Aliases for GRINA Gene
Aliases for GRINA Gene
- Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1 2 3 5
- Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3
- Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
- Transmembrane BAX Inhibitor Motif Containing 3 2 3
- Glutamate [NMDA] Receptor-Associated Protein 1 3 4
- NMDA Receptor Glutamate-Binding Subunit 3 4
- Putative MAPK-Activating Protein PM02 3 4
External Ids for GRINA Gene
- HGNC: 4589
- Entrez Gene: 2907
- Ensembl: ENSG00000178719
- OMIM: 138251
- UniProtKB: Q7Z429
Previous HGNC Symbols for GRINA Gene
- NMDARA1
Previous GeneCards Identifiers for GRINA Gene
- GC08U990038
- GC08M145371
- GC08P144839
- GC08P145170
- GC08P145171
- GC08P145136
- GC08P145064
- GC08P140305
Summaries for GRINA Gene
GeneCards Summary for GRINA Gene
GRINA (Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1) is a Protein Coding gene. Among its related pathways are Amyotrophic lateral sclerosis (ALS) and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is TMBIM1.
UniProtKB/Swiss-Prot for GRINA Gene
-
Potential apoptotic regulator.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene
Genomics for GRINA Gene
GeneHancer (GH) Regulatory Elements for GRINA Gene
Promoters and enhancers for GRINA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GRINA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GRINA Gene
Genomic Locations for GRINA Gene
- chr8:143,990,058-143,993,419
- (GRCh38/hg38)
- Size:
- 3,362 bases
- Orientation:
- Plus strand
- chr8:145,064,226-145,067,583
- (GRCh37/hg19)
Genomic View for GRINA Gene
Genes around GRINA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
GRINA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRINA Gene
Proteins for GRINA Gene
-
Protein details for GRINA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z429-LFG1_HUMAN
- Recommended name:
- Protein lifeguard 1
- Protein Accession:
- Q7Z429
- B3KXM7
- O43836
- Q8IVW7
Protein attributes for GRINA Gene
- Size:
- 371 amino acids
- Molecular mass:
- 41203 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};
Protein Expression for GRINA Gene
Post-translational modifications for GRINA Gene
No Post-translational modifications
Other Protein References for GRINA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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Protein Products
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Assay Products
- antibodies-online: Search results for 8 available GRINA Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for GRINA Gene
Domains & Families for GRINA Gene
Gene Families for GRINA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GRINA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRINA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z429- Family:
-
- Belongs to the BI1 family. LFG subfamily.
Function for GRINA Gene
Molecular function for GRINA Gene
- GENATLAS Biochemistry:
- N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit
- UniProtKB/Swiss-Prot Function:
- Potential apoptotic regulator.
Phenotypes From GWAS Catalog for GRINA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0044325 | ion channel binding | IEA | -- |
Phenotypes for GRINA Gene
- MGI mutant phenotypes for GRINA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRINA:
-
- Increased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Salmonella enterica Typhimurium invasion
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
Animal Models for GRINA Gene
- MGI Knock Outs for GRINA:
-
- Grina tm1.1Ldh
Animal Model Products
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-
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CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
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- GenScript: Design CRISPR guide RNA sequences for GRINA
miRNA for GRINA Gene
- miRTarBase miRNAs that target GRINA
-
- hsa-mir-7-5p (MIRT025808)
- hsa-mir-296-3p (MIRT038514)
- hsa-mir-106b-3p (MIRT038571)
- hsa-mir-125b-5p (MIRT046002)
- hsa-mir-34a-5p (MIRT047387)
- hsa-mir-10b-5p (MIRT047457)
- hsa-mir-3127-5p (MIRT476056)
- hsa-mir-4290 (MIRT476057)
- hsa-mir-4518 (MIRT476058)
- hsa-mir-6859-3p (MIRT476059)
- hsa-mir-1266-5p (MIRT476060)
- hsa-mir-3918 (MIRT476061)
- hsa-mir-383-3p (MIRT476062)
- hsa-mir-3065-3p (MIRT476063)
- hsa-mir-548ao-3p (MIRT476064)
- hsa-mir-3667-5p (MIRT476065)
- hsa-mir-24-3p (MIRT476066)
- hsa-mir-4665-5p (MIRT489757)
- hsa-mir-1275 (MIRT489758)
- hsa-mir-4472 (MIRT489759)
- hsa-mir-4447 (MIRT489760)
- hsa-mir-92a-2-5p (MIRT489761)
- hsa-mir-5010-5p (MIRT489762)
- hsa-mir-4525 (MIRT489763)
- hsa-mir-6870-5p (MIRT489764)
- hsa-mir-7111-5p (MIRT489765)
- hsa-mir-5698 (MIRT489766)
- hsa-mir-4723-5p (MIRT489767)
- hsa-mir-625-5p (MIRT489768)
- hsa-mir-6825-5p (MIRT489769)
- hsa-mir-939-5p (MIRT489770)
- hsa-mir-1343-5p (MIRT489771)
- hsa-mir-6780b-5p (MIRT489772)
- hsa-mir-4725-3p (MIRT489773)
- hsa-mir-4271 (MIRT489774)
- hsa-mir-6799-5p (MIRT489775)
- hsa-mir-6827-5p (MIRT489776)
- hsa-mir-4747-5p (MIRT489777)
- hsa-mir-5196-5p (MIRT489778)
- hsa-mir-6851-5p (MIRT489779)
- hsa-mir-3689d (MIRT489780)
- hsa-mir-3202 (MIRT489781)
- hsa-mir-6134 (MIRT489782)
- hsa-mir-3179 (MIRT489783)
- hsa-mir-6794-5p (MIRT489784)
- hsa-mir-4716-3p (MIRT489785)
miRNA Products
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Clone Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRINA Gene
Localization for GRINA Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| endoplasmic reticulum | 3 |
| golgi apparatus | 3 |
| lysosome | 1 |
- Cytosol (2)
- Nucleoli fibrillar center (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GRINA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
| 2 | fMLP Pathway | ||
| 3 | CREB Pathway | ||
| 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | ||
| 5 | nNOS Signaling at Neuronal Synapses | ||
Pathways by source for GRINA Gene
Interacting Proteins for GRINA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032469 | endoplasmic reticulum calcium ion homeostasis | IEA | -- |
| GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | IEA | -- |
No data available for SIGNOR curated interactions for GRINA Gene
Transcripts for GRINA Gene
mRNA/cDNA for GRINA Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (475) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GRINA Gene
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRINA
- GenScript: Design CRISPR guide RNA sequences for GRINA
miRNA Products
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Inhibitory RNA Products
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Clone Products
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- Applied Biological Materials Clones for GRINA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: |
Expression for GRINA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for GRINA Gene
This gene is overexpressed in Whole Blood (x7.1).
This gene is overexpressed in Urine (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRINA Gene
NURSA nuclear receptor signaling pathways regulating expression of GRINA Gene:
GRINASOURCE GeneReport for Unigene cluster for GRINA Gene:
Hs.594634Evidence on tissue expression from TISSUES for GRINA Gene
- Pancreas(4.8)
- Lung(4.6)
- Kidney(4.5)
- Liver(4.5)
- Nervous system(4.4)
- Skin(3.4)
- Eye(3)
- Intestine(2.1)
- Bone marrow(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for GRINA
- genomics-online: primer clones - Search results for available GRINA gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRINA Gene
Orthologs for GRINA Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRINA 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GRINA 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GRINA 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Grina 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Grina 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GRINA 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GRINA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1396 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | grina-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:136572 33 |
|
||
| GRINA 34 |
|
OneToOne | |||
| zgc64102 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Nmda1 33 |
|
||
| CG3814 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BXI1 34 |
|
OneToMany |
- Species where no ortholog for GRINA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GRINA Gene
(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:
Variants for GRINA Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000602570 | -- | 143,990,929(+) | A/G | intron_variant | |
| rs1001264450 | -- | 143,993,141(+) | G/T | 3_prime_UTR_variant | |
| rs1002271584 | -- | 143,992,192(+) | A/C | intron_variant | |
| rs1002850287 | -- | 143,988,529(+) | G/A | upstream_transcript_variant | |
| rs1003404964 | -- | 143,988,715(+) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12431n54 | CNV | loss | 21841781 |
| dgv12432n54 | CNV | loss | 21841781 |
| dgv12433n54 | CNV | gain | 21841781 |
| dgv906n27 | CNV | loss | 19166990 |
| nsv1075597 | CNV | deletion | 25765185 |
| nsv1161815 | CNV | deletion | 26073780 |
| nsv470249 | CNV | loss | 18288195 |
| nsv470250 | CNV | gain | 18288195 |
| nsv515809 | CNV | gain+loss | 19592680 |
| nsv612906 | CNV | loss | 21841781 |
| nsv612907 | CNV | gain+loss | 21841781 |
| nsv612914 | CNV | loss | 21841781 |
| nsv6445 | CNV | insertion | 18451855 |
| nsv950015 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.54;
11.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRINA Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene
Disorders for GRINA Gene
Additional Disease Information for GRINA
No disorders were found for GRINA Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene
Publications for GRINA Gene
- Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C … Hayden MR (Genomics 1993) 2 3 4 22 58
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 58
- Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar KN … Michaelis EK (Nature 1991) 2 3 58
- Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation. (PMID: 26990286) Garcia-Quintanilla A … Miranzo-Navarro D (BioEssays : news and reviews in molecular, cellular and developmental biology 2016) 3 58
- The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state. (PMID: 25764978) Lisak DA … Methner A (Biochimica et biophysica acta 2015) 3 58
Products for GRINA Gene
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Sources for GRINA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew