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Aliases for GRINA Gene

Aliases for GRINA Gene

  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding) 2 3
  • Transmembrane BAX Inhibitor Motif-Containing Protein 3 3 4
  • Transmembrane BAX Inhibitor Motif Containing 3 2 3
  • Glutamate [NMDA] Receptor-Associated Protein 1 3 4
  • NMDA Receptor Glutamate-Binding Subunit 3 4
  • Putative MAPK-Activating Protein PM02 3 4
  • NMDARA1 3 4
  • TMBIM3 3 4
  • LFG1 3 4
  • Glutamate Receptor, NMDA Subtype, Glutamate-Binding Subunit 3
  • HNRGW 3

External Ids for GRINA Gene

Previous HGNC Symbols for GRINA Gene

  • NMDARA1

Previous GeneCards Identifiers for GRINA Gene

  • GC08U990038
  • GC08M145371
  • GC08P144839
  • GC08P145170
  • GC08P145171
  • GC08P145136
  • GC08P145064
  • GC08P140305

Summaries for GRINA Gene

GeneCards Summary for GRINA Gene

GRINA (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate-Associated Protein 1 (Glutamate Binding)) is a Protein Coding gene. Among its related pathways are CREB Pathway and fMLP Pathway. GO annotations related to this gene include ion channel binding. An important paralog of this gene is FAIM2.

UniProtKB/Swiss-Prot for GRINA Gene

  • Potential apoptotic regulator

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRINA Gene

Genomics for GRINA Gene

Regulatory Elements for GRINA Gene

Transcription factor binding sites by QIAGEN in the GRINA gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRINA Gene

Chromosome:
8
Start:
143,990,058 bp from pter
End:
143,993,419 bp from pter
Size:
3,362 bases
Orientation:
Plus strand

Genomic View for GRINA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRINA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRINA Gene

Proteins for GRINA Gene

  • Protein details for GRINA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z429-LFG1_HUMAN
    Recommended name:
    Protein lifeguard 1
    Protein Accession:
    Q7Z429
    Secondary Accessions:
    • B3KXM7
    • O43836
    • Q8IVW7

    Protein attributes for GRINA Gene

    Size:
    371 amino acids
    Molecular mass:
    41203 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB94292.1; Type=Frameshift; Positions=224, 371; Evidence={ECO:0000305};

neXtProt entry for GRINA Gene

Proteomics data for GRINA Gene at MOPED

Post-translational modifications for GRINA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRINA Gene

Domains & Families for GRINA Gene

Protein Domains for GRINA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRINA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z429

UniProtKB/Swiss-Prot:

LFG1_HUMAN :
  • Belongs to the BI1 family. LFG subfamily.
Family:
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with GRINA: view

No data available for Gene Families for GRINA Gene

Function for GRINA Gene

Molecular function for GRINA Gene

GENATLAS Biochemistry:
N-methyl D-aspartate receptor,glutamate receptor,glutamate binding subunit
UniProtKB/Swiss-Prot Function:
Potential apoptotic regulator

Gene Ontology (GO) - Molecular Function for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IEA --
genes like me logo Genes that share ontologies with GRINA: view
genes like me logo Genes that share phenotypes with GRINA: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRINA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GRINA Gene

Localization for GRINA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRINA Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRINA Gene COMPARTMENTS Subcellular localization image for GRINA gene
Compartment Confidence
endoplasmic reticulum 2
golgi apparatus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GRINA: view

Pathways & Interactions for GRINA Gene

genes like me logo Genes that share pathways with GRINA: view

Interacting Proteins for GRINA Gene

Gene Ontology (GO) - Biological Process for GRINA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032469 endoplasmic reticulum calcium ion homeostasis IEA --
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with GRINA: view

No data available for SIGNOR curated interactions for GRINA Gene

Drugs & Compounds for GRINA Gene

No Compound Related Data Available

Transcripts for GRINA Gene

Unigene Clusters for GRINA Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRINA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRINA Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GRINA Gene

GeneLoc Exon Structure for
GRINA
ECgene alternative splicing isoforms for
GRINA

Expression for GRINA Gene

mRNA expression in normal human tissues for GRINA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRINA Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for GRINA Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRINA Gene



SOURCE GeneReport for Unigene cluster for GRINA Gene Hs.594634

genes like me logo Genes that share expression patterns with GRINA: view

Protein tissue co-expression partners for GRINA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRINA Gene

Orthologs for GRINA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GRINA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRINA 35
  • 91.17 (n)
  • 92.62 (a)
GRINA 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRINA 35
  • 90.54 (n)
  • 95.22 (a)
GRINA 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grina 35
  • 87.73 (n)
  • 92.17 (a)
Grina 16
Grina 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRINA 35
  • 99.46 (n)
  • 98.92 (a)
GRINA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grina 35
  • 89.56 (n)
  • 94.25 (a)
oppossum
(Monodelphis domestica)
Mammalia GRINA 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRINA 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1396 35
African clawed frog
(Xenopus laevis)
Amphibia grina-prov 35
zebrafish
(Danio rerio)
Actinopterygii zgc64102 35
zgc:136572 35
  • 68.41 (n)
  • 70.15 (a)
GRINA 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nmda1 35
  • 54.83 (n)
  • 50.16 (a)
CG3814 36
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 36
  • 24 (a)
OneToMany
Species with no ortholog for GRINA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRINA Gene

ENSEMBL:
Gene Tree for GRINA (if available)
TreeFam:
Gene Tree for GRINA (if available)

Paralogs for GRINA Gene

Paralogs for GRINA Gene

(4) SIMAP similar genes for GRINA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GRINA: view

Variants for GRINA Gene

Sequence variations from dbSNP and Humsavar for GRINA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs9100 -- 143,993,299(-) TAAGA(A/C)CCCCA utr-variant-3-prime
rs7000180 -- 143,993,894(+) CGTCC(A/G)AGAGC downstream-variant-500B
rs7814596 -- 143,991,412(+) AGCCC(C/T)TACCC reference, synonymous-codon
rs11783599 -- 143,990,253(+) GCGGC(A/C)TGccg utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs13248856 -- 143,990,222(+) GCCCA(A/G)GAGCG utr-variant-5-prime, intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GRINA Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
dgv7943n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv906n27 CNV Loss 19166990
nsv470249 CNV Loss 18288195
dgv7947n71 CNV Loss 21882294
dgv7948n71 CNV Loss 21882294
dgv7949n71 CNV Loss 21882294
dgv7950n71 CNV Loss 21882294
dgv7951n71 CNV Gain+Loss 21882294
nsv891787 CNV Gain+Loss 21882294
nsv515809 CNV Gain+Loss 19592680
nsv470250 CNV Gain 18288195
nsv6445 CNV Insertion 18451855

Variation tolerance for GRINA Gene

Residual Variation Intolerance Score: 48.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRINA Gene

HapMap Linkage Disequilibrium report
GRINA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRINA Gene

Disorders for GRINA Gene

Relevant External Links for GRINA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRINA
genes like me logo Genes that share disorders with GRINA: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRINA Gene

Publications for GRINA Gene

  1. Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. (PMID: 8406459) Collins C. … Hayden M.R. (Genomics 1993) 2 23 67
  2. Kinetic basis of partial agonism at NMDA receptors. (PMID: 19648915) Kussius C.L. … Popescu G.K. (Nat. Neurosci. 2009) 23 67
  3. Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function. (PMID: 18796005) Samson A.L. … Medcalf R.L. (J. Neurochem. 2008) 23 67
  4. Neurochemical organization of the macaque striate cortex: correlation of cytochrome oxidase with Na+K+ATPase, NADPH-diaphorase, nitric oxide synthase, and N-methyl-D-aspartate receptor subunit 1. (PMID: 9502244) Wong-Riley M. … Huang Z. (Neuroscience 1998) 23 67
  5. Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex. (PMID: 1719427) Kumar K.N. … Michaelis E.K. (Nature 1991) 2 67

Products for GRINA Gene

Sources for GRINA Gene

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