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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRIN2D Gene

protein-coding   GIFtS: 64
GCID: GC19P048898

glutamate receptor, ionotropic, N-methyl D-aspartate 2D


(Previous symbol: NMDAR2D)
 Explore 16 diseases affiliated with
GRIN2D via our new
 Human Malady Compendium 
Biological research products
for GRIN2D
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D1 2     Glutamate [NMDA] Receptor Subunit Epsilon-42 3
NMDAR2D1 2 3 5     N-Methyl D-Aspartate Receptor Subtype 2D2 3
EB111 2 3     Estrogen Receptor Binding CpG Island2
GluN2D1 2 3     Glutamate Receptor Ionotropic, NMDA 2D2
NR2D1 2 3     N-Methyl-D-Aspartate Receptor Subunit 2D2

External Ids:    HGNC: 45881   Entrez Gene: 29062   Ensembl: ENSG000001054647   OMIM: 6027175   UniProtKB: O153993   

Export aliases for GRIN2D gene to outside databases

Previous GC identifers: GC19P049542 GC19P049266 GC19P053574 GC19P053589 GC19P045278


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRIN2D:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be
involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought
to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor
subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C),
and NMDAR2D (GRIN2D). (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: NMDE4_HUMAN, O15399
Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent
sensitivity to magnesium. Mediated by glycine

summary for GRIN2D:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.

Gene Wiki entry for GRIN2D


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRIN2D gene promoter:
         Pax-5   p53   GATA-1   C/EBPalpha   PPAR-gamma1   FOXO1a   STAT3   SEF-1 (1)   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIN2D promoter sequence
   Search SABiosciences Chromatin IP Primers for GRIN2D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIN2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

GRIN2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN2D gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048898:  view genomic region     (about GC identifiers)

Start:
48,898,132 bp from pter      End:
48,948,188 bp from pter
Size:
50,057 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NMDE4_HUMAN, O15399 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, NMDA 2D precursor  
Size: 1336 amino acids; 143752 Da
Subunit: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit
(GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;
Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for GRIN2D: NX_O15399

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15399

  • GRIN2D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000827.2  
    ENSEMBL proteins: 
     ENSP00000263269  
    Reactome Protein details: O15399
    Human Recombinant Protein Products: 
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    Uscn Proteins for GRIN2D

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0017146N-methyl-D-aspartate selective glutamate receptor complex ----
    GO:0019717synaptosome ----
    GO:0030054cell junction IEA--


    GRIN2D for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for GRIN2D


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    GRIN2D for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry O15399

    ProtoNet protein and cluster: O15399

    3 Blocks protein families:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: NMDE4_HUMAN, O15399
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NMDE4_HUMAN, O15399
    Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent
    sensitivity to magnesium. Mediated by glycine

         Genatlas biochemistry entry for GRIN2D:
    N-methyl D-aspartate receptor 2,delta subunit glutamate receptor,predominantly expressed,in diencephalic
    structures,mesenphalic dopaminergic neurons and in basal ganglia,involved in excitatory neurotransmission and in
    neuronal cell death,playing a central role in verbal memory and cognitive function

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    hsa-miR-4328 hsa-miR-200a hsa-miR-128 hsa-miR-650 hsa-miR-941 hsa-miR-342-3p hsa-miR-141 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIN2D 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004972N-methyl-D-aspartate selective glutamate receptor activity IEA--
    GO:0005234extracellular-glutamate-gated ion channel activity IEA--
    GO:0005261cation channel activity ----
    GO:0016595glutamate binding ----


    GRIN2D for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Grin2dtm1Mim for GRIN2D
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grin2d):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism 
     integument  nervous system  skeleton 

    GRIN2D for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/21 super-pathways (see all 21About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CREB phosphorylation through the activation of CaMKII
    CREB phosphorylation through the activation of CaMKII1.00
    Unblocking of NMDA receptor, glutamate binding and activation0.68
    Ras activation uopn Ca2+ infux through NMDA receptor0.78
    2Post NMDA receptor activation events
    Post NMDA receptor activation events1.00
    CREB phosphorylation through the activation of Ras0.82
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.89
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses1.00
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling1.00
    Neurophysiological process_Glutamate regulation of Dopamine D1A receptor signaling0.98
    5Signal transduction Erk Interactions: Inhibition of Erk
    Signal transduction Erk Interactions: Inhibition of Erk1.00
    Signal transduction_Erk Interactions- Inhibition of Erk0.92

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for GRIN2D
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Glutamic acid signaling
    Signal transduction Erk Interactions- Inhibition of Erk
    Neurophysiological process PGE2-induced pain processing
    Calcium channels

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIN2D (see all 7)
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    Intracellular Calcium Signaling
    Huntington's Disease Pathway
    PEDF Induced Signaling

    3 GeneGo (Thomson Reuters) Pathways for GRIN2D
        Signal transduction Erk Interactions- Inhibition of Erk
    Neurophysiological process PGE2-induced pain processing
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    2 BioSystems Pathways for GRIN2D 
        Hypothetical Network for Drug Addiction
    Alzheimers Disease

    5/9        Reactome Pathways for GRIN2D (see all 9)
        Ras activation uopn Ca2+ infux through NMDA receptor
    Unblocking of NMDA receptor, glutamate binding and activation
    CREB phosphorylation through the activation of CaMKII
    Transmission across Chemical Synapses
    CREB phosphorylation through the activation of Ras


    5/6         Kegg Pathways  (Kegg details for GRIN2D) (see all 6):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Long-term potentiation
    Glutamatergic synapse
    Alzheimer's disease


    GRIN2D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIN2D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for GRIN2D (O153992, 3 ENSP000002632694) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783522, 3, ENSP000002938134MINT-1901005 I2D: score=6 STRING: ENSP00000293813
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    IL16Q140053, ENSP000003029354I2D: score=3 STRING: ENSP00000302935
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    INADLQ8NI353, ENSP000003602004I2D: score=2 STRING: ENSP00000360200
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001964startle response IEA--
    GO:0007165signal transduction NAS9480759
    GO:0007268synaptic transmission TAS--
    GO:0008344adult locomotory behavior IEA--
    GO:0035249synaptic transmission, glutamatergic ----


    GRIN2D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRIN2D for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRIN2D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    PPDASubtype-selective NR2C/NR2D antagonist--
    SDZ 220-581Competitive NMDA antagonist[174575-17-8]
    L-701,324 NMDA antagonist, acts glycine site [142326-59-8]

    3 HMDB Compounds for GRIN2D    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    LoperamideApo-Loperamide (see all 10)53179-11-6--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 DrugBank Compounds for GRIN2D    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423 8886398 11755246 9417820
    OrphenadrineMephenamine (see all 7)83-98-7targetantagonist17139284 17016423 8788072
    Meperidine-- 57-42-1targetantagonist10735801
    Tenocyclidine-- 21500-98-1targetantagonist2538766

    3 Novoseek chemical compound relationships for GRIN2D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 77.2 16 20153313 (2), 10648872 (1), 11334999 (1), 16094258 (1) (see all 14)
    glutamate 56.3 2 8915584 (1), 8027771 (1)
    kainate 51.1 2 11334999 (1), 18462708 (1)

    Search CenterWatch for drugs/clinical trials and news about GRIN2D / NMDE4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for GRIN2D gene: 
    NM_000836.2  

    Unigene Cluster for GRIN2D:

    Glutamate receptor, ionotropic, N-methyl D-aspartate 2D
    Hs.445015  [show with all ESTs]
    Unigene Representative Sequence: NM_000836
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263269(uc002pjc.4 uc010elx.3)

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    hsa-miR-4328 hsa-miR-200a hsa-miR-128 hsa-miR-650 hsa-miR-941 hsa-miR-342-3p hsa-miR-141 hsa-miR-3150b-3p
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIN2D

    Additional cDNA sequence: 

    AB209292.1 U77783.1 

    2 DOTS entries:

    DT.203006  DT.40122117 

    13 AceView cDNA sequences:

    BM551231 NM_000836 BF940611 BF512067 U77783 BF732431 BF507689 AW629560 
    AI565972 BF196280 BE903642 BM560376 BF941833 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2D    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                -                                             
    SP2:                                                              -               
    SP3:                                                                              


    ECgene alternative splicing isoforms for GRIN2D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRIN2D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTATGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See GRIN2D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for GRIN2D

    SOURCE GeneReport for Unigene cluster: Hs.445015
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRIN2D: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN2D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for GRIN2D gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia GRIN2D6
    --
    57(a)
    1 ↔ 1
    GL343279.1(1724800-1749734)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001494821 uncharacterized LOC100149482 66.28(n)
    70.03(a)
      100149482  XM_001921690.2  XP_001921725.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmdar21 , 3 N-methyl-D-aspartate selective glutamate
    receptor3
    NMDA receptor 21
    31(a)3
    50.09(n)1
    33.68(a)1
      2B13
    311071  NM_001014714.21  NP_001014714.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nmr-21 Protein NMR-2 42.3(n)
    32.97(a)
      180002  NM_074293.3  NP_506694.3 


    ENSEMBL Gene Tree for GRIN2D (if available)
    TreeFam Gene Tree for GRIN2D (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRIN2D gene
    GRIA32  GRIK12  GRIA22  GRIK22  GRIN12  GRIA12  GRIK32  GRIK42  
    GRIN3A2  GRIN2B2  GRIN2A2  GRIK52  GRIN3B2  GRIN2C2  GRIA42  GRID12  
    GRID22  
    5 SIMAP similar genes for GRIN2D using alignment to 1 protein entry:     NMDE4_HUMAN:
    GRIN2B    GRIN2A    NR2A    GRIN2C    NMDAR2C

    GRIN2D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/811 NCBI SNPs in GRIN2D are shown (see all 811    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422985981,2
    --48896181(+) GGGAA-/CCAGCC 2 -- us2k10--------
    rs2767181,2
    C,F,A,--48896205(-) ATAGAT/CGCAGG 2 -- us2k19Minor allele frequency- C:0.27MN NA WA CSA EA 551
    rs1113664291,2
    --48896222(+) ACAGAC/TGTGGC 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs730492411,2
    C,--48896237(+) CTTCCG/AGATGA 2 -- us2k12Minor allele frequency- A:0.14NA 122
    rs1913869311,2
    --48896242(+) GGATGA/GTGGGG 2 -- us2k10--------
    rs104089561,2
    C,F,--48896454(+) tgggtC/Tccagt 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1398247881,2
    --48896502(+) GGGGGG/TTGGGA 2 -- us2k10--------
    rs124596891,2
    C,F,H,--48896520(+) gaccaG/Cggtcg 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1855636801,2
    --48896765(+) TTCAGA/CCCCTC 2 -- us2k10--------
    rs1434456911,2
    --48896813(+) TAGGGA/GTGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIN2D (48898132 - 48948188 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for GRIN2D
         5 CNVs: 47965 5106 73397 73398 32261

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    DNA2.0 Custom Variant and Variant Library Synthesis for GRIN2D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    GRIN2D for disorders           About GeneDecksing

    OMIM gene information: 602717    OMIM disorders: --

    16 diseases for GRIN2D:    About MalaCards
    paine syndrome    amyotrophic lateral sclerosis (als)    amyotrophic lateral sclerosis    lateral sclerosis
    fibromyalgia    neuronitis    bipolar disorder    lung carcinoma
    retinoblastoma    neuroblastoma    schizophrenia    immunodeficiency
    thyroiditis    carcinoma    huntington's disease    hiv type 1

    1 disease from the University of Copenhagen DISEASES database for GRIN2D:
    Schizophrenia

    1 Novoseek disease relationship for GRIN2D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibromyalgia 40.4 1 16583480 (1)

    Genetic Association Database (GAD): GRIN2D
    Human Genome Epidemiology (HuGE) Navigator: GRIN2D (5 documents)

    Export disorders for GRIN2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRIN2D gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with GRIN2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia. (PubMed id 16094258)1, 4, 9 Makino C....Fukumaki Y. (2005)
    2. Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PubMed id 9480759)1, 3, 9 Kalsi G....Gurling H. (1998)
    3. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. (PubMed id 12082569)1, 4 Williams N.M....O'Donovan M.C. (2002)
    4. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. (PubMed id 9489750)1, 2 Hess S.D....Velicelebi G. (1998)
    5. Isolation of estrogen-responsive genes with a CpG island library. (PubMed id 9418891)1, 3 Watanabe T.... Muramatsu M. (1998)
    6. Cellular distribution of NMDA glutamate receptor subunit mRNAs in the human cerebellum. (PubMed id 9258910)1, 9 Scherzer C.R....Young A.B. (1997)
    7. Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport. (PubMed id 21948112)1 Mocchetti I....Avdoshina V. (2012)
    8. HIV immune complexes prevent excitotoxicity by interac tion with NMDA receptors. (PubMed id 22940423)1 Rumbaugh J.A....Nath A. (2012)
    9. D1/NMDA receptors and concurrent methamphetamine+HIV-1 Tat neurotoxicity. (PubMed id 22552781)1 Aksenov M.Y....Booze R.M. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2906 HGNC: 4588 AceView: GRIN2D Ensembl:ENSG00000105464 euGenes: HUgn2906
    ECgene: GRIN2D Kegg: 2906 H-InvDB: GRIN2D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRIN2D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRIN2D gene:
    Search GeneIP for patents involving GRIN2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

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