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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

GRIK4 Gene

protein-coding   GIFtS: 63
GCID: GC11P120388

Glutamate Receptor, Ionotropic, Kainate 4


(Previous symbol: GRIK)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Glutamate Receptor, Ionotropic, Kainate 41 2     GluK42 3
GRIK1 2 3     KA12 3
Excitatory Amino Acid Receptor 12 3     Glutamate Receptor Ionotropic, Kainate 42
Glutamate Receptor KA-12 3     Glutamate Receptor KA12
EAA12 3     

External Ids:    HGNC: 45821   Entrez Gene: 29002   Ensembl: ENSG000001494037   OMIM: 6002825   UniProtKB: Q160993   

Export aliases for GRIK4 gene to outside databases

Previous GC identifers: GC11P122530 GC11P122042 GC11P120480 GC11P120068 GC11P120036 GC11P116471 GC11P120386


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for GRIK4 Gene:
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the
major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels
and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric
kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for GRIK4 Gene: 
GRIK4 (glutamate receptor, ionotropic, kainate 4) is a protein-coding gene. Diseases associated with GRIK4 include bipolar disorder, and schizophrenia, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Activation of Kainate Receptors upon glutamate binding. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIK4_HUMAN, Q16099
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
according to their selective agonists

summary for GRIK4 Gene:
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors
contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and
long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an
extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips
into the membrane from the cytoplasmic face to form the pore.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the GRIK4 gene promoter:
         Max1   AML1a   Gfi-1   POU2F1   POU2F1b   POU2F1a   POU2F1c   Hlf   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for GRIK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat GRIK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

GRIK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIK4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P120388:  view genomic region     (about GC identifiers)

Start:
120,382,468 bp from pter      End:
120,859,613 bp from pter
Size:
477,146 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRIK4_HUMAN, Q16099 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, kainate 4 precursor  
Size: 956 amino acids; 107246 Da
Subunit: Forms a heteromeric channel with GRIK1 or GRIK3
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein
Secondary accessions: A8K9L1

Explore the universe of human proteins at neXtProt for GRIK4: NX_Q16099

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16099

  • GRIK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269399.1  NP_001269402.1  NP_055434.2  

    ENSEMBL proteins: 
     ENSP00000435648   ENSP00000404063  
    Reactome Protein details: Q16099
    Human Recombinant Protein Products for GRIK4: 
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    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8263508
    GO:0016020membrane ----
    GO:0030054cell junction IEA--
    GO:0032983kainate selective glutamate receptor complex IEA--

    GRIK4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluK4 
    Ionotropic glutamate receptors

    4 InterPro protein domains:
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry Q16099

    ProtoNet protein and cluster: Q16099

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIK4_HUMAN, Q16099
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily


    GRIK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIK4_HUMAN, Q16099
    Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
    central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
    according to their selective agonists

         Genatlas biochemistry entry for GRIK4:
    glutamate receptor KA1,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IEA--
    GO:0005515protein binding ----
    GO:0015277kainate selective glutamate receptor activity TAS8263508
         
    GRIK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for GRIK4:
     Increased cell number in G2M,  

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Grik4):
     behavior/neurological  homeostasis/metabolism  nervous system  normal 

    GRIK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Grik4tm1.1Sfh for GRIK4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for GRIK4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for GRIK4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Prostacyclin signalling through prostacyclin receptor
    Activation of Kainate Receptors upon glutamate binding0.70
    Activation of Ca-permeable Kainate Receptor0.33
    Ionotropic activity of Kainate Receptors0.33
    3Circadian entrainment
    Glutamatergic synapse0.39
    4Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37
    5Selected targets of ESR1
    Selected targets of ESR1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for GRIK4
        Selected targets of ESR1
    Glutamic acid signaling


    5/6        Reactome Pathways for GRIK4 (see all 6)
        Activation of Kainate Receptors upon glutamate binding
    Transmission across Chemical Synapses
    Activation of Ca-permeable Kainate Receptor
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell


    2         Kegg Pathways  (Kegg details for GRIK4):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse


    GRIK4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for GRIK4

    1 Interacting protein for GRIK4 (Q160993) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIK2Q130023I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8263508
    GO:0007215glutamate receptor signaling pathway TAS8263508
    GO:0007268synaptic transmission TAS--

    GRIK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    GRIK4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for GRIK4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Domoic acid Potent, selective kainate agonist [14277-97-5]
    Kainic acidPotent excitant and neurotoxin[487-79-6]
    CNQXPotent AMPA/kainate antagonist[115066-14-3]
    UBP 302 Selective, potent kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078) [745055-91-8]
    ACETPotent antagonist of GluR5-containing kainate receptors[936095-50-0]

    1 DrugBank Compound for GRIK4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423 8589992

    6 IUPHAR Ligands for GRIK4 (GluK4)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H](2S,4R)-4-methylglutamate
    NoneNone--
    kainate
    AgonistFull agonist--
    domoic acid
    AgonistFull agonist--
    dysiherbaine
    AgonistFull agonist--
    SYM2081
    AgonistFull agonist--
    [3H]kainate
    NoneNone--

    3 Novoseek inferred chemical compound relationships for GRIK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kainate 82.4 18 16325263 (2), 8744443 (2), 18289755 (2), 9099808 (2) (see all 11)
    glutamate 69 17 7527545 (2), 16819533 (2), 18289755 (2), 19526364 (1) (see all 10)
    nmda 55 11 8915893 (2), 20061814 (1), 11334999 (1), 8094892 (1) (see all 6)

    2 PharmGKB related drug/compound annotations for GRIK4 gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  

    Search CenterWatch for drugs/clinical trials and news about GRIK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for GRIK4 gene (3 alternative transcripts): 
    NM_001282470.1  NM_001282473.1  NM_014619.3  

    Unigene Cluster for GRIK4:

    Glutamate receptor, ionotropic, kainate 4
    Hs.568901  [show with all ESTs]
    Unigene Representative Sequence: AK292726
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527524(uc001pxn.2) ENST00000438375(uc009zaw.1 uc009zax.1)
    ENST00000533291(uc009zav.1) ENST00000526536 ENST00000527130 ENST00000530172


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    Additional mRNA sequence: 

    AK292726.1 AK314284.1 BC146652.1 BC150173.1 S67803.1 

    6 DOTS entries:

    DT.91746440  DT.408223  DT.120742671  DT.120742676  DT.91931541  DT.75195214 

    5 AceView cDNA sequences:

    NM_014619 S67803 BX283705 BE388730 BG913572 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    GRIK4 expression in normal human tissues (normalized intensities)      GRIK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGTCAA
    GRIK4 Expression
    About this image


    GRIK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             Mature Ganglion Cells Ganglion Cell Layer

    Genevestigator expression for GRIK4

    SOURCE GeneReport for Unigene cluster: Hs.568901
        SABiosciences Expression via Pathway-Focused PCR Arrays including GRIK4: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GRIK4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grik41 , 5 glutamate receptor, ionotropic, kainate 41, 5 91.77(n)1
    97.91(a)1
      9 (23.80 cM)5
    1106371  NM_175481.51  NP_780690.21 
     425181355 
    chicken
    (Gallus gallus)
    Aves GRIK41 glutamate receptor, ionotropic, kainate 4 85.22(n)
    93.41(a)
      419751  XM_417889.3  XP_417889.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIK46
    glutamate receptor, ionotropic, kainate 4
    92(a)
    1 ↔ 1
    LGa(1706526-2101343)
    zebrafish
    (Danio rerio)
    Actinopterygii grik41 glutamate receptor, ionotropic, kainate 4 75.38(n)
    80.92(a)
      556582  XM_679420.3  XP_684512.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111553 kainate selective glutamate receptor 51(a)
    (best of 8)
        --
    rice
    (Oryza sativa)
    Liliopsida Os07g01031001 hypothetical protein 42.7(n)
    25.52(a)
      4342180  NM_001065222.1  NP_001058687.1 


    ENSEMBL Gene Tree for GRIK4 (if available)
    TreeFam Gene Tree for GRIK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for GRIK4 gene
    GRIA32  GRIN2D2  GRIK12  GRIA22  GRIN12  GRIK22  GRIA12  GRIK32  
    GRIN3A2  GRIN2B2  GRIN2A2  GRIK52  GRIN3B2  GRIA42  GRIN2C2  GRID12  
    GRID22  
    9 SIMAP similar genes for GRIK4 using alignment to 2 protein entries:     GRIK4_HUMAN (see all proteins):
    GRIK5    GRIK2    GRIK1    GRIK3    GRID2    GRIA1
    GRIA2    GRIA3    GRIA4

    GRIK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7083 SNPs in GRIK4 are shown (see all 7083)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0469984
    ----see VAR_0469982 V I mis40--------
    rs1451138011,2
    --120529079(+) TAATCA/GTATAC 1 -- us2k10--------
    rs735804051,2
    C,F--120529116(+) GGAATA/GGAGTT 1 -- us2k16Minor allele frequency- G:0.25WA CSA NA EA 362
    rs766358271,2
    C,F--120529153(+) CTCTAG/CTATAC 1 -- us2k12Minor allele frequency- C:0.03WA NA 238
    rs1389321081,2
    C--120529235(+) CCTTGA/CTAACA 1 -- us2k10--------
    rs1122345041,2
    C,F--120529520(+) TGGCAT/CGATCT 1 -- us2k12Minor allele frequency- C:0.33WA CSA 3
    rs1878954471,2
    --120529545(+) CTCCAA/CCTCCC 1 -- us2k10--------
    rs1504924851,2
    C--120529603(+) TAGGCA/GCCTGC 1 -- us2k10--------
    rs1928596231,2
    --120529822(+) CAGCCA/GCACCC 1 -- us2k10--------
    rs1843949571,2
    C--120529859(+) GCTGTA/CGGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIK4 (120382468 - 120632468 bp, first 250kb of GRIK4)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for GRIK4 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674567CNV Deletion23128226
    esv2745147CNV Deletion23290073
    esv2671584CNV Deletion23128226
    nsv523CNV Insertion18451855
    esv2600363CNV Insertion19546169
    esv28495CNV Loss19812545
    nsv832286CNV Loss17160897
    nsv522869CNV Loss19592680
    nsv523053CNV Loss19592680
    nsv524900CNV Loss19592680


    Human Gene Mutation Database (HGMD): GRIK4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIK4
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600282    OMIM disorders: --

    6 diseases for GRIK4:    About MalaCards
    bipolar disorder    schizophrenia    medulloblastoma    parkinson's disease
    neuroblastoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for GRIK4:
    Schizophrenia

    GRIK4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for GRIK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 43.5 14 18289755 (4), 16325263 (3), 17449450 (2), 16819533 (2) (see all 5)
    bipolar disorder 26.4 3 16819533 (2), 17449450 (1)

    Genetic Association Database (GAD): GRIK4
    Human Genome Epidemiology (HuGE) Navigator: GRIK4 (13 documents)

    Export disorders for GRIK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for GRIK4 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with GRIK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PubMed id 16325263)1, 4, 9 Shibata H....Fukumaki Y. (2006)
    2. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population. (PubMed id 18289755)1, 4, 9 Li Z....Shi Y. (2008)
    3. Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (2010)
    4. Polymorphisms in GRIK4, HTR2A, and FKBP5 show interac tive effects in predicting remission to antidepressant treatment. (PubMed id 19924111)1, 4 Horstmann S....Binder E.B. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    7. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (2009)
    8. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PubMed id 19125103)1, 4 Arai S....Fukumaki Y. (2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    10. A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. (PubMed id 18824690)1, 4 Pickard B.S....Muir W.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2900 HGNC: 4582 AceView: GRIK4 Ensembl:ENSG00000149403 euGenes: HUgn2900
    ECgene: GRIK4 Kegg: 2900 H-InvDB: GRIK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for GRIK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for GRIK4 gene:
    Search GeneIP for patents involving GRIK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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