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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRK4 Gene

protein-coding   GIFtS: 63
GCID: GC04P002967

G Protein-Coupled Receptor Kinase 4

(Previous name: G protein-coupled receptor kinase 2-like (Drosophila))
(Previous symbol: GPRK2L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
G Protein-Coupled Receptor Kinase 41 2     G Protein-Coupled Receptor Kinase 2-Like (Drosophila)1
GPRK2L1 2 3 5     GRK4a2
GPRK42 3 5     IT112
ITI12 3     G Protein-Coupled Receptor Kinase GRK43
EC 2.7.11.163 8     EC 2.7.118

External Ids:    HGNC: 45431   Entrez Gene: 28682   Ensembl: ENSG000001253887   OMIM: 1370265   UniProtKB: P322983   

Export aliases for GRK4 gene to outside databases

Previous GC identifers: GC04P002997 GC04P002996 GC04P003002


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRK4 Gene:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily
of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled
receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.
(provided by RefSeq, Jul 2008)

GeneCards Summary for GRK4 Gene: 
GRK4 (G protein-coupled receptor kinase 4) is a protein-coding gene. Diseases associated with GRK4 include aortic coarctation, and hypertension, and among its related super-pathways are Myometrial Relaxation and Contraction Pathways and GABAergic synapse. GO annotations related to this gene include G-protein coupled receptor kinase activity and rhodopsin kinase activity. An important paralog of this gene is GRK7.

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can
phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not
phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3.
Phosphorylates ADRB2

Gene Wiki entry for GRK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRK4 gene promoter:
         COUP-TF1   Nkx3-1   Nkx3-1 v4   COUP   Nkx3-1 v1   Nkx2-5   HNF-4alpha1   Nkx3-1 v2   COUP-TF   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

GRK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRK4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P002967:  view genomic region     (about GC identifiers)

Start:
2,965,335 bp from pter      End:
3,042,474 bp from pter
Size:
77,140 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298 (See protein sequence)
Recommended Name: G protein-coupled receptor kinase 4  
Size: 578 amino acids; 66583 Da
Subunit: Interacts with DRD3
Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the
cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear
area, where co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in
lipid rafts of renal proximal tubule cells
Secondary accessions: O00641 O00642 Q13293 Q13294 Q13295 Q14453 Q14725 Q15313 Q15314 Q15315
Q15316 Q17RH6 Q53EQ8
Alternative splicing: 4 isoforms:  P32298-1   P32298-2   P32298-3   P32298-4   

Explore the universe of human proteins at neXtProt for GRK4: NX_P32298

Explore proteomics data for GRK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32298

  • 4/14 DME Specific Peptides for GRK4 (P32298) (see all 14)
     MNGGDLK  LQWKWLE  TIMNGGD  IPWQNEM 

    GRK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRK4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001004056.1  NP_001004057.1  NP_892027.2  

    ENSEMBL proteins: 
     ENSP00000381128   ENSP00000421650   ENSP00000381129   ENSP00000264764   ENSP00000427445  
     ENSP00000392297  

    Human Recombinant Protein Products for GRK4: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRK4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005938cell cortex IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--

    GRK4 for ontologies           About GeneDecksing



    GRK4 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for GRK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: G protein-coupled receptor kinase 4 
    G protein coupled receptor kinases
    GRK subfamily

    5/9 InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P32298

    ProtoNet protein and cluster: P32298

    3 Blocks protein domains:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain


    UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    GRK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRK4_HUMAN, P32298
    Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can
    phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not
    phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3.
    Phosphorylates ADRB2
    Catalytic activity: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
    Enzyme regulation: Inhibited by heparin

         Enzyme Numbers (IUBMB): EC 2.7.11.161 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004703G-protein coupled receptor kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    GRK4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for GRK4:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Grk4):
     normal 

    GRK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grk4tm1Rjl for GRK4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRK4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRK4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    2Circadian entrainment
    Morphine addiction0.53
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    4Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GRK4
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell



    3         Kegg Pathways  (Kegg details for GRK4):
        Chemokine signaling pathway
    Endocytosis
    Morphine addiction


    GRK4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for GRK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for GRK4 (P322983 ENSP000003811294) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    FSHRP239453, ENSP000003847084I2D: score=1 STRING: ENSP00000384708
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002029desensitization of G-protein coupled receptor protein signaling pathway ----
    GO:0002031G-protein coupled receptor internalization IEA--
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS1338872

    GRK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRK4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for GRK4

    6 Novoseek inferred chemical compound relationships for GRK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 56.4 13 16439609 (2), 15133310 (1), 16636192 (1), 16441255 (1) (see all 8)
    dopamine 50.8 9 16439609 (1), 16461192 (1), 16441255 (1), 19520868 (1)
    baclofen 32 2 17013811 (1)
    serine 21.6 1 15521360 (1)
    glutamate 10.1 6 12519791 (2), 11099476 (2), 11431139 (1)
    cysteine 0 1 9341194 (1)

    1 PharmGKB related drug/compound annotation for GRK4 gene    About this table
    Drug/compound PharmGKB Annotation
    metoprololCA  

    Search CenterWatch for drugs/clinical trials and news about GRK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRK4 gene (3 alternative transcripts): 
    NM_001004056.1  NM_001004057.1  NM_182982.2  

    Unigene Cluster for GRK4:

    G protein-coupled receptor kinase 4
    Hs.32959  [show with all ESTs]
    Unigene Representative Sequence: AK292390
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398051(uc003ggq.1) ENST00000503518(uc003ggm.3) ENST00000398052(uc003ggn.1 uc003ggo.1 uc003ggp.1)
    ENST00000345167 ENST00000504933 ENST00000507230 ENST00000505271 ENST00000509545
    ENST00000511827 ENST00000504308 ENST00000442472
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    Additional mRNA sequence: 

    AK055721.1 AK223581.1 AK292390.1 AK293569.1 BC027597.1 BC039732.1 BC063678.1 BC117320.1 
    U33054.1 U33055.1 U33056.1 X75897.1 X97879.1 X97880.1 X97881.1 X98118.1 

    10 DOTS entries:

    DT.101981328  DT.40220101  DT.413731  DT.86853791  DT.101979674  DT.413730  DT.40111448  DT.413729 
    DT.75172625  DT.97821341 

    24/56 AceView cDNA sequences (see all 56):

    AI243951 NM_001004056 CK725053 BM725978 BC039732 NM_001004057 X75897 X97881 
    BC063678 BM928228 NM_182982 BX279959 AA412224 AW269179 BE502168 X97880 
    W23870 AI204074 AI798928 BQ068267 AK055721 U33054 AA024620 BU626334 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GRK4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                            -                 -                                                                 -               
    SP2:                          -     -           -                 -                                                                 -               
    SP3:                                            -                 -                                                           -     -               
    SP4:                          -     -           -                 -                                                           -     -               
    SP5:                          -     -     -     -                 -                                                                                 


    ECgene alternative splicing isoforms for GRK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGGGAGT
    GRK4 Expression
    About this image


    See GRK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRK4

    SOURCE GeneReport for Unigene cluster: Hs.32959

    UniProtKB/Swiss-Prot: GRK4_HUMAN, P32298
    Tissue specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed
    in myometrium

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for GRK4 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grk41 , 5 G protein-coupled receptor kinase 41, 5 80.94(n)1
    75.7(a)1
      5 (17.91 cM)5
    147721  NM_019497.21  NP_062370.21 
     346603795 
    chicken
    (Gallus gallus)
    Aves GRK41 G protein-coupled receptor kinase 4 75.28(n)
    75.75(a)
      422879  NM_001006459.1  NP_001006459.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    56(a)
    possible ortholog
    GL343406.1(702937-779485)
    zebrafish
    (Danio rerio)
    Actinopterygii grk41 G protein-coupled receptor kinase 4 69.54(n)
    76.66(a)
      100330963  XM_002660383.2  XP_002660429.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gprk26
    G protein-coupled receptor kinase 2
    48(a)
    1 → many
    3R(27230971-27283499)
    worm
    (Caenorhabditis elegans)
    Secernentea grk-16
    G protein-coupled receptor kinase 1
    49(a)
    1 → many
    X(9991857-9999178)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBF26
    DBF206
    Ser/Thr kinase involved in transcription and stres...
    Ser/Thr kinase involved in late nuclear division, ...
    19(a)
    19(a)
    many ↔ many
    many ↔ many
    VII(668189-669907)
    XVI(747306-749000)


    ENSEMBL Gene Tree for GRK4 (if available)
    TreeFam Gene Tree for GRK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRK4 gene
    GRK72  ADRBK22  GRK12  GRK52  ADRBK12  GRK62  
    18/27 SIMAP similar genes for GRK4 using alignment to 3 protein entries:     GRK4_HUMAN (see all proteins) (see all similar genes):
    GRK5    GRK6    GRK1    GRK7    MARK4    PRKY
    RPS6KA2    AKT3    KIN27    RPS6KA3    SGK2    PRKACB
    PkB-like 1    ADRBK2    AKT1    AKT2    NEK6    ADRBK1

    GRK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1788 SNPs in GRK4 are shown (see all 1788)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0405164
    ----see VAR_0405162 L P mis40--------
    VAR_0078064
    ----see VAR_0078062 V I mis40--------
    rs792522761,2
    C--2967133(+) GCCACA/GGTAGT 3 -- int10--------
    rs1864169011,2
    --2967162(+) CTTACA/GGAATT 3 -- int10--------
    rs1892156321,2
    C--2967163(+) TTACGA/GAATTG 3 -- int10--------
    rs1815330571,2
    --2967172(+) TGCTGA/CTTTCC 3 -- int10--------
    rs731894801,2
    C--2967210(+) CTGCTC/TGGACT 3 -- int13Minor allele frequency- T:0.06NA EA 242
    rs1866409671,2
    --2967211(+) TGCTCA/GGACTG 3 -- int10--------
    rs1914840041,2
    --2967262(+) CAGCCA/GGCGAT 3 -- int10--------
    rs1461118561,2
    --2967293(+) GGAGCC/TGAAGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for GRK4 (2965335 - 3042474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for GRK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662217CNV Deletion23128226
    esv2661728CNV Deletion23128226
    esv2726868CNV Deletion23290073
    nsv878453CNV Loss21882294
    nsv461163CNV Gain19166990


    Human Gene Mutation Database (HGMD): GRK4
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing GRK4
    DNA2.0 Custom Variant and Variant Library Synthesis for GRK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 137026    OMIM disorders: --

    7 diseases for GRK4:    About MalaCards
    aortic coarctation    hypertension    essential hypertension    hyperparathyroidism
    atherosclerosis    breast cancer    neuronitis


    GRK4 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for GRK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    genetic hypertension 79.4 2 16636192 (2)
    essential hypertension 61.6 17 17044852 (2), 15097232 (1), 11904438 (1), 16339846 (1) (see all 9)

    Genetic Association Database (GAD): GRK4
    Human Genome Epidemiology (HuGE) Navigator: GRK4 (19 documents)

    Export disorders for GRK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRK4 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with GRK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel G protein-coupled receptor kinase gene cloned from 4p16.3. (PubMed id 1338872)1, 2, 3 Ambrose C.... McDonald M.E. (1992)
    2. G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. (PubMed id 19520868)1, 2, 9 Villar V.A.M....Jose P.A. (2009)
    3. Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. (PubMed id 8626439)1, 2, 9 Premont R.T.... Lefkowitz R.J. (1996)
    4. G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. (PubMed id 9092566)1, 2, 9 Sallese M.... de Blasi A. (1997)
    5. The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins. (PubMed id 16461192)1, 4, 9 Zhu H....Dong Y. (2006)
    6. Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese. (PubMed id 17044852)1, 4, 9 Wang Y....Gu D. (2006)
    7. Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. (PubMed id 8135832)1, 2, 9 Sallese M.... de Blasi A. (1994)
    8. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. (PubMed id 18413491)1, 4, 9 Staessen J.A....Brand E. (2008)
    9. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. (PubMed id 12446468)1, 4, 9 Bengra C....Felder R.A. (2002)
    10. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. (PubMed id 15097232)1, 4, 9 Speirs H.J....Morris B.J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2868 HGNC: 4543 AceView: GRK4 Ensembl:ENSG00000125388 euGenes: HUgn2868
    ECgene: GRK4 Kegg: 2868 H-InvDB: GRK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRK4 gene:
    Search GeneIP for patents involving GRK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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