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Aliases for GRIK5 Gene

Aliases for GRIK5 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 5 2 3
  • Glutamate Receptor, Ionotropic, Kainate 5 2 3 5
  • Excitatory Amino Acid Receptor 2 3 4
  • GRIK2 3 4
  • GluK5 3 4
  • EAA2 3 4
  • KA2 3 4
  • Glutamate Receptor KA-2 4
  • Glutamate Receptor KA2 3

External Ids for GRIK5 Gene

Previous HGNC Symbols for GRIK5 Gene

  • GRIK2

Previous GeneCards Identifiers for GRIK5 Gene

  • GC19M043142
  • GC19M042894
  • GC19M047178
  • GC19M047194
  • GC19M042502
  • GC19M038934

Summaries for GRIK5 Gene

Entrez Gene Summary for GRIK5 Gene

  • This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for GRIK5 Gene

GRIK5 (Glutamate Ionotropic Receptor Kainate Type Subunit 5) is a Protein Coding gene. Diseases associated with GRIK5 include schizophrenia and autosomal recessive non-syndromic intellectual disability. Among its related pathways are Circadian entrainment and Peptide ligand-binding receptors. GO annotations related to this gene include identical protein binding and PDZ domain binding. An important paralog of this gene is GRID1.

UniProtKB/Swiss-Prot for GRIK5 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

Tocris Summary for GRIK5 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

Gene Wiki entry for GRIK5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK5 Gene

Genomics for GRIK5 Gene

Regulatory Elements for GRIK5 Gene

Enhancers for GRIK5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GRIK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIK5 Gene

Chromosome:
19
Start:
41,998,316 bp from pter
End:
42,071,804 bp from pter
Size:
73,489 bases
Orientation:
Minus strand

Genomic View for GRIK5 Gene

Genes around GRIK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK5 Gene

Proteins for GRIK5 Gene

  • Protein details for GRIK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16478-GRIK5_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 5
    Protein Accession:
    Q16478
    Secondary Accessions:
    • Q8WWG8

    Protein attributes for GRIK5 Gene

    Size:
    980 amino acids
    Molecular mass:
    109265 Da
    Quaternary structure:
    • Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).

    Alternative splice isoforms for GRIK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK5 Gene

Proteomics data for GRIK5 Gene at MOPED

Post-translational modifications for GRIK5 Gene

  • Glycosylation at Asn 219, Asn 271, Asn 285, Asn 322, Asn 372, Asn 394, Asn 400, Asn 407, Asn 414, and Asn 478
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK5 Gene

Antibody Products

No data available for DME Specific Peptides for GRIK5 Gene

Domains & Families for GRIK5 Gene

Gene Families for GRIK5 Gene

Suggested Antigen Peptide Sequences for GRIK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16478

UniProtKB/Swiss-Prot:

GRIK5_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.
genes like me logo Genes that share domains with GRIK5: view

Function for GRIK5 Gene

Molecular function for GRIK5 Gene

GENATLAS Biochemistry:
glutamate receptor KA2,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

Gene Ontology (GO) - Molecular Function for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015276 ligand-gated ion channel activity TAS --
genes like me logo Genes that share ontologies with GRIK5: view
genes like me logo Genes that share phenotypes with GRIK5: view

Animal Models for GRIK5 Gene

MGI Knock Outs for GRIK5:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRIK5

CRISPR Products

miRNA for GRIK5 Gene

miRTarBase miRNAs that target GRIK5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIK5 Gene

Localization for GRIK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK5 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIK5 Gene COMPARTMENTS Subcellular localization image for GRIK5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with GRIK5: view

Pathways & Interactions for GRIK5 Gene

genes like me logo Genes that share pathways with GRIK5: view

Gene Ontology (GO) - Biological Process for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043113 receptor clustering IEA --
GO:0043525 positive regulation of neuron apoptotic process IEA --
GO:0060079 excitatory postsynaptic potential IEA --
genes like me logo Genes that share ontologies with GRIK5: view

No data available for SIGNOR curated interactions for GRIK5 Gene

Drugs & Compounds for GRIK5 Gene

(10) Drugs for GRIK5 Gene - From: DrugBank, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Domoic acid Experimental Pharma Full agonist, Agonist Potent, selective kainate agonist 0
kainate Pharma Full agonist, Agonist 0
[<sup>3</sup>H](2S,4R)-4-methylglutamate Pharma 0
[<sup>3</sup>H]kainate Pharma 0
dysiherbaine Pharma Full agonist, Agonist 0

(5) Additional Compounds for GRIK5 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-(-)-5-Iodowillardiine
140187-25-3
Kainic acid
487-79-6
SYM 2081
31137-74-3

(5) Tocris Compounds for GRIK5 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine Highly potent, subtype-selective kainate agonist 140187-25-3
ATPA Selective, potent GluR5 agonist 140158-50-5
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
SYM 2081 Highly selective kainate agonist 31137-74-3
genes like me logo Genes that share compounds with GRIK5: view

Transcripts for GRIK5 Gene

Unigene Clusters for GRIK5 Gene

Glutamate receptor, ionotropic, kainate 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK5 Gene

No ASD Table

Relevant External Links for GRIK5 Gene

GeneLoc Exon Structure for
GRIK5
ECgene alternative splicing isoforms for
GRIK5

Expression for GRIK5 Gene

mRNA expression in normal human tissues for GRIK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK5 Gene

This gene is overexpressed in Testis (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIK5 Gene



SOURCE GeneReport for Unigene cluster for GRIK5 Gene Hs.367799

genes like me logo Genes that share expression patterns with GRIK5: view

Protein tissue co-expression partners for GRIK5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRIK5 Gene

Orthologs for GRIK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK5 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GRIK5 35
  • 93.71 (n)
  • 99.18 (a)
GRIK5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grik5 35
  • 91.76 (n)
  • 98.26 (a)
Grik5 16
Grik5 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRIK5 35
  • 99.67 (n)
  • 99.44 (a)
GRIK5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grik5 35
  • 91.66 (n)
  • 98.26 (a)
cow
(Bos Taurus)
Mammalia GRIK5 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIK5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK5 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIK5 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik5 35
  • 74.35 (n)
  • 85.59 (a)
zebrafish
(Danio rerio)
Actinopterygii grik5 35
  • 74.77 (n)
  • 84.59 (a)
grik5 36
  • 80 (a)
OneToMany
GRIK5 (2 of 2) 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11155 37
  • 53 (a)
CG15627 37
  • 33 (a)
CG4226 37
  • 28 (a)
CG5621 37
  • 35 (a)
CG9935 37
  • 45 (a)
clumsy 37
  • 35 (a)
Glu-RIIA 37
  • 30 (a)
Glu-RIIB 37
  • 27 (a)
Kai-RIA 37
  • 35 (a)
CG11155 36
  • 39 (a)
ManyToMany
CG9935 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-4 37
  • 34 (a)
Species with no ortholog for GRIK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK5 Gene

ENSEMBL:
Gene Tree for GRIK5 (if available)
TreeFam:
Gene Tree for GRIK5 (if available)

Paralogs for GRIK5 Gene

Paralogs for GRIK5 Gene

(8) SIMAP similar genes for GRIK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIK5: view

Variants for GRIK5 Gene

Sequence variations from dbSNP and Humsavar for GRIK5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_047000 -
rs12978402 -- 42,018,027(+) ACTGA(C/T)TCCCg intron-variant
rs12978933 -- 42,011,053(+) cctcc(A/G/T)gcctc intron-variant
rs8099939 -- 42,016,956(+) ATGAT(G/T)ATAAT intron-variant
rs12984336 -- 42,036,078(+) ttttg(A/G)gacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK5 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3883n71 CNV Loss 21882294
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
esv2677186 CNV Deletion 23128226
esv24829 CNV Loss 19812545

Variation tolerance for GRIK5 Gene

Residual Variation Intolerance Score: 9.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIK5 Gene

HapMap Linkage Disequilibrium report
GRIK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK5 Gene

Disorders for GRIK5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRIK5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search GRIK5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRIK5

Genetic Association Database (GAD)
GRIK5
Human Genome Epidemiology (HuGE) Navigator
GRIK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIK5
genes like me logo Genes that share disorders with GRIK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK5 Gene

Publications for GRIK5 Gene

  1. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. (PMID: 7527545) Szpirer C. … Copeland N.G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 23 67
  2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23
  3. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H. … Fukumaki Y. (Psychiatry Res 2006) 3 23
  4. Trafficking and surface expression of the glutamate receptor subunit, KA2. (PMID: 14511640) Hayes D.M. … Roche K.W. (Biochem. Biophys. Res. Commun. 2003) 3 23
  5. Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. (PMID: 11279111) Mehta S. … Marshall J. (J. Biol. Chem. 2001) 3 23

Products for GRIK5 Gene

Sources for GRIK5 Gene

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