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Aliases for GRM5 Gene

Aliases for GRM5 Gene

  • Glutamate Receptor, Metabotropic 5 2 3
  • MGLUR5 3 4 6
  • GPRC1E 3 4
  • Protein Phosphatase 1, Regulatory Subunit 86 3
  • Metabotropic Glutamate Receptor 5 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 86 2
  • PPP1R86 3
  • MGlu5 3

External Ids for GRM5 Gene

Previous GeneCards Identifiers for GRM5 Gene

  • GC11M090564
  • GC11M089787
  • GC11M087929
  • GC11M087881
  • GC11M088237
  • GC11M084476

Summaries for GRM5 Gene

Entrez Gene Summary for GRM5 Gene

  • This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for GRM5 Gene

GRM5 (Glutamate Receptor, Metabotropic 5) is a Protein Coding gene. Diseases associated with GRM5 include synucleinopathy and fragile x syndrome. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and A2A adenosine receptor binding. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for GRM5 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

Tocris Summary for GRM5 Gene

  • Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are divided into two subtypes, mGlu1 and mGlu5. The receptors are coupled to Gq/11 which activates phospholipase C and they are also associated with Na+ and K+ channels. Their action is generally excitatory, increasing conductance, causing more glutamate to be released from the presynaptic cell. They can also increase inhibitory postsynaptic potentials (IPSPs), inhibit glutamate release and can modulate voltage-dependent calcium channels. Group I mGluRs, unlike other groups, are activated by 3,5-dihydroxyphenylglycine (DHPG), allowing their function to be isolated. The human genes for mGlu1 and mGlu5 receptors have been localized to chromosomes 6 (6q24) and 11 (11q14.3) respectively.

Gene Wiki entry for GRM5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM5 Gene

Genomics for GRM5 Gene

Regulatory Elements for GRM5 Gene

Genomic Location for GRM5 Gene

Start:
88,504,088 bp from pter
End:
89,113,519 bp from pter
Size:
609,432 bases
Orientation:
Minus strand

Genomic View for GRM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM5 Gene

Proteins for GRM5 Gene

  • Protein details for GRM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41594-GRM5_HUMAN
    Recommended name:
    Metabotropic glutamate receptor 5
    Protein Accession:
    P41594
    Secondary Accessions:
    • Q6J164

    Protein attributes for GRM5 Gene

    Size:
    1212 amino acids
    Molecular mass:
    132469 Da
    Quaternary structure:
    • The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRM5 Gene

    Alternative splice isoforms for GRM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRM5 Gene

Proteomics data for GRM5 Gene at MOPED

Post-translational modifications for GRM5 Gene

  • Glycosylation at Asn88, Asn210, Asn378, Asn382, Asn445, and Asn734
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM5 Gene

No data available for DME Specific Peptides for GRM5 Gene

Domains for GRM5 Gene

Gene Families for GRM5 Gene

HGNC:
  • GRM :GPCR / Class C : Glutamate receptors, metabotropic
  • GR :Glutamate receptors
IUPHAR :

Suggested Antigen Peptide Sequences for GRM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41594

UniProtKB/Swiss-Prot:

GRM5_HUMAN :
  • P41594
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM5: view

Function for GRM5 Gene

Molecular function for GRM5 Gene

GENATLAS Biochemistry: glutamate receptor group I,metabotropic 5,expressed in brain,most strongly in hippocampus,G protein coupled receptor superfamily,binding to HOMER proteins and linked to inositol phosphate receptors,activating PI turnover and triggering intracellular calcium release
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

Gene Ontology (GO) - Molecular Function for GRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IMP 7908515
GO:0005515 protein binding --
GO:0008066 glutamate receptor activity IDA 7908515
GO:0031687 A2A adenosine receptor binding IEA --
genes like me logo Genes that share ontologies with GRM5: view
genes like me logo Genes that share phenotypes with GRM5: view

Animal Models for GRM5 Gene

MGI Knock Outs for GRM5:

miRNA for GRM5 Gene

miRTarBase miRNAs that target GRM5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRM5 Gene

Localization for GRM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRM5 Gene COMPARTMENTS Subcellular localization image for GRM5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for GRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 7908515
GO:0014069 postsynaptic density IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with GRM5: view

Pathways for GRM5 Gene

genes like me logo Genes that share pathways with GRM5: view

Gene Ontology (GO) - Biological Process for GRM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IEA --
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with GRM5: view

Compounds for GRM5 Gene

(5) Tocris Compounds for GRM5 Gene

Compound Action Cas Number
(RS)-3,5-DHPG Selective group I mGlu agonist [19641-83-9]
(S)-3,5-DHPG Selective group I mGlu agonist. Active enantiomer of 3,5-DHPG (Cat. No. 0342) [162870-29-3]
FTIDC Potent and selective negative allosteric modulator at mGlu1; also mGlu1 inverse agonist [873551-53-2]
JNJ 16259685 Extremely potent, mGlu1-selective non-competitive antagonist [409345-29-5]
MPEP hydrochloride mGlu5 antagonist and positive allosteric modulator at mGlu4 [219911-35-0]

(2) HMDB Compounds for GRM5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Chlorine
  • Cl2
16887-00-6

(2) Drugbank Compounds for GRM5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acamprosate
  • 3-(Acetylamino)propanesulphonic acid
77337-76-9 target antagonist
Rufinamide
  • CGP 33101
106308-44-5 target inhibitor

(17) IUPHAR Ligand for GRM5 Gene

Ligand Type Action Affinity Pubmed IDs
MTEB Allosteric regulator Negative 8.7
BOMA Allosteric regulator Negative 8.5
DFB Allosteric regulator Positive 8.5
[3H]M-MPEP Allosteric regulator Negative 8.4
VU-1545 Allosteric regulator Positive 8
CDPPB Allosteric regulator Positive 8
MTEP Allosteric regulator Negative 7.8
[3H]fenobam Allosteric regulator Negative 7.5
fenobam Allosteric regulator Negative 7.2
PTeB Allosteric regulator Negative 7.2
ACDPP Antagonist Antagonist 6.9
SIB-1893 Allosteric regulator Positive 6.8
MPEP Allosteric regulator Positive 6.6
SIB-1757 Allosteric regulator Negative 6.4
CPPHA Allosteric regulator Positive 6.3
LY341495 Antagonist Antagonist 4.7
CHPG Agonist Full agonist 3.4

(32) Novoseek inferred chemical compound relationships for GRM5 Gene

Compound -log(P) Hits PubMed IDs
2-methyl-6-(phenylethynyl)pyridine 94 28
glutamate 88.9 172
chpg 81.7 3
ly367385 80.4 2
nmda 67.8 42
genes like me logo Genes that share compounds with GRM5: view

Transcripts for GRM5 Gene

Unigene Clusters for GRM5 Gene

Glutamate receptor, metabotropic 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRM5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: -
SP3:

Relevant External Links for GRM5 Gene

GeneLoc Exon Structure for
GRM5
ECgene alternative splicing isoforms for
GRM5

Expression for GRM5 Gene

mRNA expression in normal human tissues for GRM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.2), Brain - Anterior cingulate cortex (BA24) (6.8), Brain - Nucleus accumbens (basal ganglia) (6.4), Brain - Caudate (basal ganglia) (5.8), Brain - Cortex (5.6), Brain - Putamen (basal ganglia) (5.0), and Brain - Hippocampus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRM5 Gene

SOURCE GeneReport for Unigene cluster for GRM5 Gene Hs.147361

genes like me logo Genes that share expressions with GRM5: view

No data available for mRNA Expression by UniProt/SwissProt for GRM5 Gene

Orthologs for GRM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRM5 35
  • 99.69 (n)
  • 99.92 (a)
GRM5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRM5 35
  • 87.87 (n)
  • 92.99 (a)
GRM5 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRM5 35
  • 92.42 (n)
  • 95.75 (a)
GRM5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grm5 35
  • 89.14 (n)
  • 95.21 (a)
Grm5 16
Grm5 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRM5 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRM5 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grm5 35
  • 87.63 (n)
  • 94.82 (a)
chicken
(Gallus gallus)
Aves GRM5 35
  • 78.95 (n)
  • 89.4 (a)
GRM5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRM5 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grm5 35
  • 75.36 (n)
  • 84.17 (a)
zebrafish
(Danio rerio)
Actinopterygii GRM5 (1 of 2) 36
  • 72 (a)
OneToMany
GRM5 (2 of 2) 36
  • 73 (a)
OneToMany
LOC100332913 35
  • 70.27 (n)
  • 77.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30361 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea mgl-2 36
  • 37 (a)
OneToMany
mgl-1 37
  • 36 (a)
Species with no ortholog for GRM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM5 Gene

ENSEMBL:
Gene Tree for GRM5 (if available)
TreeFam:
Gene Tree for GRM5 (if available)

Paralogs for GRM5 Gene

Paralogs for GRM5 Gene

Selected SIMAP similar genes for GRM5 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for GRM5 Gene

genes like me logo Genes that share paralogs with GRM5: view

Variants for GRM5 Gene

Sequence variations from dbSNP and Humsavar for GRM5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3337 -- 88,601,853(-) GGTGA(A/G)TAGAA intron-variant
rs149461 -- 88,549,437(-) tttga(A/G)acaag intron-variant
rs150769 -- 88,531,607(+) ATAGA(A/T)ATTGC intron-variant
rs160195 -- 88,559,805(+) GCGAG(G/T)CTAGA intron-variant
rs160196 -- 88,533,225(-) agtga(C/G)ttttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRM5 Gene

Variant ID Type Subtype PubMed ID
esv270366 CNV Insertion 20981092
nsv507606 CNV Insertion 20534489
nsv510266 CNV Loss 20534489
nsv425 CNV Insertion 18451855
nsv526075 CNV Loss 19592680
nsv468780 CNV Loss 19166990
nsv516008 CNV Loss 19592680
esv2751036 CNV Loss 17911159
esv274059 CNV Insertion 20981092
esv271657 CNV Insertion 20981092
nsv38884 CNV Loss 16902084
esv2608798 CNV Insertion 19546169
esv1705083 CNV Insertion 17803354
dgv411e1 CNV Complex 17122850
nsv898084 CNV Loss 21882294
dgv78n21 CNV Gain 19592680
essv12691 CNV CNV 17122850
nsv8853 CNV Gain 18304495
esv22440 CNV Gain 19812545
esv33207 CNV Gain 17666407
esv33258 CNV Loss 17666407
esv2744875 CNV Deletion 23290073
esv2744876 CNV Deletion 23290073
esv32702 CNV Gain+Loss 17666407
dgv1253n71 CNV Loss 21882294
nsv898087 CNV Loss 21882294
esv2744877 CNV Deletion 23290073
esv2744878 CNV Deletion 23290073
esv2744879 CNV Deletion 23290073

Relevant External Links for GRM5 Gene

HapMap Linkage Disequilibrium report
GRM5
Human Gene Mutation Database (HGMD)
GRM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM5 Gene

Disorders for GRM5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for GRM5 Gene including...

Search for GRM5 Gene in MalaCards »

(18) Novoseek inferred disease relationships for GRM5 Gene

Disease -log(P) Hits PubMed IDs
fragile x syndrome 62.9 6
cns diseases 50.3 4
neurodegenerative diseases 44.9 3
schizophrenia 43.6 12
hypofunction 38.5 1

Relevant External Links for GRM5

Genetic Association Database (GAD)
GRM5
Human Genome Epidemiology (HuGE) Navigator
GRM5
genes like me logo Genes that share disorders with GRM5: view

No data available for UniProtKB/Swiss-Prot for GRM5 Gene

Publications for GRM5 Gene

  1. Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5. (PMID: 7908515) Minakami R. … Sugiyama H. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon. (PMID: 7688218) Minakami R. … Sugiyama H. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  3. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 48
  4. Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. (PMID: 12783878) Corti C. … Ferraguti F. (J. Biol. Chem. 2003) 3 23
  5. Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. (PMID: 12786977) Aronica E. … Troost D. (Eur. J. Neurosci. 2003) 3 23

Products for GRM5 Gene

Sources for GRM5 Gene

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