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GRIN2C Gene

protein-coding   GIFtS: 72
GCID: GC17M072839

Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2C


(Previous symbol: NMDAR2C)
  See GRIN2C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2C1 2     NR2C2 3
NMDAR2C1 2 3 5     N-Methyl D-Aspartate Receptor Subtype 2C2 3
Glutamate [NMDA] Receptor Subunit Epsilon-32 3     Glutamate Receptor Ionotropic, NMDA 2C2
GluN2C2 3     N-Methyl-D-Aspartate Receptor Subunit 2C2

External Ids:    HGNC: 45871   Entrez Gene: 29052   Ensembl: ENSG000001615097   OMIM: 1382545   UniProtKB: Q149573   

Export aliases for GRIN2C gene to outside databases

Previous GC identifers: GC17M072854 GC17M075896 GC17M073302 GC17M073435 GC17M070349 GC17M068248


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIN2C Gene:
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic
glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an
important role in physiological processes such as learning, memory, and synaptic development. The receptor is a
tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a
channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit
composition. Alterations in the subunit composition of the receptor are associated with pathophysiological
conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for GRIN2C Gene:
GRIN2C (glutamate receptor, ionotropic, N-methyl D-aspartate 2C) is a protein-coding gene. Diseases associated with GRIN2C include toxic encephalopathy, and schizophrenia. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and protein N-terminus binding. An important paralog of this gene is GRIN1.

UniProtKB/Swiss-Prot: NMDE3_HUMAN, Q14957
Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and
voltage-dependent sensitivity to magnesium. Mediated by glycine

summary for GRIN2C Gene:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.

Gene Wiki entry for GRIN2C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIN2C gene promoter:
         AREB6   USF1   USF-1   NRSF form 1   SEF-1 (1)   CUTL1   Tal-1beta   ITF-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIN2C promoter sequence
   Search Chromatin IP Primers for GRIN2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIN2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

GRIN2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN2C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M072839:  view genomic region     (about GC identifiers)

Start:
72,838,162 bp from pter      End:
72,857,627 bp from pter
Size:
19,466 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NMDE3_HUMAN, Q14957 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, NMDA 2C precursor  
Size: 1233 amino acids; 134209 Da
Subunit: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit
(GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Interacts
(via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma
membrane when endocytosed and prevent degradation in lysosomes
Secondary accessions: B2RTT1

Explore the universe of human proteins at neXtProt for GRIN2C: NX_Q14957

Explore proteomics data for GRIN2C at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn70, Asn337, Asn438, Asn539
  • Modification sites at PhosphoSitePlus

  • See GRIN2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000826.2  NP_001265482.1  

    ENSEMBL proteins: 
     ENSP00000293190   ENSP00000338645  
    Reactome Protein details: Q14957

    GRIN2C Human Recombinant Protein Products:

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    antibodies-online proteins for GRIN2C (2 products) 

     
    antibodies-online peptides for GRIN2C

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluN2C
    Ionotropic glutamate receptors

    Selected InterPro protein domains (see all 7):
     IPR018884 NMDAR2_C
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt

    Graphical View of Domain Structure for InterPro Entry Q14957

    ProtoNet protein and cluster: Q14957

    2 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature


    UniProtKB/Swiss-Prot: NMDE3_HUMAN, Q14957
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily


    Find genes that share domains with GRIN2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMDE3_HUMAN, Q14957
    Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and
    voltage-dependent sensitivity to magnesium. Mediated by glycine

         Genatlas biochemistry entry for GRIN2C:
    N-methyl D-aspartate receptor 3,epsilon 3 subunit glutamate receptor,expressed in brain,mainly in cerebellum,basal
    ganglia,heart,skeletal muscle,pancreas,involved in excitatory neurotransmission and in neuronal cell
    death,playing a central role in verbal memory and cognitive function

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004972N-methyl-D-aspartate selective glutamate receptor activity IBA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005261cation channel activity IEA--
         
    Find genes that share ontologies with GRIN2C           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for GRIN2C:
     Decreased DCP1a protein expres  Decreased TP53 protein express  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 
     Increased HPV18 LCR reporter a  Increased Salmonella enterica   Proliferating cells 

         3 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Grin2c):
     behavior/neurological  nervous system  normal 

    Find genes that share phenotypes with GRIN2C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for GRIN2C: Grin2ctm1Rsp Grin2ctm1Nts Grin2ctm2Rsp Grin2ctm1Mwa Grin2ctm1Nak

       genOway: Develop your customized and physiologically relevant rodent model for GRIN2C

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMDE3_HUMAN, Q14957: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    extracellular2
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9798920
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with GRIN2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIN2C About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Ras activation uopn Ca2+ infux through NMDA receptor0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    CREB phosphorylation through the activation of Ras0.78
    CREB phosphorylation through the activation of CaMKII0.00
    Long-term potentiation0.35
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    4Glutamic acid signaling
    Glutamic acid signaling
    Synaptic Neurotransmission: Glutamatergic Excitation0.00
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72


    Find genes that share SuperPaths with GRIN2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GRIN2C
        Synaptic Neurotransmission: Glutamatergic Excitation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIN2C (see all 7)
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    Intracellular Calcium Signaling
    Huntington's Disease Pathway
    PEDF Induced Signaling

    3 GeneGo (Thomson Reuters) Pathways for GRIN2C
        Signal transduction Erk Interactions- Inhibition of Erk
    Neurophysiological process PGE2-induced pain processing
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    2 BioSystems Pathways for GRIN2C
        Hypothetical Network for Drug Addiction
    Alzheimers Disease

    3 Reactome Pathways for GRIN2C
        Ras activation uopn Ca2+ infux through NMDA receptor
    Unblocking of NMDA receptor, glutamate binding and activation
    CREB phosphorylation through the activation of CaMKII


    Selected Kegg Pathways  (Kegg details for GRIN2C) (see all 11):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Circadian entrainment
    Long-term potentiation
    Glutamatergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIN2C: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GRIN2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GRIN2C (Q149571, 2, 3 ENSP000002931904) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783521, 2, 3EBI-8285963,EBI-80389 MINT-1900102 MINT-1900873 MINT-1901291 MINT-1901315 I2D: score=7 
    IL16Q140053, ENSP000003029354I2D: score=4 STRING: ENSP00000302935
    DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
    ERBB2IPQ96RT13, ENSP000003703304I2D: score=2 STRING: ENSP00000370330
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
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    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9798920
    GO:0007215glutamate receptor signaling pathway TAS9798920
    GO:0007268synaptic transmission TAS--
    GO:0008104protein localization IEA--
    GO:0009611response to wounding IEA--

    Find genes that share ontologies with GRIN2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for GRIN2C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DL-AP5 Sodium saltSodium salt of DL-AP5 (Cat. No. 0105)[1303993-72-7]
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    QNZ 46NR2C/NR2D-selective NMDA receptor non-competitive antagonist[1237744-13-6]
    DL-AP5 Potent, selective NMDA antagonist [76326-31-3]

    3 HMDB Compounds for GRIN2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    LoperamideApo-Loperamide (see all 10)53179-11-6--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 DrugBank Compounds for GRIN2C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17139284 11861317 9073168 8955518 17016423
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423 7905294 10455281 9417820
    Meperidine-- 57-42-1targetantagonist10735801
    Tenocyclidine-- 21500-98-1targetantagonist2538766

    Selected IUPHAR Ligands for GRIN2C (GluN2C) (see all 33)    About this table
    LigandTypeActionAffinityPubmed IDs
    phencyclidine
    Channel blockerNone--
    [3H]CGP39653
    NoneNone--
    LY233053
    AntagonistAntagonist--
    D-aspartate
    AgonistAgonist--
    L701324
    AntagonistAntagonist--
    glycine
    AgonistAgonist--
    Mg2+
    Channel blockerNone--
    MK-801
    Channel blockerNone--
    CGP37849
    AntagonistAntagonist--
    [3H]glycine
    NoneNone--

    4 Novoseek inferred chemical compound relationships for GRIN2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 76.9 26 16989781 (2), 16606616 (2), 10436042 (1), 9037519 (1) (see all 20)
    glutamate 59.1 3 16211366 (1), 11058479 (1), 8027771 (1)
    kainate 54.4 1 18462708 (1)
    magnesium 13.2 1 16372011 (1)



    Find genes that share compounds with GRIN2C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRIN2C gene (2 alternative transcripts): 
    NM_000835.4  NM_001278553.1  

    Unigene Cluster for GRIN2C:

    Glutamate receptor, ionotropic, N-methyl D-aspartate 2C
    Hs.436980  [show with all ESTs]
    Unigene Representative Sequence: AB208799
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293190(uc002jlt.1 uc010wrh.1) ENST00000584176(uc002jlv.1)
    ENST00000347612(uc002jlu.1) ENST00000578159 ENST00000584496
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    Additional mRNA sequence: 

    AB208799.1 BC031077.1 BC041128.1 BC059384.1 BC140801.1 BC144586.1 L76224.1 U77782.1 

    6 DOTS entries:

    DT.209713  DT.101964990  DT.40302770  DT.70100279  DT.95154273  DT.75139422 

    Selected AceView cDNA sequences (see all 39):

    BM665652 BC041128 BG150328 BX096031 BQ184546 CD672417 BM686026 AI825597 
    L76224 CD675565 BC059384 R88090 AI964061 BE466191 AL043138 BC031077 
    AW950843 BF594520 AI937054 NM_000835 U77782 BI598245 H49419 BI598195 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for GRIN2C    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
    SP1:                                -                                                     -                             -         
    SP2:              -     -           -                                                     -                                       
    SP3:                                                                                                                              
    SP4:              -     -                                                                                                         
    SP5:                          -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for GRIN2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIN2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    GRIN2C Expression
    About this image


    GRIN2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Thalamus
             cerebellum   
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
    GRIN2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIN2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436980

    UniProtKB/Swiss-Prot: NMDE3_HUMAN, Q14957
    Tissue specificity: Mainly expressed in brain with predominant expression is in the cerebellum, also present in
    the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the
    heart, skeletal muscle and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIN2C: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GRIN2C gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grin2c1 , 5 glutamate receptor, ionotropic, NMDA2C (epsilon 3)1, 5 85.59(n)1
    89.23(a)1
      11 (80.80 cM)5
    148131  NM_010350.21  NP_034480.21 
     1152491695 
    chicken
    (Gallus gallus)
    Aves GRIN2C1 glutamate receptor, ionotropic, N-methyl D-aspartate more 80.67(n)
    79.54(a)
      431090  XM_003642367.2  XP_003642415.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIN2C6
    glutamate receptor, ionotropic, N-methyl D-asparta...
    58(a)
    1 ↔ 1
    2(115432822-115546688)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grin2c1 glutamate receptor, ionotropic, N-methyl D-aspartate more 67.48(n)
    69.32(a)
      100496638  XM_004918478.1  XP_004918535.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003336481 glutamate receptor ionotropic, NMDA 2C-like 70.38(n)
    71.93(a)
      100333648  XM_002663984.2  XP_002664030.2 


    ENSEMBL Gene Tree for GRIN2C (if available)
    TreeFam Gene Tree for GRIN2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIN2C gene
    GRIN12  GRIN3A2  GRIN2B2  GRIN2D2  GRIN2A2  GRIN3B2  
    6 SIMAP similar genes for GRIN2C using alignment to 3 protein entries:     NMDE3_HUMAN (see all proteins):
    NMDAR2C    GRIN2B    GRIN2A    NR2A    GRIN2D    GRID2

    Find genes that share paralogs with GRIN2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIN2C (see all 520)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1843554461,2
    --72837682(+) GCCTCA/GTGTGT 1 -- int10--------
    rs1891483051,2
    C--72837706(+) AATGCA/GGCCAG 1 -- int10--------
    rs1419513541,2
    --72837794(+) AGGGCA/GTCCCT 1 -- int10--------
    rs1500973321,2
    --72837816(+) CAGGA-/CCCCC 
            
    CAGCC
    1 -- int10--------
    rs99012831,2
    C,F,A,H--72837832(+) CCCTGG/ACACAA 1 -- int125Minor allele frequency- A:0.45NS EA NA WA CSA 2536
    rs98932411,2
    C,F,H--72837930(+) AGGATG/AGGTGG 1 -- int15Minor allele frequency- A:0.01NS EA NA 536
    rs1170736491,2
    F--72838163(+) AGTGTG/ATTGTA 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1472868231,2
    C--72838189(+) GTCCCA/GGTGCT 1 -- ut310--------
    rs10471811,2
    F--72838282(+) AGCAGC/G/TCATGA 2 -- ut31 ese31MN 184
    rs1393727361,2
    --72838373(+) TGAGAA/CGAGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for GRIN2C (72838162 - 72857627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for GRIN2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518292CNV Loss19592680
    nsv833540CNV Loss17160897
    dgv3253n71CNV Loss21882294
    nsv908744CNV Loss21882294
    dgv3254n71CNV Loss21882294
    nsv519902CNV Loss19592680
    nsv908743CNV Loss21882294

    Human Gene Mutation Database (HGMD): GRIN2C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIN2C
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIN2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138254    OMIM disorders: --

    2 diseases for GRIN2C:    
    About MalaCards
    toxic encephalopathy    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for GRIN2C:
    Schizophrenia     Toxic encephalopathy

    Find genes that share disorders with GRIN2C           About GenesLikeMe

    Genetic Association Database (GAD): GRIN2C
    Human Genome Epidemiology (HuGE) Navigator: GRIN2C (6 documents)

    Export disorders for GRIN2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIN2C gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with GRIN2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery. (PubMed id 9037519)1, 2, 9 Lin Y.J.... Giordano T. (Brain Res. Mol. Brain Res. 1996)
    2. Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PubMed id 9480759)1, 3, 9 Kalsi G....Gurling H. (Genomics 1998)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    5. Neurotransmission and bipolar disorder: a systematic family-based association study. (PubMed id 18444252)1, 4 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    6. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. (PubMed id 12082569)1, 4 Williams N.M....O'Donovan M.C. (Mol. Psychiatry 2002)
    7. Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression. (PubMed id 15920498)1, 9 Karolewicz B....Ordway G.A. (Neuropsychopharmacology 2005)
    8. Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. (PubMed id 16606616)1, 9 Chen B.S....Roche K.W. (J. Biol. Chem. 2006)
    9. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in vasopressin and oxytocin neuroendocrine cells. (PubMed id 9073168)7, 9 Al-Ghoul W.M....Greenwood R.S. (Brain Res. Mol. Brain Res. 1997)
    10. The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression. (PubMed id 9798920)1, 9 Daggett L.P....VeliAselebi G. (J. Neurochem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2905 HGNC: 4587 AceView: GRIN2C Ensembl:ENSG00000161509 euGenes: HUgn2905
    ECgene: GRIN2C Kegg: 2905 H-InvDB: GRIN2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRIN2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRIN2C gene:
    Search GeneIP for patents involving GRIN2C

    Licensable Technologies for GRIN2C gene:
     Tufts University:  Treatment of Obsessive-Compulsive Disorder and Compulsive Disorders (including Over-Eating, Alcoholism & Smoking)
    GeneCards and IP:
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