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GRM7 Gene

protein-coding GIFtS: 68

GC03P006877

glutamate receptor, metabotropic 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ40498 ^²
GLUR7 ^¹, ²
GPRC1G ^¹, ², ³
MGLUR7 ^¹, ², ³, ⁵
mGlu7 ^¹, ²
mGluR7 ^³

Descriptions
glutamate receptor, metabotropic 7 ^²

External Ids
HGNC: 4599¹
Entrez Gene: 2917²
UniProtKB: Q14831³
Ensembl: ENSG00000196277⁷

Search outside databases for aliases for GRM7 gene

Previous GC identifer: GC03P006816

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRM7:

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates

both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved

in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.

The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been

divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms,

and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown

to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6,

GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade

but differ in their agonist selectivities. Multiple transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRM7_HUMAN, Q14831

Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that

inhibits adenylate cyclase activity

Gene Wiki entry for GRM7 (Metabotropic_glutamate_receptor_7)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRM7 gene

Entrez Gene cytogenetic band: 3p26.1-p25.1 Ensembl cytogenetic band: 3p26.1 HGNC cytogenetic band: 3p26-p25

GRM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P006877: (about GC identifiers)

Start:	6,877,927 bp from pter
End:	7,758,217 bp from pter
Size:	880,291 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GRM7_HUMAN, Q14831 (See protein sequence)

Recommended Name: Metabotropic glutamate receptor 7 precursor

Size: 915 amino acids; 102251 Da

Subunit: Interacts with PICK1 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q8NFS2 Q8NFS3 Q8NFS4

Alternative splicing: 5 isoforms: Q14831-1 Q14831-2 Q14831-3 Q14831-4 Q14831-5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000835.1 NP_870989.1

ENSEMBL proteins:

ENSP00000373986 ENSP00000373987 ENSP00000385664 ENSP00000384585 ENSP00000350348

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Metabotropic Glutamate Receptor 6+7, Metabotropic Glutamate Receptor 7)
	Human Recombinant Proteins from Abnova (GRM7)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9473604
GO:0045211	postsynaptic membrane	TAS	12052533
GO:0048787	presynaptic active zone membrane	TAS	12052533

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Antibodies for GRM7:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GRM7
	Sigma-Aldrich Antibodies for GRM7
	R&D Systems Antibodies for GRM7 (mGluR7)
	Antibodies from Abcam (Metabotropic Glutamate Receptor 6+7, Metabotropic Glutamate Receptor 7), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GRM7)
	Novus Biologicals Antibodies for GRM7

Assays for GRM7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14831

ProtoNet protein and cluster: Q14831

4 Blocks protein families:

IPB000162 Metabotropic glutamate receptor signature

IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)

IPB001828 Extracellular ligand-binding receptor

IPB001883 Metabotropic glutamate receptor 7 signature

UniProtKB/Swiss-Prot: GRM7_HUMAN, Q14831

Similarity: Belongs to the G-protein coupled receptor 3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRM7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRM7)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000844

Applied Biosystems Silencer® siRNAs for GRM7

Sigma-Aldrich siRNA and siRNA Panels for GRM7

Sigma-Aldrich shRNA Panels and shRNA for GRM7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GRM7
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000844
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000844
untagged cDNA clones in CMV expression vector (see all 3): NM_000844

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_181874

UniProtKB/Swiss-Prot: GRM7_HUMAN, Q14831

Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that

inhibits adenylate cyclase activity

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Grm7):

behavior/neurological

homeostasis/metabolism

life span-post-weaning/aging

nervous system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	9473604
GO:0005245	voltage-gated calcium channel activity	IEA	--
GO:0005246	calcium channel regulator activity	IEA	--
GO:0008066	glutamate receptor activity	TAS	9473604

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GRM7 (Your Favorite Gene powered by Ingenuity) (see all 7 )

cAMP-mediated Signaling
Synaptic Long Term Depression
CREB Signaling in Neurons
Synaptic Long Term Potentiation
Glutamate Receptor Signaling

GeneDecks GRM7 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GRM7

5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001661	conditioned taste aversion	IEA	--
GO:0001662	behavioral fear response	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0007194	negative regulation of adenylate cyclase activity	TAS	9473604

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRM7

Sigma-Aldrich Small Molecules for GRM7:

Antagonist Agonist Allosteric Modulator

Compounds for GRM7 available from Tocris Bioscience

Compound	Action	CAS number
AMN 082 dihydrochloride	The first selective mGlu7 agonist	[83027-13-8]
MAP4	Potent group II mGlu agonist. Also specific group III mGlu antagonist	[157381-42-5]
CPPG	Very potent group III mGlu antagonist	[183364-82-1]
MMPIP hydrochloride	Potent, allosteric mGlu7-selective antagonist	[479077-02-6]

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5 Novoseek chemical compound relationships for GRM7 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
forskolin	29.74	1	9473604 (1)
cyclic amp	27.33	3	10488094 (2)
inositol 1,4,5 trisphosphate	23.80	1	11050109 (1)
calcium	6.37	4	11050109 (1), 11825890 (1), 17609420 (1)
potassium	0.00	1	12021391 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRM7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRM7)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000844

Sigma-Aldrich siRNA and siRNA Panels for GRM7

Sigma-Aldrich shRNA Panels and shRNA for GRM7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000844 NM_181874

REFSEQ mRNAs for GRM7 gene (2 alternative transcripts):

NM_000844.2 NM_181874.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000844 NM_181874

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000844
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000844
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000844

Additional cDNA sequence:

AB209214.1 AK097817.1 AK123326.1 AK312488.1 BC136458.1 BC136459.1 X94552.1

10 DOTS entries:

DT.100736604 DT.104685 DT.101958459 DT.410186 DT.99930143 DT.101978773 DT.432870 DT.95097965

DT.100016381 DT.99929572

20 AceView cDNA sequences:

BI827857 NM_181875 AK097817 BI545320 AW511101 CA313509 BP360775 BP360766

BX280590 BM701852 AF458053 AF458054 AF458052 X94552 CD609653 CD609652

NM_181874 NM_000844 U92458 BG187126

highest scoring ESTs for GRM7:

X94552 AI672542 AW511101 AA001706 AA021165 AA021170 AF458052 AI701722 AW002975 BI827857

Unigene Cluster for GRM7:

Glutamate receptor, metabotropic 7

Hs.660131 [show with all ESTs]

Unigene Representative Sequence: NM_181874

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for GRM7

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:											-						-		-				-		-
SP2:											-						-		-				-		-				-
SP3:

About this scheme

ECgene alternative splicing isoforms for GRM7

5 Ensembl transcripts including schematic representations:

ENST00000389335 ENST00000389336 ENST00000403881 ENST00000402647 ENST00000357716

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GRM7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRM7

¹ / ² / ³

6 probe-sets matching GRM7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
72582_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI672542	0.80	1.00	0.91	1
31585_at²^{, 3}	U95-A	1	1.00	1.00	0.14	0.36	X94552	1.00	1.00	1.00	1
207548_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000844	0.60	1.00	0.82	1
217008_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X94552	1.00	1.00	1.00	1
207548_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217008_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRM7 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATGTTTTTT

SOURCE GeneReport for Unigene cluster: Hs.660131
Expression variation in blood from EXPOLDB for GRM7
UniProtKB/Swiss-Prot: GRM7_HUMAN, Q14831
Tissue specificity: Expressed in many areas of the brain, especially in the cerebral cortex,
hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be
restricted to isoform 3 and isoform 4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRM7 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRM7¹	--	glutamate receptor, metabotropic 7	94.59(n) 99.56(a)	484674 XM_541789.2 XP_541789.2
chimpanzee (Pan troglodytes)	GRM7¹	--	glutamate receptor, metabotropic 7	99.45(n) 99.67(a)	460140 XM_516252.2 XP_516252.2
rat (Rattus norvegicus)	Grm7¹	--	glutamate receptor, metabotropic 7	91.51(n) 99.34(a)	81672 NM_031040.1 NP_112302.1
mouse (Mus musculus)	Grm7^{1, 5}	6⁵	glutamate receptor, metabotropic 7^{1, 5}	91.66(n)¹ 99.45(a)¹	108073¹ NM_177328.3¹ NP_796302.2¹ AK032068⁵ AK047160⁵ (see all 10)
chicken (Gallus gallus)	GRM7¹	--	glutamate receptor, metabotropic 7	83.05(n) 91.75(a)	416112 XM_414442.2 XP_414442.2

About this table Species with no ortholog for GRM7

ENSEMBL Gene Tree for GRM7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRM7 gene

GRM4² GRM8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/5664 NCBI SNPs in GRM7 are shown (see all 5664 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 2053)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs339807^1,2	A,C,F,H	6876090(-)	`ATGTTC/TATGGT`	2	--	ng5¹		7	EU EA WA NA	540
	rs2229902^1,2	C,F,H	7469417(+)	`TGACTA/TCCGGG`	2	Y/F	mis¹ ese³		13	MN NA EU EA WA	1050
	rs9878412^1,2	C,F,H	7757314(+)	`CAACTC/TGGCTG`	2	--	ut3¹		4	EU EA WA	410
	rs7634846^1,2	A,H	7478377(+)	`GTCTGA/GTCGGG`	2	I/V	mis¹		4	EU EA WA	418
	rs9826579^1,2	F,H	7757371(+)	`CGCCCT/CGGCTC`	2	--	ut3¹		3	EU EA	292
	rs17726576^1,2	F,H	7757551(+)	`GTTTTC/TATAGA`	2	--	ut3¹		7	NA EU EA WA	558
--	rs17046184^1,2	F	6877070(+)	`CGTCCG/CAGGTT`	2	--	ng5¹		2	MN EA	356
	rs1485175^1,2	A,C,F,H,O	7595789(-)	`TCATCA/GTAGTC`	2	Y/Y	syn¹		12	MN EA EU WA NA	2522
	rs1485174^1,2	C,F,H,O	7595828(-)	`AGAACC/TCCTCT`	2	G/G	syn¹ ese³		17	MN NA EU EA WA	1638
	rs7614915^1,2	C,F,H	7595382(+)	`TCTTCC/TTGGCA`	2	L/L	syn¹ ese³		17	EA NA EU WA	1518

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HapMap Linkage Disequilibrium images for GRM7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604101

1 Novoseek disease relationship for GRM7 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
epilepsy	11.70	4	10690750 (3), 15857425 (1)

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Human Gene Mutation Database: GRM7
Genetic Association Database: GRM7
Human Genome Epidemiology Navigator: GRM7 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/60 PubMed articles for GRM7 gene (see all 60 ):

Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. (PubMed id 8840028)^{1, 2, 3, 4} Makoff A....Emson P. (1996)
Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia. (PubMed id 11163549)^{3, 4, 6} Bolonna A.A.... Makoff A.J. (2001)
Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (PubMed id 9473604)^{1, 3, 4} Wu S....Belagaje R.M. (1998)
No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. (PubMed id 11912074)^{1, 3, 6} Preuss U.W....Bondy B. (2002)
A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. (PubMed id 9144652)^{1, 3, 4} Flor P.J.... Kuhn R. (1997)
Characterization of three novel isoforms of the metabotropic glutamate receptor 7 (GRM7). (PubMed id 12052533)^{3, 4} Schulz H.L.... Weber B.H.F. (2002)
Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. (PubMed id 8288585)^{2, 3} Okamoto N....Nakanishi S. (1994)
A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7. (PubMed id 10488094)^{1, 3} Nakajima Y....Nakanishi S. (1999)
A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia. (PubMed id 18329248)^{1, 3} Ohtsuki T....Arinami T. (2008)
Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia. (PubMed id 19351574)^{1, 3} Shibata H....Fukumaki Y. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2917	HGNC: 4599	AceView: GRM7	Ensembl:ENSG00000196277	euGenes: HUgn2917
ECgene: GRM7	H-InvDB: GRM7

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GRM7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GRM7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRM7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRM7		Antibodies for GRM7
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRM7		Small molecules for GRM7
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GRM7)
	Antibodies (GRM7)
	Chimera RNAi (GRM7)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Metabotropic Glutamate Receptor 6+7, Metabotropic Glutamate Receptor 7)
	Antibodies (Metabotropic Glutamate Receptor 6+7, Metabotropic Glutamate Receptor 7)

Search OriGene for GRM7

Tocris compounds for GRM7

	Drugs for GRM7
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRM7

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GRM7 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for GRM7

Summaries
for GRM7

Genomic Location
for GRM7

Proteins
for GRM7

Protein Domains/
Families
for GRM7

Gene Function
for GRM7

Pathways & Interactions
for GRM7

Drugs & Compounds
for GRM7

Transcripts
for GRM7

Expression
for GRM7

Orthologs
for GRM7

Paralogs
for GRM7

SNPs/Variants
for GRM7

Disorders & Mutations
for GRM7

Medical News
for GRM7

Publications
for GRM7

Search for GRM7

Genome Databases showing GRM7

Other Databases showing GRM7

Specialized Databases showing GRM7

Licensable Technologies
for GRM7

Services
for GRM7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRM7 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor GRM7

Summariesfor GRM7

Genomic Locationfor GRM7

Proteinsfor GRM7

Protein Domains/Familiesfor GRM7

Gene Functionfor GRM7

Pathways & Interactionsfor GRM7

Drugs & Compoundsfor GRM7

Transcriptsfor GRM7

Expression for GRM7

Orthologsfor GRM7

Paralogsfor GRM7

SNPs/Variantsfor GRM7

Disorders & Mutationsfor GRM7

Medical Newsfor GRM7

Publicationsfor GRM7

Search for GRM7

Genome Databases showing GRM7

Other Databases showing GRM7

Specialized Databases showing GRM7

Licensable Technologiesfor GRM7

Servicesfor GRM7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRM7

Summaries
for GRM7

Genomic Location
for GRM7

Proteins
for GRM7

Protein Domains/
Families
for GRM7

Gene Function
for GRM7

Pathways & Interactions
for GRM7

Drugs & Compounds
for GRM7

Transcripts
for GRM7

Expression
for GRM7

Orthologs
for GRM7

Paralogs
for GRM7

SNPs/Variants
for GRM7

Disorders & Mutations
for GRM7

Medical News
for GRM7

Publications
for GRM7

Licensable Technologies
for GRM7

Services
for GRM7