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Aliases for GRIN3A Gene

Aliases for GRIN3A Gene

  • Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A 2 3
  • NR3A 3 4 6
  • N-Methyl-D-Aspartate Receptor Subtype 3A 3 4
  • NMDAR-L 3 4
  • NMDAR3A 3 4
  • GluN3A 3 4
  • Glutamate Receptor Ionotropic, NMDA 3A 3
  • Glutamate [NMDA] Receptor Subunit 3A 3
  • KIAA1973 4

External Ids for GRIN3A Gene

Previous GeneCards Identifiers for GRIN3A Gene

  • GC09M095131
  • GC09M096075
  • GC09M097789
  • GC09M099711
  • GC09M101411
  • GC09M103371
  • GC09M104331
  • GC09M073932

Summaries for GRIN3A Gene

Entrez Gene Summary for GRIN3A Gene

  • This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIN3A Gene

GRIN3A (Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A) is a Protein Coding gene. Among its related pathways are Amphetamine addiction and RNA Polymerase I Promoter Opening. GO annotations related to this gene include identical protein binding and extracellular-glutamate-gated ion channel activity. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot for GRIN3A Gene

  • NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).

Tocris Summary for GRIN3A Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Gene Wiki entry for GRIN3A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN3A Gene

Genomics for GRIN3A Gene

Regulatory Elements for GRIN3A Gene

Genomic Location for GRIN3A Gene

Start:
101,569,352 bp from pter
End:
101,738,580 bp from pter
Size:
169,229 bases
Orientation:
Minus strand

Genomic View for GRIN3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIN3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN3A Gene

Proteins for GRIN3A Gene

  • Protein details for GRIN3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCU5-NMD3A_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, NMDA 3A
    Protein Accession:
    Q8TCU5
    Secondary Accessions:
    • B3DLF9
    • Q5VTR3
    • Q8TF29
    • Q8WXI6

    Protein attributes for GRIN3A Gene

    Size:
    1115 amino acids
    Molecular mass:
    125465 Da
    Quaternary structure:
    • Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).
    SequenceCaution:
    • Sequence=BAB85559.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GRIN3A Gene

Proteomics data for GRIN3A Gene at MOPED

Post-translational modifications for GRIN3A Gene

  • N-glycosylated.
  • Glycosylation at Asn145, Asn264, Asn275, Asn285, Asn296, Asn426, Asn439, Asn549, Asn565, and Asn886
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIN3A Gene

Domains for GRIN3A Gene

Gene Families for GRIN3A Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for GRIN3A Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCU5

UniProtKB/Swiss-Prot:

NMD3A_HUMAN :
  • Q8TCU5
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily.
genes like me logo Genes that share domains with GRIN3A: view

Function for GRIN3A Gene

Molecular function for GRIN3A Gene

UniProtKB/Swiss-Prot Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).

Gene Ontology (GO) - Molecular Function for GRIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004972 contributes_to N-methyl-D-aspartate selective glutamate receptor activity ISS --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding IPI 17658481
genes like me logo Genes that share ontologies with GRIN3A: view
genes like me logo Genes that share phenotypes with GRIN3A: view

Animal Models for GRIN3A Gene

MGI Knock Outs for GRIN3A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRIN3A Gene

Localization for GRIN3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN3A Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIN3A Gene COMPARTMENTS Subcellular localization image for GRIN3A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IDA 17997397
GO:0016021 integral component of membrane NAS 11880201
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex IDA 17997397
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIN3A: view

Pathways for GRIN3A Gene

genes like me logo Genes that share pathways with GRIN3A: view

Gene Ontology (GO) - Biological Process for GRIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport ISS --
GO:0016358 dendrite development IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0035235 ionotropic glutamate receptor signaling pathway IBA --
GO:0035249 synaptic transmission, glutamatergic IBA --
genes like me logo Genes that share ontologies with GRIN3A: view

Compounds for GRIN3A Gene

(5) Tocris Compounds for GRIN3A Gene

Compound Action Cas Number
(+)-MK 801 maleate Non-competitive NMDA antagonist; acts at ion channel site [77086-22-7]
D-AP5 Potent, selective NMDA antagonist; more active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
DL-AP5 Potent, selective NMDA antagonist [76326-31-3]
DL-AP5 Sodium salt Sodium salt of DL-AP5 (Cat. No. 0105) [1303993-72-7]
Ro 25-6981 maleate Subtype-selective NR2B antagonist [1312991-76-6]

(4) HMDB Compounds for GRIN3A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Dextromethorphan
  • Bayer Select Flu Relief
6700-34-1
Ethanol
  • 1-Hydroxyethane
64-17-5
Magnesium
  • Magnesium
7439-95-4

(18) Drugbank Compounds for GRIN3A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acamprosate
  • 3-(Acetylamino)propanesulphonic acid
77337-76-9 target antagonist
Amantadine
  • 1-aminoadamantane
768-94-5 target antagonist
Chloroprocaine
  • Chloroprocain
133-16-4 target antagonist
Dextromethorphan
  • D-Methorphan
125-71-3 target antagonist
Ethanol
  • Absolute Alcohol
64-17-5 target antagonist

(3) Novoseek inferred chemical compound relationships for GRIN3A Gene

Compound -log(P) Hits PubMed IDs
nmda 73.2 18
glutamate 42.4 3
calcium 0 1
genes like me logo Genes that share compounds with GRIN3A: view

Transcripts for GRIN3A Gene

mRNA/cDNA for GRIN3A Gene

Unigene Clusters for GRIN3A Gene

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN3A Gene

No ASD Table

Relevant External Links for GRIN3A Gene

GeneLoc Exon Structure for
GRIN3A
ECgene alternative splicing isoforms for
GRIN3A

Expression for GRIN3A Gene

mRNA expression in normal human tissues for GRIN3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIN3A Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (8.5), Brain - Hypothalamus (5.3), Brain - Frontal Cortex (BA9) (5.2), and Brain - Cortex (4.7).

SOURCE GeneReport for Unigene cluster for GRIN3A Gene Hs.654783

genes like me logo Genes that share expressions with GRIN3A: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for GRIN3A Gene

Orthologs for GRIN3A Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIN3A 35
  • 98.98 (n)
  • 99.1 (a)
GRIN3A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIN3A 35
  • 92.1 (n)
  • 93.72 (a)
GRIN3A 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIN3A 35
  • 92.94 (n)
  • 94.98 (a)
GRIN3A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grin3a 35
  • 89.21 (n)
  • 93.36 (a)
Grin3a 16
Grin3a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIN3A 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIN3A 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grin3a 35
  • 88.76 (n)
  • 92.65 (a)
chicken
(Gallus gallus)
Aves GRIN3A 35
  • 77.21 (n)
  • 83.35 (a)
GRIN3A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIN3A 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grin3a 35
  • 70.72 (n)
  • 78.2 (a)
zebrafish
(Danio rerio)
Actinopterygii GRIN3A 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nmdar2 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nmr-2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for GRIN3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIN3A Gene

ENSEMBL:
Gene Tree for GRIN3A (if available)
TreeFam:
Gene Tree for GRIN3A (if available)

Paralogs for GRIN3A Gene

Paralogs for GRIN3A Gene

Selected SIMAP similar genes for GRIN3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIN3A: view

Variants for GRIN3A Gene

Sequence variations from dbSNP and Humsavar for GRIN3A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs724556 -- 101,662,786(+) ATGTG(G/T)TGGTA intron-variant
rs729688 -- 101,610,184(+) AAAAG(A/C)CACGC intron-variant
rs766551 -- 101,665,774(+) GAAAA(A/G)TGAAA intron-variant
rs942139 -- 101,573,738(-) AATGA(C/T)ACCCA intron-variant
rs942141 -- 101,609,454(-) TCTTA(A/C)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIN3A Gene

Variant ID Type Subtype PubMed ID
nsv893627 CNV Loss 21882294
nsv831672 CNV Gain 17160897
nsv527229 CNV Loss 19592680
nsv6642 CNV Loss 18451855
nsv415939 CNV Loss 16902084
esv1003325 CNV Deletion 20482838
esv2606620 CNV Deletion 19546169
nsv512111 CNV Loss 21212237
esv1995711 CNV Deletion 18987734
esv2738843 CNV Deletion 23290073
esv3164 CNV Deletion 18987735
dgv266n6 CNV Loss 16902084
esv5546 CNV Loss 19470904
esv991727 CNV Deletion 20482838
esv1035979 CNV Deletion 17803354
esv2671974 CNV Deletion 23128226
esv26854 CNV Loss 19812545

Relevant External Links for GRIN3A Gene

HapMap Linkage Disequilibrium report
GRIN3A
Human Gene Mutation Database (HGMD)
GRIN3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN3A Gene

Disorders for GRIN3A Gene

Relevant External Links for GRIN3A

Genetic Association Database (GAD)
GRIN3A
Human Genome Epidemiology (HuGE) Navigator
GRIN3A
genes like me logo Genes that share disorders with GRIN3A: view

No data available for UniProtKB/Swiss-Prot for GRIN3A Gene

Publications for GRIN3A Gene

  1. Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease. (PMID: 20016182) Liu H.P. … Tsai F.J. (Dement Geriatr Cogn Disord 2009) 3 23 48
  2. Cloning and expression of the human NMDA receptor subunit NR3A. (PMID: 11880201) Eriksson M. … Sundstroem E. (Neurosci. Lett. 2002) 3 4 23
  3. Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans. (PMID: 17214563) Gallinat J. … Winterer G. (J Cogn Neurosci 2007) 3 23 48
  4. Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. (PMID: 11735224) Andersson O. … von Euler G. (Genomics 2001) 3 4 23
  5. Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene (GRIN3A) reveals no association with schizophrenia. (PMID: 19665356) Shen Y.C. … Chen C.H. (Schizophr. Res. 2009) 3 23 48

Products for GRIN3A Gene

Sources for GRIN3A Gene

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