Aliases for GRINA Gene
Aliases for GRINA Gene
- Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1 2 3
- Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3 5
- Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
- Transmembrane BAX Inhibitor Motif Containing 3 2 3
- Glutamate [NMDA] Receptor-Associated Protein 1 3 4
- NMDA Receptor Glutamate-Binding Subunit 3 4
- Putative MAPK-Activating Protein PM02 3 4
External Ids for GRINA Gene
- HGNC: 4589
- Entrez Gene: 2907
- Ensembl: ENSG00000178719
- OMIM: 138251
- UniProtKB: Q7Z429
Previous HGNC Symbols for GRINA Gene
- NMDARA1
Previous GeneCards Identifiers for GRINA Gene
- GC08U990038
- GC08M145371
- GC08P144839
- GC08P145170
- GC08P145171
- GC08P145136
- GC08P145064
- GC08P140305
Summaries for GRINA Gene
GeneCards Summary for GRINA Gene
GRINA (Glutamate Ionotropic Receptor NMDA Type Subunit Associated Protein 1) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and nNOS Signaling at Neuronal Synapses. GO annotations related to this gene include ion channel binding. An important paralog of this gene is FAIM2.
UniProtKB/Swiss-Prot for GRINA Gene
-
Potential apoptotic regulator.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene
Genomics for GRINA Gene
Regulatory Elements for GRINA Gene
Enhancers for GRINA Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around GRINA on UCSC Golden Path with GeneCards custom track
Promoters for GRINA Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around GRINA on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the GRINA gene promoter:
Regulatory Element Products
Genomic Location for GRINA Gene
- Chromosome:
- 8
- Start:
- 143,990,058 bp from pter
- End:
- 143,993,419 bp from pter
- Size:
- 3,362 bases
- Orientation:
- Plus strand
Genomic View for GRINA Gene
Genes around GRINA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
GRINA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRINA Gene
Proteins for GRINA Gene
-
Protein details for GRINA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z429-LFG1_HUMAN
- Recommended name:
- Protein lifeguard 1
- Protein Accession:
- Q7Z429
- B3KXM7
- O43836
- Q8IVW7
Protein attributes for GRINA Gene
- Size:
- 371 amino acids
- Molecular mass:
- 41203 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};
Protein Expression for GRINA Gene
Post-translational modifications for GRINA Gene
Other Protein References for GRINA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GRINA
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- Invitrogen Antibodies for GRINA
- antibodies-online Antibodies for GRINA: See all 55
- GeneTex GRINA antibody for GRINA
-
Custom Antibody ServicesProSci Antibodies for GRINA
Protein Products
-
OriGene Purified Proteins for GRINA
- Search Origene for MassSpec and Protein Over-expression Lysates for GRINA
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- Search GeneTex for Proteins for GRINA
Assay Products
- antibodies-online Kits for GRINA: See all 4
No data available for DME Specific Peptides for GRINA Gene
Domains & Families for GRINA Gene
Gene Families for GRINA Gene
Protein Domains for GRINA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRINA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z429- Family:
-
- Belongs to the BI1 family. LFG subfamily.
Function for GRINA Gene
Molecular function for GRINA Gene
- GENATLAS Biochemistry:
- N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit
- UniProtKB/Swiss-Prot Function:
- Potential apoptotic regulator.
Phenotypes for GRINA Gene
- MGI mutant phenotypes for GRINA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRINA:
Animal Models for GRINA Gene
- MGI Knock Outs for GRINA:
-
- Grina tm1.1Ldh
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for GRINA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GRINA gene
- Search ViGene Biosciences for GRINA
CRISPR Products
-
OriGene CRISPR knockouts for GRINA
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRINA
- GenScript: Design CRISPR guide RNA sequences for GRINA
miRNA for GRINA Gene
- miRTarBase miRNAs that target GRINA
-
- hsa-mir-7-5p (MIRT025808)
- hsa-mir-296-3p (MIRT038514)
- hsa-mir-106b-3p (MIRT038571)
- hsa-mir-125b-5p (MIRT046002)
- hsa-mir-34a-5p (MIRT047387)
- hsa-mir-10b-5p (MIRT047457)
- hsa-mir-3127-5p (MIRT476056)
- hsa-mir-4290 (MIRT476057)
- hsa-mir-4518 (MIRT476058)
- hsa-mir-6859-3p (MIRT476059)
- hsa-mir-1266-5p (MIRT476060)
- hsa-mir-3918 (MIRT476061)
- hsa-mir-383-3p (MIRT476062)
- hsa-mir-3065-3p (MIRT476063)
- hsa-mir-548ao-3p (MIRT476064)
- hsa-mir-3667-5p (MIRT476065)
- hsa-mir-24-3p (MIRT476066)
- hsa-mir-4665-5p (MIRT489757)
- hsa-mir-1275 (MIRT489758)
- hsa-mir-4472 (MIRT489759)
- hsa-mir-4447 (MIRT489760)
- hsa-mir-92a-2-5p (MIRT489761)
- hsa-mir-5010-5p (MIRT489762)
- hsa-mir-4525 (MIRT489763)
- hsa-mir-6870-5p (MIRT489764)
- hsa-mir-7111-5p (MIRT489765)
- hsa-mir-5698 (MIRT489766)
- hsa-mir-4723-5p (MIRT489767)
- hsa-mir-625-5p (MIRT489768)
- hsa-mir-6825-5p (MIRT489769)
- hsa-mir-939-5p (MIRT489770)
- hsa-mir-1343-5p (MIRT489771)
- hsa-mir-6780b-5p (MIRT489772)
- hsa-mir-4725-3p (MIRT489773)
- hsa-mir-4271 (MIRT489774)
- hsa-mir-6799-5p (MIRT489775)
- hsa-mir-6827-5p (MIRT489776)
- hsa-mir-4747-5p (MIRT489777)
- hsa-mir-5196-5p (MIRT489778)
- hsa-mir-6851-5p (MIRT489779)
- hsa-mir-3689d (MIRT489780)
- hsa-mir-3202 (MIRT489781)
- hsa-mir-6134 (MIRT489782)
- hsa-mir-3179 (MIRT489783)
- hsa-mir-6794-5p (MIRT489784)
- hsa-mir-4716-3p (MIRT489785)
miRNA Products
- Search ViGene Biosciences for GRINA
Clone Products
- OriGene clones in human for GRINA
- OriGene ORF clones in human,mouse,rat for GRINA
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GRINA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GRINA gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRINA Gene
Localization for GRINA Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 3 |
| golgi apparatus | 3 |
| plasma membrane | 3 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for GRINA Gene
More details on SuperPathways for GRINA| Superpath | Contained pathways | |
|---|---|---|
| 1 | Dopamine-DARPP32 Feedback onto cAMP Pathway | |
| 2 | fMLP Pathway | |
| 3 | CREB Pathway | |
| 4 | Neuropathic Pain-Signaling in Dorsal Horn Neurons | |
| 5 | nNOS Signaling at Neuronal Synapses |
Pathways by source for GRINA Gene
Interacting Proteins for GRINA Gene
No data available for SIGNOR curated interactions for GRINA Gene
Transcripts for GRINA Gene
mRNA/cDNA for GRINA Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (475) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GRINA Gene
CRISPR Products
-
OriGene CRISPR knockouts for GRINA
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRINA
- GenScript: Design CRISPR guide RNA sequences for GRINA
miRNA Products
- Search ViGene Biosciences for GRINA
Clone Products
- OriGene clones in human for GRINA
- OriGene ORF clones in human,mouse,rat for GRINA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRINA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: |
Expression for GRINA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for GRINA Gene
This gene is overexpressed in Whole Blood (x7.1).
This gene is overexpressed in Urine (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRINA Gene
SOURCE GeneReport for Unigene cluster for GRINA Gene Hs.594634
Primer Products
-
OriGene qPCR primer pairs for GRINA
No data available for mRNA Expression by UniProt/SwissProt for GRINA Gene
Orthologs for GRINA Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | GRINA 35 |
|
||
| GRINA 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | GRINA 35 |
|
||
| GRINA 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Grina 35 |
|
||
| Grina 16 |
|
||||
| Grina 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | GRINA 35 |
|
||
| GRINA 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Grina 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GRINA 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GRINA 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1396 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | grina-prov 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc64102 35 |
|
||
| zgc:136572 35 |
|
||||
| GRINA 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Nmda1 35 |
|
||
| CG3814 36 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BXI1 36 |
|
OneToMany |
- Species with no ortholog for GRINA:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GRINA Gene
Paralogs for GRINA Gene
(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:
Variants for GRINA Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17854152 | - | 143,991,543(+) | CCAGA(A/G/T)CCCCT | reference, missense | |
| rs3211273 | -- | 143,992,273(-) | CCACC(A/G)TGTAC | reference, missense | |
| rs3211274 | -- | 143,991,959(-) | GACAA(A/G)GCCCT | reference, missense | |
| rs3211275 | -- | 143,991,892(-) | AAGGT(C/T)AGCAC | reference, synonymous-codon | |
| rs11548883 | -- | 143,992,347(-) | GGTGA(A/G)GCAGA | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7935n71 | CNV | Loss | 21882294 |
| dgv7940n71 | CNV | Loss | 21882294 |
| dgv7943n71 | CNV | Loss | 21882294 |
| nsv891766 | CNV | Loss | 21882294 |
| dgv906n27 | CNV | Loss | 19166990 |
| nsv470249 | CNV | Loss | 18288195 |
| dgv7947n71 | CNV | Loss | 21882294 |
| dgv7948n71 | CNV | Loss | 21882294 |
| dgv7949n71 | CNV | Loss | 21882294 |
| dgv7950n71 | CNV | Loss | 21882294 |
| dgv7951n71 | CNV | Gain+Loss | 21882294 |
| nsv891787 | CNV | Gain+Loss | 21882294 |
| nsv515809 | CNV | Gain+Loss | 19592680 |
| nsv470250 | CNV | Gain | 18288195 |
| nsv6445 | CNV | Insertion | 18451855 |
Residual Variation Intolerance Score:
48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.54;
11.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for GRINA Gene
- Human Gene Mutation Database (HGMD)
- GRINA
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene
Disorders for GRINA Gene
Relevant External Links for GRINA
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- GRINA
No disorders were found for GRINA Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene
Publications for GRINA Gene
- Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C. … Hayden M.R. (Genomics 1993) 2 3 4 23 67
- Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar K.N. … Michaelis E.K. (Nature 1991) 2 3
- The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CAA^a8_-filling state. (PMID: 25764978) Lisak D.A. … Methner A. (Biochim. Biophys. Acta 2015) 3
- Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures. (PMID: 23267846) Shin A.H. … Thayer S.A. (Mol. Cell. Neurosci. 2013) 3
- Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure. (PMID: 24086760) Shepherd A.J. … Mohapatra D.P. (PLoS ONE 2013) 3
Products for GRINA Gene
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- Custom Antibody ServicesOriGene Antibodies for GRINA
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- antibodies-online Antibodies for GRINA: See all 55
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- Search antibodies-online for proteins
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- ViGene Biosciences adenoviral particle packaged cDNA for GRINA gene
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Sources for GRINA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
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