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Aliases for GRIN2C Gene

Aliases for GRIN2C Gene

  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2C 2 3
  • Glutamate [NMDA] Receptor Subunit Epsilon-3 3 4
  • N-Methyl D-Aspartate Receptor Subtype 2C 3 4
  • NMDAR2C 3 4
  • GluN2C 3 4
  • NR2C 3 4
  • N-Methyl-D-Aspartate Receptor Subunit 2C 3

External Ids for GRIN2C Gene

Previous HGNC Symbols for GRIN2C Gene


Previous GeneCards Identifiers for GRIN2C Gene

  • GC17M072854
  • GC17M075896
  • GC17M073302
  • GC17M073435
  • GC17M070349
  • GC17M068248
  • GC17M072839

Summaries for GRIN2C Gene

Entrez Gene Summary for GRIN2C Gene

  • This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for GRIN2C Gene

GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2C) is a Protein Coding gene. Diseases associated with GRIN2C include schizophrenia and alzheimer disease. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include PDZ domain binding and cation channel activity. An important paralog of this gene is GRIN2A.

UniProtKB/Swiss-Prot for GRIN2C Gene

  • NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine

Tocris Summary for GRIN2C Gene

  • NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations.

Gene Wiki entry for GRIN2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIN2C Gene

Genomics for GRIN2C Gene

Regulatory Elements for GRIN2C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GRIN2C Gene

74,842,021 bp from pter
74,861,514 bp from pter
19,494 bases
Minus strand

Genomic View for GRIN2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIN2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIN2C Gene

Proteins for GRIN2C Gene

  • Protein details for GRIN2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamate receptor ionotropic, NMDA 2C
    Protein Accession:
    Secondary Accessions:
    • B2RTT1

    Protein attributes for GRIN2C Gene

    1233 amino acids
    Molecular mass:
    134209 Da
    Quaternary structure:
    • Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes.

neXtProt entry for GRIN2C Gene

Proteomics data for GRIN2C Gene at MOPED

Post-translational modifications for GRIN2C Gene

  • Glycosylation at Asn 70, Asn 337, Asn 438, and Asn 539
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIN2C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for GRIN2C (GRIN2C/NMDAR2C)

No data available for DME Specific Peptides for GRIN2C Gene

Domains & Families for GRIN2C Gene

Gene Families for GRIN2C Gene

Suggested Antigen Peptide Sequences for GRIN2C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
genes like me logo Genes that share domains with GRIN2C: view

Function for GRIN2C Gene

Molecular function for GRIN2C Gene

GENATLAS Biochemistry:
N-methyl D-aspartate receptor 3,epsilon 3 subunit glutamate receptor,expressed in brain,mainly in cerebellum,basal ganglia,heart,skeletal muscle,pancreas,involved in excitatory neurotransmission and in neuronal cell death,playing a central role in verbal memory and cognitive function
UniProtKB/Swiss-Prot Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine

Gene Ontology (GO) - Molecular Function for GRIN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0004972 NMDA glutamate receptor activity IEA --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005261 cation channel activity IEA --
GO:0005515 protein binding IPI 11937501
genes like me logo Genes that share ontologies with GRIN2C: view
genes like me logo Genes that share phenotypes with GRIN2C: view

Animal Models for GRIN2C Gene

MGI Knock Outs for GRIN2C:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIN2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for GRIN2C Gene

Localization for GRIN2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIN2C Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GRIN2C Gene COMPARTMENTS Subcellular localization image for GRIN2C gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9798920
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with GRIN2C: view

Pathways & Interactions for GRIN2C Gene

SuperPathways for GRIN2C Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Post NMDA receptor activation events
3 Transmission across Chemical Synapses
4 Circadian entrainment
5 Immune System
genes like me logo Genes that share pathways with GRIN2C: view

PCR Array Products

Gene Ontology (GO) - Biological Process for GRIN2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0006810 transport TAS 9798920
GO:0006812 cation transport --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with GRIN2C: view

No data available for SIGNOR curated interactions for GRIN2C Gene

Drugs & Compounds for GRIN2C Gene

(62) Drugs for GRIN2C Gene - From: IUPHAR, DGIdb, NovoSeek, HMDB, DrugBank, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Agonist, antagonist, Target Endogenous potentiator, co-transmitter 102
Ketamine Approved Pharma Channel blocker, antagonist 416
Meperidine Approved Pharma Target, antagonist 59
Acamprosate Approved, Investigational Pharma Target, antagonist 38
Atomoxetine Approved Pharma Target, blocker 159

(8) Additional Compounds for GRIN2C Gene - From: IUPHAR, Tocris, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Channel blocker
7-Chlorokynurenic acid
genes like me logo Genes that share compounds with GRIN2C: view

Transcripts for GRIN2C Gene

Unigene Clusters for GRIN2C Gene

Glutamate receptor, ionotropic, N-methyl D-aspartate 2C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIN2C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2C Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - - -
SP4: - -
SP5: - - - -

Relevant External Links for GRIN2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRIN2C Gene

mRNA expression in normal human tissues for GRIN2C Gene

mRNA differential expression in normal tissues according to GTEx for GRIN2C Gene

This gene is overexpressed in Brain - Cerebellum (x14.7) and Brain - Cerebellar Hemisphere (x12.9).

Protein differential expression in normal tissues from HIPED for GRIN2C Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIN2C Gene

SOURCE GeneReport for Unigene cluster for GRIN2C Gene Hs.436980

mRNA Expression by UniProt/SwissProt for GRIN2C Gene

Tissue specificity: Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas
genes like me logo Genes that share expression patterns with GRIN2C: view

Protein tissue co-expression partners for GRIN2C Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GRIN2C Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIN2C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRIN2C 35
  • 89.01 (n)
  • 89.83 (a)
  • 89 (a)
(Canis familiaris)
Mammalia GRIN2C 35
  • 92.76 (n)
  • 95.46 (a)
  • 91 (a)
(Mus musculus)
Mammalia Grin2c 35
  • 85.59 (n)
  • 89.23 (a)
Grin2c 16
Grin2c 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Grin2c 35
  • 86.11 (n)
  • 88.99 (a)
(Monodelphis domestica)
Mammalia GRIN2C 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
(Pan troglodytes)
Mammalia GRIN2C 36
  • 95 (a)
(Gallus gallus)
Aves GRIN2C 35
  • 80.67 (n)
  • 79.54 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia GRIN2C 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grin2c 35
  • 67.48 (n)
  • 69.32 (a)
(Danio rerio)
Actinopterygii LOC100333648 35
  • 70.38 (n)
  • 71.93 (a)
grin2ca 36
  • 50 (a)
grin2cb 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmdar2 37
  • 31 (a)
Species with no ortholog for GRIN2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIN2C Gene

Gene Tree for GRIN2C (if available)
Gene Tree for GRIN2C (if available)

Paralogs for GRIN2C Gene

Paralogs for GRIN2C Gene

(6) SIMAP similar genes for GRIN2C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GRIN2C: view

Variants for GRIN2C Gene

Sequence variations from dbSNP and Humsavar for GRIN2C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs472890 -- 74,855,246(-) CTCTC(C/T)GCCTC intron-variant, reference, synonymous-codon
rs534353 -- 74,853,217(-) CTGCG(C/G)TGGCC intron-variant
rs689730 -- 74,854,994(-) GTGGC(A/C/G/T)GTGGT reference, synonymous-codon, nc-transcript-variant
rs689782 -- 74,858,344(-) ACCCC(C/T)AACCC intron-variant, upstream-variant-2KB
rs689964 -- 74,855,289(-) CCTCT(A/G)TCTCT intron-variant, missense, reference

Structural Variations from Database of Genomic Variants (DGV) for GRIN2C Gene

Variant ID Type Subtype PubMed ID
nsv908743 CNV Loss 21882294
nsv518292 CNV Loss 19592680
nsv908744 CNV Loss 21882294
dgv3253n71 CNV Loss 21882294
nsv833540 CNV Loss 17160897
nsv519902 CNV Loss 19592680
dgv3254n71 CNV Loss 21882294

Variation tolerance for GRIN2C Gene

Residual Variation Intolerance Score: 81.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.06; 87.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIN2C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIN2C Gene

Disorders for GRIN2C Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRIN2C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • schizophrenia 12
alzheimer disease
  • alzheimer disease, late-onset
- elite association

Relevant External Links for GRIN2C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GRIN2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIN2C Gene

Publications for GRIN2C Gene

  1. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in vasopressin and oxytocin neuroendocrine cells. (PMID: 9073168) Al-Ghoul W.M. … Greenwood R.S. (Brain Res. Mol. Brain Res. 1997) 23 25 26 67
  2. Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PMID: 9480759) Kalsi G. … Gurling H. (Genomics 1998) 2 23 67
  3. Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia. (PMID: 18462708) Dracheva S. … Haroutunian V. (Brain Res. 2008) 23 67
  4. Lack of functional expression of NMDA receptors in PC12 cells. (PMID: 17572500) Edwards M.A. … Phillips J.K. (Neurotoxicology 2007) 23 67
  5. Quantitative single-cell RT-PCR and Ca2+ imaging in brain slices. (PMID: 16211366) Durand G.M. … Konnerth A. (Pflugers Arch. 2006) 23 67

Products for GRIN2C Gene

Sources for GRIN2C Gene

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