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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRIN3A Gene

protein-coding   GIFtS: 61
GCID: GC09M104331

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A1 2     N-Methyl-D-Aspartate Receptor Subtype 3A2 3
NR3A2 3 5     Glutamate [NMDA] Receptor Subunit 3A2
GluN3A2 3     Glutamate Receptor Ionotropic, NMDA 3A2
NMDAR-L2 3     KIAA19733
NMDAR3A2 3     

External Ids:    HGNC: 167671   Entrez Gene: 1164432   Ensembl: ENSG000001987857   OMIM: 6066505   UniProtKB: Q8TCU53   

Export aliases for GRIN3A gene to outside databases

Previous GC identifers: GC09M095131 GC09M096075 GC09M097789 GC09M099711 GC09M101411 GC09M103371 GC09M073932


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRIN3A Gene:
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of
glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous
system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout
mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by
modulating NMDA receptor activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIN3A Gene: 
GRIN3A (glutamate receptor, ionotropic, N-methyl-D-aspartate 3A) is a protein-coding gene. Diseases associated with GRIN3A include paine syndrome, and nicotine dependence, and among its related super-pathways are Amphetamine addiction and Circadian entrainment. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and identical protein binding. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5
Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low
calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in
the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)

summary for GRIN3A Gene:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.

Gene Wiki entry for GRIN3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRIN3A gene promoter:
         E2F-4   E2F-3a   E2F-5   NRSF form 1   E2F-2   NRSF form 2   CBF-B   E2F   E2F-1   CBF-A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIN3A promoter sequence
   Search SABiosciences Chromatin IP Primers for GRIN3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIN3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q31.1

GRIN3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN3A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M104331:  view genomic region     (about GC identifiers)

Start:
104,331,634 bp from pter      End:
104,500,862 bp from pter
Size:
169,229 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, NMDA 3A precursor  
Size: 1115 amino acids; 125465 Da
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with
GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when
NMDARs are stimulated by NMDA (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse,
postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the
presence of GRIN1 to be targeted at the plasma membrane (By similarity)
Developmental stage: Expressed in fetal brain
Sequence caution: Sequence=BAB85559.1; Type=Erroneous initiation;
Secondary accessions: B3DLF9 Q5VTR3 Q8TF29 Q8WXI6

Explore the universe of human proteins at neXtProt for GRIN3A: NX_Q8TCU5

Explore proteomics data for GRIN3A at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TCU5

  • GRIN3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    GRIN3A Protein Expression
    REFSEQ proteins: NP_597702.2  
    ENSEMBL proteins: 
     ENSP00000355155  

    Human Recombinant Protein Products for GRIN3A: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRIN3A 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane IDA17997397
    GO:0016021integral to membrane NAS11880201
    GO:0017146N-methyl-D-aspartate selective glutamate receptor complex IDA17997397
    GO:0030054cell junction IEA--

    GRIN3A for ontologies           About GeneDecksing



    GRIN3A Antibody Products: 
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    Cloud-Clone Corp. ELISAs for GRIN3A 
    Cloud-Clone Corp. CLIAs for GRIN3A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluN3A 
    Ionotropic glutamate receptors

    4 InterPro protein domains:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8TCU5

    ProtoNet protein and cluster: Q8TCU5

    2 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature


    UniProtKB/Swiss-Prot: NMD3A_HUMAN, Q8TCU5
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily


    GRIN3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMD3A_HUMAN, Q8TCU5
    Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low
    calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in
    the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004972contributes to N-methyl-D-aspartate selective glutamate receptor activity ISS--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IEA--
    GO:0005262calcium channel activity IEA--
         
    GRIN3A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grin3a):
     behavior/neurological  nervous system  normal  vision/eye 

    GRIN3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRIN3A: Grin3atm1Nnk Grin3atm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRIN3A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for GRIN3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIN3A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIN3A 

    miRNA
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    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate GRIN3A (see all 67):
    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-376b hsa-miR-300 hsa-miR-200a hsa-miR-3148 hsa-miR-2113 hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIN3A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of GRIN3A 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN3A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRIN3A About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Amphetamine addiction0.44
    Cocaine addiction0.44
    2Circadian entrainment
    Glutamatergic synapse0.39
    3Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37
    4Alcoholism
    Alcoholism0.34
    5Pathogenesis of ALS
    Pathogenesis of ALS0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for GRIN3A
        Glutamic acid signaling

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIN3A
        Pathogenesis of ALS
    Dopamine-DARPP32 Feedback onto cAMP Pathway


    5/6         Kegg Pathways  (Kegg details for GRIN3A) (see all 6):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse
    Cocaine addiction
    Amphetamine addiction
    Nicotine addiction


    GRIN3A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIN3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for GRIN3A (Q8TCU53 ENSP000003551554) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    GRIN2AQ128793, ENSP000003325494I2D: score=1 STRING: ENSP00000332549
    GRIN2BQ132243, ENSP000002795934I2D: score=1 STRING: ENSP00000279593
    DYNLL1P631673I2D: score=2 
    CEBPAP497153I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006816calcium ion transport ISS--
    GO:0016358dendrite development IEA--
    GO:0035235ionotropic glutamate receptor signaling pathway ----
    GO:0045471response to ethanol IDA17502428

    GRIN3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRIN3A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRIN3A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DL-AP5 Sodium saltSodium salt of DL-AP5 (Cat. No. 0105)[1303993-72-7]
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    QNZ 46NR2C/NR2D-selective NMDA receptor non-competitive antagonist[1237744-13-6]
    DL-AP5 Potent, selective NMDA antagonist [76326-31-3]

    4 HMDB Compounds for GRIN3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DextromethorphanBayer Select Flu Relief (see all 58)6700-34-1--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/18 DrugBank Compounds for GRIN3A (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EthanolAbsolute Alcohol (see all 34)64-17-5targetantagonist21163614 17139284 21204417 17016423 21289476 21204407
    DextromethorphanD-Methorphan (see all 20)125-71-3targetantagonist10064839 17139284 2897648 17016423 18812887
    MemantineMemantina [INN-Spanish] (see all 5)19982-08-2targetantagonist16377242 11823786 14530799 16719808 17502428
    EthopropazineAethopropropazin (see all 25)1094-08-2targetantagonist2849655 17139284 17016423 12681372
    Ketamine(-)-Ketamine (see all 7)6740-88-1targetantagonist2858237 14740534 18175098 17502428
    Procaine-- 59-46-1targetantagonist16299047 17139284 17016423 11812692
    Methadone(+/-)-Methadone (see all 8)76-99-3targetantagonist17139284 17016423 19717013
    OrphenadrineMephenamine (see all 7)83-98-7targetantagonist17139284 17016423 8788072
    Amantadine1-aminoadamantane (see all 9)768-94-5targetantagonist15800186 10443547
    ChloroprocaineChloroprocain (see all 3)133-16-4targetantagonist17139284 17016423

    3 Novoseek inferred chemical compound relationships for GRIN3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 73.2 20 20016182 (2), 10366738 (2), 17617428 (2), 7472413 (2) (see all 13)
    glutamate 42.4 3 19665356 (1), 11823786 (1), 17214563 (1)
    calcium 0 1 18296432 (1)

    Search CenterWatch for drugs/clinical trials and news about GRIN3A / NMD3A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRIN3A gene: 
    NM_133445.2  

    Unigene Cluster for GRIN3A:

    Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
    Hs.654783  [show with all ESTs]
    Unigene Representative Sequence: BC167432
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361820(uc004bbo.2 uc004bbp.2 uc004bbq.1) ENST00000479772

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-376b hsa-miR-300 hsa-miR-200a hsa-miR-3148 hsa-miR-2113 hsa-miR-3688-3p
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIN3A

    Additional mRNA sequence: 

    AB075853.1 AF416558.1 AJ416950.2 AK125562.1 AK127342.1 AL137422.1 AL359651.1 BC029757.1 
    BC132866.1 BC132868.1 BC167432.1 

    5 DOTS entries:

    DT.303624  DT.101980616  DT.91659709  DT.101958359  DT.75138664 

    20 AceView cDNA sequences:

    BC029757 BX282046 Z44549 F05465 AB075853 NM_133445 BX643290 Z40440 
    AL359651 BF791640 AL137422 AJ416950 AF416558 BF969398 AK127342 AW166288 
    R61128 BQ930853 AW956215 AI613310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRIN3A expression in normal human tissues (normalized intensities)      GRIN3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGATTAG
    GRIN3A Expression
    About this image


    GRIN3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             brain/midbrain/lateral wall   
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Bone (Muscoskeletal System)
             Autopod Long Bone

    See GRIN3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRIN3A

    SOURCE GeneReport for Unigene cluster: Hs.654783
        SABiosciences Custom PCR Arrays for GRIN3A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRIN3A gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grin3a1 , 5 glutamate receptor ionotropic, NMDA3A1, 5 89.21(n)1
    93.36(a)1
      4 (26.72 cM)5
    2424431  NM_001033351.11  NP_001028523.11 
     496616115 
    chicken
    (Gallus gallus)
    Aves GRIN3A1 glutamate receptor, ionotropic, N-methyl-D-aspartate more 77.36(n)
    83.53(a)
      769001  XM_001232181.2  XP_001232182.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIN3A6
    Uncharacterized protein
    79(a)
    1 ↔ 1
    2(64717580-64924025)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5664111 glutamate [NMDA] receptor subunit 3A-like 61.96(n)
    62.26(a)
      566411  XM_689680.4  XP_694772.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ir8a6
    Ir25a6
    Ionotropic receptor 25a
    13(a)
    12(a)
    possible ortholog
    possible ortholog
    X(9126759-9130618)
    2L(4830846-4835300)
    worm
    (Caenorhabditis elegans)
    Secernentea glr-76
    Protein GLR-7
    18(a)
    possible ortholog
    X(2413909-2417892)


    ENSEMBL Gene Tree for GRIN3A (if available)
    TreeFam Gene Tree for GRIN3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRIN3A gene
    GRIA32  GRIN2D2  GRIK12  GRIA22  GRIN12  GRIK22  GRIA12  GRIK42  
    GRIK32  GRIN2B2  GRIN2A2  GRIK52  GRIN3B2  GRIA42  GRIN2C2  GRID12  
    GRID22  
    2 SIMAP similar genes for GRIN3A using alignment to 2 protein entries:     NMD3A_HUMAN (see all proteins):
    GRIN3B    GRIK3

    GRIN3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3413 SNPs in GRIN3A are shown (see all 3413)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119202921,2
    C,F--104331142(+) TCGGGC/TGGGAG 1 -- ds50014Minor allele frequency- T:0.50WA NA CSA 8
    rs1847413341,2
    C--104331227(+) CCTGGC/TGACAG 1 -- ds50010--------
    rs3694100801,2
    C--104331268(+) AAAAA-/GAAAAA 1 -- ds50010--------
    rs1401502441,2
    --104331310(+) TTCACA/TATTGT 1 -- ds50010--------
    rs1128143011,2
    C,F--104331517(+) CTTTGG/AACTAT 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1913720941,2
    --104331555(+) ATTAAC/TGGGTC 1 -- ds50010--------
    rs1844019051,2
    --104331676(+) AAACTA/GAAGAT 1 -- ut310--------
    rs1897494121,2
    --104331720(+) TGGTTA/GTACAA 1 -- ut310--------
    rs1503276311,2
    C--104331736(+) GTGGCA/TGGAGC 1 -- ut310--------
    rs1380189421,2
    --104331801(+) CGGAGC/TGATTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GRIN3A (104331634 - 104500862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for GRIN3A (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1035979CNV Deletion17803354
    esv2738843CNV Deletion23290073
    esv1995711CNV Deletion18987734
    esv2606620CNV Deletion19546169
    esv1003325CNV Deletion20482838
    esv3164CNV Deletion18987735
    esv991727CNV Deletion20482838
    esv2671974CNV Deletion23128226
    nsv6642CNV Loss18451855
    nsv415939CNV Loss16902084


    Human Gene Mutation Database (HGMD): GRIN3A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606650    OMIM disorders: --

    15 diseases for GRIN3A:    About MalaCards
    paine syndrome    nicotine dependence    hiv type 1    bipolar disorder
    osteosarcoma    esophageal squamous cell carcinoma    neuroblastoma    schizophrenia
    cerebritis    neuronitis    esophagitis    alzheimer's disease
    squamous cell carcinoma    prostate cancer    prostatitis


    GRIN3A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): GRIN3A
    Human Genome Epidemiology (HuGE) Navigator: GRIN3A (13 documents)

    Export disorders for GRIN3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRIN3A gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with GRIN3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exomic sequencing of the glutamate receptor, ionotrop ic, N-methyl-d-aspartate 3A gene (GRIN3A) reveals no association with schizophr enia. (PubMed id 19665356)1, 4, 9 Shen Y.C....Chen C.H. (2009)
    2. Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans. (PubMed id 17214563)1, 4, 9 Gallinat J....Winterer G. (2007)
    3. Genetic variation in N-methyl-D-aspartate receptor su bunit NR3A but not NR3B influences susceptibility to Alzheimer's disease. (PubMed id 20016182)1, 4, 9 Liu H.P....Tsai F.J. (2009)
    4. Cloning and expression of the human NMDA receptor subunit NR3A. (PubMed id 11880201)1, 2, 9 Eriksson M.... Sundstroem E. (2002)
    5. Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. (PubMed id 11735224)1, 2, 9 Andersson O.... von Euler G. (2001)
    6. Significant association of glutamate receptor, ionotr opic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- an d African-American smokers. (PubMed id 20084518)1, 4 Ma J.Z....Li M.D. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    10. Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. (PubMed id 19295509)1, 4 Perlis R.H....McMahon F.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116443 HGNC: 16767 AceView: GRIN3A Ensembl:ENSG00000198785 euGenes: HUgn116443
    ECgene: GRIN3A Kegg: 116443 H-InvDB: GRIN3A

    (According to HUGE)
    About This Section
    HUGE: KIAA1973

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRIN3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRIN3A gene:
    Search GeneIP for patents involving GRIN3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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