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Aliases for GRINA Gene

Aliases for GRINA Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1 2 3 5
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3
  • Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
  • Transmembrane BAX Inhibitor Motif Containing 3 2 3
  • Glutamate [NMDA] Receptor-Associated Protein 1 3 4
  • NMDA Receptor Glutamate-Binding Subunit 3 4
  • Putative MAPK-Activating Protein PM02 3 4
  • NMDARA1 3 4
  • TMBIM3 3 4
  • LFG1 3 4
  • Glutamate Receptor, NMDA Subtype, Glutamate-Binding Subunit 3
  • Protein Lifeguard 1 3
  • HNRGW 3

External Ids for GRINA Gene

Previous HGNC Symbols for GRINA Gene


Previous GeneCards Identifiers for GRINA Gene

  • GC08U990038
  • GC08M145371
  • GC08P144839
  • GC08P145170
  • GC08P145171
  • GC08P145136
  • GC08P145064
  • GC08P140305

Summaries for GRINA Gene

GeneCards Summary for GRINA Gene

GRINA (Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1) is a Protein Coding gene. Among its related pathways are Amyotrophic lateral sclerosis (ALS) and fMLP Pathway. GO annotations related to this gene include ion channel binding. An important paralog of this gene is MIR6513.

UniProtKB/Swiss-Prot for GRINA Gene

  • Potential apoptotic regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene

Genomics for GRINA Gene

Regulatory Elements for GRINA Gene

Enhancers for GRINA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F143430 0.5 ENCODE 5.1 -559.0 -558977 1.6 PKNOX1 ARID4B SIN3A ZNF2 GLIS2 ZNF207 ZNF143 SP3 SP5 NFYC ZNF696 MAFA LOC105375798 GSDMD GRINA PIR44330
GH08F144011 1.3 FANTOM5 Ensembl ENCODE 4.7 +23.3 23314 3.9 HDGF TBL1XR1 INSM2 KLF17 SIN3A ZEB1 ZNF155 GLIS2 ZNF366 SCRT2 PLEC SPATC1 ZNF250 ZNF623 VPS28 GPAA1 COMMD5 SLC52A2 ZNF251 ADCK5
GH08F143792 1.3 Ensembl ENCODE 4.6 -196.5 -196482 2.0 HDGF CTCF HIC1 GLIS2 ZFHX2 ZBTB33 FOS EGR2 PUF60 FAM83H GRINA SCRIB ENSG00000254973 MIR937
GH08F143914 1.3 FANTOM5 Ensembl ENCODE 4.1 -52.9 -52928 45.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF251 ZNF250 ZNF517 LRRC14 PLEC LOC105375803 ZNF696 ZNF623 VPS28 COMMD5
GH08F144007 1.2 FANTOM5 Ensembl 3.1 +18.8 18843 2.2 CTCF SAP130 JUN RAD21 ZIC2 RARA ZNF316 NFE2 MAFK EGR2 PLEC SPATC1 ENSG00000255224 GRINA
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GRINA on UCSC Golden Path with GeneCards custom track

Promoters for GRINA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404346 442 2201 HDAC1 TBL1XR1 ARID4B SIN3A ZNF48 ZBTB40 RARA EGR1 SP3 SP5

Genomic Location for GRINA Gene

143,990,058 bp from pter
143,993,419 bp from pter
3,362 bases
Plus strand

Genomic View for GRINA Gene

Genes around GRINA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRINA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRINA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRINA Gene

Proteins for GRINA Gene

  • Protein details for GRINA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 1
    Protein Accession:
    Secondary Accessions:
    • B3KXM7
    • O43836
    • Q8IVW7

    Protein attributes for GRINA Gene

    371 amino acids
    Molecular mass:
    41203 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};

neXtProt entry for GRINA Gene

Post-translational modifications for GRINA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRINA Gene

Domains & Families for GRINA Gene

Gene Families for GRINA Gene

Protein Domains for GRINA Gene


Suggested Antigen Peptide Sequences for GRINA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with GRINA: view

Function for GRINA Gene

Molecular function for GRINA Gene

GENATLAS Biochemistry:
N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit
UniProtKB/Swiss-Prot Function:
Potential apoptotic regulator.

Gene Ontology (GO) - Molecular Function for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IEA --
genes like me logo Genes that share ontologies with GRINA: view
genes like me logo Genes that share phenotypes with GRINA: view

Animal Models for GRINA Gene

MGI Knock Outs for GRINA:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRINA Gene

Localization for GRINA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRINA Gene COMPARTMENTS Subcellular localization image for GRINA gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRINA: view

Pathways & Interactions for GRINA Gene

genes like me logo Genes that share pathways with GRINA: view

Interacting Proteins for GRINA Gene

Gene Ontology (GO) - Biological Process for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032469 endoplasmic reticulum calcium ion homeostasis IEA --
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with GRINA: view

No data available for SIGNOR curated interactions for GRINA Gene

Transcripts for GRINA Gene

Unigene Clusters for GRINA Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRINA Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for GRINA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRINA Gene

mRNA expression in normal human tissues for GRINA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRINA Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for GRINA Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRINA Gene

Protein tissue co-expression partners for GRINA Gene

NURSA nuclear receptor signaling pathways regulating expression of GRINA Gene:


SOURCE GeneReport for Unigene cluster for GRINA Gene:

genes like me logo Genes that share expression patterns with GRINA: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GRINA Gene

Orthologs for GRINA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRINA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRINA 34 35
  • 99.46 (n)
(Bos Taurus)
Mammalia GRINA 34 35
  • 91.17 (n)
(Canis familiaris)
Mammalia GRINA 34 35
  • 90.54 (n)
(Rattus norvegicus)
Mammalia Grina 34
  • 89.56 (n)
(Mus musculus)
Mammalia Grina 34 16 35
  • 87.73 (n)
(Monodelphis domestica)
Mammalia GRINA 35
  • 83 (a)
(Anolis carolinensis)
Reptilia GRINA 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1396 34
African clawed frog
(Xenopus laevis)
Amphibia grina-prov 34
(Danio rerio)
Actinopterygii zgc:136572 34
  • 68.41 (n)
  • 66 (a)
zgc64102 34
fruit fly
(Drosophila melanogaster)
Insecta Nmda1 34
  • 54.83 (n)
CG3814 35
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 35
  • 24 (a)
Species where no ortholog for GRINA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRINA Gene

Gene Tree for GRINA (if available)
Gene Tree for GRINA (if available)

Paralogs for GRINA Gene

Paralogs for GRINA Gene

(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GRINA: view

Variants for GRINA Gene

Sequence variations from dbSNP and Humsavar for GRINA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs112357076 -- 143,991,015(+) GGCGC(C/T)GCCCG intron-variant
rs113143709 -- 143,991,197(+) TTCTC(C/T)AGGGG intron-variant
rs114570898 -- 143,993,701(+) ATAGC(C/T)GCCTC downstream-variant-500B
rs115144422 -- 143,989,490(+) AAAAT(G/T)CCTGA upstream-variant-2KB
rs115289032 -- 143,991,828(+) AAGGC(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRINA Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv12432n54 CNV loss 21841781
dgv12433n54 CNV gain 21841781
dgv906n27 CNV loss 19166990
nsv1075597 CNV deletion 25765185
nsv1161815 CNV deletion 26073780
nsv470249 CNV loss 18288195
nsv470250 CNV gain 18288195
nsv515809 CNV gain+loss 19592680
nsv612906 CNV loss 21841781
nsv612907 CNV gain+loss 21841781
nsv612914 CNV loss 21841781
nsv6445 CNV insertion 18451855
nsv950015 CNV deletion 24416366

Variation tolerance for GRINA Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRINA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene

Disorders for GRINA Gene

Relevant External Links for GRINA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GRINA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene

Publications for GRINA Gene

  1. Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C. … Hayden M.R. (Genomics 1993) 2 3 4 22 64
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4 64
  3. Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar K.N. … Michaelis E.K. (Nature 1991) 2 3 64
  4. The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CAA^a8_-filling state. (PMID: 25764978) Lisak D.A. … Methner A. (Biochim. Biophys. Acta 2015) 3 64
  5. Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures. (PMID: 23267846) Shin A.H. … Thayer S.A. (Mol. Cell. Neurosci. 2013) 3 64

Products for GRINA Gene

Sources for GRINA Gene

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