GRN Gene
protein-coding GIFtS: 66
GCID: GC17P042422
|
|
granulin
| |
Aliases
for GRN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Granulin1 | | Acrogranin1 | | CLN111 2 | | Granulin-Epithelin1 | | PCDGF1 2 | | Granulins1 | | PGRN1 2 | | PC Cell-Derived Growth Factor2 | | PEPI2 3 | | Proepithelin3 | | GEP2 | | Progranulin1 | | GP882 | | Proepithelin3 |
Export aliases for GRN gene to outside databasesPrevious GC identifers: GC17P042164 GC17P044599 GC17P042433 GC17P042897 GC17P039778 GC17P038189 |
Summaries
for GRN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRN:
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is alsocalled proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin whichcan be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A,granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptidesand intact granulin protein regulate cell growth. However, different members of the granulin protein family may act asinhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normaldevelopment, wound healing, and tumorigenesis. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GRN_HUMAN, P28799Function: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, andtissue remodelingFunction: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as anantagonist to granulin-4, inhibiting the growth
Gene Wiki entry for GRN (Granulin)
|
Genomic Views
for GRN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRN gene promoter:
GR C/EBPbeta GR-beta GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.32GRN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P042422: view genomic region
(about GC identifiers)
Start:
|
42,422,491 bp from pter |
End:
|
42,430,470 bp from pter |
Size:
|
7,980 bases |
Orientation:
|
plus strand |
|
Proteins
for GRN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRN_HUMAN, P28799 (See
protein sequence)Recommended Name: Granulins precursor Size: 593 amino acids; 63544 Da
Subcellular location: Secreted
5 PDB 3D structures from  and Proteopedia  for GRN:1G26 (3D)
2JYE (3D)
2JYT (3D)
2JYU (3D)
2JYV (3D)
Secondary accessions: D3DX55 P23781 P23782 P23783 P23784 Q53Y88 Q540U8 Q9BWE7 Q9UCH0Alternative splicing: 2 isoforms: P28799-1 P28799-2 Explore the universe of human proteins at neXtProt for GRN: NX_P28799
Post-translational modifications:
Granulins are disulfide bridged1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P28799
GRN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002078.1
ENSEMBL proteins: ENSP00000466956 ENSP00000466271 ENSP00000465518 ENSP00000053867 ENSP00000465375 ENSP00000466405 ENSP00000467745 ENSP00000467022 ENSP00000467870 ENSP00000467431 ENSP00000466611 ENSP00000467616 ENSP00000468318 ENSP00000465673 ENSP00000467837
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- | | GO:0005739 | mitochondrion |
IEA | -- | | GO:0043231 | intracellular membrane-bounded organelle |
IDA | -- |
GRN for ontologies About GeneDecksing
GRN Antibody Products:
Assay Products for GRN: |
Protein
Domains /
Families
for GRN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRN for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P28799ProtoNet protein and cluster: P28799 1 Blocks protein family: IPB000118 Granulin
UniProtKB/Swiss-Prot: GRN_HUMAN, P28799Similarity: Belongs to the granulin family |
Function
for GRN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GRN_HUMAN, P28799Function: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, andtissue remodelingFunction: Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as anantagonist to granulin-4, inhibiting the growth Genatlas biochemistry entry for GRN:granulin,cysteine rich protein with growth modulatory activity,expressed by many epithelial cells,overexpressed inadrenal carcinoma
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GRN (NM_002087) | |  | Sino Biological Human cDNA Clone for GRN | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRN |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
GRN for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for GRN: Grntm1.1Geno Grntm1Mni Grntm1.1Aidi Grntm1.1Far
11 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Grn):
GRN for phenotypes About GeneDecksing
|
Pathways & Interactions
for GRN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Integrated Breast Cancer Pathway | |
1  BioSystems Pathway for GRN
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRN
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/47 Interacting proteins for GRN (P287991, 2, 3 ENSP000000538674) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
GRN for ontologies About GeneDecksing
|
Drugs & Compounds
for GRN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GRN for compounds About GeneDecksing
 Browse Tocris compounds for GRN
7 Novoseek chemical compound relationships for GRN gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cysteine |
17.5 |
7 |
1452336 (1), 20028451 (1), 12931033 (1), 9771457 (1) (see all 6) |
| tamoxifen |
3.71 |
3 |
14996734 (1), 15117809 (1), 11134521 (1) |
| estradiol |
0.791 |
5 |
10066447 (2), 18195084 (1) |
| glucose |
0 |
5 |
19056610 (1) |
| agar |
0 |
2 |
16533762 (2) |
| estrogen |
0 |
23 |
17686309 (6), 11134521 (3), 10760271 (1) |
| vegf |
0 |
19 |
18706200 (4), 16536983 (3), 15117809 (1) |
Search CenterWatch for drugs/clinical trials and news about GRN
|
Transcripts
for GRN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRN gene (2 alternative transcripts): NM_002087.2 NM_001012479.1 Unigene Cluster for GRN: Granulin Hs.514220 [show with all ESTs]Unigene Representative Sequence: NM_00208718/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000588170 ENST00000589536 ENST00000587109 ENST00000587518 ENST00000053867(uc002igp.1)
ENST00000588143 ENST00000593167 ENST00000585512 ENST00000592323 ENST00000591740
ENST00000592783 ENST00000587387 ENST00000588237 ENST00000589265 ENST00000587958
ENST00000586782 ENST00000590984 ENST00000586443
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRN (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRN (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GRN (NM_002087) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRN |
Additional cDNA sequence: AF055008.1 AK000607.1 AK023348.1 AK222522.1 AK296090.1 AK303830.1 AY124489.1 BC000324.2 BC010577.2 BC127696.1 BT006844.1 M75161.1 X62320.1 24/97 DOTS entries (see all 97): DT.92465375 DT.119530 DT.91964486 DT.95152910 DT.100765373 DT.100847292 DT.92465366 DT.120984456 DT.95307573 DT.92034635 DT.120984662 DT.100697319 DT.120984626 DT.120984469 DT.120984517 DT.120984399 DT.120984525 DT.100697317 DT.120984378 DT.91818871 DT.120984683 DT.97866450 DT.91956205 DT.95252781 24/1630 AceView cDNA sequences (see all 1630): BM764814 AU279879 BU167878 BF718242 BX355624 BF876475 BM767598 AL541798 BP365301 AI597821 AK000607 BM826876 BX334776 BM767641 BQ679882 BI771292 BQ706910 BM767572 BM768024 AI299492 BU542200 CR594600 BU527444 BF219738
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for GRN (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | |
| SP4: | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | - | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GRN
|
Expression
for GRN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGGTGGGG
About this image
See GRN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRN
SOURCE GeneReport for Unigene cluster: Hs.514220
UniProtKB/Swiss-Prot: GRN_HUMAN, P28799Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, infibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levelsin kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including GRN:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRN |
Orthologs
for GRN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GRN gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Grn1 , 5 |
granulin1, 5 |
78.72(n)1
75.72(a)1 |
|
11 (66.29 cM)5
148241 NM_008175.41 NP_032201.21
1024303155 |
lizard
(Anolis carolinensis) |
Reptilia |
GRN6 |
-- |
41(a) |
1 ↔ 1 |
6(64130937-64155664) |
African clawed frog
(Xenopus laevis) |
Amphibia |
grn-prov2 |
granulin |
75.93(n) |
|
BC048224.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj14b082 |
Danio rerio progranulin-b mRNA, complete cds |
77.33(n) |
|
AY289606.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
T22H2.6b3 |
-- |
54(a)
(best of 2) |
|
I(11709685-11711597) -- |
ENSEMBL Gene Tree for GRN (if available)
TreeFam Gene Tree for GRN (if available) |
Paralogs
for GRN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GRN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRN (42422491 - 42430470 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GRN: --
Human Gene Mutation Database (HGMD): GRN
Locus Specific Mutation Databases (LSDB): GRN
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRN |
|
Disorders
/ Diseases
for GRN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRN for disorders About GeneDecksing
OMIM gene information: 138945
OMIM disorders: 607485
UniProtKB/Swiss-Prot: GRN_HUMAN, P28799
Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also knownas tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second mostcommon cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11) [MIM:614706]. A form ofneuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures,cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses areprogressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation ofautofluorescent liposomal material
20/68  diseases for GRN (see all 68): About MalaCardsfrontotemporal lobar degeneration with ubiquitin-positive inclusions grn-related frontotemporal dementia impulse control disorder estrogen-receptor negative breast cancer
frontotemporal dementia semantic dementia amyotrophic lateral sclerosis amyotrophic lateral sclerosis with frontotemporal dementia
aphasia lewy body dementia primary progressive aphasia lateral sclerosis
traumatic brain injury amusia motor neuron disease dementia
brain injury perry syndrome fatty liver disease tauopathy
6 diseases from the University of Copenhagen DISEASES database for GRN:Frontotemporal dementia Aphasia Amyotrophic lateral sclerosis Progressive supranuclear palsy
Apraxia Pick's disease 10/31 Novoseek disease relationships for GRN gene (see all 31) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| frontotemporal dementia |
96 |
120 |
17698705 (5), 20087814 (4), 17984093 (2), 18543312 (2) (see all 71) |
| aphasia primary progressive |
88.3 |
2 |
17210807 (1), 20479359 (1) |
| semantic dementia |
82.9 |
1 |
20400120 (1) |
| motor neuron disease |
78.6 |
6 |
18183624 (1), 18802798 (1), 17360763 (1), 17969346 (1) (see all 6) |
| progressive nonfluent aphasia |
74.2 |
1 |
20400120 (1) |
| tauopathies |
73.8 |
2 |
18802798 (1), 18596549 (1) |
| neuropathology |
68.7 |
4 |
20026663 (1), 17458552 (1), 18715271 (1), 18723524 (1) |
| parkinsonism |
68 |
4 |
17030535 (1), 17969346 (1), 19938685 (1), 17659186 (1) |
| dementia |
67.3 |
15 |
18955727 (5), 17210804 (1), 17969346 (1), 17371905 (1) (see all 9) |
| aphasia |
65.3 |
1 |
20400120 (1) |
GeneTests: GRN
GRN-Related Frontotemporal Dementia
Human Genome Epidemiology (HuGE) Navigator: GRN (47 documents)
Export disorders for GRN gene to outside databases
|
Publications
for GRN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRN gene, integrated from 9 sources (see all 301):
(articles sorted by number of sources associating them with GRN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and chromosomal location of the human granulin gene. (PubMed id 1417868)1, 2, 3, 9 Bhandari V. and Bateman A. (1992)
- Granulins, a novel class of peptide from leukocytes. (PubMed id 2268320)1, 2, 9 Bateman A.... Solomon S. (1990)
- Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. (PubMed id 18183624)1, 2, 9 Mukherjee O.... Goate A. (2008)
- Design and solution structure of a well-folded stack of two beta- hairpins based on the amino-terminal fragment of human granulin A. (PubMed id 10715107)1, 2, 9 Tolkatchev D.... Ni F. (2000)
- Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. (PubMed id 16862116)1, 2, 9 Baker M.... Hutton M. (2006)
- HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. (PubMed id 16983685)1, 2, 9 Mukherjee O....Goate A.M. (2006)
- Strikingly different clinicopathological phenotypes de termined by progranulin-mutation dosage. (PubMed id 22608501)1, 2 Smith K.R....Berkovic S.F. (2012)
- A thorough assessment of benign genetic variability i n GRN and MAPT. (PubMed id 20020531)1, 2 Guerreiro R.J....Singleton A. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor). (PubMed id 9826678)1, 3 Zhang H. and Serrero G. (1998)
|
External Searches for GRN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRN | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for GRN | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GRN |
|
| | |
About This Section
| Patent Information for GRN gene:
Search GeneIP for patents involving GRN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for GRN | | OriGene shRNA RFP for GRN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRN | | | OriGene Protein Over-expression Lysate for GRN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GRN | | OriGene 3'-UTR Clone for GRN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GRN | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GRN | | OriGene Custom Protein Services for GRN | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRN |
| |
 |  |  |  | |
| | | | Search Tocris compounds for GRN |
| |  |  |  |  | | | | | | Recombinant Protein for GRN |
|
 |
 |
 |
 | | | GRN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRN |
|  |  |  | | | | ThermoFisher Antibodies for GRN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRN |
|
|
|
|
