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Aliases for GRK6 Gene

Aliases for GRK6 Gene

  • G Protein-Coupled Receptor Kinase 6 2 3 5
  • EC 2.7.11.16 4 61
  • GPRK6 3 4
  • G Protein-Coupled Receptor Kinase GRK6 4
  • EC 2.7.11 61

External Ids for GRK6 Gene

Previous HGNC Symbols for GRK6 Gene

  • GPRK6

Previous GeneCards Identifiers for GRK6 Gene

  • GC05P176834
  • GC05P176786
  • GC05P176853
  • GC05P171774

Summaries for GRK6 Gene

Entrez Gene Summary for GRK6 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRK6 Gene

GRK6 (G Protein-Coupled Receptor Kinase 6) is a Protein Coding gene. Diseases associated with GRK6 include Whim Syndrome. Among its related pathways are GABAergic synapse and CCR5 Pathway in Macrophages. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GRK5.

UniProtKB/Swiss-Prot for GRK6 Gene

  • Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Gene Wiki entry for GRK6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRK6 Gene

Genomics for GRK6 Gene

Regulatory Elements for GRK6 Gene

Enhancers for GRK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G177425 1.8 FANTOM5 ENCODE dbSUPER 29.9 +26.2 26168 8.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 GRK6 DOK3 FAF2 UIMC1 PFN3 DBN1 SLC34A1 LOC202181 MXD3 B4GALT7
GH05G177360 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -40.8 -40775 3.3 HDGF PKNOX1 ARNT SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B ZNF143 FOS RGS14 RAB24 MXD3 PFN3 GRK6 F12 PRELID1 DBN1 DOK3 SLC34A1
GH05G177453 1.7 Ensembl ENCODE dbSUPER 12 +53.7 53661 6.9 HDGF PKNOX1 MLX ARNT CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF346 ZNF346-IT1 SLC34A1 F12 GRK6 PFN3 MXD3 LOC202181 B4GALT7 PRR7
GH05G177443 1.6 Ensembl ENCODE dbSUPER 12.5 +43.2 43160 6.1 HNRNPUL1 HDGF FOXA2 PKNOX1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 F12 GRK6 PFN3 SLC34A1 DBN1 MXD3 FAF2 RGS14 LMAN2 PRR7
GH05G177368 1.3 ENCODE dbSUPER 12.5 -32.5 -32502 5.1 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 RGS14 PFN3 GRK6 F12 MXD3 PRELID1 RAB24 SLC34A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRK6 on UCSC Golden Path with GeneCards custom track

Promoters for GRK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191333 996 801 AGO1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 KLF13 ZNF263

Genomic Location for GRK6 Gene

Chromosome:
5
Start:
177,403,204 bp from pter
End:
177,442,901 bp from pter
Size:
39,698 bases
Orientation:
Plus strand

Genomic View for GRK6 Gene

Genes around GRK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRK6 Gene

Proteins for GRK6 Gene

  • Protein details for GRK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43250-GRK6_HUMAN
    Recommended name:
    G protein-coupled receptor kinase 6
    Protein Accession:
    P43250
    Secondary Accessions:
    • O60541
    • Q13652

    Protein attributes for GRK6 Gene

    Size:
    576 amino acids
    Molecular mass:
    65991 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GRK6 Gene

    Alternative splice isoforms for GRK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRK6 Gene

Selected DME Specific Peptides for GRK6 Gene

P43250:
  • ENIVANTV
  • KGKSKKW
  • QPIGRLLFR
  • GRVGTVGYMAPE
  • MNGGDLK
  • GHIRISDLGL
  • IPWQNEM
  • KDVLDIEQFSTVKGV
  • FLQWKWLERQPVTKNTFR
  • YRVLGKGGFGEVCACQVRA
  • PDPQAIYC
  • RDLKPEN
  • LNEKQIL
  • LQWKWLE
  • YFNRFLQWKWLER
  • KKKIKRE
  • LKAREGG
  • YETKDALCLVLT
  • PPKKGLLQRLF
  • KKRIKKRKGE
  • RISDLGLA
  • KPENILLD

Post-translational modifications for GRK6 Gene

  • It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
  • Ubiquitination at posLast=343343 and isoforms=2, 3358
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for GRK6 (GRK6)
  • Abcam antibodies for GRK6

Domains & Families for GRK6 Gene

Suggested Antigen Peptide Sequences for GRK6 Gene

Graphical View of Domain Structure for InterPro Entry

P43250

UniProtKB/Swiss-Prot:

GRK6_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
genes like me logo Genes that share domains with GRK6: view

Function for GRK6 Gene

Molecular function for GRK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
UniProtKB/Swiss-Prot Function:
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Enzyme Numbers (IUBMB) for GRK6 Gene

Gene Ontology (GO) - Molecular Function for GRK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004703 G-protein coupled receptor kinase activity IEA --
GO:0005515 protein binding IPI 20729810
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GRK6: view
genes like me logo Genes that share phenotypes with GRK6: view

Animal Models for GRK6 Gene

MGI Knock Outs for GRK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRK6

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRK6 Gene

Localization for GRK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRK6 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRK6 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
cytosol 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with GRK6: view

Pathways & Interactions for GRK6 Gene

genes like me logo Genes that share pathways with GRK6: view

Gene Ontology (GO) - Biological Process for GRK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS 8077221
GO:0016055 Wnt signaling pathway IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with GRK6: view

No data available for SIGNOR curated interactions for GRK6 Gene

Drugs & Compounds for GRK6 Gene

(9) Drugs for GRK6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GRK6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRK6: view

Transcripts for GRK6 Gene

Unigene Clusters for GRK6 Gene

G protein-coupled receptor kinase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRK6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: - -
SP6: -
SP7:
SP8:
SP9:

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GRK6 Gene

GeneLoc Exon Structure for
GRK6
ECgene alternative splicing isoforms for
GRK6

Expression for GRK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRK6 Gene

mRNA differential expression in normal tissues according to GTEx for GRK6 Gene

This gene is overexpressed in Whole Blood (x16.2).

Protein differential expression in normal tissues from HIPED for GRK6 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.9) and Peripheral blood mononuclear cells (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRK6 Gene



Protein tissue co-expression partners for GRK6 Gene

NURSA nuclear receptor signaling pathways regulating expression of GRK6 Gene:

GRK6

SOURCE GeneReport for Unigene cluster for GRK6 Gene:

Hs.235116

mRNA Expression by UniProt/SwissProt for GRK6 Gene:

P43250-GRK6_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for GRK6 Gene

  • Nervous system(2.9)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with GRK6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRK6 Gene

Orthologs for GRK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRK6 34
  • 98.02 (n)
cow
(Bos Taurus)
Mammalia GRK6 34 35
  • 92.19 (n)
dog
(Canis familiaris)
Mammalia GRK6 34 35
  • 92.02 (n)
rat
(Rattus norvegicus)
Mammalia Grk6 34
  • 89.93 (n)
mouse
(Mus musculus)
Mammalia Grk6 34 16 35
  • 89.53 (n)
oppossum
(Monodelphis domestica)
Mammalia GRK6 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRK6 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRK6 34 35
  • 79.9 (n)
lizard
(Anolis carolinensis)
Reptilia GRK6 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grk6 34
  • 72.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7310 34
zebrafish
(Danio rerio)
Actinopterygii GRK6 35
  • 82 (a)
OneToOne
grk6 34
  • 73.58 (n)
Dr.25754 34
fruit fly
(Drosophila melanogaster)
Insecta Gprk2 35
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grk-1 35
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9515 35
  • 62 (a)
OneToMany
Species where no ortholog for GRK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRK6 Gene

ENSEMBL:
Gene Tree for GRK6 (if available)
TreeFam:
Gene Tree for GRK6 (if available)

Paralogs for GRK6 Gene

Variants for GRK6 Gene

Sequence variations from dbSNP and Humsavar for GRK6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs141014084 A gastric adenocarcinoma sample 177,430,911(+) ATGGC(A/G)GCAGA upstream-variant-2KB, reference, missense, utr-variant-5-prime
VAR_040526 A breast infiltrating ductal carcinoma sample
rs1000004477 -- 177,426,489(+) AAGAG(-/GTGAC)GTGAT upstream-variant-2KB
rs1000268936 -- 177,438,403(+) AAGAT(A/G)GCAGA intron-variant, nc-transcript-variant
rs1000375801 -- 177,437,511(+) TGAGC(A/G)TCTCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for GRK6 Gene

Variant ID Type Subtype PubMed ID
dgv10184n54 CNV loss 21841781
dgv733n27 CNV loss 19166990
nsv1161311 CNV duplication 26073780
nsv1161313 CNV duplication 26073780
nsv471057 CNV loss 18288195
nsv515805 CNV loss 19592680
nsv600364 CNV loss 21841781

Variation tolerance for GRK6 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRK6 Gene

Disorders for GRK6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRK6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
whim syndrome
  • warts, hypogammaglobulinemia, infections, and myelokathexis
- elite association - COSMIC cancer census association via MalaCards
Search GRK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRK6

Genetic Association Database (GAD)
GRK6
Human Genome Epidemiology (HuGE) Navigator
GRK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRK6
genes like me logo Genes that share disorders with GRK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRK6 Gene

Publications for GRK6 Gene

  1. Identification of additional members of human G-protein-coupled receptor kinase multigene family. (PMID: 8415712) Haribabu B. … Snyderman R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 22 64
  2. The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. (PMID: 16613860) Lodowski D.T. … Tesmer J.J. (J. Biol. Chem. 2006) 3 4 22 64
  3. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. (PMID: 10506199) Premont R.T. … Lefkowitz R.J. (J. Biol. Chem. 1999) 3 4 22 64
  4. Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. (PMID: 7961702) Stoffel R.H. … Inglese J. (J. Biol. Chem. 1994) 3 4 22 64
  5. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. (PMID: 8366096) Benovic J.L. … Gomez J. (J. Biol. Chem. 1993) 3 4 22 64

Products for GRK6 Gene

  • Addgene plasmids for GRK6

Sources for GRK6 Gene

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