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Aliases for GRIPAP1 Gene

Aliases for GRIPAP1 Gene

  • GRIP1 Associated Protein 1 2 3
  • KIAA1167 4 6
  • GRASP-1 3 4
  • GRIP1-Associated Protein 1 3
  • GRASP1 6

External Ids for GRIPAP1 Gene

Previous GeneCards Identifiers for GRIPAP1 Gene

  • GC0XM047632
  • GC0XM047090
  • GC0XM047876
  • GC0XM048586
  • GC0XM048715
  • GC0XM048830
  • GC0XM046487

Summaries for GRIPAP1 Gene

Entrez Gene Summary for GRIPAP1 Gene

  • This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]

GeneCards Summary for GRIPAP1 Gene

GRIPAP1 (GRIP1 Associated Protein 1) is a Protein Coding gene.

Gene Wiki entry for GRIPAP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIPAP1 Gene

Genomics for GRIPAP1 Gene

Regulatory Elements for GRIPAP1 Gene

Genomic Location for GRIPAP1 Gene

48,973,720 bp from pter
49,002,264 bp from pter
28,545 bases
Minus strand

Genomic View for GRIPAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIPAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIPAP1 Gene

Proteins for GRIPAP1 Gene

  • Protein details for GRIPAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRIP1-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NL78
    • Q3MJ75
    • Q4V327
    • Q4V330
    • Q5HYG1
    • Q6N046
    • Q96DH8
    • Q9NQ43
    • Q9ULQ3

    Protein attributes for GRIPAP1 Gene

    841 amino acids
    Molecular mass:
    95990 Da
    Quaternary structure:
    • Interacts with GRIP1, GRIP2 and AMPA receptors.
    • Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynauds syndrome and telangiectasias

    Alternative splice isoforms for GRIPAP1 Gene


neXtProt entry for GRIPAP1 Gene

Proteomics data for GRIPAP1 Gene at MOPED

Post-translational modifications for GRIPAP1 Gene

Antibody Products

No data available for DME Specific Peptides for GRIPAP1 Gene

Domains for GRIPAP1 Gene

Protein Domains for GRIPAP1 Gene


Suggested Antigen Peptide Sequences for GRIPAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRIPAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GRIPAP1 Gene

Function for GRIPAP1 Gene

Gene Ontology (GO) - Molecular Function for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GRIPAP1: view

Phenotypes for GRIPAP1 Gene

GenomeRNAi human phenotypes for GRIPAP1:
genes like me logo Genes that share phenotypes with GRIPAP1: view

Animal Model Products

CRISPR Products

miRNA for GRIPAP1 Gene

miRTarBase miRNAs that target GRIPAP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIPAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GRIPAP1 Gene

Localization for GRIPAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Early endosome.

Subcellular locations from

Jensen Localization Image for GRIPAP1 Gene COMPARTMENTS Subcellular localization image for GRIPAP1 gene
Compartment Confidence
endosome 5
nucleus 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with GRIPAP1: view

Pathways for GRIPAP1 Gene

SuperPathways for GRIPAP1 Gene

No Data Available

Interacting Proteins for GRIPAP1 Gene

Selected Interacting proteins: Q4V328-GRAP1_HUMAN for GRIPAP1 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GRIPAP1: view

No data available for Pathways by source for GRIPAP1 Gene

Transcripts for GRIPAP1 Gene

Unigene Clusters for GRIPAP1 Gene

GRIP1 associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIPAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIPAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP3: -
SP5: -

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP1: - - -
SP4: - -

Relevant External Links for GRIPAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRIPAP1 Gene

mRNA expression in normal human tissues for GRIPAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for GRIPAP1 Gene

SOURCE GeneReport for Unigene cluster for GRIPAP1 Gene Hs.109929

genes like me logo Genes that share expressions with GRIPAP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRIPAP1 Gene

Orthologs for GRIPAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRIPAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRIPAP1 35
  • 91.87 (n)
  • 94.89 (a)
  • 95 (a)
(Canis familiaris)
Mammalia GRIPAP1 35
  • 90.88 (n)
  • 94.89 (a)
  • 94 (a)
(Mus musculus)
Mammalia Gripap1 35
  • 88.96 (n)
  • 93.55 (a)
Gripap1 16
Gripap1 36
  • 93 (a)
(Monodelphis domestica)
Mammalia GRIPAP1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia GRIPAP1 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Gripap1 35
  • 89.01 (n)
  • 93.31 (a)
(Anolis carolinensis)
Reptilia GRIPAP1 36
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4626 35
(Danio rerio)
Actinopterygii gripap1 35
  • 67.27 (n)
  • 68.43 (a)
gripap1 36
  • 64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10814 36
  • 34 (a)
Species with no ortholog for GRIPAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIPAP1 Gene

Gene Tree for GRIPAP1 (if available)
Gene Tree for GRIPAP1 (if available)

Paralogs for GRIPAP1 Gene

No data available for Paralogs for GRIPAP1 Gene

Variants for GRIPAP1 Gene

Sequence variations from dbSNP and Humsavar for GRIPAP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3027475 -- 48,982,033(-) GCAAC(G/T)TTAGA intron-variant
rs3027476 -- 48,981,739(-) TGGGA(A/G)GACAG intron-variant
rs3027477 -- 48,981,134(-) CCTGC(A/C)TCTTC intron-variant
rs3027478 -- 48,978,470(-) GGGTA(C/T)TGGGG intron-variant
rs3027479 -- 48,974,194(-) CAGCT(A/C/G/T)AAGAC reference, stop-lost, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GRIPAP1 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Relevant External Links for GRIPAP1 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Disorders for GRIPAP1 Gene

No disorders were found for GRIPAP1 Gene.

No data available for UniProtKB/Swiss-Prot for GRIPAP1 Gene

Publications for GRIPAP1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  2. Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes. (PMID: 15897011) Stinton L.M. … Fritzler M.J. (Clin. Immunol. 2005) 3 4
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  4. GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. (PMID: 10896157) Ye B. … Huganir R.L. (Neuron 2000) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GRIPAP1 Gene

Sources for GRIPAP1 Gene

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