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Aliases for GRIK4 Gene

Aliases for GRIK4 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 4 2 3
  • Glutamate Receptor, Ionotropic, Kainate 4 2 3 5
  • Excitatory Amino Acid Receptor 1 3 4
  • GluK4 3 4
  • GRIK 3 4
  • EAA1 3 4
  • KA1 3 4
  • Glutamate Receptor KA-1 4
  • Glutamate Receptor KA1 3

External Ids for GRIK4 Gene

Previous HGNC Symbols for GRIK4 Gene

  • GRIK

Previous GeneCards Identifiers for GRIK4 Gene

  • GC11P122530
  • GC11P122042
  • GC11P120068
  • GC11P120036
  • GC11P116471
  • GC11P120386
  • GC11P120388
  • GC11P120391

Summaries for GRIK4 Gene

Entrez Gene Summary for GRIK4 Gene

  • This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for GRIK4 Gene

GRIK4 (Glutamate Ionotropic Receptor Kainate Type Subunit 4) is a Protein Coding gene. Diseases associated with GRIK4 include grik4-related altered drug metabolism and schizophrenia. Among its related pathways are Transmission across Chemical Synapses and Circadian entrainment. GO annotations related to this gene include ionotropic glutamate receptor activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRID1.

UniProtKB/Swiss-Prot for GRIK4 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Tocris Summary for GRIK4 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK4 Gene

Genomics for GRIK4 Gene

Regulatory Elements for GRIK4 Gene

Promoters for GRIK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GRIK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for GRIK4 Gene

Chromosome:
11
Start:
120,511,746 bp from pter
End:
120,988,904 bp from pter
Size:
477,159 bases
Orientation:
Plus strand

Genomic View for GRIK4 Gene

Genes around GRIK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK4 Gene

Proteins for GRIK4 Gene

  • Protein details for GRIK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16099-GRIK4_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 4
    Protein Accession:
    Q16099
    Secondary Accessions:
    • A8K9L1

    Protein attributes for GRIK4 Gene

    Size:
    956 amino acids
    Molecular mass:
    107246 Da
    Quaternary structure:
    • Forms a heteromeric channel with GRIK1 or GRIK3.

neXtProt entry for GRIK4 Gene

Proteomics data for GRIK4 Gene at MOPED

Post-translational modifications for GRIK4 Gene

  • Glycosylation at Asn 158, Asn 220, Asn 272, Asn 286, Asn 323, Asn 408, Asn 415, and Asn 479
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK4 Gene

Antibody Products

No data available for DME Specific Peptides for GRIK4 Gene

Domains & Families for GRIK4 Gene

Gene Families for GRIK4 Gene

Suggested Antigen Peptide Sequences for GRIK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16099

UniProtKB/Swiss-Prot:

GRIK4_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
genes like me logo Genes that share domains with GRIK4: view

Function for GRIK4 Gene

Molecular function for GRIK4 Gene

GENATLAS Biochemistry:
glutamate receptor KA1,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Gene Ontology (GO) - Molecular Function for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005234 extracellular-glutamate-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with GRIK4: view
genes like me logo Genes that share phenotypes with GRIK4: view

Animal Models for GRIK4 Gene

MGI Knock Outs for GRIK4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIK4 Gene

Localization for GRIK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIK4 Gene COMPARTMENTS Subcellular localization image for GRIK4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with GRIK4: view

Pathways & Interactions for GRIK4 Gene

genes like me logo Genes that share pathways with GRIK4: view

Gene Ontology (GO) - Biological Process for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8263508
genes like me logo Genes that share ontologies with GRIK4: view

No data available for SIGNOR curated interactions for GRIK4 Gene

Drugs & Compounds for GRIK4 Gene

(12) Drugs for GRIK4 Gene - From: IUPHAR, DGIdb, Novoseek, Tocris, PharmGKB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 494
Domoic acid Experimental Pharma Full agonist, Agonist Potent, selective kainate agonist 0
kainate Pharma Full agonist, Agonist 0
[<sup>3</sup>H](2S,4R)-4-methylglutamate Pharma 0
[<sup>3</sup>H]kainate Pharma 0

(4) Additional Compounds for GRIK4 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-(-)-5-Iodowillardiine
140187-25-3
Kainic acid
487-79-6
SYM 2081
31137-74-3

(5) Tocris Compounds for GRIK4 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine Highly potent, subtype-selective kainate agonist 140187-25-3
ATPA Selective, potent GluR5 agonist 140158-50-5
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
SYM 2081 Highly selective kainate agonist 31137-74-3
genes like me logo Genes that share compounds with GRIK4: view

Transcripts for GRIK4 Gene

mRNA/cDNA for GRIK4 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK4 Gene

Glutamate receptor, ionotropic, kainate 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK4 Gene

No ASD Table

Relevant External Links for GRIK4 Gene

GeneLoc Exon Structure for
GRIK4
ECgene alternative splicing isoforms for
GRIK4

Expression for GRIK4 Gene

mRNA expression in normal human tissues for GRIK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK4 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Caudate (basal ganglia) (x4.3), and Brain - Hippocampus (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIK4 Gene



SOURCE GeneReport for Unigene cluster for GRIK4 Gene Hs.568901

genes like me logo Genes that share expression patterns with GRIK4: view

Protein tissue co-expression partners for GRIK4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GRIK4 Gene

Orthologs for GRIK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRIK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRIK4 35
  • 93.38 (n)
  • 97.18 (a)
GRIK4 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK4 35
  • 94.91 (n)
  • 99.27 (a)
GRIK4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grik4 35
  • 91.74 (n)
  • 97.91 (a)
Grik4 16
Grik4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GRIK4 35
  • 99.62 (n)
  • 99.9 (a)
GRIK4 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grik4 35
  • 92.12 (n)
  • 97.91 (a)
oppossum
(Monodelphis domestica)
Mammalia GRIK4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRIK4 35
  • 85.18 (n)
  • 93.41 (a)
GRIK4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIK4 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik4 35
  • 76.37 (n)
  • 87.12 (a)
zebrafish
(Danio rerio)
Actinopterygii grik4 35
  • 74.94 (n)
  • 79.81 (a)
grik4 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11155 37
  • 51 (a)
CG15627 37
  • 27 (a)
CG5621 37
  • 36 (a)
CG9935 37
  • 44 (a)
clumsy 37
  • 35 (a)
Glu-RIIA 37
  • 29 (a)
Glu-RIIB 37
  • 27 (a)
Kai-RIA 37
  • 34 (a)
CG11155 36
  • 38 (a)
ManyToMany
CG9935 36
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea glr-4 37
  • 36 (a)
rice
(Oryza sativa)
Liliopsida Os07g0103100 35
  • 43.78 (n)
  • 26.89 (a)
Species with no ortholog for GRIK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK4 Gene

ENSEMBL:
Gene Tree for GRIK4 (if available)
TreeFam:
Gene Tree for GRIK4 (if available)

Paralogs for GRIK4 Gene

Paralogs for GRIK4 Gene

(9) SIMAP similar genes for GRIK4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIK4: view

Variants for GRIK4 Gene

Sequence variations from dbSNP and Humsavar for GRIK4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_046998 -
rs9988907 - 120,982,181(+) GGCTA(C/T)GTTGG reference, missense
rs474867 -- 120,938,005(-) GTAAA(C/T)GTGGC intron-variant
rs477389 -- 120,979,476(-) GAGGA(C/G)CCATC intron-variant
rs478978 -- 120,979,361(-) AACTG(C/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK4 Gene

Variant ID Type Subtype PubMed ID
nsv468881 CNV Gain 19166990
esv27851 CNV Gain 19812545
nsv832286 CNV Loss 17160897
nsv522869 CNV Loss 19592680
nsv524900 CNV Loss 19592680
esv2671584 CNV Deletion 23128226
esv28495 CNV Loss 19812545
esv2745147 CNV Deletion 23290073
esv2600363 CNV Insertion 19546169
nsv523053 CNV Loss 19592680
esv2674567 CNV Deletion 23128226
nsv523 CNV Insertion 18451855

Variation tolerance for GRIK4 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIK4 Gene

HapMap Linkage Disequilibrium report
GRIK4
Human Gene Mutation Database (HGMD)
GRIK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK4 Gene

Disorders for GRIK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRIK4 Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
grik4-related altered drug metabolism
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search GRIK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRIK4

Genetic Association Database (GAD)
GRIK4
Human Genome Epidemiology (HuGE) Navigator
GRIK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIK4
genes like me logo Genes that share disorders with GRIK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK4 Gene

Publications for GRIK4 Gene

  1. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H. … Fukumaki Y. (Psychiatry Res 2006) 3 23 48 67
  2. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population. (PMID: 18289755) Li Z. … Shi Y. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2008) 3 23
  3. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. (PMID: 16819533) Pickard B.S. … Muir W.J. (Mol. Psychiatry 2006) 3 23
  4. Ontogeny of ionotropic glutamate receptor expression in human fetal brain. (PMID: 11334999) Ritter L.M. … Meador-Woodruff J.H. (Brain Res. Dev. Brain Res. 2001) 3 23
  5. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. (PMID: 7527545) Szpirer C. … Copeland N.G. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 23

Products for GRIK4 Gene

Sources for GRIK4 Gene

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