), 15117809 (1), 11134521 (1)
    estradiol 0.791 5 10066447 (2), 18195084 (1)
    glucose 0 5 19056610 (1)
    agar 0 2 16533762 (2)
    estrogen 0 23 17686309 (6), 11134521 (3), 10760271 (1)
    vegf 0 19 18706200 (4), 16536983 (3), 15117809 (1)

    Search CenterWatch for drugs/clinical trials and news about GRN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRN gene (2 alternative transcripts): 
    NM_002087.2  NM_001012479.1  

    Unigene Cluster for GRN:

    Granulin
    Hs.514220  [show with all ESTs]
    Unigene Representative Sequence: NM_002087
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000588170 ENST00000589536 ENST00000587109 ENST00000587518 ENST00000053867(uc002igp.1)
    ENST00000588143 ENST00000593167 ENST00000585512 ENST00000592323 ENST00000591740
    ENST00000592783 ENST00000587387 ENST00000588237 ENST00000589265 ENST00000587958
    ENST00000586782 ENST00000590984 ENST00000586443

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRN
    1 QIAGEN miScript miRNA Assays for microRNA that regulate GRN:
    hsa-miR-588
    SwitchGear 3'UTR luciferase reporter plasmidGRN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRN
    Clone
    Products:
         
    OriGene clones in human, mouse for GRN (see all 8)
    OriGene ORF clones in mouse, rat for GRN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRN (NM_002087)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRN
    Sirion Biotech Customized lentivirus for stable overexpression of GRN 
                         Customized lentivirus expression plasmids for stable overexpression of GRN 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GRN
    OriGene qSTAR qPCR primer pairs in human, mouse for GRN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRN

    Additional mRNA sequence: 

    AF055008.1 AK000607.1 AK023348.1 AK222522.1 AK296090.1 AK303830.1 AY124489.1 BC000324.2 
    BC010577.2 BC127696.1 BT006844.1 M75161.1 X62320.1 

    24/97 DOTS entries (see all 97):

    DT.92465375  DT.119530  DT.91964486  DT.95152910  DT.100765373  DT.100847292  DT.92465366  DT.120984456 
    DT.95307573  DT.92034635  DT.120984662  DT.100697319  DT.120984626  DT.120984469  DT.120984517  DT.120984399 
    DT.120984525  DT.100697317  DT.120984378  DT.91818871  DT.120984683  DT.97866450  DT.91956205  DT.95252781 

    24/1630 AceView cDNA sequences (see all 1630):

    BU167878 BM764641 BX380909 BQ058416 CB142113 BU553504 BX360451 CB155480 
    CA435865 BI050144 BM747329 BQ681528 BM839437 BQ922685 BM742442 BM767598 
    BM926531 BM759040 BQ679882 BM767641 BP338911 BQ682607 BQ707844 BQ671033 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for GRN (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^
    SP1:                          -     -                                   -     -     -                                               -                       -   
    SP2:                          -     -                                   -     -     -                                               -                       -   
    SP3:                                                                    -     -     -                             -     -     -     -     -                 -   
    SP4:                          -     -           -     -     -     -     -     -     -     -     -     -     -     -     -           -                       -   
    SP5:                                -                                   -     -     -                                                                           

    ExUns: 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                                      
    SP2:                    -     -     -     -               
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for GRN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRN expression in normal human tissues (normalized intensities)      GRN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGTGGGG
    GRN Expression
    About this image


    GRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
             Trophoblast
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived mesenchymal stem/progenitor cells
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem/progenitor cells
     
     Mesenchymal Stem Cells
             Umbilical cord blood-derived mesenchymal stem/progenitor cells

    See GRN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRN

    SOURCE GeneReport for Unigene cluster: Hs.514220

    UniProtKB/Swiss-Prot: GRN_HUMAN, P28799
    Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage,
    in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow.
    Highest levels in kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including GRN: 
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GRN
    OriGene qSTAR qPCR primer pairs in human, mouse for GRN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRN gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grn1 , 5 granulin1, 5 78.72(n)1
    75.72(a)1
      11 (66.29 cM)5
    148241  NM_008175.41  NP_032201.21 
     1024303155 
    lizard
    (Anolis carolinensis)
    Reptilia GRN6
    Uncharacterized protein
    42(a)
    1 ↔ 1
    6(64130924-64157962)
    African clawed frog
    (Xenopus laevis)
    Amphibia grn-prov2 granulin 75.93(n)    BC048224.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj14b082 Danio rerio progranulin-b mRNA, complete cds 77.33(n)    AY289606.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T22H2.6b3   -- 54(a)
    (best of 2)
      I(11709685-11711597)   --


    ENSEMBL Gene Tree for GRN (if available)
    TreeFam Gene Tree for GRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/388 SNPs in GRN are shown (see all 388)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0444514
    Ubiquitin-positive frontotemporal dementia (UP-FTD)4--see VAR_0444512 A D mis40--------
    rs637510061,2
    Cpathogenic142426534(+) GACCAC/TGTGGA 2 T M mis10--------
    rs637503311,2
    Cpathogenic142426535(+) ACCATA/GTGGAC 2 I M mis10--------
    rs637512431,2
    Cpathogenic142426558(+) GGTGGA/CCTTAA 2 D A mis10--------
    rs637500771,2
    Cpathogenic142427619(+) CCATCC/TAGTGC 2 Q * stg10--------
    rs637512941,2
    Cpathogenic142429772(+) AGGCTC/TGATCC 2 R * stg10--------
    rs637507231,2,4
    C,Funtested142426587(+) GAACGC/TGGTGC 2 R W mis12Minor allele frequency- T:0.02WA NA 4666
    rs637507421,2
    C,Funtested142426631(+) CTGGAC/TCCCGG 2 D syn12Minor allele frequency- T:0.00NA EU 5809
    rs637500431,2
    Cuntested142427605(+) CAACTC/ACGTGG 2 /Y /S mis11Minor allele frequency- A:0.00EU 1323
    rs256461,2
    C,F,Huntested142427630(+) CCTGAT/CAGTCA 2 /D syn121Minor allele frequency- C:0.09MN NS EA NA EU 9381

    HapMap Linkage Disequilibrium report for GRN (42422491 - 42430470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GRN:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3176n71CNV Loss21882294
    dgv3175n71CNV Loss21882294
    nsv908270CNV Loss21882294


    Human Gene Mutation Database (HGMD): GRN

    Locus Specific Mutation Databases (LSDB): GRN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GRN
    DNA2.0 Custom Variant and Variant Library Synthesis for GRN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138945   
    OMIM disorders: 607485  
    UniProtKB/Swiss-Prot: GRN_HUMAN, P28799
  • Ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]: Frontotemporal dementia (FTD) is the
    second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant
    neurodegenerative disease. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Neuronal ceroid lipofuscinosis 11 (CLN11) [MIM:614706]: A form of neuronal ceroid lipofuscinosis
    characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and
    cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive
    neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent
    liposomal material. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/72 diseases for GRN (see all 72):    About MalaCards
    frontotemporal lobar degeneration with ubiquitin-positive inclusions    primary progressive aphasia    impulse control disorder    amusia
    cln11 disease    grn-related frontotemporal dementia    aphasia    amyotrophic lateral sclerosis with frontotemporal dementia
    semantic dementia    perry syndrome    frontotemporal dementia    adrenal carcinoma
    tauopathy    dementia    lewy body dementia    blastoma
    estrogen-receptor negative breast cancer    motor neuron disease    teratoma    lateral sclerosis

    6 diseases from the University of Copenhagen DISEASES database for GRN:
    Frontotemporal dementia     Aphasia     Neurodegenerative disease     Progressive supranuclear palsy
    Apraxia     Amusia

    GRN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/31 Novoseek inferred disease relationships for GRN gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    frontotemporal dementia 96 120 17698705 (5), 20087814 (4), 17984093 (2), 18543312 (2) (see all 71)
    aphasia primary progressive 88.3 2 17210807 (1), 20479359 (1)
    semantic dementia 82.9 1 20400120 (1)
    motor neuron disease 78.6 6 18183624 (1), 18802798 (1), 17360763 (1), 17969346 (1) (see all 6)
    progressive nonfluent aphasia 74.2 1 20400120 (1)
    tauopathies 73.8 2 18802798 (1), 18596549 (1)
    neuropathology 68.7 4 20026663 (1), 17458552 (1), 18715271 (1), 18723524 (1)
    parkinsonism 68 4 17030535 (1), 17969346 (1), 19938685 (1), 17659186 (1)
    dementia 67.3 15 18955727 (5), 17210804 (1), 17969346 (1), 17371905 (1) (see all 9)
    aphasia 65.3 1 20400120 (1)

    GeneTests: GRN
    GeneReviews: GRN
    Genetic Association Database (GAD): GRN
    Human Genome Epidemiology (HuGE) Navigator: GRN (47 documents)

    Export disorders for GRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRN gene, integrated from 9 sources (see all 321):
    (articles sorted by number of sources associating them with GRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosomal location of the human granulin gene. (PubMed id 1417868)1, 2, 3, 9 Bhandari V. and Bateman A. (1992)
    2. Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. (PubMed id 19158106)1, 4, 9 Finch N....Rademakers R. (2009)
    3. Brain progranulin expression in GRN-associated fronto temporal lobar degeneration. (PubMed id 19649643)1, 4, 9 Chen-Plotkin A.S....Lee V.M. (2010)
    4. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. (PubMed id 18723524)1, 4, 9 Rademakers R....Dickson D.W. (2008)
    5. Rs5848 variant influences GRN mRNA levels in brain an d peripheral mononuclear cells in patients with Alzheimer's disease. (PubMed id 19625741)1, 4, 9 Fenoglio C....Scarpini E. (2009)
    6. Granulins, a novel class of peptide from leukocytes. (PubMed id 2268320)1, 2, 9 Bateman A.... Solomon S. (1990)
    7. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. (PubMed id 17826340)1, 4, 9 Rademakers R....Hutton M. (2007)
    8. Common variant in GRN is a genetic risk factor for hi ppocampal sclerosis in the elderly. (PubMed id 20197700)1, 4, 9 Dickson D.W....Rademakers R. (2010)
    9. GRN variability contributes to sporadic frontotempora l lobar degeneration. (PubMed id 20061636)1, 4, 9 Galimberti D....Scarpini E. (2010)
    10. Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. (PubMed id 18183624)1, 2, 9 Mukherjee O.... Goate A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2896 HGNC: 4601 AceView: GRN Ensembl:ENSG00000030582 euGenes: HUgn2896
    ECgene: GRN H-InvDB: GRN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GRN Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GRN

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRN gene:
    Search GeneIP for patents involving GRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for GRN (Progranulin/PGRN)   Browse Cell Culture Products  
     ELISAs for GRN (Progranulin/PGRN)   Flow Cytometry Kits for GRN (Progranulin/PGRN)  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for GRN (Progranulin/PGRN)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for GRN (Progranulin/PGRN)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GRN   OriGene RNAi products in human, mouse, rat for GRN  
     OriGene qPCR primer pairs and template standards for GRN   OriGene Protein Over-expression Lysate for GRN  
     OriGene MassSpec something-or-other for GRN   OriGene clones in human, mouse for GRN  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRN   OriGene Purified Protein for GRN  
     OriGene ORF clones in mouse, rat for GRN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRN   OriGene Custom Protein Services for GRN  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRN
     QIAGEN SeqTarget long-range PCR primers for resequencing GRN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRN
     GenScript Custom Purified and Recombinant Proteins Services for GRN GenScript cDNA clones with any tag delivered in your preferred vector for GRN
     GenScript Custom Assay Services for GRN GenScript Custom Superior Antibodies Services for GRN
     GenScript Custom overexpressing Cell Line Services for GRN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GRN promoter
     Search Chromatin IP Primers for GRN
     RT2 qPCR Primer Assay in human, mouse, rat GRN
     GNC Network for GRN
     SABiosciences PCR Arrays including human, mouse, rat GRN
     Search Tocris compounds for GRN
     Proteins and Antibodies for GRN
     Cell Lysates for GRN
     cDNA Clones for GRN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for GRN
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GRN antibodies
     GRN proteins
     GRN lysates
     Antibodies for GRN
     See all of Abcam's Antibodies, Kits and Proteins for GRN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for GRN




     Proteins for GRN
     Antibodies for GRN
     ELISAs for GRN
     CLIAs for GRN
     Search LifeMap BioReagents cell lines for GRN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRN
     SwitchGear 3'UTR luciferase reporter plasmids for GRN
     SwitchGear Promoter luciferase reporter plasmids for GRN
     ThermoFisher Antibody for GRN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GRN
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRN
    Customized:
     lentivirus for stable overexpression of GRN
     lentivirus expression plasmids for stable overexpression of GRN
     adenovirus for overexpression of GRN
     LSBio Antibodies in human, mouse, rat for GRN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRN gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4