Aliases for GRIN3B Gene
External Ids for GRIN3B Gene
Previous GeneCards Identifiers for GRIN3B Gene
GeneCards Summary for GRIN3B Gene
GRIN3B (Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3B) is a Protein Coding gene. Diseases associated with GRIN3B include opioid abuse and hiv-1. Among its related pathways are Amphetamine addiction and RNA Polymerase I Promoter Opening. GO annotations related to this gene include calcium channel activity and cation channel activity. An important paralog of this gene is GRIN2A.
UniProtKB/Swiss-Prot for GRIN3B Gene
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.