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GRIN2B Gene

protein-coding GIFtS: 71

GC12M013605

glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NMDAR2B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC142178 ^²
MGC142180 ^²
NMDAR2B ^², ³, ⁵
NR2B ^², ³
NR3 ^³
hNR3 ^², ³

Descriptions
N-methyl D-aspartate receptor subtype 2B ^³
N-methyl-D-aspartate receptor subunit 2B ^²
N-methyl-D-aspartate receptor subunit 3 ^³
glutamate receptor subunit epsilon-2 ^²
glutamate receptor, ionotropic, N-methyl D-aspartate 2B ^²

External Ids
HGNC: 4586¹
Entrez Gene: 2904²
UniProtKB: Q13224³
Ensembl: ENSG00000150086⁷

Search outside databases for aliases for GRIN2B gene

Previous GC identifers: GC12M013455 GC12M013858 GC12M013614

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRIN2B:

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor

channel has been shown to be involved in long-term potentiation, an activity-dependent increase in

the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.

NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2

(GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the

agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter

receptor in the mammalian brain. [provided by RefSeq]

UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224

Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and

voltage-dependent sensitivity to magnesium. Mediated by glycine

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRIN2B gene

Entrez Gene cytogenetic band: 12p12 Ensembl cytogenetic band: 12p13.1 HGNC cytogenetic band: 12p12

GRIN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M013605: (about GC identifiers)

Start:	13,605,411 bp from pter
End:	14,024,319 bp from pter
Size:	418,909 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009714.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224 (See protein sequence)

Recommended Name: Glutamate [NMDA] receptor subunit epsilon-2 precursor

Size: 1484 amino acids; 166367 Da

Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B,

GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and

GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and

DLG4. Interacts with HIP1 (By similarity). Interacts with MAGI3

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse,

postsynaptic cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1S11 (3D)

1S2S (3D)

2IPV (3D)

Secondary accessions: Q12919 Q13220 Q13225 Q14CU4 Q9UM56

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000825.2

ENSEMBL proteins:

ENSP00000279593

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NMDAR2B, NMDAR2A + 2B )
	Human Recombinant Proteins from Abnova (GRIN2B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/11 Gene Ontology (GO) cellular component terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8768735
GO:0008021	synaptic vesicle	IEA	--
GO:0014069	postsynaptic density	IEA	--
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	IDA	10480938 17047094

About this table

Antibodies for GRIN2B:

	Invitrogen Antibodies for GRIN2B
	Millipore Mono- and Polyclonal Antibodies for the study of GRIN2B
	Sigma-Aldrich Antibodies for GRIN2B
	R&D Systems Antibodies for GRIN2B ("NMDA R, NR2B Subunit")
	Cell Signaling Technology (CST) Antibodies for GRIN2B (NMDAR2B)
	Antibodies from Abcam (NMDAR2B, NMDAR2A + 2B ), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for GRIN2B

Assays for GRIN2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13224

ProtoNet protein and cluster: Q13224

2 Blocks protein families:

IPB001320 Ionotropic glutamate receptor

IPB001508 NMDA receptor signature

UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIN2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIN2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000834

Applied Biosystems Silencer® siRNAs for GRIN2B

Sigma-Aldrich siRNA and siRNA Panels for GRIN2B

Sigma-Aldrich shRNA for GRIN2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000834
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000834
untagged cDNA clone in CMV expression vector: NM_000834

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000834

UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224

Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and

voltage-dependent sensitivity to magnesium. Mediated by glycine

Genatlas biochemistry entry for GRIN2B:

N-methyl D-aspartate receptor 2,epsilon 2 subunit glutamate receptor,expressed in hippocampal

pyramidal cells,neocortex and basal ganglia,involved in excitatory neurotransmission,in neuronal

cell death and in the epileptic hyperexcitability of dysplastic cortical regions,playing a central

role in verbal memory and cognitive function

4 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Grin2b):

behavior/neurological

lethality-postnatal

nervous system

no phenotypic analysis

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity	TAS	8768735
GO:0005234	extracellular-glutamate-gated ion channel activity	IEA	--
GO:0005262	calcium channel activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for GRIN2B (Your Favorite Gene powered by Ingenuity) (see all 8 )

Amyotrophic Lateral Sclerosis Signaling
Neuropathic Pain Signaling In Dorsal Horn Neurons
Calcium Signaling
Glutamate Receptor Signaling
Ephrin Receptor Signaling

GeneDecks GRIN2B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GRIN2B

5/80 Interacting proteins for GRIN2B (ENSP00000279593³ Q13224^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 80 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG4	P78352²	STRING (score=.999) MINT-1899852 MINT-1900667
PTPN12	Q05209¹	EBI-2256942, EBI-2266035
PTPRB	P23467¹	EBI-2256942, EBI-1265766
PTPRC	P08575¹	EBI-2256942, EBI-1341
PTPRG	P23470¹	EBI-2256942, EBI-2258115

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5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001662	behavioral fear response	IEA	--
GO:0001701	in utero embryonic development	IEA	--
GO:0001964	startle response	IEA	--
GO:0001967	suckling behavior	IEA	--
GO:0006812	cation transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRIN2B

Sigma-Aldrich Small Molecules for GRIN2B:

Antagonist Blocker Agonist Inhibitor

Compounds for GRIN2B available from Tocris Bioscience

Compound	Action	CAS number
D-AP5	More active form of DL-AP5 (Cat. No. 0105)	[79055-68-8]
Ro 04-5595 hydrochloride	Selective NR2B antagonist	[194089-07-1]
TCS 46b	Orally active, subtype-selective NR1A/NR2B antagonist	[302799-86-6]
SDZ 220-581	Competitive NMDA antagonist	[174575-17-8]
Ro 25-6981 maleate	Subtype-selective NR2B antagonist	[169274-78-6]

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6 Novoseek chemical compound relationships for GRIN2B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	38.61	41	11501177 (6), 11483655 (4), 9645956 (2), 11466426 (2) (see all 18)
ethanol	19.63	13	14499953 (4), 15755907 (3), 12787828 (2), 12736333 (1) (see all 5)
calcium	15.41	6	10764765 (2), 17908242 (1), 14706619 (1), 11501177 (1)
nitric oxide	0.00	3	19245288 (1), 18923069 (1)
lithium	0.00	4	11841566 (3)
phosphatidylinositol	0.00	1	17239488 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIN2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIN2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000834

Sigma-Aldrich siRNA and siRNA Panels for GRIN2B

Sigma-Aldrich shRNA for GRIN2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000834

REFSEQ mRNAs for GRIN2B gene:

NM_000834.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000834

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000834
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000834
                                 untagged cDNA clone in CMV expression vector: NM_000834

Additional cDNA sequence:

AB208850.1 BC113618.1 BC113620.1 U11287.1 U28758.1 U28861.1 U28862.1 U88963.1

U90278.1

2 DOTS entries:

DT.404681 DT.91936890

14 AceView cDNA sequences:

U90278 BE382323 U11287 BX280447 AA770476 U88963 NM_000834 U28861

U28862 U28758 BF763635 BF952993 AW627983 BE702462

highest scoring ESTs for GRIN2B:

U88963 U11287 U90278 AA770476 BE382323 BE702462 BF763635 BX280447 NM_000834 U28758

Unigene Cluster for GRIN2B:

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Hs.654430 [show with all ESTs]

Unigene Representative Sequence: U88963

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000279593

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GRIN2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRIN2B

¹ / ² / ³

5 probe-sets matching GRIN2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32489_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U88963	1.00	1.00	1.00	1
210411_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U90278	0.80	1.00	0.91	1
210412_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U11287	0.80	1.00	0.91	1
210411_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210412_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTCTTTTGC

SOURCE GeneReport for Unigene cluster: Hs.654430
Expression variation in blood from EXPOLDB for GRIN2B
UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224
Tissue specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal
cells, lower expression in the basal ganglia

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRIN2B gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRIN2B¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	94.03(n) 98.32(a)	494009 NM_001008719.1 NP_001008719.1
chimpanzee (Pan troglodytes)	GRIN2B¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	99.62(n) 99.87(a)	473373 XM_528744.2 XP_528744.2
cow (Bos taurus)	GRIN2B¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	90.78(n) 96.83(a)	537804 XM_617989.3 XP_617989.2
rat (Rattus norvegicus)	Grin2b¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	91.32(n) 98.58(a)	24410 NM_012574.1 NP_036706.1
mouse (Mus musculus)	Grin2b^{1, 5}	6 (64.50 cM)⁵	glutamate receptor, ionotropic, NMDA2B (epsilon 2)^{1, 5}	91.43(n)¹ 98.58(a)¹	14812¹ NM_008171.3¹ NP_032197.3¹ AJ459261⁵ AJ459262⁵ (see all 14)

About this table Species with no ortholog for GRIN2B

ENSEMBL Gene Tree for GRIN2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRIN2B gene

GRIN2C² GRIN2D² GRIN2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2392 NCBI SNPs in GRIN2B are shown (see all 2392 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1036)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1805476^1,2	A,C,F,H,O	13605630(+)	`TTAAAG/TGTCAA`	1	--	ut3¹ ese³		16		EA NA EU WA	1474
	rs1805477^1,2	C,F,H,O	13605996(+)	`CCTTGC/TTCTTG`	1	--	ut3¹		11		NA EU EA WA	978
	rs890^1,2	C,F,H,O	13606575(-)	`CAAACT/GGATCT`	1	--	ut3¹		21		MN NA EA EU WA	1956
	rs1805501^1,2	C,F,H	13605326(+)	`TCTCAA/GTTTTC`	1	--	ng5¹		4		EU EA WA	420
	rs3764030^1,2	C,F,H	14024599(-)	`CGGGGG/AACACG`	1	--	ng3¹		9		EA EU WA	2306
	rs12818068^1,2	C,F,H	13910424(+)	`GTCGAC/TTCCCT`	1	--	ut5¹ ese³		15		NA EU EA WA	1400
	rs7307302^1,2	C,F,H	13605363(+)	`TCTGCC/TGGTAC`	1	--	ng5¹		4		EU EA WA	420
	rs3026174^1,2	C,F,H	13605051(+)	`GGTCAC/TGAGTG`	1	--	ng5¹		8		EU EA WA	836
	rs1805502^1,2	C,F,H	13605448(+)	`GTTGCA/GGGAAG`	1	--	ut3¹ ese³		7		NA EU EA WA	556
--	rs1019385^1,2	A,C	14026110(-)	`TAGGgG/Tgtgtg`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for GRIN2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 138252

10/14 Novoseek disease relationships for GRIN2B gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
epilepsia partialis continua	52.84	1	14580662 (1)
ischemic brain injury	51.96	2	15857299 (2)
schizophrenia	48.10	28	17224684 (3), 11532724 (3), 11317224 (3), 16549338 (3) (see all 13)
huntington disease	46.62	3	9100675 (2), 17569088 (1)
dysplasia	33.81	2	16962290 (2)
epilepsy	32.62	5	17506987 (2), 15030493 (1)
alcoholism	31.12	5	15812607 (3), 16911840 (1)
bipolar disorder	24.96	3	16549338 (2), 15952869 (1)
epilepsy temporal lobe	22.02	1	17472608 (1)
alzheimers disease	17.86	4	18983893 (1), 11532724 (1), 18303265 (1)

About this table

Human Gene Mutation Database: GRIN2B
Genetic Association Database: GRIN2B
Human Genome Epidemiology Navigator: GRIN2B (33 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/270 PubMed articles for GRIN2B gene (see all 270 ):

An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. (PubMed id 15841096)^{1, 3, 6} Qin S....He L. (2005)
Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. (PubMed id 11317224)^{1, 3, 6} Ohtsuki T....Arinami T. (2001)
Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease. (PubMed id 11956967)^{1, 3, 6} Tsai S.J....Hong C.J. (2002)
Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens. (PubMed id 15812607)^{1, 3, 6} Tadic A....Soyka M. (2005)
Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia. (PubMed id 11807413)^{1, 3, 6} Hong C.J....Tsai S.J. (2001)
mRNA distribution in adult human brain of GRIN2B, a N-methyl-D- aspartate (NMDA) receptor subunit. (PubMed id 9547169)^{1, 3, 4} Schito A.M.... Mandich P. (1997)
Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. (PubMed id 7959773)^{1, 3, 4} Mandich P.... Ajmar F. (1994)
Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes. (PubMed id 16266783)^{1, 3, 6} Iwayama Y....Yoshikawa T. (2006)
Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese. (PubMed id 12824739)^{1, 3, 6} Chiu H.J....Chen J.Y. (2003)
Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease. (PubMed id 11844890)^{1, 3, 6} Tsai S.J....Hong C.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2904	HGNC: 4586	AceView: GRIN2B	Ensembl:ENSG00000150086	euGenes: HUgn2904
ECgene: GRIN2B	H-InvDB: GRIN2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for GRIN2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for GRIN2B gene:

Tufts University:

Treatment of Obsessive-Compulsive Disorder and Compulsive Disorders (including Over-Eating, Alcoholism & Smoking)

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GRIN2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRIN2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRIN2B		Antibodies for GRIN2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRIN2B		Small molecules for GRIN2B
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (GRIN2B)
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	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GRIN2B (NMDAR2B)

	Recombinant Proteins (NMDAR2B, NMDAR2A + 2B )
	Antibodies (NMDAR2B, NMDAR2A + 2B )

Search OriGene for GRIN2B

Tocris compounds for GRIN2B

	Drugs for GRIN2B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRIN2B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GRIN2B Gene at Home site.
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GRIN2B Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for GRIN2B

Summaries
for GRIN2B

Genomic Location
for GRIN2B

Proteins
for GRIN2B

Protein Domains/
Families
for GRIN2B

Gene Function
for GRIN2B

Pathways & Interactions
for GRIN2B

Drugs & Compounds
for GRIN2B

Transcripts
for GRIN2B

Expression
for GRIN2B

Orthologs
for GRIN2B

Paralogs
for GRIN2B

SNPs/Variants
for GRIN2B

Disorders & Mutations
for GRIN2B

Medical News
for GRIN2B

Publications
for GRIN2B

Search for GRIN2B

Genome Databases showing GRIN2B

Other Databases showing GRIN2B

Specialized Databases showing GRIN2B

Licensable Technologies
for GRIN2B

Services
for GRIN2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRIN2B Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor GRIN2B

Summariesfor GRIN2B

Genomic Locationfor GRIN2B

Proteinsfor GRIN2B

Protein Domains/Familiesfor GRIN2B

Gene Functionfor GRIN2B

Pathways & Interactionsfor GRIN2B

Drugs & Compoundsfor GRIN2B

Transcriptsfor GRIN2B

Expression for GRIN2B

Orthologsfor GRIN2B

Paralogsfor GRIN2B

SNPs/Variantsfor GRIN2B

Disorders & Mutationsfor GRIN2B

Medical Newsfor GRIN2B

Publicationsfor GRIN2B

Search for GRIN2B

Genome Databases showing GRIN2B

Other Databases showing GRIN2B

Specialized Databases showing GRIN2B

Licensable Technologiesfor GRIN2B

Servicesfor GRIN2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRIN2B

Summaries
for GRIN2B

Genomic Location
for GRIN2B

Proteins
for GRIN2B

Protein Domains/
Families
for GRIN2B

Gene Function
for GRIN2B

Pathways & Interactions
for GRIN2B

Drugs & Compounds
for GRIN2B

Transcripts
for GRIN2B

Expression
for GRIN2B

Orthologs
for GRIN2B

Paralogs
for GRIN2B

SNPs/Variants
for GRIN2B

Disorders & Mutations
for GRIN2B

Medical News
for GRIN2B

Publications
for GRIN2B

Licensable Technologies
for GRIN2B

Services
for GRIN2B