Aliases for GRINA Gene
Aliases for GRINA Gene
- Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1 2 3 5
- Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3
- Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
- Transmembrane BAX Inhibitor Motif Containing 3 2 3
- Glutamate [NMDA] Receptor-Associated Protein 1 3 4
- NMDA Receptor Glutamate-Binding Subunit 3 4
- Putative MAPK-Activating Protein PM02 3 4
External Ids for GRINA Gene
- HGNC: 4589
- Entrez Gene: 2907
- Ensembl: ENSG00000178719
- OMIM: 138251
- UniProtKB: Q7Z429
Previous HGNC Symbols for GRINA Gene
- NMDARA1
Previous GeneCards Identifiers for GRINA Gene
- GC08U990038
- GC08M145371
- GC08P144839
- GC08P145170
- GC08P145171
- GC08P145136
- GC08P145064
- GC08P140305
Summaries for GRINA Gene
GeneCards Summary for GRINA Gene
GRINA (Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1) is a Protein Coding gene. Among its related pathways are Amyotrophic lateral sclerosis (ALS) and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is TMBIM1.
UniProtKB/Swiss-Prot for GRINA Gene
-
Potential apoptotic regulator.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene
Genomics for GRINA Gene
GeneHancer (GH) Regulatory Elements for GRINA Gene
Regulatory Element Products
Genomic Locations for GRINA Gene
- chr8:143,990,058-143,993,419
- (GRCh38/hg38)
- Size:
- 3,362 bases
- Orientation:
- Plus strand
- chr8:145,064,226-145,067,583
- (GRCh37/hg19)
Genomic View for GRINA Gene
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC


RefSeq DNA sequence for GRINA Gene
Proteins for GRINA Gene
-
Protein details for GRINA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z429-LFG1_HUMAN
- Recommended name:
- Protein lifeguard 1
- Protein Accession:
- Q7Z429
- B3KXM7
- O43836
- Q8IVW7
Protein attributes for GRINA Gene
- Size:
- 371 amino acids
- Molecular mass:
- 41203 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};
Protein Expression for GRINA Gene
Post-translational modifications for GRINA Gene
Other Protein References for GRINA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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No data available for DME Specific Peptides for GRINA Gene
Domains & Families for GRINA Gene
Gene Families for GRINA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GRINA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRINA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z429- Family:
-
- Belongs to the BI1 family. LFG subfamily.
Function for GRINA Gene
Molecular function for GRINA Gene
- GENATLAS Biochemistry:
- N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit
- UniProtKB/Swiss-Prot Function:
- Potential apoptotic regulator.
Phenotypes From GWAS Catalog for GRINA Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0044325 | ion channel binding | IEA | -- |
Phenotypes for GRINA Gene
- MGI mutant phenotypes for GRINA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRINA:
-
- Increased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Salmonella enterica Typhimurium invasion
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
Animal Models for GRINA Gene
- MGI Knock Outs for GRINA:
-
- Grina tm1.1Ldh
Animal Model Products
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-
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miRNA for GRINA Gene
- miRTarBase miRNAs that target GRINA
-
- hsa-mir-7-5p (MIRT025808)
- hsa-mir-296-3p (MIRT038514)
- hsa-mir-106b-3p (MIRT038571)
- hsa-mir-125b-5p (MIRT046002)
- hsa-mir-34a-5p (MIRT047387)
- hsa-mir-10b-5p (MIRT047457)
- hsa-mir-3127-5p (MIRT476056)
- hsa-mir-4290 (MIRT476057)
- hsa-mir-4518 (MIRT476058)
- hsa-mir-6859-3p (MIRT476059)
- hsa-mir-1266-5p (MIRT476060)
- hsa-mir-3918 (MIRT476061)
- hsa-mir-383-3p (MIRT476062)
- hsa-mir-3065-3p (MIRT476063)
- hsa-mir-548ao-3p (MIRT476064)
- hsa-mir-3667-5p (MIRT476065)
- hsa-mir-24-3p (MIRT476066)
- hsa-mir-4665-5p (MIRT489757)
- hsa-mir-1275 (MIRT489758)
- hsa-mir-4472 (MIRT489759)
- hsa-mir-4447 (MIRT489760)
- hsa-mir-92a-2-5p (MIRT489761)
- hsa-mir-5010-5p (MIRT489762)
- hsa-mir-4525 (MIRT489763)
- hsa-mir-6870-5p (MIRT489764)
- hsa-mir-7111-5p (MIRT489765)
- hsa-mir-5698 (MIRT489766)
- hsa-mir-4723-5p (MIRT489767)
- hsa-mir-625-5p (MIRT489768)
- hsa-mir-6825-5p (MIRT489769)
- hsa-mir-939-5p (MIRT489770)
- hsa-mir-1343-5p (MIRT489771)
- hsa-mir-6780b-5p (MIRT489772)
- hsa-mir-4725-3p (MIRT489773)
- hsa-mir-4271 (MIRT489774)
- hsa-mir-6799-5p (MIRT489775)
- hsa-mir-6827-5p (MIRT489776)
- hsa-mir-4747-5p (MIRT489777)
- hsa-mir-5196-5p (MIRT489778)
- hsa-mir-6851-5p (MIRT489779)
- hsa-mir-3689d (MIRT489780)
- hsa-mir-3202 (MIRT489781)
- hsa-mir-6134 (MIRT489782)
- hsa-mir-3179 (MIRT489783)
- hsa-mir-6794-5p (MIRT489784)
- hsa-mir-4716-3p (MIRT489785)
miRNA Products
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRINA Gene
Localization for GRINA Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene
- Membrane; Multi-pass membrane protein.
- Cytosol (2)
- Nucleoli fibrillar center (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GRINA Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
2 | fMLP Pathway | ||
3 | CREB Pathway | ||
4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
5 | nNOS Signaling at Neuronal Synapses |
Pathways by source for GRINA Gene
Interacting Proteins for GRINA Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032469 | endoplasmic reticulum calcium ion homeostasis | IEA | -- |
GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for GRINA Gene
Transcripts for GRINA Gene
mRNA/cDNA for GRINA Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (475) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GRINA Gene
CRISPR Products
-
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-
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-
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miRNA Products
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Clone Products
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- Applied Biological Materials Clones for GRINA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||
SP9: |
Expression for GRINA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for GRINA Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRINA Gene
NURSA nuclear receptor signaling pathways regulating expression of GRINA Gene:
GRINASOURCE GeneReport for Unigene cluster for GRINA Gene:
Hs.594634Evidence on tissue expression from TISSUES for GRINA Gene
- Pancreas(4.8)
- Lung(4.6)
- Kidney(4.5)
- Liver(4.5)
- Nervous system(4.4)
- Skin(3.4)
- Eye(3)
- Intestine(2.1)
- Bone marrow(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for GRINA
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No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRINA Gene
Orthologs for GRINA Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GRINA 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | GRINA 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GRINA 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Grina 33 |
|
||
mouse (Mus musculus) |
Mammalia | Grina 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | GRINA 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | GRINA 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1396 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | grina-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | zgc:136572 33 |
|
||
GRINA 34 |
|
OneToOne | |||
zgc64102 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | Nmda1 33 |
|
||
CG3814 34 |
|
ManyToMany | |||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BXI1 34 |
|
OneToMany |
- Species where no ortholog for GRINA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GRINA Gene
(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:
Variants for GRINA Gene
SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000602570 | -- | 143,990,929(+) | A/G | intron_variant | |
rs1001264450 | -- | 143,993,141(+) | G/T | 3_prime_UTR_variant | |
rs1002271584 | -- | 143,992,192(+) | A/C | intron_variant | |
rs1002850287 | -- | 143,988,529(+) | G/A | upstream_transcript_variant | |
rs1003404964 | -- | 143,988,715(+) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv12431n54 | CNV | loss | 21841781 |
dgv12432n54 | CNV | loss | 21841781 |
dgv12433n54 | CNV | gain | 21841781 |
dgv906n27 | CNV | loss | 19166990 |
nsv1075597 | CNV | deletion | 25765185 |
nsv1161815 | CNV | deletion | 26073780 |
nsv470249 | CNV | loss | 18288195 |
nsv470250 | CNV | gain | 18288195 |
nsv515809 | CNV | gain+loss | 19592680 |
nsv612906 | CNV | loss | 21841781 |
nsv612907 | CNV | gain+loss | 21841781 |
nsv612914 | CNV | loss | 21841781 |
nsv6445 | CNV | insertion | 18451855 |
nsv950015 | CNV | deletion | 24416366 |
Additional Variant Information for GRINA Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene
Disorders for GRINA Gene
Additional Disease Information for GRINA
No disorders were found for GRINA Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene
Publications for GRINA Gene
- Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C … Hayden MR (Genomics 1993) 2 3 4 22 58
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 58
- Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar KN … Michaelis EK (Nature 1991) 2 3 58
- Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation. (PMID: 26990286) Garcia-Quintanilla A … Miranzo-Navarro D (BioEssays : news and reviews in molecular, cellular and developmental biology 2016) 3 58
- The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state. (PMID: 25764978) Lisak DA … Methner A (Biochimica et biophysica acta 2015) 3 58
Products for GRINA Gene
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Sources for GRINA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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