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Set Analyses:

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GRIN3A Gene

protein-coding GIFtS: 61
GCID: GC09M104331

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A¹ ²		N-Methyl-D-Aspartate Receptor Subtype 3A² ³
NR3A² ³ ⁵		Glutamate [NMDA] Receptor Subunit 3A²
GluN3A² ³		Glutamate Receptor Ionotropic, NMDA 3A²
NMDAR-L² ³		KIAA1973³
NMDAR3A² ³

External Ids:	HGNC: 16767¹	Entrez Gene: 116443²	Ensembl: ENSG00000198785⁷	OMIM: 606650⁵	UniProtKB: Q8TCU5³

Export aliases for GRIN3A gene to outside databases

Previous GC identifers: GC09M095131 GC09M096075 GC09M097789 GC09M099711 GC09M101411 GC09M103371 GC09M073932

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIN3A Gene:

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of

glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous

system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout

mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by

modulating NMDA receptor activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIN3A Gene:

GRIN3A (glutamate receptor, ionotropic, N-methyl-D-aspartate 3A) is a protein-coding gene. Diseases associated with GRIN3A include paine syndrome, and nicotine addiction. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and identical protein binding. An important paralog of this gene is GRIN2C.

UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5

Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low

calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in

the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)

summary for GRIN3A Gene:

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and

AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)

subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane

potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA

receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the

postsynaptic region where it activates several signaling cascades, including pathways leading to the

induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in

excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions

including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and

neuropathic pain syndromes.

Gene Wiki entry for GRIN3A Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000009.12 NC_018920.2 NT_008470.20

Regulatory elements:

Regulatory transcription factor binding sites in the GRIN3A gene promoter:
E2F-4 E2F-3a E2F-5 NRSF form 1 E2F-2 NRSF form 2 CBF-B E2F E2F-1 CBF-A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: GRIN3A promoter sequence

Search Chromatin IP Primers for GRIN3A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIN3A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q31.1

GRIN3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN3A gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M104331: view genomic region (about GC identifiers)

Start:	104,331,634 bp from pter	End:	104,500,862 bp from pter
Size:	169,229 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5 (See protein sequence)

Recommended Name: Glutamate receptor ionotropic, NMDA 3A precursor

Size: 1115 amino acids; 125465 Da

Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)

and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with

GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when

NMDARs are stimulated by NMDA (By similarity)

Developmental stage: Expressed in fetal brain

Sequence caution: Sequence=BAB85559.1; Type=Erroneous initiation;

Secondary accessions: B3DLF9 Q5VTR3 Q8TF29 Q8WXI6

Explore the universe of human proteins at neXtProt for GRIN3A: NX_Q8TCU5

Explore proteomics data for GRIN3A at MOPED

Post-translational modifications:

N-glycosylated (By similarity)¹

Glycosylation² at Asn145, Asn264, Asn275, Asn285, Asn296, Asn426, Asn439, Asn549, Asn565, Asn886

Modification sites at PhosphoSitePlus

See GRIN3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_597702.2

ENSEMBL proteins:

ENSP00000355155

GRIN3A Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic

GR: Glutamate receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: GluN3A

Ionotropic glutamate receptors

5 InterPro protein domains:

IPR028082 Peripla_BP_I

IPR019594 Glu_rcpt_Glu/Gly-bd

IPR001638 SBP_bac_3

IPR001320 Iontro_glu_rcpt

IPR001508 NMDA_rcpt

Graphical View of Domain Structure for InterPro Entry Q8TCU5

ProtoNet protein and cluster: Q8TCU5

2 Blocks protein domains:

IPB001320 Ionotropic glutamate receptor

IPB001508 NMDA receptor signature

UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily

GRIN3A for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NMD3A_HUMAN, Q8TCU5

Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low

calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in

the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)

Gene Ontology (GO): Selected molecular function terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004970	ionotropic glutamate receptor activity	--	--
GO:0004972	contributes to N-methyl-D-aspartate selective glutamate receptor activity	ISS	--
GO:0005215	transporter activity	--	--
GO:0005234	extracellular-glutamate-gated ion channel activity	IBA	--
GO:0005262	calcium channel activity	IEA	--

GRIN3A for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Grin3a):

behavior/neurological

nervous system

normal

vision/eye

GRIN3A for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for GRIN3A: Grin3a^tm1Nnk Grin3a^tm1Lex

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIN3A

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIN3A

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genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIN3A

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		SwitchGear 3'UTR luciferase reporter plasmid: GRIN3A 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN3A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NMD3A_HUMAN, Q8TCU5: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse,

postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic

density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the

presence of GRIN1 to be targeted at the plasma membrane (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
cytoskeleton	2
endoplasmic reticulum	1
nucleus	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0014069	postsynaptic density	IEA	--
GO:0016020	membrane	IDA	17997397
GO:0016021	integral component of membrane	NAS	11880201
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	IDA	17997397
GO:0030054	cell junction	IEA	--

GRIN3A for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for GRIN3A About (see all 8)

See pathways by source

SuperPath

Contained pathways About

Amphetamine addiction

Cocaine addiction

0.44

Amphetamine addiction

0.44

Circadian entrainment

Glutamatergic synapse

0.39

Peptide ligand-binding receptors

Neuroactive ligand-receptor interaction

0.36

RNA Polymerase I Promoter Opening

Alcoholism

0.34

Amyotrophic lateral sclerosis (ALS)

Pathogenesis of ALS

0.31

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIN3A

	Pathogenesis of ALS
	Dopamine-DARPP32 Feedback onto cAMP Pathway

Selected Kegg Pathways (Kegg details for GRIN3A) (see all 6):

	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction

GRIN3A for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for GRIN3A
Interactions:

GeneGlobe Interaction Network for GRIN3A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for GRIN3A (Q8TCU5³ ENSP00000355155⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRIN1	Q05586³, ENSP00000360616⁴	I2D: score=2 STRING: ENSP00000360616
GRIN2A	Q12879³, ENSP00000332549⁴	I2D: score=1 STRING: ENSP00000332549
DYNLL1	P63167³	I2D: score=2
CEBPA	P49715³	I2D: score=1
DLG4	P78352³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0006816	calcium ion transport	ISS	--
GO:0016358	dendrite development	IEA	--
GO:0034220	ion transmembrane transport	IBA	--
GO:0035235	ionotropic glutamate receptor signaling pathway	IBA	--

GRIN3A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for GRIN3A available from Tocris Bioscience About this table

Compound	Action	CAS #
DL-AP5 Sodium salt	Sodium salt of DL-AP5 (Cat. No. 0105)	[1303993-72-7]
(+)-MK 801 maleate	Non-competitive NMDA antagonist, acts at ion channel site	[77086-22-7]
D-AP5	Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105)	[79055-68-8]
QNZ 46	NR2C/NR2D-selective NMDA receptor non-competitive antagonist	[1237744-13-6]
DL-AP5	Potent, selective NMDA antagonist	[76326-31-3]

4 HMDB Compounds for GRIN3A About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Dextromethorphan	Bayer Select Flu Relief (see all 58)	6700-34-1	--
Ethanol	1-Hydroxyethane (see all 57)	64-17-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

Selected DrugBank Compounds for GRIN3A (see all 18) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ethanol	Absolute Alcohol (see all 34)	64-17-5	target	antagonist	21163614 17139284 21204417 17016423 21289476 21204407
Dextromethorphan	D-Methorphan (see all 20)	125-71-3	target	antagonist	10064839 17139284 2897648 17016423 18812887
Memantine	Memantina [INN-Spanish] (see all 5)	19982-08-2	target	antagonist	16377242 11823786 14530799 16719808 17502428
Ethopropazine	Aethopropropazin (see all 25)	1094-08-2	target	antagonist	2849655 17139284 17016423 12681372
Ketamine	(-)-Ketamine (see all 7)	6740-88-1	target	antagonist	2858237 14740534 18175098 17502428
Procaine	--	59-46-1	target	antagonist	16299047 17139284 17016423 11812692
Methadone	(+/-)-Methadone (see all 8)	76-99-3	target	antagonist	17139284 17016423 19717013
Orphenadrine	Mephenamine (see all 7)	83-98-7	target	antagonist	17139284 17016423 8788072
Amantadine	1-aminoadamantane (see all 9)	768-94-5	target	antagonist	15800186 10443547
Chloroprocaine	Chloroprocain (see all 3)	133-16-4	target	antagonist	17139284 17016423

3 Novoseek inferred chemical compound relationships for GRIN3A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nmda	73.2	20	20016182 (2), 10366738 (2), 17617428 (2), 7472413 (2) (see all 13)
glutamate	42.4	3	19665356 (1), 11823786 (1), 17214563 (1)
calcium	0	1	18296432 (1)

GRIN3A for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for GRIN3A gene:

NM_133445.2

Unigene Cluster for GRIN3A:

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

Hs.654783 [show with all ESTs]

Unigene Representative Sequence: BC167432

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361820(uc004bbo.2 uc004bbp.2 uc004bbq.1) ENST00000479772

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat GRIN3A using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate GRIN3A (see all 67):
		hsa-miR-3678-3p hsa-miR-4254 hsa-miR-376b hsa-miR-300 hsa-miR-200a hsa-miR-3148 hsa-miR-2113 hsa-miR-3688-3p

		SwitchGear 3'UTR luciferase reporter plasmid: GRIN3A 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: GRIN3A (NM_133445)
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		QuantiTect SYBR Green Assays in human, mouse, rat GRIN3A
		QuantiFast Probe-based Assays in human, mouse, rat GRIN3A

Additional mRNA sequence:

AB075853.1 AF416558.1 AJ416950.2 AK125562.1 AK127342.1 AL137422.1 AL359651.1 BC029757.1

BC132866.1 BC132868.1 BC167432.1

5 DOTS entries:

DT.303624 DT.101980616 DT.91659709 DT.101958359 DT.75138664

20 AceView cDNA sequences:

NM_133445 BX282046 AB075853 AL137422 Z40440 BC029757 BF791640 Z44549

AL359651 F05465 BX643290 AJ416950 AK127342 BF969398 AW166288 AF416558

BQ930853 R61128 AI613310 AW956215

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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GRIN3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GATGGATTAG

About this image

GRIN3A expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Neural Tube (Nervous System) fully expand to see all 4 entries
Metencephalon

Brain (Nervous System) fully expand to see all 2 entries
Medulla Oblongata
Oligodendrocyte progenitor cells

Heart (Cardiovascular System)
Atrioventricular Node Cells Atrioventricular Node

Bone (Muscoskeletal System)
Autopod Long Bone

Spinal Cord (Nervous System)
Oligodendrocyte progenitor cells

GRIN3A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

GRIN3A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654783

Custom PCR Arrays for GRIN3A

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for GRIN3A
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat GRIN3A
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		QuantiFast Probe-based Assays in human, mouse, rat GRIN3A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN3A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for GRIN3A gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Grin3a^{1 , 5}	glutamate receptor ionotropic, NMDA3A^{1, 5}	89.21(n)¹ 93.36(a)¹		4 (26.72 cM)⁵ 242443¹ NM_001033351.2¹ NP_001028523.1¹ 49661611⁵
chicken (Gallus gallus)	Aves	GRIN3A¹	glutamate receptor, ionotropic, N-methyl-D-aspartate more	77.21(n) 83.35(a)		769001 XM_001232181.3 XP_001232182.2
lizard (Anolis carolinensis)	Reptilia	GRIN3A⁶	glutamate receptor, ionotropic, N-methyl-D-asparta...	79(a)	1 ↔ 1	2(64717580-64924025)
tropical clawed frog (Xenopus tropicalis)	Amphibia	grin3a¹	glutamate receptor, ionotropic, N-methyl-D-aspartate more	70.72(n) 78.2(a)		100486849 XM_002938539.2 XP_002938585.2
zebrafish (Danio rerio)	Actinopterygii	GRIN3A⁶	glutamate receptor, ionotropic, N-methyl-D-asparta...	62(a)	1 ↔ 1	10(4511584-4547733) ENSDARG00000075802
fruit fly (Drosophila melanogaster)	Insecta	Nmdar2⁶	NMDA receptor 2	21(a)	1 → many	X(1380259-1401842)
worm (Caenorhabditis elegans)	Secernentea	nmr-2⁶	Protein NMR-2, isoform a	23(a)	1 → many	V(15005938-15011660) WBGene00003775

ENSEMBL Gene Tree for GRIN3A (if available)
TreeFam Gene Tree for GRIN3A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for GRIN3A gene

GRIN2C² GRIN1² GRIN2B² GRIN2D² GRIN2A² GRIN3B²

2 SIMAP similar genes for GRIN3A using alignment to 2 protein entries: NMD3A_HUMAN (see all proteins):

GRIN3B GRIK3

GRIN3A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111920292^1,2	C,F	--	104331142(+)	`TCGGGC/TGGGAG`	1	--	ds500¹		4		WA NA CSA	8
rs184741334^1,2	C	--	104331227(+)	`CCTGGC/TGACAG`	1	--	ds500¹		0	--	--	--	--
rs369410080^1,2	C	--	104331268(+)	`AAAAA-/GAAAAA`	1	--	ds500¹		0	--	--	--	--
rs140150244^1,2		--	104331310(+)	`TTCACA/TATTGT`	1	--	ds500¹		0	--	--	--	--
rs112814301^1,2	C,F	--	104331517(+)	`CTTTGG/AACTAT`	1	--	ds500¹		1		NA	2
rs191372094^1,2		--	104331555(+)	`ATTAAC/TGGGTC`	1	--	ds500¹		0	--	--	--	--
rs184401905^1,2		--	104331676(+)	`AAACTA/GAAGAT`	1	--	ut3¹		0	--	--	--	--
rs189749412^1,2		--	104331720(+)	`TGGTTA/GTACAA`	1	--	ut3¹		0	--	--	--	--
rs150327631^1,2	C	--	104331736(+)	`GTGGCA/TGGAGC`	1	--	ut3¹		0	--	--	--	--
rs138018942^1,2		--	104331801(+)	`CGGAGC/TGATTG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for GRIN3A (104331634 - 104500862 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for GRIN3A (see all 17): About this table

Variant ID	Type	Subtype	PubMed ID
esv1035979	CNV	Deletion	17803354
esv2738843	CNV	Deletion	23290073
esv1995711	CNV	Deletion	18987734
esv2606620	CNV	Deletion	19546169
esv1003325	CNV	Deletion	20482838
esv3164	CNV	Deletion	18987735
esv991727	CNV	Deletion	20482838
esv2671974	CNV	Deletion	23128226
nsv6642	CNV	Loss	18451855
nsv415939	CNV	Loss	16902084

Human Gene Mutation Database (HGMD): GRIN3A

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing GRIN3A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606650 OMIM disorders: --

17 diseases for GRIN3A:
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paine syndrome nicotine addiction nicotine dependence bipolar disorder

esophageal squamous cell carcinoma hiv-1 osteosarcoma esophagitis

squamous cell carcinoma neuroblastoma schizophrenia neuronitis

cerebritis alzheimer's disease obesity prostatitis

prostate cancer

GRIN3A for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): GRIN3A
Human Genome Epidemiology (HuGE) Navigator: GRIN3A (13 documents)

Export disorders for GRIN3A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for GRIN3A gene, integrated from 10 sources (see all 117):
(articles sorted by number of sources associating them with GRIN3A)

Utopia: connect your pdf to the dynamic
world of online information

Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene (GRIN3A) reveals no association with schizophrenia. (PubMed id 19665356)^{1, 4, 9} Shen Y.C....Chen C.H. (Schizophr. Res. 2009)
Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans. (PubMed id 17214563)^{1, 4, 9} Gallinat J....Winterer G. (J Cogn Neurosci 2007)
Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease. (PubMed id 20016182)^{1, 4, 9} Liu H.P....Tsai F.J. (Dement Geriatr Cogn Disord 2009)
Cloning and expression of the human NMDA receptor subunit NR3A. (PubMed id 11880201)^{1, 2, 9} Eriksson M.... Sundstroem E. (Neurosci. Lett. 2002)
Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. (PubMed id 11735224)^{1, 2, 9} Andersson O.... von Euler G. (Genomics 2001)
Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers. (PubMed id 20084518)^{1, 4} Ma J.Z....Li M.D. (Hum. Genet. 2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)^{1, 4} Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)^{1, 4} GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 116443	HGNC: 16767	AceView: GRIN3A	Ensembl:ENSG00000198785	euGenes: HUgn116443
ECgene: GRIN3A	Kegg: 116443	H-InvDB: GRIN3A

(According to HUGE)
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HUGE: KIAA1973

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for GRIN3A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for GRIN3A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for GRIN3A gene:
Search GeneIP for patents involving GRIN3A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GRIN3A Gene

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A

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GRIN3A Gene

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A

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