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Aliases for GRIN2D Gene

Aliases for GRIN2D Gene

  • Glutamate Ionotropic Receptor NMDA Type Subunit 2D 2 3 5
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D 2 3
  • Glutamate [NMDA] Receptor Subunit Epsilon-4 3 4
  • N-Methyl-D-Aspartate Receptor Subunit 2D 2 3
  • N-Methyl D-Aspartate Receptor Subtype 2D 3 4
  • NMDAR2D 3 4
  • GluN2D 3 4
  • EB11 3 4
  • NR2D 3 4
  • Glutamate Receptor Ionotropic, NMDA 2D 3
  • Estrogen Receptor Binding CpG Island 3
  • EIEE46 3

External Ids for GRIN2D Gene

Previous HGNC Symbols for GRIN2D Gene


Previous GeneCards Identifiers for GRIN2D Gene

  • GC19P049542
  • GC19P049266
  • GC19P053574
  • GC19P053589
  • GC19P048898
  • GC19P045278

Summaries for GRIN2D Gene

Entrez Gene Summary for GRIN2D Gene

  • N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

GeneCards Summary for GRIN2D Gene

GRIN2D (Glutamate Ionotropic Receptor NMDA Type Subunit 2D) is a Protein Coding gene. Diseases associated with GRIN2D include Epileptic Encephalopathy, Early Infantile, 46 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are RET signaling and Protein-protein interactions at synapses. GO annotations related to this gene include ionotropic glutamate receptor activity and NMDA glutamate receptor activity. An important paralog of this gene is GRIN2C.

UniProtKB/Swiss-Prot for GRIN2D Gene

  • NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Tocris Summary for GRIN2D Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.

Gene Wiki entry for GRIN2D Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN2D Gene

Genomics for GRIN2D Gene

Regulatory Elements for GRIN2D Gene

Enhancers for GRIN2D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048418 1.2 Ensembl ENCODE 12.9 +24.2 24150 1.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B ETS1 ZNF766 GATA2 ZNF207 ZNF143 GRIN2D SYNGR4 TMEM143 KDELR1 GRWD1
GH19G048328 1.7 FANTOM5 ENCODE dbSUPER 5.5 -63.2 -63210 5.8 CREB3L1 AGO1 FEZF1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TMEM143 BICRA GRWD1 CA11 C19orf68 SYNGR4 NOP53-AS1 EMP3 RASIP1 SLC8A2
GH19G048500 1.6 Ensembl ENCODE dbSUPER 5.4 +106.8 106770 2.5 HDGF PKNOX1 FOXA2 ARNT AGO1 ARID4B ZNF207 ZNF263 SP3 MCM3 CYTH2 GRIN2D ENSG00000269814 GC19P048479
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRIN2D on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIN2D Gene

48,394,875 bp from pter
48,444,937 bp from pter
50,063 bases
Plus strand

Genomic View for GRIN2D Gene

Genes around GRIN2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIN2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIN2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN2D Gene

Proteins for GRIN2D Gene

  • Protein details for GRIN2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamate receptor ionotropic, NMDA 2D
    Protein Accession:

    Protein attributes for GRIN2D Gene

    1336 amino acids
    Molecular mass:
    143752 Da
    Quaternary structure:
    • Interacts with PDZ domains of PATJ and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).

neXtProt entry for GRIN2D Gene

Post-translational modifications for GRIN2D Gene

  • Ubiquitination at isoforms=795 and posLast=11571157
  • Glycosylation at isoforms=92, posLast=352352, posLast=366366, posLast=467467, and posLast=569569
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN2D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIN2D Gene

Domains & Families for GRIN2D Gene

Gene Families for GRIN2D Gene

Suggested Antigen Peptide Sequences for GRIN2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
genes like me logo Genes that share domains with GRIN2D: view

Function for GRIN2D Gene

Molecular function for GRIN2D Gene

GENATLAS Biochemistry:
N-methyl D-aspartate receptor 2,delta subunit glutamate receptor,predominantly expressed,in diencephalic structures,mesenphalic dopaminergic neurons and in basal ganglia,involved in excitatory neurotransmission and in neuronal cell death,playing a central role in verbal memory and cognitive function
UniProtKB/Swiss-Prot Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Gene Ontology (GO) - Molecular Function for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0004970 ionotropic glutamate receptor activity IDA 27616483
GO:0004972 NMDA glutamate receptor activity IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005216 ion channel activity IEA --
genes like me logo Genes that share ontologies with GRIN2D: view
genes like me logo Genes that share phenotypes with GRIN2D: view

Animal Models for GRIN2D Gene

MGI Knock Outs for GRIN2D:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIN2D Gene

Localization for GRIN2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN2D Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIN2D gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIN2D: view

Pathways & Interactions for GRIN2D Gene

SuperPathways for GRIN2D Gene

SuperPathway Contained pathways
1 RET signaling
2 Post NMDA receptor activation events
3 Transmission across Chemical Synapses
4 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
5 Amphetamine addiction
genes like me logo Genes that share pathways with GRIN2D: view

Gene Ontology (GO) - Biological Process for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001964 startle response IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction NAS 9480759
genes like me logo Genes that share ontologies with GRIN2D: view

No data available for SIGNOR curated interactions for GRIN2D Gene

Drugs & Compounds for GRIN2D Gene

(65) Drugs for GRIN2D Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orphenadrine Approved Pharma antagonist, Target 9
Meperidine Approved Pharma Target, antagonist 75
Ketamine Approved, Vet_approved Pharma Channel blocker, antagonist 569
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, antagonist 232
Acamprosate Approved, Investigational Pharma Target, antagonist 39

(6) Additional Compounds for GRIN2D Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Channel blocker
cis-6-Hydroxynorketamine hydrochloride
PEAQX tetrasodium salt

(5) Tocris Compounds for GRIN2D Gene

Compound Action Cas Number
cis-6-Hydroxynorketamine hydrochloride Metabolite of ketamine (Cat.No. 3131); antidepressive
D-AP5 Potent, selective NMDA antagonist; more active form of DL-AP5 (Cat. No. 0105) 79055-68-8
DL-AP5 Potent, selective NMDA antagonist 76326-31-3
DL-AP5 Sodium salt Sodium salt of DL-AP5 (Cat. No. 0105) 1303993-72-7
PEAQX tetrasodium salt Potent NMDA receptor antagonist; NR2A selective

(3) ApexBio Compounds for GRIN2D Gene

Compound Action Cas Number
(-)-Huperzine A NMDA receptor antagonist/AChE inhibitor 102518-79-6
(+)-MK 801 Potent NMDA antagonist 70449-94-4
MK-801 (Dizocilpine) 77086-21-6
genes like me logo Genes that share compounds with GRIN2D: view

Drug Products

Transcripts for GRIN2D Gene

mRNA/cDNA for GRIN2D Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIN2D Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate 2D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2: -

Relevant External Links for GRIN2D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRIN2D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIN2D Gene

mRNA differential expression in normal tissues according to GTEx for GRIN2D Gene

This gene is overexpressed in Brain - Hypothalamus (x5.2).

Protein differential expression in normal tissues from HIPED for GRIN2D Gene

This gene is overexpressed in Plasma (42.9) and Pancreatic juice (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIN2D Gene

Protein tissue co-expression partners for GRIN2D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIN2D Gene:


SOURCE GeneReport for Unigene cluster for GRIN2D Gene:


Evidence on tissue expression from TISSUES for GRIN2D Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with GRIN2D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIN2D Gene

Orthologs for GRIN2D Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN2D Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GRIN2D 34 35
  • 93.27 (n)
(Bos Taurus)
Mammalia GRIN2D 34 35
  • 91.76 (n)
(Mus musculus)
Mammalia Grin2d 34 16 35
  • 89.1 (n)
(Monodelphis domestica)
Mammalia GRIN2D 35
  • 89 (a)
(Rattus norvegicus)
Mammalia Grin2d 34
  • 88.67 (n)
(Ornithorhynchus anatinus)
Mammalia GRIN2D 35
  • 82 (a)
(Anolis carolinensis)
Reptilia GRIN2D 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grin2d 34
  • 64.15 (n)
(Danio rerio)
Actinopterygii grin2da 35
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmdar2 36 34
  • 50.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012429 34
  • 43.19 (n)
(Caenorhabditis elegans)
Secernentea nmr-2 34
  • 42.04 (n)
Species where no ortholog for GRIN2D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIN2D Gene

Gene Tree for GRIN2D (if available)
Gene Tree for GRIN2D (if available)

Paralogs for GRIN2D Gene

Paralogs for GRIN2D Gene

(5) SIMAP similar genes for GRIN2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRIN2D: view

Variants for GRIN2D Gene

Sequence variations from dbSNP and Humsavar for GRIN2D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035698 A breast cancer sample
VAR_035699 A breast cancer sample
VAR_035700 A breast cancer sample
VAR_077103 Epileptic encephalopathy, early infantile, 46 (EIEE46) [MIM:617162]
rs886040861 Pathogenic 48,419,722(+) TCGCC(A/G)TCATC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GRIN2D Gene

Variant ID Type Subtype PubMed ID
esv23564 CNV gain 19812545
esv25255 CNV loss 19812545
esv2671636 CNV deletion 23128226
esv34181 CNV loss 18971310
esv3644587 CNV loss 21293372
nsv1072889 CNV deletion 25765185
nsv1126526 CNV deletion 24896259
nsv828572 CNV loss 20364138
nsv833854 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for GRIN2D Gene

Residual Variation Intolerance Score: 4.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIN2D Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN2D Gene

Disorders for GRIN2D Gene

MalaCards: The human disease database

(3) MalaCards diseases for GRIN2D Gene - From: ClinVar, Orphanet, Swiss-Prot, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 46
  • eiee46
undetermined early-onset epileptic encephalopathy
  • undetermined eoee
myofascial pain syndrome
  • myofascial pain dysfunction syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Epileptic encephalopathy, early infantile, 46 (EIEE46) [MIM:617162]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. {ECO:0000269 PubMed:27616483}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for GRIN2D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRIN2D: view

No data available for Genatlas for GRIN2D Gene

Publications for GRIN2D Gene

  1. Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia. (PMID: 16094258) Makino C. … Fukumaki Y. (Psychiatr. Genet. 2005) 3 22 46 64
  2. Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PMID: 9480759) Kalsi G. … Gurling H. (Genomics 1998) 2 3 22 64
  3. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. (PMID: 27616483) Li D. … Falk M.J. (Am. J. Hum. Genet. 2016) 3 4 64
  4. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PMID: 19125103) Arai S. … Fukumaki Y. (Psychiatr. Genet. 2009) 3 46 64
  5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 46 64

Products for GRIN2D Gene

Sources for GRIN2D Gene

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