Aliases for GRK4 Gene
External Ids for GRK4 Gene
Previous HGNC Symbols for GRK4 Gene
Previous GeneCards Identifiers for GRK4 Gene
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for GRK4 Gene
GRK4 (G Protein-Coupled Receptor Kinase 4) is a Protein Coding gene. Diseases associated with GRK4 include Familial Hypertension and Aortic Coarctation. Among its related pathways are Metabolism of fat-soluble vitamins and CCR5 Pathway in Macrophages. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GRK5.
UniProtKB/Swiss-Prot for GRK4 Gene
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.