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GRIN2B Gene

protein-coding   GIFtS: 68
GCID: GC12M013714

Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B


(Previous symbol: NMDAR2B)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B1 2     hNR32 3
NMDAR2B1 2 3 5     N-Methyl D-Aspartate Receptor Subtype 2B2 3
Glutamate [NMDA] Receptor Subunit Epsilon-22 3     N-Methyl-D-Aspartate Receptor Subunit 32 3
GluN2B2 3     MRD62 5
NR2B2 3     Glutamate Receptor Ionotropic, NMDA 2B2
NR32 3     Glutamate Receptor Subunit Epsilon-22

External Ids:    HGNC: 45861   Entrez Gene: 29042   Ensembl: ENSG000002730797   OMIM: 1382525   UniProtKB: Q132243   

Export aliases for GRIN2B gene to outside databases

Previous GC identifers: GC12M013455 GC12M013858 GC12M013614 GC12M013605


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIN2B Gene:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has
been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic
transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers
composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or
GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant
excitatory neurotransmitter receptor in the mammalian brain. (provided by RefSeq, Jul 2008)

GeneCards Summary for GRIN2B Gene:
GRIN2B (glutamate receptor, ionotropic, N-methyl D-aspartate 2B) is a protein-coding gene. Diseases associated with GRIN2B include mental retardation, autosomal dominant 6, and epileptic encephalopathy, early infantile, 1. GO annotations related to this gene include glycine binding and calcium channel activity. An important paralog of this gene is GRIN2C.

UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224
Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and
voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites,
acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA
receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal
death (By similarity)

summary for GRIN2B Gene:
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.

Gene Wiki entry for GRIN2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIN2B gene promoter:
         AP-1   AP-2alpha isoform 3   ATF-2   AP-2alpha isoform 2   CREB   deltaCREB   c-Jun   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIN2B promoter sequence
   Search Chromatin IP Primers for GRIN2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIN2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p12

GRIN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIN2B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M013714:  view genomic region     (about GC identifiers)

Start:
13,693,165 bp from pter      End:
14,133,053 bp from pter
Size:
439,889 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, NMDA 2B precursor  
Size: 1484 amino acids; 166367 Da
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1,
GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 and NETO1 (By similarity).
Interacts with MAGI3. Interacts with DAPK1 (By similarity)
3 PDB 3D structures from and Proteopedia for GRIN2B:
1S11 (3D)        1S2S (3D)        2IPV (3D)    
Secondary accessions: Q12919 Q13220 Q13225 Q14CU4 Q9UM56

Explore the universe of human proteins at neXtProt for GRIN2B: NX_Q13224

Explore proteomics data for GRIN2B at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity)1
  • Glycosylation2 at Asn74, Asn341, Asn348, Asn444, Asn491, Asn542, Asn688
  • Modification sites at PhosphoSitePlus

  • See GRIN2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000825.2  
    ENSEMBL proteins: 
     ENSP00000477455  
    Reactome Protein details: Q13224

    GRIN2B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GRIN2B

    GRIN2B Antibody Products:

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    Abcam antibodies for GRIN2B
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    ThermoFisher Antibody for GRIN2B
    LSBio Antibodies in human, mouse, rat for GRIN2B

    GRIN2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for GRIN2B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRIN2B
    Cloud-Clone Corp. CLIAs for GRIN2B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluN2B
    Ionotropic glutamate receptors

    Selected InterPro protein domains (see all 7):
     IPR018884 NMDAR2_C
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001638 SBP_bac_3
     IPR001320 Iontro_glu_rcpt

    Graphical View of Domain Structure for InterPro Entry Q13224

    ProtoNet protein and cluster: Q13224

    2 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature


    UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily


    GRIN2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMDE2_HUMAN, Q13224
    Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and
    voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites,
    acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA
    receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal
    death (By similarity)

         Genatlas biochemistry entry for GRIN2B:
    N-methyl D-aspartate receptor 2,epsilon 2 subunit glutamate receptor,expressed in hippocampal pyramidal
    cells,neocortex and basal ganglia,involved in excitatory neurotransmission,in neuronal cell death and in the
    epileptic hyperexcitability of dysplastic cortical regions,playing a central role in verbal memory and cognitive
    function

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0004972N-methyl-D-aspartate selective glutamate receptor activity IBA--
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005261cation channel activity ----
         
    GRIN2B for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for GRIN2B:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella-containin 

         6 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Grin2b):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  nervous system 
     no phenotypic analysis 

    GRIN2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for GRIN2B: Grin2btm1Mim Grin2btm2Mim Grin2btm1Rsp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIN2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIN2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIN2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIN2B

    miRNA
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    Block miRNA regulation of human, mouse, rat GRIN2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIN2B (see all 12):
    hsa-miR-642a hsa-miR-1224-3p hsa-miR-516b* hsa-miR-3653 hsa-miR-197 hsa-miR-211 hsa-miR-3154 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidGRIN2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRIN2B
    Predesigned siRNA for gene silencing in human, mouse, rat GRIN2B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: GRIN2B (NM_000834)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIN2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIN2B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMDE2_HUMAN, Q13224: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    extracellular2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8768735
    GO:0008021synaptic vesicle IEA--
    GO:0009986cell surface ISS--
    GO:0014069postsynaptic density IEA--

    GRIN2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIN2B About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Ras activation uopn Ca2+ infux through NMDA receptor0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    CREB phosphorylation through the activation of Ras0.78
    CREB phosphorylation through the activation of CaMKII0.00
    Long-term potentiation0.35
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    4Glutamic acid signaling
    Glutamic acid signaling
    Synaptic Neurotransmission: Glutamatergic Excitation0.00
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for GRIN2B
        Synaptic Neurotransmission: Glutamatergic Excitation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIN2B (see all 7)
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Pathogenesis of ALS
    Intracellular Calcium Signaling
    Huntington's Disease Pathway
    PEDF Induced Signaling

    1 Cell Signaling Technology (CST) Pathway for GRIN2B
        Neuroscience

    3 GeneGo (Thomson Reuters) Pathways for GRIN2B
        Signal transduction Erk Interactions- Inhibition of Erk
    Neurophysiological process PGE2-induced pain processing
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

    5 BioSystems Pathways for GRIN2B
        Hypothetical Network for Drug Addiction
    BDNF signaling pathway
    Alzheimers Disease
    ErbB4 signaling events
    Reelin signaling pathway

    3 Reactome Pathways for GRIN2B
        Ras activation uopn Ca2+ infux through NMDA receptor
    Unblocking of NMDA receptor, glutamate binding and activation
    CREB phosphorylation through the activation of CaMKII


    Selected Kegg Pathways  (Kegg details for GRIN2B) (see all 15):
        Ras signaling pathway
    Rap1 signaling pathway
    Neuroactive ligand-receptor interaction
    Circadian entrainment
    Long-term potentiation


    GRIN2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIN2B: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIN2B

    Selected Interacting proteins for GRIN2B (Q132241, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAMK2AQ9UQM71, 2, 3EBI-2256942,EBI-1383687 MINT-8296785 MINT-8296796 MINT-8296809 I2D: score=6 
    DLG4P783521, 2, 3EBI-2256942,EBI-80389 MINT-1899852 MINT-1900667 I2D: score=11 
    MAGI3Q5TCQ92, 3MINT-1796789 MINT-72931 I2D: score=3 
    ENSG00000137345Q166533I2D: score=1 
    ENSG00000230885Q166533I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001964startle response IEA--
    GO:0001967suckling behavior IEA--
    GO:0006810transport TAS8768735

    GRIN2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIN2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DL-AP5 Sodium saltSodium salt of DL-AP5 (Cat. No. 0105)[1303993-72-7]
    (+)-MK 801 maleate Non-competitive NMDA antagonist, acts at ion channel site [77086-22-7]
    D-AP5 Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) [79055-68-8]
    QNZ 46NR2C/NR2D-selective NMDA receptor non-competitive antagonist[1237744-13-6]
    DL-AP5 Potent, selective NMDA antagonist [76326-31-3]

    4 HMDB Compounds for GRIN2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    LoperamideApo-Loperamide (see all 10)53179-11-6--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 DrugBank Compounds for GRIN2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Haloperidol-- 52-86-8targetantagonist11752352 17588330 17092607 11102491 11741727 9572299 16407246
    Felbamate-- 25451-15-4targetantagonist18253065 10215667 11752352 18311896 10690753
    MemantineMemantina [INN-Spanish] (see all 5)19982-08-2targetantagonist16009352 14530799 11854433 9120573 15452358
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17662248 17229973
    Meperidine-- 57-42-1targetantagonist10735801
    Tenocyclidine-- 21500-98-1targetantagonist2538766

    Selected IUPHAR Ligands for GRIN2B (GluN2B) (see all 35)    About this table
    LigandTypeActionAffinityPubmed IDs
    phencyclidine
    Channel blockerNone--
    [3H]CGP39653
    NoneNone--
    LY233053
    AntagonistAntagonist--
    D-aspartate
    AgonistAgonist--
    L701324
    AntagonistAntagonist--
    glycine
    AgonistAgonist--
    Mg2+
    Channel blockerNone--
    MK-801
    Channel blockerNone--
    CGP37849
    AntagonistAntagonist--
    [3H]glycine
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for GRIN2B gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 89.8 215 14499953 (4), 10764765 (3), 11841566 (3), 15629759 (3) (see all 99)
    glutamate 72.2 33 15083261 (2), 14662797 (2), 9100675 (2), 19324536 (2) (see all 21)
    ifenprodil 69 4 15054078 (1), 15857299 (1), 16962290 (1), 16870468 (1)
    kainate 56.3 3 11334999 (1), 12535174 (1), 18462708 (1)
    tyrosine 37.8 43 11501177 (6), 11483655 (4), 9645956 (2), 19864302 (2) (see all 19)
    clozapine 31.3 7 11807413 (3), 12853100 (1)
    ethanol 26.4 16 14499953 (4), 15755907 (3), 12787828 (2), 19350219 (1) (see all 6)
    ketamine 24.6 6 19815434 (1), 11501177 (1)
    calcium 15.2 8 10764765 (2), 17908242 (1), 14706619 (1), 19756518 (1) (see all 5)
    serine 14.5 2 16266783 (1), 11823786 (1)



    GRIN2B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for GRIN2B gene: 
    NM_000834.3  

    Unigene Cluster for GRIN2B:

    Glutamate receptor, ionotropic, N-methyl D-aspartate 2B
    Hs.654430  [show with all ESTs]
    Unigene Representative Sequence: U88963
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000609686
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate GRIN2B (see all 12):
    hsa-miR-642a hsa-miR-1224-3p hsa-miR-516b* hsa-miR-3653 hsa-miR-197 hsa-miR-211 hsa-miR-3154 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidGRIN2B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB208850.1 BC113618.1 BC113620.1 U11287.1 U28758.1 U28861.1 U28862.1 U88963.1 
    U90278.1 

    2 DOTS entries:

    DT.404681  DT.91936890 

    14 AceView cDNA sequences:

    U90278 U11287 U28861 AA770476 U88963 BX280447 NM_000834 BE382323 
    U28758 U28862 BF763635 BF952993 AW627983 BE702462 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIN2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTTTTGC
    GRIN2B Expression
    About this image

    GRIN2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIN2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654430

    UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224
    Tissue specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower
    expression in the basal ganglia

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIN2B: 
              Neurotransmitter Receptors in human mouse rat
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              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GRIN2B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grin2b1 , 5 glutamate receptor, ionotropic, NMDA2B (epsilon 2)1, 5 91.48(n)1
    98.65(a)1
      6 (66.38 cM)5
    148121  NM_008171.31  NP_032197.31 
     1357132325 
    chicken
    (Gallus gallus)
    Aves GRIN2B1 glutamate receptor, ionotropic, N-methyl D-aspartate 2B less 86.1(n)
    94.07(a)
      417965  XM_416204.3  XP_416204.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIN2B6
    glutamate receptor, ionotropic, N-methyl D-asparta...
    90(a)
    1 ↔ 1
    GL343397.1(285973-506948)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grin2b1 glutamate receptor, ionotropic, N-methyl D-aspartate 2B less 75.32(n)
    86.04(a)
      100490580  XM_002932162.2  XP_002932208.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003348831 glutamate receptor ionotropic, NMDA 2B-like 70.32(n)
    74.83(a)
      100334883  XM_003198012.2  XP_003198060.2 


    ENSEMBL Gene Tree for GRIN2B (if available)
    TreeFam Gene Tree for GRIN2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIN2B gene
    GRIN2C2  GRIN12  GRIN3A2  GRIN2D2  GRIN2A2  GRIN3B2  
    5 SIMAP similar genes for GRIN2B using alignment to 1 protein entry:     NMDE2_HUMAN:
    GRIN2C    GRIN2D    NMDAR2C    GRIN2A    NR2A

    GRIN2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIN2B (see all 9033)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659004
    Mental retardation, autosomal dominant 6 (MRD6)4--see VAR_0659002 R C mis40--------
    VAR_0693844
    Mental retardation, autosomal dominant 6 (MRD6)4--see VAR_0693842 P L mis40--------
    rs1407448181,2
    C,Funtested113584840(+) CGACGC/ACCCCG 2 /A /S mis11Minor allele frequency- A:0.00NA 4490
    rs18052461,2
    C,F,Huntested113584862(+) TGCCTG/AAAGAA 2 /F syn115Minor allele frequency- A:0.03NA NS EA EU 6733
    rs18052471,2
    C,F,Huntested113584883(+) CTGCCA/GTGGAG 2 H syn129Minor allele frequency- G:0.19NA NS EA WA CSA EU 8439
    rs2014051571,2
    Cuntested113585432(+) CAGCTA/GCGGCA 2 R syn10--------
    rs1998431361,2
    Cuntested113586368(+) TTGGCC/TGTGCG 2 T syn10--------
    rs351255341,2
    C,Funtested113586389(+) AGGATG/ATTGGA 2 /N syn13Minor allele frequency- A:0.01NA CSA 4630
    rs18062011,2
    C,F,Huntested113586416(+) GTTGCG/AGTGGG 2 /T syn128Minor allele frequency- A:0.28EA NA NS WA EU 10339
    rs1505541841,2
    Cuntested113591718(+) TTCCAC/TCCAGA 2 G syn11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for GRIN2B (13693165 - 13943165 bp, first 250kb of GRIN2B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIN2B (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668471CNV Deletion23128226
    esv4674CNV Deletion18987735
    esv2745578CNV Deletion23290073
    esv2670197CNV Deletion23128226
    esv2745577CNV Deletion23290073
    esv2745575CNV Deletion23290073
    esv2745576CNV Deletion23290073
    esv1197500CNV Deletion17803354
    esv2745573CNV Deletion23290073
    esv2666327CNV Deletion23128226

    Human Gene Mutation Database (HGMD): GRIN2B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIN2B
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIN2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138252   
    OMIM disorders: 613970  
    UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224
  • Mental retardation, autosomal dominant 6 (MRD6) [MIM:613970]: A disorder characterized by significantly
    below average general intellectual functioning associated with impairments in adaptive behavior and manifested
    during the developmental period. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Note=A chromosomal aberrations involving GRIN2B has been found in patients with mental retardation.
    Translocations t(9;12)(p23;p13.1) and t(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1

  • Selected diseases for GRIN2B (see all 55):    
    About MalaCards
    mental retardation, autosomal dominant 6    epileptic encephalopathy, early infantile, 1    myoclonic astatic epilepsy    paine syndrome
    mental retardation, autosomal dominant 10    limbic encephalitis    fetal alcohol syndrome    chronic pain
    drug addiction    obsessive-compulsive disorder    nicotine addiction    dyslexia
    tardive dyskinesia    huntington's disease    bipolar i disorder    status epilepticus
    bipolar disorder    toxic encephalopathy    smallpox    attention deficit hyperactivity disorder

    5 diseases from the University of Copenhagen DISEASES database for GRIN2B:
    Schizophrenia     Toxic encephalopathy     Parkinson's disease     Huntington's disease
    Alzheimer's disease

    GRIN2B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for GRIN2B gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 51.3 33 17224684 (3), 11532724 (3), 11317224 (3), 16549338 (3) (see all 14)
    epilepsia partialis continua 50.9 1 14580662 (1)
    ischemic brain injury 49.9 2 15857299 (2)
    huntington disease 47.6 3 9100675 (2), 17569088 (1)
    dysplasia 31.6 2 16962290 (2)
    epilepsy 30.2 5 17506987 (2), 15030493 (1)
    alcoholism 28.9 5 15812607 (3), 16911840 (1)
    bipolar disorder 27.6 3 16549338 (2), 15952869 (1)
    alzheimers disease 21.6 4 18983893 (1), 11532724 (1), 18303265 (1)
    epilepsy temporal lobe 19.6 1 17472608 (1)

    Genetic Association Database (GAD): GRIN2B
    Human Genome Epidemiology (HuGE) Navigator: GRIN2B (60 documents)

    Export disorders for GRIN2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIN2B gene, integrated from 10 sources (see all 402):
    (articles sorted by number of sources associating them with GRIN2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease. (PubMed id 18303265)1, 4, 9 Seripa D....Pilotto A. (Dement Geriatr Cogn Disord 2008)
    2. Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: a HuGE review and meta-analysis. (PubMed id 17224684)1, 4, 9 Li D. and He L. (Genet. Med. 2007)
    3. An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. (PubMed id 15841096)1, 4, 9 Qin S....He L. (Eur. J. Hum. Genet. 2005)
    4. Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. (PubMed id 11317224)1, 4, 9 Ohtsuki T....Arinami T. (Mol. Psychiatry 2001)
    5. Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population. (PubMed id 18983893)1, 4, 9 Jiang H. and Jia J. (Neurosci. Lett. 2009)
    6. Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease. (PubMed id 11956967)1, 4, 9 Tsai S.J....Hong C.J. (J Neural Transm 2002)
    7. N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels. (PubMed id 16549338)1, 4, 9 Martucci L....Kennedy J.L. (Schizophr. Res. 2006)
    8. Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens. (PubMed id 15812607)1, 4, 9 Tadic A....Soyka M. (Eur Arch Psychiatry Clin Neurosci 2005)
    9. Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia. (PubMed id 11807413)1, 4, 9 Hong C.J....Tsai S.J. (Psychiatr. Genet. 2001)
    10. mRNA distribution in adult human brain of GRIN2B, a N-methyl-D- aspartate (NMDA) receptor subunit. (PubMed id 9547169)1, 2, 9 Schito A.M.... Mandich P. (Neurosci. Lett. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2904 HGNC: 4586 AceView: GRIN2B Ensembl:ENSG00000273079 euGenes: HUgn2904
    ECgene: GRIN2B Kegg: 2904 H-InvDB: GRIN2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRIN2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRIN2B gene:
    Search GeneIP for patents involving GRIN2B

    Licensable Technologies for GRIN2B gene:
     Tufts University:  Treatment of Obsessive-Compulsive Disorder and Compulsive Disorders (including Over-Eating, Alcoholism & Smoking)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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