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GRIN2A Gene

protein-coding GIFtS: 72

GC16M009762

glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NMDAR2A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NMDAR2A ^², ³, ⁵
NR2A ^², ³
OTTHUMP00000160135 ^²
OTTHUMP00000174531 ^²
hNR2A ^³

Descriptions
N-methyl D-aspartate receptor subtype 2A ^³
N-methyl-D-aspartate receptor channel, subunit epsilon-1 ^²
N-methyl-D-aspartate receptor subunit 2A ^²
NMDA receptor subtype 2A ^²
glutamate receptor, ionotropic, N-methyl D-aspartate 2A ^²

External Ids
HGNC: 4585¹
Entrez Gene: 2903²
UniProtKB: Q12879³
Ensembl: ENSG00000183454⁷

Search outside databases for aliases for GRIN2A gene

Previous GC identifers: GC16M009658 GC16M009991 GC16M009822

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRIN2A:

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These

receptors have been shown to be involved in long-term potentiation, an activity-dependent increase

in the efficiency of synaptic transmission thought to underlie certain kinds of memory and

learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1

(GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C

(GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: NMDE1_HUMAN, Q12879

Function: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability

and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both

types of subunits

Gene Wiki entry for GRIN2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRIN2A gene

Entrez Gene cytogenetic band: 16p13.2 Ensembl cytogenetic band: 16p13.2 HGNC cytogenetic band: 16p13.2

GRIN2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M009762: (about GC identifiers)

Start:	9,754,762 bp from pter
End:	10,184,112 bp from pter
Size:	429,351 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NMDE1_HUMAN, Q12879 (See protein sequence)

Recommended Name: Glutamate [NMDA] receptor subunit epsilon-1 precursor

Size: 1464 amino acids; 165283 Da

Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B,

GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and

GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1,

INADL and DLG4. Interacts with HIP1 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse,

postsynaptic cell membrane; Multi-pass membrane protein

Secondary accessions: O00669

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000824.1 NP_001127879.1 NP_001127880.1

ENSEMBL proteins:

ENSP00000385872 ENSP00000379818 ENSP00000332549 ENSP00000379820

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NMDAR2A, NMDAR2A + 2B )
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/11 Gene Ontology (GO) cellular component terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8768735
GO:0014069	postsynaptic density	IEA	--
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	IDA	10480938

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Antibodies for GRIN2A:

	Invitrogen Antibodies for GRIN2A
	Millipore Mono- and Polyclonal Antibodies for the study of GRIN2A
	Sigma-Aldrich Antibody Arrays and Antibodies for GRIN2A
	R&D Systems Antibodies for GRIN2A ("NMDA R, NR2A Subunit")
	Cell Signaling Technology (CST) Antibodies for GRIN2A (NMDAR2A)
	Antibodies from Abcam (NMDAR2A, NMDAR2A + 2B ), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for GRIN2A

Assays for GRIN2A:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of GRIN2A
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q12879

ProtoNet protein and cluster: Q12879

2 Blocks protein families:

IPB001320 Ionotropic glutamate receptor

IPB001508 NMDA receptor signature

UniProtKB/Swiss-Prot: NMDE1_HUMAN, Q12879

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIN2A)
		Millipore RNAi Products for the Analysis of GRIN2A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (GRIN2A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000833

Applied Biosystems Silencer® siRNAs for GRIN2A

Sigma-Aldrich siRNA and siRNA Panels for GRIN2A

Sigma-Aldrich shRNA for GRIN2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GRIN2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000833
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000833
untagged cDNA clones in CMV expression vector (see all 3): NM_000833

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000833

UniProtKB/Swiss-Prot: NMDE1_HUMAN, Q12879

Function: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability

and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both

types of subunits

Genatlas biochemistry entry for GRIN2A:

N-methyl D-aspartate receptor 2,epsilon 1 subunit glutamate receptor,expressed in hippocampal

pyramidal cells and basal ganglia,involved in excitatory neurotransmission,in neuronal cell death

and in the epileptic hyperexcitability of dysplastic cortical regions,playing a central role in

verbal memory and cognitive function

2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Grin2a):

behavior/neurological

nervous system

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity	TAS	8768735
GO:0005234	extracellular-glutamate-gated ion channel activity	IEA	--
GO:0005262	calcium channel activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GRIN2A (Your Favorite Gene powered by Ingenuity) (see all 7 )

Amyotrophic Lateral Sclerosis Signaling
Synaptic Long Term Potentiation
Neuropathic Pain Signaling In Dorsal Horn Neurons
Glutamate Receptor Signaling
Circadian Rhythm Signaling

GeneDecks GRIN2A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GRIN2A

5/71 Interacting proteins for GRIN2A (ENSP00000332549³ Q12879²) via UniProtKB, MINT, and/or STRING (see all 71 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG4	P78352²	STRING (score=.999) MINT-1900076 MINT-1900851 MINT-1901389
FYN	ENSP00000357656³	STRING (score=.999)
GRIN1	ENSP00000360616³	STRING (score=.999)
SRC	ENSP00000362659³	STRING (score=.998)
PTK2B	ENSP00000332816³	STRING (score=.993)

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5/21 Gene Ontology (GO) biological process terms (links to tree view) (see all 21 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001964	startle response	IEA	--
GO:0001975	response to amphetamine	IEA	--
GO:0006811	ion transport	IEA	--
GO:0006816	calcium ion transport	IEA	--
GO:0007215	glutamate signaling pathway	TAS	8768735

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRIN2A

Sigma-Aldrich Small Molecules for GRIN2A:

Antagonist Blocker Agonist Inhibitor

Compounds for GRIN2A available from Tocris Bioscience

Compound	Action	CAS number
(+)-MK 801 maleate	Non-competitive NMDA antagonist, acts at ion channel site	[77086-22-7]
NMDA	Selective NMDA agonist	[6384-92-5]
SDZ 220-581	Competitive NMDA antagonist	[174575-17-8]
PPPA	Competitive NR2A antagonist
(R)-CPP	More active enantiomer of (RS)-CPP (Cat. No. 0173)	[126453-07-4]

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8 Novoseek chemical compound relationships for GRIN2A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	25.31	17	18678878 (2), 11466426 (2), 12451687 (2), 15837820 (1) (see all 7)
calcium	23.23	6	8967993 (1), 15210575 (1), 8032174 (1), 11677266 (1) (see all 6)
guanylate	19.78	3	12859686 (1), 15590920 (1)
ethanol	14.59	8	11461975 (3), 14615013 (2), 8804725 (1)
methionine	5.87	2	9849671 (1)
lead	0.00	1	15973774 (1)
nadph	0.00	1	14720220 (1)
zinc	0.00	12	14615013 (3), 16166158 (3), 10402203 (2), 11528420 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIN2A)
		Millipore RNAi Products for the Analysis of GRIN2A Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (GRIN2A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_000833

Sigma-Aldrich siRNA and siRNA Panels for GRIN2A

Sigma-Aldrich shRNA for GRIN2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000833 NM_001134407 NM_001134408

REFSEQ mRNAs for GRIN2A gene (3 alternative transcripts):

NM_000833.3 NM_001134407.1 NM_001134408.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000833 NM_001134407 NM_001134408

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000833
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000833
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000833

Additional cDNA sequence:

AB209695.1 AK295620.1 AK308862.1 BC117131.1 BC143273.1 CR749843.1 U09002.1 U90277.1

6 DOTS entries:

DT.212872 DT.313196 DT.91752896 DT.120724194 DT.40125995 DT.95296161

24/70 AceView cDNA sequences (see all 70 ):

BM827634 H09825 CD674685 AA662774 BX117526 U90277 F08339 AA351127

Z41346 BX642521 AI124875 F09451 BX108347 F12999 F10594 Z38493

N48896 AL706699 AA782003 AL706855 AL709862 AK124698 AW961861 R43097

highest scoring ESTs for GRIN2A:

U09002 U90277 AA774828 AB209695 AL706855 BF946376 BF946382 BG150751 BM827634 BX642521

Unigene Cluster for GRIN2A:

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Hs.411472 [show with all ESTs]

Unigene Representative Sequence: NM_001134407

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000404927 ENST00000396573 ENST00000330684 ENST00000396575

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GRIN2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRIN2A

¹ / ² / ³

9 probe-sets matching GRIN2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
46626_at²^{, 3}	U95-B	1	1.00	1.00	0.95	0.88	T65537	0.20	1.00	0.72	1
38236_at²^{, 3}	U95-A	1	1.00	1.00	0.36	1.10	U09002	1.00	1.00	1.00	1
54354_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.09	AA662774	0.20	1.00	0.72	1
231384_at²^{, 3}	U133-B	1	1.00	1.00	--	--	T65537	0.20	1.00	0.72	1
206534_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000833	0.60	1.00	0.82	1
242286_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N48896	0.20	1.00	0.72	1
231384_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206534_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242286_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRIN2A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AGGAAGTGCT

SOURCE GeneReport for Unigene cluster: Hs.411472
Expression variation in blood from EXPOLDB for GRIN2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GRIN2A gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRIN2A¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	90.03(n) 94.81(a)	490012 XM_547132.2 XP_547132.2
chimpanzee (Pan troglodytes)	GRIN2A¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	99.5(n) 99.52(a)	454396 NM_001034189.1 NP_001029361.1
rat (Rattus norvegicus)	Grin2a¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	89.16(n) 95.22(a)	24409 NM_012573.2 NP_036705.2
mouse (Mus musculus)	Grin2a^{1, 5}	16 (3.40 cM)⁵	glutamate receptor, ionotropic, NMDA2A (epsilon 1)^{1, 5}	88.84(n)¹ 95.29(a)¹	14811¹ NM_008170.2¹ NP_032196.2¹ BC146289⁵ BC148800⁵ (see all 6)
chicken (Gallus gallus)	GRIN2A¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	75.57(n) 81.66(a)	427678 XM_425252.2 XP_425252.2

About this table Species with no ortholog for GRIN2A

ENSEMBL Gene Tree for GRIN2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GRIN2A gene

GRIN2C² GRIN2D² GRIN2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2948 NCBI SNPs in GRIN2A are shown (see all 2948 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1262)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1420040^1,2	A,C,F,H,O	9757898(+)	`TTTGAA/GAATAT`	2	--	ut3¹		16	EU EA WA NA	1470
	rs1014531^1,2	A,C,F,H,O	9763295(+)	`TCAGGG/ATAGAT`	2	--	ut3¹		15	NA EA MN EU WA	1412
	rs3785185^1,2	A,C,F,H	10185035(-)	`GGCTCC/TCTGAG`	1	--	ng3¹		4	EU EA WA	412
	rs8045712^1,2	A,C,F,H	9758623(+)	`GTCTCC/TTAAGT`	2	--	ut3¹		12	EU EA WA	1258
	rs4780876^1,2	A,C,F,H	10185720(+)	`taaaaC/Tatcac`	1	--	ng3¹		8	EU EA WA	838
	rs9940680^1,2	A,C,F,H	9758358(+)	`CTGGTG/CTATCA`	2	--	ut3¹		7	NA EU EA WA	558
	rs9933624^1,2	A,C,F,H	9758379(+)	`TCAAAT/CGTCAA`	2	--	ut3¹		4	EU EA WA	418
	rs1070498^1,2	A,C,F,H	10185924(+)	`TTCCAG/AGAATG`	1	--	ng3¹		8	EU EA WA	838
	rs1070499^1,2	A,C,F,H	10185961(+)	`GGAGAA/GGGGCA`	1	--	ng3¹ trp³		4	EU EA WA	412
	rs17791953^1,2	C,F,H	9757601(+)	`ATTTAA/CGATTA`	2	--	ut3¹		12	NA EU EA WA	1074

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HapMap Linkage Disequilibrium images for GRIN2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 138253

8 Novoseek disease relationships for GRIN2A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	43.65	21	17011703 (4), 18585682 (3), 12724619 (3), 15774266 (3) (see all 9)
attention-deficit hyperactivity disorder	31.27	1	14699423 (1)
huntington disease	29.59	5	17569088 (2), 15742215 (1)
bipolar disorder	27.90	4	18585682 (2), 15952869 (1), 12809987 (1)
alcoholism	7.22	4	18606955 (4)
dysplasia	1.50	1	16957582 (1)
mood disorders	0.00	1	12809987 (1)
epilepsy	0.00	1	17234586 (1)

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Human Gene Mutation Database: GRIN2A
Genetic Association Database: GRIN2A
Human Genome Epidemiology Navigator: GRIN2A (14 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/235 PubMed articles for GRIN2A gene (see all 235 ):

A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia. (PubMed id 12724619)^{1, 3, 6} Itokawa M.... Yoshikawa T. (2003)
Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia. (PubMed id 15774266)^{1, 3, 6} Iwayama-Shigeno Y....Yoshikawa T. (2005)
Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes. (PubMed id 16266783)^{1, 3, 6} Iwayama Y....Yoshikawa T. (2006)
NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. (PubMed id 15742215)^{1, 3, 6} Arning L....Epplen J.T. (2005)
Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein. (PubMed id 8061049)^{1, 3, 4} Foldes R.L.... Kamboj R.K. (1994)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. (PubMed id 12082569)^{3, 6} Williams N.M....O'Donovan M.C. (2002)
Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. (PubMed id 9480759)^{2, 3} Kalsi G....Gurling H. (1998)
Cloning and functional characterization of human heteromeric N- methyl-D-aspartate receptors. (PubMed id 8768735)^{3, 4} Hess S.D.... Velicelebi G. (1996)
The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth. (PubMed id 17922030)^{1, 3} Kim M.S....Sidransky D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2903	HGNC: 4585	AceView: GRIN2A	Ensembl:ENSG00000183454	euGenes: HUgn2903
ECgene: GRIN2A	H-InvDB: GRIN2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for GRIN2A
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for GRIN2A gene:

Tufts University:

Treatment of Obsessive-Compulsive Disorder and Compulsive Disorders (including Over-Eating, Alcoholism & Smoking)

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GRIN2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRIN2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRIN2A		Antibodies for GRIN2A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRIN2A		Small molecules for GRIN2A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (GRIN2A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for GRIN2A (NMDAR2A)

	Recombinant Proteins (NMDAR2A, NMDAR2A + 2B )
	Antibodies (NMDAR2A, NMDAR2A + 2B )

Search OriGene for GRIN2A

Tocris compounds for GRIN2A

	Drugs for GRIN2A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GRIN2A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
GRIN2A Gene at Home site.
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GRIN2A Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for GRIN2A

Summaries
for GRIN2A

Genomic Location
for GRIN2A

Proteins
for GRIN2A

Protein Domains/
Families
for GRIN2A

Gene Function
for GRIN2A

Pathways & Interactions
for GRIN2A

Drugs & Compounds
for GRIN2A

Transcripts
for GRIN2A

Expression
for GRIN2A

Orthologs
for GRIN2A

Paralogs
for GRIN2A

SNPs/Variants
for GRIN2A

Disorders & Mutations
for GRIN2A

Medical News
for GRIN2A

Publications
for GRIN2A

Search for GRIN2A

Genome Databases showing GRIN2A

Other Databases showing GRIN2A

Specialized Databases showing GRIN2A

Licensable Technologies
for GRIN2A

Services
for GRIN2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRIN2A Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor GRIN2A

Summariesfor GRIN2A

Genomic Locationfor GRIN2A

Proteinsfor GRIN2A

Protein Domains/Familiesfor GRIN2A

Gene Functionfor GRIN2A

Pathways & Interactionsfor GRIN2A

Drugs & Compoundsfor GRIN2A

Transcriptsfor GRIN2A

Expression for GRIN2A

Orthologsfor GRIN2A

Paralogsfor GRIN2A

SNPs/Variantsfor GRIN2A

Disorders & Mutationsfor GRIN2A

Medical Newsfor GRIN2A

Publicationsfor GRIN2A

Search for GRIN2A

Genome Databases showing GRIN2A

Other Databases showing GRIN2A

Specialized Databases showing GRIN2A

Licensable Technologiesfor GRIN2A

Servicesfor GRIN2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRIN2A

Summaries
for GRIN2A

Genomic Location
for GRIN2A

Proteins
for GRIN2A

Protein Domains/
Families
for GRIN2A

Gene Function
for GRIN2A

Pathways & Interactions
for GRIN2A

Drugs & Compounds
for GRIN2A

Transcripts
for GRIN2A

Expression
for GRIN2A

Orthologs
for GRIN2A

Paralogs
for GRIN2A

SNPs/Variants
for GRIN2A

Disorders & Mutations
for GRIN2A

Medical News
for GRIN2A

Publications
for GRIN2A

Licensable Technologies
for GRIN2A

Services
for GRIN2A