GRIN2B Gene
protein-coding GIFtS: 71
GCID: GC12M013614
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|
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
(Previous symbol: NMDAR2B)
| |
Aliases
for GRIN2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B1 2 | | HNR31 | | NMDAR2B1 2 3 5 | | N-Methyl D-Aspartate Receptor Subtype 2B2 3 | | GluN2B1 2 3 | | N-Methyl-D-Aspartate Receptor Subunit 32 3 | | Glutamate [NMDA] Receptor Subunit Epsilon-22 3 | | MRD62 | | NR2B2 3 | | Glutamate Receptor Ionotropic, NMDA 2B2 | | NR32 3 | | Glutamate Receptor Subunit Epsilon-22 |
Export aliases for GRIN2B gene to outside databasesPrevious GC identifers: GC12M013455 GC12M013858 GC12M013605 |
Summaries
for GRIN2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRIN2B:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has beenshown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptictransmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composedof three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitterreceptor in the mammalian brain. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependentsensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a centralmediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activityinducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity)
 summary
for GRIN2B: NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.
Gene Wiki entry for GRIN2B
|
Genomic Views
for GRIN2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRIN2B gene promoter:
AP-1 AP-2alpha isoform 3 ATF-2 AP-2alpha isoform 2 CREB deltaCREB c-Jun AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRIN2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIN2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p12 Ensembl cytogenetic band: 12p13.1 HGNC cytogenetic band: 12p12GRIN2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M013614: view genomic region
(about GC identifiers)
Start:
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13,714,144 bp from pter |
End:
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14,133,053 bp from pter |
Size:
|
418,910 bases |
Orientation:
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minus strand |
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Proteins
for GRIN2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224 (See
protein sequence)Recommended Name: Glutamate receptor ionotropic, NMDA 2B precursor Size: 1484 amino acids; 166367 Da
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) anda third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3Aand PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 and NETO1 (By similarity). Interactswith MAGI3. Interacts with DAPK1 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;Multi-pass membrane protein
3 PDB 3D structures from  and Proteopedia  for GRIN2B:1S11 (3D)
1S2S (3D)
2IPV (3D)
Secondary accessions: Q12919 Q13220 Q13225 Q14CU4 Q9UM56Explore the universe of human proteins at neXtProt for GRIN2B: NX_Q13224
Post-translational modifications:
Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13224
GRIN2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000825.2
ENSEMBL proteins: ENSP00000279593 Reactome Protein details: Q13224
Human Recombinant Protein Products for GRIN2B:
Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18): About this table
GRIN2B for ontologies About GeneDecksing
GRIN2B Antibody Products:
Assay Products for GRIN2B: |
Protein
Domains /
Families
for GRIN2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRIN2B for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13224ProtoNet protein and cluster: Q13224 2 Blocks protein families: IPB001320 Ionotropic glutamate receptor IPB001508 NMDA receptor signature
UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily |
Function
for GRIN2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NMDE2_HUMAN, Q13224Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependentsensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a centralmediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activityinducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) Genatlas biochemistry entry for GRIN2B:N-methyl D-aspartate receptor 2,epsilon 2 subunit glutamate receptor,expressed in hippocampal pyramidal cells,neocortexand basal ganglia,involved in excitatory neurotransmission,in neuronal cell death and in the epileptichyperexcitability of dysplastic cortical regions,playing a central role in verbal memory and cognitive function
Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004970 | ionotropic glutamate receptor activity |
-- | -- | | GO:0004972 | N-methyl-D-aspartate selective glutamate receptor activity |
IEA | -- | | GO:0005102 | receptor binding |
-- | -- | | GO:0005234 | extracellular-glutamate-gated ion channel activity |
IEA | -- | | GO:0005261 | cation channel activity |
-- | -- |
GRIN2B for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for GRIN2B:
6 MGI mutant phenotypes (inferred from 11 alleles ) (MGI details for Grin2b):
GRIN2B for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for GRIN2B: Grin2btm1Mim Grin2btm2Mim Grin2btm1Rsp
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: GRIN2B (NM_000834) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRIN2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIN2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN2B |
|
Pathways & Interactions
for GRIN2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | CREB phosphorylation through the activation of CaMKII | | | 2 | Post NMDA receptor activation events | | | 3 | Transmission across Chemical Synapses | | | 4 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 5 | Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for GRIN2B
1  R&D Systems Pathway for GRIN2B
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIN2B (see all 7)
1 
Cell Signaling Technology (CST) Pathway for GRIN2B
3  GeneGo (Thomson Reuters) Pathways for GRIN2B
4  BioSystems Pathways for GRIN2B
5/9 
Reactome Pathways for GRIN2B (see all 9)
5/7 
Kegg Pathways (Kegg details for GRIN2B) (see all 7):
GRIN2B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIN2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/252 Interacting proteins for GRIN2B (Q132242, 3 ENSP000002795934) via UniProtKB, MINT, STRING, and/or I2D (see all 252)About this table
Gene Ontology (GO): 5/60 biological process terms (GO ID links to tree view) (see all 60): About this table
GRIN2B for ontologies About GeneDecksing
|
Drugs & Compounds
for GRIN2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GRIN2B for compounds About GeneDecksing
Compounds for GRIN2B available from Tocris Bioscience About this table
4 HMDB Compounds for GRIN2B About this table
6 DrugBank Compounds for GRIN2B About this table
10/17 Novoseek chemical compound relationships for GRIN2B gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nmda |
89.8 |
215 |
14499953 (4), 10764765 (3), 11841566 (3), 15629759 (3) (see all 99) |
| glutamate |
72.2 |
33 |
15083261 (2), 14662797 (2), 9100675 (2), 19324536 (2) (see all 21) |
| ifenprodil |
69 |
4 |
15054078 (1), 15857299 (1), 16962290 (1), 16870468 (1) |
| kainate |
56.3 |
3 |
11334999 (1), 12535174 (1), 18462708 (1) |
| tyrosine |
37.8 |
43 |
11501177 (6), 11483655 (4), 9645956 (2), 19864302 (2) (see all 19) |
| clozapine |
31.3 |
7 |
11807413 (3), 12853100 (1) |
| ethanol |
26.4 |
16 |
14499953 (4), 15755907 (3), 12787828 (2), 19350219 (1) (see all 6) |
| ketamine |
24.6 |
6 |
19815434 (1), 11501177 (1) |
| calcium |
15.2 |
8 |
10764765 (2), 17908242 (1), 14706619 (1), 19756518 (1) (see all 5) |
| serine |
14.5 |
2 |
16266783 (1), 11823786 (1) |
Search CenterWatch for drugs/clinical trials and news about GRIN2B / NMDE2
|
Transcripts
for GRIN2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRIN2B gene: NM_000834.3 Unigene Cluster for GRIN2B: Glutamate receptor, ionotropic, N-methyl D-aspartate 2B Hs.654430 [show with all ESTs]Unigene Representative Sequence: U889631 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000279593(uc001rbt.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: GRIN2B (NM_000834) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRIN2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIN2B |
Additional cDNA sequence: AB208850.1 BC113618.1 BC113620.1 U11287.1 U28758.1 U28861.1 U28862.1 U88963.1 U90278.1 2 DOTS entries: DT.404681 DT.91936890 14 AceView cDNA sequences: U90278 NM_000834 BE382323 BX280447 U88963 AA770476 U28861 U11287 U28758 U28862 BF763635 BF952993 AW627983 BE702462
GeneLoc Exon Structure
|
Expression
for GRIN2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRIN2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTTTTGC
About this image
See GRIN2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRIN2B
SOURCE GeneReport for Unigene cluster: Hs.654430
UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224Tissue specificity: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lowerexpression in the basal ganglia
SABiosciences Expression via Pathway-Focused PCR Arrays including GRIN2B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRIN2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRIN2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRIN2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIN2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN2B |
Orthologs
for GRIN2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for GRIN2B gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for GRIN2B (if available)
TreeFam Gene Tree for GRIN2B (if available) |
Paralogs
for GRIN2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRIN2B gene
- GRIA32 GRIN2D2 GRIK12 GRIA22 GRIK22 GRIN12 GRIA12 GRIK32
- GRIK42 GRIN3A2 GRIN2A2 GRIK52 GRIN3B2 GRIA42 GRIN2C2 GRID12
- GRID22
5 SIMAP similar genes for GRIN2B using alignment to 1 protein entry: NMDE2_HUMAN:GRIN2C GRIN2D NMDAR2C GRIN2A NR2A
GRIN2B for paralogs About GeneDecksing
|
Genomic Variants
for GRIN2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRIN2B (13714144 - 13964144 bp, first 250kb of GRIN2B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for GRIN2B
3 Indels: 39881 41391 39880
Human Gene Mutation Database (HGMD): GRIN2B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRIN2B |
|
Disorders
/ Diseases
for GRIN2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRIN2B for disorders About GeneDecksing
OMIM gene information: 138252
OMIM disorders: --
UniProtKB/Swiss-Prot: NMDE2_HUMAN, Q13224
Defects in GRIN2B are the cause of mental retardation autosomal dominant type 6 (MRD6) [MIM:613970]. Mentalretardation is characterized by significantly below average general intellectual functioning associated withimpairments in adaptative behavior and manifested during the developmental period. Note=Chromosomal aberrationsinvolving GRIN2B have been found in patients with mental retardation. Translocations t(9;12)(p23;p13.1) andt(10;12)(q21.1;p13.1) with a common breakpoint in 12p13.1
20/53  diseases for GRIN2B (see all 53): About MalaCardsepilepsia partialis continua paine syndrome myoclonic astatic epilepsy obsessive-compulsive disorder
attention deficit hyperactivity disorder amyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis temporal lobe epilepsy
limbic encephalitis status epilepticus tardive dyskinesia major depressive disorder
lateral sclerosis fetal alcohol syndrome brain injury bipolar i disorder
toxic encephalopathy anorexia nervosa esophageal squamous cell carcinoma systemic lupus erythematosus
5 diseases from the University of Copenhagen DISEASES database for GRIN2B:Schizophrenia Toxic encephalopathy Parkinson's disease Huntington's disease
Alzheimer's disease 10/14 Novoseek disease relationships for GRIN2B gene (see all 14) About this table
Genetic Association Database (GAD): GRIN2B
Human Genome Epidemiology (HuGE) Navigator: GRIN2B (60 documents)
Export disorders for GRIN2B gene to outside databases
|
Publications
for GRIN2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRIN2B gene, integrated from 9 sources (see all 386):
(articles sorted by number of sources associating them with GRIN2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. (PubMed id 15841096)1, 4, 9 Qin S....He L. (2005)
- Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. (PubMed id 11317224)1, 4, 9 Ohtsuki T....Arinami T. (2001)
- Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease. (PubMed id 11956967)1, 4, 9 Tsai S.J....Hong C.J. (2002)
- Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens. (PubMed id 15812607)1, 4, 9 Tadic A....Soyka M. (2005)
- Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia. (PubMed id 11807413)1, 4, 9 Hong C.J....Tsai S.J. (2001)
- mRNA distribution in adult human brain of GRIN2B, a N-methyl-D- aspartate (NMDA) receptor subunit. (PubMed id 9547169)1, 2, 9 Schito A.M.... Mandich P. (1997)
- Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. (PubMed id 7959773)1, 2, 9 Mandich P.... Ajmar F. (1994)
- Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes. (PubMed id 16266783)1, 4, 9 Iwayama Y....Yoshikawa T. (2006)
- Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese. (PubMed id 12824739)1, 4, 9 Chiu H.J....Chen J.Y. (2003)
- Association analysis for the genetic variants of the NMDA receptor subunit 2b and Alzheimer's disease. (PubMed id 11844890)1, 4, 9 Tsai S.J....Hong C.J. (2002)
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External Searches for GRIN2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing GRIN2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing GRIN2B gene
(According to HUGE)
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Specialized Databases showing GRIN2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for GRIN2B | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for GRIN2B gene:
Search GeneIP for patents involving GRIN2B
Licensable Technologies for GRIN2B gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for GRIN2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for GRIN2B | | OriGene shRNA RFP for GRIN2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRIN2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRIN2B | | | OriGene Protein Over-expression Lysate for GRIN2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GRIN2B | | OriGene 3'-UTR Clone for GRIN2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GRIN2B | | OriGene Custom Protein Services for GRIN2B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRIN2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRIN2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIN2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIN2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIN2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRIN2B |
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| | Antibodies & Assays for GRIN2B (NMDAR2B) |
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 | | | GRIN2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN2B |
|  |  |  |  | | | | ThermoFisher Antibody for GRIN2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIN2B |
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