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Aliases for GRIN2D Gene

Aliases for GRIN2D Gene

  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D 2 3
  • NMDAR2D 3 4 6
  • Glutamate [NMDA] Receptor Subunit Epsilon-4 3 4
  • N-Methyl-D-Aspartate Receptor Subunit 2D 2 3
  • N-Methyl D-Aspartate Receptor Subtype 2D 3 4
  • GluN2D 3 4
  • EB11 3 4
  • NR2D 3 4
  • Glutamate Receptor Ionotropic, NMDA 2D 3
  • Estrogen Receptor Binding CpG Island 3

External Ids for GRIN2D Gene

Previous HGNC Symbols for GRIN2D Gene

  • NMDAR2D

Previous GeneCards Identifiers for GRIN2D Gene

  • GC19P049542
  • GC19P049266
  • GC19P053574
  • GC19P053589
  • GC19P048898
  • GC19P045278

Summaries for GRIN2D Gene

Entrez Gene Summary for GRIN2D Gene

  • N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

GeneCards Summary for GRIN2D Gene

GRIN2D (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D) is a Protein Coding gene. Among its related pathways are CREB Pathway and fMLP Pathway. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and N-methyl-D-aspartate selective glutamate receptor activity. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot for GRIN2D Gene

  • NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine

Tocris Summary for GRIN2D Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Gene Wiki entry for GRIN2D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN2D Gene

Genomics for GRIN2D Gene

Regulatory Elements for GRIN2D Gene

Genomic Location for GRIN2D Gene

Start:
48,394,875 bp from pter
End:
48,444,931 bp from pter
Size:
50,057 bases
Orientation:
Plus strand

Genomic View for GRIN2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIN2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN2D Gene

Proteins for GRIN2D Gene

  • Protein details for GRIN2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15399-NMDE4_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, NMDA 2D
    Protein Accession:
    O15399
    Secondary Accessions:

    Protein attributes for GRIN2D Gene

    Size:
    1336 amino acids
    Molecular mass:
    143752 Da
    Quaternary structure:
    • Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B).

neXtProt entry for GRIN2D Gene

Proteomics data for GRIN2D Gene at MOPED

Post-translational modifications for GRIN2D Gene

  • Ubiquitination at Lys795 and Lys1157
  • Glycosylation at Asn92, Asn352, Asn366, Asn467, and Asn569
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN2D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIN2D Gene

Domains for GRIN2D Gene

Gene Families for GRIN2D Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for GRIN2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15399

UniProtKB/Swiss-Prot:

NMDE4_HUMAN :
  • O15399
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.
genes like me logo Genes that share domains with GRIN2D: view

Function for GRIN2D Gene

Molecular function for GRIN2D Gene

GENATLAS Biochemistry: N-methyl D-aspartate receptor 2,delta subunit glutamate receptor,predominantly expressed,in diencephalic structures,mesenphalic dopaminergic neurons and in basal ganglia,involved in excitatory neurotransmission and in neuronal cell death,playing a central role in verbal memory and cognitive function
UniProtKB/Swiss-Prot Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine

Gene Ontology (GO) - Molecular Function for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity IBA --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding IPI 11937501
genes like me logo Genes that share ontologies with GRIN2D: view
genes like me logo Genes that share phenotypes with GRIN2D: view

Animal Models for GRIN2D Gene

MGI Knock Outs for GRIN2D:

miRNA for GRIN2D Gene

miRTarBase miRNAs that target GRIN2D

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRIN2D Gene

Localization for GRIN2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN2D Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIN2D Gene COMPARTMENTS Subcellular localization image for GRIN2D gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex IBA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with GRIN2D: view

Pathways for GRIN2D Gene

genes like me logo Genes that share pathways with GRIN2D: view

Gene Ontology (GO) - Biological Process for GRIN2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001964 startle response IEA --
GO:0007165 signal transduction NAS 9480759
GO:0007268 synaptic transmission TAS --
GO:0008344 adult locomotory behavior IEA --
GO:0034220 ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with GRIN2D: view

Compounds for GRIN2D Gene

(5) Tocris Compounds for GRIN2D Gene

Compound Action Cas Number
(+)-MK 801 maleate Non-competitive NMDA antagonist; acts at ion channel site [77086-22-7]
D-AP5 Potent, selective NMDA antagonist; more active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
DL-AP5 Potent, selective NMDA antagonist [76326-31-3]
DL-AP5 Sodium salt Sodium salt of DL-AP5 (Cat. No. 0105) [1303993-72-7]
Ro 25-6981 maleate Subtype-selective NR2B antagonist [1312991-76-6]

(3) HMDB Compounds for GRIN2D Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Loperamide
  • Apo-Loperamide
53179-11-6
Magnesium
  • Magnesium
7439-95-4

(4) Drugbank Compounds for GRIN2D Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
Meperidine
57-42-1 target antagonist
Orphenadrine
  • Mephenamine
83-98-7 target antagonist
Tenocyclidine
21500-98-1 target antagonist

(33) IUPHAR Ligand for GRIN2D Gene

Ligand Type Action Affinity Pubmed IDs
5,7-dichlorokynurenic acid Antagonist Antagonist 3.7
phencyclidine Channel blocker None
[3H]CGP39653 None None
LY233053 Antagonist Antagonist
D-aspartate Agonist Agonist
L701324 Antagonist Antagonist
glycine Agonist Agonist
Mg2+ Antagonist Antagonist
MK-801 Channel blocker None
CGP37849 Antagonist Antagonist
[3H]glycine None None
d-AP5 Antagonist Antagonist
(RS)-(tetrazol-5-yl)glycine Agonist Full agonist
[3H]CGS19755 None None
[3H]CGP61594 None None
[3H]CPP None None
L-aspartate Agonist Agonist
ketamine Channel blocker None
conantokin-G Antagonist Antagonist
CGS19755 Antagonist Antagonist
d-CCPene Antagonist Antagonist
D-serine Agonist Agonist
UBP141 Antagonist Antagonist
homoquinolinic acid Agonist Full agonist
[3H]MDL105519 None None
L689560 Antagonist Antagonist
memantine Channel blocker None
N1-dansyl-spermine Channel blocker None
amantidine Channel blocker None
NMDA Agonist Full agonist
[3H]L689560 None None
[3H]MK-801 None None
GV196771A Antagonist Antagonist

(3) Novoseek inferred chemical compound relationships for GRIN2D Gene

Compound -log(P) Hits PubMed IDs
nmda 77.2 15
glutamate 56.3 2
kainate 51.1 2
genes like me logo Genes that share compounds with GRIN2D: view

Transcripts for GRIN2D Gene

mRNA/cDNA for GRIN2D Gene

(13) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIN2D Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate 2D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: -
SP2: -
SP3:

Relevant External Links for GRIN2D Gene

GeneLoc Exon Structure for
GRIN2D
ECgene alternative splicing isoforms for
GRIN2D

Expression for GRIN2D Gene

mRNA expression in normal human tissues for GRIN2D Gene

mRNA differential expression in normal tissues according to GTEx for GRIN2D Gene

This gene is overexpressed in Brain - Hypothalamus (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIN2D Gene

SOURCE GeneReport for Unigene cluster for GRIN2D Gene Hs.445015

genes like me logo Genes that share expressions with GRIN2D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRIN2D Gene

Orthologs for GRIN2D Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN2D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRIN2D 35
  • 91.76 (n)
  • 98.26 (a)
GRIN2D 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIN2D 35
  • 93.27 (n)
  • 98.04 (a)
GRIN2D 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grin2d 35
  • 89.1 (n)
  • 97.25 (a)
Grin2d 16
Grin2d 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIN2D 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIN2D 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grin2d 35
  • 88.67 (n)
  • 96.64 (a)
lizard
(Anolis carolinensis)
Reptilia GRIN2D 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grin2d 35
  • 64.15 (n)
  • 69.48 (a)
zebrafish
(Danio rerio)
Actinopterygii grin2da 36
  • 34 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012429 35
  • 43.19 (n)
  • 35.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmdar2 35
  • 50.48 (n)
  • 34.29 (a)
Nmdar2 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea nmr-2 35
  • 42.04 (n)
  • 33.2 (a)
Species with no ortholog for GRIN2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIN2D Gene

ENSEMBL:
Gene Tree for GRIN2D (if available)
TreeFam:
Gene Tree for GRIN2D (if available)

Paralogs for GRIN2D Gene

Paralogs for GRIN2D Gene

Selected SIMAP similar genes for GRIN2D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GRIN2D: view

Variants for GRIN2D Gene

Sequence variations from dbSNP and Humsavar for GRIN2D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs157067 -- 48,416,891(-) ggtgc(A/G)tgcct intron-variant
rs166718 -- 48,421,372(+) gcagt(A/G)agctg intron-variant
rs175773 -- 48,421,359(+) ggagg(C/T)ggagg intron-variant
rs276706 -- 48,421,148(-) cccag(A/C)cAACT intron-variant
rs276707 -- 48,420,718(-) ctccc(A/G)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIN2D Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv34181 CNV Loss 18971310
nsv833854 CNV Loss 17160897
nsv912219 CNV Loss 21882294
esv23564 CNV Gain 19812545
nsv828572 CNV Loss 20364138
esv2671636 CNV Deletion 23128226
nsv912220 CNV Loss 21882294
nsv912221 CNV Loss 21882294
nsv912222 CNV Loss 21882294
esv25255 CNV Loss 19812545

Relevant External Links for GRIN2D Gene

HapMap Linkage Disequilibrium report
GRIN2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN2D Gene

Disorders for GRIN2D Gene

(1) University of Copenhagen DISEASES for GRIN2D Gene

(1) Novoseek inferred disease relationships for GRIN2D Gene

Disease -log(P) Hits PubMed IDs
fibromyalgia 40.4 1

Relevant External Links for GRIN2D

Genetic Association Database (GAD)
GRIN2D
Human Genome Epidemiology (HuGE) Navigator
GRIN2D
genes like me logo Genes that share disorders with GRIN2D: view

No data available for UniProtKB/Swiss-Prot for GRIN2D Gene

Publications for GRIN2D Gene

  1. Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PMID: 9480759) Kalsi G. … Gurling H. (Genomics 1998) 2 3 23
  2. Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia. (PMID: 16094258) Makino C. … Fukumaki Y. (Psychiatr. Genet. 2005) 3 23 48
  3. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors. (PMID: 9489750) Hess S.D. … Velicelebi G. (J. Neurochem. 1998) 3 4
  4. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. (PMID: 12082569) Williams N.M. … O'Donovan M.C. (Mol. Psychiatry 2002) 3 48
  5. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PMID: 19125103) Arai S. … Fukumaki Y. (Psychiatr. Genet. 2009) 3 48

Products for GRIN2D Gene

  • antibodies-online peptides for GRIN2D
  • antibodies-online antibodies for GRIN2D
  • antibodies-online kits for GRIN2D

Sources for GRIN2D Gene

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