GRIN1 Gene
protein-coding GIFtS: 71
GCID: GC09P140032
|
|
glutamate receptor, ionotropic, N-methyl D-aspartate 1(Previous name: N-methyl-D-aspartate receptor subunit NR1 )
(Previous symbol: NMDAR1)
| |
Aliases
for GRIN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 11 2 | | MRD82 | | NMDAR11 2 3 5 | | NMDA12 | | GluN11 2 3 | | NR12 | | N-Methyl-D-Aspartate Receptor Subunit NR11 2 3 | | Glutamate [NMDA] Receptor Subunit Zeta 12 | | Glutamate [NMDA] Receptor Subunit Zeta-12 3 | | Glutamate Receptor Ionotropic, NMDA 12 | | NMD-R12 3 | | N-Methyl-D-Aspartate Receptor Channel, Subunit Zeta-12 |
Export aliases for GRIN1 gene to outside databasesPrevious GC identifers: GC09U990032 GC09P131724 GC09P133473 GC09P135390 GC09P137308 GC09P139152 GC09P109493 |
Summaries
for GRIN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for GRIN1:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamatereceptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form aligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underliememory and learning. Cell-specific factors are thought to control expression of different isoforms, possiblycontributing to the functional diversity of the subunits. Alternatively spliced transcript variants have beendescribed. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependentsensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis,excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Isinvolved in the cell surface targeting of NMDA receptors (By similarity)
 summary
for GRIN1: NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and
AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B)
subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane
potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA
receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the
postsynaptic region where it activates several signaling cascades, including pathways leading to the
induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in
excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions
including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and
neuropathic pain syndromes.
Gene Wiki entry for GRIN1
|
Genomic Views
for GRIN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the GRIN1 gene promoter:
AhR Spz1 Lmo2 Tal-1beta GATA-2 E47 PPAR-alpha Zic1 Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for GRIN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3GRIN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P140032: view genomic region
(about GC identifiers)
Start:
|
140,032,842 bp from pter |
End:
|
140,063,214 bp from pter |
Size:
|
30,373 bases |
Orientation:
|
plus strand |
|
Proteins
for GRIN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586 (See
protein sequence)Recommended Name: Glutamate receptor ionotropic, NMDA 1 precursor Size: 938 amino acids; 105373 Da
Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) anda third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B andPPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts withMYZAP
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynapticcell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (Bysimilarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity)
2 PDB 3D structures from  and Proteopedia  for GRIN1:2NR1 (3D)
3BYA (3D)
Secondary accessions: A6NLK7 A6NLR1 C9K0X1 P35437 Q12867 Q12868 Q5VSF3 Q5VSF4 Q5VSF5 Q5VSF6 Q5VSF7Q5VSF8 Q9UPF8 Q9UPF9Alternative splicing: 7 isoforms: Q05586-1 Q05586-2 Q05586-3 Q05586-4 Q05586-5 Q05586-6 Q05586-7 Explore the universe of human proteins at neXtProt for GRIN1: NX_Q05586
Post-translational modifications:
NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of theNMDAR-PPP2CB complex and the NMDAR channel activity (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q05586
GRIN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_000823.4 NP_001172019.1 NP_001172020.1 NP_015566.1 NP_067544.1
ENSEMBL proteins: ENSP00000360616 ENSP00000316915 ENSP00000360605 ENSP00000360601 ENSP00000360610 ENSP00000360608 ENSP00000360614 ENSP00000360615 ENSP00000316696 Reactome Protein details: Q05586
Human Recombinant Protein Products:
Gene Ontology (GO): 5/20 cellular component terms (GO ID links to tree view) (see all 20): About this table
GRIN1 for ontologies About GeneDecksing
GRIN1 Antibody Products:
Assay Products for GRIN1: |
Protein
Domains /
Families
for GRIN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
GRIN1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q05586ProtoNet protein and cluster: Q05586 3 Blocks protein families: IPB001320 Ionotropic glutamate receptor IPB001508 NMDA receptor signature IPB001828 Extracellular ligand-binding receptor
UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily |
Function
for GRIN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependentsensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis,excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Isinvolved in the cell surface targeting of NMDA receptors (By similarity) Genatlas biochemistry entry for GRIN1:N-methyl D-aspartate receptor 1,zeta 1subunit glutamate receptor,ubiquitously expressed in all CNS neurons,hippocampalpyramidal cells and neocortex,basal ganglia,mesencephalic dopaminergic neurons,throughout development and in adultbrain,playing a central role in verbal memory and cognitive function
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 5): GRIN1 (NM_007327) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRIN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN1 |
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004970 | ionotropic glutamate receptor activity |
-- | -- | | GO:0004972 | contributes to N-methyl-D-aspartate selective glutamate receptor activity |
IDA | 7679115 | | GO:0005102 | receptor binding |
-- | -- | | GO:0005234 | extracellular-glutamate-gated ion channel activity |
IEA | -- | | GO:0005261 | cation channel activity |
-- | -- |
GRIN1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for GRIN1: Grin1tm1Nak Grin1tm2.1Stl Grin1tm1.1Rpa Grin1tm1Cur Grin1tm1Stl Grin1tm2Slab
13 MGI mutant phenotypes (inferred from 24 alleles ) (MGI details for Grin1):
GRIN1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for GRIN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | CREB phosphorylation through the activation of CaMKII | | | 2 | Post NMDA receptor activation events | | | 3 | Transmission across Chemical Synapses | | | 4 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 5 | Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for GRIN1
1  R&D Systems Pathway for GRIN1
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for GRIN1 (see all 8)
1 
Cell Signaling Technology (CST) Pathway for GRIN1
3  GeneGo (Thomson Reuters) Pathways for GRIN1
3  BioSystems Pathways for GRIN1
5/9 
Reactome Pathways for GRIN1 (see all 9)
5/7 
Kegg Pathways (Kegg details for GRIN1) (see all 7):
GRIN1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/194 Interacting proteins for GRIN1 (Q055862, 3 ENSP000003606164) via UniProtKB, MINT, STRING, and/or I2D (see all 194)About this table
Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46): About this table
GRIN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for GRIN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
GRIN1 for compounds About GeneDecksing
Compounds for GRIN1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| (+)-MK 801 maleate | Non-competitive NMDA antagonist, acts at ion channel site | [77086-22-7] | | D-AP5 | Potent, selective NMDA antagonist. More active form of DL-AP5 (Cat. No. 0105) | [79055-68-8] | | NMDA | Selective NMDA agonist | [6384-92-5] | | SDZ 220-581 | Competitive NMDA antagonist | [174575-17-8] | | L-701,324 | NMDA antagonist, acts glycine site | [142326-59-8] |
3 HMDB Compounds for GRIN1 About this table
6 DrugBank Compounds for GRIN1 About this table
10/36 Novoseek chemical compound relationships for GRIN1 gene (see all 36) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nmda |
92.1 |
427 |
10217274 (5), 16573586 (4), 12777268 (4), 9038213 (3) (see all 99) |
| glutamate |
80.9 |
93 |
19422642 (10), 7666058 (3), 9832144 (3), 11793164 (2) (see all 59) |
| kainate |
64.9 |
14 |
10235640 (2), 18462708 (2), 9348349 (1), 9674563 (1) (see all 11) |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid |
60.5 |
2 |
9674563 (1), 12654500 (1) |
| phencyclidine |
48.2 |
1 |
11109007 (1) |
| gaba |
41.2 |
12 |
19602553 (3), 9674563 (1), 8982809 (1), 9618545 (1) (see all 5) |
| ethanol |
26.6 |
42 |
12824058 (4), 16573586 (4), 12853299 (4), 16179537 (4) (see all 13) |
| calcium |
25.9 |
18 |
10217274 (4), 9674563 (1), 10619662 (1), 18796005 (1) (see all 10) |
| magnesium |
18.8 |
4 |
9490808 (3), 16372011 (1) |
| dopamine |
18.4 |
7 |
15952869 (1), 16272960 (1), 14969737 (1), 15190099 (1) |
Search CenterWatch for drugs/clinical trials and news about GRIN1 / NMDZ1
|
Transcripts
for GRIN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for GRIN1 gene (5 alternative transcripts): NM_000832.6 NM_001185090.1 NM_001185091.1 NM_007327.3 NM_021569.3 Unigene Cluster for GRIN1: Glutamate receptor, ionotropic, N-methyl D-aspartate 1 Hs.558334 [show with all ESTs]Unigene Representative Sequence: L1326614 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371561(uc004clk.3 uc004cll.3) ENST00000471122(uc004cli.1 uc004clj.1)
ENST00000350902 ENST00000371550 ENST00000371546 ENST00000371555 ENST00000371553
ENST00000371559 ENST00000371560 ENST00000485413 ENST00000460273 ENST00000473811
ENST00000462584 ENST00000315048(uc004cln.3 uc004clo.3 uc004clm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): GRIN1 (NM_007327) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for GRIN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIN1 |
Additional cDNA sequence: AB208918.1 AB208999.1 AF015730.1 AF015731.1 D13515.1 L05666.1 L13266.1 L13267.1 L13268.1 S57708.1 U08106.1 U08107.1 9 DOTS entries: DT.100776120 DT.70101952 DT.75121435 DT.75173485 DT.92461034 DT.100756689 DT.85104417 DT.92461039 DT.40109790 24/95 AceView cDNA sequences (see all 95): CK821013 U08106 BI793090 L13267 BM723217 R18939 BM710034 BX463601 D13515 L13268 L05666 AW135752 R87721 BM672322 CD609617 AA351537 BM674129 BM715790 NM_000832 BM713383 T28896 BM728978 NM_021569 AF015731
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GRIN1 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21b | ^ | 22a | · | 22b | ^ | 23 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for GRIN1
|
Expression
for GRIN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| GRIN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCAGCTG
About this image
See GRIN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for GRIN1
SOURCE GeneReport for Unigene cluster: Hs.558334
SABiosciences Expression via Pathway-Focused PCR Arrays including GRIN1 (see all 6):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRIN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat GRIN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRIN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN1 |
Orthologs
for GRIN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for GRIN1 gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
GRIN11 |
glutamate receptor, ionotropic, N-methyl D-aspartate more |
83.56(n)
94.54(a) |
|
404296 NM_206979.1 NP_996862.1 |
lizard
(Anolis carolinensis) |
Reptilia |
GRIN16 |
-- |
91(a) |
1 ↔ 1 |
GL343943.1(64350-112646) |
African clawed frog
(Xenopus laevis) |
Amphibia |
NR12 |
unnamed |
75.99(n) |
|
X94081.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.283522 |
Transcribed sequence with moderate similarity to protein more |
75.54(n) |
|
57086016 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nmdar11 , 3 |
N-methyl-D-aspartate selective glutamate
receptor3
NMDA receptor 11 |
47(a)3
60.12(n)1
49.88(a)1 |
|
406651 NM_169059.11 NP_730940.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
nmr-11 , 3 |
Glutamate receptor3
Protein NMR-11 |
35(a)3
43.28(n)1
36.19(a)1 |
|
II(5440288-5446577)3
1739291 NM_062632.41 NP_495033.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
GLR51 |
glutamate receptor 3.7 |
40.95(n)
29.39(a) |
|
817801 NM_128799.3 NP_565744.1 |
rice
(Oryza sativa) |
Liliopsida |
----(see all 22) |
glutamate receptor 2.8 precursor, putative, expres...glutamate receptor 2.8 precursor, putative, expres...(see all 22) |
16(a)16(a)(see all 22) |
many ↔ manymany ↔ many(see all 22) |
6(4488430-4492931) 6(4592690-4596979) |
ENSEMBL Gene Tree for GRIN1 (if available)
TreeFam Gene Tree for GRIN1 (if available) |
Paralogs
for GRIN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for GRIN1 gene
- GRIA32 GRIN2D2 GRIK12 GRIA22 GRIK22 GRIA12 GRIK42 GRIK32
- GRIN3A2 GRIN2B2 GRIN2A2 GRIK52 GRIN3B2 GRIN2C2 GRIA42 GRID12
- GRID22
2 SIMAP similar genes for GRIN1 using alignment to 3 protein entries: NMDZ1_HUMAN (see all proteins):GRIK3 GRID2
GRIN1 for paralogs About GeneDecksing
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Genomic Variants
for GRIN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for GRIN1 (140032842 - 140063214 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for GRIN1
2 CNVs: 4663 5415
4 Indels: 47676 13218 29105 29106
Human Gene Mutation Database (HGMD): GRIN1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRIN1 |
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Disorders
/ Diseases
for GRIN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
GRIN1 for disorders About GeneDecksing
OMIM gene information: 138249
OMIM disorders: --
UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586
Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mentalretardation is characterized by significantly below average general intellectual functioning associated withimpairments in adaptative behavior and manifested during the developmental period
20/48  diseases for GRIN1 (see all 48): About MalaCardspaine syndrome sudden infant death syndrome obsessive-compulsive disorder dysembryoplastic neuroepithelial tumor
amyotrophic lateral sclerosis (als) focal cortical dysplasia amyotrophic lateral sclerosis temporal lobe epilepsy
pathological gambling lateral sclerosis intractable epilepsy ganglioglioma
toxic encephalopathy oral squamous cell carcinoma focal epilepsy anorexia nervosa
intellectual disability squamous cell carcinoma bipolar disorder alcohol dependence
1 disease from the University of Copenhagen DISEASES database for GRIN1:Schizophrenia 10/25 Novoseek disease relationships for GRIN1 gene (see all 25) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
58.6 |
62 |
11109007 (4), 12679240 (4), 12363394 (4), 18792810 (3) (see all 28) |
| neuroepithelial tumors |
58 |
1 |
11355310 (1) |
| hypofunction |
51.3 |
1 |
18296432 (1) |
| ganglioglioma |
47.2 |
2 |
11355310 (1), 7666058 (1) |
| bipolar disorder |
40.7 |
12 |
16969270 (4), 17284422 (3), 15952869 (1), 12610658 (1) |
| ocular dominance |
40.1 |
1 |
9547247 (1) |
| epilepsy |
38.4 |
9 |
7618442 (2), 11355310 (1), 10506512 (1), 15030493 (1) (see all 7) |
| epilepsy temporal lobe |
30.8 |
1 |
17919302 (1) |
| huntington disease |
26.6 |
2 |
9100675 (2) |
| dysplasia |
24.5 |
5 |
15030493 (1), 9761306 (1), 10612330 (1), 17899129 (1) (see all 5) |
Genetic Association Database (GAD): GRIN1
Human Genome Epidemiology (HuGE) Navigator: GRIN1 (29 documents)
Export disorders for GRIN1 gene to outside databases
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Publications
for GRIN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for GRIN1 gene, integrated from 9 sources (see all 434):
(articles sorted by number of sources associating them with GRIN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): implications for schizophrenia. (PubMed id 12363394)1, 4, 9 Tani A....Fukumaki Y. (2002)
- Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia. (PubMed id 11109007)1, 4, 9 Sakurai K....Arinami T. (2000)
- An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. (PubMed id 15841096)1, 4, 9 Qin S....He L. (2005)
- N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case-control analyses. (PubMed id 12707933)1, 4, 9 Martucci L....Kennedy J.L. (2003)
- Cloning and structure of the gene encoding the human N-methyl-D- aspartate receptor (NMDAR1). (PubMed id 7622053)1, 2, 9 Zimmer M.... Spiess J. (1995)
- GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. (PubMed id 15635650)1, 4, 9 Rujescu D....Szegedi A. (2005)
- Association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia. (PubMed id 12679240)1, 4, 9 Begni S....Gennarelli M. (2003)
- Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain. (PubMed id 8316301)1, 2, 9 Tingley W.G.... Huganir R.L. (1993)
- Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German population. (PubMed id 15564900)1, 4, 9 Paus S....Nothen M.M. (2004)
- Alteration of branch site consensus sequence and enhanced pre-mRNA splicing of an NMDAR1 intron not associated with schizophrenia. (PubMed id 12210277)1, 4, 9 Hammond L....Sobell J.L. (2002)
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External Searches for GRIN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing GRIN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing GRIN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GRIN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for GRIN1 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/NMDA_receptor |
|
| | |
About This Section
| Patent Information for GRIN1 gene:
Search GeneIP for patents involving GRIN1
Licensable Technologies for GRIN1 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for GRIN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for GRIN1 | | OriGene shRNA RFP for GRIN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for GRIN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for GRIN1 | | | OriGene Protein Over-expression Lysate for GRIN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for GRIN1 | | OriGene 3'-UTR Clone for GRIN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for GRIN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for GRIN1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for GRIN1 | | OriGene Custom Protein Services for GRIN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat GRIN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing GRIN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat GRIN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat GRIN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat GRIN1 |
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| | Antibodies & Assays for GRIN1 (NMDAR1) |
| | | | Tocris compounds for GRIN1 |
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 | | | GRIN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIN1 |
|  |  |  | | | | ThermoFisher Antibody for GRIN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIN1 |
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