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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRK6 Gene

protein-coding   GIFtS: 65
GCID: GC05P176853

G Protein-Coupled Receptor Kinase 6


(Previous symbol: GPRK6)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor Kinase 61 2
GPRK61 2 3 5
EC 2.7.11.163 8
G Protein-Coupled Receptor Kinase GRK63
EC 2.7.118

External Ids:    HGNC: 45451   Entrez Gene: 28702   Ensembl: ENSG000001980557   OMIM: 6008695   UniProtKB: P432503   

Export aliases for GRK6 gene to outside databases

Previous GC identifers: GC05P176834 GC05P176786 GC05P171774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRK6 Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily
of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled
receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRK6 Gene: 
GRK6 (G protein-coupled receptor kinase 6) is a protein-coding gene. Diseases associated with GRK6 include whim syndrome, and allergic encephalomyelitis, and among its related super-pathways are Chemokine signaling pathway and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include G-protein coupled receptor kinase activity and ATP binding. An important paralog of this gene is GRK7.

UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor
phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events
leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in
striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity).
Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in
vitro)

Gene Wiki entry for GRK6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRK6 gene promoter:
         Oct-B1   GR   oct-B3   oct-B2   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   GR-alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRK6 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

GRK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRK6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176853:  view genomic region     (about GC identifiers)

Start:
176,830,205 bp from pter      End:
176,869,902 bp from pter
Size:
39,698 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250 (See protein sequence)
Recommended Name: G protein-coupled receptor kinase 6  
Size: 576 amino acids; 65991 Da
Subcellular location: Membrane; Lipid-anchor
3 PDB 3D structures from and Proteopedia for GRK6:
2ACX (3D)        3NYN (3D)        3NYO (3D)    
Secondary accessions: O60541 Q13652
Alternative splicing: 3 isoforms:  P43250-1   P43250-2   P43250-3   

Explore the universe of human proteins at neXtProt for GRK6: NX_P43250

Explore proteomics data for GRK6 at MOPED 

Post-translational modifications:

  • UniProtKB: It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43250

  • 4/22 DME Specific Peptides for GRK6 (P43250) (see all 22)
     MNGGDLK  LNEKQIL  LQWKWLE  IPWQNEM 

    GRK6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRK6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001004105.1  NP_001004106.1  NP_002073.2  

    ENSEMBL proteins: 
     ENSP00000422873   ENSP00000421055   ENSP00000425391   ENSP00000347655   ENSP00000427581  
     ENSP00000377204   ENSP00000348230   ENSP00000433511   ENSP00000422342   ENSP00000423174  

    Human Recombinant Protein Products for GRK6: 
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    Sino Biological Recombinant Protein for GRK6
    Sino Biological Cell Lysate for GRK6 
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    Cloud-Clone Corp. Proteins for GRK6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    GRK6 for ontologies           About GeneDecksing



    GRK6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: G protein-coupled receptor kinase 6 
    G protein coupled receptor kinases
    GRK subfamily

    5/9 InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P43250

    ProtoNet protein and cluster: P43250

    3 Blocks protein domains:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain


    UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    GRK6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRK6_HUMAN, P43250
    Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor
    phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events
    leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in
    striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity).
    Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in
    vitro)
    Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate

         Enzyme Numbers (IUBMB): EC 2.7.11.161 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004703G-protein coupled receptor kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    GRK6 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GRK6:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grk6):
     behavior/neurological  immune system  no phenotypic analysis 

    GRK6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grk6tm1.1Mca for GRK6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRK6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRK6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRK6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRK6 

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    SwitchGear 3'UTR luciferase reporter plasmidGRK6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRK6 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    3Circadian entrainment
    Morphine addiction0.53
    4Thromboxane signalling through TP receptor
    Development Angiotensin signaling via beta-Arrestin0.40
    5Development Thrombopoetin signaling via JAK-STAT pathway
    Jak/Stat Pathway0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GRK6
        Development Angiotensin signaling via beta-Arrestin

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRK6
        Chemokine Signaling
    Colorectal Cancer Metastasis

    2 Cell Signaling Technology (CST) Pathways for GRK6
        Lymphocyte Signaling
    Jak/Stat Pathway

    1 GeneGo (Thomson Reuters) Pathway for GRK6
        Development Angiotensin signaling via beta-Arrestin

    4 BioSystems Pathways for GRK6
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    FSH signaling pathway
    CXCR4-mediated signaling events



    3         Kegg Pathways  (Kegg details for GRK6):
        Chemokine signaling pathway
    Endocytosis
    Morphine addiction


    GRK6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for GRK6 (P432502, 3 ENSP000003772044) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS23O950842, 3MINT-63246 I2D: score=5 
    ADRB2P075503, ENSP000003053724I2D: score=3 STRING: ENSP00000305372
    LTB4RQ157223, ENSP000003074454I2D: score=2 STRING: ENSP00000307445
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    GIT1Q9Y2X73, ENSP000003783384I2D: score=1 STRING: ENSP00000378338
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction ----
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS8077221
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0038032termination of G-protein coupled receptor signaling pathway IEA--

    GRK6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRK6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GRK6

    10/11 Novoseek inferred chemical compound relationships for GRK6 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 43.4 1 7961702 (1)
    leukotriene b4 23.3 6 14634128 (3), 12077128 (1)
    palmitate 19.7 4 9819198 (1)
    histamine 19.3 1 8913702 (1)
    isoproterenol 19 1 18034461 (1)
    tyrosine 14.7 1 16786561 (1)
    lipid 0 3 7961702 (1), 9819198 (1)
    calcium 0 7 9218466 (1), 20048153 (1), 8977246 (1), 14634128 (1) (see all 5)
    cysteine 0 2 9341194 (1), 10486211 (1)
    heparin 0 1 8077221 (1)

    Search CenterWatch for drugs/clinical trials and news about GRK6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRK6 gene (3 alternative transcripts): 
    NM_001004105.2  NM_001004106.2  NM_002082.3  

    Unigene Cluster for GRK6:

    G protein-coupled receptor kinase 6
    Hs.235116  [show with all ESTs]
    Unigene Representative Sequence: NM_002082
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502598 ENST00000506296 ENST00000511244 ENST00000355472(uc003mgq.2 uc021yit.1 uc021yiu.1)
    ENST00000507633 ENST00000393576 ENST00000355958 ENST00000528793 ENST00000512684
    ENST00000515666(uc003mgs.1) ENST00000508705

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    Additional mRNA sequence: 

    AF040751.1 AF040752.1 AK056697.1 BC009277.2 BC017272.1 L16862.1 U00686.1 

    14 DOTS entries:

    DT.92071943  DT.116496  DT.100779329  DT.100779327  DT.92071949  DT.95335419  DT.100036878  DT.120810890 
    DT.100692208  DT.120810841  DT.100666518  DT.86854742  DT.100755217  DT.92424234 

    24/274 AceView cDNA sequences (see all 274):

    BQ427844 BM823722 AW249831 BU735696 BM699704 BQ646904 AI702855 BI518779 
    BQ225134 BF445527 BU161608 BM782684 AK056697 AI798813 BE676782 BE294526 
    BI767235 BM697499 NM_001004106 BX404587 BM782732 AW197041 AW469268 BQ061148 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GRK6 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:                    -           -                                                                                               -                       -   
    SP2:                    -           -                                                                                               -                           
    SP3:                                                                                                                                -                           
    SP4:                                                                                      -                                                                     
    SP5:                                                        -                             -                                                                     

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for GRK6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCAGCAA
    GRK6 Expression
    About this image


    See GRK6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRK6

    SOURCE GeneReport for Unigene cluster: Hs.235116

    UniProtKB/Swiss-Prot: GRK6_HUMAN, P43250
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GRK6 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grk61 , 5 G protein-coupled receptor kinase 61, 5 89.53(n)1
    95.93(a)1
      13 (30.06 cM)5
    263851  NM_001038018.31  NP_001033107.11 
     554453345 
    chicken
    (Gallus gallus)
    Aves GRK61 G protein-coupled receptor kinase 6 79.9(n)
    87.12(a)
      416361  XM_414676.3  XP_414676.3 
    lizard
    (Anolis carolinensis)
    Reptilia GRK66
    --
    --
    84(a)
    59(a)
    1 ↔ 1
    possible ortholog
    2(145811420-145844517)
    GL343406.1(702937-779485)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73102 Xenopus laevis transcribed sequence with moderate similarity more 75.8(n)    BX849055.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257542 Transcribed sequence with moderate similarity to protein more 78.95(n)    AL924239.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gprk26
    G protein-coupled receptor kinase 2
    49(a)
    1 → many
    3R(27230971-27283499)
    worm
    (Caenorhabditis elegans)
    Secernentea grk-16
    G protein-coupled receptor kinase 1
    52(a)
    1 → many
    X(9991857-9999178)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBF26
    DBF206
    Ser/Thr kinase involved in transcription and stres...
    Ser/Thr kinase involved in late nuclear division, ...
    20(a)
    20(a)
    many ↔ many
    many ↔ many
    VII(668189-669907)
    XVI(747306-749000)


    ENSEMBL Gene Tree for GRK6 (if available)
    TreeFam Gene Tree for GRK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRK6 gene
    GRK72  ADRBK22  GRK12  GRK52  ADRBK12  GRK42  
    18/51 SIMAP similar genes for GRK6 using alignment to 9 protein entries:     GRK6_HUMAN (see all proteins) (see all similar genes):
    GRK5    GRK4    GRK1    GRK7    RPS6KA2    PRKCH
    BRAF    CDK7    MARK4    PKN2    PRKY    RPS6KB2
    AKT2    AKT3    NEK6    NEK9    STK11    TYK2

    GRK6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for GRK6
    PGOHUM00000248520


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/395 SNPs in GRK6 are shown (see all 395)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0405244
    A gastric adenocarcinoma sample4--see VAR_0405242 R Q mis40--------
    VAR_0405264
    A breast infiltrating ductal carcinoma sample4--see VAR_0405262 I M mis40--------
    rs1848260241,2
    --177076123(+) CTACTA/CCAGTA 3 -- us2k10--------
    rs1895970251,2
    --177076377(+) TGCCCA/GCCACC 3 -- us2k10--------
    rs1817893801,2
    --177076538(+) CACCAC/TCTCTT 3 -- us2k10--------
    rs1851883111,2
    --177076561(+) GTAAAC/TTCCTG 3 -- us2k10--------
    rs25457991,2
    C,F,A--177076578(-) agtggA/Cagcag 3 -- us2k18Minor allele frequency- C:0.34NA WA EA 368
    rs93137591,2
    C,F,H--177076647(+) ATGTTT/CCACAT 3 -- us2k110Minor allele frequency- C:0.05NS EA WA 1208
    rs1896930481,2
    C--177076680(+) GCCTCA/CTGGAC 3 -- us2k10--------
    rs1813324421,2
    --177077020(+) CTGCCA/TTCACT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRK6 (176830205 - 176869902 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for GRK6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471057CNV Loss18288195
    dgv6383n71CNV Loss21882294
    nsv883172CNV Loss21882294
    nsv883164CNV Loss21882294
    nsv883163CNV Loss21882294
    dgv6379n71CNV Loss21882294
    nsv883177CNV Loss21882294
    nsv515805CNV Loss19592680
    dgv6381n71CNV Loss21882294
    dgv733n27CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600869    OMIM disorders: --

    18 diseases for GRK6:    About MalaCards
    whim syndrome    allergic encephalomyelitis    encephalomyelitis    huntington's disease
    skin cancer    schizoaffective disorder    anorexia nervosa    hyperparathyroidism
    multiple myeloma    kidney disease    myeloma    parkinson's disease
    neuroblastoma    atherosclerosis    colorectal cancer    schizophrenia
    endotheliitis    neuronitis


    GRK6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for GRK6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 16.5 2 8415712 (2)
    encephalomyelitis 16.1 1 12667650 (1)
    inflammation 0 2 14634128 (2)
    melanoma 0 3 15650023 (2), 17130136 (1)

    Genetic Association Database (GAD): GRK6
    Human Genome Epidemiology (HuGE) Navigator: GRK6 (5 documents)

    Export disorders for GRK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRK6 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with GRK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of additional members of human G-protein-coupled receptor kinase multigene family. (PubMed id 8415712)1, 2, 3, 9 Haribabu B. and Snyderman R. (1993)
    2. The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. (PubMed id 16613860)1, 2, 9 Lodowski D.T.... Tesmer J.J. (2006)
    3. Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. (PubMed id 7961702)1, 2, 9 Stoffel R.H.... Inglese J. (1994)
    4. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. (PubMed id 8366096)1, 2, 9 Benovic J.L. and Gomez J. (1993)
    5. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. (PubMed id 10506199)1, 2, 9 Premont R.T....Lefkowitz R.J. (1999)
    6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    7. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. (PubMed id 19801552)1, 2 Chen M....Chen W. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2870 HGNC: 4545 AceView: GRK6 Ensembl:ENSG00000198055 euGenes: HUgn2870
    ECgene: GRK6 Kegg: 2870 H-InvDB: GRK6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GRK6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRK6 gene:
    Search GeneIP for patents involving GRK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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