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GRM5 Gene

protein-coding   GIFtS: 69
GCID: GC11M088237

Glutamate Receptor, Metabotropic 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Metabotropic 51 2     Metabotropic Glutamate Receptor 52
MGLUR52 3 5     Metabotropic Glutamate Receptor 5 Variant F2
GPRC1E2 3     Metabotropic Glutamate Receptor 5 Variant G2
GRM5 Variant 92     Metabotropic Glutamate Receptor 5 Variant H2
mGlu52     mGluR53

External Ids:    HGNC: 45971   Entrez Gene: 29152   Ensembl: ENSG000001689597   OMIM: 6041025   UniProtKB: P415943   

Export aliases for GRM5 gene to outside databases

Previous GC identifers: GC11M090564 GC11M089787 GC11M088425 GC11M087929 GC11M087881 GC11M084476


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRM5 Gene:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic
and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain
function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a
family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology,
putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes
GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but
differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for GRM5 Gene:
GRM5 (glutamate receptor, metabotropic 5) is a protein-coding gene. Diseases associated with GRM5 include fragile x syndrome, and drug addiction. GO annotations related to this gene include G-protein coupled receptor activity and A2A adenosine receptor binding. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GRM5_HUMAN, P41594
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a
calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the
modulation of the neural network activity

summary for GRM5 Gene:
Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are
divided into two subtypes, mGlu1 and mGlu5. The receptors are coupled to Gq/11 which activates phospholipase
C and they are also associated with Na+ and K+ channels. Their action is generally excitatory, increasing
conductance, causing more glutamate to be released from the presynaptic cell. They can also increase
inhibitory postsynaptic potentials (IPSPs), inhibit glutamate release and can modulate voltage-dependent
calcium channels. Group I mGluRs, unlike other groups, are activated by 3,5-dihydroxyphenylglycine (DHPG),
allowing their function to be isolated. The human genes for mGlu1 and mGlu5 receptors have been localized to
chromosomes 6 (6q24) and 11 (11q14.3) respectively.

Gene Wiki entry for GRM5 (Metabotropic glutamate receptor 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRM5 gene promoter:
         Max1   Sox5   AML1a   Pax-5   FOXF2   AP-1   Nkx2-5   POU3F2   FOXL1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRM5 promoter sequence
   Search Chromatin IP Primers for GRM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3

GRM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M088237:  view genomic region     (about GC identifiers)

Start:
88,237,744 bp from pter      End:
88,799,113 bp from pter
Size:
561,370 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRM5_HUMAN, P41594 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 5 precursor  
Size: 1212 amino acids; 132469 Da
Subunit: The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3
and GRASP. Interacts with NCDN (By similarity)
1 PDB 3D structure from and Proteopedia for GRM5:
3LMK (3D)    
Secondary accessions: Q6J164
Alternative splicing: 3 isoforms:  P41594-1   P41594-2   P41594-3   

Explore the universe of human proteins at neXtProt for GRM5: NX_P41594

Explore proteomics data for GRM5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn88, Asn210, Asn378, Asn382, Asn445, Asn734
  • Modification sites at PhosphoSitePlus

  • See GRM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000833.1  NP_001137303.1  

    ENSEMBL proteins: 
     ENSP00000305905   ENSP00000306138   ENSP00000376975   ENSP00000403724   ENSP00000376972  
     ENSP00000402912   ENSP00000405690  
    Reactome Protein details: P41594

    GRM5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRM5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRM5
    GenScript Custom Purified and Recombinant Proteins Services for GRM5
    Novus Biologicals GRM5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRM5

    GRM5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRM5
    R&D Systems Antibodies for GRM5 (mGluR5)
    OriGene Antibodies for GRM5
    OriGene Custom Antibody Services for GRM5
    Novus Biologicals GRM5 Antibodies
    Abcam antibodies for GRM5
    Cloud-Clone Corp. Antibodies for GRM5
    ThermoFisher Antibodies for GRM5
    LSBio Antibodies in human, mouse, rat for GRM5

    GRM5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRM5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRM5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRM5
    Cloud-Clone Corp. CLIAs for GRM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GR: Glutamate receptors
    GRM: GPCR / Class C : Glutamate receptors, metabotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: mGlu5 receptor
    Metabotropic glutamate receptors

    Selected InterPro protein domains (see all 9):
     IPR011500 GPCR_3_9-Cys_dom
     IPR028082 Peripla_BP_I
     IPR000337 GPCR_3
     IPR000202 GPCR_3_mtglu_rcpt_5
     IPR017979 GPCR_3_CS

    Graphical View of Domain Structure for InterPro Entry P41594

    ProtoNet protein and cluster: P41594

    4 Blocks protein domains:
    IPB000162 Metabotropic glutamate receptor signature
    IPB000202 Metabotropic glutamate receptor 5 signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM5_HUMAN, P41594
    Similarity: Belongs to the G-protein coupled receptor 3 family


    GRM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRM5_HUMAN, P41594
    Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
    signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
    effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a
    calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the
    modulation of the neural network activity

         Genatlas biochemistry entry for GRM5:
    glutamate receptor group I,metabotropic 5,expressed in brain,most strongly in hippocampus,G protein coupled
    receptor superfamily,binding to HOMER proteins and linked to inositol phosphate receptors,activating PI turnover
    and triggering intracellular calcium release

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS7908515
    GO:0005515protein binding ----
    GO:0008066glutamate receptor activity IDA7908515
    GO:0031687A2A adenosine receptor binding IEA--
         
    GRM5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for GRM5:
     Decreased viability of wild-ty  Increased circadian period len 

         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Grm5):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  integument 
     nervous system  reproductive system 

    GRM5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRM5: Grm5tm1Fcq Grm5tm1Rod Grm5tm1.2Jixu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRM5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRM5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRM5

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRM5:
    hsa-mir-335-5p (MIRT018632)

    Block miRNA regulation of human, mouse, rat GRM5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM5 (see all 97):
    hsa-miR-549 hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-376b hsa-miR-128 hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidGRM5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRM5
    Predesigned siRNA for gene silencing in human, mouse, rat GRM5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRM5

    Clone
    Products:
         
    OriGene clones in human, mouse for GRM5 (see all 13)
    OriGene ORF clones in mouse, rat for GRM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRM5 (NM_000842)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM5
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GRM5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRM5
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRM5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRM5_HUMAN, P41594: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP7908515
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane ----

    GRM5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRM5 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    3Glutamic acid signaling
    Glutamic acid signaling
    Synaptic Neurotransmission: Glutamatergic Excitation0.00
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for GRM5
        Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: GABAergic Inhibition

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRM5
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Huntington's Disease Pathway
    Signaling in Gap Junctions

    2 BioSystems Pathways for GRM5
        Hypothetical Network for Drug Addiction
    GPCRs, Class C Metabotropic glutamate, pheromone

    2 Reactome Pathways for GRM5
        G alpha (q) signalling events
    Class C/3 (Metabotropic glutamate/pheromone receptors)


    Selected Kegg Pathways  (Kegg details for GRM5) (see all 7):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Long-term potentiation
    Retrograde endocannabinoid signaling


    GRM5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM5 (see all 6): 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRM5 (P415943 ENSP000003061384) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    HOMER1Q86YM73, ENSP000003343824I2D: score=5 STRING: ENSP00000334382
    ADORA2AP292743, ENSP000003366304I2D: score=3 STRING: ENSP00000336630
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IEA--
    GO:0002029desensitization of G-protein coupled receptor protein signaling pathway IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----

    GRM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GRM5
      Browse compounds at ApexBio 

    Compounds for GRM5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 367385Selective mGlu1a antagonist[198419-91-9]
    MTEP hydrochloride Potent, selective mGlu5 antagonist [1186195-60-7]
    (RS)-3,5-DHPG Selective group I mGlu agonist[19641-83-9]
    MPEP hydrochloridemGlu5 antagonist and positive allosteric modulator at mGlu4[96206-92-7]
    (S)-3,5-DHPG Selective group I mGlu agonist. Active enantiomer of 3,5-DHPG (Cat. No. 0342) [162870-29-3]

    2 HMDB Compounds for GRM5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--

    2 DrugBank Compounds for GRM5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Acamprosate3-(Acetylamino)propanesulphonic acid (see all 4)77337-76-9targetantagonist15963001
    RufinamideCGP 33101 (see all 4)106308-44-5targetinhibitor21351809

    Selected IUPHAR Ligands for GRM5 (mGlu5 receptor) (see all 17)    About this table
    LigandTypeActionAffinityPubmed IDs
    MTEB
    Allosteric regulatorNegative8.714697765
    BOMA
    Allosteric regulatorNegative8.514697765
    DFB
    Allosteric regulatorPositive5.6 - 8.514747613 12920211
    [3H]M-MPEP
    Allosteric regulatorNegative8.411814808
    VU-1545
    Allosteric regulatorPositive816722652
    CDPPB
    Allosteric regulatorPositive7.6 - 815608073 15537338
    MTEP
    Allosteric regulatorNegative7.812473093
    MPEP
    Allosteric regulatorNegative7.4 - 7.711814808 10530811
    [3H]fenobam
    Allosteric regulatorNegative7.516040814
    fenobam
    Allosteric regulatorNegative7.216040814

    Selected Novoseek inferred chemical compound relationships for GRM5 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-methyl-6-(phenylethynyl)pyridine 94 55 19515968 (4), 18056795 (2), 14747613 (1), 16155210 (1) (see all 24)
    glutamate 88.9 439 15608073 (4), 19840937 (4), 14747613 (3), 16155210 (3) (see all 99)
    chpg 81.7 3 15733336 (1), 10428410 (1), 12660307 (1)
    ly367385 80.4 2 11414795 (1), 14529950 (1)
    nmda 67.8 62 10195215 (4), 16699816 (3), 12421605 (3), 20043967 (3) (see all 28)
    cpccoet 66.5 1 11414795 (1)
    quisqualate 65.2 3 14747613 (1), 15608073 (1), 12920211 (1)
    ganciclovir 60.2 5 17143482 (1), 7472317 (1), 16023154 (1), 12421605 (1) (see all 5)
    mcpg 59.2 1 17287348 (1)
    phencyclidine 53.8 4 15381829 (1), 12660307 (1)



    GRM5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRM5 gene (2 alternative transcripts): 
    NM_000842.3  NM_001143831.2  

    Unigene Clusters for GRM5:

    Glutamate receptor, metabotropic 5
    Hs.147361  [show with all ESTs], Hs.616625  [show with all ESTs]
    Unigene Representative Sequences: NM_000842, NR_049724
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305432 ENST00000305447 ENST00000393297 ENST00000449371 ENST00000393294(uc009yvn.2)
    ENST00000418177(uc001pcq.3) ENST00000455756(uc009yvm.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GRM5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM5 (see all 97):
    hsa-miR-549 hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-376b hsa-miR-128 hsa-miR-30d hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidGRM5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GRM5
    Predesigned siRNA for gene silencing in human, mouse, rat GRM5
    Clone
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    OriGene clones in human, mouse for GRM5 (see all 13)
    OriGene ORF clones in mouse, rat for GRM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRM5 (NM_000842)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM5
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GRM5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRM5
      QuantiTect SYBR Green Assays in human, mouse, rat GRM5
      QuantiFast Probe-based Assays in human, mouse, rat GRM5

    Additional mRNA sequence: 

    AF052171.1 BC047497.1 NR_049724.1 U79242.1 

    8 DOTS entries:

    DT.446659  DT.92418277  DT.101973629  DT.95158624  DT.102827309  DT.65287414  DT.40124706  DT.95291084 

    Selected AceView cDNA sequences (see all 70):

    Z43739 R45014 AF052171 AA332709 F10870 Z42999 F04277 Z39706 
    Z39799 BX109548 U79242 BC031602 Z39793 AW297388 S64316 AY608336 
    Z43643 AI379760 BF515205 D81109 BC047497 BE467680 T27142 AI188170 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GRM5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                                              -         
    SP3:                                                                        


    ECgene alternative splicing isoforms for GRM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTACTTGG
    GRM5 Expression
    About this image


    GRM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neurons
             Type3a Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Type3a Off Cone Bipolar Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Mature Endothelial Cells Blood Brain Barrier
             Medulla Oblongata
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Spinal Ventral Columns
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
    GRM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRM5 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.147361 Hs.616625
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM5 (see all 6): 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRM5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grm51 , 5 glutamate receptor, metabotropic 51, 5 89.14(n)1
    95.21(a)1
      7 (49.01 cM)5
    1080711  NM_001143834.11  NP_001137306.11 
     878038155 
    chicken
    (Gallus gallus)
    Aves GRM51 glutamate receptor, metabotropic 5 78.95(n)
    89.4(a)
      373933  NM_204138.1  NP_989469.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRM56
    glutamate receptor, metabotropic 5
    87(a)
    1 ↔ 1
    3(199188815-199427619)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grm51 glutamate receptor, metabotropic 5 75.36(n)
    84.17(a)
      100485273  XM_002936551.2  XP_002936597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003329131 metabotropic glutamate receptor 5-like 70.27(n)
    77.8(a)
      100332913  XM_002664719.3  XP_002664765.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mgl-13 metatrophic glutamate receptor 36(a)   X(10003865-10009638)   --


    ENSEMBL Gene Tree for GRM5 (if available)
    TreeFam Gene Tree for GRM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRM5 gene
    GRM72  GRM42  TAS1R22  GRM82  TAS1R32  GRM22  GRM32  TAS1R12  
    GRM62  GRM12  GPRC6A2  
    11 SIMAP similar genes for GRM5 using alignment to 7 protein entries:     GRM5_HUMAN (see all proteins):
    GRM1    GRM8    GRM3    GRM4    GRM7    GRM2
    DKFZp686H1993    GRM6    TAS1R1    GPCR    CASR

    GRM5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for GRM5
    PGOHUM00000242688 PGOHUM00000257876


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRM5 (see all 12109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890216501,2
    --85038079(+) TTAGCC/TCCAGC 1 -- us2k10--------
    rs1903662801,2
    --88257802(+) TCAATC/GAGGAG 2 -- int10--------
    rs1819577701,2
    --88257823(+) AAAAGA/GACATG 2 -- int10--------
    rs1996234241,2
    C--88257837(+) AGCACA/GGCGAC 2 -- int10--------
    rs116072001,2
    C,F,H--88257930(+) CAGTTT/CGAGAA 2 -- int113Minor allele frequency- C:0.06NS EA NA 1486
    rs1875016041,2
    --88257981(+) TTGCCC/TTTGGC 2 -- int10--------
    rs9737161,2
    C,F,O,A,H--88258182(+) GAACCG/ATTTGA 2 -- int125Minor allele frequency- A:0.09NS EA NA WA 2786
    rs1881116051,2
    --88258316(+) CATAGA/GTTTTG 2 -- int10--------
    rs1489706841,2
    C--88258362(+) GGGTTG/TGACAC 2 -- int10--------
    rs1809191331,2
    C--88258521(+) TTGGGA/GGTGAA 3 T int1 syn10--------

    HapMap Linkage Disequilibrium report for GRM5 (88237744 - 88487744 bp, first 250kb of GRM5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRM5 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744875CNV Deletion23290073
    esv2744878CNV Deletion23290073
    esv2744877CNV Deletion23290073
    esv2744879CNV Deletion23290073
    esv2744876CNV Deletion23290073
    nsv507606CNV Insertion20534489
    esv271657CNV Insertion20981092
    nsv425CNV Insertion18451855
    esv1705083CNV Insertion17803354
    esv270366CNV Insertion20981092

    Human Gene Mutation Database (HGMD): GRM5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRM5
    DNA2.0 Custom Variant and Variant Library Synthesis for GRM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604102    OMIM disorders: --

    Selected diseases for GRM5 (see all 33):    
    About MalaCards
    fragile x syndrome    drug addiction    ganglioglioma    gastroesophageal reflux disease
    status epilepticus    autistic disorder    toxic encephalopathy    attention deficit hyperactivity disorder
    albinism    traumatic brain injury    temporal lobe epilepsy    alcohol dependence
    parkinson's disease    anorexia nervosa    brain injury    intellectual disability
    schizophrenia    mental retardation    ischemia    lateral sclerosis

    7 diseases from the University of Copenhagen DISEASES database for GRM5:
    Fragile X syndrome     Schizophrenia     Parkinson's disease     Autistic disorder
    Intellectual disability     Gastroesophageal reflux disease     Toxic encephalopathy

    GRM5 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for GRM5 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fragile x syndrome 62.9 8 18202092 (2), 19117905 (2), 19017149 (1), 17987523 (1)
    cns diseases 50.3 8 19445453 (2), 18769310 (1), 16451073 (1)
    neurodegenerative diseases 44.9 4 17127176 (1), 10668448 (1), 17979788 (1)
    schizophrenia 43.6 20 16699816 (1), 19832691 (1), 19058862 (1), 17633521 (1) (see all 12)
    hypofunction 38.5 1 16719816 (1)
    parkinson disease 32.3 7 20132464 (1), 18769310 (1), 17979788 (1)
    drug addiction 31 2 15582465 (1)
    mental retardation 30.8 3 19445453 (1), 18202092 (1)
    epilepsy 27.2 1 10797615 (1)
    neurological disorders 21.5 10 17787003 (2), 17268022 (1), 17987523 (1), 15582465 (1)

    Genetic Association Database (GAD): GRM5
    Human Genome Epidemiology (HuGE) Navigator: GRM5 (11 documents)

    Export disorders for GRM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRM5 gene, integrated from 10 sources (see all 314):
    (articles sorted by number of sources associating them with GRM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5. (PubMed id 7908515)1, 2, 3, 9 Minakami R.... Sugiyama H. (Biochem. Biophys. Res. Commun. 1994)
    2. A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon. (PubMed id 7688218)1, 2, 9 Minakami R.... Sugiyama H. (Biochem. Biophys. Res. Commun. 1993)
    3. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. (PubMed id 22012869)1, 4 Hinney A....Hebebrand J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    9. Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)1, 4 Fellay J....Goldstein D.B. (PLoS Genet. 2009)
    10. Genome-wide association study of tanning phenotype in a population of European ancestry. (PubMed id 19340012)1, 4 Nan H....Han J. (J. Invest. Dermatol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2915 HGNC: 4597 AceView: GRM5 Ensembl:ENSG00000168959 euGenes: HUgn2915
    ECgene: GRM5 Kegg: 2915 H-InvDB: GRM5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GRM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRM5 gene:
    Search GeneIP for patents involving GRM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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