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GRIN3B Gene

protein-coding   GIFtS: 62
GCID: GC19P001000

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3B

  See GRIN3B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3B1 2     Glutamate [NMDA] Receptor Subunit 3B2
GluN3B2 3     Glutamate Receptor Ionotropic, NMDA 3B2
NMDAR3B2 3     NMDA Receptor Subunit 3B2
NR3B2 3     NMDA Type Glutamate Receptor Subunit NR3B2
N-Methyl-D-Aspartate Receptor Subtype 3B2 3     

External Ids:    HGNC: 167681   Entrez Gene: 1164442   Ensembl: ENSG000001160327   OMIM: 6066515   UniProtKB: O603913   

Export aliases for GRIN3B gene to outside databases

Previous GC identifers: GC19P001076 GC19M001069 GC19P000940 GC19P000947 GC19P000951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GRIN3B Gene:
GRIN3B (glutamate receptor, ionotropic, N-methyl-D-aspartate 3B) is a protein-coding gene. Diseases associated with GRIN3B include opioid abuse. GO annotations related to this gene include calcium channel activity and cation channel activity. An important paralog of this gene is GRIN2C.

UniProtKB/Swiss-Prot: NMD3B_HUMAN, O60391
Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low
calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine

summary for GRIN3B Gene:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.

Gene Wiki entry for GRIN3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIN3B gene promoter:
         Pax-5   NRSF form 1   COMP1   MyoD   XBP-1   AP-4   NRSF form 2   NF-E2 p45   NF-E2   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for GRIN3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIN3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

GRIN3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN3B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001000:  view genomic region     (about GC identifiers)

Start:
1,000,418 bp from pter      End:
1,009,731 bp from pter
Size:
9,314 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NMD3B_HUMAN, O60391 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, NMDA 3B precursor  
Size: 1043 amino acids; 112992 Da
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex
containing GRIN1 and GRIN2A (By similarity)
Sequence caution: Sequence=AAC12680.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5EAK7 Q7RTW9

Explore the universe of human proteins at neXtProt for GRIN3B: NX_O60391

Explore proteomics data for GRIN3B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn69, Asn344, Asn451, Asn465, Asn786
  • Modification sites at PhosphoSitePlus

  • See GRIN3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_619635.1  
    ENSEMBL proteins: 
     ENSP00000234389  

    GRIN3B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluN3B
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry O60391

    ProtoNet protein and cluster: O60391

    2 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature


    UniProtKB/Swiss-Prot: NMD3B_HUMAN, O60391
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily


    Find genes that share domains with GRIN3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMD3B_HUMAN, O60391
    Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low
    calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004972N-methyl-D-aspartate selective glutamate receptor activity IBA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005261cation channel activity ISS--
         
    Find genes that share ontologies with GRIN3B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GRIN3B:
     Decreased TP53 protein express 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grin3b):
     behavior/neurological  cellular  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with GRIN3B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GRIN3B: Grin3btm1Yaha Grin3b/Tmem259Grin3b/tm1Zhang

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIN3B
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    hsa-miR-3149 hsa-miR-548g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMD3B_HUMAN, O60391: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse,
    postsynaptic cell membrane (By similarity). Note=Requires the presence of GRIN1 to be targeted at the plasma
    membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0017146N-methyl-D-aspartate selective glutamate receptor complex NAS11735224
    GO:0030054cell junction IEA--
    GO:0030425dendrite IBA--
    GO:0043025neuronal cell body ISS11735224

    Find genes that share ontologies with GRIN3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIN3B About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    2Circadian entrainment
    Glutamatergic synapse0.39
    3Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    4RNA Polymerase I Promoter Opening
    Alcoholism0.34
    5Amyotrophic lateral sclerosis (ALS)
    Pathogenesis of ALS0.31


    Find genes that share SuperPaths with GRIN3B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIN3B
        Pathogenesis of ALS
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    Selected Kegg Pathways  (Kegg details for GRIN3B) (see all 6):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse
    Cocaine addiction
    Amphetamine addiction
    Nicotine addiction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GRIN3B
    Interactions:

        Search GeneGlobe Interaction Network for GRIN3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIN3B (O603913 ENSP000002343894) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    GRIN2AQ128793, ENSP000003325494I2D: score=1 STRING: ENSP00000332549
    CACNG2ENSP000003001054STRING: ENSP00000300105
    CACNG3ENSP000000052844STRING: ENSP00000005284
    CACNG4ENSP000002621384STRING: ENSP00000262138
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0007268synaptic transmission ----
    GO:0034220ion transmembrane transport IBA--
    GO:0035235ionotropic glutamate receptor signaling pathway ISS--
    GO:0035249synaptic transmission, glutamatergic IBA--

    Find genes that share ontologies with GRIN3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIN3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DL-AP5 Sodium saltSodium salt of DL-AP5 (Cat. No. 0105)[1303993-72-7]
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    QNZ 46NR2C/NR2D-selective NMDA receptor non-competitive antagonist[1237744-13-6]
    DL-AP5 Potent, selective NMDA antagonist [76326-31-3]

    3 HMDB Compounds for GRIN3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    MagnesiumMagnesium (see all 2)7439-95-4--

    5 DrugBank Compounds for GRIN3B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    OrphenadrineMephenamine (see all 7)83-98-7targetantagonist17139284 17016423 8788072
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423
    Tenocyclidine-- 21500-98-1targetantagonist2538766 17157509
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17502428
    Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7targetantagonist8968191

    1 Novoseek inferred chemical compound relationship for GRIN3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 64.1 10 20016182 (3), 11735224 (2), 15722182 (1), 11823786 (1) (see all 5)



    Find genes that share compounds with GRIN3B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRIN3B gene: 
    NM_138690.1  

    Unigene Cluster for GRIN3B:

    Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
    Hs.660378  [show with all ESTs]
    Unigene Representative Sequence: NM_138690
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234389(uc002lqo.1) ENST00000588335
    miRNA
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    Additional mRNA sequence: 

    AY507106.1 AY507107.1 

    1 DOTS entry:

    DT.80100861 

    16 AceView cDNA sequences:

    CB243197 AW407536 BK000070 BX422725 BM914493 CK429756 BM977634 AW401969 
    BQ709809 BE243713 BF847977 M62143 AA040686 BI050970 AA018099 AI082342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIN3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGTCGC
    GRIN3B Expression
    About this image


    GRIN3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
             Midbrain   
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
    GRIN3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIN3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660378
        Custom PCR Arrays for GRIN3B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRIN3B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grin3b1 , 5 glutamate receptor, ionotropic, NMDA3B1, 5 78.58(n)1
    80.02(a)1
      10 (39.72 cM)5
    1704831  NM_130455.21  NP_569722.11 
     799707155 
    chicken
    (Gallus gallus)
    Aves GRIN3B1 glutamate receptor, ionotropic, N-methyl-D-aspartate more 70.82(n)
    65.01(a)
      429171  XM_426726.4  XP_426726.4 
    lizard
    (Anolis carolinensis)
    Reptilia GRIN3B6
    glutamate receptor, ionotropic, N-methyl-D-asparta...
    67(a)
    1 ↔ 1
    AAWZ02037420(1270-12171)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grin3b1 glutamate receptor, ionotropic, N-methyl-D-aspartate more 58.84(n)
    61.06(a)
      100497172  XM_002937382.2  XP_002937428.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5713941 glutamate receptor ionotropic, NMDA 3A-like 62.3(n)
    64.46(a)
      571394  XM_694977.6  XP_700069.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ir8a6
    Ir25a6
    Ionotropic receptor 25a
    21(a)
    19(a)
    many ↔ many
    many ↔ many
    X(9126759-9130618)
    2L(4830846-4835300)
    worm
    (Caenorhabditis elegans)
    Secernentea glr-76
    glr-86
    Protein GLR-8 (glr-8) mRNA, complete cds
    21(a)
    20(a)
    many ↔ many
    many ↔ many
    X(2413909-2417892) WBGene00001618
    X(6506884-6509882) WBGene00001619


    ENSEMBL Gene Tree for GRIN3B (if available)
    TreeFam Gene Tree for GRIN3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIN3B gene
    GRIN2C2  GRIN12  GRIN3A2  GRIN2B2  GRIN2D2  GRIN2A2  
    1 SIMAP similar gene for GRIN3B using alignment to 3 protein entries:     NMD3B_HUMAN (see all proteins):
    GRIN3A

    Find genes that share paralogs with GRIN3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIN3B (see all 569)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347184771,2
    C,F--767699(+) CGGGTG/ATGGCC 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1407148431,2
    --767793(+) TGGCAC/TGCGTC 1 -- us2k10--------
    rs1851983401,2
    --767796(+) CACGCA/GTCACA 1 -- us2k10--------
    rs1180124961,2
    C,F--767816(+) GTCTGT/CTTTTA 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs31770321,2
    C,F--767829(+) AAAAGA/GGGATG 1 -- us2k11Minor allele frequency- G:0.07NA 120
    rs601031151,2
    C,F--767841(+) AAAGCC/TCCTCC 1 -- us2k12Minor allele frequency- T:0.13WA EA 238
    rs1905747931,2
    --767911(+) TGCTCA/GGCCCA 1 -- us2k10--------
    rs1436753161,2
    --767982(+) GGCCTC/TGCGGG 1 -- us2k10--------
    rs562200381,2
    C,F--768044(+) TGCCCG/AAGGGC 1 -- us2k13Minor allele frequency- A:0.05WA 122
    rs729716411,2
    C--768080(+) AAGGCA/GCTGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIN3B (1000418 - 1009731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIN3B (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910370CNV Loss21882294
    nsv470101CNV Loss18288195
    dgv3550n71CNV Loss21882294
    nsv910292CNV Loss21882294
    dgv3565n71CNV Loss21882294
    dgv3571n71CNV Loss21882294
    nsv910384CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3574n71CNV Loss21882294
    dgv3573n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIN3B
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIN3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606651    OMIM disorders: --

    1 disease for GRIN3B:    
    About MalaCards
    opioid abuse

    1 disease from the University of Copenhagen DISEASES database for GRIN3B:
    Opioid abuse

    Find genes that share disorders with GRIN3B           About GenesLikeMe

    Genetic Association Database (GAD): GRIN3B
    Human Genome Epidemiology (HuGE) Navigator: GRIN3B (3 documents)

    Export disorders for GRIN3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIN3B gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with GRIN3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. (PubMed id 11735224)1, 2, 9 Andersson O.... von Euler G. (Genomics 2001)
    2. Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus. (PubMed id 15722182)1, 2, 9 Bendel O.... von Euler G. (Neurosci. Lett. 2005)
    3. Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease. (PubMed id 20016182)1, 4, 9 Liu H.P....Tsai F.J. (Dement Geriatr Cogn Disord 2009)
    4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner. (PubMed id 11717388)1, 2 Nishi M.... Hayashi Y. (J. Neurosci. 2001)
    8. Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele. (PubMed id 17687115)1, 9 Niemann S....Hayashi Y. (Neurology 2008)
    9. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E I/4,and the risk of late-onset Alzheimer disease in African Americans. (PubMed id 23571587)1 Reitz C....Mayeux R. (JAMA 2013)
    10. Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport. (PubMed id 21948112)1 Mocchetti I....Avdoshina V. (Neurotox Res 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116444 HGNC: 16768 AceView: GRIN3B Ensembl:ENSG00000116032 euGenes: HUgn116444
    ECgene: GRIN3B Kegg: 116444 H-InvDB: GRIN3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRIN3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRIN3B gene:
    Search GeneIP for patents involving GRIN3B

    Licensable Technologies for GRIN3B gene:
     Tufts University:  Treatment of Obsessive-Compulsive Disorder and Compulsive Disorders (including Over-Eating, Alcoholism & Smoking)
    GeneCards and IP:
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