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Aliases for GRIPAP1 Gene

Aliases for GRIPAP1 Gene

  • GRIP1 Associated Protein 1 2 3 5
  • GRASP-1 3 4
  • KIAA1167 4

External Ids for GRIPAP1 Gene

Previous GeneCards Identifiers for GRIPAP1 Gene

  • GC0XM047632
  • GC0XM047090
  • GC0XM047876
  • GC0XM048586
  • GC0XM048715
  • GC0XM048830
  • GC0XM046487

Summaries for GRIPAP1 Gene

Entrez Gene Summary for GRIPAP1 Gene

  • This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]

GeneCards Summary for GRIPAP1 Gene

GRIPAP1 (GRIP1 Associated Protein 1) is a Protein Coding gene.

Gene Wiki entry for GRIPAP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIPAP1 Gene

Genomics for GRIPAP1 Gene

Regulatory Elements for GRIPAP1 Gene

Promoters for GRIPAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRIPAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIPAP1 Gene

Chromosome:
X
Start:
48,973,720 bp from pter
End:
49,002,264 bp from pter
Size:
28,545 bases
Orientation:
Minus strand

Genomic View for GRIPAP1 Gene

Genes around GRIPAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIPAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIPAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIPAP1 Gene

Proteins for GRIPAP1 Gene

  • Protein details for GRIPAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4V328-GRAP1_HUMAN
    Recommended name:
    GRIP1-associated protein 1
    Protein Accession:
    Q4V328
    Secondary Accessions:
    • A6NL78
    • Q3MJ75
    • Q4V327
    • Q4V330
    • Q5HYG1
    • Q6N046
    • Q96DH8
    • Q9NQ43
    • Q9ULQ3

    Protein attributes for GRIPAP1 Gene

    Size:
    841 amino acids
    Molecular mass:
    95990 Da
    Quaternary structure:
    • Interacts with GRIP1, GRIP2 and AMPA receptors.
    Miscellaneous:
    • Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynauds syndrome and telangiectasias.

    Alternative splice isoforms for GRIPAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIPAP1 Gene

Proteomics data for GRIPAP1 Gene at MOPED

Post-translational modifications for GRIPAP1 Gene

Antibody Products

No data available for DME Specific Peptides for GRIPAP1 Gene

Domains & Families for GRIPAP1 Gene

Protein Domains for GRIPAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRIPAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRIPAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GRIPAP1 Gene

Function for GRIPAP1 Gene

genes like me logo Genes that share phenotypes with GRIPAP1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRIPAP1 Gene

Localization for GRIPAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIPAP1 Gene COMPARTMENTS Subcellular localization image for GRIPAP1 gene
Compartment Confidence
extracellular 5
endosome 4
cytosol 3
nucleus 3
golgi apparatus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for GRIPAP1 Gene

Pathways & Interactions for GRIPAP1 Gene

SuperPathways for GRIPAP1 Gene

No Data Available

Interacting Proteins for GRIPAP1 Gene

Selected Interacting proteins: Q4V328-GRAP1_HUMAN for GRIPAP1 Gene via I2D MINT

Gene Ontology (GO) - Biological Process for GRIPAP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GRIPAP1 Gene

Drugs & Compounds for GRIPAP1 Gene

No Compound Related Data Available

Transcripts for GRIPAP1 Gene

Unigene Clusters for GRIPAP1 Gene

GRIP1 associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIPAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for GRIPAP1 Gene

GeneLoc Exon Structure for
GRIPAP1
ECgene alternative splicing isoforms for
GRIPAP1

Expression for GRIPAP1 Gene

mRNA expression in normal human tissues for GRIPAP1 Gene

Protein differential expression in normal tissues from HIPED for GRIPAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Brain (8.7), Heart (7.6), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for GRIPAP1 Gene



SOURCE GeneReport for Unigene cluster for GRIPAP1 Gene Hs.109929

genes like me logo Genes that share expression patterns with GRIPAP1: view

Protein tissue co-expression partners for GRIPAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRIPAP1 Gene

Orthologs for GRIPAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRIPAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRIPAP1 36
  • 95 (a)
OneToOne
GRIPAP1 35
  • 91.87 (n)
  • 94.89 (a)
dog
(Canis familiaris)
Mammalia GRIPAP1 35
  • 90.88 (n)
  • 94.89 (a)
GRIPAP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gripap1 16
Gripap1 36
  • 93 (a)
OneToOne
Gripap1 35
  • 88.96 (n)
  • 93.55 (a)
oppossum
(Monodelphis domestica)
Mammalia GRIPAP1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIPAP1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gripap1 35
  • 89.01 (n)
  • 93.31 (a)
lizard
(Anolis carolinensis)
Reptilia GRIPAP1 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4626 35
zebrafish
(Danio rerio)
Actinopterygii gripap1 36
  • 64 (a)
OneToOne
gripap1 35
  • 67.27 (n)
  • 68.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10814 36
  • 34 (a)
OneToOne
Species with no ortholog for GRIPAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIPAP1 Gene

ENSEMBL:
Gene Tree for GRIPAP1 (if available)
TreeFam:
Gene Tree for GRIPAP1 (if available)

Paralogs for GRIPAP1 Gene

No data available for Paralogs for GRIPAP1 Gene

Variants for GRIPAP1 Gene

Sequence variations from dbSNP and Humsavar for GRIPAP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs3027476 -- 48,981,739(-) TGGGA(A/G)GACAG intron-variant
rs3027477 -- 48,981,134(-) CCTGC(A/C)TCTTC intron-variant
rs5906732 -- 48,978,680(+) CTTGA(C/T)GTCAG intron-variant
rs7059064 -- 48,980,674(+) aggtc(A/G)ggagt intron-variant
rs7052213 -- 48,983,066(+) TGCTG(A/G)AGAGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GRIPAP1 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Variation tolerance for GRIPAP1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIPAP1 Gene

HapMap Linkage Disequilibrium report
GRIPAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Disorders for GRIPAP1 Gene

Relevant External Links for GRIPAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIPAP1

No disorders were found for GRIPAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIPAP1 Gene

Publications for GRIPAP1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. (PMID: 10896157) Ye B. … Huganir R.L. (Neuron 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3

Products for GRIPAP1 Gene

Sources for GRIPAP1 Gene

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