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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRM3 Gene

protein-coding   GIFtS: 68
GCID: GC07P086274

glutamate receptor, metabotropic 3
 Explore 26 diseases affiliated with
GRM3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GRM3    

Aliases
for GRM3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutamate Receptor, Metabotropic 31 2     GLUR32
GPRC1C1 2 3     Glutamate Metabotropic Receptor 32
MGLUR31 2 3     Metabotropic Glutamate Receptor 32
MGlu31     MGluR31

External Ids:    HGNC: 45951   Entrez Gene: 29132   Ensembl: ENSG000001988227   OMIM: 6011155   UniProtKB: Q148323   

Export aliases for GRM3 gene to outside databases

Previous GC identifers: GC07P084809 GC07P085871 GC07P085886 GC07P085885 GC07P085917 GC07P086111 GC07P080884


Summaries
for GRM3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GRM3:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function
and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G
protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal
transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been
shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.
Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist
selectivities. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
cyclase activity

summary for GRM3:
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided
into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o which inhibits adenylyl
cyclase, decreasing the formation of cAMP. mGlu group II receptors are involved in presynaptic inhibition
and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and
mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

Gene Wiki entry for GRM3 (Metabotropic glutamate receptor 3)


Genomic Views
for GRM3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRM3 gene promoter:
         CREB   Sox5   SRY   deltaCREB   HSF1 (long)   IRF-1   LCR-F1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GRM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1-q21.2   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.1-q21.2

GRM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086274:  view genomic region     (about GC identifiers)

Start:
 86,273,230 bp from pter      End:
 86,494,200 bp from pter
Size:
 220,971 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 85,604,962-85,825,938     

Proteins
for GRM3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 3 precursor  
Size: 879 amino acids; 98879 Da
Subunit: Interacts with GRASP (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAD15616.1; Type=Erroneous initiation; Sequence=CAA54796.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for GRM3:
1S8M (3D)        3SM9 (3D)    
Secondary accessions: Q75MV4 Q75N17 Q86YG6 Q8TBH9

Explore the universe of human proteins at neXtProt for GRM3: NX_Q14832

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14832

    • GRM3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000831.2  
    ENSEMBL proteins: 
     ENSP00000355316   ENSP00000405427   ENSP00000398767   ENSP00000390037   ENSP00000407490  
     ENSP00000444064   ENSP00000441407   ENSP00000378209  
    Reactome Protein details: Q14832
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: GRM3
    OriGene Custom Protein Services for GRM3 
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    Novus Biologicals GRM3 Proteins
    Novus Biologicals GRM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for GRM3

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8840013
    GO:0014069postsynaptic density IEA--
    GO:0016021integral to membrane ----
    GO:0030424axon IEA--


    GRM3 for ontologies           About GeneDecksing



    GRM3 Antibody Products: 
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    ThermoFisher Antibodies for GRM3

    Assay Products for GRM3: 
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    Uscn ELISAs and CLIAs for GRM3

    Protein Domains /
    Families
    for GRM3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GRM3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011500 GPCR_3_9-Cys_dom
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR017978 GPCR_3_C
     IPR001234 GPCR_3_mtglu_rcpt_3

    Graphical View of Domain Structure for InterPro Entry Q14832

    ProtoNet protein and cluster: Q14832

    4 Blocks protein families:
    IPB000162 Metabotropic glutamate receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001234 Metabotropic glutamate receptor 3 signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
    Similarity: Belongs to the G-protein coupled receptor 3 family


    Function
    for GRM3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
    Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate
    cyclase activity

         Genatlas biochemistry entry for GRM3:
    metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP
    cascade

    miRNA
    Products:            		 OriGene 3'-UTR Clone: GRM3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRM3
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate GRM3 (see all 23):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4251 hsa-miR-4263 hsa-miR-30d hsa-miR-132 hsa-miR-373* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: GRM3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRM3 (see all 7)
    OriGene shRNA RFP: GRM3
    OriGene siRNA: GRM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRM3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for GRM3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRM3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRM3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: GRM3 (NM_000840)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM3 

    Cell Line
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    Search LifeMap BioReagents cell lines for GRM3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001641group II metabotropic glutamate receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS8840013
    GO:0005246calcium channel regulator activity IEA--
    GO:0008066glutamate receptor activity TAS8840013


    GRM3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Grm3tm1Ddsc for GRM3
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Grm3):
     behavior/neurological  normal 

    GRM3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GRM3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class C/3 (Metabotropic glutamate/pheromone receptors)
    		Class C/3 (Metabotropic glutamate/pheromone receptors)1.00
    		Synaptic Neurotransmission: Glutamatergic Excitation0.33
    		GPCRs, Class C Metabotropic glutamate, pheromone0.58
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    3Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    4Glutamic acid signaling
    		Glutamic acid signaling1.00
    5Signaling in Gap Junctions
    		Signaling in Gap Junctions1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for GRM3
        Glutamic acid signaling

    2 R&D Systems Pathways for GRM3
        Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: GABAergic Inhibition

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRM3
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Signaling in Gap Junctions

    1 BioSystems Pathway for GRM3 
        GPCRs, Class C Metabotropic glutamate, pheromone

    4        Reactome Pathways for GRM3
        Signal Transduction
    Class C/3 (Metabotropic glutamate/pheromone receptors)
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for GRM3):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse


    GRM3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for GRM3 (Q148323 ENSP000003553164) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SDCBPO005603, ENSP000002601304I2D: score=4 STRING: ENSP00000260130
    GRASPQ7Z6J23, ENSP000002936624I2D: score=2 STRING: ENSP00000293662
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007194negative regulation of adenylate cyclase activity TAS8840013
    GO:0007268synaptic transmission TAS8840013
    GO:0050804regulation of synaptic transmission IEA--


    GRM3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GRM3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for GRM3

    Compounds for GRM3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 354740Potent and highly selective group II mGlu agonist[176199-48-7]
    DCG IV Very potent, selective group II mGlu agonist. Also NMDA agonist [147782-19-2]
    (S)-MCPGNon-selective mGlu antagonist. Active isomer of Cat. No. 0336[150145-89-4]
    LY 341495 Highly potent, selective group II antagonist [201943-63-7]
    LY 379268Highly selective group II mGlu agonist[191471-52-0]

    1 DrugBank Compound for GRM3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Acamprosate3-(Acetylamino)propanesulphonic acid (see all 3)77337-76-9targetantagonist17139284 17016423

    10/19 Novoseek chemical compound relationships for GRM3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naag 90.2 27 19285517 (3), 9202308 (3), 10899918 (2), 15030392 (2) (see all 13)
    n-acetyl-aspartyl-glutamate 89.1 8 19487395 (2), 15030392 (1), 19403271 (1), 9375663 (1) (see all 7)
    glutamate 82.7 148 15310849 (4), 17179862 (3), 12786977 (3), 18541626 (3) (see all 72)
    mcpg 55.7 1 9284353 (1)
    phencyclidine 50.1 1 14684454 (1)
    quisqualate 47 1 9076745 (1)
    nmda 45.5 11 10899918 (1), 16127367 (1), 10515165 (1), 19403271 (1) (see all 8)
    n-acetylaspartate 44.8 2 16585454 (2)
    ganciclovir 36.8 2 15652990 (1), 9076745 (1)
    phosphoinositide 31 1 7931274 (1)

    1 PharmGKB related drug/compound annotation for GRM3 gene
    Drug/compound PharmGKB Annotation
    risperidoneCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about GRM3 

    Transcripts
    for GRM3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GRM3 gene: 
    NM_000840.2  

    Unigene Cluster for GRM3:

    Glutamate receptor, metabotropic 3
    Hs.590575  [show with all ESTs]
    Unigene Representative Sequence: BC041407
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361669(uc003uid.3 uc010lef.3 uc010leg.3 uc010leh.3)
    ENST00000454217 ENST00000439827 ENST00000421579 ENST00000441140 ENST00000546348
    ENST00000536043 ENST00000394720

    miRNA
    Products:             		 OriGene 3'-UTR Clone: GRM3
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRM3
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate GRM3 (see all 23):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4251 hsa-miR-4263 hsa-miR-30d hsa-miR-132 hsa-miR-373* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: GRM3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRM3 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK291406.1 AK294178.1 AK294701.1 BC022496.1 BC041407.1 DQ315361.1 DQ315362.1 DQ315363.1 
    EU432123.1 X77748.1 

    6 DOTS entries:

    DT.91986433  DT.313360  DT.121071873  DT.121071864  DT.121071865  DT.121071845 

    24/45 AceView cDNA sequences (see all 45):

    BX103501 X77748 BX952998 H50424 H41839 AW953443 BG700844 BF433273 
    BM805620 NM_000840 N98673 AI077401 N66150 T08384 BI753076 AW138901 
    T16733 BC022496 C13970 C13968 AL540215 F01525 BX410048 BC041407 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GRM3    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
    SP1:                          -     -                                                                     
    SP2:                          -     -           -     -     -     -     -                                 
    SP3:                          -     -     -                                                               
    SP4:                                -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for GRM3

    Expression
    for GRM3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAGTCTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GRM3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See GRM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRM3

    SOURCE GeneReport for Unigene cluster: Hs.590575
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRM3: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    Orthologs
    for GRM3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for GRM3 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves GRM31 glutamate receptor, metabotropic 3 79.98(n)
    91.01(a)    		   418644  XM_416842.3  XP_416842.3 
    lizard
    (Anolis carolinensis)    		 Reptilia GRM36
    		 --
    		 88(a)
    		 1 ↔ 1
    		 5(89672470-89734808)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5652561 similar to Metabotropic glutamate receptor 3 precursor more 71.35(n)
    78.57(a)    		   565256  NM_001128343.1  NP_001121815.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Glu-RA3
    mGluRA1    		 metabotropic glutamate receptor signaling
    pathway more3
    metabotropic glutamate receptor1    		 49(a)
    (best of 2)3
    54.04(n)1
    52.83(a)1    		   438381  NM_079900.31  NP_524639.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea mgl-11 , 3 metatrophic glutamate receptor3
    Protein MGL-11    		 41(a)3
    50.54(n)1
    45.11(a)1    		   X(10003865-10009638)3
    1917071  NM_001129721.11  NP_001123193.11 


    ENSEMBL Gene Tree for GRM3 (if available)
    TreeFam Gene Tree for GRM3 (if available) 

    Paralogs
    for GRM3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRM3 gene
    GRM72  GRM42  GRM62  GRM82  GRM22  GRM52  GRM12  
    11 SIMAP similar genes for GRM3 using alignment to 9 protein entries:     GRM3_HUMAN (see all proteins):
    GRM2    GRM8    GRM7    DKFZp686H1993    GRM5    GRM6
    GRM4    GRM1    TAS1R1    CASR    GPCR

    GRM3 for paralogs           About GeneDecksing



    Genomic Variants
    for GRM3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3513 NCBI SNPs in GRM3 are shown (see all 3513)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1831316931,2
    		--86271329(+) CTTAAG/TTGACA 1 -- us2k10--------
    rs795949151,2
    		F,--86271331(+) TAATTG/TACATG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1482103131,2
    		--86271364(+) TTAGAA/CCTATC 1 -- us2k10--------
    rs1169828061,2
    		--86271365(+) TAGACC/TTATCC 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs746759581,2
    		C,F,--86271384(+) TTTTAA/CAAGTA 1 -- us2k11Minor allele frequency- C:0.05NA 120
    rs1474290161,2
    		C,--86271398(+) CGAAA-/ACACACACA
    CACACACACAC    ACACA     		1 -- us2k10--------
    rs673109671,2
    		C--86271402(-) TGTTG-/GTGTGTGTG
    TGTGTGTGTGT    GTGTG     		1 -- us2k11Minor allele frequency- GTGTGTGTGTGTGTGTGTGT:0.00NA 2
    rs566998491,2
    		C,--86271561(+) TATTAT/CATAAA 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs2746161,2
    		C,F,A,H,--86271603(+) ATGCTG/TCTTAC 1 -- us2k112Minor allele frequency- T:0.20EA NS NA WA CSA 537
    rs1412000671,2
    		--86271687(+) GACATA/GTAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRM3 (86273230 - 86494200 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for GRM3
         1 CNV: 100013
         1 Indel: 60667
    Human Gene Mutation Database (HGMD): GRM3

    4 SABiosciences Cancer Mutation PCR Assays for GRM3:
    Cosmic IdAA Change
    94407p.S610L
    141841p.R352W
    96828p.R352Q
    110558p.G848E
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRM3
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    Disorders / Diseases
    for GRM3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GRM3 for disorders           About GeneDecksing

    OMIM gene information: 601115    OMIM disorders: --

    20/26 diseases for GRM3 (see all 26):    About MalaCards
    temporal lobe epilepsy    status epilepticus    bipolar affective disorder    amyotrophic lateral sclerosis
    bipolar i disorder    lateral sclerosis    bipolar disorder    alcohol dependence
    hyperaldosteronism    mood disorder    ganglioglioma    huntington's disease
    aldosteronism    pertussis    alcoholism    alzheimer's disease
    schizophrenia    pharyngitis    prostate cancer    adenoma

    1 disease from the University of Copenhagen DISEASES database for GRM3:
    Schizophrenia

    5 Novoseek disease relationships for GRM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 65.7 63 18256595 (5), 15913960 (4), 19403271 (4), 15310849 (4) (see all 23)
    bipolar disorder 37 2 11840505 (2)
    glioma 17.1 3 12786977 (2), 16053698 (1)
    epilepsy 12.6 1 9459451 (1)
    genetic susceptibility 3.27 1 11840505 (1)

    Genetic Association Database (GAD): GRM3
    Human Genome Epidemiology (HuGE) Navigator: GRM3 (32 documents)

    Export disorders for GRM3 gene to outside databases

    Publications
    for GRM3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRM3 gene, integrated from 9 sources (see all 144):
    (articles sorted by number of sources associating them with GRM3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. (PubMed id 12782962)1, 4, 9 Fujii Y....Fukumaki Y. (2003)
    2. Molecular characterization and localization of human metabotropic glutamate receptor type 3. (PubMed id 8840013)1, 2, 9 Makoff A.... Emson P. (1996)
    3. Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. (PubMed id 15913960)1, 4, 9 Bishop J.R....Miller D. (2005)
    4. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. (PubMed id 15567072)1, 4, 9 Chen Q....He L. (2005)
    5. Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. (PubMed id 11840505)1, 4, 9 Marti S.B....Nothen M. (2002)
    6. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PubMed id 8824806)1, 3, 9 Scherer S.W....Tsui L.C. (1996)
    7. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PubMed id 16380905)1, 4, 9 Fallin M.D....Pulver A.E. (2005)
    8. No evidence for association between polymorphisms in GRM3 and schizophrenia. (PubMed id 15892884)1, 4 Norton N....Owen M.J. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)

    External Searches for GRM3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing GRM3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2913 HGNC: 4595 AceView: GRM3 Ensembl:ENSG00000198822 euGenes: HUgn2913
    ECgene: GRM3 Kegg: 2913 H-InvDB: GRM3

    Other Databases showing GRM3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing GRM3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRM3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for GRM3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GRM3 gene:
    Search GeneIP for patents involving GRM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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