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GRM3 Gene

protein-coding   GIFtS: 69
GCID: GC07P086274

Glutamate Receptor, Metabotropic 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Metabotropic 31 2     Glutamate Metabotropic Receptor 32
GPRC1C2 3     mGlu32
MGLUR32 3     Metabotropic Glutamate Receptor 32
GLUR32     mGluR33

External Ids:    HGNC: 45951   Entrez Gene: 29132   Ensembl: ENSG000001988227   OMIM: 6011155   UniProtKB: Q148323   

Export aliases for GRM3 gene to outside databases

Previous GC identifers: GC07P084809 GC07P085871 GC07P085886 GC07P085885 GC07P085917 GC07P086111 GC07P080884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRM3 Gene:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic
and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain
function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a
family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology,
putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes
GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but
differ in their agonist selectivities. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRM3 Gene:
GRM3 (glutamate receptor, metabotropic 3) is a protein-coding gene. Diseases associated with GRM3 include hyperaldosteronism, and ganglioglioma. GO annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
effectors. Signaling inhibits adenylate cyclase activity

summary for GRM3 Gene:
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided
into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o which inhibits adenylyl
cyclase, decreasing the formation of cAMP. mGlu group II receptors are involved in presynaptic inhibition
and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and
mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.

Gene Wiki entry for GRM3 (Metabotropic glutamate receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRM3 gene promoter:
         CREB   Sox5   SRY   deltaCREB   HSF1 (long)   IRF-1   LCR-F1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): GRM3 promoter sequence
   Search Chromatin IP Primers for GRM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.1-q21.2   Ensembl cytogenetic band:  7q21.11   HGNC cytogenetic band: 7q21.1-q21.2

GRM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P086274:  view genomic region     (about GC identifiers)

Start:
86,273,230 bp from pter      End:
86,494,200 bp from pter
Size:
220,971 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 85,604,962-85,825,938     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 3 precursor  
Size: 879 amino acids; 98879 Da
Subunit: Interacts with GRASP (By similarity)
Sequence caution: Sequence=AAD15616.1; Type=Erroneous initiation; Sequence=ABC47402.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAA54796.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for GRM3:
1S8M (3D)        3SM9 (3D)    
Secondary accessions: Q2PNZ6 Q75MV4 Q75N17 Q86YG6 Q8TBH9
Alternative splicing: 2 isoforms:  Q14832-1   Q14832-2   (Appears to be membrane-associated, despite the absence of the seven-transmembrane domain)

Explore the universe of human proteins at neXtProt for GRM3: NX_Q14832

Explore proteomics data for GRM3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn209, Asn292, Asn414, Asn439
  • Modification sites at PhosphoSitePlus

  • See GRM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000831.2  
    ENSEMBL proteins: 
     ENSP00000355316   ENSP00000405427   ENSP00000398767   ENSP00000390037   ENSP00000407490  
     ENSP00000444064   ENSP00000441407   ENSP00000378209  
    Reactome Protein details: Q14832

    GRM3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRM3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRM3
    GenScript Custom Purified and Recombinant Proteins Services for GRM3
    Novus Biologicals GRM3 Proteins
    Novus Biologicals GRM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRM3

    GRM3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for GRM3 (mGluR3)
    OriGene Antibodies for GRM3
    OriGene Custom Antibody Services for GRM3
    Novus Biologicals GRM3 Antibodies
    Abcam antibodies for GRM3
    Cloud-Clone Corp. Antibodies for GRM3
    ThermoFisher Antibodies for GRM3
    LSBio Antibodies in human, mouse, rat for GRM3

    GRM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for GRM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRM3
    Cloud-Clone Corp. CLIAs for GRM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GR: Glutamate receptors
    GRM: GPCR / Class C : Glutamate receptors, metabotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: mGlu3 receptor
    Metabotropic glutamate receptors

    Selected InterPro protein domains (see all 8):
     IPR011500 GPCR_3_9-Cys_dom
     IPR028082 Peripla_BP_I
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR017978 GPCR_3_C

    Graphical View of Domain Structure for InterPro Entry Q14832

    ProtoNet protein and cluster: Q14832

    4 Blocks protein domains:
    IPB000162 Metabotropic glutamate receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001234 Metabotropic glutamate receptor 3 signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
    Similarity: Belongs to the G-protein coupled receptor 3 family


    GRM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRM3_HUMAN, Q14832
    Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
    signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
    effectors. Signaling inhibits adenylate cyclase activity

         Genatlas biochemistry entry for GRM3:
    metabotropic glutamate receptor 3,group II,G protein coupled receptor superfamily,linked to the inhibition of cAMP
    cascade

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001641group II metabotropic glutamate receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS8840013
    GO:0005246calcium channel regulator activity IEA--
    GO:0008066glutamate receptor activity TAS8840013
         
    GRM3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grm3):
     behavior/neurological  normal 

    GRM3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grm3tm1Ddsc for GRM3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRM3

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRM3:
    hsa-mir-335-5p (MIRT018386)

    Block miRNA regulation of human, mouse, rat GRM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM3 (see all 23):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4251 hsa-miR-4263 hsa-miR-30d hsa-miR-132 hsa-miR-373* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidGRM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRM3
    Predesigned siRNA for gene silencing in human, mouse, rat GRM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRM3

    Clone
    Products:
         
    OriGene clones in human, mouse for GRM3 (see all 7)
    OriGene ORF clones in mouse, rat for GRM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRM3 (NM_000840)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRM3
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRM3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRM3_HUMAN, Q14832: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8840013
    GO:0014069postsynaptic density IEA--
    GO:0016021integral component of membrane ----
    GO:0030424axon IEA--

    GRM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRM3 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Glutamic acid signaling
    Glutamic acid signaling
    Synaptic Neurotransmission: Glutamatergic Excitation0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    CREB Pathway0.68
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for GRM3
        Synaptic Neurotransmission: Glutamatergic Excitation
    Synaptic Neurotransmission: GABAergic Inhibition

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRM3
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Signaling in Gap Junctions

    1 BioSystems Pathway for GRM3
        GPCRs, Class C Metabotropic glutamate, pheromone

    2 Reactome Pathways for GRM3
        Class C/3 (Metabotropic glutamate/pheromone receptors)
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for GRM3):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse
    Cocaine addiction


    GRM3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM3: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for GRM3 (Q148323 ENSP000003553164) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SDCBPO005603, ENSP000002601304I2D: score=4 STRING: ENSP00000260130
    GRASPQ7Z6J23, ENSP000002936624I2D: score=2 STRING: ENSP00000293662
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007194negative regulation of adenylate cyclase activity TAS8840013
    GO:0007268synaptic transmission TAS8840013
    GO:0050804regulation of synaptic transmission IEA--

    GRM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GRM3
      Browse compounds at ApexBio 

    Compounds for GRM3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DCG IV Very potent, selective group II mGlu agonist. Also NMDA agonist [147782-19-2]
    LY 341495 Highly potent, selective group II antagonist [201943-63-7]
    (S)-MCPGNon-selective mGlu antagonist. Active isomer of Cat. No. 0336[150145-89-4]
    LY 379268Highly selective group II mGlu agonist[191471-52-0]
    LY 341495 disodium saltDisodium salt of LY 341495 (Cat. No. 1209)--

    1 DrugBank Compound for GRM3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Acamprosate3-(Acetylamino)propanesulphonic acid (see all 4)77337-76-9targetantagonist17139284 17016423

    Selected IUPHAR Ligands for GRM3 (mGlu3 receptor) (see all 15)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]LY341495
    AntagonistAntagonist9.110530814
    LY341495
    AntagonistAntagonist8.910530814
    LY354740
    AgonistFull agonist8.910530814
    L-CCG-I
    AgonistFull agonist7.410530814
    L-glutamic acid
    AgonistFull agonist7.410530814
    DCG-IV
    AgonistFull agonist7.210530814
    Ro4491533
    Allosteric regulatorNegative6.622091727
    (2R,3R)-APDC
    AgonistFull agonist5.310530814
    compound 3 [PMID: 21105727]
    Allosteric regulatorPositive5.121105727
    compound 4 [PMID: 21105727]
    Allosteric regulatorPositive4.9821105727

    Selected Novoseek inferred chemical compound relationships for GRM3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    naag 90.2 27 19285517 (3), 9202308 (3), 10899918 (2), 15030392 (2) (see all 13)
    n-acetyl-aspartyl-glutamate 89.1 8 19487395 (2), 15030392 (1), 19403271 (1), 9375663 (1) (see all 7)
    glutamate 82.7 148 15310849 (4), 17179862 (3), 12786977 (3), 18541626 (3) (see all 72)
    mcpg 55.7 1 9284353 (1)
    phencyclidine 50.1 1 14684454 (1)
    quisqualate 47 1 9076745 (1)
    nmda 45.5 11 10899918 (1), 16127367 (1), 10515165 (1), 19403271 (1) (see all 8)
    n-acetylaspartate 44.8 2 16585454 (2)
    ganciclovir 36.8 2 15652990 (1), 9076745 (1)
    phosphoinositide 31 1 7931274 (1)

    1 PharmGKB related drug/compound annotation for GRM3 gene    About this table
    Drug/compound PharmGKB Annotation
    risperidoneCA  



    GRM3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRM3 gene: 
    NM_000840.2  

    Unigene Cluster for GRM3:

    Glutamate receptor, metabotropic 3
    Hs.590575  [show with all ESTs]
    Unigene Representative Sequence: BC041407
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361669(uc003uid.3 uc010lef.3 uc010leg.3 uc010leh.3)
    ENST00000454217 ENST00000439827 ENST00000421579 ENST00000441140 ENST00000546348
    ENST00000536043 ENST00000394720

    miRNA
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    Block miRNA regulation of human, mouse, rat GRM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM3 (see all 23):
    hsa-miR-30c hsa-miR-3607-3p hsa-miR-4251 hsa-miR-4263 hsa-miR-30d hsa-miR-132 hsa-miR-373* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidGRM3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GRM3
    Predesigned siRNA for gene silencing in human, mouse, rat GRM3
    Clone
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    OriGene clones in human, mouse for GRM3 (see all 7)
    OriGene ORF clones in mouse, rat for GRM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRM3 (NM_000840)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for GRM3
    OriGene qSTAR qPCR primer pairs in human, mouse for GRM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRM3
      QuantiTect SYBR Green Assays in human, mouse, rat GRM3
      QuantiFast Probe-based Assays in human, mouse, rat GRM3

    Additional mRNA sequence: 

    AK291406.1 AK294178.1 AK294701.1 BC022496.1 BC041407.1 DQ315361.1 DQ315362.1 DQ315363.1 
    EU432123.1 X77748.1 

    6 DOTS entries:

    DT.91986433  DT.313360  DT.121071873  DT.121071864  DT.121071865  DT.121071845 

    Selected AceView cDNA sequences (see all 45):

    BF433273 BX103501 N98673 BM805620 N66150 AI077401 H41839 BG700844 
    NM_000840 X77748 BX952998 AW953443 H50424 AW138901 BI753076 C13968 
    T16733 F01525 BC041407 C13970 BC022496 BX410048 T08384 AL540215 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GRM3    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
    SP1:                          -     -                                                                     
    SP2:                          -     -           -     -     -     -     -                                 
    SP3:                          -     -     -                                                               
    SP4:                                -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for GRM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRM3 expression in normal human tissues (normalized intensities)      GRM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAGTCTAC
    GRM3 Expression
    About this image


    GRM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
             Floor plate-like cells
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    GRM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRM3 Protein Expression

    Genevestigator expression for GRM3

    SOURCE GeneReport for Unigene cluster: Hs.590575

    UniProtKB/Swiss-Prot: GRM3_HUMAN, Q14832
    Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus,
    hippocampus, corpus callosum, caudate nucleus and amygdala

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM3: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRM3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grm31 , 5 glutamate receptor, metabotropic 31, 5 89.65(n)1
    96.7(a)1
      5 (3.69 cM)5
    1080691  NM_181850.21  NP_862898.11 
     94852365 
    chicken
    (Gallus gallus)
    Aves GRM31 glutamate receptor, metabotropic 3 79.98(n)
    91.01(a)
      418644  XM_416842.4  XP_416842.3 
    lizard
    (Anolis carolinensis)
    Reptilia GRM36
    glutamate receptor, metabotropic 3
    87(a)
    1 ↔ 1
    5(89672326-89736429)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grm31 glutamate receptor, metabotropic 3 74.07(n)
    86.21(a)
      100492610  XM_002935246.2  XP_002935292.2 
    zebrafish
    (Danio rerio)
    Actinopterygii grm31 glutamate receptor, metabotropic 3 71.31(n)
    78.57(a)
      565256  NM_001128343.1  NP_001121815.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glu-RA3
    mGluRA1
    metabotropic glutamate receptor
    signaling pathway more3
    metabotropic glutamate receptor1
    49(a)
    (best of 2)3
    54.48(n)1
    53.15(a)1
      438381  NM_001272147.11  NP_001259076.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mgl-11 , 3 metatrophic glutamate receptor3
    mgl-11
    41(a)3
    50.54(n)1
    45.11(a)1
      X(10003865-10009638)3
    1917071  NM_001129721.11  NP_001123193.11 


    ENSEMBL Gene Tree for GRM3 (if available)
    TreeFam Gene Tree for GRM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRM3 gene
    GRM72  GRM42  TAS1R22  GRM82  TAS1R32  GRM22  TAS1R12  GRM62  
    GRM52  GRM12  GPRC6A2  
    11 SIMAP similar genes for GRM3 using alignment to 7 protein entries:     GRM3_HUMAN (see all proteins):
    GRM2    GRM8    DKFZp686H1993    GRM7    GRM5    GRM6
    GRM4    GRM1    TAS1R1    CASR    GPCR

    GRM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRM3 (see all 4097)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831316931,2
    --86271329(+) CTTAAG/TTGACA 1 -- us2k10--------
    rs795949151,2
    C,F--86271331(+) TAATTG/TACATG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1482103131,2
    --86271364(+) TTAGAA/CCTATC 1 -- us2k10--------
    rs1169828061,2
    F--86271365(+) TAGACC/TTATCC 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs746759581,2
    C,F--86271384(+) TTTTAA/CAAGTA 1 -- us2k11Minor allele frequency- C:0.05NA 120
    rs2003831171,2
    C--86271398(+) CGAAA-/ACAC  
            
    ACACA
    1 -- us2k10--------
    rs581555641,2
    C--86271438(+) CACAC-/ACA   
      C
    /CACC
    CAACA
    1 -- us2k10--------
    rs566998491,2
    C,F--86271561(+) TATTAT/CATAAA 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs2746161,2
    C,F,A,H--86271603(+) ATGCTG/TCTTAC 1 -- us2k112Minor allele frequency- T:0.20EA NS NA WA CSA 537
    rs1412000671,2
    --86271687(+) GACATA/GTAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRM3 (86273230 - 86494200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for GRM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667611CNV Deletion23128226
    esv2504097CNV Deletion19546169
    esv269784CNV Insertion20981092
    esv271910CNV Insertion20981092
    esv273882CNV Insertion20981092
    nsv824201CNV Loss20364138
    esv7104CNV Gain19470904
    nsv831053CNV Gain17160897
    nsv888633CNV Gain21882294

    Human Gene Mutation Database (HGMD): GRM3
    4 Site Specific Mutation Identification with PCR Assays for GRM3:
    Cosmic IdAA Change
    94407p.S610L
    141841p.R352W
    96828p.R352Q
    110558p.G848E
    SeqTarget long-range PCR primers for resequencing GRM3
    DNA2.0 Custom Variant and Variant Library Synthesis for GRM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601115    OMIM disorders: --

    Selected diseases for GRM3 (see all 25):    About MalaCards
    hyperaldosteronism    ganglioglioma    status epilepticus    bipolar i disorder
    bipolar disorder    schizophrenia    temporal lobe epilepsy    mood disorder
    alcohol dependence    pertussis    lateral sclerosis    amyotrophic lateral sclerosis
    malignant glioma    huntington's disease    adenoma    neuroblastoma
    hypoxia    alzheimer's disease    prostatitis    melanoma

    1 disease from the University of Copenhagen DISEASES database for GRM3:
    Schizophrenia

    GRM3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for GRM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 65.7 63 18256595 (5), 15913960 (4), 19403271 (4), 15310849 (4) (see all 23)
    bipolar disorder 37 2 11840505 (2)
    glioma 17.1 3 12786977 (2), 16053698 (1)
    epilepsy 12.6 1 9459451 (1)
    genetic susceptibility 3.27 1 11840505 (1)

    Genetic Association Database (GAD): GRM3
    Human Genome Epidemiology (HuGE) Navigator: GRM3 (32 documents)

    Export disorders for GRM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRM3 gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with GRM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population. (PubMed id 19386277)1, 4, 9 Tsunoka T....Iwata N. (amp 2009)
    2. Alternative splicing of human metabotropic glutamate receptor 3. (PubMed id 16417579)1, 2, 9 Sartorius L.J.... Harrison P.J. (J. Neurochem. 2006)
    3. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. (PubMed id 12782962)1, 4, 9 Fujii Y....Fukumaki Y. (Psychiatr. Genet. 2003)
    4. Molecular characterization and localization of human metabotropic glutamate receptor type 3. (PubMed id 8840013)1, 2, 9 Makoff A.... Emson P. (Brain Res. Mol. Brain Res. 1996)
    5. Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment. (PubMed id 15913960)1, 4, 9 Bishop J.R....Miller D. (Schizophr. Res. 2005)
    6. Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex. (PubMed id 16585454)1, 4, 9 Marenco S....Weinberger D.R. (Am J Psychiatry 2006)
    7. No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population. (PubMed id 16904291)1, 4, 9 Tochigi M....Sasaki T. (Schizophr. Res. 2006)
    8. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. (PubMed id 15567072)1, 4, 9 Chen Q....He L. (Schizophr. Res. 2005)
    9. Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. (PubMed id 11840505)1, 4, 9 MartA- S.B....NAPthen M. (Am. J. Med. Genet. 2002)
    10. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. (PubMed id 8824806)1, 3, 9 Scherer S.W....Tsui L.C. (Genomics 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2913 HGNC: 4595 AceView: GRM3 Ensembl:ENSG00000198822 euGenes: HUgn2913
    ECgene: GRM3 Kegg: 2913 H-InvDB: GRM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRM3 gene:
    Search GeneIP for patents involving GRM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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