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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

GRIP1 Gene

protein-coding GIFtS: 59
GCID: GC12M066741

glutamate receptor interacting protein 1

Explore 15 diseases affiliated with
GRIP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glutamate Receptor Interacting Protein 1¹ ²
GRIP²
Glutamate Receptor-Interacting Protein 1²
GRIP-1³

External Ids:	HGNC: 18708¹	Entrez Gene: 23426²	Ensembl: ENSG00000155974⁷	OMIM: 604597⁵	UniProtKB: Q9Y3R0³

Export aliases for GRIP1 gene to outside databases

Previous GC identifers: GC12M066134 GC12U900033 GC12M066459 GC12M065028 GC12M063792

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRIP1:

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to

and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced

transcript variants encoding different isoforms have been described. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: GRIP1_HUMAN, Q9Y3R0

Function: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator

of the trafficking of its binding partners at specific subcellular location in neurons

Gene Wiki entry for GRIP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the GRIP1 gene promoter:
COUP-TF1 COUP HNF-4alpha2 Tal-1beta HNF-4alpha1 AREB6 S8 COUP-TF ITF-2 FOXO1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for GRIP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3 Ensembl cytogenetic band: 12q14.3 HGNC cytogenetic band: 12q13.13

GRIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIP1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M066741: view genomic region (about GC identifiers)

Start:	66,741,211 bp from pter	End:	67,197,966 bp from pter
Size:	456,756 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRIP1_HUMAN, Q9Y3R0 (See protein sequence)

Recommended Name: Glutamate receptor-interacting protein 1

Size: 1128 amino acids; 122422 Da

Subunit: Interacts with EPHA7, EPHB2, KIF5A, KIF5B, KIF5C, GRIA2, GRIA3, GRIPAP1/GRASP1, PPFIA1, PPFIA4, FRAS1, PLCD4,

PTPRF and liprins-alpha. Can form homomultimers or heteromultimers with GRIP2. Forms a ternary complex with GRIA2 and

CSPG4 (By similarity). Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts

binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly (By similarity). Interacts with EFNB1, EFNB3 and

the C-terminal tail of PRLHR. Interacts with SLC30A9 (By similarity)

Subcellular location: Cytoplasmic vesicle. Endoplasmic reticulum. Cell junction, synapse, postsynaptic cell membrane

(By similarity). Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic

reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity)

1 PDB 3D structure from and Proteopedia for GRIP1:

2JIL (3D)

Secondary accessions: C9JT59 Q1RLM0

Alternative splicing: 3 isoforms: Q9Y3R0-1 Q9Y3R0-2 Q9Y3R0-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRIP1: NX_Q9Y3R0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y3R0

GRIP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001171545.1 NP_066973.2

ENSEMBL proteins:

ENSP00000381098 ENSP00000439053 ENSP00000443006 ENSP00000446047 ENSP00000446024

ENSP00000446011 ENSP00000443860 ENSP00000440918 ENSP00000439124 ENSP00000438500

ENSP00000443392 ENSP00000438921 ENSP00000446067 ENSP00000352780 ENSP00000286445

Reactome Protein details: Q9Y3R0
Human Recombinant Protein Products:

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	Novus Biologicals GRIP1 Protein Novus Biologicals GRIP1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for GRIP1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--

GRIP1 for ontologies About GeneDecksing

GRIP1 Antibody Products:

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	Search for Antibodies for GRIP1 at Abcam
	Uscn Antibodies for GRIP1
	ThermoFisher Antibody for GRIP1

Assay Products for GRIP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for GRIP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for GRIP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

GRIP1 for domains About GeneDecksing

1 InterPro domain/family:

IPR001478 PDZ

Graphical View of Domain Structure for InterPro Entry Q9Y3R0

ProtoNet protein and cluster: Q9Y3R0

1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: GRIP1_HUMAN, Q9Y3R0

Domain: PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1

and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate

homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates

interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding

motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR

Similarity: Contains 7 PDZ (DHR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRIP1_HUMAN, Q9Y3R0

Function: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator

of the trafficking of its binding partners at specific subcellular location in neurons

miRNA Products:		OriGene 3'-UTR Clone: GRIP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat GRIP1
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate GRIP1 (see all 44):
		hsa-miR-548j hsa-miR-361-5p hsa-miR-429 hsa-miR-548k hsa-miR-29a hsa-let-7a-2* hsa-miR-218 hsa-miR-548l

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for GRIP1

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		GenScript: all cDNA clones in your preferred vector (see all 2): GRIP1 (NM_015272)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for GRIP1
		Search LifeMap BioReagents cell lines for GRIP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIP1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	NAS	15572661
GO:0005515	protein binding	--	--
GO:0008013	beta-catenin binding	TAS	16344550
GO:0008022	protein C-terminus binding	IPI	16344550
GO:0030159	receptor signaling complex scaffold activity	NAS	10197531

GRIP1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Grip1^tm1Rha for GRIP1
     10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Grip1):

cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism	integument
limbs/digits/tail	mortality/aging	nervous system	renal/urinary system	vision/eye

GRIP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity

	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	1.00			Trafficking of GluR2-containing AMPA receptors	0.53
	Trafficking of AMPA receptors	1.00

Selected targets of ESR1

Selected targets of ESR1

1.00

Apoptotic Pathways in Synovial Fibroblasts

Nuclear Receptor Activation by Vitamin-A

0.57

Assembly of RNA Polymerase-II Initiation Complex

Crosstalk Between CARM1 and ESRs

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for GRIP1

Selected targets of ESR1

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIP1

	Nuclear Receptor Activation by Vitamin-A
	Glucocorticoid Receptor Signaling
	Crosstalk Between CARM1 and ESRs

5/6 Reactome Pathways for GRIP1 (see all 6)

	Trafficking of AMPA receptors
	Transmission across Chemical Synapses
	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

GRIP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for GRIP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/94 Interacting proteins for GRIP1 (Q9Y3R0^{2, 3} ENSP00000381098⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 94)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³, ENSP00000350275⁴	I2D: score=1 STRING: ENSP00000350275
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007268	synaptic transmission	TAS	--
GO:0008104	protein localization	IEA	--
GO:0030521	androgen receptor signaling pathway	NAS	15572661
GO:0035556	intracellular signal transduction	NAS	10197531
GO:0045893	positive regulation of transcription, DNA-dependent	NAS	15572661

GRIP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

GRIP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for GRIP1
9 Novoseek chemical compound relationships for GRIP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glutamate	68.8	52	17093100 (2), 16157387 (2), 17121843 (2), 11641419 (1) (see all 33)
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid	49.9	1	9768844 (1)
nmda	49.3	3	10414325 (1), 18160640 (1), 9687358 (1)
1,25 dihydroxy vitamin d3	28.5	1	14726489 (1)
okadaic acid	24.7	2	11641419 (1)
steroid	23.3	5	16547076 (1), 12060666 (1), 15313931 (1)
kainate	13.8	3	12597860 (2), 12941441 (1)
tyrosine	10.1	2	11931740 (1), 19534761 (1)
serine	7.58	3	17303296 (1)

Search CenterWatch for drugs/clinical trials and news about GRIP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for GRIP1 gene (2 alternative transcripts):

NM_001178074.1 NM_021150.3

Unigene Cluster for GRIP1:

Glutamate receptor interacting protein 1

Hs.505946 [show with all ESTs]

Unigene Representative Sequence: NM_021150

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000398016 ENST00000538164 ENST00000540854 ENST00000538211(uc001stl.1)

ENST00000535323 ENST00000540433(uc010sta.1) ENST00000536215 ENST00000541299

ENST00000542021 ENST00000543172 ENST00000535002 ENST00000545666 ENST00000542309

ENST00000539540 ENST00000541947 ENST00000538373 ENST00000359742(uc001stk.3)

ENST00000286445(uc001stj.3 uc001stm.3)

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		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate GRIP1 (see all 44):
		hsa-miR-548j hsa-miR-361-5p hsa-miR-429 hsa-miR-548k hsa-miR-29a hsa-let-7a-2* hsa-miR-218 hsa-miR-548l

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIP1

Additional cDNA sequence:

AF074996.1 AJ133439.1 AK095519.1 AK295565.1 AK307576.1 BC029871.1 BC115393.1 BC115394.1

6 DOTS entries:

DT.100751109 DT.453167 DT.121159566 DT.95256235 DT.40131604 DT.121159564

1 AceView cDNA sequence:

BX281923

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GRIP1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	·	23c
SP1:																																									-
SP2:													-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:

ECgene alternative splicing isoforms for GRIP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

GRIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATTTATCG

About this image
See GRIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRIP1

SOURCE GeneReport for Unigene cluster: Hs.505946

SABiosciences Expression via Pathway-Focused PCR Array including GRIP1:

Synaptic Plasticity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for GRIP1 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Grip1^{1 , 5}	glutamate receptor interacting protein 1^{1, 5}	89.33(n)¹ 96.47(a)¹		10 (67.33 cM)⁵ 74053¹ NM_028736.1¹ NP_083012.1¹ 119454034⁵
chicken (Gallus gallus)	Aves	GRIP1¹	glutamate receptor interacting protein 1	81.11(n) 89.82(a)		427863 XM_425437.2 XP_425437.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	86(a) 81(a)	many → 1 many → 1	GL343256.1(405730-471446) GL343256.1(375992-395463)
zebrafish (Danio rerio)	Actinopterygii	grip1¹	glutamate receptor interacting protein 1	71.69(n) 80.69(a)		558006 NM_001044851.1 NP_001038316.1
fruit fly (Drosophila melanogaster)	Insecta	Grip¹	Glutamate receptor binding protein	47.25(n) 41.9(a)		50391 NM_132057.2 NP_572285.2

ENSEMBL Gene Tree for GRIP1 (if available)
TreeFam Gene Tree for GRIP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for GRIP1 gene

11 SIMAP similar genes for GRIP1 using alignment to 14 protein entries: GRIP1_HUMAN (see all proteins):

LGALS12 GRIP2 IL16 DLG2 LGALS7 LGALS7B

TJP2 DLG4 PDLIM7 MPDZ LGALS2

GRIP1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for GRIP1
PGOHUM00000259815 PGOHUM00000259816

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114649227^1,2	C,F,	--	63793168(+)	`CCTATG/TAGAAG`	2	--	ut3¹		1		WA	118
rs78619935^1,2	F,	--	63793178(+)	`GAAAAG/ACTTTG`	2	--	ut3¹		1		EA	120
rs200232418^1,2	C	--	63793507(+)	`TGCCAC/TGNNNN`	2	--	ut3¹		0	--	--	--	--
rs7309726^1,2	C,F,H,	--	63793944(+)	`TAAAAT/CGAGCG`	2	--	int¹		14		NS EA NA WA	1528
rs12312831^1,2		--	63794375(+)	`accagC/Tctggg`	2	--	int¹		0	--	--	--	--
rs112146120^1,2	C,	--	63794421(+)	`TTTTTA/TAAAAA`	2	--	int¹		3		WA EA	240
rs73331014^1,2	C,	--	63794457(+)	`TACATG/TCACCC`	2	--	int¹		2		WA	120
rs113751438^1,2		--	63795006(+)	`CGCTTC/GAACCT`	2	--	int¹		1		CSA	1
rs78739143^1,2	F,	--	63795790(+)	`CCTGAA/GAGCCA`	2	--	int¹		1		WA	118
rs7967591^1,2	C,	--	63796180(+)	`tgcacC/Tcaggc`	2	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for GRIP1 (66741211 - 66991211 bp, first 250kb of GRIP1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for GRIP1
     7 CNVs: 5673 9209 2989 86437 66255 38265 6990
     8 Indels: 71528 86434 66254 33256 86438 71527 86436 86435
     1 Inversion: 59711
Human Gene Mutation Database (HGMD): GRIP1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

GRIP1 for disorders           About GeneDecksing

OMIM gene information: 604597    OMIM disorders: --

15 diseases for GRIP1:    About MalaCards

cryptophthalmos epidermolysis bullosa renal agenesis fraser syndrome

amyotrophic lateral sclerosis lateral sclerosis syndactyly sporadic breast cancer

rickets breast cancer schizophrenia alzheimer's disease

cerebritis thyroiditis neuronitis

1 disease from the University of Copenhagen DISEASES database for GRIP1:

Anosognosia

7 Novoseek disease relationships for GRIP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fraser syndrome	78.2	5	18155042 (2)
cryptophthalmos	72.5	2	14730302 (1)
renal agenesis	46.9	2	14730302 (1)
syndactyly	44.1	2	14730302 (1)
genetic disorder	21.6	1	18155042 (1)
schizophrenia	0	13	17303296 (6), 15696539 (1)
breast cancer	0	1	15313931 (1)

Human Genome Epidemiology (HuGE) Navigator: GRIP1 (18 documents)

Export disorders for GRIP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GRIP1 gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with GRIP1)

Utopia: connect your pdf to the dynamic
world of online information

EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. (PubMed id 10197531)^{1, 2, 3, 9} Brueckner K....Klein R. (1999)
The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PubMed id 11641419)^{1, 2, 9} Lin S.H.S.... Civelli O. (2001)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (2006)
No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population. (PubMed id 17303296)^{1, 9} Tsai S.J....Hong C.J. (2007)
Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1. (PubMed id 18155042)^{1, 9} Long J....Zhang M. (2008)
The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1. (PubMed id 12060666)^{1, 9} Kotaja N....Palvimo J.J. (2002)
Effect of cellular environment on the selective activation of the vitamin D receptor by 1alpha,25-dihydroxyvitamin D3 and its analog 1alpha-fluoro-16-ene-20-epi-23-ene-26,27-bishomo-25-hydroxyvita min D3 (Ro-26-9228). (PubMed id 14726489)^{1, 9} Ismail A....Peleg S. (2004)
Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. (PubMed id 12597860)^{1, 9} Hirbec H....Couthino V. (2003)
Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. (PubMed id 12114525)^{1, 9} Min G....Kemper J.K. (2002)
Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. (PubMed id 15557560)^{1, 9} Sugatani J....Miwa M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23426	HGNC: 18708	AceView: GRIP1.2	Ensembl:ENSG00000155974	euGenes: HUgn23426
ECgene: GRIP1	H-InvDB: GRIP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for GRIP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for GRIP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for GRIP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GRIP1 gene:
Search GeneIP for patents involving GRIP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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glutamate receptor interacting protein 1

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glutamate receptor interacting protein 1

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