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GRK4 Gene

protein-coding   GIFtS: 63
GCID: GC04P002967

G Protein-Coupled Receptor Kinase 4

(Previous name: G protein-coupled receptor kinase 2-like (Drosophila))
(Previous symbol: GPRK2L)
  See GRK4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor Kinase 41 2     G Protein-Coupled Receptor Kinase 2-Like (Drosophila)1
GPRK2L1 2 3 5     GRK4a2
GPRK42 3 5     IT112
ITI12 3     G Protein-Coupled Receptor Kinase GRK43
EC 2.7.11.163 8     EC 2.7.118

External Ids:    HGNC: 45431   Entrez Gene: 28682   Ensembl: ENSG000001253887   OMIM: 1370265   UniProtKB: P322983   

Export aliases for GRK4 gene to outside databases

Previous GC identifers: GC04P002997 GC04P002996 GC04P003002


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRK4 Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily
of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled
receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.
Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov
2013)

GeneCards Summary for GRK4 Gene:
GRK4 (G protein-coupled receptor kinase 4) is a protein-coding gene. Diseases associated with GRK4 include aortic coarctation, and hypertension. GO annotations related to this gene include G-protein coupled receptor kinase activity and rhodopsin kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can
phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not
phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3.
Phosphorylates ADRB2

Gene Wiki entry for GRK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRK4 gene promoter:
         COUP-TF1   Nkx3-1   Nkx3-1 v4   COUP   Nkx3-1 v1   Nkx2-5   HNF-4alpha1   Nkx3-1 v2   COUP-TF   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRK4 promoter sequence
   Search Chromatin IP Primers for GRK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

GRK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRK4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P002967:  view genomic region     (about GC identifiers)

Start:
2,965,335 bp from pter      End:
3,042,474 bp from pter
Size:
77,140 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298 (See protein sequence)
Recommended Name: G protein-coupled receptor kinase 4  
Size: 578 amino acids; 66583 Da
Subunit: Interacts with DRD3
Secondary accessions: O00641 O00642 Q13293 Q13294 Q13295 Q14453 Q14725 Q15313 Q15314 Q15315
Q15316 Q17RH6 Q53EQ8
Alternative splicing: 4 isoforms:  P32298-1   P32298-2   P32298-3   P32298-4   

Explore the universe of human proteins at neXtProt for GRK4: NX_P32298

Explore proteomics data for GRK4 at MOPED

Post-translational modifications: 

  • Palmitoylated1
  • Ubiquitination2 at Lys195
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for GRK4 (P32298) (see all 14)
     MNGGDLK  LQWKWLE  TIMNGGD  IPWQNEM 


    See GRK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001004056.1  NP_001004057.1  NP_005298.2  NP_892027.2  

    ENSEMBL proteins: 
     ENSP00000381128   ENSP00000421650   ENSP00000381129   ENSP00000264764   ENSP00000427445  
     ENSP00000392297  

    GRK4 Human Recombinant Protein Products:

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    antibodies-online peptides for GRK4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: G protein-coupled receptor kinase 4
    G protein coupled receptor kinases
    GRK subfamily

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P32298

    ProtoNet protein and cluster: P32298

    3 Blocks protein domains:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain


    UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    Find genes that share domains with GRK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRK4_HUMAN, P32298
    Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can
    phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not
    phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3.
    Phosphorylates ADRB2
    Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
    Enzyme regulation: Inhibited by heparin

         Enzyme Numbers (IUBMB): EC 2.7.11.161 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004703G-protein coupled receptor kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with GRK4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for GRK4:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Grk4):
     normal 

    Find genes that share phenotypes with GRK4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Grk4tm1Rjl for GRK4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRK4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRK4_HUMAN, P32298: Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the
    cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear
    area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid
    rafts of renal proximal tubule cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005938cell cortex IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with GRK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRK4 About    
    See pathways by source

    SuperPathContained pathways About
    1Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    2Circadian entrainment
    Morphine addiction0.53
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    4Endocytosis
    Endocytosis


    Find genes that share SuperPaths with GRK4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRK4
        Chemokine Signaling
    Visual Cycle in Retinal Rods
    Colorectal Cancer Metastasis

    2 BioSystems Pathways for GRK4
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell



    3 Kegg Pathways  (Kegg details for GRK4):
        Chemokine signaling pathway
    Endocytosis
    Morphine addiction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GRK4
    Interactions:

        Search GeneGlobe Interaction Network for GRK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRK4 (P322983 ENSP000003811294) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    FSHRP239453, ENSP000003847084I2D: score=1 STRING: ENSP00000384708
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002029desensitization of G-protein coupled receptor protein signaling pathway ----
    GO:0002031G-protein coupled receptor internalization IEA--
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS1338872

    Find genes that share ontologies with GRK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GRK4

    6 Novoseek inferred chemical compound relationships for GRK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 56.4 13 16439609 (2), 15133310 (1), 16636192 (1), 16441255 (1) (see all 8)
    dopamine 50.8 9 16439609 (1), 16461192 (1), 16441255 (1), 19520868 (1)
    baclofen 32 2 17013811 (1)
    serine 21.6 1 15521360 (1)
    glutamate 10.1 6 12519791 (2), 11099476 (2), 11431139 (1)
    cysteine 0 1 9341194 (1)

    1 PharmGKB related drug/compound annotation for GRK4 gene    About this table
    Drug/compound PharmGKB Annotation
    metoprololCA  



    Find genes that share compounds with GRK4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRK4 gene (4 alternative transcripts): 
    NM_001004056.1  NM_001004057.1  NM_005307.2  NM_182982.2  

    Unigene Cluster for GRK4:

    G protein-coupled receptor kinase 4
    Hs.32959  [show with all ESTs]
    Unigene Representative Sequence: AK292390
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398051(uc003ggq.1) ENST00000503518(uc003ggm.3) ENST00000398052(uc003ggn.1 uc003ggo.1 uc003ggp.1)
    ENST00000345167 ENST00000504933 ENST00000507230 ENST00000505271 ENST00000509545
    ENST00000511827 ENST00000504308 ENST00000442472
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    Additional mRNA sequence: 

    AK055721.1 AK223581.1 AK292390.1 AK293569.1 BC027597.1 BC039732.1 BC063678.1 BC117320.1 
    U33054.1 U33055.1 U33056.1 X75897.1 X97879.1 X97880.1 X97881.1 X98118.1 

    10 DOTS entries:

    DT.101981328  DT.40220101  DT.413731  DT.86853791  DT.101979674  DT.413730  DT.40111448  DT.413729 
    DT.75172625  DT.97821341 

    Selected AceView cDNA sequences (see all 56):

    BC039732 X97880 NM_001004057 X75897 X97881 BC063678 BM928228 NM_182982 
    BX279959 BM725978 AA412224 AW269179 BE502168 AI243951 NM_001004056 CK725053 
    W23870 AA905915 AA938959 NM_005307 U33054 AI150462 AI798928 AK055721 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for GRK4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                            -                 -                                                                 -               
    SP2:                          -     -           -                 -                                                                 -               
    SP3:                                            -                 -                                                           -     -               
    SP4:                          -     -           -                 -                                                           -     -               
    SP5:                          -     -     -     -                 -                                                                                 


    ECgene alternative splicing isoforms for GRK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGGGAGT
    GRK4 Expression
    About this image

    GRK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32959

    UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
    Tissue specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed
    in myometrium

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRK4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grk41 , 5 G protein-coupled receptor kinase 41, 5 80.94(n)1
    75.7(a)1
      5 (17.91 cM)5
    147721  NM_019497.21  NP_062370.21 
     346603795 
    chicken
    (Gallus gallus)
    Aves GRK41 G protein-coupled receptor kinase 4 75.28(n)
    75.75(a)
      422879  NM_001006459.1  NP_001006459.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    many ↔ many
    GL343406.1(702937-779485)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grk41 G protein-coupled receptor kinase 4 71.8(n)
    76.71(a)
      448587  NM_001006112.1  NP_001006112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii grk41 G protein-coupled receptor kinase 4 68.73(n)
    75.62(a)
      560761  NM_001079986.1  NP_001073455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gprk26
    G protein-coupled receptor kinase 2
    47(a)
    1 → many
    3R(27230971-27283499)
    worm
    (Caenorhabditis elegans)
    Secernentea grk-16
    Protein GRK-1 (grk-1) mRNA, complete cds
    49(a)
    1 → many
    X(9991326-9999178) WBGene00001708


    ENSEMBL Gene Tree for GRK4 (if available)
    TreeFam Gene Tree for GRK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRK4 gene
    AKT12  GRK72  RPS6KB12  GRK12  SGK32  GRK62  C8orf44-SGK32  SGK22  
    ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  
    Selected SIMAP similar genes for GRK4 using alignment to 3 protein entries:     GRK4_HUMAN (see all proteins) (see all similar genes):
    GRK5    GRK6    GRK1    GRK7    MARK4    PRKY
    RPS6KA2    AKT3    KIN27    RPS6KA3    SGK2    PRKACB
    PkB-like 1    ADRBK2    AKT1    AKT2    NEK6    ADRBK1

    Find genes that share paralogs with GRK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRK4 (see all 1788)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792522761,2
    C--2967133(+) GCCACA/GGTAGT 3 -- int10--------
    rs1864169011,2
    --2967162(+) CTTACA/GGAATT 3 -- int10--------
    rs1892156321,2
    C--2967163(+) TTACGA/GAATTG 3 -- int10--------
    rs1815330571,2
    --2967172(+) TGCTGA/CTTTCC 3 -- int10--------
    rs731894801,2
    C--2967210(+) CTGCTC/TGGACT 3 -- int13Minor allele frequency- T:0.06NA EA 242
    rs1866409671,2
    --2967211(+) TGCTCA/GGACTG 3 -- int10--------
    rs1914840041,2
    --2967262(+) CAGCCA/GGCGAT 3 -- int10--------
    rs1461118561,2
    --2967293(+) GGAGCC/TGAAGG 3 -- int10--------
    rs10560941,2
    C,F,O,A,H--2967598(+) TCCCTG/CACTGT 3 -- int125Minor allele frequency- C:0.31MN NA NS EA WA CSA 1478
    rs1168043911,2
    --2967726(+) CCAAGC/TCGCCT 3 -- int10--------

    HapMap Linkage Disequilibrium report for GRK4 (2965335 - 3042474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GRK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662217CNV Deletion23128226
    esv2661728CNV Deletion23128226
    esv2726868CNV Deletion23290073
    nsv878453CNV Loss21882294
    nsv461163CNV Gain19166990

    Human Gene Mutation Database (HGMD): GRK4
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GRK4
    DNA2.0 Custom Variant and Variant Library Synthesis for GRK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137026    OMIM disorders: --

    3 diseases for GRK4:    
    About MalaCards
    aortic coarctation    hypertension    essential hypertension


    Find genes that share disorders with GRK4           About GenesLikeMe

    2 Novoseek inferred disease relationships for GRK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genetic hypertension 79.4 2 16636192 (2)
    essential hypertension 61.6 17 17044852 (2), 15097232 (1), 11904438 (1), 16339846 (1) (see all 9)

    Genetic Association Database (GAD): GRK4
    Human Genome Epidemiology (HuGE) Navigator: GRK4 (19 documents)

    Export disorders for GRK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRK4 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with GRK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel G protein-coupled receptor kinase gene cloned from 4p16.3. (PubMed id 1338872)1, 2, 3 Ambrose C.... McDonald M.E. (Hum. Mol. Genet. 1992)
    2. G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. (PubMed id 19520868)1, 2, 9 Villar V.A.M....Jose P.A. (J. Biol. Chem. 2009)
    3. Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. (PubMed id 8626439)1, 2, 9 Premont R.T.... Lefkowitz R.J. (J. Biol. Chem. 1996)
    4. G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. (PubMed id 9092566)1, 2, 9 Sallese M.... de Blasi A. (J. Biol. Chem. 1997)
    5. The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins. (PubMed id 16461192)1, 4, 9 Zhu H....Dong Y. (Am. J. Hypertens. 2006)
    6. Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese. (PubMed id 17044852)1, 4, 9 Wang Y....Gu D. (Ann. Hum. Genet. 2006)
    7. Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. (PubMed id 8135832)1, 2, 9 Sallese M.... de Blasi A. (Biochem. Biophys. Res. Commun. 1994)
    8. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. (PubMed id 18413491)1, 4, 9 Staessen J.A....Brand E. (Hypertension 2008)
    9. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. (PubMed id 12446468)1, 4, 9 Bengra C....Felder R.A. (Clin. Chem. 2002)
    10. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. (PubMed id 15097232)1, 4, 9 Speirs H.J....Morris B.J. (J. Hypertens. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2868 HGNC: 4543 AceView: GRK4 Ensembl:ENSG00000125388 euGenes: HUgn2868
    ECgene: GRK4 Kegg: 2868 H-InvDB: GRK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRK4 gene:
    Search GeneIP for patents involving GRK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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