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Aliases for GRIK4 Gene

Aliases for GRIK4 Gene

  • Glutamate Receptor, Ionotropic, Kainate 4 2 3
  • Excitatory Amino Acid Receptor 1 3 4
  • Glutamate Receptor KA-1 3 4
  • GluK4 3 4
  • GRIK 3 4
  • EAA1 3 4
  • KA1 3 4
  • Glutamate Receptor Ionotropic, Kainate 4 3
  • Glutamate Receptor KA1 3

External Ids for GRIK4 Gene

Previous HGNC Symbols for GRIK4 Gene

  • GRIK

Previous GeneCards Identifiers for GRIK4 Gene

  • GC11P122530
  • GC11P122042
  • GC11P120068
  • GC11P120036
  • GC11P116471
  • GC11P120386
  • GC11P120388
  • GC11P120391

Summaries for GRIK4 Gene

Entrez Gene Summary for GRIK4 Gene

  • This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for GRIK4 Gene

GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Transmission across Chemical Synapses. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRID2.

UniProtKB/Swiss-Prot for GRIK4 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists

Tocris Summary for GRIK4 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips into the membrane from the cytoplasmic face to form the pore.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK4 Gene

Genomics for GRIK4 Gene

Regulatory Elements for GRIK4 Gene

Genomic Location for GRIK4 Gene

Start:
120,511,756 bp from pter
End:
120,988,904 bp from pter
Size:
477,149 bases
Orientation:
Plus strand

Genomic View for GRIK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK4 Gene

Proteins for GRIK4 Gene

  • Protein details for GRIK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16099-GRIK4_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 4
    Protein Accession:
    Q16099
    Secondary Accessions:
    • A8K9L1

    Protein attributes for GRIK4 Gene

    Size:
    956 amino acids
    Molecular mass:
    107246 Da
    Quaternary structure:
    • Forms a heteromeric channel with GRIK1 or GRIK3

neXtProt entry for GRIK4 Gene

Proteomics data for GRIK4 Gene at MOPED

Post-translational modifications for GRIK4 Gene

  • Glycosylation at Asn158, Asn220, Asn272, Asn286, Asn323, Asn408, Asn415, and Asn479
  • Modification sites at PhosphoSitePlus

Other Protein References for GRIK4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GRIK4 Gene

Domains for GRIK4 Gene

Gene Families for GRIK4 Gene

HGNC:
  • GR :Glutamate receptors
  • GRI :Ligand-gated ion channels / Glutamate receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for GRIK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16099

UniProtKB/Swiss-Prot:

GRIK4_HUMAN :
  • Q16099
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
genes like me logo Genes that share domains with GRIK4: view

Function for GRIK4 Gene

Molecular function for GRIK4 Gene

GENATLAS Biochemistry: glutamate receptor KA1,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists

Gene Ontology (GO) - Molecular Function for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity --
GO:0005234 extracellular-glutamate-gated ion channel activity IBA --
GO:0005515 protein binding --
GO:0015277 kainate selective glutamate receptor activity IBA --
genes like me logo Genes that share ontologies with GRIK4: view

Phenotypes for GRIK4 Gene

genes like me logo Genes that share phenotypes with GRIK4: view

Animal Models for GRIK4 Gene

MGI Knock Outs for GRIK4:

Animal Model Products

CRISPR Products

miRNA for GRIK4 Gene

miRTarBase miRNAs that target GRIK4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIK4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GRIK4 Gene

Localization for GRIK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GRIK4 Gene COMPARTMENTS Subcellular localization image for GRIK4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8263508
GO:0016020 membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIK4: view

Pathways for GRIK4 Gene

genes like me logo Genes that share pathways with GRIK4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8263508
GO:0007215 glutamate receptor signaling pathway TAS 8263508
GO:0007268 synaptic transmission TAS --
GO:0031960 response to corticosteroid IEA --
GO:0034220 ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with GRIK4: view

Compounds for GRIK4 Gene

(5) Tocris Compounds for GRIK4 Gene

Compound Action Cas Number
ACET Potent antagonist of GluR5-containing kainate receptors [936095-50-0]
ATPA Selective, potent GluR5 agonist [140158-50-5]
CNQX Potent AMPA/kainate antagonist [115066-14-3]
Kainic acid Potent excitant and neurotoxin [487-79-6]
UBP 310 GLUK5 antagonist [902464-46-4]

(1) Drugbank Compounds for GRIK4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(6) IUPHAR Ligand for GRIK4 Gene

Ligand Type Action Affinity Pubmed IDs
SYM2081 Inhibitor Inhibition 5.5
[3H](2S,4R)-4-methylglutamate None None
kainate Agonist Full agonist
domoic acid Agonist Full agonist
dysiherbaine Agonist Full agonist
[3H]kainate None None

(3) Novoseek inferred chemical compound relationships for GRIK4 Gene

Compound -log(P) Hits PubMed IDs
kainate 82.4 15
glutamate 69 13
nmda 55 7

(2) PharmGKB related drug/compound annotations for GRIK4 Gene

Drug/compound Annotation
antidepressants CA
citalopram CA
genes like me logo Genes that share compounds with GRIK4: view

Transcripts for GRIK4 Gene

mRNA/cDNA for GRIK4 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK4 Gene

Glutamate receptor, ionotropic, kainate 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIK4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for GRIK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK4 Gene

No ASD Table

Relevant External Links for GRIK4 Gene

GeneLoc Exon Structure for
GRIK4
ECgene alternative splicing isoforms for
GRIK4

Expression for GRIK4 Gene

mRNA expression in normal human tissues for GRIK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK4 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (5.1), Brain - Anterior cingulate cortex (BA24) (4.6), Brain - Caudate (basal ganglia) (4.3), and Brain - Hippocampus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GRIK4 Gene

SOURCE GeneReport for Unigene cluster for GRIK4 Gene Hs.568901

genes like me logo Genes that share expressions with GRIK4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GRIK4 Gene

Orthologs for GRIK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRIK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK4 35
  • 99.62 (n)
  • 99.9 (a)
GRIK4 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GRIK4 35
  • 93.38 (n)
  • 97.18 (a)
GRIK4 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK4 35
  • 94.91 (n)
  • 99.27 (a)
GRIK4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Grik4 35
  • 91.74 (n)
  • 97.91 (a)
Grik4 16
Grik4 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GRIK4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK4 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Grik4 35
  • 92.12 (n)
  • 97.91 (a)
chicken
(Gallus gallus)
Aves GRIK4 35
  • 85.18 (n)
  • 93.41 (a)
GRIK4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIK4 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik4 35
  • 76.37 (n)
  • 87.12 (a)
zebrafish
(Danio rerio)
Actinopterygii grik4 35
  • 74.94 (n)
  • 79.81 (a)
grik4 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11155 36
  • 38 (a)
ManyToMany
CG9935 36
  • 35 (a)
ManyToMany
clumsy 37
  • 35 (a)
CG15627 37
  • 27 (a)
Glu-RIIA 37
  • 29 (a)
CG5621 37
  • 36 (a)
Glu-RIIB 37
  • 27 (a)
CG9935 37
  • 44 (a)
Kai-RIA 37
  • 34 (a)
CG11155 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-4 37
  • 36 (a)
rice
(Oryza sativa)
Liliopsida Os07g0103100 35
  • 43.78 (n)
  • 26.89 (a)
Species with no ortholog for GRIK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK4 Gene

ENSEMBL:
Gene Tree for GRIK4 (if available)
TreeFam:
Gene Tree for GRIK4 (if available)

Paralogs for GRIK4 Gene

Paralogs for GRIK4 Gene

Selected SIMAP similar genes for GRIK4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIK4: view

Variants for GRIK4 Gene

Sequence variations from dbSNP and Humsavar for GRIK4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471403 -- 120,945,568(+) ATTGG(A/G)CAGTA intron-variant
rs474867 -- 120,938,005(-) GTAAA(C/T)GTGGC intron-variant
rs477389 -- 120,979,476(-) GAGGA(C/G)CCATC intron-variant
rs478978 -- 120,979,361(-) AACTG(C/G)CTGTG intron-variant
rs479160 -- 120,979,295(-) TAATC(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK4 Gene

Variant ID Type Subtype PubMed ID
nsv468881 CNV Gain 19166990
esv27851 CNV Gain 19812545
nsv832286 CNV Loss 17160897
nsv522869 CNV Loss 19592680
nsv524900 CNV Loss 19592680
esv2671584 CNV Deletion 23128226
esv28495 CNV Loss 19812545
esv2745147 CNV Deletion 23290073
esv2600363 CNV Insertion 19546169
nsv523053 CNV Loss 19592680
esv2674567 CNV Deletion 23128226
nsv523 CNV Insertion 18451855

Relevant External Links for GRIK4 Gene

HapMap Linkage Disequilibrium report
GRIK4
Human Gene Mutation Database (HGMD)
GRIK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK4 Gene

Disorders for GRIK4 Gene

(1) University of Copenhagen DISEASES for GRIK4 Gene

(2) Novoseek inferred disease relationships for GRIK4 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 43.5 12
bipolar disorder 26.4 3

Relevant External Links for GRIK4

Genetic Association Database (GAD)
GRIK4
Human Genome Epidemiology (HuGE) Navigator
GRIK4
genes like me logo Genes that share disorders with GRIK4: view

No data available for UniProtKB/Swiss-Prot for GRIK4 Gene

Publications for GRIK4 Gene

  1. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H. … Fukumaki Y. (Psychiatry Res 2006) 3 23 48
  2. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population. (PMID: 18289755) Li Z. … Shi Y. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2008) 3 23 48
  3. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. (PMID: 16819533) Pickard B.S. … Muir W.J. (Mol. Psychiatry 2006) 3 23
  4. Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit. (PMID: 8263508) Kamboj R.K. … Wosnick M.A. (J. Neurochem. 1994) 3 4
  5. A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. (PMID: 18824690) Pickard B.S. … Muir W.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 48

Products for GRIK4 Gene

Sources for GRIK4 Gene

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