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Aliases for GRK6 Gene

Aliases for GRK6 Gene

  • G Protein-Coupled Receptor Kinase 6 2 3
  • GPRK6 3 4 6
  • EC 2.7.11.16 4 64
  • G Protein-Coupled Receptor Kinase GRK6 4
  • EC 2.7.11 64

External Ids for GRK6 Gene

Previous Symbols for GRK6 Gene

  • GPRK6

Summaries for GRK6 Gene

Entrez Gene Summary for GRK6 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRK6 Gene

GRK6 (G Protein-Coupled Receptor Kinase 6) is a Protein Coding gene. Diseases associated with GRK6 include whim syndrome. Among its related pathways are Endocytosis and CXCR4-mediated signaling events. GO annotations related to this gene include G-protein coupled receptor kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for GRK6 Gene

  • Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Gene Wiki entry for GRK6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRK6 Gene

Genomics for GRK6 Gene

Genomic Location for GRK6 Gene

Start:
177,403,204 bp from pter
End:
177,442,901 bp from pter
Size:
39,698 bases
Orientation:
Plus strand

Genomic View for GRK6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRK6 Gene

Regulatory Elements for GRK6 Gene

Proteins for GRK6 Gene

  • Protein details for GRK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43250-GRK6_HUMAN
    Recommended name:
    G protein-coupled receptor kinase 6
    Protein Accession:
    P43250
    Secondary Accessions:
    • O60541
    • Q13652

    Protein attributes for GRK6 Gene

    Size:
    576 amino acids
    Molecular mass:
    65991 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GRK6 Gene

    Alternative splice isoforms for GRK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRK6 Gene

Proteomics data for GRK6 Gene at MOPED

Post-translational modifications for GRK6 Gene

  • It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys194, Lys343, and Lys358

Domains for GRK6 Gene

UniProtKB/Swiss-Prot:

GRK6_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • P43250
  • Contains 1 protein kinase domain.:
    • P43250
  • Contains 1 RGS domain.:
    • P43250
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.:
    • P43250
genes like me logo Genes that share domains with GRK6: view

Function for GRK6 Gene

Molecular function for GRK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
UniProtKB/Swiss-Prot Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Enzyme Numbers (IUBMB) for GRK6 Gene

Gene Ontology (GO) - Molecular Function for GRK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004703 G-protein coupled receptor kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20729810
genes like me logo Genes that share ontologies with GRK6: view
genes like me logo Genes that share phenotypes with GRK6: view

Animal Models for GRK6 Gene

MGI Knock Outs for GRK6:

No data available for Transcription Factor Targeting and HOMER Transcription for GRK6 Gene

Localization for GRK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRK6 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRK6 Gene COMPARTMENTS Subcellular localization image for GRK6 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GRK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with GRK6: view

Pathways for GRK6 Gene

genes like me logo Genes that share pathways with GRK6: view

Pathways by source for GRK6 Gene

Gene Ontology (GO) - Biological Process for GRK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 8077221
GO:0016055 Wnt signaling pathway IEA --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GRK6: view

Compounds for GRK6 Gene

(11) Novoseek inferred chemical compound relationships for GRK6 Gene

Compound -log(P) Hits PubMed IDs
threonine 43.4 1
leukotriene b4 23.3 4
palmitate 19.7 1
histamine 19.3 1
isoproterenol 19 1
genes like me logo Genes that share compounds with GRK6: view

Transcripts for GRK6 Gene

Unigene Clusters for GRK6 Gene

G protein-coupled receptor kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRK6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: - -
SP6: -
SP7:
SP8:
SP9:

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GRK6 Gene

GeneLoc Exon Structure for
GRK6
ECgene alternative splicing isoforms for
GRK6

Expression for GRK6 Gene

mRNA expression in normal human tissues for GRK6 Gene

mRNA differential expression in normal tissues according to GTEx for GRK6 Gene

This gene is overexpressed in Whole Blood (16.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRK6 Gene

SOURCE GeneReport for Unigene cluster for GRK6 Gene Hs.235116

mRNA Expression by UniProt/SwissProt for GRK6 Gene

P43250-GRK6_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with GRK6: view

Orthologs for GRK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRK6 36
  • 98.02 (n)
  • 97.62 (a)
cow
(Bos Taurus)
Mammalia GRK6 36
  • 92.19 (n)
  • 96.43 (a)
GRK6 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRK6 36
  • 92.02 (n)
  • 97.79 (a)
GRK6 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grk6 36
  • 89.53 (n)
  • 95.93 (a)
Grk6 16
Grk6 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRK6 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRK6 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grk6 36
  • 89.93 (n)
  • 96.26 (a)
chicken
(Gallus gallus)
Aves GRK6 36
  • 79.9 (n)
  • 87.12 (a)
GRK6 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRK6 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7310 36
tropical clawed frog
(Silurana tropicalis)
Amphibia grk6 36
  • 72.57 (n)
  • 82.47 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.25754 36
grk6 36
  • 73.58 (n)
  • 83.9 (a)
GRK6 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gprk2 37
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grk-1 37
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9515 37
  • 62 (a)
OneToMany
Species with no ortholog for GRK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRK6 Gene

ENSEMBL:
Gene Tree for GRK6 (if available)
TreeFam:
Gene Tree for GRK6 (if available)

Paralogs for GRK6 Gene

Pseudogenes.org Pseudogenes for GRK6 Gene

genes like me logo Genes that share paralogs with GRK6: view

Variants for GRK6 Gene

Sequence variations from dbSNP and Humsavar for GRK6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs867755 -- 177,431,048(-) GCTCC(A/G)GGGCA intron-variant, upstream-variant-2KB
rs883576 -- 177,430,511(+) CCTCC(C/T)GGGCC intron-variant, upstream-variant-2KB
rs1130857 -- 177,436,518(+) CCGCC(C/G)TTCAA synonymous-codon, reference
rs2230881 -- 177,432,761(+) CCAGC(A/G)GCTGG missense, reference, utr-variant-5-prime
rs2287694 -- 177,433,292(-) GGCCT(A/G)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRK6 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv471057 CNV Loss 18288195
nsv883163 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv733n27 CNV Loss 19166990
dgv6381n71 CNV Loss 21882294
nsv883172 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv515805 CNV Loss 19592680
nsv883177 CNV Loss 21882294

Relevant External Links for GRK6 Gene

HapMap Linkage Disequilibrium report
GRK6

Disorders for GRK6 Gene

(1) MalaCards Diseases for GRK6 Gene

Search for GRK6 Gene in MalaCards »

(4) Novoseek inferred disease relationships for GRK6 Gene

Disease -log(P) Hits PubMed IDs
huntington disease 16.5 2
encephalomyelitis 16.1 1
inflammation 0 2
melanoma 0 3

Relevant External Links for GRK6

Genetic Association Database (GAD)
GRK6
Human Genome Epidemiology (HuGE) Navigator
GRK6
genes like me logo Genes that share disorders with GRK6: view

No data available for UniProtKB/Swiss-Prot for GRK6 Gene

Publications for GRK6 Gene

  1. Identification of additional members of human G-protein-coupled receptor kinase multigene family. (PMID: 8415712) Haribabu B. … Snyderman R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. (PMID: 7961702) Stoffel R.H. … Inglese J. (J. Biol. Chem. 1994) 3 4 23
  3. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. (PMID: 8366096) Benovic J.L. … Gomez J. (J. Biol. Chem. 1993) 3 4 23
  4. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. (PMID: 10506199) Premont R.T. … Lefkowitz R.J. (J. Biol. Chem. 1999) 3 4 23
  5. The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. (PMID: 16613860) Lodowski D.T. … Tesmer J.J. (J. Biol. Chem. 2006) 3 4 23

Products for GRK6 Gene

  • Addgene plasmids for GRK6

Sources for GRK6 Gene

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