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GRIK4 Gene

protein-coding   GIFtS: 65
GCID: GC11P120391

Glutamate Receptor, Ionotropic, Kainate 4


(Previous symbol: GRIK)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamate Receptor, Ionotropic, Kainate 41 2     GluK42 3
GRIK1 2 3     KA12 3
Excitatory Amino Acid Receptor 12 3     Glutamate Receptor Ionotropic, Kainate 42
Glutamate Receptor KA-12 3     Glutamate Receptor KA12
EAA12 3     

External Ids:    HGNC: 45821   Entrez Gene: 29002   Ensembl: ENSG000001494037   OMIM: 6002825   UniProtKB: Q160993   

Export aliases for GRIK4 gene to outside databases

Previous GC identifers: GC11P122530 GC11P122042 GC11P120480 GC11P120068 GC11P120036 GC11P116471 GC11P120386 GC11P120388


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for GRIK4 Gene:
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the
major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels
and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric
kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2013)

GeneCards Summary for GRIK4 Gene:
GRIK4 (glutamate receptor, ionotropic, kainate 4) is a protein-coding gene. GO annotations related to this gene include extracellular-glutamate-gated ion channel activity and kainate selective glutamate receptor activity. An important paralog of this gene is GRIA3.

UniProtKB/Swiss-Prot: GRIK4_HUMAN, Q16099
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
according to their selective agonists

summary for GRIK4 Gene:
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and
AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors
contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and
long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an
extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips
into the membrane from the cytoplasmic face to form the pore.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the GRIK4 gene promoter:
         Max1   AML1a   Gfi-1   POU2F1   POU2F1b   POU2F1a   POU2F1c   Hlf   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGRIK4 promoter sequence
   Search Chromatin IP Primers for GRIK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GRIK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

GRIK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GRIK4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P120391:  view genomic region     (about GC identifiers)

Start:
120,382,468 bp from pter      End:
120,859,613 bp from pter
Size:
477,146 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GRIK4_HUMAN, Q16099 (See protein sequence)
Recommended Name: Glutamate receptor ionotropic, kainate 4 precursor  
Size: 956 amino acids; 107246 Da
Subunit: Forms a heteromeric channel with GRIK1 or GRIK3
Secondary accessions: A8K9L1

Explore the universe of human proteins at neXtProt for GRIK4: NX_Q16099

Explore proteomics data for GRIK4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn158, Asn220, Asn272, Asn286, Asn323, Asn408, Asn415, Asn479
  • Modification sites at PhosphoSitePlus

  • See GRIK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269399.1  NP_001269402.1  NP_055434.2  

    ENSEMBL proteins: 
     ENSP00000435648   ENSP00000404063  
    Reactome Protein details: Q16099

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GRI: Ligand-gated ion channels / Glutamate receptors, ionotropic
    GR: Glutamate receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: GluK4
    Ionotropic glutamate receptors

    5 InterPro protein domains:
     IPR028082 Peripla_BP_I
     IPR019594 Glu_rcpt_Glu/Gly-bd
     IPR001320 Iontro_glu_rcpt
     IPR001828 ANF_lig-bd_rcpt
     IPR001508 NMDA_rcpt

    Graphical View of Domain Structure for InterPro Entry Q16099

    ProtoNet protein and cluster: Q16099

    3 Blocks protein domains:
    IPB001320 Ionotropic glutamate receptor
    IPB001508 NMDA receptor signature
    IPB001828 Extracellular ligand-binding receptor


    UniProtKB/Swiss-Prot: GRIK4_HUMAN, Q16099
    Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily


    Find genes that share domains with GRIK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRIK4_HUMAN, Q16099
    Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the
    central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named
    according to their selective agonists

         Genatlas biochemistry entry for GRIK4:
    glutamate receptor KA1,ionotropic,kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004970ionotropic glutamate receptor activity ----
    GO:0005215transporter activity ----
    GO:0005234extracellular-glutamate-gated ion channel activity IBA--
    GO:0005515protein binding ----
    GO:0015277kainate selective glutamate receptor activity IBA--
         
    Find genes that share ontologies with GRIK4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GRIK4:
     Increased cell number in G2M,  

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Grik4):
     behavior/neurological  homeostasis/metabolism  nervous system  normal 

    Find genes that share phenotypes with GRIK4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Grik4tm1.1Sfh for GRIK4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for GRIK4
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    miRTarBase miRNAs that target GRIK4:
    hsa-mir-335-5p (MIRT017088), hsa-mir-196a-5p (MIRT048273)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRIK4_HUMAN, Q16099: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8263508
    GO:0016020membrane ----
    GO:0030054cell junction IEA--

    Find genes that share ontologies with GRIK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GRIK4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2ADP signalling through P2Y purinoceptor 12
    Activation of Kainate Receptors upon glutamate binding0.68
    Ionotropic activity of Kainate Receptors0.00
    Activation of Ca-permeable Kainate Receptor0.35
    3Circadian entrainment
    Glutamatergic synapse0.39
    4Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    5Selected targets of ESR1
    Selected targets of ESR1


    Find genes that share SuperPaths with GRIK4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for GRIK4
        Activation of Ca-permeable Kainate Receptor


    2 Kegg Pathways  (Kegg details for GRIK4):
        Neuroactive ligand-receptor interaction
    Glutamatergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIK4: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for GRIK4

    1 Interacting protein for GRIK4 (Q160993) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIK2Q130023I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8263508
    GO:0007215glutamate receptor signaling pathway TAS8263508
    GO:0007268synaptic transmission TAS--
    GO:0031960response to corticosteroid IEA--
    GO:0034220ion transmembrane transport IBA--

    Find genes that share ontologies with GRIK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for GRIK4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Domoic acid Potent, selective kainate agonist [14277-97-5]
    Kainic acidPotent excitant and neurotoxin[487-79-6]
    CNQXPotent AMPA/kainate antagonist[115066-14-3]
    UBP 302 Selective, potent kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078) [745055-91-8]
    ACETPotent antagonist of GluR5-containing kainate receptors[936095-50-0]

    1 DrugBank Compound for GRIK4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423 8589992

    6 IUPHAR Ligands for GRIK4 (GluK4)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H](2S,4R)-4-methylglutamate
    NoneNone--
    kainate
    AgonistFull agonist--
    domoic acid
    AgonistFull agonist--
    dysiherbaine
    AgonistFull agonist--
    SYM2081
    AgonistFull agonist--
    [3H]kainate
    NoneNone--

    3 Novoseek inferred chemical compound relationships for GRIK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kainate 82.4 18 16325263 (2), 8744443 (2), 18289755 (2), 9099808 (2) (see all 11)
    glutamate 69 17 7527545 (2), 16819533 (2), 18289755 (2), 19526364 (1) (see all 10)
    nmda 55 11 8915893 (2), 20061814 (1), 11334999 (1), 8094892 (1) (see all 6)

    2 PharmGKB related drug/compound annotations for GRIK4 gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  



    Find genes that share compounds with GRIK4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GRIK4 gene (3 alternative transcripts): 
    NM_001282470.1  NM_001282473.1  NM_014619.3  

    Unigene Cluster for GRIK4:

    Glutamate receptor, ionotropic, kainate 4
    Hs.568901  [show with all ESTs]
    Unigene Representative Sequence: AK292726
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527524(uc001pxn.2) ENST00000438375(uc009zaw.1 uc009zax.1)
    ENST00000533291(uc009zav.1) ENST00000526536 ENST00000527130 ENST00000530172

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    Additional mRNA sequence: 

    AK292726.1 AK314284.1 BC146652.1 BC150173.1 S67803.1 

    6 DOTS entries:

    DT.91746440  DT.408223  DT.120742671  DT.120742676  DT.91931541  DT.75195214 

    5 AceView cDNA sequences:

    NM_014619 BX283705 S67803 BE388730 BG913572 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GRIK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATGTCAA
    GRIK4 Expression
    About this image


    GRIK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Mature Ganglion Cells Ganglion Cell Layer
     
     Eye (Sensory Organs)
             Mature Ganglion Cells Ganglion Cell Layer
    GRIK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GRIK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.568901
        Pathway & Disease-focused RT2 Profiler PCR Arrays including GRIK4: 
              Neurotransmitter Receptors in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GRIK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for GRIK4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Grik41 , 5 glutamate receptor, ionotropic, kainate 41, 5 91.74(n)1
    97.91(a)1
      9 (23.80 cM)5
    1106371  NM_175481.51  NP_780690.21 
     425181355 
    chicken
    (Gallus gallus)
    Aves GRIK41 glutamate receptor, ionotropic, kainate 4 85.18(n)
    93.41(a)
      419751  XM_417889.4  XP_417889.2 
    lizard
    (Anolis carolinensis)
    Reptilia GRIK46
    glutamate receptor, ionotropic, kainate 4
    92(a)
    1 ↔ 1
    LGa(1706526-2101343)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia grik41 glutamate receptor, ionotropic, kainate 4 76.37(n)
    87.12(a)
      100490768  XM_004916121.1  XP_004916178.1 
    zebrafish
    (Danio rerio)
    Actinopterygii grik41 glutamate receptor, ionotropic, kainate 4 74.94(n)
    79.81(a)
      556582  XM_679420.4  XP_684512.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111553 kainate selective glutamate receptor 51(a)
    (best of 8)
        --
    rice
    (Oryza sativa)
    Liliopsida Os07g01031001 Os07g0103100 43.78(n)
    26.89(a)
      4342180  NM_001065222.1  NP_001058687.1 


    ENSEMBL Gene Tree for GRIK4 (if available)
    TreeFam Gene Tree for GRIK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GRIK4 gene
    GRIA32  GRIK52  GRIK12  GRIA22  GRIA42  GRIK22  GRID12  GRIA12  
    GRIK32  GRID22  
    9 SIMAP similar genes for GRIK4 using alignment to 2 protein entries:     GRIK4_HUMAN (see all proteins):
    GRIK5    GRIK2    GRIK1    GRIK3    GRID2    GRIA1
    GRIA2    GRIA3    GRIA4

    Find genes that share paralogs with GRIK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for GRIK4 (see all 7083)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451138011,2
    --120529079(+) TAATCA/GTATAC 1 -- us2k10--------
    rs735804051,2
    C,F--120529116(+) GGAATA/GGAGTT 1 -- us2k16Minor allele frequency- G:0.25WA CSA NA EA 362
    rs766358271,2
    C,F--120529153(+) CTCTAG/CTATAC 1 -- us2k12Minor allele frequency- C:0.03WA NA 238
    rs1389321081,2
    C--120529235(+) CCTTGA/CTAACA 1 -- us2k10--------
    rs1122345041,2
    C,F--120529520(+) TGGCAT/CGATCT 1 -- us2k12Minor allele frequency- C:0.33WA CSA 3
    rs1878954471,2
    --120529545(+) CTCCAA/CCTCCC 1 -- us2k10--------
    rs1504924851,2
    C--120529603(+) TAGGCA/GCCTGC 1 -- us2k10--------
    rs1928596231,2
    --120529822(+) CAGCCA/GCACCC 1 -- us2k10--------
    rs1843949571,2
    C--120529859(+) GCTGTA/CGGCAG 1 -- us2k10--------
    rs1383235071,2
    --120529894(+) GGCACA/GTGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for GRIK4 (120382468 - 120632468 bp, first 250kb of GRIK4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GRIK4 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674567CNV Deletion23128226
    esv2745147CNV Deletion23290073
    esv2671584CNV Deletion23128226
    nsv523CNV Insertion18451855
    esv2600363CNV Insertion19546169
    esv28495CNV Loss19812545
    nsv832286CNV Loss17160897
    nsv522869CNV Loss19592680
    nsv523053CNV Loss19592680
    nsv524900CNV Loss19592680

    Human Gene Mutation Database (HGMD): GRIK4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing GRIK4
    DNA2.0 Custom Variant and Variant Library Synthesis for GRIK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600282    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for GRIK4:
    Schizophrenia

    Find genes that share disorders with GRIK4           About GenesLikeMe

    2 Novoseek inferred disease relationships for GRIK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 43.5 14 18289755 (4), 16325263 (3), 17449450 (2), 16819533 (2) (see all 5)
    bipolar disorder 26.4 3 16819533 (2), 17449450 (1)

    Genetic Association Database (GAD): GRIK4
    Human Genome Epidemiology (HuGE) Navigator: GRIK4 (13 documents)

    Export disorders for GRIK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GRIK4 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with GRIK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. (PubMed id 16325263)1, 4, 9 Shibata H....Fukumaki Y. (Psychiatry Res 2006)
    2. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population. (PubMed id 18289755)1, 4, 9 Li Z....Shi Y. (amp 2008)
    3. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    4. Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment. (PubMed id 19924111)1, 4 Horstmann S....Binder E.B. (Neuropsychopharmacology 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    7. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    9. Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia. (PubMed id 19125103)1, 4 Arai S....Fukumaki Y. (Psychiatr. Genet. 2009)
    10. A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. (PubMed id 18824690)1, 4 Pickard B.S....Muir W.J. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2900 HGNC: 4582 AceView: GRIK4 Ensembl:ENSG00000149403 euGenes: HUgn2900
    ECgene: GRIK4 Kegg: 2900 H-InvDB: GRIK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GRIK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GRIK4 gene:
    Search GeneIP for patents involving GRIK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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