Aliases for GRIN3B Gene
External Ids for GRIN3B Gene
Previous GeneCards Identifiers for GRIN3B Gene
The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]
GeneCards Summary for GRIN3B Gene
GRIN3B (Glutamate Ionotropic Receptor NMDA Type Subunit 3B) is a Protein Coding gene. Diseases associated with GRIN3B include Lingual-Facial-Buccal Dyskinesia and Opioid Abuse. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Amyotrophic lateral sclerosis (ALS). GO annotations related to this gene include calcium channel activity and ionotropic glutamate receptor activity. An important paralog of this gene is GRIN3A.
UniProtKB/Swiss-Prot for GRIN3B Gene
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.