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Aliases for GRIN2D Gene

Aliases for GRIN2D Gene

  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D 2 3
  • Glutamate [NMDA] Receptor Subunit Epsilon-4 3 4
  • N-Methyl-D-Aspartate Receptor Subunit 2D 2 3
  • N-Methyl D-Aspartate Receptor Subtype 2D 3 4
  • NMDAR2D 3 4
  • GluN2D 3 4
  • EB11 3 4
  • NR2D 3 4
  • Estrogen Receptor Binding CpG Island 3

External Ids for GRIN2D Gene

Previous HGNC Symbols for GRIN2D Gene


Previous GeneCards Identifiers for GRIN2D Gene

  • GC19P049542
  • GC19P049266
  • GC19P053574
  • GC19P053589
  • GC19P048898
  • GC19P045278

Summaries for GRIN2D Gene

Entrez Gene Summary for GRIN2D Gene

  • N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

GeneCards Summary for GRIN2D Gene

GRIN2D (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include ionotropic glutamate receptor activity and NMDA glutamate receptor activity. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot for GRIN2D Gene

  • NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine

Tocris Summary for GRIN2D Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.

Gene Wiki entry for GRIN2D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN2D Gene

Genomics for GRIN2D Gene

Regulatory Elements for GRIN2D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRIN2D Gene

48,394,875 bp from pter
48,444,937 bp from pter
50,063 bases
Plus strand

Genomic View for GRIN2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIN2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN2D Gene

Proteins for GRIN2D Gene

  • Protein details for GRIN2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamate receptor ionotropic, NMDA 2D
    Protein Accession:

    Protein attributes for GRIN2D Gene

    1336 amino acids
    Molecular mass:
    143752 Da
    Quaternary structure:
    • Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).

neXtProt entry for GRIN2D Gene

Proteomics data for GRIN2D Gene at MOPED

Post-translational modifications for GRIN2D Gene

  • Ubiquitination at Lys 795 and Lys 1157
  • Glycosylation at Asn 92, Asn 352, Asn 366, Asn 467, and Asn 569
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN2D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GRIN2D Gene

Domains & Families for GRIN2D Gene

Gene Families for GRIN2D Gene

Suggested Antigen Peptide Sequences for GRIN2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
genes like me logo Genes that share domains with GRIN2D: view

Function for GRIN2D Gene

Molecular function for GRIN2D Gene

GENATLAS Biochemistry:
N-methyl D-aspartate receptor 2,delta subunit glutamate receptor,predominantly expressed,in diencephalic structures,mesenphalic dopaminergic neurons and in basal ganglia,involved in excitatory neurotransmission and in neuronal cell death,playing a central role in verbal memory and cognitive function
UniProtKB/Swiss-Prot Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine

Gene Ontology (GO) - Molecular Function for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004972 NMDA glutamate receptor activity IBA --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding IPI 11937501
genes like me logo Genes that share ontologies with GRIN2D: view
genes like me logo Genes that share phenotypes with GRIN2D: view

Animal Models for GRIN2D Gene

MGI Knock Outs for GRIN2D:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIN2D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GRIN2D Gene

Localization for GRIN2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN2D Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRIN2D Gene COMPARTMENTS Subcellular localization image for GRIN2D gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0017146 NMDA selective glutamate receptor complex IBA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIN2D: view

Pathways & Interactions for GRIN2D Gene

SuperPathways for GRIN2D Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Post NMDA receptor activation events
3 Transmission across Chemical Synapses
4 Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with GRIN2D: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001964 startle response IEA --
GO:0007165 signal transduction NAS 9480759
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GRIN2D: view

No data available for SIGNOR curated interactions for GRIN2D Gene

Drugs & Compounds for GRIN2D Gene

(63) Drugs for GRIN2D Gene - From: IUPHAR, DGIdb, HMDB, NovoSeek, DrugBank, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orphenadrine Approved Pharma antagonist, Target 6
Glycine Approved Nutra Agonist, antagonist Endogenous potentiator, co-transmitter 102
Ketamine Approved Pharma Channel blocker, antagonist 416
Meperidine Approved Pharma Target, antagonist 59
Acamprosate Approved, Investigational Pharma Target, antagonist 38

(8) Additional Compounds for GRIN2D Gene - From: IUPHAR, Tocris, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Channel blocker
7-Chlorokynurenic acid
genes like me logo Genes that share compounds with GRIN2D: view

Transcripts for GRIN2D Gene

mRNA/cDNA for GRIN2D Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIN2D Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate 2D:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIN2D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2: -

Relevant External Links for GRIN2D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRIN2D Gene

mRNA expression in normal human tissues for GRIN2D Gene

mRNA differential expression in normal tissues according to GTEx for GRIN2D Gene

This gene is overexpressed in Brain - Hypothalamus (x5.2).

Protein differential expression in normal tissues from HIPED for GRIN2D Gene

This gene is overexpressed in Plasma (42.9) and Pancreatic juice (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIN2D Gene

SOURCE GeneReport for Unigene cluster for GRIN2D Gene Hs.445015

genes like me logo Genes that share expression patterns with GRIN2D: view

Protein tissue co-expression partners for GRIN2D Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRIN2D Gene

Orthologs for GRIN2D Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN2D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRIN2D 35
  • 91.76 (n)
  • 98.26 (a)
  • 96 (a)
(Canis familiaris)
Mammalia GRIN2D 35
  • 93.27 (n)
  • 98.04 (a)
  • 98 (a)
(Mus musculus)
Mammalia Grin2d 35
  • 89.1 (n)
  • 97.25 (a)
Grin2d 16
Grin2d 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Grin2d 35
  • 88.67 (n)
  • 96.64 (a)
(Monodelphis domestica)
Mammalia GRIN2D 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia GRIN2D 36
  • 82 (a)
(Anolis carolinensis)
Reptilia GRIN2D 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grin2d 35
  • 64.15 (n)
  • 69.48 (a)
(Danio rerio)
Actinopterygii grin2da 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmdar2 37
  • 31 (a)
Nmdar2 35
  • 50.48 (n)
  • 34.29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012429 35
  • 43.19 (n)
  • 35.08 (a)
(Caenorhabditis elegans)
Secernentea nmr-2 35
  • 42.04 (n)
  • 33.2 (a)
Species with no ortholog for GRIN2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIN2D Gene

Gene Tree for GRIN2D (if available)
Gene Tree for GRIN2D (if available)

Paralogs for GRIN2D Gene

Paralogs for GRIN2D Gene

(5) SIMAP similar genes for GRIN2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRIN2D: view

Variants for GRIN2D Gene

Sequence variations from dbSNP and Humsavar for GRIN2D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs157067 -- 48,416,891(-) ggtgc(A/G)tgcct intron-variant
rs166718 -- 48,421,372(+) gcagt(A/G)agctg intron-variant
rs175773 -- 48,421,359(+) ggagg(C/T)ggagg intron-variant
rs276706 -- 48,421,148(-) cccag(A/C)cAACT intron-variant
rs276707 -- 48,420,718(-) ctccc(A/G)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIN2D Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv34181 CNV Loss 18971310
nsv833854 CNV Loss 17160897
nsv912219 CNV Loss 21882294
esv23564 CNV Gain 19812545
nsv828572 CNV Loss 20364138
esv2671636 CNV Deletion 23128226
nsv912220 CNV Loss 21882294
nsv912221 CNV Loss 21882294
nsv912222 CNV Loss 21882294
esv25255 CNV Loss 19812545

Variation tolerance for GRIN2D Gene

Residual Variation Intolerance Score: 4.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIN2D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN2D Gene

Disorders for GRIN2D Gene

Relevant External Links for GRIN2D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRIN2D: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIN2D Gene

Publications for GRIN2D Gene

  1. Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PMID: 9480759) Kalsi G. … Gurling H. (Genomics 1998) 2 23 67
  2. Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies. (PMID: 20153313) Sedaghati M. … Zarrindast M.R. (Eur. J. Pharmacol. 2010) 23 67
  3. Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. (PMID: 19651169) Bullock W.M. … Perrone-Bizzozero N.I. (Neurochem. Int. 2009) 23 67
  4. Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia. (PMID: 18462708) Dracheva S. … Haroutunian V. (Brain Res. 2008) 23 67
  5. Lack of functional expression of NMDA receptors in PC12 cells. (PMID: 17572500) Edwards M.A. … Phillips J.K. (Neurotoxicology 2007) 23 67

Products for GRIN2D Gene

Sources for GRIN2D Gene

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