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GRIN3A Gene

protein-coding   GIFtS: 61
GCID: GC09M104331

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A1 2     N-Methyl-D-Aspartate Receptor Subtype 3A2 3
NR3A2 3 5     Glutamate [NMDA] Receptor Subunit 3A2
GluN3A2 3     Glutamate Receptor Ionotropic, NMDA 3A2
NMDAR-L2 3     KIAA19733
NMDAR3A2 3     

External Ids:    HGNC: 167671   Entrez Gene: 1164432   Ensembl: ENSG000001987857   OMIM: 6066505   UniProtKB: Q8TCU53   

Export aliases for GRIN3A gene to outside databases

Previous GC identifers: GC09M095131 GC09M096075 GC09M097789 GC09M099711 GC09M101411 GC09M103371 GC09M073932


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIN3A Gene:
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of
glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous
system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout
mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by
modulating NMDA receptor activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIN3A Gene:
GRIN3A (glutamate receptor, ionotropic, N-methyl-D-aspartate 3A) is a protein-coding gene. Diseases associated with GRIN3A include paine syndrome, and nicotine addiction. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and identical protein binding. An important paralog of this gene is GRIN2C.

UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5
Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low
calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in
the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)

summary for GRIN3A Gene:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.

Gene Wiki entry for GRIN3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIN3A gene promoter:
         E2F-4   E2F-3a   E2F-5   NRSF form 1   E2F-2   NRSF form 2   CBF-B   E2F   E2F-1   CBF-A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIN3A promoter sequence
   Search Chromatin IP Primers for GRIN3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIN3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q31.1

GRIN3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN3A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M104331:  view genomic region     (about GC identifiers)

Start:
104,331,634 bp from pter      End:
104,500,862 bp from pter
Size:
169,229 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, NMDA 3A precursor  
Size: 1115 amino acids; 125465 Da
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with
GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when
NMDARs are stimulated by NMDA (By similarity)
Developmental stage: Expressed in fetal brain
Sequence caution: Sequence=BAB85559.1; Type=Erroneous initiation;
Secondary accessions: B3DLF9 Q5VTR3 Q8TF29 Q8WXI6

Explore the universe of human proteins at neXtProt for GRIN3A: NX_Q8TCU5

Explore proteomics data for GRIN3A at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn145, Asn264, Asn275, Asn285, Asn296, Asn426, Asn439, Asn549, Asn565, Asn886
  • Modification sites at PhosphoSitePlus

  • See GRIN3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_597702.2  
    ENSEMBL proteins: 
     ENSP00000355155  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluN3A
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8TCU5

    ProtoNet protein and cluster: Q8TCU5

    2 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature


    UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily


    GRIN3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMD3A_HUMAN, Q8TCU5
    Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low
    calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in
    the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004972contributes to N-methyl-D-aspartate selective glutamate receptor activity ISS--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005262calcium channel activity IEA--
         
    GRIN3A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grin3a):
     behavior/neurological  nervous system  normal  vision/eye 

    GRIN3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRIN3A: Grin3atm1Nnk Grin3atm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIN3A
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    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-376b hsa-miR-300 hsa-miR-200a hsa-miR-3148 hsa-miR-2113 hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIN3A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMD3A_HUMAN, Q8TCU5: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse,
    postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
    density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the
    presence of GRIN1 to be targeted at the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane IDA17997397
    GO:0016021integral component of membrane NAS11880201
    GO:0017146N-methyl-D-aspartate selective glutamate receptor complex IDA17997397
    GO:0030054cell junction IEA--

    GRIN3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIN3A About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    2Circadian entrainment
    Glutamatergic synapse0.39
    3Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    4RNA Polymerase I Promoter Opening
    Alcoholism0.34
    5Amyotrophic lateral sclerosis (ALS)
    Pathogenesis of ALS0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIN3A
        Pathogenesis of ALS
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    Selected Kegg Pathways  (Kegg details for GRIN3A) (see all 6):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse
    Cocaine addiction
    Amphetamine addiction
    Nicotine addiction


    GRIN3A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for GRIN3A
    Interactions:

        GeneGlobe Interaction Network for GRIN3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIN3A (Q8TCU53 ENSP000003551554) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    GRIN2AQ128793, ENSP000003325494I2D: score=1 STRING: ENSP00000332549
    DYNLL1P631673I2D: score=2 
    CEBPAP497153I2D: score=1 
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006816calcium ion transport ISS--
    GO:0016358dendrite development IEA--
    GO:0034220ion transmembrane transport IBA--
    GO:0035235ionotropic glutamate receptor signaling pathway IBA--

    GRIN3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIN3A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DL-AP5 Sodium saltSodium salt of DL-AP5 (Cat. No. 0105)[1303993-72-7]
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    QNZ 46NR2C/NR2D-selective NMDA receptor non-competitive antagonist[1237744-13-6]
    DL-AP5 Potent, selective NMDA antagonist [76326-31-3]

    4 HMDB Compounds for GRIN3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DextromethorphanBayer Select Flu Relief (see all 58)6700-34-1--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected DrugBank Compounds for GRIN3A (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EthanolAbsolute Alcohol (see all 34)64-17-5targetantagonist21163614 17139284 21204417 17016423 21289476 21204407
    DextromethorphanD-Methorphan (see all 20)125-71-3targetantagonist10064839 17139284 2897648 17016423 18812887
    MemantineMemantina [INN-Spanish] (see all 5)19982-08-2targetantagonist16377242 11823786 14530799 16719808 17502428
    EthopropazineAethopropropazin (see all 25)1094-08-2targetantagonist2849655 17139284 17016423 12681372
    Ketamine(-)-Ketamine (see all 7)6740-88-1targetantagonist2858237 14740534 18175098 17502428
    Procaine-- 59-46-1targetantagonist16299047 17139284 17016423 11812692
    Methadone(+/-)-Methadone (see all 8)76-99-3targetantagonist17139284 17016423 19717013
    OrphenadrineMephenamine (see all 7)83-98-7targetantagonist17139284 17016423 8788072
    Amantadine1-aminoadamantane (see all 9)768-94-5targetantagonist15800186 10443547
    ChloroprocaineChloroprocain (see all 3)133-16-4targetantagonist17139284 17016423

    3 Novoseek inferred chemical compound relationships for GRIN3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 73.2 20 20016182 (2), 10366738 (2), 17617428 (2), 7472413 (2) (see all 13)
    glutamate 42.4 3 19665356 (1), 11823786 (1), 17214563 (1)
    calcium 0 1 18296432 (1)



    GRIN3A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRIN3A gene: 
    NM_133445.2  

    Unigene Cluster for GRIN3A:

    Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
    Hs.654783  [show with all ESTs]
    Unigene Representative Sequence: BC167432
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361820(uc004bbo.2 uc004bbp.2 uc004bbq.1) ENST00000479772

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    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-376b hsa-miR-300 hsa-miR-200a hsa-miR-3148 hsa-miR-2113 hsa-miR-3688-3p
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      QuantiFast Probe-based Assays in human, mouse, rat GRIN3A

    Additional mRNA sequence: 

    AB075853.1 AF416558.1 AJ416950.2 AK125562.1 AK127342.1 AL137422.1 AL359651.1 BC029757.1 
    BC132866.1 BC132868.1 BC167432.1 

    5 DOTS entries:

    DT.303624  DT.101980616  DT.91659709  DT.101958359  DT.75138664 

    20 AceView cDNA sequences:

    NM_133445 BX282046 AB075853 AL137422 Z40440 BC029757 BF791640 Z44549 
    AL359651 F05465 BX643290 AJ416950 AK127342 BF969398 AW166288 AF416558 
    BQ930853 R61128 AI613310 AW956215 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIN3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGATTAG
    GRIN3A Expression
    About this image


    GRIN3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             Oligodendrocyte progenitor cells
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Bone (Muscoskeletal System)
             Autopod Long Bone
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
    GRIN3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIN3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654783
        Custom PCR Arrays for GRIN3A
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for GRIN3A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grin3a1 , 5 glutamate receptor ionotropic, NMDA3A1, 5 89.21(n)1
    93.36(a)1
      4 (26.72 cM)5
    2424431  NM_001033351.21  NP_001028523.11 
     496616115 
    chicken
    (Gallus gallus)
    Aves GRIN3A1 glutamate receptor, ionotropic, N-methyl-D-aspartate more 77.21(n)
    83.35(a)
      769001  XM_001232181.3  XP_001232182.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIN3A6
    glutamate receptor, ionotropic, N-methyl-D-asparta...
    79(a)
    1 ↔ 1
    2(64717580-64924025)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grin3a1 glutamate receptor, ionotropic, N-methyl-D-aspartate more 70.72(n)
    78.2(a)
      100486849  XM_002938539.2  XP_002938585.2 
    zebrafish
    (Danio rerio)
    Actinopterygii GRIN3A6
    glutamate receptor, ionotropic, N-methyl-D-asparta...
    62(a)
    1 ↔ 1
    10(4511584-4547733) ENSDARG00000075802
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmdar26
    NMDA receptor 2
    21(a)
    1 → many
    X(1380259-1401842)
    worm
    (Caenorhabditis elegans)
    Secernentea nmr-26
    Protein NMR-2, isoform a
    23(a)
    1 → many
    V(15005938-15011660) WBGene00003775


    ENSEMBL Gene Tree for GRIN3A (if available)
    TreeFam Gene Tree for GRIN3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIN3A gene
    GRIN2C2  GRIN12  GRIN2B2  GRIN2D2  GRIN2A2  GRIN3B2  
    2 SIMAP similar genes for GRIN3A using alignment to 2 protein entries:     NMD3A_HUMAN (see all proteins):
    GRIN3B    GRIK3

    GRIN3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIN3A (see all 3413)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119202921,2
    C,F--104331142(+) TCGGGC/TGGGAG 1 -- ds50014Minor allele frequency- T:0.50WA NA CSA 8
    rs1847413341,2
    C--104331227(+) CCTGGC/TGACAG 1 -- ds50010--------
    rs3694100801,2
    C--104331268(+) AAAAA-/GAAAAA 1 -- ds50010--------
    rs1401502441,2
    --104331310(+) TTCACA/TATTGT 1 -- ds50010--------
    rs1128143011,2
    C,F--104331517(+) CTTTGG/AACTAT 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1913720941,2
    --104331555(+) ATTAAC/TGGGTC 1 -- ds50010--------
    rs1844019051,2
    --104331676(+) AAACTA/GAAGAT 1 -- ut310--------
    rs1897494121,2
    --104331720(+) TGGTTA/GTACAA 1 -- ut310--------
    rs1503276311,2
    C--104331736(+) GTGGCA/TGGAGC 1 -- ut310--------
    rs1380189421,2
    --104331801(+) CGGAGC/TGATTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GRIN3A (104331634 - 104500862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIN3A (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1035979CNV Deletion17803354
    esv2738843CNV Deletion23290073
    esv1995711CNV Deletion18987734
    esv2606620CNV Deletion19546169
    esv1003325CNV Deletion20482838
    esv3164CNV Deletion18987735
    esv991727CNV Deletion20482838
    esv2671974CNV Deletion23128226
    nsv6642CNV Loss18451855
    nsv415939CNV Loss16902084

    Human Gene Mutation Database (HGMD): GRIN3A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIN3A
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIN3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606650    OMIM disorders: --

    17 diseases for GRIN3A:    
    About MalaCards
    paine syndrome    nicotine addiction    nicotine dependence    bipolar disorder
    esophageal squamous cell carcinoma    hiv-1    osteosarcoma    esophagitis
    squamous cell carcinoma    neuroblastoma    schizophrenia    neuronitis
    cerebritis    alzheimer's disease    obesity    prostatitis
    prostate cancer


    GRIN3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): GRIN3A
    Human Genome Epidemiology (HuGE) Navigator: GRIN3A (13 documents)

    Export disorders for GRIN3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIN3A gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with GRIN3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene (GRIN3A) reveals no association with schizophrenia. (PubMed id 19665356)1, 4, 9 Shen Y.C....Chen C.H. (Schizophr. Res. 2009)
    2. Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans. (PubMed id 17214563)1, 4, 9 Gallinat J....Winterer G. (J Cogn Neurosci 2007)
    3. Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease. (PubMed id 20016182)1, 4, 9 Liu H.P....Tsai F.J. (Dement Geriatr Cogn Disord 2009)
    4. Cloning and expression of the human NMDA receptor subunit NR3A. (PubMed id 11880201)1, 2, 9 Eriksson M.... Sundstroem E. (Neurosci. Lett. 2002)
    5. Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. (PubMed id 11735224)1, 2, 9 Andersson O.... von Euler G. (Genomics 2001)
    6. Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers. (PubMed id 20084518)1, 4 Ma J.Z....Li M.D. (Hum. Genet. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116443 HGNC: 16767 AceView: GRIN3A Ensembl:ENSG00000198785 euGenes: HUgn116443
    ECgene: GRIN3A Kegg: 116443 H-InvDB: GRIN3A

    (According to HUGE)
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    HUGE: KIAA1973

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for GRIN3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRIN3A gene:
    Search GeneIP for patents involving GRIN3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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