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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRM3 Gene

protein-coding   GIFtS: 68
GCID: GC07P086274

Glutamate Receptor, Metabotropic 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamate Receptor, Metabotropic 31 2     Glutamate Metabotropic Receptor 32
GPRC1C2 3     mGlu32
MGLUR32 3     Metabotropic Glutamate Receptor 32
GLUR32     mGluR33

External Ids:    HGNC: 45951   Entrez Gene: 29132   Ensembl: ENSG000001988227   OMIM: 6011155   UniProtKB: Q148323   

Export aliases for GRM3 gene to outside databases

Previous GC identifers: GC07P084809 GC07P085871 GC07P085886 GC07P085885 GC07P085917 GC07P086111 GC07P080884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRM3 Gene:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic
and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain
function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a
family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology,
putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes
GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but
differ in their agonist selectivities. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRM3 Gene: 
GRM3 (glutamate receptor, metabotropic 3) is a protein-coding gene. Diseases associated with GRM3 include hyperaldosteronism, and ganglioglioma, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and GPCRs, Class C Metabotropic glutamate, pheromone. GO annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
cyclase activity

summary for GRM3 Gene:
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided
into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o which inhibits adenylyl
cyclase, decreasing the formation of cAMP. mGlu group II receptors are involved in presynaptic inhibition
and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and
mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

Gene Wiki entry for GRM3 (Metabotropic glutamate receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRM3 gene promoter:
         CREB   Sox5   SRY   deltaCREB   HSF1 (long)   IRF-1   LCR-F1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GRM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1-q21.2   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.1-q21.2

GRM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086274:  view genomic region     (about GC identifiers)

Start:
86,273,230 bp from pter      End:
86,494,200 bp from pter
Size:
220,971 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 85,604,962-85,825,938     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 3 precursor  
Size: 879 amino acids; 98879 Da
Subunit: Interacts with GRASP (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAD15616.1; Type=Erroneous initiation; Sequence=CAA54796.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for GRM3:
1S8M (3D)        3SM9 (3D)    
Secondary accessions: Q75MV4 Q75N17 Q86YG6 Q8TBH9

Explore the universe of human proteins at neXtProt for GRM3: NX_Q14832

Explore proteomics data for GRM3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14832

  • GRM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRM3 Protein Expression
    REFSEQ proteins: NP_000831.2  
    ENSEMBL proteins: 
     ENSP00000355316   ENSP00000405427   ENSP00000398767   ENSP00000390037   ENSP00000407490  
     ENSP00000444064   ENSP00000441407   ENSP00000378209  
    Reactome Protein details: Q14832
    Human Recombinant Protein Products for GRM3: 
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    Novus Biologicals GRM3 Proteins
    Novus Biologicals GRM3 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRM3 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8840013
    GO:0014069postsynaptic density IEA--
    GO:0016021integral to membrane ----
    GO:0030424axon IEA--

    GRM3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GR: Glutamate receptors
    GRM: GPCR / Class C : Glutamate receptors, metabotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: mGlu3 receptor 
    Metabotropic glutamate receptors

    5/7 InterPro protein domains (see all 7):
     IPR011500 GPCR_3_9-Cys_dom
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR017978 GPCR_3_C
     IPR001234 GPCR_3_mtglu_rcpt_3

    Graphical View of Domain Structure for InterPro Entry Q14832

    ProtoNet protein and cluster: Q14832

    4 Blocks protein domains:
    IPB000162 Metabotropic glutamate receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001234 Metabotropic glutamate receptor 3 signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
    Similarity: Belongs to the G-protein coupled receptor 3 family


    GRM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRM3_HUMAN, Q14832
    Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
    cyclase activity

         Genatlas biochemistry entry for GRM3:
    metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP
    cascade

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001641group II metabotropic glutamate receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS8840013
    GO:0005246calcium channel regulator activity IEA--
    GO:0008066glutamate receptor activity TAS8840013
         
    GRM3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grm3):
     behavior/neurological  normal 

    GRM3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grm3tm1Ddsc for GRM3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRM3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRM3 

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate GRM3 (see all 23):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4251 hsa-miR-4263 hsa-miR-30d hsa-miR-132 hsa-miR-373* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidGRM3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRM3 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: Glutamatergic Excitation0.33
    GPCRs, Class C Metabotropic glutamate, pheromone0.33
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4CREB Pathway
    CREB Pathway0.68
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GRM3
        Glutamic acid signaling

    2 R&D Systems Pathways for GRM3
        Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: GABAergic Inhibition

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRM3
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Signaling in Gap Junctions

    1 BioSystems Pathway for GRM3
        GPCRs, Class C Metabotropic glutamate, pheromone

    5/6        Reactome Pathways for GRM3 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    G alpha (i) signalling events


    3         Kegg Pathways  (Kegg details for GRM3):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse
    Cocaine addiction


    GRM3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for GRM3 (Q148323 ENSP000003553164) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SDCBPO005603, ENSP000002601304I2D: score=4 STRING: ENSP00000260130
    GRASPQ7Z6J23, ENSP000002936624I2D: score=2 STRING: ENSP00000293662
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007194negative regulation of adenylate cyclase activity TAS8840013
    GO:0007268synaptic transmission TAS8840013
    GO:0050804regulation of synaptic transmission IEA--

    GRM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for GRM3

    Compounds for GRM3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DCG IV Very potent, selective group II mGlu agonist. Also NMDA agonist [147782-19-2]
    LY 341495 Highly potent, selective group II antagonist [201943-63-7]
    (S)-MCPGNon-selective mGlu antagonist. Active isomer of Cat. No. 0336[150145-89-4]
    LY 379268Highly selective group II mGlu agonist[191471-52-0]
    LY 341495 disodium saltDisodium salt of LY 341495 (Cat. No. 1209)--

    1 DrugBank Compound for GRM3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Acamprosate3-(Acetylamino)propanesulphonic acid (see all 4)77337-76-9targetantagonist17139284 17016423

    10/15 IUPHAR Ligands for GRM3 (mGlu3 receptor) (see all 15)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]LY341495
    AntagonistAntagonist9.110530814
    LY341495
    AntagonistAntagonist8.910530814
    LY354740
    AgonistFull agonist8.910530814
    L-CCG-I
    AgonistFull agonist7.410530814
    L-glutamic acid
    AgonistFull agonist7.410530814
    DCG-IV
    AgonistFull agonist7.210530814
    Ro4491533
    Allosteric regulatorNegative6.622091727
    (2R,3R)-APDC
    AgonistFull agonist5.310530814
    compound 3 [PMID: 21105727]
    Allosteric regulatorPositive5.121105727
    compound 4 [PMID: 21105727]
    Allosteric regulatorPositive4.9821105727

    10/19 Novoseek inferred chemical compound relationships for GRM3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naag 90.2 27 19285517 (3), 9202308 (3), 10899918 (2), 15030392 (2) (see all 13)
    n-acetyl-aspartyl-glutamate 89.1 8 19487395 (2), 15030392 (1), 19403271 (1), 9375663 (1) (see all 7)
    glutamate 82.7 148 15310849 (4), 17179862 (3), 12786977 (3), 18541626 (3) (see all 72)
    mcpg 55.7 1 9284353 (1)
    phencyclidine 50.1 1 14684454 (1)
    quisqualate 47 1 9076745 (1)
    nmda 45.5 11 10899918 (1), 16127367 (1), 10515165 (1), 19403271 (1) (see all 8)
    n-acetylaspartate 44.8 2 16585454 (2)
    ganciclovir 36.8 2 15652990 (1), 9076745 (1)
    phosphoinositide 31 1 7931274 (1)

    1 PharmGKB related drug/compound annotation for GRM3 gene    About this table
    Drug/compound PharmGKB Annotation
    risperidoneCA  

    Search CenterWatch for drugs/clinical trials and news about GRM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for GRM3 gene: 
    NM_000840.2  

    Unigene Cluster for GRM3:

    Glutamate receptor, metabotropic 3
    Hs.590575  [show with all ESTs]
    Unigene Representative Sequence: BC041407
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361669(uc003uid.3 uc010lef.3 uc010leg.3 uc010leh.3)
    ENST00000454217 ENST00000439827 ENST00000421579 ENST00000441140 ENST00000546348
    ENST00000536043 ENST00000394720

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    Additional mRNA sequence: 

    AK291406.1 AK294178.1 AK294701.1 BC022496.1 BC041407.1 DQ315361.1 DQ315362.1 DQ315363.1 
    EU432123.1 X77748.1 

    6 DOTS entries:

    DT.91986433  DT.313360  DT.121071873  DT.121071864  DT.121071865  DT.121071845 

    24/45 AceView cDNA sequences (see all 45):

    BX952998 X77748 AW953443 BX103501 N66150 BM805620 BF433273 N98673 
    H41839 NM_000840 H50424 AI077401 BG700844 BX410048 BC022496 C13970 
    AL540215 BC041407 F01525 AW138901 T08384 C13968 BI753076 T16733 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GRM3    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
    SP1:                          -     -                                                                     
    SP2:                          -     -           -     -     -     -     -                                 
    SP3:                          -     -     -                                                               
    SP4:                                -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for GRM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRM3 expression in normal human tissues (normalized intensities)      GRM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAGTCTAC
    GRM3 Expression
    About this image


    GRM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             Caudate nucleus   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See GRM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRM3

    SOURCE GeneReport for Unigene cluster: Hs.590575
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRM3: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRM3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grm31 , 5 glutamate receptor, metabotropic 31, 5 89.65(n)1
    96.7(a)1
      5 (3.69 cM)5
    1080691  NM_181850.21  NP_862898.11 
     94852365 
    chicken
    (Gallus gallus)
    Aves GRM31 glutamate receptor, metabotropic 3 79.98(n)
    91.01(a)
      418644  XM_416842.3  XP_416842.3 
    lizard
    (Anolis carolinensis)
    Reptilia GRM36
    Uncharacterized protein
    87(a)
    1 ↔ 1
    5(89672326-89736429)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5652561 similar to Metabotropic glutamate receptor 3 precursor more 71.35(n)
    78.57(a)
      565256  NM_001128343.1  NP_001121815.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glu-RA3
    mGluRA1
    metabotropic glutamate receptor
    signaling pathway more3
    metabotropic glutamate receptor1
    49(a)
    (best of 2)3
    54.04(n)1
    52.83(a)1
      438381  NM_079900.31  NP_524639.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mgl-11 , 3 metatrophic glutamate receptor3
    Protein MGL-11
    41(a)3
    50.54(n)1
    45.11(a)1
      X(10003865-10009638)3
    1917071  NM_001129721.11  NP_001123193.11 


    ENSEMBL Gene Tree for GRM3 (if available)
    TreeFam Gene Tree for GRM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRM3 gene
    GRM72  GRM42  TAS1R22  GRM82  TAS1R32  GRM22  TAS1R12  GRM62  
    GRM52  GRM12  GPRC6A2  
    11 SIMAP similar genes for GRM3 using alignment to 9 protein entries:     GRM3_HUMAN (see all proteins):
    GRM2    GRM8    GRM7    DKFZp686H1993    GRM5    GRM4
    GRM6    GRM1    TAS1R1    CASR    GPCR

    GRM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4097 SNPs in GRM3 are shown (see all 4097)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831316931,2
    --86271329(+) CTTAAG/TTGACA 1 -- us2k10--------
    rs795949151,2
    C,F--86271331(+) TAATTG/TACATG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1482103131,2
    --86271364(+) TTAGAA/CCTATC 1 -- us2k10--------
    rs1169828061,2
    F--86271365(+) TAGACC/TTATCC 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs746759581,2
    C,F--86271384(+) TTTTAA/CAAGTA 1 -- us2k11Minor allele frequency- C:0.05NA 120
    rs2003831171,2
    C--86271398(+) CGAAA-/ACAC  
            
    ACACA
    1 -- us2k10--------
    rs581555641,2
    C--86271438(+) CACAC-/ACA   
      C
    /CACC
    CAACA
    1 -- us2k10--------
    rs566998491,2
    C,F--86271561(+) TATTAT/CATAAA 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs2746161,2
    C,F,A,H--86271603(+) ATGCTG/TCTTAC 1 -- us2k112Minor allele frequency- T:0.20EA NS NA WA CSA 537
    rs1412000671,2
    --86271687(+) GACATA/GTAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRM3 (86273230 - 86494200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GRM3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667611CNV Deletion23128226
    esv2504097CNV Deletion19546169
    esv269784CNV Insertion20981092
    esv271910CNV Insertion20981092
    esv273882CNV Insertion20981092
    nsv824201CNV Loss20364138
    esv7104CNV Gain19470904
    nsv831053CNV Gain17160897
    nsv888633CNV Gain21882294


    Human Gene Mutation Database (HGMD): GRM3
    4 SABiosciences Cancer Mutation PCR Assays for GRM3:
    Cosmic IdAA Change
    94407p.S610L
    141841p.R352W
    96828p.R352Q
    110558p.G848E
    SeqTarget long-range PCR primers for resequencing GRM3
    DNA2.0 Custom Variant and Variant Library Synthesis for GRM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601115    OMIM disorders: --

    20/23 diseases for GRM3 (see all 23):    About MalaCards
    hyperaldosteronism    ganglioglioma    status epilepticus    bipolar i disorder
    bipolar disorder    schizophrenia    mood disorder    temporal lobe epilepsy
    alcohol dependence    pertussis    lateral sclerosis    amyotrophic lateral sclerosis
    alcoholism    huntington's disease    adenoma    neuroblastoma
    hypoxia    alzheimer's disease    melanoma    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for GRM3:
    Schizophrenia

    GRM3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for GRM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 65.7 63 18256595 (5), 15913960 (4), 19403271 (4), 15310849 (4) (see all 23)
    bipolar disorder 37 2 11840505 (2)
    glioma 17.1 3 12786977 (2), 16053698 (1)
    epilepsy 12.6 1 9459451 (1)
    genetic susceptibility 3.27 1 11840505 (1)

    Genetic Association Database (GAD): GRM3
    Human Genome Epidemiology (HuGE) Navigator: GRM3 (32 documents)

    Export disorders for GRM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRM3 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with GRM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analysis of Group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. (PubMed id 19386277)1, 4, 9 Tsunoka T....Iwata N. (2009)
    2. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. (PubMed id 12782962)1, 4, 9 Fujii Y....Fukumaki Y. (2003)
    3. Molecular characterization and localization of human metabotropic glutamate receptor type 3. (PubMed id 8840013)1, 2, 9 Makoff A.... Emson P. (1996)
    4. Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. (PubMed id 15913960)1, 4, 9 Bishop J.R....Miller D. (2005)
    5. Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex. (PubMed id 16585454)1, 4, 9 Marenco S....Weinberger D.R. (2006)
    6. No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population. (PubMed id 16904291)1, 4, 9 Tochigi M....Sasaki T. (2006)
    7. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. (PubMed id 15567072)1, 4, 9 Chen Q....He L. (2005)
    8. Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. (PubMed id 11840505)1, 4, 9 Marti S.B....Nothen M. (2002)
    9. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PubMed id 8824806)1, 3, 9 Scherer S.W....Tsui L.C. (1996)
    10. DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study. (PubMed id 18197082)1, 4, 9 Schwab S.G....Wildenauer D.B. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2913 HGNC: 4595 AceView: GRM3 Ensembl:ENSG00000198822 euGenes: HUgn2913
    ECgene: GRM3 Kegg: 2913 H-InvDB: GRM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRM3 gene:
    Search GeneIP for patents involving GRM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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