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Aliases for GRM8 Gene

Aliases for GRM8 Gene

  • Glutamate Receptor, Metabotropic 8 2 3
  • GPRC1H 3 4
  • MGLUR8 3 4
  • Metabotropic Glutamate Receptor 8 3
  • GLUR8 3
  • MGlu8 3

External Ids for GRM8 Gene

Previous GeneCards Identifiers for GRM8 Gene

  • GC07M124556
  • GC07M125619
  • GC07M125633
  • GC07M125609
  • GC07M125672
  • GC07M125865
  • GC07M126078
  • GC07M120439

Summaries for GRM8 Gene

Entrez Gene Summary for GRM8 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM8 Gene

GRM8 (Glutamate Receptor, Metabotropic 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and group III metabotropic glutamate receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for GRM8 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM8 Gene

  • Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. The receptors are coupled to Gi/o which inhibits adenylyl cyclase, decreasing the formation of cAMP. mGlu group III receptors are involved in spatial learning and memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8 receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1) respectively.

Gene Wiki entry for GRM8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM8 Gene

Genomics for GRM8 Gene

Regulatory Elements for GRM8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRM8 Gene

126,438,598 bp from pter
127,253,294 bp from pter
814,697 bases
Minus strand

Genomic View for GRM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM8 Gene

Proteins for GRM8 Gene

  • Protein details for GRM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metabotropic glutamate receptor 8
    Protein Accession:
    Secondary Accessions:
    • A4D0Y3
    • B0FZ74
    • B0M0L0
    • O15493
    • O95945
    • O95946
    • Q3MIV9
    • Q52M02
    • Q6J165

    Protein attributes for GRM8 Gene

    908 amino acids
    Molecular mass:
    101741 Da
    Quaternary structure:
    • Interacts with PICK1.

    Alternative splice isoforms for GRM8 Gene


neXtProt entry for GRM8 Gene

Proteomics data for GRM8 Gene at MOPED

Post-translational modifications for GRM8 Gene

  • Glycosylation at Asn95, Asn298, Asn452, Asn480, and Asn565
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM8 Gene

Antibody Products

No data available for DME Specific Peptides for GRM8 Gene

Domains for GRM8 Gene

Gene Families for GRM8 Gene

  • GRM :GPCR / Class C : Glutamate receptors, metabotropic
  • GR :Glutamate receptors

Suggested Antigen Peptide Sequences for GRM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O00222
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM8: view

Function for GRM8 Gene

Molecular function for GRM8 Gene

GENATLAS Biochemistry:
metabotropic glutamate receptor 8,groupe III,G protein coupled receptor superfamily, linked to the inhibition of cAMP cascade
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001642 group III metabotropic glutamate receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IMP 9473604
GO:0008066 glutamate receptor activity IMP 9473604
genes like me logo Genes that share ontologies with GRM8: view
genes like me logo Genes that share phenotypes with GRM8: view

Animal Models for GRM8 Gene

MGI Knock Outs for GRM8:

Animal Model Products

miRNA for GRM8 Gene

miRTarBase miRNAs that target GRM8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRM8 Gene

Localization for GRM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRM8 Gene COMPARTMENTS Subcellular localization image for GRM8 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
GO:0042734 presynaptic membrane IBA --
genes like me logo Genes that share ontologies with GRM8: view

Pathways for GRM8 Gene

genes like me logo Genes that share pathways with GRM8: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GRM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IMP 9473604
GO:0007601 visual perception TAS 9473604
GO:0007608 sensory perception of smell IEA --
GO:0030818 negative regulation of cAMP biosynthetic process IDA 11166323
genes like me logo Genes that share ontologies with GRM8: view

Compounds for GRM8 Gene

(5) Tocris Compounds for GRM8 Gene

Compound Action Cas Number
(S)-3,4-DCPG Potent, selective mGlu8a agonist [201730-11-2]
AMN 082 dihydrochloride The first selective mGlu7 agonist [97075-46-2]
CPPG Very potent group III mGlu antagonist [183364-82-1]
L-AP4 Selective group III mGlu agonist [23052-81-5]
MMPIP hydrochloride Potent, allosteric mGlu7-selective antagonist [479077-02-6]

(1) HMDB Compounds for GRM8 Gene

Compound Synonyms Cas Number PubMed IDs
L-Glutamic acid
  • (2S)-2-Aminopentanedioate

(1) Drugbank Compounds for GRM8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(14) IUPHAR Ligand for GRM8 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]AP4 Agonist Full agonist 6.7
L-AP4 Agonist Agonist 6.5
L-CCG-I Agonist Full agonist 6.3
AZ12216052 Allosteric regulator Positive 6
L-SOP Agonist Agonist 5.9
DCG-IV Antagonist Antagonist 5.5
D-AP4 Agonist Full agonist 5.5
LY354740 Agonist Full agonist 5.5
(R,S)-4-PPG Agonist Full agonist 5.3
L-glutamic acid Agonist Full agonist 5.2
(S)-3,4-DCPG Agonist Full agonist 5.1
LY341495 Antagonist Antagonist 4.7
(1S,3R)-ACPD Agonist Full agonist 4.7
MPPG Antagonist Antagonist 3.3

(3) Novoseek inferred chemical compound relationships for GRM8 Gene

Compound -log(P) Hits PubMed IDs
glutamate 70.7 16
kainate 42.4 1
nmda 10.5 1
genes like me logo Genes that share compounds with GRM8: view

Transcripts for GRM8 Gene

mRNA/cDNA for GRM8 Gene

Unigene Clusters for GRM8 Gene

Glutamate receptor, metabotropic 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRM8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRM8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - - -

Relevant External Links for GRM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRM8 Gene

mRNA expression in normal human tissues for GRM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM8 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Frontal Cortex (BA9) (5.1), Brain - Putamen (basal ganglia) (4.5), Brain - Caudate (basal ganglia) (4.3), and Brain - Cortex (4.0).

Protein differential expression in normal tissues for GRM8 Gene

This gene is overexpressed in Heart (59.0) and Adipocyte (10.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRM8 Gene

SOURCE GeneReport for Unigene cluster for GRM8 Gene Hs.449625

genes like me logo Genes that share expressions with GRM8: view

Expression partners for GRM8 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRM8 Gene

Orthologs for GRM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRM8 35
  • 93.06 (n)
  • 99.01 (a)
(Canis familiaris)
Mammalia GRM8 35
  • 93.61 (n)
  • 98.68 (a)
GRM8 36
  • 99 (a)
(Mus musculus)
Mammalia Grm8 35
  • 91.7 (n)
  • 98.1 (a)
Grm8 16
Grm8 36
  • 97 (a)
(Pan troglodytes)
Mammalia GRM8 35
  • 99.74 (n)
  • 99.78 (a)
(Rattus norvegicus)
Mammalia Grm8 35
  • 91.7 (n)
  • 98.57 (a)
(Monodelphis domestica)
Mammalia GRM8 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia GRM8 36
  • 96 (a)
(Gallus gallus)
Aves GRM8 35
  • 84.05 (n)
  • 94.16 (a)
GRM8 36
  • 94 (a)
(Anolis carolinensis)
Reptilia GRM8 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497088 35
  • 79.32 (n)
  • 90.68 (a)
(Danio rerio)
Actinopterygii Dr.26085 35
LOC569768 35
  • 73.01 (n)
  • 82.64 (a)
GRM8 (1 of 2) 36
  • 81 (a)
grm8a 36
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30361 37
  • 42 (a)
Glu-RA 37
  • 46 (a)
mtt 35
  • 51.67 (n)
  • 45.7 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRMGL5 35
  • 50.76 (n)
  • 44.67 (a)
(Caenorhabditis elegans)
Secernentea mgl-1 37
  • 37 (a)
mgl-3 36
  • 31 (a)
Species with no ortholog for GRM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM8 Gene

Gene Tree for GRM8 (if available)
Gene Tree for GRM8 (if available)

Paralogs for GRM8 Gene

Paralogs for GRM8 Gene

Selected SIMAP similar genes for GRM8 Gene using alignment to 4 proteins: Pseudogenes for GRM8 Gene

genes like me logo Genes that share paralogs with GRM8: view

Variants for GRM8 Gene

Sequence variations from dbSNP and Humsavar for GRM8 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs511 -- 126,442,761(+) TAAAC(A/G)TGGTT intron-variant
rs512 -- 126,449,616(+) CACTT(C/T)AATGT intron-variant
rs513 -- 126,456,546(+) AAAAA(-/A/AA/AAAAAAAA)TCAAA intron-variant
rs515 -- 126,476,744(+) aataa(C/G)aaatg intron-variant
rs517 -- 126,480,019(+) ctaac(C/T)gtatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRM8 Gene

Variant ID Type Subtype PubMed ID
esv2609252 CNV Deletion 19546169
nsv436533 CNV Deletion 17901297
nsv521803 CNV Gain 19592680
esv1480862 CNV Insertion 17803354
nsv889187 CNV Loss 21882294
nsv5938 CNV Insertion 18451855
esv27641 CNV Gain 19812545
esv33698 CNV Loss 17666407
esv2622637 CNV Deletion 19546169
nsv5939 CNV Loss 18451855
esv33690 CNV Loss 17666407
esv2735116 CNV Deletion 23290073
esv2158688 CNV Deletion 18987734
esv2735118 CNV Deletion 23290073
esv1009957 CNV Deletion 20482838
esv1733605 CNV Deletion 17803354
esv2606684 CNV Deletion 19546169
esv2735119 CNV Deletion 23290073
esv1000131 CNV Insertion 20482838
dgv2136e1 CNV Complex 17122850
nsv8211 CNV Loss 18304495
esv26377 CNV Gain+Loss 19812545
nsv5940 CNV Loss 18451855
nsv831121 CNV Gain 17160897
nsv889188 CNV Loss 21882294
nsv510114 CNV Loss 20534489
esv2735120 CNV Deletion 23290073
esv271306 CNV Insertion 20981092
esv272381 CNV Insertion 20981092
esv2735121 CNV Deletion 23290073
nsv889189 CNV Loss 21882294
nsv5941 CNV Insertion 18451855
nsv518034 CNV Loss 19592680
nsv437572 CNV Loss 16327808
esv2735122 CNV Deletion 23290073
esv2019229 CNV Deletion 18987734
nsv8212 CNV Loss 18304495
esv5207 CNV Deletion 18987735
esv2735123 CNV Deletion 23290073
esv1000509 CNV Deletion 20482838
esv1300352 CNV Deletion 17803354
esv2670600 CNV Deletion 23128226
nsv499782 CNV Loss 21111241
nsv517633 CNV Loss 19592680
esv23929 CNV Loss 19812545
esv271596 CNV Insertion 20981092
esv2678710 CNV Deletion 23128226
esv271135 CNV Insertion 20981092
nsv889190 CNV Loss 21882294
esv271225 CNV Insertion 20981092
nsv819682 CNV Gain 19587683
esv2668105 CNV Deletion 23128226

Relevant External Links for GRM8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM8 Gene

Disorders for GRM8 Gene

(2) Novoseek inferred disease relationships for GRM8 Gene

Disease -log(P) Hits PubMed IDs
epilepsy 6.4 2
schizophrenia 3.99 4

Relevant External Links for GRM8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GRM8: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for GRM8 Gene

Publications for GRM8 Gene

  1. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PMID: 8824806) Scherer S.W. … Tsui L.C. (Genomics 1996) 2 3 23
  2. The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1. (PMID: 9299241) Scherer S.W. … Tsui L.-C. (Genomics 1997) 3 4 23
  3. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (PMID: 9473604) Wu S. … Belagaje R.M. (Brain Res. Mol. Brain Res. 1998) 3 4 23
  4. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. (PMID: 10216218) Malherbe P. … Mutel V. (Brain Res. Mol. Brain Res. 1999) 3 4 23
  5. No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. (PMID: 11912074) Preuss U.W. … Bondy B. (Alcohol Alcohol. 2002) 3 23 48

Products for GRM8 Gene

Sources for GRM8 Gene

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