Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRM6 Gene

protein-coding   GIFtS: 66
GCID: GC05M178392

Glutamate Receptor, Metabotropic 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamate Receptor, Metabotropic 61 2     mGlu62
MGLUR62 3 5     Metabotropic Glutamate Receptor 62
GPRC1F2 3     mGluR63
CSNB1B2 5     

External Ids:    HGNC: 45981   Entrez Gene: 29162   Ensembl: ENSG000001132627   OMIM: 6040965   UniProtKB: O153033   

Export aliases for GRM6 gene to outside databases

Previous GC identifers: GC05M178429 GC05M179301 GC05M178505 GC05M178324 GC05M173132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRM6 Gene:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic
and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain
function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a
family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology,
putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes
GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but
differ in their agonist selectivities. (provided by RefSeq, Feb 2012)

GeneCards Summary for GRM6 Gene: 
GRM6 (glutamate receptor, metabotropic 6) is a protein-coding gene. Diseases associated with GRM6 include congenital stationary night blindness, type 1b, and amblyopia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and GPCRs, Class C Metabotropic glutamate, pheromone. GO annotations related to this gene include adenylate cyclase inhibiting G-protein coupled glutamate receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303
Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
cyclase activity

summary for GRM6 Gene:
Metabotropic Glutamate (mGlu) group III receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group I and mGlu group II receptors. Group III receptors are divided
into four subtypes, mGlu4, mGlu6, mGlu7 and mGlu8. The receptors are coupled to Gi/o which inhibits adenylyl
cyclase, decreasing the formation of cAMP. mGlu group III receptors are involved in spatial learning and
memory, and umami taste (mGlu4), stimulation of photoreceptors (mGlu6), long term depression (mGlu7) and
presynaptic inhibition in the perforant pathway (mGlu8). The human genes for mGlu4, mGlu6, mGlu7 and mGlu8
receptors have been localized to chromosomes 6 (6p21.3), 5 (5q35), 3 (3p26-p25) and 7 (7q31.3-q32.1)
respectively.

Gene Wiki entry for GRM6 (Metabotropic glutamate receptor 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRM6 gene promoter:
         AhR   RFX1   AML1a   CUTL1   CREB   Egr-2   PPAR-gamma1   deltaCREB   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRM6 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRM6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

GRM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M178392:  view genomic region     (about GC identifiers)

Start:
178,405,328 bp from pter      End:
178,423,207 bp from pter
Size:
17,880 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 6 precursor  
Size: 877 amino acids; 95468 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for GRM6: NX_O15303

Explore proteomics data for GRM6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15303

  • GRM6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRM6 Protein Expression
    REFSEQ proteins: NP_000834.2  
    ENSEMBL proteins: 
     ENSP00000430767   ENSP00000231188  
    Reactome Protein details: O15303
    Human Recombinant Protein Products for GRM6: 
    EMD Millipore Purified and/or Recombinant GRM6 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRM6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for GRM6
    GenScript Custom Purified and Recombinant Proteins Services for GRM6
    Novus Biologicals GRM6 Proteins
    Novus Biologicals GRM6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRM6 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA17405131
    GO:0005789endoplasmic reticulum membrane IDA17405131
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA17405131
    GO:0016021integral to membrane ----

    GRM6 for ontologies           About GeneDecksing



    GRM6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRM6
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for GRM6
    GenScript Custom Superior Antibodies Services for GRM6
    Novus Biologicals GRM6 Antibodies
    Abcam antibodies for GRM6
    Cloud-Clone Corp. Antibodies for GRM6 
    ThermoFisher Antibody for GRM6
    LSBio Antibodies in human, mouse, rat for GRM6 

    Assay Products for GRM6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRM6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRM6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRM6 
    Cloud-Clone Corp. CLIAs for GRM6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GR: Glutamate receptors
    GRM: GPCR / Class C : Glutamate receptors, metabotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: mGlu6 receptor 
    Metabotropic glutamate receptors

    5/7 InterPro protein domains (see all 7):
     IPR011500 GPCR_3_9-Cys_dom
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR000112 GPCR_3_mtglu_rcpt_6
     IPR017978 GPCR_3_C

    Graphical View of Domain Structure for InterPro Entry O15303

    ProtoNet protein and cluster: O15303

    4 Blocks protein domains:
    IPB000112 Metabotropic glutamate receptor 6 signature
    IPB000162 Metabotropic glutamate receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303
    Similarity: Belongs to the G-protein coupled receptor 3 family


    GRM6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRM6_HUMAN, O15303
    Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
    cyclase activity

         Genatlas biochemistry entry for GRM6:
    metabotropic glutamate receptor 6,groupe III,G protein coupled receptor superfamily,restrictidly expressed in
    retinal bipolar cells,linked to the inhibition of cAMP cascade

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001640adenylate cyclase inhibiting G-protein coupled glutamate receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS9215706
    GO:0005515protein binding IPI17405131
    GO:0008066glutamate receptor activity TAS9215706
    GO:0042803protein homodimerization activity IPI17405131
         
    GRM6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GRM6:
     Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Grm6):
     behavior/neurological  nervous system  vision/eye 

    GRM6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grm6tm1Nak for GRM6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRM6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRM6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRM6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRM6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRM6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate GRM6:
    hsa-miR-1270 hsa-miR-620 hsa-miR-532-5p hsa-miR-185 hsa-miR-4306 hsa-miR-548aa
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRM6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRM6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRM6
    Sirion Biotech Customized adenovirus for overexpression of GRM6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for GRM6 (see all 5)
    OriGene ORF clones in mouse, rat for GRM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRM6 (NM_000843)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM6
    Sirion Biotech Customized lentivirus for stable overexpression of GRM6 
                         Customized lentivirus expression plasmids for stable overexpression of GRM6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRM6
    Search LifeMap BioReagents cell lines for GRM6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRM6 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: Glutamatergic Excitation0.33
    GPCRs, Class C Metabotropic glutamate, pheromone0.33
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4CREB Pathway
    CREB Pathway0.68
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GRM6
        Glutamic acid signaling

    1 R&D Systems Pathway for GRM6
        Synaptic Neurotransmission: Glutamatergic Excitation

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRM6
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Signaling in Gap Junctions

    1 BioSystems Pathway for GRM6
        GPCRs, Class C Metabotropic glutamate, pheromone

    5/6        Reactome Pathways for GRM6 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    G alpha (i) signalling events


    2         Kegg Pathways  (Kegg details for GRM6):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse


    GRM6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRM6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for GRM6 (O153033 ENSP000002311884) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAO1P094713, ENSP000002624934I2D: score=1 STRING: ENSP00000262493
    GRIP1Q9Y3R03I2D: score=2 
    SDCBPO005603I2D: score=2 
    FOXO3O435243I2D: score=1 
    PRKAG1P546193I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway ----
    GO:0007216G-protein coupled glutamate receptor signaling pathway IMP--
    GO:0007268synaptic transmission IEA--

    GRM6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRM6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for GRM6

    Compounds for GRM6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MSOPSpecific group III mGlu antagonist[66515-29-5]
    L-AP4Selective group III mGlu agonist[23052-81-5]
    (S)-3,4-DCPG Potent, selective mGlu8a agonist [201730-11-2]
    AMN 082 dihydrochlorideThe first selective mGlu7 agonist[97075-46-2]
    CPPGVery potent group III mGlu antagonist[183364-82-1]

    10/12 IUPHAR Ligands for GRM6 (mGlu6 receptor) (see all 12)    About this table 
    LigandTypeActionAffinityPubmed IDs
    L-AP4
    AgonistFull agonist6.7 - 7.311166323 9144651
    LY379268
    AgonistFull agonist6.410090786
    L-SOP
    AgonistFull agonist6.49144651
    (2S,1S,2S)-L-CCG-I
    AgonistFull agonist6.29144651
    LY354740
    AgonistFull agonist5.510090786
    (S)-3,4-DCPG
    AgonistFull agonist5.411166323
    (R,S)-4-PPG
    AgonistFull agonist5.311166323 10336568
    L-glutamic acid
    AgonistFull agonist5.29144651
    (1S,3R)-ACPD
    AgonistFull agonist4.79144651
    [3H]LY341495
    AntagonistAntagonist4.511138847

    4 Novoseek inferred chemical compound relationships for GRM6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 73.9 45 11292414 (4), 17430614 (2), 11179672 (2), 9357538 (2) (see all 23)
    kainate 51.1 3 18653656 (1), 10515165 (1)
    nmda 38.2 2 10515165 (1)
    aspartate 9.78 1 8759641 (1)

    Search CenterWatch for drugs/clinical trials and news about GRM6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRM6 gene: 
    NM_000843.3  

    Unigene Cluster for GRM6:

    Glutamate receptor, metabotropic 6
    Hs.248131  [show with all ESTs]
    Unigene Representative Sequence: NM_000843
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517717(uc010jla.1 uc003mjs.1) ENST00000519003 ENST00000518082
    ENST00000519175 ENST00000231188(uc003mjq.3 uc003mjr.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRM6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate GRM6:
    hsa-miR-1270 hsa-miR-620 hsa-miR-532-5p hsa-miR-185 hsa-miR-4306 hsa-miR-548aa
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for GRM6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRM6
    Clone
    Products:
         
    OriGene clones in human, mouse for GRM6 (see all 5)
    OriGene ORF clones in mouse, rat for GRM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRM6 (NM_000843)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM6
    Sirion Biotech Customized lentivirus for stable overexpression of GRM6 
                         Customized lentivirus expression plasmids for stable overexpression of GRM6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRM6
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GRM6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRM6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRM6

    Additional mRNA sequence: 

    AJ245871.1 AJ245872.1 BX647168.1 

    1 DOTS entry:

    DT.91701632 

    8 AceView cDNA sequences:

    BM681239 NM_000843 BM665594 AJ245871 AJ245872 BX647168 BM726590 W25882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRM6 expression in normal human tissues (normalized intensities)      GRM6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACACAAT
    GRM6 Expression
    About this image


    GRM6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Type7 On Cone Bipolar Cells Inner Nuclear Layer

    See GRM6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRM6

    SOURCE GeneReport for Unigene cluster: Hs.248131
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRM6: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GRM6
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat GRM6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRM6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRM6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRM6 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grm61 , 5 glutamate receptor, metabotropic 61, 5 87.85(n)1
    94.23(a)1
      11 (30.93 cM)5
    1080721  NM_173372.21  NP_775548.21 
     508506855 
    lizard
    (Anolis carolinensis)
    Reptilia GRM66
    glutamate receptor, metabotropic 6
    73(a)
    1 ↔ 1
    2(69578857-69645929)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5684841 glutamate receptor, metabotropic 73.16(n)
    76.15(a)
      568484  NM_001123292.1  NP_001116764.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glu-RA3 metabotropic glutamate receptor
    signaling pathway more
    44(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for GRM6 (if available)
    TreeFam Gene Tree for GRM6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRM6 gene
    GRM72  GRM42  TAS1R22  GRM82  TAS1R32  GRM22  GRM32  TAS1R12  
    GRM52  GRM12  GPRC6A2  
    9 SIMAP similar genes for GRM6 using alignment to 1 protein entry:     GRM6_HUMAN:
    DKFZp686H1993    GRM8    GRM4    GRM7    GRM2    GRM3
    GRM1    GRM5    CASR

    GRM6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/798 SNPs in GRM6 are shown (see all 798)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0307564
    Night blindness, congenital stationary, 1B (CSNB1B)4--see VAR_0307562 G S mis40--------
    VAR_0361954
    A breast cancer sample4--see VAR_0361952 S F mis40--------
    VAR_0307574
    Night blindness, congenital stationary, 1B (CSNB1B)4--see VAR_0307572 E K mis40--------
    rs626386251,2
    Cpathogenic1173137254(-) TCAACA/GAGGCC 2 K E mis10--------
    rs626386241,2
    Cpathogenic1173140382(-) CCCTGC/TAGGTG 2 Q * stg10--------
    rs626382141,2
    Cpathogenic1173140643(-) CGGGCC/TGAGAG 2 R * stg11Minor allele frequency- T:0.00NA 4432
    rs626382081,2
    Cpathogenic1173140939(-) GCCCTA/GCGGGC 2 Y C mis10--------
    rs1214343041,2
    Cpathogenic1173143325(-) TGTGAT/CTGATG 2 /T /I mis11Minor allele frequency- C:0.00NA 4538
    rs626382021,2
    Cpathogenic1173148749(-) TCGTGA/GGCGCC 2 S G mis10--------
    rs626381971,2
    Cpathogenic1173149060(-) GTTCCC/TGGTGC 2 P L mis10--------

    HapMap Linkage Disequilibrium report for GRM6 (178405328 - 178423207 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for GRM6:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv364n21CNV Loss19592680
    dgv6389n71CNV Gain21882294
    nsv883221CNV Gain21882294


    Human Gene Mutation Database (HGMD): GRM6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GRM6
    DNA2.0 Custom Variant and Variant Library Synthesis for GRM6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604096   
    OMIM disorders: 257270  
    UniProtKB/Swiss-Prot: GRM6_HUMAN, O15303
  • Night blindness, congenital stationary, 1B (CSNB1B) [MIM:257270]: A non-progressive retinal disorder
    characterized by impaired night vision. Congenital stationary night blindness type 1B is an autosomal recessive
    form associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when
    maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that
    normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable
    a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the
    second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced on
    response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing
    white vs black objects on a gray background. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 13 diseases for GRM6:    About MalaCards
    congenital stationary night blindness, type 1b    amblyopia    night blindness, congenital stationary, type 1    suppression amblyopia
    congenital stationary night blindness    night blindness    blindness    retinal disease
    myopia    retinitis    prostate cancer    prostatitis
    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for GRM6:
    Night blindness     Suppression amblyopia     Myopia

    GRM6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for GRM6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    night blindness, congenital stationary 93.3 8 16622103 (1), 19666700 (1), 19862333 (1), 17405131 (1)

    Genetic Association Database (GAD): GRM6
    Human Genome Epidemiology (HuGE) Navigator: GRM6 (8 documents)

    Export disorders for GRM6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRM6 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with GRM6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. (PubMed id 9215706)1, 2, 3, 9 Hashimoto T....Nakanishi S. (1997)
    2. Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. (PubMed id 15781871)1, 2, 9 Dryja T.P.... Rajagopalan A.S. (2005)
    3. Sequence variations of GRM6 in patients with high myo pia. (PubMed id 19862333)1, 4, 9 Xu X....Zhang Q. (2009)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Response to methadone maintenance treatment is associ ated with the MYOCD and GRM6 genes. (PubMed id 20560679)1, 4 Fonseca F....Torrens M. (2010)
    6. Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (2010)
    7. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    9. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. (PubMed id 18195715)1, 4 Nielsen D.A....Kreek M.J. (2008)
    10. Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. (PubMed id 17405131)1, 9 Zeitz C....Berger W. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2916 HGNC: 4598 AceView: GRM6 Ensembl:ENSG00000113262 euGenes: HUgn2916
    ECgene: GRM6 Kegg: 2916 H-InvDB: GRM6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRM6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRM6 gene:
    Search GeneIP for patents involving GRM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of GRM6
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Purified and/or Recombinant GRM6 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for GRM6  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for GRM6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GRM6  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRM6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GRM6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRM6   OriGene Custom Protein Services for GRM6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRM6
     QIAGEN SeqTarget long-range PCR primers for resequencing GRM6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRM6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRM6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRM6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRM6
     GenScript Custom Purified and Recombinant Proteins Services for GRM6 GenScript cDNA clones with any tag delivered in your preferred vector for GRM6
     GenScript Custom Assay Services for GRM6 GenScript Custom Superior Antibodies Services for GRM6
     GenScript Custom overexpressing Cell Line Services for GRM6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in GRM6 promoter
     Search Chromatin IP Primers for GRM6
     RT2 qPCR Primer Assay in human, mouse / rat GRM6
     Search GNC Networks for GRM6
     SABiosciences PCR Arrays including human, mouse / rat GRM6
     Tocris compounds for GRM6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for GRM6
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     GRM6 antibodies
     GRM6 proteins
     GRM6 lysates
     Antibodies for GRM6
     See all of Abcam's Antibodies, Kits and Proteins for GRM6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for GRM6
     Antibodies for GRM6
     ELISAs for GRM6
     CLIAs for GRM6
     Search LifeMap BioReagents cell lines for GRM6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for GRM6
     SwitchGear Promoter luciferase reporter plasmids for GRM6
     ThermoFisher Antibody for GRM6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for GRM6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRM6
    Customized:
     lentivirus for stable overexpression of GRM6
     lentivirus expression plasmids for stable overexpression of GRM6
     adenovirus for overexpression of GRM6
     LSBio Antibodies in human, mouse, rat for GRM6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRM6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4