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Aliases for GRIK4 Gene

Aliases for GRIK4 Gene

  • Glutamate Ionotropic Receptor Kainate Type Subunit 4 2 3 5
  • Glutamate Receptor, Ionotropic, Kainate 4 2 3
  • Excitatory Amino Acid Receptor 1 3 4
  • GluK4 3 4
  • GRIK 3 4
  • EAA1 3 4
  • KA1 3 4
  • Glutamate Receptor Ionotropic, Kainate 4 3
  • Glutamate Receptor KA-1 4
  • Glutamate Receptor KA1 3

External Ids for GRIK4 Gene

Previous HGNC Symbols for GRIK4 Gene

  • GRIK

Previous GeneCards Identifiers for GRIK4 Gene

  • GC11P122530
  • GC11P122042
  • GC11P120068
  • GC11P120036
  • GC11P116471
  • GC11P120386
  • GC11P120388
  • GC11P120391

Summaries for GRIK4 Gene

Entrez Gene Summary for GRIK4 Gene

  • This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for GRIK4 Gene

GRIK4 (Glutamate Ionotropic Receptor Kainate Type Subunit 4) is a Protein Coding gene. Diseases associated with GRIK4 include Grik4-Related Altered Drug Metabolism and Schizophrenia. Among its related pathways are Presynaptic function of Kainate receptors and Transmission across Chemical Synapses. GO annotations related to this gene include ionotropic glutamate receptor activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIK5.

UniProtKB/Swiss-Prot for GRIK4 Gene

  • Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Tocris Summary for GRIK4 Gene

  • Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. They contribute to excitatory postsynaptic currents in many regions of the CNS.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIK4 Gene

Genomics for GRIK4 Gene

Regulatory Elements for GRIK4 Gene

Enhancers for GRIK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G120906 0.6 ENCODE 48.7 +397.3 397337 4.3 ESRRA NRF1 MAX CEBPG CTBP1 GATA3 FOS MAFK MYC EGR2 GRIK4 TECTA GC11P120895 HMGB1P42
GH11G120563 1.1 Ensembl ENCODE 24.4 +53.6 53568 3.3 HDGF GATA2 EGR1 ZNF143 FOS IKZF2 CREM EGR2 GATAD2B SP1 GRIK4 GC11P120575 GC11P120523
GH11G120540 0.7 ENCODE 23.5 +29.4 29361 1.6 SOX13 TFAP4 MXI1 SAP130 ARID4B CEBPG TEAD3 GATAD2A SOX5 TEAD1 GRIK4 GC11P120523 GC11P120575
GH11G120545 1.2 Ensembl ENCODE 10.6 +35.7 35728 3.4 FOXA2 MLX ARID4B SIN3A ZNF48 GLIS2 FOS SP3 SP5 YY2 GRIK4 GC11P120523 GC11P120575
GH11G120685 0.8 ENCODE 12.2 +173.4 173387 0.2 HDGF CTCF ZNF2 RAD21 ZNF143 SMC3 MAFK ZNF654 MTA2 L3MBTL2 GRIK4 GC11P120649 LOC105369532
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRIK4 on UCSC Golden Path with GeneCards custom track

Promoters for GRIK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045914 0 1001 HDGF RB1 NFXL1 YBX1 ZNF2 ZNF48 RAD21 ZEB1 GLIS2 ZNF143

Genomic Location for GRIK4 Gene

Chromosome:
11
Start:
120,511,700 bp from pter
End:
120,988,904 bp from pter
Size:
477,205 bases
Orientation:
Plus strand

Genomic View for GRIK4 Gene

Genes around GRIK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIK4 Gene

Proteins for GRIK4 Gene

  • Protein details for GRIK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16099-GRIK4_HUMAN
    Recommended name:
    Glutamate receptor ionotropic, kainate 4
    Protein Accession:
    Q16099
    Secondary Accessions:
    • A8K9L1

    Protein attributes for GRIK4 Gene

    Size:
    956 amino acids
    Molecular mass:
    107246 Da
    Quaternary structure:
    • Forms a heteromeric channel with GRIK1 or GRIK3.

neXtProt entry for GRIK4 Gene

Post-translational modifications for GRIK4 Gene

  • Glycosylation at posLast=158158, isoforms=220, posLast=272272, isoforms=286, posLast=323323, posLast=408408, posLast=415415, and posLast=479479
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRIK4 Gene

Domains & Families for GRIK4 Gene

Gene Families for GRIK4 Gene

Suggested Antigen Peptide Sequences for GRIK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16099

UniProtKB/Swiss-Prot:

GRIK4_HUMAN :
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
Family:
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.
genes like me logo Genes that share domains with GRIK4: view

Function for GRIK4 Gene

Molecular function for GRIK4 Gene

GENATLAS Biochemistry:
glutamate receptor KA1,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
UniProtKB/Swiss-Prot Function:
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Gene Ontology (GO) - Molecular Function for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004970 ionotropic glutamate receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005234 extracellular-glutamate-gated ion channel activity IEA --
GO:0015276 ligand-gated ion channel activity TAS --
GO:0015277 kainate selective glutamate receptor activity TAS 8263508
genes like me logo Genes that share ontologies with GRIK4: view
genes like me logo Genes that share phenotypes with GRIK4: view

Animal Models for GRIK4 Gene

MGI Knock Outs for GRIK4:

Animal Model Products

  • Taconic Biosciences Mouse Models for GRIK4

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRIK4 Gene

Localization for GRIK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIK4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIK4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8263508
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIK4: view

Pathways & Interactions for GRIK4 Gene

genes like me logo Genes that share pathways with GRIK4: view

Gene Ontology (GO) - Biological Process for GRIK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8263508
GO:0006811 ion transport IEA --
GO:0007215 glutamate receptor signaling pathway TAS 8263508
GO:0007268 chemical synaptic transmission TAS 8263508
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GRIK4: view

No data available for SIGNOR curated interactions for GRIK4 Gene

Drugs & Compounds for GRIK4 Gene

(23) Drugs for GRIK4 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Topiramate Approved Pharma GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 249
Domoic acid Experimental Pharma Full agonist, Agonist Potent, selective kainate agonist 0
kainate Pharma Full agonist, Agonist 0
ACET Pharma Antagonist Potent antagonist of GluR5-containing kainate receptors 0
Kainic acid Pharma kainate receptor agonist, selective, Potent excitant and neurotoxin 0

(1) Additional Compounds for GRIK4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GRIK4 Gene

Compound Action Cas Number
ACET Potent antagonist of GluR5-containing kainate receptors 936095-50-0
CNQX Potent AMPA/kainate antagonist 115066-14-3
Domoic acid Potent, selective kainate agonist 14277-97-5
Kainic acid Potent excitant and neurotoxin 487-79-6
Topiramate GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 97240-79-4

(12) ApexBio Compounds for GRIK4 Gene

Compound Action Cas Number
(S)-(-)-5-Iodowillardiine 140187-25-3
ACET 936095-50-0
ATPA 140158-50-5
Domoic acid 14277-97-5
Kainic acid kainate receptor agonist, selective 487-79-6
NS 3763 70553-45-6
PDZ1 Domain inhibitor peptide 1315378-73-4
SYM 2081 31137-74-3
UBP 296 745055-86-1
UBP 301 569371-10-4
UBP 302 745055-91-8
UBP 310 902464-46-4
genes like me logo Genes that share compounds with GRIK4: view

Drug Products

Transcripts for GRIK4 Gene

mRNA/cDNA for GRIK4 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIK4 Gene

Glutamate receptor, ionotropic, kainate 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIK4 Gene

No ASD Table

Relevant External Links for GRIK4 Gene

GeneLoc Exon Structure for
GRIK4
ECgene alternative splicing isoforms for
GRIK4

Expression for GRIK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRIK4 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Caudate (basal ganglia) (x4.3), and Brain - Hippocampus (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GRIK4 Gene



Protein tissue co-expression partners for GRIK4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIK4 Gene:

GRIK4

SOURCE GeneReport for Unigene cluster for GRIK4 Gene:

Hs.568901

Evidence on tissue expression from TISSUES for GRIK4 Gene

  • Nervous system(4.5)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with GRIK4: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIK4 Gene

Orthologs for GRIK4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GRIK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GRIK4 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIK4 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GRIK4 34 35
  • 94.91 (n)
cow
(Bos Taurus)
Mammalia GRIK4 34 35
  • 93.38 (n)
rat
(Rattus norvegicus)
Mammalia Grik4 34
  • 92.12 (n)
mouse
(Mus musculus)
Mammalia Grik4 34 16 35
  • 91.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GRIK4 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GRIK4 34 35
  • 85.18 (n)
lizard
(Anolis carolinensis)
Reptilia GRIK4 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia grik4 34
  • 76.37 (n)
zebrafish
(Danio rerio)
Actinopterygii grik4 34 35
  • 74.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11155 36 35
  • 51 (a)
CG9935 36 35
  • 44 (a)
CG5621 36
  • 36 (a)
clumsy 36
  • 35 (a)
Kai-RIA 36
  • 34 (a)
Glu-RIIA 36
  • 29 (a)
CG15627 36
  • 27 (a)
Glu-RIIB 36
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea glr-4 36
  • 36 (a)
rice
(Oryza sativa)
Liliopsida Os07g0103100 34
  • 43.78 (n)
Species where no ortholog for GRIK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRIK4 Gene

ENSEMBL:
Gene Tree for GRIK4 (if available)
TreeFam:
Gene Tree for GRIK4 (if available)

Paralogs for GRIK4 Gene

Paralogs for GRIK4 Gene

(9) SIMAP similar genes for GRIK4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GRIK4: view

Variants for GRIK4 Gene

Sequence variations from dbSNP and Humsavar for GRIK4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1954787 drug-response 120,792,654(+) GTTAT(C/T)GGAAG intron-variant
rs534517447 Likely pathogenic 120,956,935(+) CACCC(A/G)CTGTG intron-variant, reference, missense
rs869312699 Likely pathogenic 120,986,102(+) AGAGA(CTGGCGCAGGAGGCC/GCT)GCCCT cds-indel
rs1000000898 -- 120,558,481(+) TACTC(A/G)GGAGG intron-variant
rs1000003003 -- 120,757,761(+) AGGAG(A/G)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIK4 Gene

Variant ID Type Subtype PubMed ID
dgv1289n100 CNV gain 25217958
dgv1290n100 CNV gain 25217958
esv22400 CNV loss 19812545
esv2600363 CNV insertion 19546169
esv2662643 CNV deletion 23128226
esv2666173 CNV deletion 23128226
esv2671584 CNV deletion 23128226
esv2674567 CNV deletion 23128226
esv2745146 CNV deletion 23290073
esv2745147 CNV deletion 23290073
esv27851 CNV gain 19812545
esv28495 CNV loss 19812545
esv3332666 CNV duplication 20981092
esv3365919 CNV insertion 20981092
esv3417008 CNV duplication 20981092
esv3428981 CNV insertion 20981092
esv3548428 CNV deletion 23714750
esv3627905 CNV loss 21293372
esv3627906 CNV loss 21293372
esv3627907 CNV gain 21293372
esv3627908 CNV loss 21293372
esv3627909 CNV loss 21293372
esv3627910 CNV loss 21293372
esv3627911 CNV loss 21293372
nsv1036388 CNV gain 25217958
nsv1053607 CNV gain 25217958
nsv1053749 CNV gain 25217958
nsv1118223 CNV deletion 24896259
nsv1150134 CNV deletion 26484159
nsv468881 CNV gain 19166990
nsv474304 CNV novel sequence insertion 20440878
nsv477241 CNV novel sequence insertion 20440878
nsv478755 CNV novel sequence insertion 20440878
nsv522869 CNV loss 19592680
nsv523 CNV insertion 18451855
nsv523053 CNV loss 19592680
nsv524900 CNV loss 19592680
nsv556472 CNV loss 21841781
nsv556473 CNV loss 21841781
nsv556474 CNV loss 21841781
nsv556475 CNV loss 21841781
nsv556476 CNV gain 21841781
nsv826105 CNV gain 20364138
nsv826106 CNV loss 20364138
nsv832286 CNV loss 17160897
nsv975985 CNV duplication 23825009

Variation tolerance for GRIK4 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIK4 Gene

Human Gene Mutation Database (HGMD)
GRIK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIK4 Gene

Disorders for GRIK4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRIK4 Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
grik4-related altered drug metabolism
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search GRIK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GRIK4

Genetic Association Database (GAD)
GRIK4
Human Genome Epidemiology (HuGE) Navigator
GRIK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIK4
genes like me logo Genes that share disorders with GRIK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRIK4 Gene

Publications for GRIK4 Gene

  1. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population. (PMID: 18289755) Li Z. … Shi Y. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2008) 3 22 46 64
  2. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PMID: 16325263) Shibata H. … Fukumaki Y. (Psychiatry Res 2006) 3 22 46 64
  3. Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment. (PMID: 19924111) Horstmann S. … Binder E.B. (Neuropsychopharmacology 2010) 3 46 64
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for GRIK4 Gene

Sources for GRIK4 Gene

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