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GRM1 Gene

protein-coding GIFtS: 69

GC06P146390

glutamate receptor, metabotropic 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GPRC1A ^¹, ², ³
GRM1A ^², ⁵
MGLUR1 ^¹, ², ³, ⁵
MGLUR1A ^²
OTTHUMP00000017365 ^²
mGlu1 ^¹, ²
mGluR1 ^³

Descriptions
glutamate receptor, metabotropic 1 ^²

External Ids
HGNC: 4593¹
Entrez Gene: 2911²
UniProtKB: Q13255³
Ensembl: ENSG00000152822⁷

Search outside databases for aliases for GRM1 gene

Previous GC identifers: GC06P145973 GC06P146196 GC06P146330

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRM1:

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates

both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved

in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.

The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been

divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms,

and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown

to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6,

GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade

but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic

glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a

G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing

results in multiple transcript variants encoding distinct isoforms; some of which may have

distinct functions. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255

Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that

activates a phosphatidylinositol-calcium second messenger system. May participate in the central

action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term

depression in the cerebellum

Gene Wiki entry for GRM1 (Metabotropic_glutamate_receptor_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRM1 gene

Entrez Gene cytogenetic band: 6q24 Ensembl cytogenetic band: 6q24.3 HGNC cytogenetic band: 6q24

GRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P146390: (about GC identifiers)

Start:	146,390,611 bp from pter
End:	146,800,427 bp from pter
Size:	409,817 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255 (See protein sequence)

Recommended Name: Metabotropic glutamate receptor 1 precursor

Size: 1194 amino acids; 132367 Da

Subunit: Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts

with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q13256 Q14757 Q14758 Q5VTF7 Q5VTF8 Q9NU10 Q9UGS9 Q9UGT0

Alternative splicing: 2 isoforms: Q13255-1 Q13255-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000829.2 NP_001107801.1

ENSEMBL proteins:

ENSP00000282753 ENSP00000376119 ENSP00000347437

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Metabotropic Glutamate Receptor 5+1, Metabotropic Glutamate Receptor 1, Metabotropic Glutamate Receptor 1a)
	Human Recombinant Proteins from Abnova (GRM1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	7476890

About this table

Antibodies for GRM1:

	Invitrogen Antibodies for GRM1
	Millipore Mono- and Polyclonal Antibodies for the study of GRM1
	Sigma-Aldrich Antibodies for GRM1
	R&D Systems Antibodies for GRM1 (mGluR1a)
	Antibodies from Abcam (Metabotropic Glutamate Receptor 5+1, Metabotropic Glutamate Receptor 1, Metabotropic Glutamate Receptor 1a), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GRM1)
	Novus Biologicals Antibodies for GRM1

Assays for GRM1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13255

ProtoNet protein and cluster: Q13255

4 Blocks protein families:

IPB000162 Metabotropic glutamate receptor signature

IPB000337 G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)

IPB001256 Metabotropic glutamate receptor 1 signature

IPB001828 Extracellular ligand-binding receptor

UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255

Similarity: Belongs to the G-protein coupled receptor 3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000838

Applied Biosystems Silencer® siRNAs for GRM1

Sigma-Aldrich siRNA and siRNA Panels for GRM1

Sigma-Aldrich shRNA Panels and shRNA for GRM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000838
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000838
untagged cDNA clones in CMV expression vector (see all 2): NM_000838

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000838

UniProtKB/Swiss-Prot: GRM1_HUMAN, Q13255

Function: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that

activates a phosphatidylinositol-calcium second messenger system. May participate in the central

action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term

depression in the cerebellum

Genatlas biochemistry entry for GRM1:

metabotropic glutamate receptor 1,expressed in the brain,G protein coupled receptor

superfamily,binding to HOMER proteins and linked to inositol phosphate receptors,activating PI

turnover and triggering intracellular calcium release,

9 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Grm1):

adipose tissue	behavior/neurological	growth/size	life span-post-weaning/aging	muscle
nervous system	reproductive system	skeleton	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	7476890
GO:0008066	glutamate receptor activity	TAS	7476890

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GRM1 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Huntington's Disease Signaling
CREB Signaling in Neurons
Synaptic Long Term Depression
G-Protein Coupled Receptor Signaling
Glutamate Receptor Signaling

GeneDecks GRM1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GRM1

5/46 Interacting proteins for GRM1 (ENSP00000282753³ Q13255²) via UniProtKB, MINT, and/or STRING (see all 46 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KPNA1	P52294²	MINT-6803357 MINT-6803320
KPNA3	O00505²	MINT-6803333
HOMER1	ENSP00000334382³	STRING (score=.986)
HOMER2	ENSP00000305632³	STRING (score=.982)
ADRBK1	ENSP00000312262³	STRING (score=.978)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	7476890
GO:0007268	synaptic transmission	TAS	9076744

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRM1

Sigma-Aldrich Small Molecules for GRM1:

Antagonist Agonist Allosteric Modulator

Compounds for GRM1 available from Tocris Bioscience

Compound	Action	CAS number
YM 298198 hydrochloride	Highly potent, selective non-competitive mGlu1 antagonist	[748758-45-4]
CPCCOEt	Selective non-competitive mGlu1 receptor antagonist	[179067-99-3]
JNJ 16259685	Extremely potent, mGlu1-selective non-competitive antagonist	[409345-29-5]
LY 367385	Selective mGlu1a antagonist	[198419-91-9]
A 841720	Selective mGlu1 antagonist	[869802-58-4]

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10/17 Novoseek chemical compound relationships for GRM1 gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cpccoet	87.29	11	17292864 (2), 10051528 (1), 10835431 (1), 11414795 (1) (see all 7)
chpg	58.79	1	10428410 (1)
inositol 1,4,5 trisphosphate	55.40	7	11461909 (1), 12586823 (1), 16234485 (1), 10798399 (1) (see all 7)
phosphoinositide	50.41	21	7964721 (5), 8843493 (3), 7931274 (2), 8513133 (1) (see all 7)
calcium	50.10	45	12704197 (5), 12653978 (2), 10617111 (2), 16763042 (2) (see all 26)
ryanodine	31.64	2	9749760 (1)
proline	8.58	1	9076744 (1)
tyrosine	5.93	2	9692717 (1), 10617111 (1)
isoleucine	4.30	1	10639281 (1)
potassium	4.03	2	8093260 (1), 9665131 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000838

Sigma-Aldrich siRNA and siRNA Panels for GRM1

Sigma-Aldrich shRNA Panels and shRNA for GRM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000838 NM_001114329

REFSEQ mRNAs for GRM1 gene (2 alternative transcripts):

NM_000838.3 NM_001114329.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000838 NM_001114329

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000838
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000838
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000838

Additional cDNA sequence:

AB208837.1 AK308550.1 BC136280.1 BC143777.1 BC143779.1 L76627.1 L76631.1 U31215.1

U31216.1

2 DOTS entries:

DT.102836021 DT.87046965

19 AceView cDNA sequences:

AL118996 L76631 AA322702 BX477925 L76627 CD609632 BX954545 NM_000838

U31215 U31216 BV183579 CD609630 AV730666 CB990979 CD609625 CD609627

CD609619 CD609622 CD609624

highest scoring ESTs for GRM1:

L76627 U31216 AA322702 AL118996 AV730666 BX477925 CB990979 M79013 M79016 CD609619

Unigene Cluster for GRM1:

Glutamate receptor, metabotropic 1

Hs.32945 [show with all ESTs]

Unigene Representative Sequence: NM_001114329

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for GRM1

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:
SP2:																			-

About this scheme

ECgene alternative splicing isoforms for GRM1

3 Ensembl transcripts including schematic representations:

ENST00000282753 ENST00000392299 ENST00000355289

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GRM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRM1

¹ / ² / ³

9 probe-sets matching GRM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33509_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.80	L76627	1.00	0.87	0.94	1
33510_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.10	1.67	U31216	1.00	0.87	0.94	1
31468_f_at²^{, 3}	U95-A	2	1.00	0.97	0.60	0.69	W26104	0.40	1.00	0.76	1
210939_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L76631	0.80	0.83	0.82	1
207299_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000838	0.60	1.00	0.82	1
210940_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U31216	1.00	0.87	0.94	1
210939_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207299_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210940_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRM1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTATTTTTT

SOURCE GeneReport for Unigene cluster: Hs.32945
Expression variation in blood from EXPOLDB for GRM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRM1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRM1¹	--	glutamate receptor, metabotropic 1	92.45(n) 96.13(a)	484024 XM_845272.1 XP_850365.1
chimpanzee (Pan troglodytes)	GRM1¹	--	glutamate receptor, metabotropic 1	99.61(n) 99.92(a)	463049 XM_518785.2 XP_518785.2
cow (Bos taurus)	GRM1¹	--	glutamate receptor, metabotropic 1	90.66(n) 94.44(a)	540485 XM_611688.3 XP_611688.3
rat (Rattus norvegicus)	Grm1¹	--	glutamate receptor, metabotropic 1	88.83(n) 95.13(a)	24414 NM_017011.1 NP_058707.1
mouse (Mus musculus)	Grm1^{1, 5}	10 (3.00 cM)⁵	glutamate receptor, metabotropic 1^{1, 5}	88.22(n)¹ 94.96(a)¹	14816¹ NM_016976.1¹ NP_058672.1¹ AF320126⁵ AK132901⁵ (see all 9)

About this table Species with no ortholog for GRM1

ENSEMBL Gene Tree for GRM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRM1 gene

GRM5² ENSG00000205035²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1739 NCBI SNPs in GRM1 are shown (see all 1739 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 737)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2073287^1,2	A,C,F,H,O	146391957(-)	`GGTCTA/GTAATG`	1	--	ng5¹		12	EA NA EU WA	2450
	rs362822^1,2	A,C,F,H,O	146800235(+)	`TAGTCC/TTTATG`	2	--	ut3¹ ese³		9	MN EA NA EU WA	2218
	rs3811105^1,2	A,C,F,H	146391444(+)	`TACCAA/GACTCC`	1	--	ng5¹		4	EU EA WA	414
--	rs3804293^1,2	A,C,F,H	146798904(-)	`TTGACA/CAGTCA`	2	--	ut3¹ ese³		4	EU EA WA	412
	rs6923492^1,2	A,C,F,H	146797017(+)	`TGCCGC/TCCCAC`	2	S/P	mis¹ ut3¹ ese³		8	EU EA WA	832
--	rs2942^1,2	A,C,F,H	146796833(+)	`ATCAAA/GCCCCT`	2	K/K	syn¹ ut3¹ ese³		8	MN NA EU EA WA	736
--	rs1331634^1,2	A,C,F,H	146391098(-)	`acacaC/Tacaca`	1	--	ng5¹		4	EU EA WA	412
	rs362820^1,2	A,C,F,H	146798995(+)	`GTTTTA/GTACAT`	2	--	ut3¹ ese³		6	EA MN EU WA	2032
	rs9373491^1,2	A,C,F,H	146797535(+)	`TCCCCA/CGTGTC`	2	P/P	syn¹ ut3¹ ese³		7	NA EU EA WA	556
	rs362819^1,2	A,C,F,H	146798262(+)	`TCCACC/TGCAAC`	2	--	ut3¹ ese³		6	EA MN EU WA	2094

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HapMap Linkage Disequilibrium images for GRM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604473

10/15 Novoseek disease relationships for GRM1 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypocalcemia, autosomal dominant	81.92	1	12890593 (1)
neurodegenerative diseases	31.97	1	10668448 (1)
cns diseases	26.64	3	16178731 (1)
epilepsy temporal lobe	23.20	3	17446080 (2), 10744030 (1)
neurodegeneration	21.37	2	17265692 (1), 10530809 (1)
epilepsy	18.44	2	16563443 (2)
parkinson disease	12.43	1	11786307 (1)
necrosis	4.57	1	17168764 (1)
schizophrenia	3.13	3	15945063 (2), 16699816 (1)
tumors	0.77	1	17168764 (1)

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Human Genome Epidemiology Navigator: GRM1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/241 PubMed articles for GRM1 gene (see all 241 ):

Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants. (PubMed id 9076744)^{1, 2, 3, 4} Stephan D.... Pruss R.M. (1996)
Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. (PubMed id 10945991)^{1, 3, 4} Ray K. and Hauschild B.C. (2000)
Expression of a novel splice variant of human mGluR1 in the cerebellum. (PubMed id 9376535)^{1, 2, 3} Makoff A.J....Emson P. (1997)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. (PubMed id 7476890)^{3, 4} Desai M.A.... Schoepp D.D. (1995)
Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins. (PubMed id 11961129)^{1, 3} Mundell S.J....Kelly E. (2002)
Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop. (PubMed id 15870073)^{1, 3} Dhami G.K....Ferguson S.S. (2005)
Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor. (PubMed id 17430891)^{1, 3} Crepaldi L....Ferraguti F. (2007)
The human immunodeficiency virus-1 protein transactivator of transcription up-regulates N-methyl-D-aspartate receptor function by acting at metabotropic glutamate receptor 1 receptors coexisting on human and rat brain noradrenergic neurones. (PubMed id 16489129)^{1, 3} Longordo F....Pittaluga A. (2006)
Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptors 1a and 1b. (PubMed id 15155843)^{1, 3} Mundell S.J....Kelly E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2911	HGNC: 4593	AceView: GRM1	Ensembl:ENSG00000152822	euGenes: HUgn2911
ECgene: GRM1	H-InvDB: GRM1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GRM1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GRM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRM1		Antibodies for GRM1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRM1		Small molecules for GRM1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GRM1)
	Antibodies (GRM1)
	Chimera RNAi (GRM1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Metabotropic Glutamate Receptor 5+1, Metabotropic Glutamate Receptor 1, Metabotropic Glutamate Receptor 1a)
	Antibodies (Metabotropic Glutamate Receptor 5+1, Metabotropic Glutamate Receptor 1, Metabotropic Glutamate Receptor 1a)

Search OriGene for GRM1

Tocris compounds for GRM1

	Drugs for GRM1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRM1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GRM1 Gene at Home site.
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GRM1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for GRM1

Summaries
for GRM1

Genomic Location
for GRM1

Proteins
for GRM1

Protein Domains/
Families
for GRM1

Gene Function
for GRM1

Pathways & Interactions
for GRM1

Drugs & Compounds
for GRM1

Transcripts
for GRM1

Expression
for GRM1

Orthologs
for GRM1

Paralogs
for GRM1

SNPs/Variants
for GRM1

Disorders & Mutations
for GRM1

Medical News
for GRM1

Publications
for GRM1

Search for GRM1

Genome Databases showing GRM1

Other Databases showing GRM1

Specialized Databases showing GRM1

Licensable Technologies
for GRM1

Services
for GRM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRM1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GRM1

Summariesfor GRM1

Genomic Locationfor GRM1

Proteinsfor GRM1

Protein Domains/Familiesfor GRM1

Gene Functionfor GRM1

Pathways & Interactionsfor GRM1

Drugs & Compoundsfor GRM1

Transcriptsfor GRM1

Expression for GRM1

Orthologsfor GRM1

Paralogsfor GRM1

SNPs/Variantsfor GRM1

Disorders & Mutationsfor GRM1

Medical Newsfor GRM1

Publicationsfor GRM1

Search for GRM1

Genome Databases showing GRM1

Other Databases showing GRM1

Specialized Databases showing GRM1

Licensable Technologiesfor GRM1

Servicesfor GRM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRM1

Summaries
for GRM1

Genomic Location
for GRM1

Proteins
for GRM1

Protein Domains/
Families
for GRM1

Gene Function
for GRM1

Pathways & Interactions
for GRM1

Drugs & Compounds
for GRM1

Transcripts
for GRM1

Expression
for GRM1

Orthologs
for GRM1

Paralogs
for GRM1

SNPs/Variants
for GRM1

Disorders & Mutations
for GRM1

Medical News
for GRM1

Publications
for GRM1

Licensable Technologies
for GRM1

Services
for GRM1