GRK4 Gene
protein-coding GIFtS: 61
GCID: GC04P002967
|
|
G protein-coupled receptor kinase 4(Previous name: G protein-coupled receptor kinase 2-like (Drosophila) )
(Previous symbol: GPRK2L)
| |
Aliases
for GRK4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| G Protein-Coupled Receptor Kinase 41 2 | | G Protein-Coupled Receptor Kinase 2-Like (Drosophila)1 | | GPRK2L1 2 3 5 | | GRK4a2 | | GPRK41 2 3 5 | | IT112 | | ITI12 3 | | G Protein-Coupled Receptor Kinase GRK43 | | EC 2.7.11.163 8 | | EC 2.7.118 |
Export aliases for GRK4 gene to outside databasesPrevious GC identifers: GC04P002997 GC04P002996 GC04P003002 |
Summaries
for GRK4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRK4:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily ofthe Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thusinitiating its deactivation. This gene has been linked to both genetic and acquired hypertension. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylaterhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and donot interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2
Gene Wiki entry for GRK4
|
Genomic Views
for GRK4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRK4 gene promoter:
COUP-TF1 Nkx3-1 Nkx3-1 v4 COUP Nkx3-1 v1 Nkx2-5 HNF-4alpha1 Nkx3-1 v2 COUP-TF Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRK4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRK4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3GRK4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P002967: view genomic region
(about GC identifiers)
Start:
|
2,965,335 bp from pter |
End:
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3,042,474 bp from pter |
Size:
|
77,140 bases |
Orientation:
|
plus strand |
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Proteins
for GRK4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298 (See
protein sequence)Recommended Name: G protein-coupled receptor kinase 4 Size: 578 amino acids; 66583 Da
Subunit: Interacts with DRD3
Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasmunder basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, whereco-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renalproximal tubule cells
Secondary accessions: O00641 O00642 Q13293 Q13294 Q13295 Q14453 Q14725 Q15313 Q15314 Q15315 Q15316Q17RH6 Q53EQ8Alternative splicing: 4 isoforms: P32298-1 P32298-2 P32298-3 P32298-4 Explore the universe of human proteins at neXtProt for GRK4: NX_P32298
Post-translational modifications:
Palmitoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P32298
4/14 DME Specific Peptides for GRK4 (P32298) (see all 14)
GRK4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001004056.1 NP_001004057.1 NP_892027.2
ENSEMBL proteins: ENSP00000381128 ENSP00000421650 ENSP00000381129 ENSP00000264764 ENSP00000427445 ENSP00000392297
Human Recombinant Protein Products for GRK4:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
GRK4 for ontologies About GeneDecksing
GRK4 Antibody Products:
Assay Products for GRK4: |
Protein
Domains /
Families
for GRK4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRK4 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry P32298ProtoNet protein and cluster: P32298 3 Blocks protein families: IPB000239 GPCR kinase signature IPB000342 Regulator of G-protein signalling (RGS) protein signature IPB000961 Protein kinase C-terminal domain
UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 RGS domain |
Function
for GRK4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: GRK4_HUMAN, P32298Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylaterhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and donot interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphateEnzyme regulation: Inhibited by heparin Enzyme Numbers (IUBMB): EC 2.7.11.161 2 EC 2.7.112
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004703 | G-protein coupled receptor kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0050254 | rhodopsin kinase activity |
IEA | -- |
GRK4 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for GRK4:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Grk4):
GRK4 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Grk4tm1Rjl for GRK4
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRK4 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRK4 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): GRK4 (NM_182982) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRK4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRK4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK4 |
|
Pathways & Interactions
for GRK4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Calcium Regulation in the Cardiac Cell | | | 2 | Endocytosis | | | 3 | Chemokine Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for GRK4
2 
Kegg Pathways (Kegg details for GRK4):
GRK4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRK4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/28 Interacting proteins for GRK4 (P322983 ENSP000003811294) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002029 | desensitization of G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0002031 | G-protein coupled receptor internalization |
IEA | -- | | GO:0006468 | protein phosphorylation |
-- | -- | | GO:0007165 | signal transduction |
IEA | -- | | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
TAS | 1338872 |
GRK4 for ontologies About GeneDecksing
|
Drugs & Compounds
for GRK4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GRK4 for compounds About GeneDecksing
 Browse Tocris compounds for GRK4
6 Novoseek chemical compound relationships for GRK4 gene About this table
1 PharmGKB related drug/compound annotation for GRK4 gene About this tableSearch CenterWatch for drugs/clinical trials and news about GRK4
|
Transcripts
for GRK4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRK4 gene (3 alternative transcripts): NM_001004056.1 NM_001004057.1 NM_182982.2 Unigene Cluster for GRK4: G protein-coupled receptor kinase 4 Hs.32959 [show with all ESTs]Unigene Representative Sequence: AK29239011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398051(uc003ggq.1) ENST00000503518(uc003ggm.3) ENST00000398052(uc003ggn.1 uc003ggo.1 uc003ggp.1)
ENST00000345167 ENST00000504933 ENST00000507230 ENST00000505271 ENST00000509545
ENST00000511827 ENST00000504308 ENST00000442472
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRK4 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRK4 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): GRK4 (NM_182982) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRK4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRK4 |
Additional cDNA sequence: AK055721.1 AK223581.1 AK292390.1 AK293569.1 BC027597.1 BC039732.1 BC063678.1 BC117320.1 U33054.1 U33055.1 U33056.1 X75897.1 X97879.1 X97880.1 X97881.1 X98118.1 10 DOTS entries: DT.101981328 DT.40220101 DT.413731 DT.86853791 DT.101979674 DT.413730 DT.40111448 DT.413729 DT.75172625 DT.97821341 24/56 AceView cDNA sequences (see all 56): BM928228 BC039732 NM_001004057 CK725053 X75897 BE502168 AI243951 BM725978 NM_001004056 W23870 NM_182982 BX279959 X97881 BC063678 AA412224 X97880 AW269179 AA024620 AI150462 X97879 BQ068267 U33055 BF343069 AI656338
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GRK4 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GRK4
|
Expression
for GRK4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTGGGAGT
About this image
See GRK4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRK4
SOURCE GeneReport for Unigene cluster: Hs.32959
UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298Tissue specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed inmyometrium
SABiosciences Custom PCR Arrays for GRK4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRK4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRK4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK4 |
Orthologs
for GRK4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GRK4 gene from 4/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GRK41 |
G protein-coupled receptor kinase 4 |
75.28(n)
75.75(a) |
|
422879 NM_001006459.1 NP_001006459.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
grk41 |
G protein-coupled receptor kinase 4 |
69.54(n)
76.66(a) |
|
100330963 XM_002660383.2 XP_002660429.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Gprk26 |
G protein-coupled receptor kinase 2 |
46(a) |
1 → many |
3R(27230971-27283499) |
worm
(Caenorhabditis elegans) |
Secernentea |
grk-16 |
G protein-coupled receptor kinase 1 |
49(a) |
1 → many |
X(9991799-9999120) |
ENSEMBL Gene Tree for GRK4 (if available)
TreeFam Gene Tree for GRK4 (if available) |
Paralogs
for GRK4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRK4 gene
- GRK72 ADRBK22 GRK52 GRK12 ADRBK12 GRK62
18/29 SIMAP similar genes for GRK4 using alignment to 3 protein entries: GRK4_HUMAN (see all proteins)
(see all similar genes):GRK5 GRK6 GRK1 GRK7 MARK4 PRKY
RPS6KA2 AKT3 KIN27 RPS6KA3 SGK2 PRKACB
PkB-like 1 ADRBK2 AKT1 AKT2 NEK6 ADRBK1
GRK4 for paralogs About GeneDecksing
|
Genomic Variants
for GRK4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRK4 (2965335 - 3042474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for GRK4: --
Human Gene Mutation Database (HGMD): GRK4
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for GRK4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRK4 for disorders About GeneDecksing
OMIM gene information: 137026
OMIM disorders: --
6  diseases for GRK4: About MalaCardshypertension aortic coarctation essential hypertension twinning
breast cancer atherosclerosis
1 disease from the University of Copenhagen DISEASES database for GRK4:Hypertension 2 Novoseek disease relationships for GRK4 gene About this table
Genetic Association Database (GAD): GRK4
Human Genome Epidemiology (HuGE) Navigator: GRK4 (19 documents)
Export disorders for GRK4 gene to outside databases
|
Publications
for GRK4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRK4 gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with GRK4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel G protein-coupled receptor kinase gene cloned from 4p16.3. (PubMed id 1338872)1, 2, 3 Ambrose C.... McDonald M.E. (1992)
- G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. (PubMed id 19520868)1, 2, 9 Villar V.A.M....Jose P.A. (2009)
- Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. (PubMed id 8626439)1, 2, 9 Premont R.T.... Lefkowitz R.J. (1996)
- G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. (PubMed id 9092566)1, 2, 9 Sallese M.... de Blasi A. (1997)
- Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. (PubMed id 8135832)1, 2, 9 Sallese M.... de Blasi A. (1994)
- Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. (PubMed id 12446468)1, 4, 9 Bengra C....Felder R.A. (2002)
- Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. (PubMed id 15097232)1, 4, 9 Speirs H.J....Morris B.J. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression. (PubMed id 16636192)2, 9 Sanada H....Jose P.A. (2006)
|
External Searches for GRK4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRK4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRK4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRK4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRK4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GRK4 gene:
Search GeneIP for patents involving GRK4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GRK4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for GRK4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRK4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRK4 | | | OriGene Protein Over-expression Lysate for GRK4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GRK4 | | OriGene 3'-UTR Clone for GRK4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRK4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRK4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GRK4 | | OriGene Custom Protein Services for GRK4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRK4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRK4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRK4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRK4 |
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| | | | Search Tocris compounds for GRK4 |
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 | | | GRK4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK4 |
|  |  |  |  | | | | ThermoFisher Antibodies for GRK4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRK4 |
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