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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRM5 Gene

protein-coding   GIFtS: 69
GCID: GC11M088237

glutamate receptor, metabotropic 5
 Explore 36 diseases affiliated with
GRM5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GRM5    

Aliases
for GRM5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutamate Receptor, Metabotropic 51 2     Metabotropic Glutamate Receptor 5 Variant F2
GPRC1E1 2 3     Metabotropic Glutamate Receptor 5 Variant G2
MGLUR51 2 3     Metabotropic Glutamate Receptor 5 Variant H2
MGlu51     MGluR51
Metabotropic Glutamate Receptor 52     

External Ids:    HGNC: 45971   Entrez Gene: 29152   Ensembl: ENSG000001689597   OMIM: 6041025   UniProtKB: P415943   

Export aliases for GRM5 gene to outside databases

Previous GC identifers: GC11M090564 GC11M089787 GC11M088425 GC11M087929 GC11M087881 GC11M084476


Summaries
for GRM5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GRM5:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function
and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G
protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal
transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been
shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.
Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist
selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: GRM5_HUMAN, P41594
Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a
phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current

summary for GRM5:
Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are
divided into two subtypes, mGlu1 and mGlu5. The receptors are coupled to Gq/11 which activates phospholipase
C and they are also associated with Na+ and K+ channels. Their action is generally excitatory, increasing
conductance, causing more glutamate to be released from the presynaptic cell. They can also increase
inhibitory postsynaptic potentials (IPSPs), inhibit glutamate release and can modulate voltage-dependent
calcium channels. Group I mGluRs, unlike other groups, are activated by 3,5-dihydroxyphenylglycine (DHPG),
allowing their function to be isolated. The human genes for mGlu1 and mGlu5 receptors have been localized to
chromosomes 6 (6q24) and 11 (11q14.3) respectively.

Gene Wiki entry for GRM5 (Metabotropic glutamate receptor 5)


Genomic Views
for GRM5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRM5 gene promoter:
         Max1   Sox5   AML1a   Pax-5   FOXF2   AP-1   Nkx2-5   POU3F2   FOXL1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GRM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3

GRM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M088237:  view genomic region     (about GC identifiers)

Start:
 88,237,744 bp from pter      End:
 88,799,113 bp from pter
Size:
 561,370 bases      Orientation:
 minus strand

Proteins
for GRM5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GRM5_HUMAN, P41594 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 5 precursor  
Size: 1212 amino acids; 132469 Da
Subunit: The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and
GRASP. Interacts with NCDN (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for GRM5:
3LMK (3D)    
Alternative splicing: 2 isoforms:  P41594-1   P41594-2   

Explore the universe of human proteins at neXtProt for GRM5: NX_P41594

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41594

    • GRM5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000833.1  NP_001137303.1  

    ENSEMBL proteins: 
     ENSP00000305905   ENSP00000306138   ENSP00000376975   ENSP00000403724   ENSP00000376972  
     ENSP00000402912   ENSP00000405690  
    Reactome Protein details: P41594
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: GRM5
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    Novus Biologicals GRM5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GRM5

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7908515
    GO:0014069postsynaptic density IEA--


    GRM5 for ontologies           About GeneDecksing



    GRM5 Antibody Products: 
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    Uscn ELISAs and CLIAs for GRM5

    Protein Domains /
    Families
    for GRM5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GRM5 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011500 GPCR_3_9-Cys_dom
     IPR000337 GPCR_3
     IPR000202 GPCR_3_mtglu_rcpt_5
     IPR017979 GPCR_3_CS
     IPR019588 Metabotropic_Glu_rcpt_Homer-bd

    Graphical View of Domain Structure for InterPro Entry P41594

    ProtoNet protein and cluster: P41594

    4 Blocks protein families:
    IPB000162 Metabotropic glutamate receptor signature
    IPB000202 Metabotropic glutamate receptor 5 signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM5_HUMAN, P41594
    Similarity: Belongs to the G-protein coupled receptor 3 family


    Function
    for GRM5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GRM5_HUMAN, P41594
    Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a
    phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current

         Genatlas biochemistry entry for GRM5:
    glutamate receptor group I,metabotropic 5,expressed in brain,most strongly in hippocampus,G protein coupled receptor
    superfamily,binding to HOMER proteins and linked to inositol phosphate receptors,activating PI turnover and triggering
    intracellular calcium release

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRM5
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate GRM5 (see all 97):
    hsa-miR-549 hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-376b hsa-miR-128 hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: GRM5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRM5 (see all 7)
    OriGene shRNA RFP: GRM5
    Browse OriGene siRNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GRM5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRM5 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): GRM5 (NM_000842)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM5
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    Cell Line
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    Search LifeMap BioReagents cell lines for GRM5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM5

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS7908515
    GO:0005515protein binding ----
    GO:0008066glutamate receptor activity TAS7908515
    GO:0031687A2A adenosine receptor binding IEA--


    GRM5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for GRM5:
     Decreased viability of wild-ty  Increased circadian period len 

    Animal Models:
         Mouse knock-outs for GRM5: Grm5tm1Fcq Grm5tm1Rod Grm5tm1.2Jixu
         7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Grm5):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  integument 
     nervous system  reproductive system 

    GRM5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GRM5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class C/3 (Metabotropic glutamate/pheromone receptors)
    		Class C/3 (Metabotropic glutamate/pheromone receptors)1.00
    		Synaptic Neurotransmission: Glutamatergic Excitation0.33
    		GPCRs, Class C Metabotropic glutamate, pheromone0.58
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    3Signaling in Gap Junctions
    		Signaling in Gap Junctions1.00
    		Gap junction0.31
    4Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    5Glutamic acid signaling
    		Glutamic acid signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GRM5
        Glutamic acid signaling

    2 R&D Systems Pathways for GRM5
        Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: GABAergic Inhibition

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRM5
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Huntington's Disease Pathway
    Signaling in Gap Junctions

    2 BioSystems Pathways for GRM5 
        Hypothetical Network for Drug Addiction
    GPCRs, Class C Metabotropic glutamate, pheromone

    4        Reactome Pathways for GRM5
        Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    GPCR ligand binding


    5/7         Kegg Pathways  (Kegg details for GRM5) (see all 7):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Long-term potentiation
    Glutamatergic synapse


    GRM5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/22 Interacting proteins for GRM5 (P415943 ENSP000003061384) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    HOMER1Q86YM73, ENSP000003343824I2D: score=5 STRING: ENSP00000334382
    GRASPQ7Z6J23, ENSP000002936624I2D: score=3 STRING: ENSP00000293662
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IEA--
    GO:0002029desensitization of G-protein coupled receptor protein signaling pathway IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation IEA--
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--


    GRM5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GRM5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRM5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for GRM5

    Compounds for GRM5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FenobamPotent and selective mGlu5 antagonist[57653-26-6]
    CDPPBPositive allosteric modulator at mGlu5[781652-57-1]
    MTEP hydrochloride Potent, selective mGlu5 antagonist --
    SIB 1757Highly selective mGlu5 antagonist[31993-01-8]
    VU 1545mGlu5 positive allosteric modulator[890764-63-3]

    2 HMDB Compounds for GRM5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--

    1 DrugBank Compound for GRM5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Acamprosate3-(Acetylamino)propanesulphonic acid (see all 3)77337-76-9targetantagonist15963001

    10/32 Novoseek chemical compound relationships for GRM5 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-methyl-6-(phenylethynyl)pyridine 94 55 19515968 (4), 18056795 (2), 14747613 (1), 16155210 (1) (see all 24)
    glutamate 88.9 439 15608073 (4), 19840937 (4), 14747613 (3), 16155210 (3) (see all 99)
    chpg 81.7 3 15733336 (1), 10428410 (1), 12660307 (1)
    ly367385 80.4 2 11414795 (1), 14529950 (1)
    nmda 67.8 62 10195215 (4), 16699816 (3), 12421605 (3), 20043967 (3) (see all 28)
    cpccoet 66.5 1 11414795 (1)
    quisqualate 65.2 3 14747613 (1), 15608073 (1), 12920211 (1)
    ganciclovir 60.2 5 17143482 (1), 7472317 (1), 16023154 (1), 12421605 (1) (see all 5)
    mcpg 59.2 1 17287348 (1)
    phencyclidine 53.8 4 15381829 (1), 12660307 (1)

    Search CenterWatch for drugs/clinical trials and news about GRM5 

    Transcripts
    for GRM5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GRM5 gene (2 alternative transcripts): 
    NM_000842.3  NM_001143831.2  

    Unigene Clusters for GRM5:

    Glutamate receptor, metabotropic 5
    Hs.147361  [show with all ESTs], Hs.616625  [show with all ESTs]
    Unigene Representative Sequences: NM_000842, NR_049724
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305432 ENST00000305447 ENST00000393297 ENST00000449371 ENST00000393294(uc009yvn.2)
    ENST00000418177(uc001pcq.3) ENST00000455756(uc009yvm.3)

    miRNA
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    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate GRM5 (see all 97):
    hsa-miR-549 hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-376b hsa-miR-128 hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: GRM5 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRM5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRM5

    Additional cDNA sequence: 

    AF052171.1 BC047497.1 NR_049724.1 U79242.1 

    8 DOTS entries:

    DT.446659  DT.92418277  DT.101973629  DT.95158624  DT.102827309  DT.65287414  DT.40124706  DT.95291084 

    24/70 AceView cDNA sequences (see all 70):

    Z42999 Z39706 U79242 AY608336 AF052171 F04277 Z39793 Z43739 
    Z43643 AW297388 F10870 AI379760 BX109548 S64316 R45014 AA332709 
    BC031602 Z39799 BI461222 BC047497 AI188170 AI201184 D60132 F01759 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GRM5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                                              -         
    SP3:                                                                        


    ECgene alternative splicing isoforms for GRM5

    Expression
    for GRM5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTACTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GRM5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType2 Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType3a Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType3b Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType4 Off Cone Bipolar CellsBipolar, Retina
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GRM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRM5

    SOURCE GeneReport for Unigene clusters: Hs.147361 Hs.616625
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRM5 (see all 6): 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for GRM5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GRM5 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GRM51 glutamate receptor, metabotropic 5 79.05(n)
    89.42(a)    		   373933  NM_204138.1  NP_989469.1 
    lizard
    (Anolis carolinensis)    		 Reptilia GRM56
    		 --
    		 92(a)
    		 1 ↔ 1
    		 3(199188999-199417957)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003329131 metabotropic glutamate receptor 5-like 70.16(n)
    77.1(a)    		   100332913  XM_002664719.2  XP_002664765.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG303613 metabotropic glutamate receptor signaling
    pathway metabotropic glutamate, GABA-B-like
    receptor less    		 41(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mgl-13 metatrophic glutamate receptor 36(a)   X(10003865-10009638)   --


    ENSEMBL Gene Tree for GRM5 (if available)
    TreeFam Gene Tree for GRM5 (if available) 

    Paralogs
    for GRM5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRM5 gene
    GRM72  GRM42  GRM62  GRM82  GRM22  GRM32  GRM12  
    10 SIMAP similar genes for GRM5 using alignment to 8 protein entries:     GRM5_HUMAN (see all proteins):
    GRM1    GRM3    GRM8    GRM7    GRM4    DKFZp686H1993
    GRM6    GRM2    GPCR    CASR

    GRM5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GRM5
    PGOHUM00000242688 PGOHUM00000257876


    Genomic Variants
    for GRM5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11083 NCBI SNPs in GRM5 are shown (see all 11083)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1385651721,2
    		--88237246(+) AACTTC/TTTTTT 3 -- us2k1 ds50010--------
    rs1904710931,2
    		--88237295(+) CACAAA/GCACAC 3 -- ds5001 us2k10--------
    rs1411965641,2
    		--88237406(+) TATCTA/GTGTGA 3 -- ds5001 us2k10--------
    rs558160401,2
    		C,--88237471(+) TAGATG/ACATAA 3 -- ds5001 us2k16Minor allele frequency- A:0.16WA NA CSA EA 363
    rs1170461671,2
    		--88237533(+) GTTTGT/CAGATG 3 -- us2k1 ds50011Minor allele frequency- C:0.01NA 120
    rs1162902651,2
    		F,--88237602(+) ATACAG/ATCCAC 3 -- ds5001 us2k11Minor allele frequency- A:0.05WA 118
    rs1159813811,2
    		--88237605(+) CAGTCC/TACTGC 3 -- us2k1 ds50010--------
    rs110201391,2
    		C,F,H,--88237649(+) ATCATC/GCAGTA 3 -- ds5001 us2k115Minor allele frequency- G:0.09NS EA NA 2024
    rs1175700661,2
    		F,--88237752(+) TATTAT/GAGGTT 3 -- nc-transcript-variantut311Minor allele frequency- G:0.02EA 120
    rs1836136751,2
    		--88237874(+) ACAAGG/TACAAA 3 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for GRM5 (88237744 - 88487744 bp, first 250kb of GRM5)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for GRM5
         9 CNVs: 6950 3861 6951 9193 5638 48912 71359 6949 30562
         2 Indels: 48913 101291
    Human Gene Mutation Database (HGMD): GRM5

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    DNA2.0 Custom Variant and Variant Library Synthesis for GRM5

    Disorders / Diseases
    for GRM5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GRM5 for disorders           About GeneDecksing

    OMIM gene information: 604102    OMIM disorders: --

    20/36 diseases for GRM5 (see all 36):    About MalaCards
    fragile x syndrome    focal cortical dysplasia    epilepsies, partial    temporal lobe epilepsy
    gastroesophageal reflux disease    status epilepticus    corpus callosum    intractable epilepsy
    amyotrophic lateral sclerosis    toxic encephalopathy    oral squamous cell carcinoma    lateral sclerosis
    gliosis    anorexia nervosa    intellectual disability    squamous cell carcinoma
    alcohol dependence    neurodegenerative disease    ganglioglioma    parkinson's disease

    7 diseases from the University of Copenhagen DISEASES database for GRM5:
    Fragile X syndrome     Schizophrenia     Parkinson's disease     Autistic disorder
    Intellectual disability     Gastroesophageal reflux disease     Toxic encephalopathy

    10/18 Novoseek disease relationships for GRM5 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fragile x syndrome 62.9 8 18202092 (2), 19117905 (2), 19017149 (1), 17987523 (1)
    cns diseases 50.3 8 19445453 (2), 18769310 (1), 16451073 (1)
    neurodegenerative diseases 44.9 4 17127176 (1), 10668448 (1), 17979788 (1)
    schizophrenia 43.6 20 16699816 (1), 19832691 (1), 19058862 (1), 17633521 (1) (see all 12)
    hypofunction 38.5 1 16719816 (1)
    parkinson disease 32.3 7 20132464 (1), 18769310 (1), 17979788 (1)
    drug addiction 31 2 15582465 (1)
    mental retardation 30.8 3 19445453 (1), 18202092 (1)
    epilepsy 27.2 1 10797615 (1)
    neurological disorders 21.5 10 17787003 (2), 17268022 (1), 17987523 (1), 15582465 (1)

    Genetic Association Database (GAD): GRM5
    Human Genome Epidemiology (HuGE) Navigator: GRM5 (11 documents)

    Export disorders for GRM5 gene to outside databases

    Publications
    for GRM5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRM5 gene, integrated from 9 sources (see all 300):
    (articles sorted by number of sources associating them with GRM5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5. (PubMed id 7908515)1, 2, 3, 9 Minakami R.... Sugiyama H. (1994)
    2. A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon. (PubMed id 7688218)1, 2, 9 Minakami R.... Sugiyama H. (1993)
    3. The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia. (PubMed id 11326300)1, 4 Devon R.S....Porteous D.J. (2001)
    4. Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction. (PubMed id 18991960)1, 9 Carroll F.I. (2008)
    5. Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB. (PubMed id 17998106)1, 9 Patel S....Gibson R.E. (2007)
    6. Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene. (PubMed id 12531512)1, 9 Bates B....Paulsen J.E. (2002)
    7. Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. (PubMed id 12783878)1, 9 Corti C....Ferraguti F. (2003)
    8. Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro. (PubMed id 9242710)1, 9 Minakami R....Sugiyama H. (1997)
    9. Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations. (PubMed id 15894802)1, 9 Kim C.H....Roche K.W. (2005)
    10. Regulation of the mGluR5, EAAT1 and GS expression by glucocorticoids in MG-63 osteoblast-like osteosarcoma cells. (PubMed id 17627080)1, 9 Kalariti N....Koutsilieris M. (2007)

    External Searches for GRM5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GRM5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2915 HGNC: 4597 AceView: GRM5 Ensembl:ENSG00000168959 euGenes: HUgn2915
    ECgene: GRM5 Kegg: 2915 H-InvDB: GRM5

    Other Databases showing GRM5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GRM5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRM5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GRM5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GRM5 gene:
    Search GeneIP for patents involving GRM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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