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Aliases for GRIP2 Gene

Aliases for GRIP2 Gene

  • Glutamate Receptor Interacting Protein 2 2 3 5
  • KIAA1719 4
  • GRIP-2 4

External Ids for GRIP2 Gene

Summaries for GRIP2 Gene

GeneCards Summary for GRIP2 Gene

GRIP2 (Glutamate Receptor Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Trafficking of AMPA receptors. GO annotations related to this gene include protein C-terminus binding and receptor signaling complex scaffold activity. An important paralog of this gene is GRIP1.

UniProtKB/Swiss-Prot for GRIP2 Gene

  • May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

Gene Wiki entry for GRIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIP2 Gene

Genomics for GRIP2 Gene

Regulatory Elements for GRIP2 Gene

Enhancers for GRIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F014508 1.2 Ensembl ENCODE 26.6 +93.8 93762 0.9 CTCF KLF1 ZNF792 KLF17 RAD21 ZKSCAN1 ZFHX2 GLIS2 POLR2A PATZ1 GRIP2 GC03M014530 RNU6-905P GC03P014432
GH03F014521 0.9 Ensembl ENCODE 25 +78.9 78907 6.1 BCOR ESRRA KLF1 INSM2 ZMYM3 NFXL1 ZFHX2 POLR2A SCRT2 ADNP GRIP2 GC03M014530 RNU6-905P GC03P014432
GH03F014531 1.1 Ensembl ENCODE 21.6 +70.0 69989 2.0 KLF1 CBX3 ETV1 ZIC2 RFX5 MAZ NR4A1 NRF1 SP2 ZBTB7A GRIP2 GC03M014530 RNU6-905P GC03P014564
GH03F014534 0.2 ENCODE 21.2 +68.0 68018 0.2 BCOR ZFHX2 ZMYM3 CTBP2 REST GRIP2 GC03M014530 RNU6-905P GC03P014564
GH03F014828 0.3 FANTOM5 7.2 -225.8 -225838 0.0 C3orf20 GRIP2 PIR49239 LOC105376963
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GRIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIP2 Gene

Chromosome:
3
Start:
14,489,111 bp from pter
End:
14,602,996 bp from pter
Size:
113,886 bases
Orientation:
Minus strand

Genomic View for GRIP2 Gene

Genes around GRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIP2 Gene

Proteins for GRIP2 Gene

  • Protein details for GRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0E4-GRIP2_HUMAN
    Recommended name:
    Glutamate receptor-interacting protein 2
    Protein Accession:
    Q9C0E4
    Secondary Accessions:
    • Q8TEH9
    • Q9H7H3

    Protein attributes for GRIP2 Gene

    Size:
    1043 amino acids
    Molecular mass:
    112501 Da
    Quaternary structure:
    • Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the C-terminal tail of PRLHR.
    SequenceCaution:
    • Sequence=BAB21810.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GRIP2 Gene

    Alternative splice isoforms for GRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIP2 Gene

Post-translational modifications for GRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRIP2 Gene

Domains & Families for GRIP2 Gene

Gene Families for GRIP2 Gene

Protein Domains for GRIP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GRIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0E4

UniProtKB/Swiss-Prot:

GRIP2_HUMAN :
  • PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity).
  • Belongs to the GRIP2 family.
Domain:
  • PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity).
  • Contains 7 PDZ (DHR) domains.
Family:
  • Belongs to the GRIP2 family.
genes like me logo Genes that share domains with GRIP2: view

Function for GRIP2 Gene

Molecular function for GRIP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

Gene Ontology (GO) - Molecular Function for GRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030159 receptor signaling complex scaffold activity IEA --
genes like me logo Genes that share ontologies with GRIP2: view
genes like me logo Genes that share phenotypes with GRIP2: view

Animal Models for GRIP2 Gene

MGI Knock Outs for GRIP2:

Animal Model Products

miRNA for GRIP2 Gene

miRTarBase miRNAs that target GRIP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIP2 Gene

Localization for GRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIP2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Gene Ontology (GO) - Cellular Components for GRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with GRIP2: view

No data available for Subcellular locations from COMPARTMENTS for GRIP2 Gene

Pathways & Interactions for GRIP2 Gene

genes like me logo Genes that share pathways with GRIP2: view

Interacting Proteins for GRIP2 Gene

Gene Ontology (GO) - Biological Process for GRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014824 artery smooth muscle contraction IEA --
GO:0015031 protein transport IEA --
GO:0045777 positive regulation of blood pressure IEA --
genes like me logo Genes that share ontologies with GRIP2: view

No data available for SIGNOR curated interactions for GRIP2 Gene

Transcripts for GRIP2 Gene

Unigene Clusters for GRIP2 Gene

Glutamate receptor interacting protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for GRIP2 Gene

GeneLoc Exon Structure for
GRIP2
ECgene alternative splicing isoforms for
GRIP2

Expression for GRIP2 Gene

mRNA expression in normal human tissues for GRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIP2 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.7) and Muscle - Skeletal (x5.8).

Protein differential expression in normal tissues from HIPED for GRIP2 Gene

This gene is overexpressed in Heart (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRIP2 Gene



Protein tissue co-expression partners for GRIP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GRIP2 Gene:

GRIP2

SOURCE GeneReport for Unigene cluster for GRIP2 Gene:

Hs.517819
genes like me logo Genes that share expression patterns with GRIP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GRIP2 Gene

Orthologs for GRIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIP2 34
  • 98.8 (n)
dog
(Canis familiaris)
Mammalia GRIP2 34
  • 89.49 (n)
cow
(Bos Taurus)
Mammalia GRIP2 34
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Grip2 34
  • 83.61 (n)
mouse
(Mus musculus)
Mammalia Grip2 34 16
  • 83.46 (n)
chicken
(Gallus gallus)
Aves GRIP2 34
  • 72.4 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia grip2 34
  • 69.35 (n)
zebrafish
(Danio rerio)
Actinopterygii grip2b 34
  • 66.53 (n)
wufi03h07 34
Species where no ortholog for GRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIP2 Gene

ENSEMBL:
Gene Tree for GRIP2 (if available)
TreeFam:
Gene Tree for GRIP2 (if available)

Paralogs for GRIP2 Gene

Paralogs for GRIP2 Gene

(1) SIMAP similar genes for GRIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRIP2: view

Variants for GRIP2 Gene

Sequence variations from dbSNP and Humsavar for GRIP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10510428 -- 14,576,418(+) ACCCA(C/T)TTCAC intron-variant
rs10574975 -- 14,587,640(+) TCTCC(-/A)AAAAA intron-variant, downstream-variant-500B
rs10641106 -- 14,502,494(+) AAAAA(-/A)GAGAG intron-variant
rs10656368 -- 14,514,252(+) CTCAG(-/TT/TTAG)AGAGT intron-variant
rs10716095 -- 14,490,142(+) GTACT(-/G)GGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GRIP2 Gene

Variant ID Type Subtype PubMed ID
esv2724945 CNV deletion 23290073
nsv1072671 CNV deletion 25765185
nsv1123628 CNV deletion 24896259
nsv3712 CNV insertion 18451855
nsv460447 CNV loss 19166990
nsv470427 CNV loss 18288195
nsv518216 CNV loss 19592680
nsv521453 CNV loss 19592680
nsv525798 CNV gain 19592680
nsv589772 CNV loss 21841781
nsv822002 CNV gain 20364138

Relevant External Links for GRIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GRIP2 Gene

Disorders for GRIP2 Gene

Relevant External Links for GRIP2

Genetic Association Database (GAD)
GRIP2
Human Genome Epidemiology (HuGE) Navigator
GRIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIP2

No disorders were found for GRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIP2 Gene

Publications for GRIP2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  4. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin S.H.S. … Civelli O. (Mol. Pharmacol. 2001) 3 4 64
  5. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4 64

Products for GRIP2 Gene

Sources for GRIP2 Gene

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