Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRM3 Gene

Aliases for GRM3 Gene

  • Glutamate Receptor, Metabotropic 3 2 3
  • GPRC1C 3 4
  • MGLUR3 3 4
  • Glutamate Metabotropic Receptor 3 3
  • GLUR3 3
  • MGlu3 3

External Ids for GRM3 Gene

Previous GeneCards Identifiers for GRM3 Gene

  • GC07P084809
  • GC07P085871
  • GC07P085886
  • GC07P085885
  • GC07P085917
  • GC07P086111
  • GC07P086274
  • GC07P080884

Summaries for GRM3 Gene

Entrez Gene Summary for GRM3 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM3 Gene

GRM3 (Glutamate Receptor, Metabotropic 3) is a Protein Coding gene. Diseases associated with GRM3 include schizophrenia. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for GRM3 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM3 Gene

  • Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.

Gene Wiki entry for GRM3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM3 Gene

Genomics for GRM3 Gene

Regulatory Elements for GRM3 Gene

Genomic Location for GRM3 Gene

Chromosome:
7
Start:
86,643,914 bp from pter
End:
86,864,884 bp from pter
Size:
220,971 bases
Orientation:
Plus strand

Genomic View for GRM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM3 Gene

Proteins for GRM3 Gene

  • Protein details for GRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14832-GRM3_HUMAN
    Recommended name:
    Metabotropic glutamate receptor 3
    Protein Accession:
    Q14832
    Secondary Accessions:
    • Q2PNZ6
    • Q75MV4
    • Q75N17
    • Q86YG6
    • Q8TBH9

    Protein attributes for GRM3 Gene

    Size:
    879 amino acids
    Molecular mass:
    98879 Da
    Quaternary structure:
    • Interacts with GRASP.
    SequenceCaution:
    • Sequence=AAD15616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRM3 Gene

    Alternative splice isoforms for GRM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRM3 Gene

Proteomics data for GRM3 Gene at MOPED

Post-translational modifications for GRM3 Gene

  • Glycosylation at Asn 209, Asn 292, Asn 414, and Asn 439
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM3 Gene

Antibody Products

No data available for DME Specific Peptides for GRM3 Gene

Domains & Families for GRM3 Gene

Gene Families for GRM3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14832

UniProtKB/Swiss-Prot:

GRM3_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM3: view

Function for GRM3 Gene

Molecular function for GRM3 Gene

GENATLAS Biochemistry:
metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP cascade
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001641 group II metabotropic glutamate receptor activity IBA --
GO:0001642 NOT group III metabotropic glutamate receptor activity IBA --
GO:0004930 G-protein coupled receptor activity TAS 8840013
GO:0005246 calcium channel regulator activity IEA --
GO:0008066 glutamate receptor activity TAS 8840013
genes like me logo Genes that share ontologies with GRM3: view
genes like me logo Genes that share phenotypes with GRM3: view

Animal Models for GRM3 Gene

MGI Knock Outs for GRM3:

Animal Model Products

miRNA for GRM3 Gene

miRTarBase miRNAs that target GRM3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRM3 Gene

Localization for GRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRM3 Gene COMPARTMENTS Subcellular localization image for GRM3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8840013
GO:0014069 postsynaptic density IEA --
GO:0016021 integral component of membrane --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with GRM3: view

Pathways & Interactions for GRM3 Gene

genes like me logo Genes that share pathways with GRM3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007194 negative regulation of adenylate cyclase activity TAS 8840013
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IBA --
GO:0007268 synaptic transmission TAS 8840013
GO:0051966 regulation of synaptic transmission, glutamatergic IBA --
genes like me logo Genes that share ontologies with GRM3: view

No data available for SIGNOR curated interactions for GRM3 Gene

Drugs & Compounds for GRM3 Gene

(29) Drugs for GRM3 Gene - From: NovoSeek, IUPHAR, PharmGKB, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heroin Approved, Illicit Pharma 106
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 579
Amphetamine Approved, Illicit Pharma 96
Ganciclovir Approved, Investigational Pharma 139
cyclic amp Experimental Pharma 0

(14) Additional Compounds for GRM3 Gene - From: Tocris and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1S,3R)-ACPD
111900-32-4
(S)-4-Carboxy-3-hydroxyphenylglycine
85148-82-9
(S)-MCPG
150145-89-4
L-CCG-l
117857-93-9
Xanthurenic acid
  • 4,8-Dihydroxy-2-quinolinecarboxylate
  • 4,8-Dihydroxy-2-quinolinecarboxylic acid
  • 4,8-Dihydroxy-Quinaldate
  • 4,8-Dihydroxy-Quinaldic acid
  • 4,8-Dihydroxyquinaldate
59-00-7
genes like me logo Genes that share compounds with GRM3: view

Transcripts for GRM3 Gene

Unigene Clusters for GRM3 Gene

Glutamate receptor, metabotropic 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRM3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for GRM3 Gene

GeneLoc Exon Structure for
GRM3
ECgene alternative splicing isoforms for
GRM3

Expression for GRM3 Gene

mRNA expression in normal human tissues for GRM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.7), Brain - Caudate (basal ganglia) (x6.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Spinal cord (cervical c-1) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GRM3 Gene

This gene is overexpressed in NK cells (36.3), Fetal Brain (13.8), Frontal cortex (12.4), and Pancreatic juice (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRM3 Gene



SOURCE GeneReport for Unigene cluster for GRM3 Gene Hs.590575

mRNA Expression by UniProt/SwissProt for GRM3 Gene

Q14832-GRM3_HUMAN
Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
genes like me logo Genes that share expression patterns with GRM3: view

Protein tissue co-expression partners for GRM3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRM3 35
  • 92.07 (n)
  • 97.27 (a)
GRM3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRM3 35
  • 92.03 (n)
  • 96.33 (a)
GRM3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grm3 35
  • 89.65 (n)
  • 96.7 (a)
Grm3 16
Grm3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRM3 35
  • 99.73 (n)
  • 99.66 (a)
GRM3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grm3 35
  • 89.95 (n)
  • 96.59 (a)
oppossum
(Monodelphis domestica)
Mammalia GRM3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRM3 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRM3 35
  • 79.98 (n)
  • 91.01 (a)
GRM3 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRM3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grm3 35
  • 74.07 (n)
  • 86.21 (a)
zebrafish
(Danio rerio)
Actinopterygii grm3 35
  • 71.31 (n)
  • 78.57 (a)
grm3 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30361 37
  • 39 (a)
Glu-RA 37
  • 49 (a)
mGluRA 35
  • 54.48 (n)
  • 53.15 (a)
mGluRA 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mgl-1 37
  • 41 (a)
mgl-1 35
  • 50.54 (n)
  • 45.11 (a)
mgl-1 36
  • 36 (a)
OneToMany
Species with no ortholog for GRM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM3 Gene

ENSEMBL:
Gene Tree for GRM3 (if available)
TreeFam:
Gene Tree for GRM3 (if available)

Paralogs for GRM3 Gene

Paralogs for GRM3 Gene

genes like me logo Genes that share paralogs with GRM3: view

Variants for GRM3 Gene

Sequence variations from dbSNP and Humsavar for GRM3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs17126 -- 86,842,597(+) GGTTC(A/G)GACAG intron-variant
rs166677 -- 86,642,978(+) TTGTA(C/T)GTGGT upstream-variant-2KB
rs274613 -- 86,647,495(+) CGCAC(A/G)CTGGA intron-variant
rs274614 -- 86,648,771(+) CACTT(A/G)AAATC intron-variant
rs274615 -- 86,649,621(+) TCAGT(A/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRM3 Gene

Variant ID Type Subtype PubMed ID
nsv888633 CNV Gain 21882294
nsv831053 CNV Gain 17160897
esv7104 CNV Gain 19470904
nsv824201 CNV Loss 20364138
esv269784 CNV Insertion 20981092
esv273882 CNV Insertion 20981092
esv2667611 CNV Deletion 23128226
esv271910 CNV Insertion 20981092
esv2504097 CNV Deletion 19546169

Variation tolerance for GRM3 Gene

Residual Variation Intolerance Score: 4.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRM3 Gene

HapMap Linkage Disequilibrium report
GRM3
Human Gene Mutation Database (HGMD)
GRM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM3 Gene

Disorders for GRM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRM3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association
Search GRM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRM3

Genetic Association Database (GAD)
GRM3
Human Genome Epidemiology (HuGE) Navigator
GRM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRM3
genes like me logo Genes that share disorders with GRM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM3 Gene

Publications for GRM3 Gene

  1. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PMID: 8824806) Scherer S.W. … Tsui L.C. (Genomics 1996) 2 23 67
  2. Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression. (PMID: 19945495) Feyissa A.M. … Karolewicz B. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 23 67
  3. Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR. (PMID: 19285517) Fricker A.C. … Kew J.N. (Neuropharmacology 2009) 23 67
  4. The glutamatergic system expression in human PC-3 and LNCaP prostate cancer cells. (PMID: 19331175) Pissimissis N. … Koutsilieris M. (Anticancer Res. 2009) 23 67
  5. Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA. (PMID: 19402024) LundstrAPm L. … Gatti S. (ChemMedChem 2009) 23 67

Products for GRM3 Gene

Sources for GRM3 Gene

Back to Top

Content