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Aliases for GRM3 Gene

Aliases for GRM3 Gene

  • Glutamate Metabotropic Receptor 3 2 3
  • Glutamate Receptor, Metabotropic 3 2 3 5
  • GPRC1C 3 4
  • MGLUR3 3 4
  • GLUR3 3
  • MGlu3 3

External Ids for GRM3 Gene

Previous GeneCards Identifiers for GRM3 Gene

  • GC07P084809
  • GC07P085871
  • GC07P085886
  • GC07P085885
  • GC07P085917
  • GC07P086111
  • GC07P086274
  • GC07P080884

Summaries for GRM3 Gene

Entrez Gene Summary for GRM3 Gene

  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRM3 Gene

GRM3 (Glutamate Metabotropic Receptor 3) is a Protein Coding gene. Diseases associated with GRM3 include Schizophrenia and Status Epilepticus. Among its related pathways are Taste transduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM1.

UniProtKB/Swiss-Prot for GRM3 Gene

  • G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Tocris Summary for GRM3 Gene

  • Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3.

Gene Wiki entry for GRM3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRM3 Gene

Genomics for GRM3 Gene

Regulatory Elements for GRM3 Gene

Enhancers for GRM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRM3 Gene

86,643,914 bp from pter
86,864,884 bp from pter
220,971 bases
Plus strand

Genomic View for GRM3 Gene

Genes around GRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRM3 Gene

Proteins for GRM3 Gene

  • Protein details for GRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metabotropic glutamate receptor 3
    Protein Accession:
    Secondary Accessions:
    • Q2PNZ6
    • Q75MV4
    • Q75N17
    • Q86YG6
    • Q8TBH9

    Protein attributes for GRM3 Gene

    879 amino acids
    Molecular mass:
    98879 Da
    Quaternary structure:
    • Interacts with GRASP.
    • Sequence=AAD15616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRM3 Gene

    Alternative splice isoforms for GRM3 Gene


neXtProt entry for GRM3 Gene

Proteomics data for GRM3 Gene at MOPED

Post-translational modifications for GRM3 Gene

  • Glycosylation at Asn 209, Asn 292, Asn 414, and Asn 439
  • Modification sites at PhosphoSitePlus

Other Protein References for GRM3 Gene

No data available for DME Specific Peptides for GRM3 Gene

Domains & Families for GRM3 Gene

Gene Families for GRM3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GRM3: view

Function for GRM3 Gene

Molecular function for GRM3 Gene

GENATLAS Biochemistry:
metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP cascade
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
genes like me logo Genes that share phenotypes with GRM3: view

Animal Models for GRM3 Gene

MGI Knock Outs for GRM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRM3

miRNA for GRM3 Gene

miRTarBase miRNAs that target GRM3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRM3 Gene

Localization for GRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRM3 Gene COMPARTMENTS Subcellular localization image for GRM3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8840013
GO:0014069 postsynaptic density IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with GRM3: view

Pathways & Interactions for GRM3 Gene

genes like me logo Genes that share pathways with GRM3: view

Gene Ontology (GO) - Biological Process for GRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0051966 regulation of synaptic transmission, glutamatergic IBA --
genes like me logo Genes that share ontologies with GRM3: view

No data available for SIGNOR curated interactions for GRM3 Gene

Drugs & Compounds for GRM3 Gene

(30) Drugs for GRM3 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heroin Approved, Illicit Pharma 109
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 477
LY2140023 Investigational Pharma Target 0
NAAG Pharma Full agonist, Agonist 0
(+)-MCPG Pharma Antagonist 0

(14) Additional Compounds for GRM3 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Xanthurenic acid
  • 4,8-Dihydroxy-2-quinolinecarboxylate
  • 4,8-Dihydroxy-2-quinolinecarboxylic acid
  • 4,8-Dihydroxy-Quinaldate
  • 4,8-Dihydroxy-Quinaldic acid
  • 4,8-Dihydroxyquinaldate

(5) Tocris Compounds for GRM3 Gene

Compound Action Cas Number
(+-)-trans-ACPD Group I/group II mGlu agonist 67684-64-4
(1S,3R)-ACPD Group I/group II mGlu agonist 111900-32-4
(S)-4-Carboxy-3-hydroxyphenylglycine Group I antagonist/group II agonist 85148-82-9
cis-ACPD Potent NMDA agonist. Also group II mGluR agonist 477331-06-9
Xanthurenic acid Selectively activates group II mGlu receptors 59-00-7
genes like me logo Genes that share compounds with GRM3: view

Transcripts for GRM3 Gene

Unigene Clusters for GRM3 Gene

Glutamate receptor, metabotropic 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRM3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: - - - - - - -
SP3: - - -
SP4: -

Relevant External Links for GRM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRM3 Gene

mRNA expression in normal human tissues for GRM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRM3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.7), Brain - Caudate (basal ganglia) (x6.6), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Spinal cord (cervical c-1) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.1), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GRM3 Gene

This gene is overexpressed in NK cells (36.3), Fetal Brain (13.8), Frontal cortex (12.4), and Pancreatic juice (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRM3 Gene

SOURCE GeneReport for Unigene cluster for GRM3 Gene Hs.590575

mRNA Expression by UniProt/SwissProt for GRM3 Gene

Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
genes like me logo Genes that share expression patterns with GRM3: view

Protein tissue co-expression partners for GRM3 Gene

- Elite partner

Primer Products

Orthologs for GRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRM3 35
  • 92.07 (n)
  • 97.27 (a)
GRM3 36
  • 97 (a)
(Canis familiaris)
Mammalia GRM3 35
  • 92.03 (n)
  • 96.33 (a)
GRM3 36
  • 91 (a)
(Mus musculus)
Mammalia Grm3 35
  • 89.65 (n)
  • 96.7 (a)
Grm3 16
Grm3 36
  • 97 (a)
(Pan troglodytes)
Mammalia GRM3 35
  • 99.73 (n)
  • 99.66 (a)
GRM3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Grm3 35
  • 89.95 (n)
  • 96.59 (a)
(Monodelphis domestica)
Mammalia GRM3 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia GRM3 36
  • 87 (a)
(Gallus gallus)
Aves GRM3 35
  • 79.98 (n)
  • 91.01 (a)
GRM3 36
  • 90 (a)
(Anolis carolinensis)
Reptilia GRM3 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grm3 35
  • 74.07 (n)
  • 86.21 (a)
(Danio rerio)
Actinopterygii grm3 35
  • 71.31 (n)
  • 78.57 (a)
grm3 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30361 37
  • 39 (a)
Glu-RA 37
  • 49 (a)
mGluRA 35
  • 54.48 (n)
  • 53.15 (a)
mGluRA 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea mgl-1 37
  • 41 (a)
mgl-1 35
  • 50.54 (n)
  • 45.11 (a)
mgl-1 36
  • 36 (a)
Species with no ortholog for GRM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRM3 Gene

Gene Tree for GRM3 (if available)
Gene Tree for GRM3 (if available)

Paralogs for GRM3 Gene

Paralogs for GRM3 Gene

genes like me logo Genes that share paralogs with GRM3: view

Variants for GRM3 Gene

Sequence variations from dbSNP and Humsavar for GRM3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17161026 - 86,838,938(-) TTCCA(C/T)CTACA intron-variant, reference, missense
rs802420 -- 86,661,861(+) ACTAT(C/T)TATTA intron-variant
rs802421 -- 86,662,130(+) TTCTT(A/T)TTTTG intron-variant
rs802422 -- 86,664,377(+) TTGAT(A/G)TGTTT intron-variant
rs802423 -- 86,664,483(+) TAGGG(A/G)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRM3 Gene

Variant ID Type Subtype PubMed ID
nsv888633 CNV Gain 21882294
nsv831053 CNV Gain 17160897
esv7104 CNV Gain 19470904
nsv824201 CNV Loss 20364138
esv269784 CNV Insertion 20981092
esv273882 CNV Insertion 20981092
esv2667611 CNV Deletion 23128226
esv271910 CNV Insertion 20981092
esv2504097 CNV Deletion 19546169

Variation tolerance for GRM3 Gene

Residual Variation Intolerance Score: 4.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRM3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRM3 Gene

Disorders for GRM3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GRM3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • schizophrenia 12
status epilepticus
  • gcse
disease of mental health
  • mental disorders
- elite association - COSMIC cancer census association via MalaCards
Search GRM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRM3 Gene

Publications for GRM3 Gene

  1. Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. (PMID: 19386277) Tsunoka T. … Iwata N. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2009) 3 23 48 67
  2. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PMID: 8824806) Scherer S.W. … Tsui L.C. (Genomics 1996) 2 3 23
  3. Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia. (PMID: 19403271) Ghose S. … Tamminga C. (Schizophr. Res. 2009) 3 23
  4. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. (PMID: 19439994) JAPnsson E.G. … Terenius L. (Neuropsychobiology 2009) 3 23
  5. DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study. (PMID: 18197082) Schwab S.G. … Wildenauer D.B. (Psychiatr. Genet. 2008) 3 23

Products for GRM3 Gene

Sources for GRM3 Gene