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Aliases for GRIK5 Gene

Aliases for GRIK5 Gene

  • Glutamate Receptor, Ionotropic, Kainate 5 2 3
  • Excitatory Amino Acid Receptor 2 3 4
  • GRIK2 3 4
  • GluK5 3 4
  • EAA2 3 4
  • KA2 3 4
  • Glutamate Receptor Ionotropic, Kainate 5 3
  • Glutamate Receptor KA-2 4
  • Glutamate Receptor KA2 3

External Ids for GRIK5 Gene

Previous HGNC Symbols for GRIK5 Gene

  • GRIK2

Previous GeneCards Identifiers for GRIK5 Gene

  • GC19M043142
  • GC19M042894
  • GC19M047178
  • GC19M047194
  • GC19M042502
  • GC19M038934

Summaries for GRIK5 Gene

Entrez Gene Summary for GRIK5 Gene

  • This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for GRIK5 Gene

GRIK5 (Glutamate Receptor, Ionotropic, Kainate 5) is a Protein Coding gene. Diseases associated with GRIK5 include schizophrenia. Among its related pathways are CREB Pathway and CREB Pathway. GO annotations related to this gene include identical protein binding and PDZ domain binding. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRIK5 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD

Tocris Summary for GRIK5 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips into the membrane from the cytoplasmic face to form the pore.

Gene Wiki entry for GRIK5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK5 Gene

Genomics for GRIK5 Gene

Regulatory Elements for GRIK5 Gene

Genomic Location for GRIK5 Gene

Start:
41,998,316 bp from pter
End:
42,070,210 bp from pter
Size:
71,895 bases
Orientation:
Minus strand

Genomic View for GRIK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK5 Gene

Proteins for GRIK5 Gene

  • Protein details for GRIK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16478-GRIK5_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 5
    Protein Accession:
    Q16478
    Secondary Accessions:
    • Q8WWG8

    Protein attributes for GRIK5 Gene

    Size:
    980 amino acids
    Molecular mass:
    109265 Da
    Quaternary structure:
    • Tetramer of two or more different subunits. Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity (By similarity).

    Alternative splice isoforms for GRIK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIK5 Gene

Proteomics data for GRIK5 Gene at MOPED

Post-translational modifications for GRIK5 Gene

  • Glycosylation at Asn219, Asn271, Asn285, Asn322, Asn372, Asn394, Asn400, Asn407, Asn414, and Asn478
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIK5 Gene

Domains for GRIK5 Gene

Gene Families for GRIK5 Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for GRIK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16478

UniProtKB/Swiss-Prot:

GRIK5_HUMAN :
  • Q16478
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.
genes like me logo Genes that share domains with GRIK5: view

Function for GRIK5 Gene

Molecular function for GRIK5 Gene

GENATLAS Biochemistry: glutamate receptor KA2,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD

Gene Ontology (GO) - Molecular Function for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding --
GO:0008066 glutamate receptor activity --
GO:0015277 kainate selective glutamate receptor activity IDA 1321949
genes like me logo Genes that share ontologies with GRIK5: view
genes like me logo Genes that share phenotypes with GRIK5: view

Animal Models for GRIK5 Gene

MGI Knock Outs for GRIK5:

miRNA for GRIK5 Gene

miRTarBase miRNAs that target GRIK5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRIK5 Gene

Localization for GRIK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK5 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIK5 Gene COMPARTMENTS Subcellular localization image for GRIK5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0008328 ionotropic glutamate receptor complex --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with GRIK5: view

Pathways for GRIK5 Gene

genes like me logo Genes that share pathways with GRIK5: view

Gene Ontology (GO) - Biological Process for GRIK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006621 protein retention in ER lumen IEA --
GO:0007165 signal transduction --
GO:0007268 synaptic transmission TAS --
GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane IEA --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIK5: view

Compounds for GRIK5 Gene

(5) Tocris Compounds for GRIK5 Gene

Compound Action Cas Number
ACET Potent antagonist of GluR5-containing kainate receptors [936095-50-0]
ATPA Selective, potent GluR5 agonist [140158-50-5]
CNQX Potent AMPA/kainate antagonist [115066-14-3]
Kainic acid Potent excitant and neurotoxin [487-79-6]
UBP 310 GLUK5 antagonist [902464-46-4]

(1) Drugbank Compounds for GRIK5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(6) IUPHAR Ligand for GRIK5 Gene

Ligand Type Action Affinity Pubmed IDs
SYM2081 Inhibitor Inhibition 5.5
[3H](2S,4R)-4-methylglutamate None None
kainate Agonist Full agonist
domoic acid Agonist Full agonist
dysiherbaine Agonist Full agonist
[3H]kainate None None

(4) Novoseek inferred chemical compound relationships for GRIK5 Gene

Compound -log(P) Hits PubMed IDs
kainate 84.4 23
glutamate 73.1 15
nmda 58.8 4
gaba 23.1 1
genes like me logo Genes that share compounds with GRIK5: view

Transcripts for GRIK5 Gene

Unigene Clusters for GRIK5 Gene

Glutamate receptor, ionotropic, kainate 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK5 Gene

No ASD Table

Relevant External Links for GRIK5 Gene

GeneLoc Exon Structure for
GRIK5
ECgene alternative splicing isoforms for
GRIK5

Expression for GRIK5 Gene

mRNA expression in normal human tissues for GRIK5 Gene

mRNA differential expression in normal tissues according to GTEx for GRIK5 Gene

This gene is overexpressed in Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIK5 Gene

SOURCE GeneReport for Unigene cluster for GRIK5 Gene Hs.367799

genes like me logo Genes that share expressions with GRIK5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for GRIK5 Gene

Orthologs for GRIK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK5 35
  • 99.67 (n)
  • 99.44 (a)
GRIK5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIK5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK5 35
  • 93.71 (n)
  • 99.18 (a)
GRIK5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grik5 35
  • 91.76 (n)
  • 98.26 (a)
Grik5 16
Grik5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIK5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grik5 35
  • 91.66 (n)
  • 98.26 (a)
lizard
(Anolis carolinensis)
Reptilia GRIK5 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik5 35
  • 74.35 (n)
  • 85.59 (a)
zebrafish
(Danio rerio)
Actinopterygii grik5 35
  • 74.77 (n)
  • 84.59 (a)
grik5 36
  • 80 (a)
OneToMany
GRIK5 (2 of 2) 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11155 36
  • 39 (a)
ManyToMany
CG9935 36
  • 36 (a)
ManyToMany
CG4226 37
  • 28 (a)
clumsy 37
  • 35 (a)
CG15627 37
  • 33 (a)
Glu-RIIA 37
  • 30 (a)
CG5621 37
  • 35 (a)
Glu-RIIB 37
  • 27 (a)
CG9935 37
  • 45 (a)
Kai-RIA 37
  • 35 (a)
CG11155 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-4 37
  • 34 (a)
Species with no ortholog for GRIK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK5 Gene

ENSEMBL:
Gene Tree for GRIK5 (if available)
TreeFam:
Gene Tree for GRIK5 (if available)

Paralogs for GRIK5 Gene

Paralogs for GRIK5 Gene

Selected SIMAP similar genes for GRIK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIK5: view

Variants for GRIK5 Gene

Sequence variations from dbSNP and Humsavar for GRIK5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs407096 -- 42,008,129(-) gaggc(A/G)ggaga intron-variant
rs443239 -- 42,001,892(-) tactt(C/G)aatga utr-variant-3-prime, intron-variant
rs454150 -- 42,000,353(-) caggt(C/T)gctct intron-variant
rs729750 -- 42,037,745(+) agcgt(C/T)ccctc intron-variant
rs899661 -- 42,038,314(+) AGGAG(A/C)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK5 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3883n71 CNV Loss 21882294
nsv520239 CNV Loss 19592680
nsv911782 CNV Loss 21882294
esv2677186 CNV Deletion 23128226
esv24829 CNV Loss 19812545

Relevant External Links for GRIK5 Gene

HapMap Linkage Disequilibrium report
GRIK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK5 Gene

Disorders for GRIK5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for GRIK5 Gene including...

Search for GRIK5 Gene in MalaCards »

(1) Novoseek inferred disease relationships for GRIK5 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 41.3 5

Relevant External Links for GRIK5

Genetic Association Database (GAD)
GRIK5
Human Genome Epidemiology (HuGE) Navigator
GRIK5
genes like me logo Genes that share disorders with GRIK5: view

No data available for UniProtKB/Swiss-Prot for GRIK5 Gene

Publications for GRIK5 Gene

  1. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. (PMID: 7527545) Szpirer C. … Copeland N.G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 23
  2. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H. … Fukumaki Y. (Psychiatry Res 2006) 3 23 48
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 48
  4. Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. (PMID: 11279111) Mehta S. … Marshall J. (J. Biol. Chem. 2001) 3 23
  5. Trafficking and surface expression of the glutamate receptor subunit, KA2. (PMID: 14511640) Hayes D.M. … Roche K.W. (Biochem. Biophys. Res. Commun. 2003) 3 23

Products for GRIK5 Gene

Sources for GRIK5 Gene

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