Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRK7 Gene

Aliases for GRK7 Gene

  • G Protein-Coupled Receptor Kinase 7 2 3
  • G Protein-Coupled Receptor Kinase GRK7 3 4
  • EC 2.7.11.16 4 63
  • GPRK7 3 4
  • EC 2.7.11.14 4
  • EC 2.7.11 63

External Ids for GRK7 Gene

Previous HGNC Symbols for GRK7 Gene

  • GPRK7

Previous GeneCards Identifiers for GRK7 Gene

  • GC03P142817
  • GC03P142979
  • GC03P141496
  • GC03P138870

Summaries for GRK7 Gene

Entrez Gene Summary for GRK7 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRK7 Gene

GRK7 (G Protein-Coupled Receptor Kinase 7) is a Protein Coding gene. Diseases associated with GRK7 include enhanced s-cone syndrome. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for GRK7 Gene

  • Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRK7 Gene

Genomics for GRK7 Gene

Regulatory Elements for GRK7 Gene

Genomic Location for GRK7 Gene

Chromosome:
3
Start:
141,749,984 bp from pter
End:
141,818,490 bp from pter
Size:
68,507 bases
Orientation:
Plus strand

Genomic View for GRK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GRK7 Gene

Proteins for GRK7 Gene

  • Protein details for GRK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTQ7-GRK7_HUMAN
    Recommended name:
    G protein-coupled receptor kinase 7
    Protein Accession:
    Q8WTQ7

    Protein attributes for GRK7 Gene

    Size:
    553 amino acids
    Molecular mass:
    62212 Da
    Quaternary structure:
    • Interacts (when prenylated) with PDE6D; this promotes release from membranes.
    Miscellaneous:
    • Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist

neXtProt entry for GRK7 Gene

Proteomics data for GRK7 Gene at MOPED

Selected DME Specific Peptides for GRK7 Gene

Post-translational modifications for GRK7 Gene

  • Autophosphorylated in vitro at Ser-490. Phosphorylation at Ser-36 is regulated by light and activated by cAMP.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRK7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for GRK7 Gene

Suggested Antigen Peptide Sequences for GRK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTQ7

UniProtKB/Swiss-Prot:

GRK7_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 RGS domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
genes like me logo Genes that share domains with GRK7: view

Function for GRK7 Gene

Molecular function for GRK7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.9 uM for rhodopsin {ECO:0000269 PubMed:15946941}; KM=21.4 uM for ATP {ECO:0000269 PubMed:15946941}; Vmax=915 nmol/min/mg enzyme {ECO:0000269 PubMed:15946941};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by phosphorylation of Ser-36.
UniProtKB/Swiss-Prot Function:
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

Enzyme Numbers (IUBMB) for GRK7 Gene

Gene Ontology (GO) - Molecular Function for GRK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004703 G-protein coupled receptor kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0050254 rhodopsin kinase activity IDA 15946941
genes like me logo Genes that share ontologies with GRK7: view
genes like me logo Genes that share phenotypes with GRK7: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRK7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GRK7 Gene

Localization for GRK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRK7 Gene

Membrane; Lipid-anchor.

Gene Ontology (GO) - Cellular Components for GRK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0097381 photoreceptor disc membrane TAS --
genes like me logo Genes that share ontologies with GRK7: view

No data available for Subcellular locations from COMPARTMENTS for GRK7 Gene

Pathways & Interactions for GRK7 Gene

genes like me logo Genes that share pathways with GRK7: view

Gene Ontology (GO) - Biological Process for GRK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007165 signal transduction --
GO:0007601 visual perception IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0016056 rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with GRK7: view

No data available for SIGNOR curated interactions for GRK7 Gene

Drugs & Compounds for GRK7 Gene

(2) Drugs for GRK7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for GRK7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with GRK7: view

Transcripts for GRK7 Gene

mRNA/cDNA for GRK7 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRK7 Gene

G protein-coupled receptor kinase 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRK7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRK7 Gene

No ASD Table

Relevant External Links for GRK7 Gene

GeneLoc Exon Structure for
GRK7
ECgene alternative splicing isoforms for
GRK7

Expression for GRK7 Gene

mRNA expression in normal human tissues for GRK7 Gene

mRNA differential expression in normal tissues according to GTEx for GRK7 Gene

This gene is overexpressed in Muscle - Skeletal (x4.0).

Protein differential expression in normal tissues from HIPED for GRK7 Gene

This gene is overexpressed in Breast (46.0), Plasma (13.1), and Retina (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRK7 Gene



SOURCE GeneReport for Unigene cluster for GRK7 Gene Hs.680654

mRNA Expression by UniProt/SwissProt for GRK7 Gene

Q8WTQ7-GRK7_HUMAN
Tissue specificity: Retinal cones, outer and inner segments.
genes like me logo Genes that share expression patterns with GRK7: view

Protein tissue co-expression partners for GRK7 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GRK7 Gene

Orthologs for GRK7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRK7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRK7 35
  • 86.78 (n)
  • 86.05 (a)
GRK7 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC485693 35
  • 87.34 (n)
  • 85.71 (a)
GRK7 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRK7 35
  • 99.28 (n)
  • 99.46 (a)
GRK7 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRK7 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRK7 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRK7 35
  • 71.83 (n)
  • 73.41 (a)
GRK7 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRK7 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grk7 35
  • 66.91 (n)
  • 69.58 (a)
zebrafish
(Danio rerio)
Actinopterygii grk7a 35
  • 63.59 (n)
  • 61.62 (a)
grk7a 36
  • 60 (a)
OneToMany
grk7b 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gprk1 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grk-2 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for GRK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRK7 Gene

ENSEMBL:
Gene Tree for GRK7 (if available)
TreeFam:
Gene Tree for GRK7 (if available)

Paralogs for GRK7 Gene

(10) SIMAP similar genes for GRK7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRK7: view

Variants for GRK7 Gene

Sequence variations from dbSNP and Humsavar for GRK7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1055893 -- 141,755,669(+) ttaaa(A/G/T)agact intron-variant
rs1320310 -- 141,802,981(+) ATAGA(A/G)CAAAG intron-variant
rs1467200 -- 141,784,322(+) TCTGC(A/G)TCCCT intron-variant
rs1467201 -- 141,785,442(+) TAGTG(A/C)GAACC intron-variant
rs1467202 -- 141,785,464(+) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRK7 Gene

Variant ID Type Subtype PubMed ID
nsv819618 CNV Gain 19587683

Variation tolerance for GRK7 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRK7 Gene

HapMap Linkage Disequilibrium report
GRK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRK7 Gene

Disorders for GRK7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRK7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
enhanced s-cone syndrome
  • enhanced s cone dystrophy
- elite association
Search GRK7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRK7

Genetic Association Database (GAD)
GRK7
Human Genome Epidemiology (HuGE) Navigator
GRK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRK7
genes like me logo Genes that share disorders with GRK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRK7 Gene

Publications for GRK7 Gene

  1. Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction. (PMID: 11717351) Weiss E.R. … Osawa S. (J. Neurosci. 2001) 2 23 67
  2. Characterization of human GRK7 as a potential cone opsin kinase. (PMID: 11754336) Chen C.-K. … Baehr W. (Mol. Vis. 2001) 2 23 67
  3. Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin. (PMID: 18266817) Torisawa A. … Kawamura S. (Photochem. Photobiol. 2008) 23 67
  4. Cone deactivation kinetics and GRK1/GRK7 expression in enhanced S cone syndrome caused by mutations in NR2E3. (PMID: 12601058) Cideciyan A.V. … Milam A.H. (Invest. Ophthalmol. Vis. Sci. 2003) 23 67
  5. Identification of additional members of human G-protein-coupled receptor kinase multigene family. (PMID: 8415712) Haribabu B. … Snyderman R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 23 67

Products for GRK7 Gene

Sources for GRK7 Gene

Back to Top

Content