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Aliases for GRM7 Gene

Aliases for GRM7 Gene

  • Glutamate Metabotropic Receptor 7 2 3
  • Glutamate Receptor, Metabotropic 7 2 3 5
  • GPRC1G 3 4
  • MGLUR7 3 4
  • Protein Phosphatase 1, Regulatory Subunit 87 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 87 2
  • PPP1R87 3
  • GLUR7 3
  • MGLU7 3

External Ids for GRM7 Gene

Previous GeneCards Identifiers for GRM7 Gene

  • GC03P006816
  • GC03P006877

Summaries for GRM7 Gene

Entrez Gene Summary for GRM7 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

GeneCards Summary for GRM7 Gene

GRM7 (Glutamate Metabotropic Receptor 7) is a Protein Coding gene. Diseases associated with GRM7 include Attention Deficit-Hyperactivity Disorder. Among its related pathways are Taste transduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for GRM7 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM7 Gene

  • Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8.

Gene Wiki entry for GRM7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM7 Gene

Genomics for GRM7 Gene

Regulatory Elements for GRM7 Gene

Enhancers for GRM7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRM7 on UCSC Golden Path with GeneCards custom track

Promoters for GRM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRM7 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRM7 Gene

6,770,001 bp from pter
7,741,533 bp from pter
971,533 bases
Plus strand

Genomic View for GRM7 Gene

Genes around GRM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM7 Gene

Proteins for GRM7 Gene

  • Protein details for GRM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metabotropic glutamate receptor 7
    Protein Accession:
    Secondary Accessions:
    • Q8NFS2
    • Q8NFS3
    • Q8NFS4

    Protein attributes for GRM7 Gene

    915 amino acids
    Molecular mass:
    102251 Da
    Quaternary structure:
    • Interacts with PICK1.

    Three dimensional structures from OCA and Proteopedia for GRM7 Gene

    Alternative splice isoforms for GRM7 Gene


neXtProt entry for GRM7 Gene

Proteomics data for GRM7 Gene at MOPED

Post-translational modifications for GRM7 Gene

  • Glycosylation at Asn 98, Asn 458, Asn 486, and Asn 572
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GRM7 Gene

Domains & Families for GRM7 Gene

Suggested Antigen Peptide Sequences for GRM7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM7: view

Function for GRM7 Gene

Molecular function for GRM7 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for GRM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity IEA --
genes like me logo Genes that share ontologies with GRM7: view
genes like me logo Genes that share phenotypes with GRM7: view

Animal Models for GRM7 Gene

MGI Knock Outs for GRM7:

Animal Model Products

miRNA for GRM7 Gene

miRTarBase miRNAs that target GRM7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM7 Gene

Localization for GRM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRM7 Gene COMPARTMENTS Subcellular localization image for GRM7 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for GRM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005938 cell cortex IDA 9630572
GO:0030425 dendrite IDA 9630572
GO:0042734 presynaptic membrane IBA --
genes like me logo Genes that share ontologies with GRM7: view

Pathways & Interactions for GRM7 Gene

genes like me logo Genes that share pathways with GRM7: view

Gene Ontology (GO) - Biological Process for GRM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001661 conditioned taste aversion IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007605 sensory perception of sound IMP 19047183
GO:0007608 sensory perception of smell IEA --
GO:0007614 short-term memory IEA --
genes like me logo Genes that share ontologies with GRM7: view

No data available for SIGNOR curated interactions for GRM7 Gene

Drugs & Compounds for GRM7 Gene

(25) Drugs for GRM7 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 477
L-Glutamic Acid Nutra Full agonist, Agonist, antagonist, Target 0
L-AP4 Pharma Agonist Selective group III mGlu agonist 0
(+)-MCPG Pharma Antagonist 0
(<i>R,S</i>)-4-PPG Pharma Full agonist, Agonist 0

(8) Additional Compounds for GRM7 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GRM7 Gene

Compound Action Cas Number
(RS)-PPG Potent, selective mGlu8 agonist 120667-15-4
(S)-3,4-DCPG Potent, selective mGlu8a agonist 201730-11-2
ACPT-I Group III mGlu agonist 194918-76-8
L-AP4 Selective group III mGlu agonist 23052-81-5
O-Phospho-L-serine Group III mGlu agonist 407-41-0
genes like me logo Genes that share compounds with GRM7: view

Transcripts for GRM7 Gene

Unigene Clusters for GRM7 Gene

Glutamate receptor, metabotropic 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRM7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2: - - - - - -

Relevant External Links for GRM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRM7 Gene

mRNA expression in normal human tissues for GRM7 Gene

mRNA differential expression in normal tissues according to GTEx for GRM7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.9), Brain - Hypothalamus (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Hippocampus (x5.1), Brain - Cortex (x4.9), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for GRM7 Gene

This gene is overexpressed in Placenta (23.8), Heart (22.5), and Platelet (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRM7 Gene

SOURCE GeneReport for Unigene cluster for GRM7 Gene Hs.660131

mRNA Expression by UniProt/SwissProt for GRM7 Gene

Tissue specificity: Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
genes like me logo Genes that share expression patterns with GRM7: view

Protein tissue co-expression partners for GRM7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GRM7 Gene

Orthologs for GRM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRM7 35
  • 92.82 (n)
  • 99.34 (a)
GRM7 36
  • 99 (a)
(Canis familiaris)
Mammalia LOC484674 35
  • 94.72 (n)
  • 99.67 (a)
GRM7 36
  • 100 (a)
(Mus musculus)
Mammalia Grm7 35
  • 91.66 (n)
  • 99.45 (a)
Grm7 16
Grm7 36
  • 99 (a)
(Pan troglodytes)
Mammalia GRM7 35
  • 99.45 (n)
  • 99.67 (a)
GRM7 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Grm7 35
  • 91.51 (n)
  • 99.34 (a)
(Monodelphis domestica)
Mammalia GRM7 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
(Gallus gallus)
Aves GRM7 35
  • 83.26 (n)
  • 92.11 (a)
GRM7 36
  • 91 (a)
(Anolis carolinensis)
Reptilia GRM7 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grm7 35
  • 76.63 (n)
  • 86.78 (a)
Str.3166 35
(Danio rerio)
Actinopterygii LOC100331190 35
  • 73.48 (n)
  • 83.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30361 37
  • 41 (a)
Glu-RA 37
  • 47 (a)
(Caenorhabditis elegans)
Secernentea mgl-1 37
  • 38 (a)
mgl-3 35
  • 47.48 (n)
  • 39.81 (a)
Species with no ortholog for GRM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM7 Gene

Gene Tree for GRM7 (if available)
Gene Tree for GRM7 (if available)

Paralogs for GRM7 Gene

Paralogs for GRM7 Gene

genes like me logo Genes that share paralogs with GRM7: view

Variants for GRM7 Gene

Sequence variations from dbSNP and Humsavar for GRM7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2229902 - 7,452,730(+) TGACT(A/T)CCGGG nc-transcript-variant, reference, missense
rs7634846 - 7,461,690(+) GTCTG(A/G)TCGGG nc-transcript-variant, reference, missense
rs1485174 - 7,579,141(-) AGAAC(C/T)CCTCT nc-transcript-variant, reference, synonymous-codon
rs332933 -- 7,713,309(-) aaata(C/T)gaaaa intron-variant
rs332934 -- 7,712,258(+) TCATA(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRM7 Gene

Variant ID Type Subtype PubMed ID
nsv876493 CNV Gain 21882294
nsv518755 CNV Loss 19592680
nsv876496 CNV Loss 21882294
nsv507081 CNV Insertion 20534489
nsv876497 CNV Gain 21882294
esv9380 OTHER Inversion 19470904
esv2674760 CNV Deletion 23128226
esv2724857 CNV Deletion 23290073
nsv526975 CNV Loss 19592680
esv2752015 CNV Loss 17911159
nsv876498 CNV Loss 21882294
esv24058 CNV Loss 19812545
esv2590123 CNV Insertion 19546169
esv270358 CNV Insertion 20981092
esv274141 CNV Insertion 20981092
esv1005105 CNV Insertion 20482838
esv271066 CNV Insertion 20981092
esv272371 CNV Insertion 20981092
nsv237180 CNV Loss 16902084
esv2724858 CNV Deletion 23290073
nsv460377 CNV Gain 19166990
nsv876499 CNV Loss 21882294
nsv818125 CNV Loss 17921354
esv5346 CNV Deletion 18987735
esv8633 CNV Loss 19470904
esv2662447 CNV Deletion 23128226
nsv236588 CNV Loss 16902084
esv2724859 CNV Deletion 23290073
esv28710 CNV Gain 19812545
nsv876500 CNV Loss 21882294
esv2656815 CNV Deletion 23128226
esv2670179 CNV Deletion 23128226
esv22695 CNV Loss 19812545
esv2664422 CNV Deletion 23128226
esv2724860 CNV Deletion 23290073
nsv834610 CNV Gain 17160897
nsv818126 CNV Loss 17921354
dgv1434e1 CNV Complex 17122850
nsv876501 CNV Gain 21882294
nsv876502 CNV Loss 21882294
esv268940 CNV Insertion 20981092
nsv524074 CNV Loss 19592680
esv2724862 CNV Deletion 23290073
esv1450820 CNV Insertion 17803354
nsv876503 CNV Gain 21882294
nsv524307 CNV Loss 19592680
esv998955 CNV Deletion 20482838
nsv876504 CNV Loss 21882294
nsv237477 CNV Loss 16902084
esv2455660 CNV Deletion 19546169
esv2342652 CNV Deletion 18987734
esv2660996 CNV Deletion 23128226
esv2678085 CNV Deletion 23128226

Variation tolerance for GRM7 Gene

Residual Variation Intolerance Score: 7.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRM7 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM7 Gene

Disorders for GRM7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRM7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards
Search GRM7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRM7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM7 Gene

Publications for GRM7 Gene

  1. Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. (PMID: 8840028) Makoff A. … Emson P. (Brain Res. Mol. Brain Res. 1996) 2 3 4 23 67
  2. A genome-wide association study for age-related hearing impairment in the Saami. (PMID: 20068591) Van Laer L. … Van Camp G. (Eur. J. Hum. Genet. 2010) 3 23
  3. GRM7 variants confer susceptibility to age-related hearing impairment. (PMID: 19047183) Friedman R.A. … Van Camp G. (Hum. Mol. Genet. 2009) 3 23
  4. Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. (PMID: 19351574) Shibata H. … Fukumaki Y. (Psychiatry Res 2009) 3 23
  5. A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population. (PMID: 19638256) Ganda C. … Wildenauer D.B. (Int. J. Neuropsychopharmacol. 2009) 3 23

Products for GRM7 Gene

Sources for GRM7 Gene