Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



GRIK5 Gene

protein-coding   GIFtS: 65
GCID: GC19M042502

Glutamate Receptor, Ionotropic, Kainate 5


(Previous symbol: GRIK2)
  See GRIK5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Glutamate Receptor, Ionotropic, Kainate 51 2     GluK52 3
GRIK21 2 3     KA22 3
Excitatory Amino Acid Receptor 22 3     Glutamate Receptor Ionotropic, Kainate 52
Glutamate Receptor KA-22 3     Glutamate Receptor KA22
EAA22 3     

External Ids:    HGNC: 45831   Entrez Gene: 29012   Ensembl: ENSG000001057377   OMIM: 6002835   UniProtKB: Q164783   

Export aliases for GRIK5 gene to outside databases

Previous GC identifers: GC19M043142 GC19M042894 GC19M047178 GC19M047194 GC19M038934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for GRIK5 Gene:
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the
major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels
and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric
kainate-preferring ionic channels with the subunits encoded by related gene family members. (provided by RefSeq,
Jul 2008)

GeneCards Summary for GRIK5 Gene:
GRIK5 (glutamate receptor, ionotropic, kainate 5) is a protein-coding gene. Diseases associated with GRIK5 include schizophrenia. GO annotations related to this gene include PDZ domain binding and identical protein binding. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIK5_HUMAN, Q16478
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA
>> NMDA = 1S,3R-ACPD

summary for GRIK5 Gene:
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors
contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and
long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an
extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips
into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIK5 gene promoter:
         E2F-3a   c-Fos   AP-1   ATF-2   E2F-2   E2F-1   E2F   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIK5 promoter sequence
   Search Chromatin IP Primers for GRIK5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

GRIK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIK5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042502:  view genomic region     (about GC identifiers)

Start:
42,502,473 bp from pter      End:
42,573,650 bp from pter
Size:
71,178 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GRIK5_HUMAN, Q16478 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, kainate 5 precursor  
Size: 980 amino acids; 109265 Da
Subunit: Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions),
GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By
similarity)
Secondary accessions: Q8WWG8
Alternative splicing: 2 isoforms:  Q16478-1   Q16478-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for GRIK5: NX_Q16478

Explore proteomics data for GRIK5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn219, Asn271, Asn285, Asn322, Asn372, Asn394, Asn400, Asn407, Asn414, Asn478
  • Modification sites at PhosphoSitePlus

  • See GRIK5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002079.3  
    ENSEMBL proteins: 
     ENSP00000262895   ENSP00000470251   ENSP00000301218   ENSP00000469135  
    Reactome Protein details: Q16478

    GRIK5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for GRIK5
    GenScript Custom Purified and Recombinant Proteins Services for GRIK5
    Novus Biologicals GRIK5 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for GRIK5

     
    Search eBioscience for Proteins for GRIK5 

    GRIK5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIK5
    Browse R&D Systems for Antibodies
    OriGene Antibodies for GRIK5
    OriGene Custom Antibody Services for GRIK5
    Novus Biologicals GRIK5 Antibodies
    Abcam antibodies for GRIK5
    Cloud-Clone Corp. Antibodies for GRIK5
    ThermoFisher Antibodies for GRIK5
    LSBio Antibodies in human, mouse, rat for GRIK5

    GRIK5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for GRIK5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for GRIK5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for GRIK5
    Cloud-Clone Corp. CLIAs for GRIK5
    Search eBioscience for ELISAs for GRIK5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluK5
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry Q16478

    ProtoNet protein and cluster: Q16478

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIK5_HUMAN, Q16478
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily


    Find genes that share domains with GRIK5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIK5_HUMAN, Q16478
    Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
    central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
    according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA
    >> NMDA = 1S,3R-ACPD

         Genatlas biochemistry entry for GRIK5:
    glutamate receptor KA2,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding ----
    GO:0008066glutamate receptor activity ----
         
    Find genes that share ontologies with GRIK5           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Grik5):
     behavior/neurological  homeostasis/metabolism  integument  nervous system 

    Find genes that share phenotypes with GRIK5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Grik5tm1Cont for GRIK5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIK5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIK5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for GRIK5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for GRIK5

    miRNA
    Products:
        
    miRTarBase miRNAs that target GRIK5:
    hsa-mir-186-5p (MIRT045128)

    Block miRNA regulation of human, mouse, rat GRIK5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIK5 (see all 12):
    hsa-miR-4311 hsa-miR-615-5p hsa-miR-376b hsa-miR-198 hsa-miR-376a hsa-miR-1253 hsa-miR-629* hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIK5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for GRIK5
    Predesigned siRNA for gene silencing in human, mouse, rat GRIK5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for GRIK5

    Clone
    Products:
         
    OriGene clones in human, mouse for GRIK5 (see all 6)
    OriGene ORF clones in mouse, rat for GRIK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRIK5 (NM_002088)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for GRIK5
    Browse ESI BIO Cell Lines and PureStem Progenitors for GRIK5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GRIK5_HUMAN, Q16478: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0008328ionotropic glutamate receptor complex ----
    GO:0014069postsynaptic density IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with GRIK5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for GRIK5 About    
    See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2ADP signalling through P2Y purinoceptor 12
    Activation of Kainate Receptors upon glutamate binding0.68
    Ionotropic activity of Kainate Receptors0.00
    Activation of Ca-permeable Kainate Receptor0.35
    3Circadian entrainment
    Glutamatergic synapse0.39
    4Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    5Glutamic acid signaling
    Glutamic acid signaling


    Find genes that share SuperPaths with GRIK5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for GRIK5
        CREB Pathway
    Intracellular Calcium Signaling

    1 Reactome Pathway for GRIK5
        Activation of Ca-permeable Kainate Receptor


    2 Kegg Pathways  (Kegg details for GRIK5):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIK5: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIK5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for GRIK5 (Q164782, 3 ENSP000002628954) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLM1Q8NBJ42, 3MINT-64976 I2D: score=4 
    LRSAM1Q6UWE02, 3, ENSP000003004174MINT-64685 I2D: score=4 STRING: ENSP00000300417
    GPAA1O432922, 3, ENSP000003472064MINT-63134 I2D: score=4 STRING: ENSP00000347206
    GRID2O434243, ENSP000002820204I2D: score=3 STRING: ENSP00000282020
    GRIK2Q130023, ENSP000003970264I2D: score=2 STRING: ENSP00000397026
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006621protein retention in ER lumen IEA--
    GO:0006810transport ----
    GO:0007268synaptic transmission TAS--
    GO:0031630regulation of synaptic vesicle fusion to presynaptic membrane IEA--
    GO:0034220ion transmembrane transport IBA--

    Find genes that share ontologies with GRIK5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIK5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Domoic acid Potent, selective kainate agonist [14277-97-5]
    Kainic acidPotent excitant and neurotoxin[487-79-6]
    CNQXPotent AMPA/kainate antagonist[115066-14-3]
    UBP 302 Selective, potent kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078) [745055-91-8]
    ACETPotent antagonist of GluR5-containing kainate receptors[936095-50-0]

    1 DrugBank Compound for GRIK5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--2850065 17139284 17016423 11058796

    6 IUPHAR Ligands for GRIK5 (GluK5)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H](2S,4R)-4-methylglutamate
    NoneNone--
    kainate
    AgonistFull agonist--
    domoic acid
    AgonistFull agonist--
    dysiherbaine
    AgonistFull agonist--
    SYM2081
    AgonistFull agonist--
    [3H]kainate
    NoneNone--

    4 Novoseek inferred chemical compound relationships for GRIK5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kainate 84.4 30 8552236 (3), 16325263 (2), 8744443 (2), 8288598 (2) (see all 16)
    glutamate 73.1 22 7527545 (2), 14511640 (2), 19526364 (1), 14662797 (1) (see all 13)
    nmda 58.8 4 20061814 (1), 18923069 (1), 18462708 (1), 7518497 (1)
    gaba 23.1 2 18923069 (1)



    Find genes that share compounds with GRIK5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for GRIK5 gene: 
    NM_002088.4  

    Unigene Cluster for GRIK5:

    Glutamate receptor, ionotropic, kainate 5
    Hs.367799  [show with all ESTs]
    Unigene Representative Sequence: NM_002088
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454993 ENST00000262895(uc002osi.1 uc002osj.1) ENST00000593562
    ENST00000602210 ENST00000301218(uc010eib.1) ENST00000594528
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat GRIK5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate GRIK5 (see all 12):
    hsa-miR-4311 hsa-miR-615-5p hsa-miR-376b hsa-miR-198 hsa-miR-376a hsa-miR-1253 hsa-miR-629* hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidGRIK5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for GRIK5
    Predesigned siRNA for gene silencing in human, mouse, rat GRIK5
    Clone
    Products:
         
    OriGene clones in human, mouse for GRIK5 (see all 6)
    OriGene ORF clones in mouse, rat for GRIK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: GRIK5 (NM_002088)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for GRIK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIK5
      QuantiTect SYBR Green Assays in human, mouse, rat GRIK5
      QuantiFast Probe-based Assays in human, mouse, rat GRIK5

    Additional mRNA sequence: 

    BC037358.1 BC052975.1 BC131717.1 S40369.1 

    3 DOTS entries:

    DT.405866  DT.95364180  DT.95150185 

    Selected AceView cDNA sequences (see all 58):

    R20289 AI248879 BQ070572 NM_002088 AL134360 AL044131 BC052975 T72582 
    AI248896 BC037358 BG151527 AJ249209 BG055815 BG472964 AL137705 BG149313 
    BM548099 BM672861 S40369 F12191 BC042987 BI046219 CD300434 AA977136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    GRIK5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTCATAT
    GRIK5 Expression
    About this image

    GRIK5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIK5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367799
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIK5: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for GRIK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIK5
    QuantiTect SYBR Green Assays in human, mouse, rat GRIK5
    QuantiFast Probe-based Assays in human, mouse, rat GRIK5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for GRIK5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grik51 , 5 glutamate receptor, ionotropic, kainate 5 (gamma 2)1, 5 91.76(n)1
    98.26(a)1
      7 (13.73 cM)5
    148091  NM_008168.21  NP_032194.21 
     250098535 
    lizard
    (Anolis carolinensis)
    Reptilia GRIK56
    glutamate receptor, ionotropic, kainate 5
    86(a)
    1 ↔ 1
    GL344447.1(1486-26154)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grik51 glutamate receptor, ionotropic, kainate 5 74.35(n)
    85.59(a)
      100497490  XM_002936400.2  XP_002936446.1 
    zebrafish
    (Danio rerio)
    Actinopterygii grik51 glutamate receptor, ionotropic, kainate 5 74.77(n)
    84.59(a)
      798791  NM_001245961.1  NP_001232890.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111553 kainate selective glutamate receptor 53(a)
    (best of 9)
        --


    ENSEMBL Gene Tree for GRIK5 (if available)
    TreeFam Gene Tree for GRIK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for GRIK5 gene
    GRIA32  GRIK12  GRIA22  GRIA42  GRIK22  GRID12  GRIA12  GRIK32  
    GRIK42  GRID22  
    8 SIMAP similar genes for GRIK5 using alignment to 2 protein entries:     GRIK5_HUMAN (see all proteins):
    GRIK4    GRIK2    GRIK3    GRIK1    GRIA1    GRIA2
    GRIA4    GRIA3

    Find genes that share paralogs with GRIK5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for GRIK5 (see all 1079)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831634161,2
    --42502105(+) ACCCCA/GGCCCA 1 -- ds50010--------
    rs1874489681,2
    --42502415(+) GCCCCA/GGGGAC 1 -- ds50010--------
    rs1513365981,2
    --42502463(+) AGACGG/TTATCC 1 -- ds50010--------
    rs1920503991,2
    --42502673(+) AGAAGC/TGTGGG 1 -- ut310--------
    rs1848376231,2
    --42502930(+) TCCTGG/TCCCGC 1 -- ut310--------
    rs1881025291,2
    --42503561(+) TTCTTA/CCTTCT 1 -- int10--------
    rs1126115491,2
    C,F--42503604(+) TATCTC/TCCCCG 1 -- int12Minor allele frequency- T:0.07CSA WA 120
    rs1923321561,2
    --42503637(+) CCTCTA/CCCCAC 1 -- int10--------
    rs1406018841,2
    --42503716(+) CCTCTC/GTTTCC 1 -- int10--------
    rs1844539471,2
    --42503759(+) AGTTCC/TTCCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for GRIK5 (42502473 - 42573650 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for GRIK5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677186CNV Deletion23128226
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    esv24829CNV Loss19812545
    dgv3883n71CNV Loss21882294
    nsv522854CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIK5
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIK5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600283    OMIM disorders: --

    1 disease for GRIK5:    
    About MalaCards
    schizophrenia


    Find genes that share disorders with GRIK5           About GenesLikeMe

    1 Novoseek inferred disease relationship for GRIK5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 41.3 5 16325263 (3), 9099808 (1), 15886719 (1)

    Genetic Association Database (GAD): GRIK5
    Human Genome Epidemiology (HuGE) Navigator: GRIK5 (3 documents)

    Export disorders for GRIK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for GRIK5 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with GRIK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. (PubMed id 7527545)1, 3, 9 Szpirer C....Copeland N.G. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PubMed id 16325263)1, 4, 9 Shibata H....Fukumaki Y. (Psychiatry Res 2006)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4, 9 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. Genome-wide association study on bipolar disorder in the Bulgarian population. (PubMed id 21771265)1, 4 Yosifova A....Nakamura Y. (Genes Brain Behav. 2011)
    5. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PubMed id 19125103)1, 4 Arai S....Fukumaki Y. (Psychiatr. Genet. 2009)
    6. Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. (PubMed id 1321949)1, 2 Kamboj R.K.... Wosnick M.A. (Mol. Pharmacol. 1992)
    7. Trafficking and surface expression of the glutamate receptor subunit, KA2. (PubMed id 14511640)1, 9 Hayes D.M....Roche K.W. (Biochem. Biophys. Res. Commun. 2003)
    8. Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies. (PubMed id 8288598)1, 9 Wenthold R.J....Petralia R.S. (J. Biol. Chem. 1994)
    9. Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. (PubMed id 9099808)1, 9 Porter R.H....Harrison P.J. (Brain Res. 1997)
    10. Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. (PubMed id 11279111)1, 9 Mehta S....Marshall J. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2901 HGNC: 4583 AceView: GRIK5 Ensembl:ENSG00000105737 euGenes: HUgn2901
    ECgene: GRIK5 Kegg: 2901 H-InvDB: GRIK5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for GRIK5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for GRIK5 gene:
    Search GeneIP for patents involving GRIK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of GRIK5
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for GRIK5 (KA2/GRIK5)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for GRIK5   OriGene RNAi products in human, mouse, rat for GRIK5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for GRIK5  
     OriGene qSTAR qPCR primer pairs in human, mouse for GRIK5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for GRIK5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for GRIK5   OriGene Custom Protein Services for GRIK5  

     
     
     Block miRNA regulation of human, mouse, rat GRIK5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing GRIK5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIK5 Predesigned siRNA for gene silencing in human, mouse, rat GRIK5
     QuantiFast Probe-based Assays in human, mouse, rat GRIK5 QuantiTect SYBR Green Assays in human, mouse, rat GRIK5
     PCR Arrays including human, mouse, rat GRIK5 Search Chromatin IP Primers for GRIK5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat GRIK5  GeneGlobe Interaction Network for GRIK5
     Regulatory tfbs in GRIK5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for GRIK5 GenScript cDNA clones with any tag delivered in your preferred vector for GRIK5
     GenScript Custom Assay Services for GRIK5 GenScript Custom overexpressing Cell Line Services for GRIK5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for GRIK5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     GRIK5 antibodies
     GRIK5 proteins
     Antibodies for GRIK5
     See all of Abcam's Antibodies, Kits and Proteins for GRIK5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for GRIK5
     Antibodies for GRIK5
     ELISAs for GRIK5
     CLIAs for GRIK5



     Browse ESI BIO Cell Lines and PureStem Progenitors for GRIK5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK5
     SwitchGear 3'UTR luciferase reporter plasmids for GRIK5
     SwitchGear Promoter luciferase reporter plasmids for GRIK5
     ThermoFisher Antibodies for GRIK5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat GRIK5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIK5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for GRIK5
     LSBio Antibodies in human, mouse, rat for GRIK5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for GRIK5
      Search eBioscience for proteins for GRIK5
      Search eBioscience for elisas for GRIK5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      GRIK5 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4