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GRIN3A Gene(Protein Coding)

Glutamate Ionotropic Receptor NMDA Type Subunit 3A

GCID:
GC09M101569
GIFtS:
58
Genes Participants
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Aliases for GRIN3A Gene

Aliases for GRIN3A Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit 3A 2 3
  • Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 3A 2 3 5
  • N-Methyl-D-Aspartate Receptor Subtype 3A 3 4
  • NMDAR-L 3 4
  • NMDAR3A 3 4
  • GluN3A 3 4
  • NR3A 3 4
  • Glutamate [NMDA] Receptor Subunit 3A 3
  • KIAA1973 4

External Ids for GRIN3A Gene

Previous GeneCards Identifiers for GRIN3A Gene

  • GC09M095131
  • GC09M096075
  • GC09M097789
  • GC09M099711
  • GC09M101411
  • GC09M103371
  • GC09M104331
  • GC09M073932

Summaries for GRIN3A Gene

Entrez Gene Summary for GRIN3A Gene

  • This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for GRIN3A Gene

GRIN3A (Glutamate Ionotropic Receptor NMDA Type Subunit 3A) is a Protein Coding gene. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia. Among its related pathways are cAMP signaling pathway and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include identical protein binding and protein phosphatase 2A binding. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot for GRIN3A Gene

  • NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).

Tocris Summary for GRIN3A Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.

Gene Wiki entry for GRIN3A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN3A Gene

Genomics for GRIN3A Gene

Products:

  1. Regulatory Element

Regulatory Elements for GRIN3A Gene

Enhancers for GRIN3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRIN3A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the GRIN3A gene promoter:

Genomic Location for GRIN3A Gene

Chromosome:
9
Start:
101,569,352 bp from pter
End:
101,738,580 bp from pter
Size:
169,229 bases
Orientation:
Minus strand

Genomic View for GRIN3A Gene

Genes around GRIN3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIN3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIN3A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GRIN3A Gene

Proteins for GRIN3A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GRIN3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCU5-NMD3A_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, NMDA 3A
    Protein Accession:
    Q8TCU5
    Secondary Accessions:
    • B3DLF9
    • Q5VTR3
    • Q8TF29
    • Q8WXI6

    Protein attributes for GRIN3A Gene

    Size:
    1115 amino acids
    Molecular mass:
    125465 Da
    Quaternary structure:
    • Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).
    SequenceCaution:
    • Sequence=BAB85559.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GRIN3A Gene

Proteomics data for GRIN3A Gene at MOPED

Post-translational modifications for GRIN3A Gene

  • N-glycosylated.
  • Glycosylation at Asn 145, Asn 264, Asn 275, Asn 285, Asn 296, Asn 426, Asn 439, Asn 549, Asn 565, and Asn 886
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIN3A Gene

Domains & Families for GRIN3A Gene

Gene Families for GRIN3A Gene

HGNC:
IUPHAR :

Protein Domains for GRIN3A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GRIN3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCU5

UniProtKB/Swiss-Prot:

NMD3A_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily.
genes like me logo Genes that share domains with GRIN3A: view

Function for GRIN3A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for GRIN3A Gene

UniProtKB/Swiss-Prot Function:
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).

Gene Ontology (GO) - Molecular Function for GRIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17658481
genes like me logo Genes that share ontologies with GRIN3A: view

Phenotypes for GRIN3A Gene

MGI mutant phenotypes for GRIN3A:
inferred from 2 alleles
GenomeRNAi human phenotypes for GRIN3A:
genes like me logo Genes that share phenotypes with GRIN3A: view

Animal Models for GRIN3A Gene

MGI Knock Outs for GRIN3A:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRIN3A

CRISPR Products

miRNA for GRIN3A Gene

miRTarBase miRNAs that target GRIN3A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIN3A Gene

Localization for GRIN3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN3A Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIN3A Gene COMPARTMENTS Subcellular localization image for GRIN3A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA,IDA 17997397
GO:0016021 integral component of membrane NAS 11880201
GO:0043005 neuron projection IDA 17658481
GO:0045202 synapse IDA 17658481
genes like me logo Genes that share ontologies with GRIN3A: view

Pathways & Interactions for GRIN3A Gene

genes like me logo Genes that share pathways with GRIN3A: view

Pathways by source for GRIN3A Gene

Gene Ontology (GO) - Biological Process for GRIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA,ISS --
GO:0016358 dendrite development IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIN3A: view

No data available for SIGNOR curated interactions for GRIN3A Gene

Drugs & Compounds for GRIN3A Gene

Products:

  1. Drug

(46) Drugs for GRIN3A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acamprosate Approved, Investigational Pharma agonist, Target, antagonist 38
Dextromethorphan Approved Pharma agonist, Target, antagonist 125
Felbamate Approved Pharma antagonist, Target 4
Memantine Approved, Investigational Pharma Channel blocker, antagonist, Target 173
Orphenadrine Approved Pharma antagonist, Target 7

(3) Additional Compounds for GRIN3A Gene - From: Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
trifluoroacetic acid
  • Acide trifluoroacetique
  • CF3COOH
  • Kyselina trifluoroctova
  • Perfluoroacetic acid
  • Trifluoracetic acid
 76-05-1
cis-ACPD
477331-06-9

(5) Tocris Compounds for GRIN3A Gene

Compound Action Cas Number
cis-ACPD Potent NMDA agonist. Also group II mGluR agonist 477331-06-9
D-Aspartic acid NMDA agonist 1783-96-6
Homoquinolinic acid Selective, potent NMDA agonist 490-75-5
L-Aspartic acid NMDA agonist 56-84-8
NMDA Selective NMDA agonist 6384-92-5

(2) ApexBio Compounds for GRIN3A Gene

Compound Action Cas Number
(+)-MK 801 Potent NMDA antagonist 70449-94-4
MK-801 (Dizocilpine) 77086-21-6
genes like me logo Genes that share compounds with GRIN3A: view

Transcripts for GRIN3A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for GRIN3A Gene

(3) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIN3A Gene

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN3A Gene

No ASD Table

Relevant External Links for GRIN3A Gene

GeneLoc Exon Structure for
GRIN3A
ECgene alternative splicing isoforms for
GRIN3A

Expression for GRIN3A Gene

Products:

  1. Primer

mRNA expression in normal human tissues for GRIN3A Gene

mRNA expression in normal human tissues for GRIN3A Gene
mRNA expression by BioGPS for GRIN3A GenemRNA expression by GTEx for GRIN3A Gene

mRNA differential expression in normal tissues according to GTEx for GRIN3A Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x8.5), Brain - Hypothalamus (x5.3), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Cortex (x4.7).

SOURCE GeneReport for Unigene cluster for GRIN3A Gene Hs.654783

genes like me logo Genes that share expression patterns with GRIN3A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GRIN3A Gene

Orthologs for GRIN3A Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GRIN3A 35
  • 92.1 (n)
  • 93.72 (a)
GRIN3A 36
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GRIN3A 35
  • 92.94 (n)
  • 94.98 (a)
GRIN3A 36
  • 95 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Grin3a 35
  • 89.21 (n)
  • 93.36 (a)
Grin3a 16
Grin3a 36
  • 93 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GRIN3A 35
  • 98.98 (n)
  • 99.1 (a)
GRIN3A 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Grin3a 35
  • 88.76 (n)
  • 92.65 (a)
oppossum
(Monodelphis domestica)
 Mammalia GRIN3A 36
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia GRIN3A 36
  • 86 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GRIN3A 35
  • 77.21 (n)
  • 83.35 (a)
GRIN3A 36
  • 83 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GRIN3A 36
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia grin3a 35
  • 70.72 (n)
  • 78.2 (a)
zebrafish
(Danio rerio)
 Actinopterygii GRIN3A 36
  • 62 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Nmdar2 36
  • 21 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea nmr-2 36
  • 23 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 31 (a)
 OneToMany
Species with no ortholog for GRIN3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIN3A Gene

ENSEMBL:
Gene Tree for GRIN3A (if available)
TreeFam:
Gene Tree for GRIN3A (if available)

Paralogs for GRIN3A Gene

Paralogs for GRIN3A Gene

(2) SIMAP similar genes for GRIN3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIN3A: view

Variants for GRIN3A Gene

Sequence variations from dbSNP and Humsavar for GRIN3A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10989591 - 101,686,816(+) CTCCA(A/C/T)ATTCT nc-transcript-variant, reference, missense
rs10989589 - 101,670,953(+) CTTTC(C/T)CCCCT nc-transcript-variant, reference, missense
rs10989563 - 101,623,429(+) TGGAT(C/T)ATTCC nc-transcript-variant, reference, missense
rs3739722 - 101,573,400(-) CATCC(A/G)GATCC reference, missense
rs34755188 - 101,670,973(+) CCAAG(C/T)GGGTC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GRIN3A Gene

Variant ID Type Subtype PubMed ID
nsv893627 CNV Loss 21882294
nsv831672 CNV Gain 17160897
nsv527229 CNV Loss 19592680
nsv6642 CNV Loss 18451855
nsv415939 CNV Loss 16902084
esv1003325 CNV Deletion 20482838
esv2606620 CNV Deletion 19546169
nsv512111 CNV Loss 21212237
esv1995711 CNV Deletion 18987734
esv2738843 CNV Deletion 23290073
esv3164 CNV Deletion 18987735
dgv266n6 CNV Loss 16902084
esv5546 CNV Loss 19470904
esv991727 CNV Deletion 20482838
esv1035979 CNV Deletion 17803354
esv2671974 CNV Deletion 23128226
esv26854 CNV Loss 19812545

Variation tolerance for GRIN3A Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.74; 99.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIN3A Gene

Human Gene Mutation Database (HGMD)
GRIN3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN3A Gene

Disorders for GRIN3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for GRIN3A Gene - From: DISEASES

Disorder Aliases PubMed IDs
lingual-facial-buccal dyskinesia
  • oro-facial dyskinesia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GRIN3A

Genetic Association Database (GAD)
GRIN3A
Human Genome Epidemiology (HuGE) Navigator
GRIN3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIN3A
genes like me logo Genes that share disorders with GRIN3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIN3A Gene

Publications for GRIN3A Gene

  1. Exomic sequencing of the ionotropic glutamate receptor N-methyl-D-aspartate 3A gene (GRIN3A) reveals no association with schizophrenia. (PMID: 19665356) Shen Y.C. … Chen C.H. (Schizophr. Res. 2009) 3 23 48 67
  2. Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. (PMID: 17502428) Smothers C.T. … Woodward J.J. (J. Pharmacol. Exp. Ther. 2007) 3 25 26
  3. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. (PMID: 11823786) Chatterton J.E. … Zhang D. (Nature 2002) 23 25 26
  4. Effects of ethanol on phosphorylation site mutants of recombinant N-methyl-D-aspartate receptors. (PMID: 21163614) Xu M. … Woodward J.J. (Alcohol 2011) 25 26
  5. Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. (PMID: 21289476) Wang J. … Ron D. (Channels (Austin) 2011) 25 26

Products for GRIN3A Gene

Sources for GRIN3A Gene

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