Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GRM8 Gene

protein-coding   GIFtS: 70
GCID: GC07M126078

Glutamate Receptor, Metabotropic 8

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glutamate Receptor, Metabotropic 81 2     mGlu82
GPRC1H2 3     Metabotropic Glutamate Receptor 82
MGLUR82 3     mGluR83
GLUR82     

External Ids:    HGNC: 46001   Entrez Gene: 29182   Ensembl: ENSG000001796037   OMIM: 6011165   UniProtKB: O002223   

Export aliases for GRM8 gene to outside databases

Previous GC identifers: GC07M124556 GC07M125619 GC07M125633 GC07M125609 GC07M125672 GC07M125865 GC07M120439


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GRM8 Gene:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic
and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain
function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a
family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology,
putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes
GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but
differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have
been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRM8 Gene:
GRM8 (glutamate receptor, metabotropic 8) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and group III metabotropic glutamate receptor activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GRM8_HUMAN, O00222
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity

summary for GRM8 Gene:
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided
into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. The receptors are coupled to Gi/o which inhibits adenylyl
cyclase, decreasing the formation of cAMP. mGlu group III receptors are involved in spatial learning and
memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and
presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8
receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1)
respectively.

Gene Wiki entry for GRM8 (Metabotropic glutamate receptor 8) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRM8 gene promoter:
         SRF (504 AA)   Brachyury   HTF   Nkx2-5   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): GRM8 promoter sequence
   Search Chromatin IP Primers for GRM8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3-q32.1   Ensembl cytogenetic band:  7q31.33   HGNC cytogenetic band: 7q31.3-q32.1

GRM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM8 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M126078:  view genomic region     (about GC identifiers)

Start:
126,078,652 bp from pter      End:
126,893,348 bp from pter
Size:
814,697 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 125,461,722-126,275,858     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for GRM8

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GRM8_HUMAN, O00222 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 8 precursor  
Size: 908 amino acids; 101741 Da
Subunit: Interacts with PICK1 (By similarity)
Secondary accessions: A4D0Y3 B0FZ74 B0M0L0 O15493 O95945 O95946 Q3MIV9 Q52M02 Q6J165
Alternative splicing: 3 isoforms:  O00222-1   O00222-2   O00222-3   

Explore the universe of human proteins at neXtProt for GRM8: NX_O00222

Explore proteomics data for GRM8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn95, Asn298, Asn452, Asn480, Asn565
  • Modification sites at PhosphoSitePlus

  • See GRM8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000836.2  NP_001120795.1  

    ENSEMBL proteins: 
     ENSP00000344173   ENSP00000351142   ENSP00000345747   ENSP00000419832   ENSP00000415522  
     ENSP00000418255   ENSP00000398012   ENSP00000409790   ENSP00000385731  
    Reactome Protein details: O00222

    GRM8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRM8
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRM8
    GenScript Custom Purified and Recombinant Proteins Services for GRM8
    Novus Biologicals GRM8 Proteins
    Novus Biologicals GRM8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRM8

     
    Search eBioscience for Proteins for GRM8 

    GRM8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRM8
    R&D Systems Antibodies for GRM8 (mGluR8)
    OriGene Antibodies for GRM8
    OriGene Custom Antibody Services for GRM8
    Novus Biologicals GRM8 Antibodies
    Abcam antibodies for GRM8
    Cloud-Clone Corp. Antibodies for GRM8
    ThermoFisher Antibodies for GRM8
    LSBio Antibodies in human, mouse, rat for GRM8

    GRM8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRM8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRM8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRM8
    Cloud-Clone Corp. CLIAs for GRM8
    Search eBioscience for ELISAs for GRM8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GR: Glutamate receptors
    GRM: GPCR / Class C : Glutamate receptors, metabotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: mGlu8 receptor
    Metabotropic glutamate receptors

    Selected InterPro protein domains (see all 8):
     IPR011500 GPCR_3_9-Cys_dom
     IPR028082 Peripla_BP_I
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR000144 GPCR_3_mtglu_rcpt_8

    Graphical View of Domain Structure for InterPro Entry O00222

    ProtoNet protein and cluster: O00222

    4 Blocks protein domains:
    IPB000144 Metabotropic glutamate receptor 8 signature
    IPB000162 Metabotropic glutamate receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM8_HUMAN, O00222
    Similarity: Belongs to the G-protein coupled receptor 3 family


    Find genes that share domains with GRM8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRM8_HUMAN, O00222
    Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
    signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
    effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity

         Genatlas biochemistry entry for GRM8:
    metabotropic glutamate receptor 8,groupe III,G protein coupled receptor superfamily, linked to the inhibition of
    cAMP cascade

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001642group III metabotropic glutamate receptor activity IEA--
    GO:0004930G-protein coupled receptor activity IMP9473604
    GO:0008066glutamate receptor activity IMP9473604
         
    Find genes that share ontologies with GRM8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GRM8:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Grm8):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with GRM8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GRM8: Grm8tm1Duv Grm8tm1En

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRM8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRM8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRM8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRM8

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRM8:
    hsa-mir-26b-5p (MIRT028921)

    Block miRNA regulation of human, mouse, rat GRM8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM8 (see all 15):
    hsa-miR-3149 hsa-miR-3163 hsa-miR-300 hsa-miR-381 hsa-miR-885-5p hsa-miR-3157-5p hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidGRM8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRM8
    Predesigned siRNA for gene silencing in human, mouse, rat GRM8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRM8

    Clone
    Products:
         
    OriGene clones in human, mouse for GRM8 (see all 13)
    OriGene ORF clones in mouse, rat for GRM8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRM8 (NM_000845)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRM8
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRM8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GRM8_HUMAN, O00222: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9473604
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with GRM8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GRM8 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Glutamic acid signaling
    Glutamic acid signaling
    Synaptic Neurotransmission: Glutamatergic Excitation0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    CREB Pathway0.68
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47


    Find genes that share SuperPaths with GRM8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GRM8
        Synaptic Neurotransmission: Glutamatergic Excitation

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRM8
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Signaling in Gap Junctions

    2 BioSystems Pathways for GRM8
        GPCRs, Other
    GPCRs, Class C Metabotropic glutamate, pheromone

    2 Reactome Pathways for GRM8
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for GRM8):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM8: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRM8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for GRM8 (O002223 ENSP000003441734) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    PIAS1O759253, ENSP000002496364I2D: score=1 STRING: ENSP00000249636
    RANBP9Q96S593, ENSP000000116194I2D: score=1 STRING: ENSP00000011619
    PIAS2O759283, ENSP000003816484I2D: score=1 STRING: ENSP00000381648
    FLNAP213333, ENSP000003588664I2D: score=1 STRING: ENSP00000358866
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IMP9473604
    GO:0007601visual perception TAS9473604
    GO:0007608sensory perception of smell IEA--
    GO:0030818negative regulation of cAMP biosynthetic process IDA11166323

    Find genes that share ontologies with GRM8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GRM8
      Browse compounds at ApexBio 

    Compounds for GRM8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MSOPSpecific group III mGlu antagonist[66515-29-5]
    L-AP4Selective group III mGlu agonist[23052-81-5]
    (S)-3,4-DCPG Potent, selective mGlu8a agonist [201730-11-2]
    AMN 082 dihydrochlorideThe first selective mGlu7 agonist[97075-46-2]
    CPPGVery potent group III mGlu antagonist[183364-82-1]

    1 HMDB Compound for GRM8    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--

    1 DrugBank Compound for GRM8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17360958 16957773

    Selected IUPHAR Ligands for GRM8 (mGlu8 receptor) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    (S)-3,4-DCPG
    AgonistFull agonist7.511166323
    L-AP4
    AgonistFull agonist7 - 7.210216218
    L-SOP
    AgonistFull agonist6.2 - 7.210216218 9473604
    LY341495
    AntagonistAntagonist6.89680254
    (R,S)-4-PPG
    AgonistFull agonist6.711166323 10336568 10866390
    [3H]AP4
    AgonistFull agonist6.6 - 6.710216218
    L-CCG-I
    AgonistFull agonist6.1 - 6.310216218
    AZ12216052
    Allosteric regulatorPositive620385173
    L-glutamic acid
    AgonistFull agonist5 - 5.710216218 9473604
    DCG-IV
    AntagonistAntagonist5.510216218

    3 Novoseek inferred chemical compound relationships for GRM8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 70.7 18 10216218 (2), 11027680 (2), 12676915 (1), 15211621 (1) (see all 14)
    kainate 42.4 1 10515165 (1)
    nmda 10.5 2 10515165 (1)



    Find genes that share compounds with GRM8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GRM8 gene (2 alternative transcripts): 
    NM_000845.2  NM_001127323.1  

    Unigene Cluster for GRM8:

    Glutamate receptor, metabotropic 8
    Hs.449625  [show with all ESTs]
    Unigene Representative Sequence: NM_001127323
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339582(uc010lkz.1) ENST00000358373(uc011kof.1 uc003vlt.2)
    ENST00000489939 ENST00000341617 ENST00000495315 ENST00000472701 ENST00000480995(uc003vlu.1)
    ENST00000448250 ENST00000457830 ENST00000465844 ENST00000423518 ENST00000465800
    ENST00000473254 ENST00000412160 ENST00000444921(uc003vls.2 uc003vlr.2)
    ENST00000405249
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GRM8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM8 (see all 15):
    hsa-miR-3149 hsa-miR-3163 hsa-miR-300 hsa-miR-381 hsa-miR-885-5p hsa-miR-3157-5p hsa-miR-1305 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidGRM8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GRM8
    Predesigned siRNA for gene silencing in human, mouse, rat GRM8
    Clone
    Products:
         
    OriGene clones in human, mouse for GRM8 (see all 13)
    OriGene ORF clones in mouse, rat for GRM8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRM8 (NM_000845)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GRM8
    OriGene qSTAR qPCR primer pairs in human, mouse for GRM8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRM8
      QuantiTect SYBR Green Assays in human, mouse, rat GRM8
      QuantiFast Probe-based Assays in human, mouse, rat GRM8

    Additional mRNA sequence: 

    AJ236921.1 AJ236922.1 AK123053.1 AK290197.1 AK315203.1 AY608335.1 BC093725.1 BC101675.1 
    BC143344.1 EU432125.1 NR_028041.1 U92459.1 U95025.1 

    7 DOTS entries:

    DT.107886  DT.95261639  DT.100742971  DT.91753584  DT.95126498  DT.404800  DT.96085324 

    11 AceView cDNA sequences:

    BV181616 BV196443 BG722120 AK123053 AA922190 AA926703 U95025 AA931601 
    AY608335 U92459 NM_000845 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for GRM8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:              -           -                                                     -               
    SP2:              -           -                             -                       -               
    SP3:              -           -                             -                                       
    SP4:                                                                                                


    ECgene alternative splicing isoforms for GRM8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GRM8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTTTTTA
    GRM8 Expression
    About this image


    GRM8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Midbrain dopaminergic-like neurons
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Neurons
             Midbrain dopaminergic-like neurons
     
     Colon (Gastrointestinal Tract)
    GRM8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRM8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449625
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM8: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for GRM8
    OriGene qSTAR qPCR primer pairs in human, mouse for GRM8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRM8
    QuantiTect SYBR Green Assays in human, mouse, rat GRM8
    QuantiFast Probe-based Assays in human, mouse, rat GRM8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GRM8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grm81 , 5 glutamate receptor, metabotropic 81, 5 91.7(n)1
    98.1(a)1
      6 (11.97 cM)5
    148231  NM_008174.21  NP_032200.21 
     272751215 
    chicken
    (Gallus gallus)
    Aves GRM81 glutamate receptor, metabotropic 8 84.05(n)
    94.16(a)
      427853  XM_425426.4  XP_425426.3 
    lizard
    (Anolis carolinensis)
    Reptilia GRM86
    glutamate receptor, metabotropic 8
    91(a)
    1 ↔ 1
    5(65516837-65847249)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004970881 metabotropic glutamate receptor 8-like 79.32(n)
    90.68(a)
      100497088  XM_004912995.1  XP_004913052.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.260852 Transcribed sequence with moderate similarity to protein more 80.8(n)    CD604414.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glu-RA3
    mtt1
    metabotropic glutamate receptor
    signaling pathway more3
    mangetout1
    46(a)
    (best of 2)3
    51.67(n)1
    45.7(a)1
      358321  NM_136542.31  NP_610386.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mgl-13 metatrophic glutamate receptor 37(a)   X(10003865-10009638)   --


    ENSEMBL Gene Tree for GRM8 (if available)
    TreeFam Gene Tree for GRM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GRM8 gene
    GRM72  GRM42  TAS1R22  TAS1R32  GRM22  GRM32  TAS1R12  GRM62  
    GRM52  GRM12  GPRC6A2  
    8 SIMAP similar genes for GRM8 using alignment to 4 protein entries:     GRM8_HUMAN (see all proteins):
    GRM7    GRM4    GRM6    GRM3    GRM2    GRM5
    GRM1    CASR

    Find genes that share paralogs with GRM8           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for GRM8
    PGOHUM00000233381


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GRM8 (see all 16237)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392895501,2
    Cuntested1129430272(+) CTTGCG/ATTTTT 5 /R /C mis11Minor allele frequency- A:0.00NA 4548
    rs127067361,2
    C,F--120563744(+) TTTTTT/AAAAAA 3 -- int15Minor allele frequency- A:0.50NA WA 10
    rs714617961,2
    C--120632508(-) TTTGT-/GTT   
      T
    /TTGT
    TTTTG
    3 -- int11NA 2
    rs768023061,2
    C--120632613(+) GGAACT/ATAAAT 3 -- int13Minor allele frequency- A:0.00NA 8
    rs2005255981,2
    C--120729395(+) ACTCTC/TTTTCT 3 -- int10--------
    rs346764941,2
    C--120751686(+) AAAAA-/AGAAAA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs350773631,2
    C--120924429(+) AGATT-/CCATTA 3 -- int12Minor allele frequency- C:0.25NA 4
    rs770453791,2
    C--120965644(-) TGTCCT/ATGTAT 3 -- int13Minor allele frequency- A:0.12NA 8
    rs677641401,2
    C--121060190(+) TTTGC-/TTTTTT 3 -- int10--------
    rs359655021,2
    C,F--121070346(+) AATTT-/AAAAAA 3 -- int13Minor allele frequency- A:0.50NA CSA 6

    HapMap Linkage Disequilibrium report for GRM8 (126078652 - 126328652 bp, first 250kb of GRM8)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRM8 (see all 52):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735123CNV Deletion23290073
    esv2668105CNV Deletion23128226
    esv5207CNV Deletion18987735
    esv1009957CNV Deletion20482838
    esv2735121CNV Deletion23290073
    esv2609252CNV Deletion19546169
    esv2678710CNV Deletion23128226
    esv1300352CNV Deletion17803354
    esv2622637CNV Deletion19546169
    esv2158688CNV Deletion18987734

    Human Gene Mutation Database (HGMD): GRM8
    2 Site Specific Mutation Identification with PCR Assays for GRM8:
    Cosmic IdAA Change
    120914p.M206I
    94429p.M206V
    SeqTarget long-range PCR primers for resequencing GRM8
    DNA2.0 Custom Variant and Variant Library Synthesis for GRM8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601116    OMIM disorders: --


    Find genes that share disorders with GRM8           About GenesLikeMe

    2 Novoseek inferred disease relationships for GRM8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epilepsy 6.4 2 10690750 (2)
    schizophrenia 3.99 7 15211621 (3), 17434465 (1)

    Genetic Association Database (GAD): GRM8
    Human Genome Epidemiology (HuGE) Navigator: GRM8 (18 documents)

    Export disorders for GRM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GRM8 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with GRM8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia. (PubMed id 15211621)1, 4, 9 Takaki H....Fukumaki Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    2. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (PubMed id 9473604)1, 2, 9 Wu S.... Belagaje R.M. (Brain Res. Mol. Brain Res. 1998)
    3. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. (PubMed id 10216218)1, 2, 9 Malherbe P....Mutel V. (Brain Res. Mol. Brain Res. 1999)
    4. No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. (PubMed id 11912074)1, 4, 9 Preuss U.W....Bondy B. (Alcohol Alcohol. 2002)
    5. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PubMed id 8824806)1, 3, 9 Scherer S.W....Tsui L.C. (Genomics 1996)
    6. The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1. (PubMed id 9299241)1, 2, 9 Scherer S.W.... Tsui L.-C. (Genomics 1997)
    7. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. (PubMed id 18195715)1, 4, 9 Nielsen D.A....Kreek M.J. (Mol. Psychiatry 2008)
    8. Chemerin, a novel adipokine in the regulation of angiogenesis. (PubMed id 20237162)1, 4 Bozaoglu K....Jowett J.B. (J. Clin. Endocrinol. Metab. 2010)
    9. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2918 HGNC: 4600 AceView: GRM8 Ensembl:ENSG00000179603 euGenes: HUgn2918
    ECgene: GRM8 Kegg: 2918 H-InvDB: GRM8

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GRM8 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/grm8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GRM8 gene:
    Search GeneIP for patents involving GRM8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of GRM8
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for GRM8 (mGluR8)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GRM8   OriGene RNAi products in human, mouse, rat for GRM8  
     OriGene qPCR primer pairs and template standards for GRM8   OriGene Protein Over-expression Lysate for GRM8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GRM8  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRM8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GRM8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRM8   OriGene Custom Protein Services for GRM8  

     
     
     Block miRNA regulation of human, mouse, rat GRM8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GRM8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRM8 Predesigned siRNA for gene silencing in human, mouse, rat GRM8
     QuantiFast Probe-based Assays in human, mouse, rat GRM8 QuantiTect SYBR Green Assays in human, mouse, rat GRM8
     PCR Arrays including human, mouse, rat GRM8 Search Chromatin IP Primers for GRM8
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRM8  GeneGlobe Interaction Network for GRM8
     Regulatory tfbs in GRM8 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GRM8 GenScript cDNA clones with any tag delivered in your preferred vector for GRM8
     GenScript Custom Assay Services for GRM8 GenScript Custom overexpressing Cell Line Services for GRM8
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GRM8
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for GRM8
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GRM8 antibodies
     GRM8 proteins
     GRM8 lysates
     Antibodies for GRM8
     See all of Abcam's Antibodies, Kits and Proteins for GRM8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GRM8
     Antibodies for GRM8
     ELISAs for GRM8
     CLIAs for GRM8



     Browse ESI BIO Cell Lines and PureStem Progenitors for GRM8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM8
     SwitchGear 3'UTR luciferase reporter plasmids for GRM8
     SwitchGear Promoter luciferase reporter plasmids for GRM8
     ThermoFisher Antibodies for GRM8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRM8
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRM8
     LSBio Antibodies in human, mouse, rat for GRM8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for GRM8
      Search eBioscience for proteins for GRM8
      Search eBioscience for elisas for GRM8
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRM8 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4