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Aliases for GRINA Gene

Aliases for GRINA Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1 2 3 5
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3
  • Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
  • Transmembrane BAX Inhibitor Motif Containing 3 2 3
  • Glutamate [NMDA] Receptor-Associated Protein 1 3 4
  • NMDA Receptor Glutamate-Binding Subunit 3 4
  • Putative MAPK-Activating Protein PM02 3 4
  • NMDARA1 3 4
  • TMBIM3 3 4
  • LFG1 3 4
  • Glutamate Receptor, NMDA Subtype, Glutamate-Binding Subunit 3
  • Protein Lifeguard 1 3
  • HNRGW 3

External Ids for GRINA Gene

Previous HGNC Symbols for GRINA Gene


Previous GeneCards Identifiers for GRINA Gene

  • GC08U990038
  • GC08M145371
  • GC08P144839
  • GC08P145170
  • GC08P145171
  • GC08P145136
  • GC08P145064
  • GC08P140305

Summaries for GRINA Gene

GeneCards Summary for GRINA Gene

GRINA (Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1) is a Protein Coding gene. Among its related pathways are fMLP Pathway and Dopamine-DARPP32 Feedback onto cAMP Pathway. GO annotations related to this gene include ion channel binding. An important paralog of this gene is TMBIM1.

UniProtKB/Swiss-Prot for GRINA Gene

  • Potential apoptotic regulator.

Additional gene information for GRINA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene

Genomics for GRINA Gene

Regulatory Elements for GRINA Gene

Enhancers for GRINA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 4.1 -52.9 -52928 45.2 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 EEF1D ZNF623 CPSF1 VPS28
GH08H144014 1.5 FANTOM5 Ensembl ENCODE 4.7 +24.8 24814 0.9 ZSCAN4 INSM2 KLF17 SIN3A ZEB1 ZNF155 GLIS2 ZNF366 SCRT2 FOS ZNF7 ZNF250 ZNF623 ZNF251 VPS28 GPAA1 AK3P2 ZNF16 SPATC1 CPSF1
GH08H143430 1.3 ENCODE dbSUPER 5.1 -559.0 -558977 1.6 PKNOX1 ARID4B SIN3A ZNF2 GLIS2 CBX5 ZNF207 ZNF143 ATF7 RUNX3 ZNF623 JRK VPS28 CPSF1 MAFA LOC105375798 GSDMD ZNF696 GRINA PIR44330
GH08H144011 1.4 FANTOM5 Ensembl ENCODE 3.9 +22.5 22479 2.3 HDGF TBL1XR1 RELA FOSL1 ZNF316 POLR2A EED ATF7 ETV6 RUNX3 PLEC SPATC1 ENSG00000255224 GRINA PARP10
GH08H143544 1.7 FANTOM5 Ensembl ENCODE 3.1 -442.9 -442947 6.2 HDGF PKNOX1 ARNT ARID4B YY1 ZNF766 CBX5 FOS SP5 JUNB ENSG00000254859 ZC3H3 GSDMD NAPRT TOP1MT GRINA SPATC1 PIR45502
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRINA on UCSC Golden Path with GeneCards custom track

Promoters for GRINA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232187 442 1801 HDAC1 TBL1XR1 RB1 ARID4B SIN3A RARA EGR1 ZNF143 ZNF207 IKZF2

Transcription factor binding sites by QIAGEN in the GRINA gene promoter:

Genomic Locations for GRINA Gene

Genomic Locations for GRINA Gene
3,362 bases
Plus strand

Genomic View for GRINA Gene

Genes around GRINA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRINA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRINA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRINA Gene

Proteins for GRINA Gene

  • Protein details for GRINA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 1
    Protein Accession:
    Secondary Accessions:
    • B3KXM7
    • O43836
    • Q8IVW7

    Protein attributes for GRINA Gene

    371 amino acids
    Molecular mass:
    41203 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};

neXtProt entry for GRINA Gene

Post-translational modifications for GRINA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRINA Gene

Domains & Families for GRINA Gene

Gene Families for GRINA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GRINA Gene


Suggested Antigen Peptide Sequences for GRINA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with GRINA: view

Function for GRINA Gene

Molecular function for GRINA Gene

GENATLAS Biochemistry:
N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit
UniProtKB/Swiss-Prot Function:
Potential apoptotic regulator.

Phenotypes From GWAS Catalog for GRINA Gene

Gene Ontology (GO) - Molecular Function for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IEA --
genes like me logo Genes that share ontologies with GRINA: view
genes like me logo Genes that share phenotypes with GRINA: view

Animal Models for GRINA Gene

MGI Knock Outs for GRINA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRINA Gene

Localization for GRINA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRINA gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRINA: view

Pathways & Interactions for GRINA Gene

genes like me logo Genes that share pathways with GRINA: view

Interacting Proteins for GRINA Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000314380 for GRINA Gene via STRING

Gene Ontology (GO) - Biological Process for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032469 endoplasmic reticulum calcium ion homeostasis IEA --
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with GRINA: view

No data available for SIGNOR curated interactions for GRINA Gene

Drugs & Compounds for GRINA Gene

No Compound Related Data Available

Transcripts for GRINA Gene

Unigene Clusters for GRINA Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRINA Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for GRINA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRINA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRINA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRINA Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for GRINA Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRINA Gene

Protein tissue co-expression partners for GRINA Gene

NURSA nuclear receptor signaling pathways regulating expression of GRINA Gene:


SOURCE GeneReport for Unigene cluster for GRINA Gene:


Evidence on tissue expression from TISSUES for GRINA Gene

  • Pancreas(4.8)
  • Lung(4.6)
  • Kidney(4.5)
  • Liver(4.5)
  • Nervous system(4.4)
  • Skin(3.4)
  • Eye(3)
  • Intestine(2.1)
  • Bone marrow(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with GRINA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRINA Gene

Orthologs for GRINA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRINA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRINA 33 34
  • 99.46 (n)
(Bos Taurus)
Mammalia GRINA 33 34
  • 91.17 (n)
(Canis familiaris)
Mammalia GRINA 33 34
  • 90.54 (n)
(Rattus norvegicus)
Mammalia Grina 33
  • 89.56 (n)
(Mus musculus)
Mammalia Grina 33 16 34
  • 87.73 (n)
(Monodelphis domestica)
Mammalia GRINA 34
  • 83 (a)
(Anolis carolinensis)
Reptilia GRINA 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1396 33
African clawed frog
(Xenopus laevis)
Amphibia grina-prov 33
(Danio rerio)
Actinopterygii zgc:136572 33
  • 68.41 (n)
  • 66 (a)
zgc64102 33
fruit fly
(Drosophila melanogaster)
Insecta Nmda1 33
  • 54.83 (n)
CG3814 34
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 34
  • 24 (a)
Species where no ortholog for GRINA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRINA Gene

Gene Tree for GRINA (if available)
Gene Tree for GRINA (if available)

Paralogs for GRINA Gene

Paralogs for GRINA Gene

(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GRINA: view

Variants for GRINA Gene

Sequence variations from dbSNP and Humsavar for GRINA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000602570 -- 143,990,929(+) GCCCC(A/G)AATCC intron-variant
rs1001264450 -- 143,993,141(+) CCAGG(G/T)ACTGG utr-variant-3-prime
rs1002271584 -- 143,992,192(+) CCGGC(A/C)GGGGT intron-variant
rs1002850287 -- 143,988,529(+) GGCAC(A/G)ATCTC upstream-variant-2KB
rs1003404964 -- 143,988,715(+) CACCC(A/G)CCTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GRINA Gene

Variant ID Type Subtype PubMed ID
nsv950015 CNV deletion 24416366
nsv6445 CNV insertion 18451855
nsv612914 CNV loss 21841781
nsv612907 CNV gain+loss 21841781
nsv612906 CNV loss 21841781
nsv515809 CNV gain+loss 19592680
nsv470250 CNV gain 18288195
nsv470249 CNV loss 18288195
nsv1161815 CNV deletion 26073780
nsv1075597 CNV deletion 25765185
dgv906n27 CNV loss 19166990
dgv12433n54 CNV gain 21841781
dgv12432n54 CNV loss 21841781
dgv12431n54 CNV loss 21841781

Variation tolerance for GRINA Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRINA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene

Disorders for GRINA Gene

Relevant External Links for GRINA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRINA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene

Publications for GRINA Gene

  1. Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C … Hayden MR (Genomics 1993) 2 3 4 22 60
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 60
  3. Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar KN … Michaelis EK (Nature 1991) 2 3 60
  4. Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation. (PMID: 26990286) Garcia-Quintanilla A … Miranzo-Navarro D (BioEssays : news and reviews in molecular, cellular and developmental biology 2016) 3 60
  5. The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state. (PMID: 25764978) Lisak DA … Methner A (Biochimica et biophysica acta 2015) 3 60

Products for GRINA Gene

Sources for GRINA Gene

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