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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRK1 Gene

protein-coding   GIFtS: 60
GCID: GC13P114321

G protein-coupled receptor kinase 1

(Previous name: rhodopsin kinase )
(Previous symbol: RHOK)
 Explore 18 diseases affiliated with
GRK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for GRK1    

Aliases
for GRK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
G Protein-Coupled Receptor Kinase 11 2 3     Rhodopsin Kinase1 2
RHOK1 2 3 5     EC 2.7.11.143 8
RK1 2 3 5     EC 2.7.118
GPRK11 2     

External Ids:    HGNC: 100131   Entrez Gene: 60112   Ensembl: ENSG000001859747   OMIM: 1803815   UniProtKB: Q158353   

Export aliases for GRK1 gene to outside databases

Previous GC identifers: GC13P112270 GC13P113369 GC13P094760


Summaries
for GRK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for GRK1:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of
the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in
GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RK_HUMAN, Q15835
Function: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein-
coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic
vision and permits rapid adaptation to changes in illumination




Genomic Views
for GRK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_027140.6  NT_077627.3  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRK1 gene promoter:
         AML1a   ATF-2   Olf-1   AP-2gamma   GATA-1   RORalpha1   MEF-2A   CREB   deltaCREB   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GRK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

GRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRK1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P114321:  view genomic region     (about GC identifiers)

Start:
 114,321,594 bp from pter      End:
 114,438,637 bp from pter
Size:
 117,044 bases      Orientation:
 plus strand

Proteins
for GRK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RK_HUMAN, Q15835 (See protein sequence)
Recommended Name: Rhodopsin kinase precursor  
Size: 563 amino acids; 63526 Da
Subcellular location: Membrane; Lipid-anchor
Secondary accessions: Q53X14

Explore the universe of human proteins at neXtProt for GRK1: NX_Q15835

Post-translational modifications:

  • Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity).
    • Phosphorylation at Ser-21 is regulated by light and activated by cAMP1
  • Farnesylation is required for full activity (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15835

    • 4/10 DME Specific Peptides for GRK1 (Q15835) (see all 10)
     LQWKWLE  TIMNGGD  RDLKPEN  DGLFQPLL 

    GRK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002920.1  
    ENSEMBL proteins: 
     ENSP00000334876   ENSP00000445619  

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    Uscn Proteins for GRK1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--


    GRK1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for GRK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    GRK1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR000239 GPCR_kinase
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q15835

    ProtoNet protein and cluster: Q15835

    3 Blocks protein families:
    IPB000239 GPCR kinase signature
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB000961 Protein kinase C-terminal domain


    UniProtKB/Swiss-Prot: RK_HUMAN, Q15835
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RGS domain


    Function
    for GRK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RK_HUMAN, Q15835
    Function: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein-
    coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic
    vision and permits rapid adaptation to changes in illumination
    Catalytic activity: ATP + [rhodopsin] = ADP + [rhodopsin] phosphate
    Enzyme regulation: Inhibited by phosphorylation of Ser-21 (By similarity)
    Biophysicochemical properties: Kinetic parameters: KM=3.5 uM for rhodopsin; KM=10.6 uM for ATP; Vmax=1132 nmol/min/mg
    enzyme;

    Enzyme Numbers (IUBMB): EC 2.7.11.141 2 EC 2.7.112

    miRNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9147475
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004703G-protein coupled receptor kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0050254rhodopsin kinase activity IDA15946941


    GRK1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for GRK1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased HPV18 LCR reporter a  Increased colony dispersion (i 

    Animal Models:
         Mouse knock-out Grk1tm1Citb for GRK1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Grk1):
     cellular  nervous system  vision/eye 

    GRK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for GRK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Visual signal transduction- Rods
    		Visual signal transduction- Rods1.00
    		Visual signal transduction- Cones0.39
    		Phototransduction0.44
    2Endocytosis
    		Endocytosis1.00
    3Chemokine Signaling
    		Chemokine signaling pathway0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for GRK1 
        Visual signal transduction- Rods
    Visual signal transduction- Cones


    3         Kegg Pathways  (Kegg details for GRK1):
        Chemokine signaling pathway
    Endocytosis
    Phototransduction


    GRK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for GRK1 (Q158353 ENSP000003348764) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    CAV1Q031353, ENSP000003391914I2D: score=2 STRING: ENSP00000339191
    SNCBQ161433, ENSP000003080574I2D: score=1 STRING: ENSP00000308057
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IEA--
    GO:0007601visual perception IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS1656454
    GO:0008594photoreceptor cell morphogenesis IEA--


    GRK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for GRK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for GRK1

    3 HMDB Compounds for GRK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ZincZinc (see all 2)7440-66-6--
    10/18 Novoseek chemical compound relationships for GRK1 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metarhodopsin ii 80.7 6 8608127 (1), 12707280 (1), 8260489 (1), 1386362 (1) (see all 5)
    sangivamycin 76.1 4 1309646 (2), 2207073 (1), 2365059 (1)
    threonine 40.1 4 9889371 (1), 1522899 (1), 9169442 (1)
    amp-pnp 34.7 1 8634260 (1)
    cgmp 34.2 4 8383684 (1), 11152756 (1), 1765153 (1)
    serine 28.3 5 9889371 (1), 1522899 (1), 9169442 (1), 1645191 (1)
    calcium 27.7 28 7926045 (3), 9872924 (2), 7592614 (2), 17020884 (2) (see all 13)
    phytate 24.7 1 1309646 (1)
    vitamin a 24 3 11078833 (1), 7947785 (1)
    atp 18.6 7 8634260 (2), 8383684 (1), 2207073 (1), 9188705 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about GRK1 / RK 

    Transcripts
    for GRK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for GRK1 gene: 
    NM_002929.2  

    Unigene Clusters for GRK1:

    G protein-coupled receptor kinase 1
    Hs.103501 , Hs.721727  [show with all ESTs]
    Unigene Representative Sequences: AK289912, BX647503
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335678(uc010tkf.2) ENST00000545304

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: BX647503.1 

    3 DOTS entries:

    DT.40120423  DT.101967485  DT.121642968 

    3 AceView cDNA sequences:

    U63973 L77503 NM_002929 

    GeneLoc Exon Structure


    Expression
    for GRK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACCTGCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    GRK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Photoreceptor-like cells (Generation of retina...)Eye
    Photoreceptor-like cells (Generation of retina...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See GRK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRK1

    SOURCE GeneReport for Unigene clusters: Hs.103501 Hs.721727

    UniProtKB/Swiss-Prot: RK_HUMAN, Q15835
    Tissue specificity: Retinal-specific. Expressed in rods and cones cells

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    In Situ
    Assay Products:     
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    Orthologs
    for GRK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for GRK1 gene from 2/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia GRK16
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL343660.1(226386-246647)
    zebrafish
    (Danio rerio)    		 Actinopterygii grk1a1 G protein-coupled receptor kinase 1 a 68.92(n)
    67.79(a)    		   564152  NM_001034181.2  NP_001029353.2 


    ENSEMBL Gene Tree for GRK1 (if available)
    TreeFam Gene Tree for GRK1 (if available) 

    Paralogs
    for GRK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRK1 gene
    GRK72  ADRBK22  GRK52  ADRBK12  GRK42  GRK62  
    18/31 SIMAP similar genes for GRK1 using alignment to 5 protein entries:     RK_HUMAN (see all proteins) (see all similar genes):
    GRK5    GRK4    GRK6    GRK7    MARK4    RPS6KA2
    STK11    KIN27    PRKY    SGK1    STK32A    SGK2
    AKT3    RPS6KA3    PRKACB    SGKL    AKT2    DKFZp564L2416

    GRK1 for paralogs           About GeneDecksing



    Genomic Variants
    for GRK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): GRK1

    Locus Specific Mutation Databases (LSDB): GRK1
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for GRK1

    Disorders / Diseases
    for GRK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    GRK1 for disorders           About GeneDecksing

    OMIM gene information: 180381   
    OMIM disorders: 613411  
    UniProtKB/Swiss-Prot: RK_HUMAN, Q15835
  • Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type 2 (CSNBO2) [MIM:613411]. It
    • is non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and
    myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow
    dark adaptation

    18 diseases for GRK1:    About MalaCards
    night blindness    oguchi disease 2    blindness    congenital stationary night blindness
    enhanced s-cone syndrome    fundus albipunctatus    leber congenital amaurosis    avian influenza
    retinitis pigmentosa    fundus dystrophy    newcastle disease    retinal degeneration
    nystagmus    retinitis    myopia    influenza
    encephalitis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for GRK1:
    Night blindness     Leber congenital amaurosis

    5 Novoseek disease relationships for GRK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oguchis disease 93.1 20 17070587 (3), 19753316 (2), 17765441 (2), 17402561 (2) (see all 12)
    night blindness 75.3 5 11078833 (1), 10549660 (1), 9501174 (1), 16687124 (1)
    retinitis pigmentosa 62.7 2 8810231 (1), 9872421 (1)
    night blindness, congenital stationary 62.5 3 9501174 (1), 10097103 (1)
    retinopathy 34 2 9419375 (1), 19834036 (1)


    Export disorders for GRK1 gene to outside databases

    Publications
    for GRK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRK1 gene, integrated from 9 sources (see all 165):
    (articles sorted by number of sources associating them with GRK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal localization of the gene for human rhodopsin kinase. (PubMed id 8812493)1, 2, 3, 9 Khani S.C....Dryja T.P. (1996)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (2004)
    3. A novel homozygous GRK1 mutation (P391H) in 2 siblings with Oguchi disease with markedly reduced cone responses. (PubMed id 17070587)1, 2, 9 Hayashi T....Kitahara K. (2007)
    4. Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction. (PubMed id 11717351)1, 2, 9 Weiss E.R.... Osawa S. (2001)
    5. Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. (PubMed id 9147475)1, 2, 9 Zhao X....Palczewski K. (1997)
    6. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. (PubMed id 9020843)1, 2, 9 Yamamoto S.... Dryja T.P. (1997)
    7. Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities. (PubMed id 15946941)1, 2 Horner T.J....Weiss E.R. (2005)
    8. Evaluation of the rhodopsin kinase gene in patients with retinitis pigmentosa. (PubMed id 9268593)1, 2 Yamamoto S.... Dryja T.P. (1997)
    9. Molecular forms of human rhodopsin kinase (GRK1). (PubMed id 9478965)1, 9 Zhao X.... Palczewski K. (1998)
    10. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. (PubMed id 9419375)1, 9 Cideciyan A.V....Palczewski K. (1998)

    External Searches for GRK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing GRK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6011 HGNC: 10013 AceView: GRK1 Ensembl:ENSG00000185974 euGenes: HUgn6011
    ECgene: GRK1 Kegg: 6011 H-InvDB: GRK1

    Other Databases showing GRK1 gene

    (According to HUGE)
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    Specialized Databases showing GRK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for GRK1 Genetics and Cytogenetics in Oncology and Haematology
    Mutations of the RHOK genehttp://www.retina-international.org/files/sci-news/rkmut.htm

    Intellectual Property
    for GRK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for GRK1 gene:
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