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Aliases for GRIN3B Gene

Aliases for GRIN3B Gene

  • Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3B 2 3
  • N-Methyl-D-Aspartate Receptor Subtype 3B 3 4
  • NMDAR3B 3 4
  • GluN3B 3 4
  • NR3B 3 4
  • NMDA Type Glutamate Receptor Subunit NR3B 3
  • Glutamate Receptor Ionotropic, NMDA 3B 3
  • Glutamate [NMDA] Receptor Subunit 3B 3
  • NMDA Receptor Subunit 3B 3

External Ids for GRIN3B Gene

Previous GeneCards Identifiers for GRIN3B Gene

  • GC19P001076
  • GC19M001069
  • GC19P000940
  • GC19P000947
  • GC19P000951

Summaries for GRIN3B Gene

GeneCards Summary for GRIN3B Gene

GRIN3B (Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3B) is a Protein Coding gene. Diseases associated with GRIN3B include opioid abuse and hiv-1. Among its related pathways are Amphetamine addiction and RNA Polymerase I Promoter Opening. GO annotations related to this gene include calcium channel activity and cation channel activity. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot for GRIN3B Gene

  • NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine

Tocris Summary for GRIN3B Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Gene Wiki entry for GRIN3B Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN3B Gene

Genomics for GRIN3B Gene

Regulatory Elements for GRIN3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRIN3B Gene

Start:
1,000,419 bp from pter
End:
1,009,732 bp from pter
Size:
9,314 bases
Orientation:
Plus strand

Genomic View for GRIN3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIN3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN3B Gene

Proteins for GRIN3B Gene

  • Protein details for GRIN3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60391-NMD3B_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, NMDA 3B
    Protein Accession:
    O60391
    Secondary Accessions:
    • Q5EAK7
    • Q7RTW9

    Protein attributes for GRIN3B Gene

    Size:
    1043 amino acids
    Molecular mass:
    112992 Da
    Quaternary structure:
    • Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).
    SequenceCaution:
    • Sequence=AAC12680.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GRIN3B Gene

Proteomics data for GRIN3B Gene at MOPED

Post-translational modifications for GRIN3B Gene

  • Glycosylation at Asn69, Asn344, Asn451, Asn465, and Asn786
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIN3B Gene

Domains for GRIN3B Gene

Gene Families for GRIN3B Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for GRIN3B Gene

Graphical View of Domain Structure for InterPro Entry

O60391

UniProtKB/Swiss-Prot:

NMD3B_HUMAN :
  • O60391
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.
genes like me logo Genes that share domains with GRIN3B: view

Function for GRIN3B Gene

Molecular function for GRIN3B Gene

UniProtKB/Swiss-Prot Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine

Gene Ontology (GO) - Molecular Function for GRIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity IBA --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005261 cation channel activity ISS --
GO:0005262 contributes_to calcium channel activity ISS 11735224
genes like me logo Genes that share ontologies with GRIN3B: view
genes like me logo Genes that share phenotypes with GRIN3B: view

Animal Models for GRIN3B Gene

MGI Knock Outs for GRIN3B:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIN3B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRIN3B Gene

Localization for GRIN3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN3B Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIN3B Gene COMPARTMENTS Subcellular localization image for GRIN3B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex NAS 11735224
GO:0030054 cell junction IEA --
GO:0030425 dendrite IBA --
GO:0043025 neuronal cell body ISS 11735224
genes like me logo Genes that share ontologies with GRIN3B: view

Pathways for GRIN3B Gene

genes like me logo Genes that share pathways with GRIN3B: view

Gene Ontology (GO) - Biological Process for GRIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IBA --
GO:0035235 ionotropic glutamate receptor signaling pathway ISS --
GO:0035249 synaptic transmission, glutamatergic IBA --
GO:0051205 protein insertion into membrane ISS 11735224
GO:0051924 regulation of calcium ion transport ISS 11735224
genes like me logo Genes that share ontologies with GRIN3B: view

Compounds for GRIN3B Gene

(5) Tocris Compounds for GRIN3B Gene

Compound Action Cas Number
(+)-MK 801 maleate Non-competitive NMDA antagonist; acts at ion channel site [77086-22-7]
D-AP5 Potent, selective NMDA antagonist; more active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
DL-AP5 Potent, selective NMDA antagonist [76326-31-3]
DL-AP5 Sodium salt Sodium salt of DL-AP5 (Cat. No. 0105) [1303993-72-7]
Ro 25-6981 maleate Subtype-selective NR2B antagonist [1312991-76-6]

(3) HMDB Compounds for GRIN3B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
56-86-0
Magnesium
  • Magnesium
7439-95-4

(5) Drugbank Compounds for GRIN3B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glycine
  • 2-Aminoacetic acid
56-40-6 target
Halothane
  • 2-Bromo-2-Chloro-1,1,1-Trifluoroethane
151-67-7 target antagonist
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Orphenadrine
  • Mephenamine
83-98-7 target antagonist
Tenocyclidine
21500-98-1 target antagonist

(1) Novoseek inferred chemical compound relationships for GRIN3B Gene

Compound -log(P) Hits PubMed IDs
nmda 64.1 8
genes like me logo Genes that share compounds with GRIN3B: view

Transcripts for GRIN3B Gene

mRNA/cDNA for GRIN3B Gene

(16) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIN3B Gene

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIN3B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GRIN3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN3B Gene

No ASD Table

Relevant External Links for GRIN3B Gene

GeneLoc Exon Structure for
GRIN3B
ECgene alternative splicing isoforms for
GRIN3B

Expression for GRIN3B Gene

mRNA expression in normal human tissues for GRIN3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIN3B Gene

This gene is overexpressed in Fallopian Tube (5.3) and Cervix - Endocervix (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIN3B Gene

SOURCE GeneReport for Unigene cluster for GRIN3B Gene Hs.660378

genes like me logo Genes that share expressions with GRIN3B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRIN3B Gene

Orthologs for GRIN3B Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIN3B 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIN3B 35
  • 80.03 (n)
  • 77.46 (a)
GRIN3B 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIN3B 35
  • 83.81 (n)
  • 82.53 (a)
mouse
(Mus musculus)
Mammalia Grin3b 35
  • 78.58 (n)
  • 80.02 (a)
Grin3b 16
Grin3b 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIN3B 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIN3B 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grin3b 35
  • 78.83 (n)
  • 80.46 (a)
chicken
(Gallus gallus)
Aves GRIN3B 35
  • 70.82 (n)
  • 65.01 (a)
GRIN3B 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIN3B 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grin3b 35
  • 58.84 (n)
  • 61.06 (a)
zebrafish
(Danio rerio)
Actinopterygii grin3b 36
  • 48 (a)
OneToMany
GRIN3B (2 of 2) 36
  • 52 (a)
OneToMany
LOC571394 35
  • 62.3 (n)
  • 64.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ir25a 36
  • 19 (a)
ManyToMany
Ir8a 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-7 36
  • 21 (a)
ManyToMany
glr-8 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for GRIN3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIN3B Gene

ENSEMBL:
Gene Tree for GRIN3B (if available)
TreeFam:
Gene Tree for GRIN3B (if available)

Paralogs for GRIN3B Gene

Paralogs for GRIN3B Gene

Selected SIMAP similar genes for GRIN3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRIN3B: view

Variants for GRIN3B Gene

Sequence variations from dbSNP and Humsavar for GRIN3B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs739881 -- 1,006,459(-) aaaaa(A/T)aaTAA intron-variant
rs739882 -- 1,006,573(-) tccca(C/G)cactg intron-variant
rs739883 -- 1,006,769(-) CAGTC(A/G)GCTCA intron-variant
rs2240154 - 1,003,173(+) GGAGA(C/T)GCTGC reference, missense
rs2240155 -- 1,003,809(+) Aggcc(A/G)gacgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIN3B Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3513n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv3564n71 CNV Loss 21882294
dgv3565n71 CNV Loss 21882294
dgv3566n71 CNV Loss 21882294
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
nsv910361 CNV Gain+Loss 21882294
dgv3567n71 CNV Loss 21882294
dgv3568n71 CNV Loss 21882294
dgv3569n71 CNV Loss 21882294
nsv910370 CNV Loss 21882294
dgv3570n71 CNV Loss 21882294
dgv3571n71 CNV Loss 21882294
dgv3572n71 CNV Loss 21882294
nsv910376 CNV Loss 21882294
dgv3573n71 CNV Loss 21882294
nsv910383 CNV Gain 21882294
nsv910384 CNV Loss 21882294
dgv3574n71 CNV Loss 21882294
dgv3575n71 CNV Loss 21882294

Relevant External Links for GRIN3B Gene

HapMap Linkage Disequilibrium report
GRIN3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN3B Gene

Disorders for GRIN3B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for GRIN3B Gene including...

Search for GRIN3B Gene in MalaCards »

(1) University of Copenhagen DISEASES for GRIN3B Gene

Relevant External Links for GRIN3B

Genetic Association Database (GAD)
GRIN3B
Human Genome Epidemiology (HuGE) Navigator
GRIN3B
genes like me logo Genes that share disorders with GRIN3B: view

No data available for UniProtKB/Swiss-Prot for GRIN3B Gene

Publications for GRIN3B Gene

  1. Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease. (PMID: 20016182) Liu H.P. … Tsai F.J. (Dement Geriatr Cogn Disord 2009) 3 23 48
  2. Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. (PMID: 11735224) Andersson O. … von Euler G. (Genomics 2001) 3 4 23
  3. Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus. (PMID: 15722182) Bendel O. … von Euler G. (Neurosci. Lett. 2005) 3 4 23
  4. Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner. (PMID: 11717388) Nishi M. … Hayashi Y. (J. Neurosci. 2001) 3 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4

Products for GRIN3B Gene

Sources for GRIN3B Gene

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