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Aliases for GRM8 Gene

Aliases for GRM8 Gene

  • Glutamate Metabotropic Receptor 8 2 3 5
  • Glutamate Receptor, Metabotropic 8 2 3
  • GPRC1H 3 4
  • MGLUR8 3 4
  • Metabotropic Glutamate Receptor 8 3
  • GLUR8 3
  • MGlu8 3

External Ids for GRM8 Gene

Previous GeneCards Identifiers for GRM8 Gene

  • GC07M124556
  • GC07M125619
  • GC07M125633
  • GC07M125609
  • GC07M125672
  • GC07M125865
  • GC07M126078
  • GC07M120439

Summaries for GRM8 Gene

Entrez Gene Summary for GRM8 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM8 Gene

GRM8 (Glutamate Metabotropic Receptor 8) is a Protein Coding gene. Diseases associated with GRM8 include Autism Spectrum Disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and group III metabotropic glutamate receptor activity. An important paralog of this gene is GRM4.

UniProtKB/Swiss-Prot for GRM8 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM8 Gene

  • Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.

Gene Wiki entry for GRM8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM8 Gene

Genomics for GRM8 Gene

Regulatory Elements for GRM8 Gene

Enhancers for GRM8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F127447 0.6 ENCODE 9.8 -194.2 -194248 0.2 CTCF CBX3 ZNF2 RAD21 FOXK2 CBX5 ZNF143 SMC3 ZNF654 TRIM22 GRM8 PAX4 GC07P127451 ZNF800
GH07F127018 1 FANTOM5 1.6 +235.0 235001 0.3 IKZF1 ZNF207 GRM8 MIR592 ENSG00000230820
GH07F127165 0.3 FANTOM5 1.4 +87.3 87291 0.1 LOC101928333 GRM8 GC07M127144
GH07F127253 1 FANTOM5 ENCODE 0.8 -0.9 -889 0.4 ZNF2 RAD21 ZNF366 SCRT2 ZNF143 ZNF654 MIER2 REST ZEB2 SMARCA4 GRM8 PRELID3BP10
GH07F127254 0.4 ENCODE 0.8 -0.7 -653 0.0 CTCF RAD21 ZNF2 ZNF664 ZBTB48 ZNF366 SCRT2 SMC3 ZNF143 ZBTB20 GRM8 PRELID3BP10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GRM8 on UCSC Golden Path with GeneCards custom track

Promoters for GRM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001895939 -6 2200 INSM2 ZNF76 ZNF2 RAD21 ZEB1 YY1 GLIS2 ZNF366 SCRT2 ZNF143

Genomic Location for GRM8 Gene

126,438,598 bp from pter
127,253,294 bp from pter
814,697 bases
Minus strand

Genomic View for GRM8 Gene

Genes around GRM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM8 Gene

Proteins for GRM8 Gene

  • Protein details for GRM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metabotropic glutamate receptor 8
    Protein Accession:
    Secondary Accessions:
    • A4D0Y3
    • B0FZ74
    • B0M0L0
    • O15493
    • O95945
    • O95946
    • Q3MIV9
    • Q52M02
    • Q6J165

    Protein attributes for GRM8 Gene

    908 amino acids
    Molecular mass:
    101741 Da
    Quaternary structure:
    • Interacts with PICK1.

    Alternative splice isoforms for GRM8 Gene


neXtProt entry for GRM8 Gene

Post-translational modifications for GRM8 Gene

  • Glycosylation at Asn 95, Asn 298, Asn 452, Asn 480, and Asn 565
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GRM8

No data available for DME Specific Peptides for GRM8 Gene

Domains & Families for GRM8 Gene

Gene Families for GRM8 Gene

Suggested Antigen Peptide Sequences for GRM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM8: view

Function for GRM8 Gene

Molecular function for GRM8 Gene

GENATLAS Biochemistry:
metabotropic glutamate receptor 8,groupe III,G protein coupled receptor superfamily, linked to the inhibition of cAMP cascade
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001642 group III metabotropic glutamate receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,IMP 9473604
GO:0008066 glutamate receptor activity IMP 9473604
genes like me logo Genes that share ontologies with GRM8: view
genes like me logo Genes that share phenotypes with GRM8: view

Animal Models for GRM8 Gene

MGI Knock Outs for GRM8:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRM8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM8 Gene

Localization for GRM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRM8 Gene COMPARTMENTS Subcellular localization image for GRM8 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 9473604
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042734 presynaptic membrane IBA --
genes like me logo Genes that share ontologies with GRM8: view

Pathways & Interactions for GRM8 Gene

genes like me logo Genes that share pathways with GRM8: view

Gene Ontology (GO) - Biological Process for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IMP 9473604
GO:0007601 visual perception TAS 9473604
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with GRM8: view

No data available for SIGNOR curated interactions for GRM8 Gene

Drugs & Compounds for GRM8 Gene

(21) Drugs for GRM8 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, antagonist, Target 0
L-AP4 Pharma Agonist Selective group III mGlu agonist 0
(<i>R,S</i>)-4-PPG Pharma Full agonist, Agonist 0
(<i>S</i>)-3,4-DCPG Pharma Full agonist, Agonist 0
(1<i>S</i>,3<i>R</i>)-ACPD Pharma Full agonist, Agonist 0

(2) Additional Compounds for GRM8 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GRM8 Gene

Compound Action Cas Number
AMN 082 dihydrochloride The first selective mGlu7 agonist 97075-46-2
CPPG Very potent group III mGlu antagonist 183364-82-1
L-AP4 Selective group III mGlu agonist 23052-81-5
MMPIP hydrochloride Potent, allosteric mGlu7-selective antagonist 479077-02-6
MSOP Specific group III mGlu antagonist 66515-29-5
genes like me logo Genes that share compounds with GRM8: view

Transcripts for GRM8 Gene

mRNA/cDNA for GRM8 Gene

Unigene Clusters for GRM8 Gene

Glutamate receptor, metabotropic 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRM8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - - -

Relevant External Links for GRM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM8 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Frontal Cortex (BA9) (x5.1), Brain - Putamen (basal ganglia) (x4.5), Brain - Caudate (basal ganglia) (x4.3), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GRM8 Gene

This gene is overexpressed in Heart (59.0) and Adipocyte (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRM8 Gene

Protein tissue co-expression partners for GRM8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRM8 Gene:


SOURCE GeneReport for Unigene cluster for GRM8 Gene:

genes like me logo Genes that share expression patterns with GRM8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GRM8 Gene

Orthologs for GRM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRM8 34
  • 99.74 (n)
(Monodelphis domestica)
Mammalia GRM8 35
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia GRM8 35
  • 96 (a)
(Canis familiaris)
Mammalia GRM8 34 35
  • 93.61 (n)
(Bos Taurus)
Mammalia GRM8 34
  • 93.06 (n)
(Mus musculus)
Mammalia Grm8 34 16 35
  • 91.7 (n)
(Rattus norvegicus)
Mammalia Grm8 34
  • 91.7 (n)
(Gallus gallus)
Aves GRM8 34 35
  • 84.05 (n)
(Anolis carolinensis)
Reptilia GRM8 35
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497088 34
  • 79.32 (n)
(Danio rerio)
Actinopterygii grm8a 35
  • 83 (a)
GRM8 (1 of 2) 35
  • 81 (a)
LOC569768 34
  • 73.01 (n)
Dr.26085 34
fruit fly
(Drosophila melanogaster)
Insecta mtt 34
  • 51.67 (n)
Glu-RA 36
  • 46 (a)
CG30361 36
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRMGL5 34
  • 50.76 (n)
(Caenorhabditis elegans)
Secernentea mgl-1 36
  • 37 (a)
mgl-3 35
  • 31 (a)
Species where no ortholog for GRM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM8 Gene

Gene Tree for GRM8 (if available)
Gene Tree for GRM8 (if available)

Paralogs for GRM8 Gene

Paralogs for GRM8 Gene

(8) SIMAP similar genes for GRM8 Gene using alignment to 4 proteins: Pseudogenes for GRM8 Gene

genes like me logo Genes that share paralogs with GRM8: view

Variants for GRM8 Gene

Sequence variations from dbSNP and Humsavar for GRM8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs139289550 Uncertain significance 126,446,249(+) CTTGC(A/G)TTTTT nc-transcript-variant, reference, missense
rs1002366 -- 126,845,222(+) ACTAT(A/G)ACTAT intron-variant
rs1002744 -- 126,847,427(-) AAAAT(A/G)AATTT intron-variant
rs1003036 -- 126,958,780(+) ATCTA(A/T)AGGGA intron-variant
rs1003037 -- 126,958,958(+) TCACA(A/G)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRM8 Gene

Variant ID Type Subtype PubMed ID
dgv1329e214 CNV loss 21293372
dgv1959e212 CNV loss 25503493
dgv3662n106 CNV deletion 24896259
esv1000131 CNV insertion 20482838
esv1000509 CNV deletion 20482838
esv1009957 CNV deletion 20482838
esv1300352 CNV deletion 17803354
esv1480862 CNV insertion 17803354
esv1733605 CNV deletion 17803354
esv2019229 CNV deletion 18987734
esv2158688 CNV deletion 18987734
esv23929 CNV loss 19812545
esv2606684 CNV deletion 19546169
esv2609252 CNV deletion 19546169
esv2622637 CNV deletion 19546169
esv26377 CNV gain+loss 19812545
esv2668105 CNV deletion 23128226
esv2670600 CNV deletion 23128226
esv2678710 CNV deletion 23128226
esv2735116 CNV deletion 23290073
esv2735118 CNV deletion 23290073
esv2735119 CNV deletion 23290073
esv2735120 CNV deletion 23290073
esv2735121 CNV deletion 23290073
esv2735122 CNV deletion 23290073
esv2735123 CNV deletion 23290073
esv2759562 CNV loss 17122850
esv2761365 CNV loss 21179565
esv2761367 CNV loss 21179565
esv27641 CNV gain 19812545
esv3347869 CNV insertion 20981092
esv3350870 CNV duplication 20981092
esv3365094 CNV insertion 20981092
esv3367822 CNV duplication 20981092
esv33690 CNV loss 17666407
esv33698 CNV loss 17666407
esv3373213 CNV insertion 20981092
esv3379634 CNV duplication 20981092
esv3410812 CNV insertion 20981092
esv3433844 CNV insertion 20981092
esv3435518 CNV insertion 20981092
esv3445328 CNV insertion 20981092
esv3542399 CNV deletion 23714750
esv3542401 CNV deletion 23714750
esv3572126 CNV loss 25503493
esv3572127 CNV loss 25503493
esv3572130 CNV loss 25503493
esv3572132 CNV loss 25503493
esv3572133 CNV loss 25503493
esv3614931 CNV loss 21293372
esv3614936 CNV loss 21293372
esv3614938 CNV loss 21293372
esv3614939 CNV gain 21293372
esv3614940 CNV loss 21293372
esv3614951 CNV loss 21293372
esv3614952 CNV loss 21293372
esv3891200 CNV loss 25118596
esv3891206 CNV loss 25118596
esv5207 CNV loss 18987735
nsv1027369 CNV gain 25217958
nsv1027558 CNV loss 25217958
nsv1032108 CNV loss 25217958
nsv1032612 CNV loss 25217958
nsv1075058 CNV deletion 25765185
nsv1075994 CNV deletion 25765185
nsv1076949 CNV deletion 25765185
nsv1129285 CNV insertion 24896259
nsv1137288 CNV deletion 24896259
nsv1143191 CNV tandem duplication 24896259
nsv1154027 CNV deletion 26484159
nsv436533 CNV deletion 17901297
nsv437572 CNV loss 16327808
nsv473619 CNV novel sequence insertion 20440878
nsv499782 CNV loss 21111241
nsv510114 OTHER sequence alteration 20534489
nsv517633 CNV loss 19592680
nsv518034 CNV loss 19592680
nsv521803 CNV gain 19592680
nsv5938 CNV insertion 18451855
nsv5939 CNV deletion 18451855
nsv5940 CNV deletion 18451855
nsv5941 CNV insertion 18451855
nsv608376 CNV loss 21841781
nsv608377 CNV loss 21841781
nsv608378 CNV loss 21841781
nsv608379 CNV loss 21841781
nsv608380 CNV loss 21841781
nsv819682 CNV gain 19587683
nsv8211 CNV loss 18304495
nsv8212 CNV loss 18304495
nsv831121 CNV gain 17160897
nsv981575 CNV duplication 23825009

Variation tolerance for GRM8 Gene

Residual Variation Intolerance Score: 6.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRM8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM8 Gene

Disorders for GRM8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRM8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search GRM8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRM8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM8 Gene

Publications for GRM8 Gene

  1. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. (PMID: 18195715) Nielsen D.A. … Kreek M.J. (Mol. Psychiatry 2008) 3 22 46 64
  2. Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. (PMID: 15211621) Takaki H. … Fukumaki Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 22 46 64
  3. No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. (PMID: 11912074) Preuss U.W. … Bondy B. (Alcohol Alcohol. 2002) 3 22 46 64
  4. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. (PMID: 10216218) Malherbe P. … Mutel V. (Brain Res. Mol. Brain Res. 1999) 3 4 22 64
  5. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (PMID: 9473604) Wu S. … Belagaje R.M. (Brain Res. Mol. Brain Res. 1998) 3 4 22 64

Products for GRM8 Gene

Sources for GRM8 Gene

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