Aliases for GRIK5 Gene
External Ids for GRIK5 Gene
Previous HGNC Symbols for GRIK5 Gene
Previous GeneCards Identifiers for GRIK5 Gene
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for GRIK5 Gene
GRIK5 (Glutamate Ionotropic Receptor Kainate Type Subunit 5) is a Protein Coding gene. Diseases associated with GRIK5 include schizophrenia and autosomal recessive non-syndromic intellectual disability. Among its related pathways are Circadian entrainment and Peptide ligand-binding receptors. GO annotations related to this gene include identical protein binding and PDZ domain binding. An important paralog of this gene is GRID1.
UniProtKB/Swiss-Prot for GRIK5 Gene
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.