GRIPAP1 Gene
protein-coding GIFtS: 51
GCID: GC0XM048830
|
|
GRIP1 associated protein 1
| |
Aliases
for GRIPAP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| GRIP1 Associated Protein 11 2 | | GRASP11 5 | | GRASP-11 2 3 | | DKFZp434P06301 | | KIAA11671 3 5 | | GRIP1-Associated Protein 12 | | MPMGp800B12492Q31 2 | | |
Export aliases for GRIPAP1 gene to outside databasesPrevious GC identifers: GC0XM047632 GC0XM047090 GC0XM047876 GC0XM048586 GC0XM048715 GC0XM046487 |
Summaries
for GRIPAP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRIPAP1:
This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). In brainstudies, the encoded protein was found with the GRIP/AMPA receptor complex. Multiple alternatively spliced transcriptvariants have been described that encode different protein isoforms; however, the full-length nature and biologicalvalidity of all of these variants have not been determined.(provided by RefSeq, Nov 2009)
Gene Wiki entry for GRIPAP1
|
Genomic Views
for GRIPAP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRIPAP1 gene promoter:
AML1a Tal-1 NRSF form 1 MyoD ZIC2/Zic2 LCR-F1 NRSF form 2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRIPAP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIPAP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23GRIPAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM048830: view genomic region
(about GC identifiers)
Start:
|
48,830,134 bp from pter |
End:
|
48,858,675 bp from pter |
Size:
|
28,542 bases |
Orientation:
|
minus strand |
|
Proteins
for GRIPAP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GRAP1_HUMAN, Q4V328 (See
protein sequence)Recommended Name: GRIP1-associated protein 1 Size: 841 amino acids; 95990 Da
Subunit: Interacts with GRIP1, GRIP2 and AMPA receptors (By similarity)
Subcellular location: Early endosome
Miscellaneous: Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome andtelangiectasias
Secondary accessions: A6NL78 Q3MJ75 Q4V327 Q4V330 Q5HYG1 Q6N046 Q96DH8 Q9NQ43 Q9ULQ3Alternative splicing: 4 isoforms: Q4V328-1 Q4V328-2 Q4V328-3 Q4V328-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for GRIPAP1: NX_Q4V328
Post-translational modifications:
Proteolytically cleaved by caspase-3 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4V328
GRIPAP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_064522.3 NP_997555.1
ENSEMBL proteins: ENSP00000365608 ENSP00000365627 ENSP00000365624 ENSP00000365606
Human Recombinant Protein Products for GRIPAP1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005769 | early endosome |
IEA | -- |
GRIPAP1 for ontologies About GeneDecksing
GRIPAP1 Antibody Products:
Assay Products for GRIPAP1: |
Protein
Domains /
Families
for GRIPAP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRIPAP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4V328ProtoNet protein and cluster: Q4V328 |
Function
for GRIPAP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
GRIPAP1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for GRIPAP1:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIPAP1 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIPAP1 |
|
Pathways & Interactions
for GRIPAP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIPAP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/17 Interacting proteins for GRIPAP1 (Q4V3282, 3 ENSP000003656244) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
GRIPAP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GRIPAP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for GRIPAP1
Search CenterWatch for drugs/clinical trials and news about GRIPAP1 / GRAP1
|
Transcripts
for GRIPAP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRIPAP1 gene (2 alternative transcripts): NM_020137.3 NM_207672.1 Unigene Cluster for GRIPAP1: GRIP1 associated protein 1 Hs.109929 [show with all ESTs]Unigene Representative Sequence: NM_2076729 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376425 ENST00000376444 ENST00000376441(uc004dly.1) ENST00000473581(uc004dlz.3)
ENST00000376423(uc004dma.3) ENST00000488361 ENST00000474512 ENST00000480041
ENST00000495258
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIPAP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIPAP1 (see all 3)
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variant library, vector shuttling
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Additional cDNA sequence: AB032993.1 AJ297364.1 AK292158.1 AL136847.1 BC001522.2 BC101544.1 BC101546.1 BC110636.1 BX640704.1 BX647801.1 BX647804.1 14 DOTS entries: DT.102845483 DT.86843797 DT.101982116 DT.456168 DT.101982115 DT.100754175 DT.95356952 DT.102845484 DT.92416203 DT.97788222 DT.102845303 DT.102826325 DT.75131568 DT.92067560 24/150 AceView cDNA sequences (see all 150): AW067991 AI638277 AI799329 CN481589 AI803917 AW664647 BX280313 BU957641 NM_020137 AB032993 CF125918 BX640704 AI922001 BU838228 BQ892671 BQ006062 NM_207672 BU149446 BU789150 BU957619 F07530 AW118383 AW518228 AI674080
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for GRIPAP1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 |
|---|
|
| SP1: | | | - | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for GRIPAP1
|
Expression
for GRIPAP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRIPAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAGCGTTC
About this image
See GRIPAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRIPAP1
SOURCE GeneReport for Unigene cluster: Hs.109929
SABiosciences Custom PCR Arrays for GRIPAP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRIPAP1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIPAP1 |
Orthologs
for GRIPAP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for GRIPAP1 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
GRIPAP16 |
-- |
71(a) |
1 ↔ 1 |
GL343326.1(984943-1078658) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.46262 |
Xenopus laevis transcribed sequence with moderate similarity more |
81.68(n) |
|
BJ074575.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
gripap11 |
GRIP1 associated protein 1 |
67.35(n)
67.96(a) |
|
791150 NM_001123320.1 NP_001116792.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F41H10.41 |
Protein F41H10.4 |
39.83(n)
25.73(a) |
|
177317 NM_068389.2 NP_500790.1 |
ENSEMBL Gene Tree for GRIPAP1 (if available)
TreeFam Gene Tree for GRIPAP1 (if available) |
Paralogs
for GRIPAP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for GRIPAP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRIPAP1 (48830134 - 48858675 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for GRIPAP1
1 CNV: 7789
Locus Specific Mutation Databases (LSDB): GRIPAP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRIPAP1 |
|
Disorders
/ Diseases
for GRIPAP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRIPAP1 for disorders About GeneDecksing
OMIM gene information: 300408
OMIM disorders: --
1  disease for GRIPAP1: About MalaCardsneuronitis
Export disorders for GRIPAP1 gene to outside databases
|
Publications
for GRIPAP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRIPAP1 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with GRIPAP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes. (PubMed id 15897011)1, 2 Stinton L.M.... Fritzler M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. (PubMed id 10896157)1, 3 Ye B....Huganir R.L. (2000)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for GRIPAP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRIPAP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRIPAP1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing GRIPAP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRIPAP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for GRIPAP1 gene:
Search GeneIP for patents involving GRIPAP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRIPAP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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