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Aliases for GRINA Gene

Aliases for GRINA Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1 2 3
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3 5
  • Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
  • Transmembrane BAX Inhibitor Motif Containing 3 2 3
  • Glutamate [NMDA] Receptor-Associated Protein 1 3 4
  • NMDA Receptor Glutamate-Binding Subunit 3 4
  • Putative MAPK-Activating Protein PM02 3 4
  • NMDARA1 3 4
  • TMBIM3 3 4
  • LFG1 3 4
  • Glutamate Receptor, NMDA Subtype, Glutamate-Binding Subunit 3
  • HNRGW 3

External Ids for GRINA Gene

Previous HGNC Symbols for GRINA Gene


Previous GeneCards Identifiers for GRINA Gene

  • GC08U990038
  • GC08M145371
  • GC08P144839
  • GC08P145170
  • GC08P145171
  • GC08P145136
  • GC08P145064
  • GC08P140305

Summaries for GRINA Gene

GeneCards Summary for GRINA Gene

GRINA (Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1) is a Protein Coding gene. Among its related pathways are CREB Pathway and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include ion channel binding. An important paralog of this gene is FAIM2.

UniProtKB/Swiss-Prot for GRINA Gene

  • Potential apoptotic regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene

Genomics for GRINA Gene

Regulatory Elements for GRINA Gene

Promoters for GRINA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRINA on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GRINA gene promoter:

Genomic Location for GRINA Gene

143,990,058 bp from pter
143,993,419 bp from pter
3,362 bases
Plus strand

Genomic View for GRINA Gene

Genes around GRINA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRINA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRINA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRINA Gene

Proteins for GRINA Gene

  • Protein details for GRINA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 1
    Protein Accession:
    Secondary Accessions:
    • B3KXM7
    • O43836
    • Q8IVW7

    Protein attributes for GRINA Gene

    371 amino acids
    Molecular mass:
    41203 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};

neXtProt entry for GRINA Gene

Proteomics data for GRINA Gene at MOPED

Post-translational modifications for GRINA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRINA Gene

Domains & Families for GRINA Gene

Gene Families for GRINA Gene

Protein Domains for GRINA Gene


Suggested Antigen Peptide Sequences for GRINA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with GRINA: view

Function for GRINA Gene

Molecular function for GRINA Gene

GENATLAS Biochemistry:
N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit
UniProtKB/Swiss-Prot Function:
Potential apoptotic regulator.
genes like me logo Genes that share phenotypes with GRINA: view

Animal Models for GRINA Gene

MGI Knock Outs for GRINA:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRINA Gene

Localization for GRINA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRINA Gene COMPARTMENTS Subcellular localization image for GRINA gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with GRINA: view

Pathways & Interactions for GRINA Gene

genes like me logo Genes that share pathways with GRINA: view

Interacting Proteins for GRINA Gene

Gene Ontology (GO) - Biological Process for GRINA Gene


No data available for SIGNOR curated interactions for GRINA Gene

Drugs & Compounds for GRINA Gene

No Compound Related Data Available

Transcripts for GRINA Gene

Unigene Clusters for GRINA Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRINA Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for GRINA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRINA Gene

mRNA expression in normal human tissues for GRINA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRINA Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for GRINA Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRINA Gene

SOURCE GeneReport for Unigene cluster for GRINA Gene Hs.594634

genes like me logo Genes that share expression patterns with GRINA: view

Protein tissue co-expression partners for GRINA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRINA Gene

Orthologs for GRINA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRINA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRINA 35
  • 91.17 (n)
  • 92.62 (a)
  • 93 (a)
(Canis familiaris)
Mammalia GRINA 35
  • 90.54 (n)
  • 95.22 (a)
  • 95 (a)
(Mus musculus)
Mammalia Grina 35
  • 87.73 (n)
  • 92.17 (a)
Grina 16
Grina 36
  • 94 (a)
(Pan troglodytes)
Mammalia GRINA 35
  • 99.46 (n)
  • 98.92 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Grina 35
  • 89.56 (n)
  • 94.25 (a)
(Monodelphis domestica)
Mammalia GRINA 36
  • 83 (a)
(Anolis carolinensis)
Reptilia GRINA 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1396 35
African clawed frog
(Xenopus laevis)
Amphibia grina-prov 35
(Danio rerio)
Actinopterygii zgc64102 35
zgc:136572 35
  • 68.41 (n)
  • 70.15 (a)
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmda1 35
  • 54.83 (n)
  • 50.16 (a)
CG3814 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 36
  • 24 (a)
Species with no ortholog for GRINA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRINA Gene

Gene Tree for GRINA (if available)
Gene Tree for GRINA (if available)

Paralogs for GRINA Gene

Paralogs for GRINA Gene

(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GRINA: view

Variants for GRINA Gene

Sequence variations from dbSNP and Humsavar for GRINA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs17854152 - 143,991,543(+) CCAGA(A/G/T)CCCCT reference, missense
rs9100 -- 143,993,299(-) TAAGA(A/C)CCCCA utr-variant-3-prime
rs3211273 -- 143,992,273(-) CCACC(A/G)TGTAC reference, missense
rs3211274 -- 143,991,959(-) GACAA(A/G)GCCCT reference, missense
rs3211275 -- 143,991,892(-) AAGGT(C/T)AGCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for GRINA Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
dgv7943n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv906n27 CNV Loss 19166990
nsv470249 CNV Loss 18288195
dgv7947n71 CNV Loss 21882294
dgv7948n71 CNV Loss 21882294
dgv7949n71 CNV Loss 21882294
dgv7950n71 CNV Loss 21882294
dgv7951n71 CNV Gain+Loss 21882294
nsv891787 CNV Gain+Loss 21882294
nsv515809 CNV Gain+Loss 19592680
nsv470250 CNV Gain 18288195
nsv6445 CNV Insertion 18451855

Variation tolerance for GRINA Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRINA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene

Disorders for GRINA Gene

Relevant External Links for GRINA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRINA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene

Publications for GRINA Gene

  1. Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C. … Hayden M.R. (Genomics 1993) 2 3 4 23 67
  2. Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar K.N. … Michaelis E.K. (Nature 1991) 2 3
  3. The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CAA^a8_-filling state. (PMID: 25764978) Lisak D.A. … Methner A. (Biochim. Biophys. Acta 2015) 3
  4. Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures. (PMID: 23267846) Shin A.H. … Thayer S.A. (Mol. Cell. Neurosci. 2013) 3
  5. Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure. (PMID: 24086760) Shepherd A.J. … Mohapatra D.P. (PLoS ONE 2013) 3

Products for GRINA Gene

Sources for GRINA Gene

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