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GRIN2D Gene

protein-coding   GIFtS: 65
GCID: GC19P048898

Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D


(Previous symbol: NMDAR2D)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D1 2     GluN2D2 3
NMDAR2D1 2 3 5     NR2D2 3
N-Methyl-D-Aspartate Receptor Subunit 2D1 2     N-Methyl D-Aspartate Receptor Subtype 2D2 3
Glutamate [NMDA] Receptor Subunit Epsilon-42 3     Estrogen Receptor Binding CpG Island2
EB112 3     Glutamate Receptor Ionotropic, NMDA 2D2

External Ids:    HGNC: 45881   Entrez Gene: 29062   Ensembl: ENSG000001054647   OMIM: 6027175   UniProtKB: O153993   

Export aliases for GRIN2D gene to outside databases

Previous GC identifers: GC19P049542 GC19P049266 GC19P053574 GC19P053589 GC19P045278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIN2D Gene:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown
to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic
transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers
composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A),
NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). (provided by RefSeq, Mar 2010)

GeneCards Summary for GRIN2D Gene:
GRIN2D (glutamate receptor, ionotropic, N-methyl D-aspartate 2D) is a protein-coding gene. Diseases associated with GRIN2D include fibromyalgia, and paine syndrome. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and N-methyl-D-aspartate selective glutamate receptor activity. An important paralog of this gene is GRIN2C.

UniProtKB/Swiss-Prot: NMDE4_HUMAN, O15399
Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and
voltage-dependent sensitivity to magnesium. Mediated by glycine

summary for GRIN2D Gene:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.

Gene Wiki entry for GRIN2D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIN2D gene promoter:
         Pax-5   p53   GATA-1   C/EBPalpha   PPAR-gamma1   FOXO1a   STAT3   SEF-1 (1)   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIN2D promoter sequence
   Search Chromatin IP Primers for GRIN2D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIN2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

GRIN2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN2D gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048898:  view genomic region     (about GC identifiers)

Start:
48,898,132 bp from pter      End:
48,948,188 bp from pter
Size:
50,057 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NMDE4_HUMAN, O15399 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, NMDA 2D precursor  
Size: 1336 amino acids; 143752 Da
Subunit: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit
(GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B)

Explore the universe of human proteins at neXtProt for GRIN2D: NX_O15399

Explore proteomics data for GRIN2D at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys795, Lys1157
  • Glycosylation2 at Asn92, Asn352, Asn366, Asn467, Asn569
  • Modification sites at PhosphoSitePlus

  • See GRIN2D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000827.2  
    ENSEMBL proteins: 
     ENSP00000263269  
    Reactome Protein details: O15399

    GRIN2D Human Recombinant Protein Products:

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    OriGene Custom Protein Services for GRIN2D
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRIN2D

    GRIN2D Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIN2D
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    Novus Biologicals GRIN2D Antibodies
    Search for Antibodies for GRIN2D at Abcam
    Cloud-Clone Corp. Antibodies for GRIN2D
    Search ThermoFisher Antibodies for GRIN2D
    LSBio Antibodies in human, mouse, rat for GRIN2D

    GRIN2D Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRIN2D
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRIN2D
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRIN2D
    Cloud-Clone Corp. CLIAs for GRIN2D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluN2D
    Ionotropic glutamate receptors

    Selected InterPro protein domains (see all 6):
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt

    Graphical View of Domain Structure for InterPro Entry O15399

    ProtoNet protein and cluster: O15399

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: NMDE4_HUMAN, O15399
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily


    GRIN2D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMDE4_HUMAN, O15399
    Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and
    voltage-dependent sensitivity to magnesium. Mediated by glycine

         Genatlas biochemistry entry for GRIN2D:
    N-methyl D-aspartate receptor 2,delta subunit glutamate receptor,predominantly expressed,in diencephalic
    structures,mesenphalic dopaminergic neurons and in basal ganglia,involved in excitatory neurotransmission and in
    neuronal cell death,playing a central role in verbal memory and cognitive function

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004972N-methyl-D-aspartate selective glutamate receptor activity IBA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding IPI11937501
         
    GRIN2D for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grin2d):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism 
     integument  nervous system  skeleton 

    GRIN2D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grin2dtm1Mim for GRIN2D

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIN2D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIN2D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIN2D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIN2D

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRIN2D:
    hsa-mir-335-5p (MIRT017316)

    Block miRNA regulation of human, mouse, rat GRIN2D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIN2D (see all 36):
    hsa-miR-4328 hsa-miR-200a hsa-miR-128 hsa-miR-650 hsa-miR-941 hsa-miR-342-3p hsa-miR-141 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIN2D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRIN2D
    Predesigned siRNA for gene silencing in human, mouse, rat GRIN2D

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRIN2D

    Clone
    Products:
         
    OriGene clones in human, mouse for GRIN2D (see all 6)
    OriGene ORF clones in mouse, rat for GRIN2D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRIN2D (NM_000836)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIN2D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GRIN2D

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for GRIN2D
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRIN2D 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN2D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMDE4_HUMAN, O15399: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0017146N-methyl-D-aspartate selective glutamate receptor complex IBA--
    GO:0030054cell junction IEA--

    GRIN2D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIN2D About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Ras activation uopn Ca2+ infux through NMDA receptor0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    CREB phosphorylation through the activation of Ras0.78
    CREB phosphorylation through the activation of CaMKII0.00
    Long-term potentiation0.35
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    5Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIN2D (see all 7)
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    Intracellular Calcium Signaling
    Huntington's Disease Pathway
    PEDF Induced Signaling

    3 GeneGo (Thomson Reuters) Pathways for GRIN2D
        Signal transduction Erk Interactions- Inhibition of Erk
    Neurophysiological process PGE2-induced pain processing
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    2 BioSystems Pathways for GRIN2D
        Hypothetical Network for Drug Addiction
    Alzheimers Disease

    3 Reactome Pathways for GRIN2D
        Ras activation uopn Ca2+ infux through NMDA receptor
    Unblocking of NMDA receptor, glutamate binding and activation
    CREB phosphorylation through the activation of CaMKII


    Selected Kegg Pathways  (Kegg details for GRIN2D) (see all 11):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Circadian entrainment
    Long-term potentiation
    Glutamatergic synapse


    GRIN2D for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIN2D: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIN2D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIN2D (O153991, 2, 3 ENSP000002632694) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001964startle response IEA--
    GO:0006810transport ----
    GO:0007165signal transduction NAS9480759
    GO:0007268synaptic transmission TAS--
    GO:0008344adult locomotory behavior IEA--

    GRIN2D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIN2D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DL-AP5 Sodium saltSodium salt of DL-AP5 (Cat. No. 0105)[1303993-72-7]
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    QNZ 46NR2C/NR2D-selective NMDA receptor non-competitive antagonist[1237744-13-6]
    DL-AP5 Potent, selective NMDA antagonist [76326-31-3]

    3 HMDB Compounds for GRIN2D    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    LoperamideApo-Loperamide (see all 10)53179-11-6--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 DrugBank Compounds for GRIN2D    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423 8886398 11755246 9417820
    OrphenadrineMephenamine (see all 7)83-98-7targetantagonist17139284 17016423 8788072
    Meperidine-- 57-42-1targetantagonist10735801
    Tenocyclidine-- 21500-98-1targetantagonist2538766

    Selected IUPHAR Ligands for GRIN2D (GluN2D) (see all 33)    About this table
    LigandTypeActionAffinityPubmed IDs
    phencyclidine
    Channel blockerNone--
    [3H]CGP39653
    NoneNone--
    LY233053
    AntagonistAntagonist--
    D-aspartate
    AgonistAgonist--
    L701324
    AntagonistAntagonist--
    glycine
    AgonistAgonist--
    Mg2+
    Channel blockerNone--
    MK-801
    Channel blockerNone--
    CGP37849
    AntagonistAntagonist--
    [3H]glycine
    NoneNone--

    3 Novoseek inferred chemical compound relationships for GRIN2D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 77.2 16 20153313 (2), 10648872 (1), 11334999 (1), 16094258 (1) (see all 14)
    glutamate 56.3 2 8915584 (1), 8027771 (1)
    kainate 51.1 2 11334999 (1), 18462708 (1)



    GRIN2D for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRIN2D gene: 
    NM_000836.2  

    Unigene Cluster for GRIN2D:

    Glutamate receptor, ionotropic, N-methyl D-aspartate 2D
    Hs.445015  [show with all ESTs]
    Unigene Representative Sequence: NM_000836
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263269(uc002pjc.4 uc010elx.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat GRIN2D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIN2D (see all 36):
    hsa-miR-4328 hsa-miR-200a hsa-miR-128 hsa-miR-650 hsa-miR-941 hsa-miR-342-3p hsa-miR-141 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIN2D 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat GRIN2D
    Clone
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    OriGene clones in human, mouse for GRIN2D (see all 6)
    OriGene ORF clones in mouse, rat for GRIN2D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRIN2D (NM_000836)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIN2D
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat GRIN2D
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIN2D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIN2D
      QuantiTect SYBR Green Assays in human, mouse, rat GRIN2D
      QuantiFast Probe-based Assays in human, mouse, rat GRIN2D

    Additional mRNA sequence: 

    AB209292.1 U77783.1 

    2 DOTS entries:

    DT.203006  DT.40122117 

    13 AceView cDNA sequences:

    BM551231 NM_000836 U77783 BF940611 BF512067 BF732431 AW629560 BF507689 
    BF196280 AI565972 BE903642 BM560376 BF941833 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2D    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                -                                             
    SP2:                                                              -               
    SP3:                                                                              


    ECgene alternative splicing isoforms for GRIN2D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    GRIN2D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTATGCC
    GRIN2D Expression
    About this image

    GRIN2D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIN2D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445015
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIN2D: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for GRIN2D gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grin2d1 , 5 glutamate receptor, ionotropic, NMDA2D (epsilon 4)1, 5 89.1(n)1
    97.25(a)1
      7 (29.54 cM)5
    148141  NM_008172.21  NP_032198.21 
     458318835 
    lizard
    (Anolis carolinensis)
    Reptilia GRIN2D6
    glutamate receptor, ionotropic, N-methyl D-asparta...
    60(a)
    1 ↔ 1
    GL343279.1(1724800-1774857)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grin2d1 glutamate receptor, ionotropic, N-methyl D-aspartate more 64.15(n)
    69.48(a)
      100496465  XM_002934986.2  XP_002935032.1 
    zebrafish
    (Danio rerio)
    Actinopterygii grin2da6
    glutamate receptor, ionotropic, N-methyl D-asparta...
    34(a)
    1 → many
    19(10536681-10703583) ENSDARG00000086207
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmdar21 , 3 N-methyl-D-aspartate selective
    glutamate receptor3
    NMDA receptor 21
    31(a)3
    50.48(n)1
    34.29(a)1
      2B13
    311071  NM_001169166.11  NP_001162637.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nmr-21 nmr-2 42.04(n)
    33.2(a)
      180002  NM_001269711.1  NP_001256640.1 


    ENSEMBL Gene Tree for GRIN2D (if available)
    TreeFam Gene Tree for GRIN2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIN2D gene
    GRIN2C2  GRIN12  GRIN3A2  GRIN2B2  GRIN2A2  GRIN3B2  
    5 SIMAP similar genes for GRIN2D using alignment to 1 protein entry:     NMDE4_HUMAN:
    GRIN2B    GRIN2A    NR2A    GRIN2C    NMDAR2C

    GRIN2D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIN2D (see all 999)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356984
    A breast cancer sample4--see VAR_0356982 P S mis40--------
    VAR_0357004
    A breast cancer sample4--see VAR_0357002 E G mis40--------
    VAR_0356994
    A breast cancer sample4--see VAR_0356992 G R mis40--------
    rs1434456911,2
    C--48896813(+) TAGGGA/GTGGGG 1 -- us2k10--------
    rs2767171,2
    C,F,H--48897243(+) GCTGCC/ATGCCT 1 -- us2k112Minor allele frequency- A:0.31MN NS EA NA CSA WA 1307
    rs1467512711,2
    --48897266(+) GCTCCC/TGCTCC 1 -- us2k10--------
    rs1147180191,2
    F--48897279(+) CCCCCC/GGGCCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1394389551,2
    C--48897286(+) GCCCCA/C/TCCAAA 1 -- us2k10--------
    rs1382883781,2
    --48897439(+) CACTC-/TGTGTGT 1 -- us2k10--------
    rs2767161,2
    C,F--48897512(+) GTGAGG/ATCGTG 1 -- us2k111Minor allele frequency- A:0.23NA WA CSA EA 371

    HapMap Linkage Disequilibrium report for GRIN2D (48898132 - 48948188 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIN2D (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671636CNV Deletion23128226
    nsv912220CNV Loss21882294
    nsv828572CNV Loss20364138
    nsv912222CNV Loss21882294
    nsv912221CNV Loss21882294
    nsv912219CNV Loss21882294
    nsv833854CNV Loss17160897
    esv25255CNV Loss19812545
    esv34181CNV Loss18971310
    esv23564CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602717    OMIM disorders: --

    19 diseases for GRIN2D:    About MalaCards
    fibromyalgia    paine syndrome    drug addiction    nicotine addiction
    hiv-1    lateral sclerosis    amyotrophic lateral sclerosis    bipolar disorder
    autism spectrum disorder    huntington's disease    neuronitis    breast and colorectal cancer
    retinoblastoma    schizophrenia    neuroblastoma    alzheimer's disease
    thyroiditis    malaria    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for GRIN2D:
    Schizophrenia

    GRIN2D for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for GRIN2D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibromyalgia 40.4 1 16583480 (1)

    Genetic Association Database (GAD): GRIN2D
    Human Genome Epidemiology (HuGE) Navigator: GRIN2D (5 documents)

    Export disorders for GRIN2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIN2D gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with GRIN2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia. (PubMed id 16094258)1, 4, 9 Makino C....Fukumaki Y. (Psychiatr. Genet. 2005)
    2. Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PubMed id 9480759)1, 3, 9 Kalsi G....Gurling H. (Genomics 1998)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PubMed id 19125103)1, 4 Arai S....Fukumaki Y. (Psychiatr. Genet. 2009)
    5. Neurotransmission and bipolar disorder: a systematic family-based association study. (PubMed id 18444252)1, 4 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    6. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. (PubMed id 12082569)1, 4 Williams N.M....O'Donovan M.C. (Mol. Psychiatry 2002)
    7. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. (PubMed id 9489750)1, 2 Hess S.D....Velicelebi G. (J. Neurochem. 1998)
    8. Isolation of estrogen-responsive genes with a CpG island library. (PubMed id 9418891)1, 3 Watanabe T.... Muramatsu M. (Mol. Cell. Biol. 1998)
    9. Cellular distribution of NMDA glutamate receptor subunit mRNAs in the human cerebellum. (PubMed id 9258910)1, 9 Scherzer C.R....Young A.B. (Neurobiol. Dis. 1997)
    10. Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. (PubMed id 23639431)1 Gautam V....Monaghan D.T. (Neuropharmacology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2906 HGNC: 4588 AceView: GRIN2D Ensembl:ENSG00000105464 euGenes: HUgn2906
    ECgene: GRIN2D Kegg: 2906 H-InvDB: GRIN2D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRIN2D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRIN2D gene:
    Search GeneIP for patents involving GRIN2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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