Aliases for GRK1 Gene
External Ids for GRK1 Gene
Previous HGNC Symbols for GRK1 Gene
Previous GeneCards Identifiers for GRK1 Gene
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
GeneCards Summary for GRK1 Gene
GRK1 (G Protein-Coupled Receptor Kinase 1) is a Protein Coding gene. Diseases associated with GRK1 include oguchi disease-2 and hereditary night blindness. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein kinase activity and rhodopsin kinase activity. An important paralog of this gene is AKT1.
UniProtKB/Swiss-Prot for GRK1 Gene
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.