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GRIN1 Gene

protein-coding GIFtS: 72

GC09P139152

glutamate receptor, ionotropic, N-methyl D-aspartate 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NMDAR1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NMDA1 ^²
NMDAR1 ^², ³, ⁵
NR1 ^²
OTTHUMP00000022678 ^²

Descriptions
N-methyl-D-aspartate receptor channel, subunit zeta-1 ^²
N-methyl-D-aspartate receptor subunit NR1 ^³
NMDA receptor 1 ^²
glutamate [NMDA] receptor subunit zeta 1 ^²
glutamate receptor, ionotropic, N-methyl D-aspartate 1 ^²

External Ids
HGNC: 4584¹
Entrez Gene: 2902²
UniProtKB: Q05586³
Ensembl: ENSG00000176884⁷

Search outside databases for aliases for GRIN1 gene

Previous GC identifers: GC09U990032 GC09P131724 GC09P133473 GC09P135390 GC09P137308

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GRIN1:

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members

of the glutamate receptor channel superfamily which are heteromeric protein complexes with

multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in

the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific

factors are thought to control expression of different isoforms, possibly contributing to the

functional diversity of the subunits. Alternatively spliced transcript variants have been

described. [provided by RefSeq]

UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586

Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and

voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in

synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates

neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of

NMDA receptors (By similarity)

Gene Wiki entry for GRIN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRIN1 gene

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

GRIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P139152: (about GC identifiers)

Start:	139,152,663 bp from pter
End:	139,183,029 bp from pter
Size:	30,367 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_024000.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586 (See protein sequence)

Recommended Name: Glutamate [NMDA] receptor subunit zeta-1 precursor

Size: 938 amino acids; 105373 Da

Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B,

GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex

with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction,

synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell

membrane, postsynaptic density (By similarity). Note=Enriched in post-synaptic plasma membrane and

post-synaptic densities (By similarity)

PDB structure from and Proteopedia :

2NR1 (3D)

3BYA (3D)

Secondary accessions: A6NLK7 A6NLR1 P35437 Q12867 Q12868 Q5VSF3 Q5VSF6 Q5VSF7 Q5VSF8

Alternative splicing: 5 isoforms: Q05586-1 Q05586-2 Q05586-3 Q05586-4 Q05586-5

Post-translational modifications:

NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC.

Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state

is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By

similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000823.4 NP_015566.1 NP_067544.1

ENSEMBL proteins:

ENSP00000360616 ENSP00000316696 ENSP00000360615 ENSP00000360601 ENSP00000360608 ENSP00000360614

ENSP00000360610 ENSP00000316915 ENSP00000360605 ENSP00000347576

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NMDAR1 N1, NMDAR1, NMDAR1 C1)
	Human Recombinant Proteins from Abnova (GRIN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	IDA	7685113
GO:0008021	synaptic vesicle	ISS	--
GO:0014069	postsynaptic density	ISS	--
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	IDA	7679115 10480938 17047094

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Antibodies for GRIN1:

	Invitrogen Antibodies for GRIN1
	Millipore Mono- and Polyclonal Antibodies for the study of GRIN1
	Sigma-Aldrich Antibodies for GRIN1
	R&D Systems Antibodies for GRIN1 ("NMDA R, NR1 Subunit")
	Cell Signaling Technology (CST) Antibodies for GRIN1 (NMDAR1)
	Antibodies from Abcam (NMDAR1 N1, NMDAR1, NMDAR1 C1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for GRIN1

Assays for GRIN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q05586

ProtoNet protein and cluster: Q05586

3 Blocks protein families:

IPB001320 Ionotropic glutamate receptor

IPB001508 NMDA receptor signature

IPB001828 Extracellular ligand-binding receptor

UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_007327

Applied Biosystems Silencer® siRNAs for GRIN1

Sigma-Aldrich siRNA and siRNA Panels for GRIN1

Sigma-Aldrich shRNA Panels and shRNA for GRIN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000832
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000832
untagged cDNA clones in CMV expression vector (see all 3): NM_000832

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007327

UniProtKB/Swiss-Prot: NMDZ1_HUMAN, Q05586

Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and

voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in

synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates

neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of

NMDA receptors (By similarity)

Genatlas biochemistry entry for GRIN1:

N-methyl D-aspartate receptor 1,zeta 1subunit glutamate receptor,ubiquitously expressed in all CNS

neurons,hippocampal pyramidal cells and neocortex,basal ganglia,mesencephalic dopaminergic

neurons,throughout development and in adult brain,playing a central role in verbal memory and

cognitive function

13 MGI mutant phenotypes (inferred from 18 alleles) (MGI details for Grin1):

	behavior/neurological	growth/size	hearing/vestibular/ear	homeostasis/metabolism
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system	no phenotypic analysis
normal	reproductive system	respiratory system

5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0004972	contributes to N-methyl-D-aspartate selective glutamate receptor activity	IDA	7679115 7685113
GO:0005216	ion channel activity	IEA	--
GO:0005234	extracellular-glutamate-gated ion channel activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for GRIN1 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Ephrin Receptor Signaling
Calcium Signaling
Synaptic Long Term Potentiation
Glutamate Receptor Signaling
Amyotrophic Lateral Sclerosis Signaling

GeneDecks GRIN1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GRIN1

5/44 Interacting proteins for GRIN1 (ENSP00000360616³ Q05586^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG4	P78352²	STRING (score=.948) MINT-1900350
ERBB4	Q15303¹	EBI-998542, EBI-80371
PLCB4	Q15147¹	EBI-998542, EBI-998637
GRIN2A	ENSP00000332549³	STRING (score=.999)
GRIN2B	ENSP00000279593³	STRING (score=.992)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006812	cation transport	IDA	7685113
GO:0007268	synaptic transmission	ISS	--
GO:0008542	visual learning	ISS	--
GO:0035235	ionotropic glutamate receptor signaling pathway	ISS	--
GO:0042391	regulation of membrane potential	IDA	7679115 7685113 17047094

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GRIN1

Sigma-Aldrich Small Molecules for GRIN1:

Antagonist Blocker Agonist Inhibitor

Compounds for GRIN1 available from Tocris Bioscience

Compound	Action	CAS number
(+)-MK 801 maleate	Non-competitive NMDA antagonist, acts at ion channel site	[77086-22-7]
D-AP5	More active form of DL-AP5 (Cat. No. 0105)	[79055-68-8]
NMDA	Selective NMDA agonist	[6384-92-5]
SDZ 220-581	Competitive NMDA antagonist	[174575-17-8]
L-701,324	NMDA antagonist, acts glycine site	[142326-59-8]

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10/16 Novoseek chemical compound relationships for GRIN1 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ethanol	26.85	40	12824058 (4), 16573586 (4), 12853299 (4), 16179537 (4) (see all 12)
calcium	25.64	18	10217274 (4), 9674563 (1), 10619662 (1), 18796005 (1) (see all 10)
magnesium	20.55	4	9490808 (3), 16372011 (1)
tyrosine	11.32	5	15837820 (1), 12824058 (1), 7666058 (1), 14969737 (1) (see all 5)
picrotoxin	10.30	1	9618545 (1)
oxygen	4.73	1	17196530 (1)
lipid	2.45	3	18323503 (2)
nitric oxide	2.06	10	10945659 (1), 18570704 (1), 18923069 (1), 9394043 (1) (see all 7)
oligonucleotide	0.00	1	9219960 (1)
asparagine	0.00	2	9490808 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRIN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRIN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_007327

Sigma-Aldrich siRNA and siRNA Panels for GRIN1

Sigma-Aldrich shRNA Panels and shRNA for GRIN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000832 NM_007327 NM_021569

REFSEQ mRNAs for GRIN1 gene (3 alternative transcripts):

NM_000832.5 NM_007327.2 NM_021569.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000832 NM_007327 NM_021569

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000832
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000832
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000832

Additional cDNA sequence:

AB208918.1 AB208999.1 AF015730.1 AF015731.1 D13515.1 L05666.1 L13266.1 L13267.1

L13268.1 S57708.1 U08106.1 U08107.1

9 DOTS entries:

DT.100776120 DT.70101952 DT.75121435 DT.75173485 DT.92461034 DT.100756689 DT.85104417 DT.92461039

DT.40109790

24/95 AceView cDNA sequences (see all 95 ):

BI793090 D13515 CK821013 R18939 L05666 U08106 BX463601 BM723217

L13267 L13268 AW135752 BM710034 CD609617 AL134018 BM728978 BX114532

BU728516 BM702272 CB154737 BM548455 NM_021569 AL118662 L13266 CD609615

highest scoring ESTs for GRIN1:

L13266 L13268 AF015730 AF015731 AL119132 AL134018 AW900783 D54481 D54487 L05666

Unigene Cluster for GRIN1:

Glutamate receptor, ionotropic, N-methyl D-aspartate 1

Hs.558334 [show with all ESTs]

Unigene Representative Sequence: L13266

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for GRIN1 (see all 9 )

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20	^	21a	·
SP1:
SP2:									-
SP3:
SP4:																																																			-
SP5:									-

ExUns:	21b	^	22a	·	22b	^	23
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for GRIN1

10 Ensembl transcripts including schematic representations:

ENST00000371561 ENST00000315048 ENST00000371560 ENST00000371546 ENST00000371553 ENST00000371559

ENST00000371555 ENST00000350902 ENST00000371550 ENST00000355410

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GRIN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRIN1

¹ / ² / ³

12 probe-sets matching GRIN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37135_f_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.07	L13268	1.00	1.00	1.00	1
37134_f_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.94	L13266	1.00	1.00	1.00	1
205914_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007327	0.60	1.00	0.82	1
205915_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D13515	0.60	1.00	0.82	1
211125_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF015730	0.80	1.00	0.91	1
210781_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF015731	0.80	1.00	0.91	1
210782_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	L05666	0.80	1.00	0.91	1
205914_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205915_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211125_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210781_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210782_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks GRIN1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCCCAGCTG

SOURCE GeneReport for Unigene cluster: Hs.558334
Expression variation in blood from EXPOLDB for GRIN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GRIN1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRIN1¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	92.07(n) 99.67(a)	494007 NM_001008717.1 NP_001008717.1
rat (Rattus norvegicus)	Grin1¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	90.23(n) 99.25(a)	24408 NM_017010.1 NP_058706.1
mouse (Mus musculus)	Grin1^{1, 5}	2 (12.00 cM)⁵	glutamate receptor, ionotropic, NMDA1 (zeta 1)^{1, 5}	90.72(n)¹ 99.04(a)¹	14810¹ NM_008169.1¹ NP_032195.1¹ AI385669⁵ AK036204⁵ (see all 12)
chicken (Gallus gallus)	GRIN1¹	--	glutamate receptor, ionotropic, N-methyl D-aspartate more	83.56(n) 94.54(a)	404296 NM_206979.1 NP_996862.1
zebrafish (Danio rerio)	Dr.28352²	--	Transcribed sequence with moderate similarity to protein more	75.54(n)	57086016

About this table Species with no ortholog for GRIN1

ENSEMBL Gene Tree for GRIN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRIN1 gene

GRID1² GRID2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/154 NCBI SNPs in GRIN1 are shown (see all 154 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 33)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3181457^1,2	C,F,H	139176349(+)	`ACTATT/GCTGGT`	3	M/I	mis¹		4		EU EA WA	404
--	rs7032504^1,2	A,C	139152018(+)	`ctgacC/Tttagg`	3	--	ng5¹ tfbs³		0	--	--	--	--
--	rs1126448^1,2	H	139177149(+)	`TCTACG/TCCACG`	3	A/S	mis¹ ese³		4		EU EA WA	392
--	rs11146020^1,2	C	139152905(+)	`GAGGAC/GGGGGG`	3	--	ng5¹ ese³ trp³		0	--	--	--	--
--	rs6293^1,2	C,F,H	139171059(+)	`GCCCCA/GGACGG`	3	P/P	syn¹ ese³		5		MN EU EA WA	494
--	rs1126442^1,2	C	139171197(+)	`GCCGTA/GGGCGT`	3	V/V	syn¹		0	--	--	--	--
	rs2301363^1,2	A,C,F,H	139154252(+)	`GAGGGC/TCCCTG`	3	--	int¹		5		EA WA	478
	rs10870198^1,2	A,C,F,H	139162141(+)	`CCTCCA/GAACGG`	3	--	int¹		4		EU EA WA	418
	rs2071644^1,2	C,F,H	139178730(+)	`GGCCTG/ATACAG`	3	--	int¹		4		EU EA WA	418
--	rs4880215^1,2	A,F,H	139156850(+)	`AGTCAC/AACACA`	3	--	int¹		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for GRIN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 138249

10/25 Novoseek disease relationships for GRIN1 gene (see all 25 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroepithelial tumors	59.48	1	11355310 (1)
schizophrenia	58.38	58	11109007 (4), 12679240 (4), 12363394 (4), 17728671 (3) (see all 26)
hypofunction	53.14	1	18296432 (1)
ganglioglioma	48.97	2	11355310 (1), 7666058 (1)
ocular dominance	41.84	1	9547247 (1)
epilepsy	40.43	9	7618442 (2), 11355310 (1), 10506512 (1), 15030493 (1) (see all 7)
bipolar disorder	38.45	12	16969270 (4), 17284422 (3), 15952869 (1), 12610658 (1)
epilepsy temporal lobe	32.86	1	17919302 (1)
huntington disease	28.80	2	9100675 (2)
dysplasia	26.51	5	15030493 (1), 9761306 (1), 10612330 (1), 17899129 (1) (see all 5)

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Genetic Association Database: GRIN1
Human Genome Epidemiology Navigator: GRIN1 (21 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/324 PubMed articles for GRIN1 gene (see all 324 ):

Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): implications for schizophrenia. (PubMed id 12363394)^{1, 3, 6} Tani A....Fukumaki Y. (2002)
Mutation analysis of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia. (PubMed id 11109007)^{1, 3, 6} Sakurai K....Arinami T. (2000)
An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. (PubMed id 15841096)^{1, 3, 6} Qin S....He L. (2005)
N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) in schizophrenia: TDT and case-control analyses. (PubMed id 12707933)^{1, 3, 6} Martucci L....Kennedy J.L. (2003)
Cloning and structure of the gene encoding the human N-methyl-D- aspartate receptor (NMDAR1). (PubMed id 7622053)^{1, 3, 4} Zimmer M.... Spiess J. (1995)
GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. (PubMed id 15635650)^{1, 3, 6} Rujescu D....Szegedi A. (2005)
Association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia. (PubMed id 12679240)^{1, 3, 6} Begni S....Gennarelli M. (2003)
Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain. (PubMed id 8316301)^{1, 3, 4} Tingley W.G.... Huganir R.L. (1993)
Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German population. (PubMed id 15564900)^{1, 3, 6} Paus S....Nothen M.M. (2004)
Alteration of branch site consensus sequence and enhanced pre-mRNA splicing of an NMDAR1 intron not associated with schizophrenia. (PubMed id 12210277)^{1, 3, 6} Hammond L....Sobell J.L. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2902	HGNC: 4584	AceView: GRIN1	Ensembl:ENSG00000176884	euGenes: HUgn2902
ECgene: GRIN1	H-InvDB: GRIN1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Wikipedia	http://en.wikipedia.org/wiki/NMDA_receptor

Licensable Technologies for GRIN1
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Licensable Technologies for GRIN1 gene:

Tufts University:

Treatment of Obsessive-Compulsive Disorder and Compulsive Disorders (including Over-Eating, Alcoholism & Smoking)

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Products for GRIN1:

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GRIN1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for GRIN1

Summaries
for GRIN1

Genomic Location
for GRIN1

Proteins
for GRIN1

Protein Domains/
Families
for GRIN1

Gene Function
for GRIN1

Pathways & Interactions
for GRIN1

Drugs & Compounds
for GRIN1

Transcripts
for GRIN1

Expression
for GRIN1

Orthologs
for GRIN1

Paralogs
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SNPs/Variants
for GRIN1

Disorders & Mutations
for GRIN1

Medical News
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Publications
for GRIN1

Search for GRIN1

Genome Databases showing GRIN1

Other Databases showing GRIN1

Specialized Databases showing GRIN1

Licensable Technologies
for GRIN1

Services
for GRIN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRIN1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor GRIN1

Summariesfor GRIN1

Genomic Locationfor GRIN1

Proteinsfor GRIN1

Protein Domains/Familiesfor GRIN1

Gene Functionfor GRIN1

Pathways & Interactionsfor GRIN1

Drugs & Compoundsfor GRIN1

Transcriptsfor GRIN1

Expression for GRIN1

Orthologsfor GRIN1

Paralogsfor GRIN1

SNPs/Variantsfor GRIN1

Disorders & Mutationsfor GRIN1

Medical Newsfor GRIN1

Publicationsfor GRIN1

Search for GRIN1

Genome Databases showing GRIN1

Other Databases showing GRIN1

Specialized Databases showing GRIN1

Licensable Technologiesfor GRIN1

Servicesfor GRIN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRIN1

Summaries
for GRIN1

Genomic Location
for GRIN1

Proteins
for GRIN1

Protein Domains/
Families
for GRIN1

Gene Function
for GRIN1

Pathways & Interactions
for GRIN1

Drugs & Compounds
for GRIN1

Transcripts
for GRIN1

Expression
for GRIN1

Orthologs
for GRIN1

Paralogs
for GRIN1

SNPs/Variants
for GRIN1

Disorders & Mutations
for GRIN1

Medical News
for GRIN1

Publications
for GRIN1

Licensable Technologies
for GRIN1

Services
for GRIN1