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Aliases for GRK4 Gene

Aliases for GRK4 Gene

  • G Protein-Coupled Receptor Kinase 4 2 3
  • EC 2.7.11.16 4 63
  • GPRK2L 3 4
  • GPRK4 3 4
  • ITI1 3 4
  • G Protein-Coupled Receptor Kinase 2-Like (Drosophila) 2
  • G Protein-Coupled Receptor Kinase GRK4 4
  • EC 2.7.11 63
  • GRK4a 3
  • IT11 3

External Ids for GRK4 Gene

Previous HGNC Symbols for GRK4 Gene

  • GPRK2L

Previous GeneCards Identifiers for GRK4 Gene

  • GC04P002997
  • GC04P002996
  • GC04P003002

Summaries for GRK4 Gene

Entrez Gene Summary for GRK4 Gene

  • This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for GRK4 Gene

GRK4 (G Protein-Coupled Receptor Kinase 4) is a Protein Coding gene. Diseases associated with GRK4 include aortic coarctation and hypertension, essential. Among its related pathways are Signaling by GPCR and Endocytosis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for GRK4 Gene

  • Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

Gene Wiki entry for GRK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRK4 Gene

Genomics for GRK4 Gene

Regulatory Elements for GRK4 Gene

Genomic Location for GRK4 Gene

Chromosome:
4
Start:
2,963,505 bp from pter
End:
3,040,752 bp from pter
Size:
77,248 bases
Orientation:
Plus strand

Genomic View for GRK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRK4 Gene

Proteins for GRK4 Gene

  • Protein details for GRK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32298-GRK4_HUMAN
    Recommended name:
    G protein-coupled receptor kinase 4
    Protein Accession:
    P32298
    Secondary Accessions:
    • O00641
    • O00642
    • Q13293
    • Q13294
    • Q13295
    • Q14453
    • Q14725
    • Q15313
    • Q15314
    • Q15315
    • Q15316
    • Q17RH6
    • Q53EQ8

    Protein attributes for GRK4 Gene

    Size:
    578 amino acids
    Molecular mass:
    66583 Da
    Quaternary structure:
    • Interacts with DRD3.

    Three dimensional structures from OCA and Proteopedia for GRK4 Gene

    Alternative splice isoforms for GRK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRK4 Gene

Proteomics data for GRK4 Gene at MOPED

Post-translational modifications for GRK4 Gene

Other Protein References for GRK4 Gene

Antibody Products

Domains & Families for GRK4 Gene

Suggested Antigen Peptide Sequences for GRK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32298

UniProtKB/Swiss-Prot:

GRK4_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 RGS domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
genes like me logo Genes that share domains with GRK4: view

Function for GRK4 Gene

Molecular function for GRK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by heparin.
UniProtKB/Swiss-Prot Function:
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

Enzyme Numbers (IUBMB) for GRK4 Gene

Gene Ontology (GO) - Molecular Function for GRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004703 G-protein coupled receptor kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0050254 rhodopsin kinase activity IEA --
genes like me logo Genes that share ontologies with GRK4: view
genes like me logo Genes that share phenotypes with GRK4: view

Animal Models for GRK4 Gene

MGI Knock Outs for GRK4:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRK4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for GRK4 Gene

Localization for GRK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRK4 Gene

Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRK4 Gene COMPARTMENTS Subcellular localization image for GRK4 gene
Compartment Confidence
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005938 cell cortex IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
GO:0097381 photoreceptor disc membrane TAS --
genes like me logo Genes that share ontologies with GRK4: view

Pathways & Interactions for GRK4 Gene

genes like me logo Genes that share pathways with GRK4: view

Gene Ontology (GO) - Biological Process for GRK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway --
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction --
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with GRK4: view

No data available for SIGNOR curated interactions for GRK4 Gene

Drugs & Compounds for GRK4 Gene

(7) Drugs for GRK4 Gene - From: NovoSeek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 98
Metoprolol Approved, Investigational Pharma Antagonist 186
Verapamil Approved Pharma Inhibition, Inhibitor 112
Baclofen Approved Pharma 90
Dopamine Approved Pharma Full agonist, Agonist 2814

(2) Additional Compounds for GRK4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glutamate
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with GRK4: view

Transcripts for GRK4 Gene

Unigene Clusters for GRK4 Gene

G protein-coupled receptor kinase 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRK4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7:
SP8:

Relevant External Links for GRK4 Gene

GeneLoc Exon Structure for
GRK4
ECgene alternative splicing isoforms for
GRK4

Expression for GRK4 Gene

mRNA expression in normal human tissues for GRK4 Gene

mRNA differential expression in normal tissues according to GTEx for GRK4 Gene

This gene is overexpressed in Testis (x9.0).

Protein differential expression in normal tissues from HIPED for GRK4 Gene

This gene is overexpressed in CD8 Tcells (40.5) and NK cells (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRK4 Gene



SOURCE GeneReport for Unigene cluster for GRK4 Gene Hs.32959

mRNA Expression by UniProt/SwissProt for GRK4 Gene

P32298-GRK4_HUMAN
Tissue specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.
genes like me logo Genes that share expression patterns with GRK4: view

Protein tissue co-expression partners for GRK4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GRK4 Gene

Orthologs for GRK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRK4 35
  • 77.72 (n)
  • 77.66 (a)
GRK4 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRK4 35
  • 83.65 (n)
  • 79.41 (a)
GRK4 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grk4 35
  • 80.94 (n)
  • 75.7 (a)
Grk4 16
Grk4 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRK4 35
  • 99.37 (n)
  • 99.13 (a)
GRK4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grk4 35
  • 81.07 (n)
  • 75.96 (a)
oppossum
(Monodelphis domestica)
Mammalia GRK4 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRK4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRK4 35
  • 75.28 (n)
  • 75.75 (a)
GRK4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia grk4 35
  • 71.8 (n)
  • 76.71 (a)
zebrafish
(Danio rerio)
Actinopterygii grk4 35
  • 68.73 (n)
  • 75.62 (a)
grk4 36
  • 75 (a)
OneToMany
grk4 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Gprk2 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grk-1 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9515 36
  • 58 (a)
OneToMany
Species with no ortholog for GRK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRK4 Gene

ENSEMBL:
Gene Tree for GRK4 (if available)
TreeFam:
Gene Tree for GRK4 (if available)

Paralogs for GRK4 Gene

genes like me logo Genes that share paralogs with GRK4: view

Variants for GRK4 Gene

Sequence variations from dbSNP and Humsavar for GRK4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_007806 -
VAR_024573 -
VAR_024574 -
VAR_024575 -, -
VAR_040516 -

Structural Variations from Database of Genomic Variants (DGV) for GRK4 Gene

Variant ID Type Subtype PubMed ID
nsv461163 CNV Gain 19166990
nsv878453 CNV Loss 21882294
esv2662217 CNV Deletion 23128226
esv2726868 CNV Deletion 23290073
esv2661728 CNV Deletion 23128226

Variation tolerance for GRK4 Gene

Residual Variation Intolerance Score: 90.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.91; 97.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRK4 Gene

HapMap Linkage Disequilibrium report
GRK4
Human Gene Mutation Database (HGMD)
GRK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRK4 Gene

Disorders for GRK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRK4 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
aortic coarctation
  • coarctation of the aorta
hypertension, essential
  • hypertension, essential 3
- elite association
Search GRK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRK4

Genetic Association Database (GAD)
GRK4
Human Genome Epidemiology (HuGE) Navigator
GRK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRK4
genes like me logo Genes that share disorders with GRK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRK4 Gene

Publications for GRK4 Gene

  1. G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. (PMID: 19119263) Bhatnagar V. … Lipkowitz M.S. (Am. J. Hypertens. 2009) 23 67
  2. G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. (PMID: 19520868) Villar V.A.M. … Jose P.A. (J. Biol. Chem. 2009) 23 67
  3. Caveolin-1 and dopamine-mediated internalization of NaKATPase in human renal proximal tubule cells. (PMID: 19752292) Gildea J.J. … Felder R.A. (Hypertension 2009) 23 67
  4. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. (PMID: 18413491) Staessen J.A. … Brand E. (Hypertension 2008) 23 67
  5. Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis. (PMID: 18767025) Matsubayashi J. … Mukai K. (J. Pathol. 2008) 23 67

Products for GRK4 Gene

Sources for GRK4 Gene

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