GRK6 Gene
protein-coding GIFtS: 62
GCID: GC05P176853
|
|
G protein-coupled receptor kinase 6
(Previous symbol: GPRK6)
| |
Aliases
for GRK6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor Kinase 61 2 | | GPRK61 2 3 5 | | EC 2.7.11.163 8 | | G Protein-Coupled Receptor Kinase GRK63 | | EC 2.7.118 |
Export aliases for GRK6 gene to outside databasesPrevious GC identifers: GC05P176834 GC05P176786 GC05P171774 |
Summaries
for GRK6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRK6:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily ofthe Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thusinitiating their deactivation. Several transcript variants encoding different isoforms have been described for thisgene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylationinitiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to theirdesensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokinereceptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO)(in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro)
Gene Wiki entry for GRK6
|
Genomic Views
for GRK6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRK6 gene promoter:
Oct-B1 GR oct-B3 oct-B2 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 GR-alpha ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRK6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRK6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35GRK6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P176853: view genomic region
(about GC identifiers)
Start:
|
176,830,205 bp from pter |
End:
|
176,869,902 bp from pter |
Size:
|
39,698 bases |
Orientation:
|
plus strand |
|
Proteins
for GRK6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250 (See
protein sequence)Recommended Name: G protein-coupled receptor kinase 6 Size: 576 amino acids; 65991 Da
Subcellular location: Membrane; Lipid-anchor
3 PDB 3D structures from  and Proteopedia  for GRK6:2ACX (3D)
3NYN (3D)
3NYO (3D)
Secondary accessions: O60541 Q13652Alternative splicing: 3 isoforms: P43250-1 P43250-2 P43250-3 Explore the universe of human proteins at neXtProt for GRK6: NX_P43250
Post-translational modifications:
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-5651
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43250
4/22 DME Specific Peptides for GRK6 (P43250) (see all 22)
GRK6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001004105.1 NP_001004106.1 NP_002073.2
ENSEMBL proteins: ENSP00000422873 ENSP00000421055 ENSP00000425391 ENSP00000347655 ENSP00000427581 ENSP00000377204 ENSP00000348230 ENSP00000433511 ENSP00000422342 ENSP00000423174
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- |
GRK6 for ontologies About GeneDecksing
GRK6 Antibody Products:
Assay Products for GRK6: |
Protein
Domains /
Families
for GRK6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRK6 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry P43250ProtoNet protein and cluster: P43250 3 Blocks protein families: IPB000239 GPCR kinase signature IPB000342 Regulator of G-protein signalling (RGS) protein signature IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 RGS domain |
Function
for GRK6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylationinitiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to theirdesensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokinereceptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO)(in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro)Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphateEnzyme Numbers (IUBMB): EC 2.7.11.161 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRK6 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRK6 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): GRK6 (NM_001004106) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRK6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRK6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004703 | G-protein coupled receptor kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
GRK6 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for GRK6:
Animal Models:
Mouse knock-out Grk6tm1.1Mca for GRK6
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Grk6):
GRK6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GRK6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development Angiotensin signaling via beta-Arrestin | | | 2 | Chemokine Signaling | | | 3 | Calcium Regulation in the Cardiac Cell | | | 4 | Lymphocyte Signaling | | | 5 | FSH signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for GRK6
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRK6
2 
Cell Signaling Technology (CST) Pathways for GRK6
1  GeneGo (Thomson Reuters) Pathway for GRK6
4  BioSystems Pathways for GRK6
2 
Kegg Pathways (Kegg details for GRK6):
GRK6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRK6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/40 Interacting proteins for GRK6 (P432502, 3 ENSP000003772044) via UniProtKB, MINT, STRING, and/or I2D (see all 40)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
-- | -- | | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
TAS | 8077221 | | GO:0016055 | Wnt receptor signaling pathway |
IEA | -- | | GO:0038032 | termination of G-protein coupled receptor signaling pathway |
IEA | -- |
GRK6 for ontologies About GeneDecksing
|
Drugs & Compounds
for GRK6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GRK6 for compounds About GeneDecksing
 Browse Tocris compounds for GRK6
10/11 Novoseek chemical compound relationships for GRK6 gene (see all 11) About this table
Search CenterWatch for drugs/clinical trials and news about GRK6
|
Transcripts
for GRK6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRK6 gene (3 alternative transcripts): NM_001004105.2 NM_001004106.2 NM_002082.3 Unigene Cluster for GRK6: G protein-coupled receptor kinase 6 Hs.235116 [show with all ESTs]Unigene Representative Sequence: NM_00208211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000502598 ENST00000506296 ENST00000511244 ENST00000355472(uc003mgq.2 uc021yit.1 uc021yiu.1)
ENST00000507633 ENST00000393576 ENST00000355958 ENST00000528793 ENST00000512684
ENST00000515666(uc003mgs.1) ENST00000508705
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRK6 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRK6 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): GRK6 (NM_001004106) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRK6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRK6 |
Additional cDNA sequence: AF040751.1 AF040752.1 AK056697.1 BC009277.2 BC017272.1 L16862.1 U00686.1 14 DOTS entries: DT.92071943 DT.116496 DT.100779329 DT.100779327 DT.92071949 DT.95335419 DT.100036878 DT.120810890 DT.100692208 DT.120810841 DT.100666518 DT.86854742 DT.100755217 DT.92424234 24/274 AceView cDNA sequences (see all 274): BM823722 BM697499 AI952074 BQ427844 BQ225134 BX404586 C03418 BQ002152 BM782684 AW249831 BQ061148 AW016924 AF040752 NM_001004106 NM_002082 BM699704 CR619325 AI702855 BQ685752 BM564486 BE297283 BE467925 BQ057469 BM563617
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GRK6 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for GRK6
|
Expression
for GRK6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRK6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCCAGCAA
About this image
See GRK6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRK6
SOURCE GeneReport for Unigene cluster: Hs.235116
UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for GRK6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRK6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRK6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRK6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRK6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK6 |
Orthologs
for GRK6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GRK6 gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Grk61 , 5 |
G protein-coupled receptor kinase 61, 5 |
89.53(n)1
95.93(a)1 |
|
13 (30.06 cM)5
263851 NM_001038018.31 NP_001033107.11
554453345 |
chicken
(Gallus gallus) |
Aves |
GRK61 |
G protein-coupled receptor kinase 6 |
79.9(n)
87.12(a) |
|
416361 XM_414676.3 XP_414676.3 |
lizard
(Anolis carolinensis) |
Reptilia |
GRK66 |
-- |
82(a) |
1 ↔ 1 |
2(145813771-145844368) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.73102 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.8(n) |
|
BX849055.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.257542 |
Transcribed sequence with moderate similarity to protein more |
78.95(n) |
|
AL924239.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Gprk26 |
G protein-coupled receptor kinase 2 |
48(a) |
1 → many |
3R(27230971-27283499) |
worm
(Caenorhabditis elegans) |
Secernentea |
grk-16 |
G protein-coupled receptor kinase 1 |
52(a) |
1 → many |
X(9991799-9999120) |
ENSEMBL Gene Tree for GRK6 (if available)
TreeFam Gene Tree for GRK6 (if available) |
Paralogs
for GRK6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRK6 gene
- GRK72 ADRBK22 GRK52 GRK12 ADRBK12 GRK42
18/52 SIMAP similar genes for GRK6 using alignment to 9 protein entries: GRK6_HUMAN (see all proteins)
(see all similar genes):GRK5 GRK4 GRK1 GRK7 RPS6KA2 PRKCH
BRAF CDK7 MARK4 PKN2 PRKY AKT2
RPS6KB2 AKT3 NEK6 NEK9 STK11 TYK2
GRK6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for GRK6
PGOHUM00000248520
|
Genomic Variants
for GRK6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRK6 (176830205 - 176869902 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for GRK6
3 CNVs: 53135 51643 30224 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRK6 |
|
Disorders
/ Diseases
for GRK6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRK6 for disorders About GeneDecksing
OMIM gene information: 600869
OMIM disorders: --
14  diseases for GRK6: About MalaCardswhim syndrome anorexia nervosa allergic encephalomyelitis encephalomyelitis
huntington's disease multiple myeloma kidney disease skin cancer
parkinson's disease myeloma neuroblastoma neuronitis
carcinoma colorectal cancer
4 Novoseek disease relationships for GRK6 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| huntington disease |
16.5 |
2 |
8415712 (2) |
| encephalomyelitis |
16.1 |
1 |
12667650 (1) |
| inflammation |
0 |
2 |
14634128 (2) |
| melanoma |
0 |
3 |
15650023 (2), 17130136 (1) |
Human Genome Epidemiology (HuGE) Navigator: GRK6 (5 documents)
Export disorders for GRK6 gene to outside databases
|
Publications
for GRK6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRK6 gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with GRK6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of additional members of human G-protein-coupled receptor kinase multigene family. (PubMed id 8415712)1, 2, 3, 9 Haribabu B. and Snyderman R. (1993)
- The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. (PubMed id 16613860)1, 2, 9 Lodowski D.T.... Tesmer J.J. (2006)
- Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. (PubMed id 7961702)1, 2, 9 Stoffel R.H.... Inglese J. (1994)
- Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. (PubMed id 8366096)1, 2, 9 Benovic J.L. and Gomez J. (1993)
- The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. (PubMed id 10506199)1, 2, 9 Premont R.T....Lefkowitz R.J. (1999)
- G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. (PubMed id 19801552)1, 2 Chen M....Chen W. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. (PubMed id 9819198)1, 9 Stoffel R.H....Premont R.T. (1998)
- Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. (PubMed id 9341194)1, 9 Loudon R.P. and Benovic J.L. (1997)
- Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells. (PubMed id 10334944)1, 9 Milcent M.D....Boulay F. (1999)
|
External Searches for GRK6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing GRK6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing GRK6 gene
(According to HUGE)
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Specialized Databases showing GRK6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for GRK6 gene:
Search GeneIP for patents involving GRK6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GRK6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for GRK6 | | OriGene shRNA RFP for GRK6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRK6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRK6 | | | OriGene Protein Over-expression Lysate for GRK6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GRK6 | | OriGene 3'-UTR Clone for GRK6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRK6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRK6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GRK6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GRK6 | | OriGene Custom Protein Services for GRK6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRK6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRK6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRK6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRK6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRK6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRK6 |
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| | Antibodies & Assays for GRK6 |
| | | | Search Tocris compounds for GRK6 |
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 | | | GRK6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK6 |
|  |  |  | | | | ThermoFisher Antibodies for GRK6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRK6 |
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