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GRM1 Gene

protein-coding   GIFtS: 73
GCID: GC06P146390

Glutamate Receptor, Metabotropic 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Metabotropic 11 2     MGLU12
MGLUR12 3 5     Metabotropic Glutamate Receptor 12
GPRC1A2 3     mGluR13
SCAR132 5     GRM1A5

External Ids:    HGNC: 45931   Entrez Gene: 29112   Ensembl: ENSG000001528227   OMIM: 6044735   UniProtKB: Q132553   

Export aliases for GRM1 gene to outside databases

Previous GC identifers: GC06P145973 GC06P146196 GC06P146330 GC06P143912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRM1 Gene:
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is
the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain
function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded
protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled
phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states,
including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for GRM1 Gene:
GRM1 (glutamate receptor, metabotropic 1) is a protein-coding gene. Diseases associated with GRM1 include spinocerebellar ataxia, autosomal recessive 13, and disuse amblyopia. GO annotations related to this gene include G-protein coupled receptor activity and glutamate receptor activity. An important paralog of this gene is GRM7.

UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the
central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term
depression in the cerebellum

summary for GRM1 Gene:
Metabotropic glutamate (mGlu) group I receptors are members of the metabotropic class of glutamate
receptors, which also includes mGlu group II and mGlu group III receptors. mGlu group I receptors are
divided into two subtypes, mGlu1 and mGlu5. The receptors are coupled to Gq/11 which activates phospholipase
C and they are also associated with Na+ and K+ channels. Their action is generally excitatory, increasing
conductance, causing more glutamate to be released from the presynaptic cell. They can also increase
inhibitory postsynaptic potentials (IPSPs), inhibit glutamate release and can modulate voltage-dependent
calcium channels. Group I mGluRs, unlike other groups, are activated by 3,5-dihydroxyphenylglycine (DHPG),
allowing their function to be isolated. The human genes for mGlu1 and mGlu5 receptors have been localized to
chromosomes 6 (6q24) and 11 (11q14.3) respectively.

Gene Wiki entry for GRM1 (Metabotropic glutamate receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRM1 gene promoter:
         CREB   AML1a   HFH-1   FOXJ2 (long isoform)   HTF   deltaCREB   FOXJ2   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRM1 promoter sequence
   Search Chromatin IP Primers for GRM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24   Ensembl cytogenetic band:  6q24.3   HGNC cytogenetic band: 6q24

GRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRM1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P146390:  view genomic region     (about GC identifiers)

Start:
146,348,782 bp from pter      End:
146,758,734 bp from pter
Size:
409,953 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255 (See protein sequence)
Recommended Name: Metabotropic glutamate receptor 1 precursor  
Size: 1194 amino acids; 132357 Da
Subunit: Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1,
RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity)
1 PDB 3D structure from and Proteopedia for GRM1:
3KS9 (3D)    
Secondary accessions: B9EG79 Q13256 Q14757 Q14758 Q5VTF7 Q5VTF8 Q9NU10 Q9UGS9 Q9UGT0
Alternative splicing: 2 isoforms:  Q13255-1   Q13255-2   (Ref.1 (AAA87844) sequence is in conflict in positions: 896:T->S and 904:V->A)

Explore the universe of human proteins at neXtProt for GRM1: NX_Q13255

Explore proteomics data for GRM1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn98, Asn223, Asn397, Asn515
  • Modification sites at PhosphoSitePlus

  • See GRM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001264993.1  NP_001264994.1  NP_001264995.1  NP_001264996.1  NP_000829.2  

    ENSEMBL proteins: 
     ENSP00000424095   ENSP00000347437   ENSP00000282753   ENSP00000425599   ENSP00000354896  
     ENSP00000376119  
    Reactome Protein details: Q13255

    GRM1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for GRM1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRM1
    GenScript Custom Purified and Recombinant Proteins Services for GRM1
    Novus Biologicals GRM1 Protein
    Novus Biologicals GRM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRM1

    GRM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRM1
    R&D Systems Antibodies for GRM1 (mGluR1a)
    Cell Signaling Technology (CST) Antibodies for GRM1  (mGluR1)
    OriGene Antibodies for GRM1
    OriGene Custom Antibody Services for GRM1
    Novus Biologicals GRM1 Antibodies
    Abcam antibodies for GRM1 (Q13255, P41594)
    Cloud-Clone Corp. Antibodies for GRM1
    ThermoFisher Antibody for GRM1
    LSBio Antibodies in human, mouse, rat for GRM1

    GRM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRM1
    Cloud-Clone Corp. CLIAs for GRM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GR: Glutamate receptors
    GRM: GPCR / Class C : Glutamate receptors, metabotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: mGlu1 receptor
    Metabotropic glutamate receptors

    Selected InterPro protein domains (see all 9):
     IPR011500 GPCR_3_9-Cys_dom
     IPR028082 Peripla_BP_I
     IPR000337 GPCR_3
     IPR017979 GPCR_3_CS
     IPR019588 Metabotropic_Glu_rcpt_Homer-bd

    Graphical View of Domain Structure for InterPro Entry Q13255

    ProtoNet protein and cluster: Q13255

    4 Blocks protein domains:
    IPB000162 Metabotropic glutamate receptor signature
    IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
    IPB001256 Metabotropic glutamate receptor 1 signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255
    Similarity: Belongs to the G-protein coupled receptor 3 family


    GRM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRM1_HUMAN, Q13255
    Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers
    signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
    effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the
    central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term
    depression in the cerebellum

         Genatlas biochemistry entry for GRM1:
    metabotropic glutamate receptor 1,expressed in the brain,G protein coupled receptor superfamily,binding to HOMER
    proteins and linked to inositol phosphate receptors,activating PI turnover and triggering intracellular calcium
    release,

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS7476890
    GO:0005515protein binding IPI19084525
    GO:0008066glutamate receptor activity TAS7476890
         
    GRM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GRM1:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Grm1):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  nervous system  renal/urinary system  reproductive system  skeleton 
     vision/eye 

    GRM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRM1: Grm1tm1Stl Grm1tm1Crpl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRM1:
    hsa-mir-124-3p (MIRT022650)

    Block miRNA regulation of human, mouse, rat GRM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM1 (see all 42):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-139-5p hsa-miR-218 hsa-miR-570 hsa-miR-509-3-5p hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidGRM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRM1
    Predesigned siRNA for gene silencing in human, mouse, rat GRM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRM1

    Clone
    Products:
         
    OriGene clones in human, mouse for GRM1 (see all 13)
    OriGene ORF clones in mouse, rat for GRM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRM1 (NM_000838)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for GRM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRM1_HUMAN, Q13255: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7476890
    GO:0014069postsynaptic density IEA--
    GO:0016021integral component of membrane ----

    GRM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRM1 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    3Glutamic acid signaling
    Glutamic acid signaling
    Synaptic Neurotransmission: Glutamatergic Excitation0.00
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GRM1
        Synaptic Neurotransmission: Glutamatergic Excitation

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRM1
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    CREB Pathway
    Signaling in Gap Junctions

    1 Cell Signaling Technology (CST) Pathway for GRM1
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for GRM1
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    3 BioSystems Pathways for GRM1
        Hypothetical Network for Drug Addiction
    GPCRs, Other
    GPCRs, Class C Metabotropic glutamate, pheromone

    2 Reactome Pathways for GRM1
        G alpha (q) signalling events
    Class C/3 (Metabotropic glutamate/pheromone receptors)


    Selected Kegg Pathways  (Kegg details for GRM1) (see all 9):
        Calcium signaling pathway
    FoxO signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Long-term potentiation


    GRM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM1 (see all 6): 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRM1 (Q132551, 2, 3 ENSP000002827534) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA1P522941, 2, 3, ENSP000003437014EBI-8527352,EBI-358383 MINT-6803357 MINT-6803320 I2D: score=1 STRING: ENSP00000343701
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0000187activation of MAPK activity IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS7476890
    GO:0007268synaptic transmission TAS9076744
    GO:0007626locomotory behavior IEA--

    GRM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for GRM1
      Browse compounds at ApexBio 

    Compounds for GRM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 367385Selective mGlu1a antagonist[198419-91-9]
    MTEP hydrochloride Potent, selective mGlu5 antagonist [1186195-60-7]
    (RS)-3,5-DHPG Selective group I mGlu agonist[19641-83-9]
    MPEP hydrochloridemGlu5 antagonist and positive allosteric modulator at mGlu4[96206-92-7]
    (S)-3,5-DHPG Selective group I mGlu agonist. Active enantiomer of 3,5-DHPG (Cat. No. 0342) [162870-29-3]

    2 HMDB Compounds for GRM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--

    3 DrugBank Compounds for GRM1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid-- --target--17139284 17016423 10592235
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17331504 16751798 17360958
    Acamprosate3-(Acetylamino)propanesulphonic acid (see all 4)77337-76-9targetantagonist17139284 17016423

    10 IUPHAR Ligands for GRM1 (mGlu1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]R214127
    Allosteric regulatorNegative912695537
    R214127
    Allosteric regulatorNegative8.915555631
    9-dimethylamino-3-(4-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
    Allosteric regulatorNegative8.316279797
    A841720
    Allosteric regulatorNegative816279797
    LY341495
    AntagonistAntagonist7.89680254
    LY456236
    Allosteric regulatorNegative6.9--
    (S)-4C3HPG
    AntagonistAntagonist5.8 - 612695537 11080213
    CPCCOEt
    Allosteric regulatorNegative5.210051528
    LY367385
    AntagonistAntagonist5.1--
    AIDA
    AntagonistAntagonist4.29152378

    Selected Novoseek inferred chemical compound relationships for GRM1 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly367385 90 13 15140199 (4), 15182196 (2), 11414795 (1), 19474170 (1) (see all 7)
    glutamate 89.1 381 9692717 (7), 15182196 (6), 11961129 (5), 9639261 (4) (see all 99)
    cpccoet 87.5 12 17292864 (2), 10051528 (1), 10835431 (1), 11414795 (1) (see all 8)
    2-methyl-6-(phenylethynyl)pyridine 82.1 2 12815014 (1), 11880516 (1)
    quisqualate 77.5 15 8093260 (3), 15184361 (2), 8103516 (2), 8528465 (1) (see all 8)
    nmda 69.1 49 16699816 (3), 19403613 (3), 16489129 (2), 11487629 (2) (see all 26)
    ganciclovir 64.8 8 18094230 (1), 19474170 (1), 16023154 (1), 11387401 (1) (see all 8)
    chpg 57.3 1 10428410 (1)
    inositol 1,4,5 trisphosphate 56.9 7 11461909 (1), 12586823 (1), 16234485 (1), 10798399 (1) (see all 7)
    gaba 52.3 6 19415487 (2), 10923987 (1), 16982110 (1), 9065826 (1)



    GRM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRM1 gene (6 alternative transcripts): 
    NM_001278064.1  NM_001278065.1  NM_001278066.1  NM_001278067.1  NM_000838.3  NM_001114329.1  

    Unigene Cluster for GRM1:

    Glutamate receptor, metabotropic 1
    Hs.32945  [show with all ESTs]
    Unigene Representative Sequence: NM_001114329
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507005(uc010khu.1) ENST00000502405 ENST00000492807(uc003qll.2 uc011edz.1 uc011eea.1)
    ENST00000355289 ENST00000282753 ENST00000507907 ENST00000361719(uc010khw.1)
    ENST00000392299(uc010khv.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat GRM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRM1 (see all 42):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-139-5p hsa-miR-218 hsa-miR-570 hsa-miR-509-3-5p hsa-miR-181b hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidGRM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for GRM1
    Predesigned siRNA for gene silencing in human, mouse, rat GRM1
    Clone
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    OriGene clones in human, mouse for GRM1 (see all 13)
    OriGene ORF clones in mouse, rat for GRM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): GRM1 (NM_000838)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRM1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for GRM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRM1
      QuantiTect SYBR Green Assays in human, mouse, rat GRM1
      QuantiFast Probe-based Assays in human, mouse, rat GRM1

    Additional mRNA sequence: 

    AB208837.1 AK308550.1 BC136280.1 BC143777.1 BC143779.1 L76627.1 L76631.1 U31215.1 
    U31216.1 

    2 DOTS entries:

    DT.102836021  DT.87046965 

    19 AceView cDNA sequences:

    L76631 AA322702 AL118996 U31215 NM_000838 BV183579 CD609632 L76627 
    BX477925 U31216 BX954545 CD609625 AV730666 CB990979 CD609630 CD609627 
    CD609624 CD609622 CD609619 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for GRM1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                        
    SP2:                                                        -               


    ECgene alternative splicing isoforms for GRM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATTTTTT
    GRM1 Expression
    About this image


    GRM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    GRM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32945

    UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255
    Tissue specificity: Detected in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRM1 (see all 6): 
              Neurotransmitter Receptors in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              GABA & Glutamate in human mouse rat
              Gap Junctions in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRM1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grm11 , 5 glutamate receptor, metabotropic 11, 5 87.77(n)1
    94.29(a)1
      10 (3.44 cM)5
    148161  NM_016976.31  NP_058672.11 
     106860595 
    chicken
    (Gallus gallus)
    Aves GRM11 glutamate receptor, metabotropic 1 79.11(n)
    87.41(a)
      421614  XM_004935585.1  XP_004935642.1 
    lizard
    (Anolis carolinensis)
    Reptilia GRM16
    glutamate receptor, metabotropic 1
    86(a)
    1 ↔ 1
    1(207222140-207449169)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grm11 glutamate receptor, metabotropic 1 72.1(n)
    81.02(a)
      100495945  XM_002931519.2  XP_002931565.2 
    zebrafish
    (Danio rerio)
    Actinopterygii grm11 glutamate receptor, metabotropic 1 70.56(n)
    74.83(a)
      100150246  XM_001921559.4  XP_001921594.3 
    worm
    (Caenorhabditis elegans)
    Secernentea mgl-26
    Protein MGL-2 (mgl-2) mRNA, complete cds
    38(a)
    1 → many
    I(10384219-10391395) WBGene00003233


    ENSEMBL Gene Tree for GRM1 (if available)
    TreeFam Gene Tree for GRM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRM1 gene
    GRM72  GRM42  TAS1R22  GRM82  TAS1R32  GRM22  GRM32  TAS1R12  
    GRM62  GRM52  GPRC6A2  
    10 SIMAP similar genes for GRM1 using alignment to 2 protein entries:     GRM1_HUMAN (see all proteins):
    GRM5    GRM8    DKFZp686H1993    GRM2    GRM3    GRM7
    GRM4    GRM6    GPCR    CASR

    GRM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRM1 (see all 7598)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361944
    A colorectal cancer sample4--see VAR_0361942 R W mis40--------
    rs1493860641,2
    Cuntested1146349746(+) CAGATC/TGCTTA 8 I syn11Minor allele frequency- T:0.00NA 4550
    rs718801511,2
    C--143912592(+) AGGGA-/GTGT  
            
    GTGTG
    4 -- us2k1 int10--------
    rs1436242311,2
    C--143934145(+) TTTCA-/TATC  
            
    TATCT
    4 -- int10--------
    rs3775376501,2
    C--143934145(+) TTTCA-/TAT   
       CTATC
    TATCT
    4 -- int10--------
    rs2007387311,2
    C--144120248(+) TTACC-/GTGT  
            
    GTGTG
    4 -- int10--------
    rs3733478551,2
    C--144120248(+) GTTAC-/GTTGTGT 4 -- int10--------
    rs786132411,2
    C--144133897(+) CATGGC/GCCGGG 4 -- int10--------
    rs113431981,2
    C--144233733(+) GGCTA-/TTTTTT 4 -- int1 trp32Minor allele frequency- T:0.25NA CSA 4
    rs111554641,2
    C,A,H--144233747(+) TTTTAA/TTTTTT 4 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for GRM1 (146348782 - 146598782 bp, first 250kb of GRM1)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for GRM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669145CNV Deletion23128226
    esv2660189CNV Deletion23128226
    esv28078CNV Loss19812545
    nsv527571CNV Loss19592680
    nsv482962CNV Loss15286789
    esv32685CNV Loss17666407
    nsv886749CNV Gain21882294
    nsv830836CNV Gain17160897

    Human Gene Mutation Database (HGMD): GRM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRM1
    DNA2.0 Custom Variant and Variant Library Synthesis for GRM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604473   
    OMIM disorders: 614831  
    UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255
  • Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13) [MIM:614831]: Spinocerebellar ataxia is a
    clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination
    of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum
    with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor
    development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or
    absent speech as well as gait and stance ataxia and hyperreflexia. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for GRM1 (see all 49):    
    About MalaCards
    spinocerebellar ataxia, autosomal recessive 13    disuse amblyopia    amblyopia    hypothalamic hamartomas
    bipolar disorder    periventricular leukomalacia    leukomalacia    central precocious puberty
    cerebellar ataxia    psychotic disorder    precocious puberty    drug addiction
    hypercalcemia    schizophrenia    fragile x syndrome    pick's disease
    temporal lobe epilepsy    ataxia    breast cancer    albinism

    2 diseases from the University of Copenhagen DISEASES database for GRM1:
    Fragile X syndrome     Disuse amblyopia

    GRM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for GRM1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypocalcemia, autosomal dominant 81.3 1 12890593 (1)
    neurodegenerative diseases 31.3 1 10668448 (1)
    cns diseases 30.6 3 16178731 (1)
    epilepsy temporal lobe 20.7 3 17446080 (2), 10744030 (1)
    neurodegeneration 18 2 17265692 (1), 10530809 (1)
    epilepsy 15.7 2 16563443 (2)
    parkinson disease 9.04 1 11786307 (1)
    schizophrenia 4.93 3 15945063 (2), 16699816 (1)
    necrosis 4.04 1 17168764 (1)
    tumors 1.58 2 17168764 (1), 20061814 (1)

    Genetic Association Database (GAD): GRM1
    Human Genome Epidemiology (HuGE) Navigator: GRM1 (13 documents)

    Export disorders for GRM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRM1 gene, integrated from 10 sources (see all 340):
    (articles sorted by number of sources associating them with GRM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants. (PubMed id 9076744)1, 2, 3, 9 Stephan D.... Pruss R.M. (Neuropharmacology 1996)
    2. Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. (PubMed id 10945991)1, 2, 9 Ray K. and Hauschild B.C. (J. Biol. Chem. 2000)
    3. Expression of a novel splice variant of human mGluR1 in the cerebellum. (PubMed id 9376535)1, 3, 9 Makoff A.J....Emson P. (Neuroreport 1997)
    4. Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1. (PubMed id 22901947)1, 2 Guergueltcheva V.... Kalaydjieva L. (Am. J. Hum. Genet. 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    8. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    9. Genetic analysis of the GRM1 gene in human melanoma susceptibility. (PubMed id 17609672)1, 4 Ortiz P....Real L.M. (Eur. J. Hum. Genet. 2007)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2911 HGNC: 4593 AceView: GRM1 Ensembl:ENSG00000152822 euGenes: HUgn2911
    ECgene: GRM1 Kegg: 2911 H-InvDB: GRM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GRM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRM1 gene:
    Search GeneIP for patents involving GRM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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